AR049894A1 - Derivados de prolina y sus usos como inhibodores de la enzima dipeptidilpeptidasa-iv - Google Patents

Derivados de prolina y sus usos como inhibodores de la enzima dipeptidilpeptidasa-iv

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Publication number
AR049894A1
AR049894A1 ARP050101880A ARP050101880A AR049894A1 AR 049894 A1 AR049894 A1 AR 049894A1 AR P050101880 A ARP050101880 A AR P050101880A AR P050101880 A ARP050101880 A AR P050101880A AR 049894 A1 AR049894 A1 AR 049894A1
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AR
Argentina
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alkyl
cyano
alkoxy
halogen
nrarb
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ARP050101880A
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Pfizer Prod Inc
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Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR049894A1 publication Critical patent/AR049894A1/es

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Abstract

La presente se refiere a derivados de prolina y sus usos como inhibidores de la enzima dipeptidil-peptidasa-IV; composiciones de los mismos, y usos de los mismos en tratar complicaciones diabéticas incluyendo neuropatía diabética, nefropatía diabética, microangiopatía diabética, y similares. Reivindicacion 1: Un compuesto de formula (1) o un profármaco del mismo, o una sal farmacéuticamente aceptable de dicho compuesto o profármaco, o un solvato de dicho compuesto, profármaco o sal, en el que: R1 es -alquilo C1-6, -alcoxi C1-6, -arilalquilo C1-6, -NRaRb, hidroxi, ciano, arilo, o heteroarilo, en los que dicho -alquilo C1-6, dicho arilo, o dicho heteroarilo está sustituido opcionalmente de forma independiente con de uno a tres - COOH, -C(O)alcoxi C1-6, -C(O)alquilo C1-6, -C(O)NRaRb, ciano, halogeno, nitro, trifluorometilo, -alquilo C1-6, -alcoxi C1-6, -cicloalquilo C3-6, o fenilo, en el que: Ra y Rb son, independientemente, H, -alquilo C1-6, arilo, o heteroarilo, o Ra y Rb, tomados conjuntamente con el átomo de N al cual están unidos, forman un anillo heterocíclico de cuatro a seis miembros, en el que dicho anillo heterocíclico incorpora opcionalmente uno o dos heteroátomos de anillo adicionales de N, O, o S; R2 y R3 son, independientemente, H, halogeno, -alquilo C1-6 o -cicloalquilo C3-8; Q es un enlace covalente, -C(O)-, o -SO2-; Het es un resto heterocicloalquilo, sustituido opcionalmente con (A) de uno a cuatro -alquilo C1-6, sustituidos opcionalmente con de uno a seis átomos de halogeno, -alcoxi C1-6, ciano, halogeno, hidroxi, o NRaRb, o (B) -arilalquilo C1-6, sustituido opcionalmente con de uno a seis átomos de halogeno, -alcoxi C1-6, ciano, halogeno, hidroxi, o -NRaRb; n es 0 o 1; cuando n es 0, X es -CH2-, e Y es -CH2-, -CHF-, o -CF2-; o cuando n es 1, X es -CH2-, -CHF-, o -CF2- e Y es -CH2-, -CHF-, o -CF2-, con la condicion de que X e Y no son ambos -CH2-; y Z es H o ciano.
ARP050101880A 2004-05-12 2005-05-10 Derivados de prolina y sus usos como inhibodores de la enzima dipeptidilpeptidasa-iv AR049894A1 (es)

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US57030004P 2004-05-12 2004-05-12
US66430505P 2005-03-21 2005-03-21

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AR049894A1 true AR049894A1 (es) 2006-09-13

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