EA200601363A1 - Замещённые хинолины и их применение в качестве микобактериальных ингибиторов - Google Patents
Замещённые хинолины и их применение в качестве микобактериальных ингибиторовInfo
- Publication number
- EA200601363A1 EA200601363A1 EA200601363A EA200601363A EA200601363A1 EA 200601363 A1 EA200601363 A1 EA 200601363A1 EA 200601363 A EA200601363 A EA 200601363A EA 200601363 A EA200601363 A EA 200601363A EA 200601363 A1 EA200601363 A1 EA 200601363A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen
- het
- alkyloxy
- alkylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Настоящее изобретение относится к новым замещенным производным хинолина общей формулы (Ia) или (Ib), их четвертичным аминам, стереохимически изомерным формам, таутомерным формам и их N-оксидным формам, где Rпредставляет собой водород, галоген, галогеналкил, циано, гидрокси, Ar, Het, алкил, алкилокси, алкилтио, алкилоксиалкил, алкилтиоалкил, Ar-алкил или ди(Ar) алкил; р равно 1, 2, 3 или 4; Rпредставляет собой водород, гидрокси, тио, алкилокси, алкилоксиалкилокси, алкилтио, моно или ди(алкил)амино или радикал формулы (Ic); Rпредставляет собой алкил, Ar, Ar-алкил, Het или Het-алкил; Rпредставляет собой водород, алкил или бензил; Rпредставляет собой водород, галоген, галогеналкил, гидрокси, Ar, алкил, алкилокси, алкилтио, алкилоксиалкил, алкилтиоалкил, Ar-алкил или ди(Ar)алкил; или два вицинальных радикала Rмогут вместе с фенильным кольцом, с которым они связаны, образовывать нафтил; r равно 1, 2, 3, 4 или 5; Rпредставляет собой водород, алкил, Ar или Het; Rпредставляет собой водород или алкил; Rпредставляет собой оксо; или Rи Rвместе образуют радикал -CH=CH-N=; Z представляет собой СНили С(=O). Заявленные соединения применимы для лечения микобактериальных заболеваний, в частности заболеваний, вызванных патогенной микобактерией, такой как М. tuberculosis, M. bovis, M. avium, M. smegmatis и М. marinum. Кроме того, заявлена фармацевтическая композиция, содержащая соединение настоящего изобретения, применение заявленных соединений или композиций для получения лекарственного средства для лечения микобактериальных заболеваний и способ получения заявленных соединений.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53876804P | 2004-01-23 | 2004-01-23 | |
| PCT/EP2005/050267 WO2005070924A1 (en) | 2004-01-23 | 2005-01-21 | Substituted quinolines and their use as mycobacterial inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200601363A1 true EA200601363A1 (ru) | 2006-12-29 |
| EA011359B1 EA011359B1 (ru) | 2009-02-27 |
Family
ID=34807224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200601363A EA011359B1 (ru) | 2004-01-23 | 2005-01-21 | Замещенные хинолины и их применение в качестве микобактериальных ингибиторов |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7338949B2 (ru) |
| EP (1) | EP1711492B1 (ru) |
| JP (1) | JP4773975B2 (ru) |
| KR (1) | KR101150172B1 (ru) |
| CN (1) | CN1910177B (ru) |
| AP (1) | AP2188A (ru) |
| AT (1) | ATE392423T1 (ru) |
| AU (1) | AU2005206330B2 (ru) |
| BR (1) | BRPI0507076B8 (ru) |
| CA (1) | CA2553266C (ru) |
| DE (1) | DE602005006101T2 (ru) |
| EA (1) | EA011359B1 (ru) |
| ES (1) | ES2306082T3 (ru) |
| HK (1) | HK1100927A1 (ru) |
| IL (1) | IL177013A0 (ru) |
| NO (1) | NO337705B1 (ru) |
| NZ (1) | NZ547277A (ru) |
| UA (1) | UA85570C2 (ru) |
| WO (1) | WO2005070924A1 (ru) |
| ZA (1) | ZA200606070B (ru) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1713776B1 (en) * | 2004-01-29 | 2008-05-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives for use as mycobacterial inhibitors |
| EE05697B1 (et) | 2005-06-08 | 2014-02-17 | Janssen Pharmaceutica N.V. | Kinoliini derivaadid kui antibakteriaalsed toimeained |
| JO2855B1 (en) | 2005-08-03 | 2015-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| JO2837B1 (en) * | 2005-08-03 | 2014-09-15 | جانسن فارمسيتكا ان في | Quinoline derivatives acting as antibacterial agents |
| US8686002B2 (en) | 2005-08-21 | 2014-04-01 | AbbVie Deutschland GmbH & Co. KG | Heterocyclic compounds and their use as binding partners for 5-HT5 receptors |
| JO3271B1 (ar) | 2006-12-06 | 2018-09-16 | Janssen Pharmaceutica Nv | مشتقات الكوينولين المضادة للجراثيم |
| JO2970B1 (en) | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2684B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| JO2685B1 (en) | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان في | Quinoline antibacterial derivatives |
| CA2711912A1 (en) * | 2008-01-14 | 2009-07-23 | Jyoti Chattopadhyaya | Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents |
| ES2576491T3 (es) * | 2012-04-27 | 2016-07-07 | Janssen Pharmaceutica, N.V. | Derivados de quinolina antibacterianos |
| MX358506B (es) * | 2012-04-27 | 2018-08-22 | Janssen Pharmaceutica Nv | Derivados de quinolina antibacterianos. |
| AU2016255724B2 (en) * | 2015-04-29 | 2020-05-14 | The State of Israel, Ministry of Agriculture and Rural Development Agricultural Research Organization (ARO) (Volcani Center) | Anti-phytopathogenic compositions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001503411A (ja) * | 1996-10-28 | 2001-03-13 | ディパートメント オブ ジ アーミー，ユー．エス．ガバメント | 抗生物質耐性感染症の処置のための化合物、組成物および方法 |
| JP4209472B2 (ja) * | 1997-06-02 | 2009-01-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 平滑筋細胞増殖のインヒビターとしての（イミダゾール−５−イル）メチル−２−キノリノン誘導体 |
| US6103905A (en) * | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| JP2002505689A (ja) * | 1997-06-19 | 2002-02-19 | セプレイコー インコーポレイテッド | キノリン−インドール抗菌剤、それらに関する用途及び組成物 |
| WO2001062234A2 (en) * | 2000-02-24 | 2001-08-30 | Janssen Pharmaceutica N.V. | Dosing regimen |
| DE60134762D1 (de) * | 2000-10-02 | 2008-08-21 | Janssen Pharmaceutica Nv | Metabotropische glutamatrezeptor-antagonisten |
| DK2301544T3 (da) | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
-
2005
- 2005-01-21 NZ NZ547277A patent/NZ547277A/xx not_active IP Right Cessation
- 2005-01-21 EP EP05701586A patent/EP1711492B1/en active Active
- 2005-01-21 AP AP2006003693A patent/AP2188A/xx active
- 2005-01-21 ES ES05701586T patent/ES2306082T3/es active Active
- 2005-01-21 US US10/596,386 patent/US7338949B2/en active Active
- 2005-01-21 AT AT05701586T patent/ATE392423T1/de active
- 2005-01-21 KR KR1020067013237A patent/KR101150172B1/ko active IP Right Grant
- 2005-01-21 EA EA200601363A patent/EA011359B1/ru not_active IP Right Cessation
- 2005-01-21 CN CN2005800026797A patent/CN1910177B/zh not_active Expired - Fee Related
- 2005-01-21 CA CA2553266A patent/CA2553266C/en not_active Expired - Fee Related
- 2005-01-21 AU AU2005206330A patent/AU2005206330B2/en not_active Ceased
- 2005-01-21 WO PCT/EP2005/050267 patent/WO2005070924A1/en active IP Right Grant
- 2005-01-21 DE DE602005006101T patent/DE602005006101T2/de active Active
- 2005-01-21 UA UAA200605780A patent/UA85570C2/ru unknown
- 2005-01-21 JP JP2006550174A patent/JP4773975B2/ja not_active Expired - Fee Related
- 2005-01-21 BR BRPI0507076A patent/BRPI0507076B8/pt not_active IP Right Cessation
-
2006
- 2006-07-20 IL IL177013A patent/IL177013A0/en active IP Right Grant
- 2006-07-21 ZA ZA200606070A patent/ZA200606070B/xx unknown
- 2006-08-22 NO NO20063747A patent/NO337705B1/no not_active IP Right Cessation
-
2007
- 2007-06-06 HK HK07106003.5A patent/HK1100927A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060127016A (ko) | 2006-12-11 |
| BRPI0507076B1 (pt) | 2019-06-25 |
| UA85570C2 (ru) | 2009-02-10 |
| NZ547277A (en) | 2009-08-28 |
| KR101150172B1 (ko) | 2012-05-25 |
| DE602005006101D1 (de) | 2008-05-29 |
| JP4773975B2 (ja) | 2011-09-14 |
| NO337705B1 (no) | 2016-06-06 |
| ZA200606070B (en) | 2007-12-27 |
| US20070082895A1 (en) | 2007-04-12 |
| NO20063747L (no) | 2006-08-22 |
| EP1711492A1 (en) | 2006-10-18 |
| AP2188A (en) | 2010-12-14 |
| HK1100927A1 (en) | 2007-10-05 |
| BRPI0507076A (pt) | 2007-06-19 |
| AP2006003693A0 (en) | 2006-08-31 |
| IL177013A0 (en) | 2006-12-10 |
| CA2553266C (en) | 2013-03-12 |
| WO2005070924A1 (en) | 2005-08-04 |
| CA2553266A1 (en) | 2005-08-04 |
| EP1711492B1 (en) | 2008-04-16 |
| CN1910177A (zh) | 2007-02-07 |
| ES2306082T3 (es) | 2008-11-01 |
| WO2005070924A8 (en) | 2006-05-11 |
| DE602005006101T2 (de) | 2009-07-02 |
| CN1910177B (zh) | 2010-05-05 |
| ATE392423T1 (de) | 2008-05-15 |
| JP2007518775A (ja) | 2007-07-12 |
| EA011359B1 (ru) | 2009-02-27 |
| AU2005206330A1 (en) | 2005-08-04 |
| AU2005206330B2 (en) | 2010-09-16 |
| BRPI0507076B8 (pt) | 2021-05-25 |
| US7338949B2 (en) | 2008-03-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |