BR112012014436A2 - tiazóis bicíclicos como moduladores alostéricos de receptores mglur5 - Google Patents
tiazóis bicíclicos como moduladores alostéricos de receptores mglur5Info
- Publication number
- BR112012014436A2 BR112012014436A2 BR112012014436A BR112012014436A BR112012014436A2 BR 112012014436 A2 BR112012014436 A2 BR 112012014436A2 BR 112012014436 A BR112012014436 A BR 112012014436A BR 112012014436 A BR112012014436 A BR 112012014436A BR 112012014436 A2 BR112012014436 A2 BR 112012014436A2
- Authority
- BR
- Brazil
- Prior art keywords
- mglur5
- allosteric
- receptor modulators
- compounds
- bicyclic thiazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
tiazóis bicíclicos como moduladores alostéricos de receptores mglur5. a presente invenção refere-se a novos tiazóis bicíclicos os quais são moduladores alostéricos positivos do receptor do glutamato metabotrópico subtipo 5 ("mglur5") e os quais são úteis para o tratamento ou a prevenção de distúrbios associados com disfunção de glutamato e doenças nas quais estão envolvidos os receptores do subtipo mglur5. a invenção também se refere a composições farmacêuticas compreendendo os referidos compostos, a processos para preparar os referidos compostos e composições, e à aplicação dos referidos compostos e composições para a prevenção e o tratamento de distúrbios nos quais mglur5 está envolvido.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09179850 | 2009-12-18 | ||
EP10193019 | 2010-11-29 | ||
PCT/EP2010/069957 WO2011073339A1 (en) | 2009-12-18 | 2010-12-16 | Bicyclic thiazoles as allosteric modulators of mglur5 receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012014436A2 true BR112012014436A2 (pt) | 2019-09-24 |
Family
ID=43743677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012014436A BR112012014436A2 (pt) | 2009-12-18 | 2010-12-16 | tiazóis bicíclicos como moduladores alostéricos de receptores mglur5 |
Country Status (19)
Country | Link |
---|---|
US (1) | US9040707B2 (pt) |
EP (1) | EP2513117B1 (pt) |
JP (1) | JP5763672B2 (pt) |
KR (1) | KR20120097400A (pt) |
CN (1) | CN102666552B (pt) |
AR (1) | AR079509A1 (pt) |
AU (1) | AU2010332811B2 (pt) |
BR (1) | BR112012014436A2 (pt) |
CA (1) | CA2782950A1 (pt) |
CL (1) | CL2012001601A1 (pt) |
CO (1) | CO6541615A2 (pt) |
EA (1) | EA019980B1 (pt) |
ES (1) | ES2431302T3 (pt) |
IL (1) | IL220360A (pt) |
MX (1) | MX2012007006A (pt) |
NZ (1) | NZ600605A (pt) |
SG (1) | SG181716A1 (pt) |
WO (1) | WO2011073339A1 (pt) |
ZA (1) | ZA201204433B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2012007006A (es) | 2009-12-18 | 2012-07-03 | Janssen Pharmaceutica Nv | Tiazoles biciclicos como moduladores alostericos de receptores mglur5. |
BR112012014235A2 (pt) | 2009-12-18 | 2016-06-14 | Janssen Pharmaceutica Nv | tiazóis bicíclicos como moduladores alostéricos de receptores mglur5 |
ES2815352T3 (es) * | 2014-02-18 | 2021-03-29 | Daiichi Sankyo Co Ltd | Procedimiento de producción de un inhibidor de factor X de la coagulación sanguínea activado (FXa) |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5753664A (en) | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
JP2002105085A (ja) * | 2000-09-28 | 2002-04-10 | Yamanouchi Pharmaceut Co Ltd | 新規イミダゾチアゾール誘導体 |
WO2004038374A2 (en) | 2002-10-24 | 2004-05-06 | Merck & Co., Inc. | Alkyne derivatives as tracers for metabotropic glutamate receptor binding |
TWI301760B (en) | 2004-02-27 | 2008-10-11 | Merz Pharma Gmbh & Co Kgaa | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors |
ES2333243T3 (es) | 2004-12-17 | 2010-02-18 | Eli Lilly And Company | Derivados de tiazolopiridinona como antagonistas del receptor de mch. |
CA2593439C (en) | 2005-01-14 | 2014-02-25 | F. Hoffmann-La Roche Ag | Thiazole-4-carboxamide derivatives as mglur5 antagonists |
JP2009500442A (ja) * | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | 2型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての2−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
WO2007023242A1 (en) * | 2005-08-24 | 2007-03-01 | Merz Pharma Gmbh & Co. Kgaa | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors |
RU2008122548A (ru) | 2005-11-07 | 2009-12-20 | Айрм Ллк (Bm) | Соединения и композиции, как модуляторы арпп (активированных рецепторов пролифератора пероксисом) |
BRPI0618636A2 (pt) * | 2005-11-08 | 2011-09-06 | Hoffmann La Roche | derivados de tiazolo [4,5-c]piridina |
DE102006011574A1 (de) | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
EP2035436B1 (en) | 2006-06-26 | 2011-05-25 | UCB Pharma S.A. | Fused thiazole derivatives as kinase inhibitors |
EP2049548A1 (en) * | 2006-07-27 | 2009-04-22 | UCB Pharma, S.A. | Fused oxazoles & thiazoles as histamine h3- receptor ligands |
GB0622202D0 (en) | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
EP2094712B1 (en) | 2006-11-15 | 2011-10-12 | Vertex Pharmceuticals Incorporated | Compounds useful as protein kinase inhibitors |
JP4714669B2 (ja) | 2006-12-01 | 2011-06-29 | 日本化薬株式会社 | ヘッダーアッシー、スクイブならびにエアバッグ用ガス発生装置およびシートベルトプリテンショナー用ガス発生装置 |
EP2089397B1 (en) | 2006-12-14 | 2012-08-29 | Eli Lilly & Company | 5- [4- (azetidin-3-yl0xy) -phenyl]-2-phenyl-5h-thiaz0l0 [5,4-c]pyridin-4-0ne derivatives and their use as mch receptor antagonists |
EP2162136A4 (en) | 2007-06-03 | 2012-02-15 | Univ Vanderbilt | POSITIVE ALLOSTERIC MGLUR5 BENZAMIDE MODULATORS AND METHOD FOR THEIR PREPARATION AND USE |
CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
JP5651681B2 (ja) | 2009-04-03 | 2015-01-14 | 大日本住友製薬株式会社 | 代謝型グルタミン酸受容体5介在障害の治療のための化合物、およびその使用方法 |
MX2012007006A (es) | 2009-12-18 | 2012-07-03 | Janssen Pharmaceutica Nv | Tiazoles biciclicos como moduladores alostericos de receptores mglur5. |
CN102753173A (zh) | 2009-12-18 | 2012-10-24 | 贝林格尔.英格海姆国际有限公司 | Hcv组合疗法 |
-
2010
- 2010-12-16 MX MX2012007006A patent/MX2012007006A/es active IP Right Grant
- 2010-12-16 JP JP2012543762A patent/JP5763672B2/ja not_active Expired - Fee Related
- 2010-12-16 ES ES10790574T patent/ES2431302T3/es active Active
- 2010-12-16 US US13/516,985 patent/US9040707B2/en not_active Expired - Fee Related
- 2010-12-16 AU AU2010332811A patent/AU2010332811B2/en not_active Ceased
- 2010-12-16 KR KR1020127018815A patent/KR20120097400A/ko not_active Application Discontinuation
- 2010-12-16 EP EP10790574.7A patent/EP2513117B1/en active Active
- 2010-12-16 BR BR112012014436A patent/BR112012014436A2/pt not_active IP Right Cessation
- 2010-12-16 CA CA2782950A patent/CA2782950A1/en not_active Abandoned
- 2010-12-16 CN CN201080057669.4A patent/CN102666552B/zh not_active Expired - Fee Related
- 2010-12-16 WO PCT/EP2010/069957 patent/WO2011073339A1/en active Application Filing
- 2010-12-16 EA EA201290532A patent/EA019980B1/ru not_active IP Right Cessation
- 2010-12-16 NZ NZ600605A patent/NZ600605A/xx not_active IP Right Cessation
- 2010-12-16 SG SG2012044061A patent/SG181716A1/en unknown
- 2010-12-17 AR ARP100104722A patent/AR079509A1/es not_active Application Discontinuation
-
2012
- 2012-05-29 CO CO12089439A patent/CO6541615A2/es unknown
- 2012-06-13 IL IL220360A patent/IL220360A/en not_active IP Right Cessation
- 2012-06-14 CL CL2012001601A patent/CL2012001601A1/es unknown
- 2012-06-15 ZA ZA2012/04433A patent/ZA201204433B/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG181716A1 (en) | 2012-07-30 |
US20120258955A1 (en) | 2012-10-11 |
MX2012007006A (es) | 2012-07-03 |
JP5763672B2 (ja) | 2015-08-12 |
JP2013514325A (ja) | 2013-04-25 |
CN102666552A (zh) | 2012-09-12 |
EA201290532A1 (ru) | 2012-11-30 |
CA2782950A1 (en) | 2011-06-23 |
EP2513117A1 (en) | 2012-10-24 |
CO6541615A2 (es) | 2012-10-16 |
AU2010332811A1 (en) | 2012-06-21 |
CL2012001601A1 (es) | 2012-10-05 |
IL220360A (en) | 2015-03-31 |
ZA201204433B (en) | 2014-11-26 |
EA019980B1 (ru) | 2014-07-30 |
WO2011073339A1 (en) | 2011-06-23 |
US9040707B2 (en) | 2015-05-26 |
KR20120097400A (ko) | 2012-09-03 |
AR079509A1 (es) | 2012-02-01 |
AU2010332811B2 (en) | 2014-07-24 |
NZ600605A (en) | 2013-08-30 |
CN102666552B (zh) | 2014-11-26 |
EP2513117B1 (en) | 2013-08-28 |
ES2431302T3 (es) | 2013-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112015031903A2 (pt) | composto, sal farmaceuticamente aceitável do composto, composição farmacêutica e utilização de um composto | |
BR112015022566A2 (pt) | composto e composição farmacêutica | |
MX2011005242A (es) | Derivados de indol y benzoxazina como moduladores de los receptores de glutamato metabotropicos. | |
BR112015016315A2 (pt) | fluoro-[1,3]oxazinas como inibidores de bace1 | |
BR112012020273A2 (pt) | Compostos de pirazolopiridina, pirazolopirazina, pirazolopirimidina, pirazolotiofeno e pirazolotiazol como pontencializadores alostéricos de mglur4, composições e métodos de tratamento de disfunção neurológica | |
BRPI1009381B8 (pt) | compostos, composição farmacêutica e uso de compostos e de composição farmacêutica | |
CL2012001072A1 (es) | Compuestos derivados de feniletinilo, moduladores alostericos positivos del receptor de glutamato (mglur5); procedimiento de preparacion; composicion farmaceutica; y uso para tratar esquizofrenia o enfermedades cognitivas. | |
EA201071169A1 (ru) | ГИДРОКСИМЕТИЛПИРРОЛИДИНЫ В КАЧЕСТВЕ АГОНИСТОВ АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ β3 | |
BR112012013431A8 (pt) | composto, composição farmacêutica e seu uso | |
BR112012018386A2 (pt) | "inibidores isoindolinona de fosfatidilinositol 3-quinase" | |
BR112012020271A2 (pt) | Benzisoxazóis e azabenzisoxazóis como potencializadores alostéricos de mglur4 composições e métodos de tratamentos de disfunção neurológica | |
MA32369B1 (fr) | Composes de benzene sulfonamide thiazole et oxazole | |
BRPI0817242A8 (pt) | compostos derivados de 1,1,1-trifluoro-2-hidroxi-3-fenilpropano, processo para a sua manufatura e composições farmacêuticas que os contêm | |
BRPI0919876A8 (pt) | Composto, composição farmacêutica, uso de um composto, e, método para intensificar a qualidade do sono, para tratar insônia, e para tratar ou controlar obesidade em um paciente mamífero que necessita do mesmo. | |
UA111579C2 (uk) | ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ | |
ATE478072T1 (de) | Spiroimidazol-derivate als ppar-modulatoren | |
BR112013031098A2 (pt) | halogeno-alquil-1,3 oxazinas como inibidores de bace1 e/ou bace2 | |
EA201390947A1 (ru) | Соединения 2-амино-4-арилтиазола в качестве антагонистов trpa1 | |
BRPI0718714B8 (pt) | arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende | |
BR112014012056A8 (pt) | compostos farmacêuticos | |
UY30572A1 (es) | N-(1-ftalazin-1-il-piperidin-4-il)-amidas como moduladores del receptor ep2 | |
BR112014006763A2 (pt) | n-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexa-hidro-ciclopenta[e][1,3]oxazin-4-il)-fenil)-amidas como inibidores de bace1 | |
BRPI0821266B8 (pt) | Derivados de arilamida triazol-substituída e seu uso e composição farmacêutica | |
BR112021006319A2 (pt) | compostos de indolinona para uso como inibidores de map4k1 | |
ATE542795T1 (de) | Benzylpiperazinderivate als motilin- rezeptorantagonisten |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |