AR040694A1 - Derivados de benzodioxol como antagonistas de los receptores cb1 - Google Patents
Derivados de benzodioxol como antagonistas de los receptores cb1Info
- Publication number
- AR040694A1 AR040694A1 AR20030102682A ARP030102682A AR040694A1 AR 040694 A1 AR040694 A1 AR 040694A1 AR 20030102682 A AR20030102682 A AR 20030102682A AR P030102682 A ARP030102682 A AR P030102682A AR 040694 A1 AR040694 A1 AR 040694A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- lower alkyl
- hydroxy
- independently
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P25/34—Tobacco-abuse
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
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- Urology & Nephrology (AREA)
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- Psychology (AREA)
- Virology (AREA)
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- Nutrition Science (AREA)
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- Pregnancy & Childbirth (AREA)
Abstract
Reivindicación 1: Compuestos de la fórmula (1) en la que R1 y R2 con independencia entre sí son fenilo sin sustituir o fenilo mono-, di-, o trisustituido, con independencia entre sí, por hidroxi, alquilo inferior, alcoxi inferior, perfluor-alquilo inferior, alcanoilo, ciano o halógeno; R3 y R4 con independencia entre sí son H, halógeno, hidroxi, alquilo inferior, alcoxi inferior, perfluoralquilo inferior, alcanoilo o ciano; R5 es H o alquilo inferior; R6 es fenilo o fenil-alquilo inferior, en los que el resto fenilo puede estar eventualmente mono-, di- o trisustituido, con independencia entre sí, por alquilo inferior, alcoxi inferior, halógeno, perfluoralquilo inferior, hidroxi, alcanoilo o ciano; o R5 y R6 junto con el átomo de N al que están unidos forman un anillo heterocíclico saturado o insaturado, monocíclico de 5, 6 o 7 eslabones o bicíclico de 9 o 10 eslabones, que puede llevar eventualmente uno o dos heteroátomos adicionales, elegidos con independencia entre sí entre O, N y S, dicho anillo heterocíclico puede estar eventualmente mono-, di-, o trisustituido, con independencia entre sí, por alquilo inferior,(alcoxi inferior)carbonilo, hidroxi-alquilo inferior, alcanoilo, amino-alquilo inferior, hidroxi, alcoxi inferior, halógeno, perfluoralquilo inferior, ciano, heteroarilo, o por fenilo o fenil-alquilo inferior, en los que el resto fenilo puede estar eventualmente mono-, di-, o trisustituido, con independencia entre sí, por alquilo inferior, alcoxi inferior, halógeno, perfluor-alquilo inferior, hidroxi, alcanoilo o ciano. X es -CH2-, -C(O)- o -SO2-; y las sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02016831 | 2002-07-29 |
Publications (1)
Publication Number | Publication Date |
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AR040694A1 true AR040694A1 (es) | 2005-04-13 |
Family
ID=31197779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20030102682A AR040694A1 (es) | 2002-07-29 | 2003-07-25 | Derivados de benzodioxol como antagonistas de los receptores cb1 |
Country Status (25)
Country | Link |
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US (2) | US6900227B2 (es) |
EP (1) | EP1532132B1 (es) |
JP (1) | JP4202319B2 (es) |
KR (1) | KR100741231B1 (es) |
CN (1) | CN100486973C (es) |
AR (1) | AR040694A1 (es) |
AT (1) | ATE389646T1 (es) |
AU (1) | AU2003250117B2 (es) |
BR (1) | BR0313041A (es) |
CA (1) | CA2493313C (es) |
DE (1) | DE60319837T2 (es) |
ES (1) | ES2301833T3 (es) |
HR (1) | HRP20050044A2 (es) |
IL (1) | IL166084A (es) |
MX (1) | MXPA05000962A (es) |
MY (1) | MY135841A (es) |
NZ (1) | NZ537685A (es) |
PA (1) | PA8578601A1 (es) |
PE (1) | PE20040720A1 (es) |
PL (1) | PL375441A1 (es) |
RU (1) | RU2304580C2 (es) |
TW (1) | TW200413345A (es) |
UY (1) | UY27918A1 (es) |
WO (1) | WO2004013120A1 (es) |
ZA (1) | ZA200500340B (es) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7365093B2 (en) * | 1994-08-19 | 2008-04-29 | Abbott Laboratories | Endothelin antagonists |
EP1558252B1 (en) | 2002-08-02 | 2007-10-10 | Merck & Co., Inc. | Substituted furo [2,3-b]pyridine derivatives |
CA2553970A1 (en) * | 2004-01-28 | 2005-08-18 | F. Hoffmann-La Roche Ag | Spiro-benzodioxoles and their use as cb1 antagonists |
US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
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