TWI301760B - Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors - Google Patents

Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors Download PDF

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Publication number
TWI301760B
TWI301760B TW094105679A TW94105679A TWI301760B TW I301760 B TWI301760 B TW I301760B TW 094105679 A TW094105679 A TW 094105679A TW 94105679 A TW94105679 A TW 94105679A TW I301760 B TWI301760 B TW I301760B
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Taiwan
Prior art keywords
dihydro
quinolin
dimethyl
keto
group
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TW094105679A
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English (en)
Chinese (zh)
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TW200534857A (en
Inventor
Aigars Jirgensons
Christopher Graham Raphael Parsons
Ieva Jaunzeme
Ivars Kalvinsh
Markus Henrich
Maksims Vanejevs
Tanja Weil
Valerjans Kauss
Wojciech Danysz
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Merz Pharma Gmbh & Co Kgaa
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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TW094105679A 2004-02-27 2005-02-24 Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors TWI301760B (en)

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US54878804P 2004-02-27 2004-02-27

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US7598384B2 (en) 2009-10-06
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CA2556653C (en) 2011-08-16
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TW200534857A (en) 2005-11-01
EA010656B1 (ru) 2008-10-30
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UY28775A1 (es) 2005-04-29
WO2005082856A3 (en) 2005-11-24
IL177524A (en) 2012-02-29
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BRPI0508225A (pt) 2007-07-17
AU2005217199B2 (en) 2008-06-26
US20050197361A1 (en) 2005-09-08
EA200601556A1 (ru) 2007-02-27
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ATE409182T1 (de) 2008-10-15
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AR049006A1 (es) 2006-06-21
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