DE602005009929D1 - Tetrahydrochinolinone und deren verwendung als antagonisten von metabotropen glutamatrezeptoren - Google Patents
Tetrahydrochinolinone und deren verwendung als antagonisten von metabotropen glutamatrezeptorenInfo
- Publication number
- DE602005009929D1 DE602005009929D1 DE602005009929T DE602005009929T DE602005009929D1 DE 602005009929 D1 DE602005009929 D1 DE 602005009929D1 DE 602005009929 T DE602005009929 T DE 602005009929T DE 602005009929 T DE602005009929 T DE 602005009929T DE 602005009929 D1 DE602005009929 D1 DE 602005009929D1
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydrochinolinone
- antagonists
- metabotropic glutamate
- glutamate receptors
- receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C07—ORGANIC CHEMISTRY
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54878804P | 2004-02-27 | 2004-02-27 | |
PCT/GB2005/000717 WO2005082856A2 (en) | 2004-02-27 | 2005-02-25 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005009929D1 true DE602005009929D1 (de) | 2008-11-06 |
Family
ID=34911013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005009929T Active DE602005009929D1 (de) | 2004-02-27 | 2005-02-25 | Tetrahydrochinolinone und deren verwendung als antagonisten von metabotropen glutamatrezeptoren |
Country Status (23)
Country | Link |
---|---|
US (1) | US7598384B2 (de) |
EP (1) | EP1723116B1 (de) |
JP (1) | JP4712027B2 (de) |
KR (1) | KR100846347B1 (de) |
CN (1) | CN1922146A (de) |
AR (1) | AR049006A1 (de) |
AT (1) | ATE409182T1 (de) |
AU (1) | AU2005217199B2 (de) |
BR (1) | BRPI0508225A (de) |
CA (1) | CA2556653C (de) |
DE (1) | DE602005009929D1 (de) |
DK (1) | DK1723116T3 (de) |
EA (1) | EA010656B1 (de) |
ES (1) | ES2315853T3 (de) |
IL (1) | IL177524A (de) |
PL (1) | PL1723116T3 (de) |
PT (1) | PT1723116E (de) |
SI (1) | SI1723116T1 (de) |
TW (1) | TWI301760B (de) |
UA (1) | UA83549C2 (de) |
UY (1) | UY28775A1 (de) |
WO (1) | WO2005082856A2 (de) |
ZA (1) | ZA200606686B (de) |
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EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
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JP2010502722A (ja) | 2006-09-08 | 2010-01-28 | ブレインセルス,インコーポレイティド | 4−アシルアミノピリジン誘導体を含む組み合わせ |
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KR101450356B1 (ko) | 2006-11-24 | 2014-10-15 | 에이씨 이뮨 에스.에이. | 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 n-(메틸)-1h-피라졸-3-아민, n-(메틸)-피리딘-2-아민 및 n-(메틸)-티아졸-2-아민 유도체 |
CA2742897A1 (en) * | 2008-11-06 | 2010-05-14 | Astrazeneca Ab | Modulators of amyloid beta. |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
EP2311823A1 (de) | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridinverbindungen zur Behandlung von Krankheiten im Zusammenhang mit Amyloidproteinen oder zur Behandlung von Augenkrankheiten |
BR112012014436A2 (pt) | 2009-12-18 | 2019-09-24 | Janssen Pharmaceutica Nv | tiazóis bicíclicos como moduladores alostéricos de receptores mglur5 |
JP5763673B2 (ja) | 2009-12-18 | 2015-08-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプJanssen Pharmaceutica Naamloze Vennootschap | mGluR5受容体のアロステリック調節因子としての二環式チアゾール |
GB0922589D0 (en) * | 2009-12-23 | 2010-02-10 | Almac Discovery Ltd | Pharmaceutical compounds |
WO2012052451A1 (en) | 2010-10-18 | 2012-04-26 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
CN103298789A (zh) * | 2010-11-16 | 2013-09-11 | 通用电气健康护理有限公司 | 作为τ蛋白病理成像探针的杂环化合物 |
WO2012139876A1 (en) | 2011-04-14 | 2012-10-18 | Merz Pharma Gmbh & Co. Kgaa | Enteric formulations of metabotropic glutamate receptor modulators |
AU2013309868A1 (en) * | 2012-08-30 | 2015-03-12 | Nippon Shinyaku Co., Ltd. | Pyridine derivative and medicine |
EP2951157A1 (de) * | 2013-02-04 | 2015-12-09 | Merck Patent GmbH | Positive allosterische modulatoren von mglur3 |
CN104513200B (zh) * | 2013-09-26 | 2017-05-03 | 江苏苏中药业集团股份有限公司 | 取代丁烯酰胺的马来酸盐及其晶型 |
TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
MY189194A (en) | 2015-05-15 | 2022-01-31 | Aurigene Discovery Tech Ltd | Substituted tetrahydroquinolinone compounds as ror gamma modulators |
KR20180070695A (ko) * | 2015-10-29 | 2018-06-26 | 이펙터 테라퓨틱스, 인크. | Mnk1 및 mnk2의 이소인돌린, 아자이소인돌린, 디히드로인데논 및 디히드로아자인데논 억제제 |
WO2017087808A1 (en) | 2015-11-20 | 2017-05-26 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers |
WO2017189553A1 (en) * | 2016-04-25 | 2017-11-02 | Everon Biosciences, Inc. | Removal of senescence-associated macrophages |
SG11201907356SA (en) | 2017-02-14 | 2019-09-27 | Effector Therapeutics Inc | Piperidine-substituted mnk inhibitors and methods related thereto |
EP3870178A4 (de) | 2018-10-24 | 2022-08-03 | Effector Therapeutics Inc. | Kristalline formen von mnk-inhibitoren |
WO2023250480A1 (en) * | 2022-06-23 | 2023-12-28 | The Cleveland Clinic Foundation | 3-βHSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF |
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US3501479A (en) * | 1967-05-19 | 1970-03-17 | American Cyanamid Co | Dihydroquinolines and substituted dihydroquinolines and method of preparing the same |
DE2001572A1 (de) | 1970-01-15 | 1971-07-22 | Agfa Gevaert Ag | Spektral sensibilisiertes lichtempfindliches Material |
DE2449030A1 (de) | 1974-10-11 | 1976-05-20 | Schering Ag | Neue pyridin-derivate |
WO1988002251A1 (en) | 1986-09-26 | 1988-04-07 | Ici Australia Operations Proprietary Limited | Sunscreen compositions and compounds for use therein |
US5216164A (en) * | 1990-12-03 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds |
US5110815A (en) * | 1990-12-03 | 1992-05-05 | Hoechst-Roussel Pharmaceuticals Inc. | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use |
CA2316944A1 (en) * | 1998-02-20 | 1999-08-26 | Mitsuru Shiraishi | Aminoguanidinehydrazone derivative, production and use thereof |
GB0003632D0 (en) | 2000-02-16 | 2000-04-05 | Univ Hong Kong Science & Techn | Dimeric compounds |
AU2001293847B2 (en) * | 2000-10-02 | 2007-05-24 | Janssen Pharmaceutica N.V. | Metabotropic glutamate receptor antagonists |
KR101061561B1 (ko) | 2002-03-29 | 2011-09-02 | 얀센 파마슈티카 엔.브이. | 대사자극성 글루타메이트 수용체 리간드로서 방사능표지된 퀴놀린 및 퀴놀리논 유도체 및 그의 용도 |
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Also Published As
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EP1723116B1 (de) | 2008-09-24 |
US20050197361A1 (en) | 2005-09-08 |
DK1723116T3 (da) | 2009-02-02 |
ZA200606686B (en) | 2008-01-30 |
EA010656B1 (ru) | 2008-10-30 |
CN1922146A (zh) | 2007-02-28 |
UY28775A1 (es) | 2005-04-29 |
EA200601556A1 (ru) | 2007-02-27 |
WO2005082856A3 (en) | 2005-11-24 |
PT1723116E (pt) | 2009-01-02 |
AU2005217199B2 (en) | 2008-06-26 |
CA2556653C (en) | 2011-08-16 |
JP2007524710A (ja) | 2007-08-30 |
TWI301760B (en) | 2008-10-11 |
ATE409182T1 (de) | 2008-10-15 |
SI1723116T1 (sl) | 2009-04-30 |
EP1723116A2 (de) | 2006-11-22 |
AU2005217199A1 (en) | 2005-09-09 |
ES2315853T3 (es) | 2009-04-01 |
KR20070001975A (ko) | 2007-01-04 |
CA2556653A1 (en) | 2005-09-09 |
WO2005082856A2 (en) | 2005-09-09 |
UA83549C2 (uk) | 2008-07-25 |
BRPI0508225A (pt) | 2007-07-17 |
PL1723116T3 (pl) | 2009-04-30 |
IL177524A (en) | 2012-02-29 |
AR049006A1 (es) | 2006-06-21 |
IL177524A0 (en) | 2006-12-10 |
TW200534857A (en) | 2005-11-01 |
KR100846347B1 (ko) | 2008-07-15 |
JP4712027B2 (ja) | 2011-06-29 |
US7598384B2 (en) | 2009-10-06 |
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