AR073909A1 - Anticuerpo aislado que se enlaza al dominio extracelular del receptor ii de tgfb humano (tgfbrii), fragmento de enlace a tgfbrii humano y composicion farmaceutica que lo comprende. - Google Patents
Anticuerpo aislado que se enlaza al dominio extracelular del receptor ii de tgfb humano (tgfbrii), fragmento de enlace a tgfbrii humano y composicion farmaceutica que lo comprende.Info
- Publication number
- AR073909A1 AR073909A1 ARP090104017A ARP090104017A AR073909A1 AR 073909 A1 AR073909 A1 AR 073909A1 AR P090104017 A ARP090104017 A AR P090104017A AR P090104017 A ARP090104017 A AR P090104017A AR 073909 A1 AR073909 A1 AR 073909A1
- Authority
- AR
- Argentina
- Prior art keywords
- human
- tgfbrii
- extracellular domain
- understands
- fragment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anticuerpos contra el receptor II del factor beta del crecimiento de transformacion humano (TGFbetaRII). Los anticuerpos se enlazan al dominio extracelular del receptor II de TGFbeta humano (TGFbetaRII) con un KD de menos de 100 pM a temperatura ambiente (20-25°C). Composiciones farmacéuticas que comprenden estos anticuerpos y métodos para usar los anticuerpos, solos o en combinacion, por ejemplo para tratar cáncer y fibrosis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19869708P | 2008-11-07 | 2008-11-07 | |
US17036909P | 2009-04-17 | 2009-04-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR073909A1 true AR073909A1 (es) | 2010-12-09 |
Family
ID=41508691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090104017A AR073909A1 (es) | 2008-11-07 | 2009-10-19 | Anticuerpo aislado que se enlaza al dominio extracelular del receptor ii de tgfb humano (tgfbrii), fragmento de enlace a tgfbrii humano y composicion farmaceutica que lo comprende. |
Country Status (19)
Country | Link |
---|---|
US (2) | US8147834B2 (es) |
EP (1) | EP2356152A1 (es) |
JP (1) | JP5667067B2 (es) |
KR (1) | KR101283856B1 (es) |
CN (1) | CN102209727B (es) |
AR (1) | AR073909A1 (es) |
AU (1) | AU2009311375B2 (es) |
BR (1) | BRPI0921263A2 (es) |
CA (1) | CA2742961C (es) |
EA (1) | EA025169B1 (es) |
IL (1) | IL211842A (es) |
JO (1) | JO3096B1 (es) |
MX (1) | MX2011004871A (es) |
NZ (1) | NZ591943A (es) |
PA (1) | PA8846101A1 (es) |
SG (1) | SG10201401280TA (es) |
TW (1) | TWI384998B (es) |
WO (1) | WO2010053814A1 (es) |
ZA (1) | ZA201103178B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2661449B1 (en) | 2011-01-06 | 2017-03-22 | Glaxo Group Limited | Ligands that bind tgf-beta receptor ii |
AR086044A1 (es) | 2011-05-12 | 2013-11-13 | Imclone Llc | Anticuerpos que se unen especificamente a un dominio extracelular de c-kit y usos de los mismos |
US10828353B2 (en) | 2015-01-31 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
BR112018008867A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | anticorpos que se ligam especificamente a pd-1 e seus usos |
DK3365368T3 (da) | 2016-03-11 | 2023-06-26 | Scholar Rock Inc | Tgfbeta1-bindende immunoglobuliner og anvendelse deraf |
AR109770A1 (es) * | 2016-10-18 | 2019-01-23 | Lilly Co Eli | ANTICUERPOS DEL RECEPTOR II DE TGF-b |
CN106884005A (zh) * | 2017-01-19 | 2017-06-23 | 樊克兴 | 一种结直肠癌抗原特异性t细胞的制备方法 |
CN111601616A (zh) | 2017-10-24 | 2020-08-28 | 美真达治疗公司 | 用于耗尽cd117+细胞的组合物和方法 |
WO2019084053A1 (en) * | 2017-10-24 | 2019-05-02 | Magenta Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS |
US10899843B2 (en) | 2017-10-24 | 2021-01-26 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD117+ cells |
CN107973853B (zh) * | 2017-12-12 | 2021-04-30 | 山西农业大学 | 一种利用特征多肽制备Smad2蛋白特异性抗体的方法及其应用 |
JP2023508202A (ja) * | 2019-12-24 | 2023-03-01 | メルス ナムローゼ フェンノートシャップ | TGF-βRII結合タンパク質 |
KR102314157B1 (ko) * | 2020-01-10 | 2021-10-19 | 주식회사 뉴클릭스바이오 | TGF-β 수용체에 특이적으로 결합하는 항체 및 이의 이용방법 |
WO2023198194A1 (en) * | 2022-04-15 | 2023-10-19 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Anti-cd40 antibodies and uses thereof |
CN116178567A (zh) * | 2022-10-28 | 2023-05-30 | 四川大学华西医院 | 一种靶向TGFβRII的嵌合抗原受体及其用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2136092T3 (es) * | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
DE69232986T2 (de) * | 1991-10-31 | 2003-12-11 | Whitehead Institute For Biomedical Research, Cambridge | TGF-BETA TYP III REZEPTOR, DAFüR KODIERENDE CDNS UND DEREN VERWENDUNG |
JP2001206899A (ja) * | 1999-11-18 | 2001-07-31 | Japan Tobacco Inc | TGF−βII型受容体に対するヒトモノクローナル抗体及びその医薬用途 |
JP2004121001A (ja) * | 2002-08-07 | 2004-04-22 | Japan Tobacco Inc | TGF−βII型受容体に対する高親和性モノクローナル抗体 |
WO2007088651A1 (ja) * | 2006-02-01 | 2007-08-09 | The University Of Tokyo | TGF-βシグナル阻害剤と抗腫瘍剤の組み合せ使用 |
-
2009
- 2009-10-18 JO JOP/2009/0382A patent/JO3096B1/ar active
- 2009-10-19 AR ARP090104017A patent/AR073909A1/es unknown
- 2009-10-19 PA PA20098846101A patent/PA8846101A1/es unknown
- 2009-10-19 TW TW098135300A patent/TWI384998B/zh not_active IP Right Cessation
- 2009-10-29 SG SG10201401280TA patent/SG10201401280TA/en unknown
- 2009-10-29 NZ NZ591943A patent/NZ591943A/xx not_active IP Right Cessation
- 2009-10-29 JP JP2011534731A patent/JP5667067B2/ja not_active Expired - Fee Related
- 2009-10-29 AU AU2009311375A patent/AU2009311375B2/en not_active Ceased
- 2009-10-29 US US12/608,034 patent/US8147834B2/en not_active Expired - Fee Related
- 2009-10-29 KR KR1020117010399A patent/KR101283856B1/ko not_active IP Right Cessation
- 2009-10-29 EA EA201170659A patent/EA025169B1/ru not_active IP Right Cessation
- 2009-10-29 CN CN200980144391.1A patent/CN102209727B/zh not_active Expired - Fee Related
- 2009-10-29 BR BRPI0921263-9A patent/BRPI0921263A2/pt not_active IP Right Cessation
- 2009-10-29 WO PCT/US2009/062450 patent/WO2010053814A1/en active Application Filing
- 2009-10-29 MX MX2011004871A patent/MX2011004871A/es active IP Right Grant
- 2009-10-29 CA CA2742961A patent/CA2742961C/en not_active Expired - Fee Related
- 2009-10-29 EP EP09745224A patent/EP2356152A1/en not_active Withdrawn
-
2011
- 2011-03-21 IL IL211842A patent/IL211842A/en not_active IP Right Cessation
- 2011-04-29 ZA ZA2011/03178A patent/ZA201103178B/en unknown
-
2012
- 2012-02-20 US US13/400,308 patent/US20120177666A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ591943A (en) | 2012-11-30 |
PA8846101A1 (es) | 2010-06-28 |
EA201170659A1 (ru) | 2011-10-31 |
TW201026326A (en) | 2010-07-16 |
KR20110067155A (ko) | 2011-06-21 |
ZA201103178B (en) | 2012-10-31 |
WO2010053814A1 (en) | 2010-05-14 |
CA2742961A1 (en) | 2010-05-14 |
MX2011004871A (es) | 2011-07-13 |
EP2356152A1 (en) | 2011-08-17 |
AU2009311375A1 (en) | 2010-05-14 |
SG10201401280TA (en) | 2014-05-29 |
EA025169B1 (ru) | 2016-11-30 |
US8147834B2 (en) | 2012-04-03 |
JP5667067B2 (ja) | 2015-02-12 |
BRPI0921263A2 (pt) | 2015-08-04 |
CA2742961C (en) | 2016-08-30 |
AU2009311375B2 (en) | 2014-07-31 |
CN102209727A (zh) | 2011-10-05 |
US20100119516A1 (en) | 2010-05-13 |
CN102209727B (zh) | 2014-07-30 |
JO3096B1 (ar) | 2017-03-15 |
US20120177666A1 (en) | 2012-07-12 |
KR101283856B1 (ko) | 2013-07-15 |
IL211842A (en) | 2016-09-29 |
IL211842A0 (en) | 2011-06-30 |
TWI384998B (zh) | 2013-02-11 |
JP2012508170A (ja) | 2012-04-05 |
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