DE602005006101D1 - Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien - Google Patents

Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien

Info

Publication number
DE602005006101D1
DE602005006101D1 DE602005006101T DE602005006101T DE602005006101D1 DE 602005006101 D1 DE602005006101 D1 DE 602005006101D1 DE 602005006101 T DE602005006101 T DE 602005006101T DE 602005006101 T DE602005006101 T DE 602005006101T DE 602005006101 D1 DE602005006101 D1 DE 602005006101D1
Authority
DE
Germany
Prior art keywords
chinolines
mycobacteria
inhibitors
substituted
substituted chinolines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005006101T
Other languages
English (en)
Other versions
DE602005006101T2 (de
Inventor
Jerome Emile George Guillemont
Elisabeth T J Pasquier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602005006101D1 publication Critical patent/DE602005006101D1/de
Application granted granted Critical
Publication of DE602005006101T2 publication Critical patent/DE602005006101T2/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE602005006101T 2004-01-23 2005-01-21 Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien Active DE602005006101T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53876804P 2004-01-23 2004-01-23
US538768P 2004-01-23
PCT/EP2005/050267 WO2005070924A1 (en) 2004-01-23 2005-01-21 Substituted quinolines and their use as mycobacterial inhibitors

Publications (2)

Publication Number Publication Date
DE602005006101D1 true DE602005006101D1 (de) 2008-05-29
DE602005006101T2 DE602005006101T2 (de) 2009-07-02

Family

ID=34807224

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005006101T Active DE602005006101T2 (de) 2004-01-23 2005-01-21 Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien

Country Status (20)

Country Link
US (1) US7338949B2 (de)
EP (1) EP1711492B1 (de)
JP (1) JP4773975B2 (de)
KR (1) KR101150172B1 (de)
CN (1) CN1910177B (de)
AP (1) AP2188A (de)
AT (1) ATE392423T1 (de)
AU (1) AU2005206330B2 (de)
BR (1) BRPI0507076B8 (de)
CA (1) CA2553266C (de)
DE (1) DE602005006101T2 (de)
EA (1) EA011359B1 (de)
ES (1) ES2306082T3 (de)
HK (1) HK1100927A1 (de)
IL (1) IL177013A0 (de)
NO (1) NO337705B1 (de)
NZ (1) NZ547277A (de)
UA (1) UA85570C2 (de)
WO (1) WO2005070924A1 (de)
ZA (1) ZA200606070B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075428A1 (en) * 2004-01-29 2005-08-18 Janssen Pharmaceutica N.V. Quinoline derivatives for use as mycobacterial inhibitors
EE05697B1 (et) * 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
JO2855B1 (en) 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents
WO2007022946A1 (de) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Heterocyclische verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JO2685B1 (en) 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
WO2009091324A1 (en) * 2008-01-14 2009-07-23 Jyoti Chattopadhyaya Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents
MX355050B (es) * 2012-04-27 2018-04-02 Janssen Pharmaceutica Nv Derivados de quinolina antibacterianos.
CN104254528B (zh) * 2012-04-27 2017-06-06 詹森药业有限公司 抗菌的喹啉衍生物
AU2016255724B2 (en) * 2015-04-29 2020-05-14 The State of Israel, Ministry of Agriculture and Rural Development Agricultural Research Organization (ARO) (Volcani Center) Anti-phytopathogenic compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0936866A4 (de) * 1996-10-28 2001-04-11 Dept Of The Army Us Government Verbindungen, zusammensetzungen und methoden zur behandlung von antibiotika-resisten infektionen
DE69807222T2 (de) * 1997-06-02 2003-04-17 Janssen Pharmaceutica N.V., Beerse (imidazol-5-yl)methyl-2-quinolinone derivativen als inhibitoren von proliferation der glatten muskelzellen
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
KR20010014030A (ko) * 1997-06-19 2001-02-26 더글라스이.리디치 퀴놀린-인돌 항균제, 이들의 용도 및 조성물
US6838467B2 (en) * 2000-02-24 2005-01-04 Janssen Pharmaceutica N. V. Dosing regimen
BR0114253A (pt) * 2000-10-02 2003-07-01 Janssen Pharmaceutica Nv Antagonistas de receptor de glutamato metabotrópico
JP4484703B2 (ja) * 2002-07-25 2010-06-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キノリン誘導体およびミコバクテリア抑制剤としてのそれらの使用

Also Published As

Publication number Publication date
HK1100927A1 (en) 2007-10-05
BRPI0507076A (pt) 2007-06-19
AU2005206330B2 (en) 2010-09-16
NZ547277A (en) 2009-08-28
EP1711492B1 (de) 2008-04-16
KR20060127016A (ko) 2006-12-11
EA200601363A1 (ru) 2006-12-29
WO2005070924A1 (en) 2005-08-04
CN1910177A (zh) 2007-02-07
NO337705B1 (no) 2016-06-06
ES2306082T3 (es) 2008-11-01
NO20063747L (no) 2006-08-22
WO2005070924A8 (en) 2006-05-11
CA2553266A1 (en) 2005-08-04
AU2005206330A1 (en) 2005-08-04
BRPI0507076B1 (pt) 2019-06-25
JP4773975B2 (ja) 2011-09-14
JP2007518775A (ja) 2007-07-12
US7338949B2 (en) 2008-03-04
AP2006003693A0 (en) 2006-08-31
ATE392423T1 (de) 2008-05-15
CN1910177B (zh) 2010-05-05
BRPI0507076B8 (pt) 2021-05-25
UA85570C2 (uk) 2009-02-10
CA2553266C (en) 2013-03-12
EA011359B1 (ru) 2009-02-27
EP1711492A1 (de) 2006-10-18
ZA200606070B (en) 2007-12-27
US20070082895A1 (en) 2007-04-12
IL177013A0 (en) 2006-12-10
KR101150172B1 (ko) 2012-05-25
DE602005006101T2 (de) 2009-07-02
AP2188A (en) 2010-12-14

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