TWI322011B - New use of iloperidone - Google Patents
New use of iloperidone Download PDFInfo
- Publication number
- TWI322011B TWI322011B TW091101815A TW91101815A TWI322011B TW I322011 B TWI322011 B TW I322011B TW 091101815 A TW091101815 A TW 091101815A TW 91101815 A TW91101815 A TW 91101815A TW I322011 B TWI322011 B TW I322011B
- Authority
- TW
- Taiwan
- Prior art keywords
- base
- pharmaceutically acceptable
- propoxy
- acid addition
- addition salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
U22011 A7 ------ B7 ^_ 五、發明説明（3 ) 性失調（如泛化焦慮症、社交恐懼症及廣場恐懼症），以及 特徵為社交退缩之行為狀態（如孤獨症及具有顯著負面症 狀[青春期癡呆]之精神病）。 對於上述適應症而言，適當之劑量將依如所應用之化合 物、宿主、投藥方式及治療疾病之種類與嚴重性而異。然 而’一般來說每曰約1至約5〇毫克/公斤動物體重之劑量可 在動物身上獲得滿意的結果。較大動物之每日劑量（如人 類）係依據各種行為性失調的g床研究結果而異且為由約1 至約50毫克之本發明藥劑，該劑量可方便地分為一天達兩 次的投藥劑量。 本發明藥劑可以任何慣用方法投藥，如以片劑或膠囊型 式口服，或以注射溶液或懸浮液腸道外投藥。 本發明亦提供包括本發明藥劑與至少一種醫藥學載劑或 稀釋劑之醫藥學組合物，其可用於治療情感性及注意力失 調。該组合物可以慣用方法製備。單位劑型中可含如由約 〇. 1毫克至約25毫克之式I化合物。 本發明進一步^供以本發明藥劑製備可治療情感性及注 意力/行為性失調之醫藥學年合物的用法。 本發明更進一步提供一種情感性及注意力之治療方法給予 需要該治療之對象’其包括對該對象投予治療有效量之本 發明藥劑。 -6- 本纸張尺度適用中國S家揉箏(CNS) A4規格(210 X 297公嫠)
Claims (1)
- A8 B8 1322U11 第091101815號專利申請案 中文申請專利範圍替換本(98年π月f ——1 _-- 申請專利範園 1. 一種用於治療兩極性失調症之藥物，其包含 1-[4-[3-[4-(6-氟-1，2-苯異11号17坐基_3基）小味咬基]丙氧 基]-3-甲氧基笨基]乙醯酮或其醫藥學可接受之酸加成鹽 作為活性成份。 2· —種用於治療兩極性失調症之醫藥組合物，其包含 1-[4-[3-[4-(6-氟-1，2·苯異，号D坐_3基）小喊咬基]丙氧基 ]-3.曱氧基苯基]乙醯綱或其^藥學可接受之酸加成鹽及 至少一種醫藥學載劑或稀釋劑。 3· —種1-[4，[3-[4_(6-氟·1>2•笨異噚吐_3基）小味咬基]丙 氧基]-3-曱氧基苯基]乙醯鲷或其醫藥學可接受之酸加 成鹽之用途，其係用於製備治療兩極性失調症之醫藥組 合物。 修五 -S ir：裝76067-981124.doc 本纸張尺度適用中國國家標準(CNS) Α4規格(210X297公爱)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0102841.4A GB0102841D0 (en) | 2001-02-05 | 2001-02-05 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TWI322011B true TWI322011B (en) | 2010-03-21 |
Family
ID=9908143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW091101815A TWI322011B (en) | 2001-02-05 | 2002-02-01 | New use of iloperidone |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US20040072869A1 (zh) |
| EP (1) | EP1370262A1 (zh) |
| JP (1) | JP4278981B2 (zh) |
| KR (1) | KR100851256B1 (zh) |
| CN (1) | CN1226035C (zh) |
| AU (1) | AU2002231766B2 (zh) |
| BR (1) | BR0206918A (zh) |
| CA (1) | CA2434900C (zh) |
| CZ (1) | CZ301357B6 (zh) |
| GB (1) | GB0102841D0 (zh) |
| HU (1) | HUP0303136A3 (zh) |
| IL (3) | IL156819A0 (zh) |
| MX (1) | MXPA03006970A (zh) |
| NO (1) | NO20033163L (zh) |
| NZ (1) | NZ527111A (zh) |
| PL (1) | PL362550A1 (zh) |
| RU (1) | RU2301065C2 (zh) |
| SK (1) | SK9812003A3 (zh) |
| TW (1) | TWI322011B (zh) |
| WO (1) | WO2002064141A1 (zh) |
| ZA (1) | ZA200305331B (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005292246B2 (en) | 2004-09-30 | 2011-07-07 | Vanda Pharmaceuticals, Inc | Methods for the administration of iloperidone |
| US20100063093A1 (en) | 2007-03-28 | 2010-03-11 | Curt Wolfgang | Methods for the administration of iloperidone |
| RU2008150624A (ru) * | 2006-05-22 | 2010-06-27 | Ванда Фармасьютиклз, Инк. (Us) | Лечение депрессивных расстройств |
| CN101822673B (zh) * | 2009-03-04 | 2013-09-18 | 北京德众万全药物技术开发有限公司 | 一种含有伊潘立酮的固体药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE126512T1 (de) * | 1989-05-19 | 1995-09-15 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| CA2300148C (en) * | 1997-08-11 | 2009-06-23 | University Of South Florida | Nicotine antagonists for nicotine-responsive neuropsychiatric disorders |
| US5955459A (en) * | 1997-11-26 | 1999-09-21 | Neuromedica, Inc. | Fatty acid-antipsychotic compositions and uses thereof |
| KR20010072878A (ko) * | 1998-10-16 | 2001-07-31 | 디르크 반테 | 인식을 개선하기 위한 아세틸콜린에스테라제 억제제와배합된 비정형 항정신병제 |
| EP1242058A1 (en) * | 1999-04-07 | 2002-09-25 | Pfizer Products Inc. | Use of cyp2d6 inhibitors in combination therapies |
-
2001
- 2001-02-05 GB GBGB0102841.4A patent/GB0102841D0/en not_active Ceased
-
2002
- 2002-02-01 TW TW091101815A patent/TWI322011B/zh not_active IP Right Cessation
- 2002-02-04 CN CNB028043669A patent/CN1226035C/zh not_active Expired - Lifetime
- 2002-02-04 MX MXPA03006970A patent/MXPA03006970A/es active IP Right Grant
- 2002-02-04 CZ CZ20032114A patent/CZ301357B6/cs not_active IP Right Cessation
- 2002-02-04 JP JP2002563935A patent/JP4278981B2/ja not_active Expired - Lifetime
- 2002-02-04 KR KR1020037009134A patent/KR100851256B1/ko not_active IP Right Cessation
- 2002-02-04 US US10/470,499 patent/US20040072869A1/en not_active Abandoned
- 2002-02-04 EP EP02711828A patent/EP1370262A1/en not_active Withdrawn
- 2002-02-04 CA CA2434900A patent/CA2434900C/en not_active Expired - Fee Related
- 2002-02-04 SK SK981-2003A patent/SK9812003A3/sk not_active Application Discontinuation
- 2002-02-04 WO PCT/EP2002/001130 patent/WO2002064141A1/en active Application Filing
- 2002-02-04 PL PL02362550A patent/PL362550A1/xx not_active Application Discontinuation
- 2002-02-04 AU AU2002231766A patent/AU2002231766B2/en not_active Expired
- 2002-02-04 RU RU2003126175/15A patent/RU2301065C2/ru not_active IP Right Cessation
- 2002-02-04 BR BR0206918-0A patent/BR0206918A/pt not_active Application Discontinuation
- 2002-02-04 NZ NZ527111A patent/NZ527111A/en unknown
- 2002-02-04 HU HU0303136A patent/HUP0303136A3/hu unknown
- 2002-02-04 IL IL15681902A patent/IL156819A0/xx active IP Right Grant
-
2003
- 2003-07-07 IL IL156819A patent/IL156819A/en not_active IP Right Cessation
- 2003-07-10 NO NO20033163A patent/NO20033163L/no not_active Application Discontinuation
- 2003-07-10 ZA ZA200305331A patent/ZA200305331B/en unknown
-
2006
- 2006-05-04 US US11/418,507 patent/US20060205786A1/en not_active Abandoned
-
2007
- 2007-12-21 US US11/962,893 patent/US20080103177A1/en not_active Abandoned
- 2007-12-27 IL IL188485A patent/IL188485A0/en not_active IP Right Cessation
-
2009
- 2009-01-23 US US12/358,959 patent/US20090131477A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090131477A1 (en) | 2009-05-21 |
| NZ527111A (en) | 2005-05-27 |
| CZ20032114A3 (cs) | 2004-01-14 |
| EP1370262A1 (en) | 2003-12-17 |
| JP2004517959A (ja) | 2004-06-17 |
| IL156819A0 (en) | 2004-02-08 |
| NO20033163D0 (no) | 2003-07-10 |
| IL156819A (en) | 2008-03-20 |
| RU2003126175A (ru) | 2005-03-10 |
| CN1226035C (zh) | 2005-11-09 |
| SK9812003A3 (en) | 2004-04-06 |
| HUP0303136A2 (hu) | 2003-12-29 |
| AU2002231766B2 (en) | 2005-12-22 |
| US20040072869A1 (en) | 2004-04-15 |
| WO2002064141A1 (en) | 2002-08-22 |
| CA2434900C (en) | 2010-10-05 |
| ZA200305331B (en) | 2004-05-12 |
| HUP0303136A3 (en) | 2006-05-29 |
| CA2434900A1 (en) | 2002-08-22 |
| CZ301357B6 (cs) | 2010-01-27 |
| NO20033163L (no) | 2003-07-10 |
| CN1531432A (zh) | 2004-09-22 |
| US20060205786A1 (en) | 2006-09-14 |
| MXPA03006970A (es) | 2003-11-18 |
| PL362550A1 (en) | 2004-11-02 |
| IL188485A0 (en) | 2008-03-20 |
| GB0102841D0 (en) | 2001-03-21 |
| US20080103177A1 (en) | 2008-05-01 |
| BR0206918A (pt) | 2004-02-03 |
| RU2301065C2 (ru) | 2007-06-20 |
| KR20030070599A (ko) | 2003-08-30 |
| KR100851256B1 (ko) | 2008-08-08 |
| JP4278981B2 (ja) | 2009-06-17 |
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| MK4A | Expiration of patent term of an invention patent |