ES2315853T3 - Tetrahidroquinolinonas y su uso como antagonistas de receptores de glutamato metabotropico. - Google Patents
Tetrahidroquinolinonas y su uso como antagonistas de receptores de glutamato metabotropico. Download PDFInfo
- Publication number
- ES2315853T3 ES2315853T3 ES05717798T ES05717798T ES2315853T3 ES 2315853 T3 ES2315853 T3 ES 2315853T3 ES 05717798 T ES05717798 T ES 05717798T ES 05717798 T ES05717798 T ES 05717798T ES 2315853 T3 ES2315853 T3 ES 2315853T3
- Authority
- ES
- Spain
- Prior art keywords
- aryl
- 6alkyl
- dihydro
- heteroaryl
- 6alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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- C07D221/04—Ortho- or peri-condensed ring systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
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- Physical Education & Sports Medicine (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54878804P | 2004-02-27 | 2004-02-27 | |
| US548788P | 2004-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2315853T3 true ES2315853T3 (es) | 2009-04-01 |
Family
ID=34911013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05717798T Expired - Lifetime ES2315853T3 (es) | 2004-02-27 | 2005-02-25 | Tetrahidroquinolinonas y su uso como antagonistas de receptores de glutamato metabotropico. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7598384B2 (de) |
| EP (1) | EP1723116B1 (de) |
| JP (1) | JP4712027B2 (de) |
| KR (1) | KR100846347B1 (de) |
| CN (1) | CN1922146A (de) |
| AR (1) | AR049006A1 (de) |
| AT (1) | ATE409182T1 (de) |
| AU (1) | AU2005217199B2 (de) |
| BR (1) | BRPI0508225A (de) |
| CA (1) | CA2556653C (de) |
| DE (1) | DE602005009929D1 (de) |
| DK (1) | DK1723116T3 (de) |
| EA (1) | EA010656B1 (de) |
| ES (1) | ES2315853T3 (de) |
| IL (1) | IL177524A (de) |
| PL (1) | PL1723116T3 (de) |
| PT (1) | PT1723116E (de) |
| SI (1) | SI1723116T1 (de) |
| TW (1) | TWI301760B (de) |
| UA (1) | UA83549C2 (de) |
| UY (1) | UY28775A1 (de) |
| WO (1) | WO2005082856A2 (de) |
| ZA (1) | ZA200606686B (de) |
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| WO2007023242A1 (en) * | 2005-08-24 | 2007-03-01 | Merz Pharma Gmbh & Co. Kgaa | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors |
| WO2007023245A1 (en) * | 2005-08-25 | 2007-03-01 | Merz Pharma Gmbh & Co. Kgaa | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors |
| AU2006282896A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2258357A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| AU2006303037A1 (en) * | 2005-10-21 | 2007-04-26 | Merz Pharma Gmbh & Co Kgaa | Chromenones and their use as modulators of metabotropic glutamate receptors |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス,インコーポレイティド | 神経発生のgaba受容体媒介調節 |
| AR057218A1 (es) * | 2005-12-15 | 2007-11-21 | Astra Ab | Compuestos de oxazolidinona y su uso como pontenciadores del receptor metabotropico de glutamato |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
| US7998971B2 (en) | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| CA2670418A1 (en) * | 2006-11-24 | 2008-05-29 | Ac Immune Sa | N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimers's |
| EP2367826A4 (de) * | 2008-11-06 | 2012-07-04 | Astrazeneca Ab | Amyloid-beta-modulatoren |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| EP2311823A1 (de) | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridinverbindungen zur Behandlung von Krankheiten im Zusammenhang mit Amyloidproteinen oder zur Behandlung von Augenkrankheiten |
| CN102666551B (zh) | 2009-12-18 | 2014-12-10 | 詹森药业有限公司 | 作为mglur5受体的变构调节剂的双环噻唑 |
| CA2782950A1 (en) | 2009-12-18 | 2011-06-23 | Janssen Pharmaceutica Nv | Bicyclic thiazoles as allosteric modulators of mglur5 receptors |
| GB0922589D0 (en) * | 2009-12-23 | 2010-02-10 | Almac Discovery Ltd | Pharmaceutical compounds |
| AR083475A1 (es) | 2010-10-18 | 2013-02-27 | Merz Pharma Gmbh & Co Kgaa | Moduladores de receptores de glutamato metabotropicos |
| US9040021B2 (en) * | 2010-11-16 | 2015-05-26 | Ge Healthcare Limited | Heterocyclic compounds as imaging probes of tau pathology |
| WO2012139876A1 (en) | 2011-04-14 | 2012-10-18 | Merz Pharma Gmbh & Co. Kgaa | Enteric formulations of metabotropic glutamate receptor modulators |
| CA2881638A1 (en) * | 2012-08-30 | 2014-03-06 | Nippon Shinyaku Co., Ltd. | Pyridine derivative and medicine |
| US10059671B2 (en) | 2013-02-04 | 2018-08-28 | Prexton Therapeutics Sa | Positive allosteric modulators of mGluR3 |
| CN104513200B (zh) * | 2013-09-26 | 2017-05-03 | 江苏苏中药业集团股份有限公司 | 取代丁烯酰胺的马来酸盐及其晶型 |
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
| HRP20210745T1 (hr) | 2015-05-15 | 2021-06-25 | Aurigene Discovery Technologies Limited | Supstituirani spojevi tetrahidrokinolinona kao ror gama modulatori |
| CA3002877A1 (en) * | 2015-10-29 | 2017-05-04 | Effector Therapeutics, Inc. | Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of mnk1 and mnk2 |
| US10000487B2 (en) | 2015-11-20 | 2018-06-19 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers |
| US20200123127A1 (en) * | 2016-04-25 | 2020-04-23 | Everon Biosciences, Inc. | Removal of senescence-associated macrophages |
| EP3582776B1 (de) | 2017-02-14 | 2023-11-08 | Effector Therapeutics, Inc. | Piperidinsubstituierte mnk-inhibitoren und zugehörige verfahren |
| KR20210102211A (ko) | 2018-10-24 | 2021-08-19 | 이펙터 테라퓨틱스, 인크. | Mnk 억제제의 결정질 형태 |
| GB2600384A (en) | 2020-09-30 | 2022-05-04 | Vaderis Therapeutics Ag | Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia |
| EP4543437A1 (de) * | 2022-06-23 | 2025-04-30 | The Cleveland Clinic Foundation | 3-?hsd1-inhibitoren sowie zusammensetzungen und verwendungen davon |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3501479A (en) * | 1967-05-19 | 1970-03-17 | American Cyanamid Co | Dihydroquinolines and substituted dihydroquinolines and method of preparing the same |
| DE2001572A1 (de) | 1970-01-15 | 1971-07-22 | Agfa Gevaert Ag | Spektral sensibilisiertes lichtempfindliches Material |
| DE2449030A1 (de) | 1974-10-11 | 1976-05-20 | Schering Ag | Neue pyridin-derivate |
| WO1988002251A1 (en) | 1986-09-26 | 1988-04-07 | Ici Australia Operations Proprietary Limited | Sunscreen compositions and compounds for use therein |
| US5110815A (en) * | 1990-12-03 | 1992-05-05 | Hoechst-Roussel Pharmaceuticals Inc. | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use |
| US5216164A (en) * | 1990-12-03 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds |
| CN1290249A (zh) * | 1998-02-20 | 2001-04-04 | 武田药品工业株式会社 | 氨基胍腙衍生物、制法及制剂 |
| GB0003632D0 (en) | 2000-02-16 | 2000-04-05 | Univ Hong Kong Science & Techn | Dimeric compounds |
| US7115630B2 (en) | 2000-10-02 | 2006-10-03 | Janssen Pharmaceutica N.V. | Metabotropic glutamate receptor antagonists |
| EP1492571A2 (de) * | 2002-03-29 | 2005-01-05 | Janssen Pharmaceutica N.V. | Radioaktiv markierte chinolin- und chinolinon-derivate und ihre verwendung als metabotrope glutamat-rezeptor-liganden |
-
2005
- 2005-02-24 TW TW094105679A patent/TWI301760B/zh not_active IP Right Cessation
- 2005-02-25 JP JP2007500295A patent/JP4712027B2/ja not_active Expired - Fee Related
- 2005-02-25 UA UAA200610294A patent/UA83549C2/uk unknown
- 2005-02-25 AR ARP050100694A patent/AR049006A1/es unknown
- 2005-02-25 AT AT05717798T patent/ATE409182T1/de active
- 2005-02-25 CA CA2556653A patent/CA2556653C/en not_active Expired - Fee Related
- 2005-02-25 US US11/066,899 patent/US7598384B2/en not_active Expired - Fee Related
- 2005-02-25 AU AU2005217199A patent/AU2005217199B2/en not_active Ceased
- 2005-02-25 EA EA200601556A patent/EA010656B1/ru not_active IP Right Cessation
- 2005-02-25 PT PT05717798T patent/PT1723116E/pt unknown
- 2005-02-25 UY UY28775A patent/UY28775A1/es unknown
- 2005-02-25 SI SI200530520T patent/SI1723116T1/sl unknown
- 2005-02-25 CN CNA2005800060497A patent/CN1922146A/zh active Pending
- 2005-02-25 EP EP05717798A patent/EP1723116B1/de not_active Expired - Lifetime
- 2005-02-25 PL PL05717798T patent/PL1723116T3/pl unknown
- 2005-02-25 KR KR1020067017249A patent/KR100846347B1/ko not_active Expired - Fee Related
- 2005-02-25 BR BRPI0508225-0A patent/BRPI0508225A/pt not_active Application Discontinuation
- 2005-02-25 ES ES05717798T patent/ES2315853T3/es not_active Expired - Lifetime
- 2005-02-25 DE DE602005009929T patent/DE602005009929D1/de not_active Expired - Lifetime
- 2005-02-25 WO PCT/GB2005/000717 patent/WO2005082856A2/en not_active Ceased
- 2005-02-25 DK DK05717798T patent/DK1723116T3/da active
-
2006
- 2006-08-11 ZA ZA200606686A patent/ZA200606686B/xx unknown
- 2006-08-16 IL IL177524A patent/IL177524A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1723116B1 (de) | 2008-09-24 |
| CA2556653A1 (en) | 2005-09-09 |
| TWI301760B (en) | 2008-10-11 |
| EP1723116A2 (de) | 2006-11-22 |
| KR100846347B1 (ko) | 2008-07-15 |
| SI1723116T1 (sl) | 2009-04-30 |
| AU2005217199B2 (en) | 2008-06-26 |
| BRPI0508225A (pt) | 2007-07-17 |
| CN1922146A (zh) | 2007-02-28 |
| IL177524A (en) | 2012-02-29 |
| AU2005217199A1 (en) | 2005-09-09 |
| ATE409182T1 (de) | 2008-10-15 |
| US7598384B2 (en) | 2009-10-06 |
| ZA200606686B (en) | 2008-01-30 |
| WO2005082856A2 (en) | 2005-09-09 |
| TW200534857A (en) | 2005-11-01 |
| AR049006A1 (es) | 2006-06-21 |
| JP4712027B2 (ja) | 2011-06-29 |
| EA010656B1 (ru) | 2008-10-30 |
| PT1723116E (pt) | 2009-01-02 |
| WO2005082856A3 (en) | 2005-11-24 |
| DE602005009929D1 (de) | 2008-11-06 |
| UA83549C2 (uk) | 2008-07-25 |
| CA2556653C (en) | 2011-08-16 |
| EA200601556A1 (ru) | 2007-02-27 |
| US20050197361A1 (en) | 2005-09-08 |
| JP2007524710A (ja) | 2007-08-30 |
| DK1723116T3 (da) | 2009-02-02 |
| KR20070001975A (ko) | 2007-01-04 |
| UY28775A1 (es) | 2005-04-29 |
| IL177524A0 (en) | 2006-12-10 |
| PL1723116T3 (pl) | 2009-04-30 |
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