DE602005006744D1 - Chinolinderivate zur verwendung als inhibitoren von mycobakterien - Google Patents

Chinolinderivate zur verwendung als inhibitoren von mycobakterien

Info

Publication number
DE602005006744D1
DE602005006744D1 DE602005006744T DE602005006744T DE602005006744D1 DE 602005006744 D1 DE602005006744 D1 DE 602005006744D1 DE 602005006744 T DE602005006744 T DE 602005006744T DE 602005006744 T DE602005006744 T DE 602005006744T DE 602005006744 D1 DE602005006744 D1 DE 602005006744D1
Authority
DE
Germany
Prior art keywords
mycobacteria
inhibitors
chinoline derivatives
chinoline
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005006744T
Other languages
English (en)
Inventor
Jerome Emile George Guillemont
Elisabeth Therese Jea Pasquier
David Francis Alain Lancois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE602005006744D1 publication Critical patent/DE602005006744D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE602005006744T 2004-01-29 2005-01-28 Chinolinderivate zur verwendung als inhibitoren von mycobakterien Active DE602005006744D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04075286 2004-01-29
PCT/EP2005/050375 WO2005075428A1 (en) 2004-01-29 2005-01-28 Quinoline derivatives for use as mycobacterial inhibitors

Publications (1)

Publication Number Publication Date
DE602005006744D1 true DE602005006744D1 (de) 2008-06-26

Family

ID=34833674

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005006744T Active DE602005006744D1 (de) 2004-01-29 2005-01-28 Chinolinderivate zur verwendung als inhibitoren von mycobakterien

Country Status (21)

Country Link
US (1) US7790894B2 (de)
EP (1) EP1713776B1 (de)
JP (1) JP4919810B2 (de)
KR (1) KR101160183B1 (de)
CN (1) CN1910154B (de)
AP (1) AP2321A (de)
AT (1) ATE395336T1 (de)
AU (1) AU2005210036B2 (de)
BR (1) BRPI0507312A (de)
CA (1) CA2554049C (de)
DE (1) DE602005006744D1 (de)
EA (1) EA011572B9 (de)
ES (1) ES2306098T3 (de)
HK (1) HK1099297A1 (de)
IL (1) IL177101A (de)
MX (1) MXPA06008596A (de)
NO (1) NO337253B1 (de)
NZ (1) NZ547614A (de)
UA (1) UA83875C2 (de)
WO (1) WO2005075428A1 (de)
ZA (1) ZA200606291B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO3271B1 (ar) 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
US8741917B2 (en) 2009-01-15 2014-06-03 Rutgers, The State University Of New Jersey Benzo [C] phenanthridines as antimicrobial agents
WO2010127307A1 (en) 2009-04-30 2010-11-04 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2810162A1 (en) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2803890A1 (en) 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Antimicrobial agents
RU2486175C2 (ru) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
US9822108B2 (en) 2012-01-13 2017-11-21 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2868002C (en) 2012-03-21 2021-07-13 Rutgers, The State University Of New Jersey Antimicrobial agents
DK2841425T3 (en) 2012-04-27 2016-06-27 Janssen Pharmaceutica Nv ANTIBACTERIAL QUINOLIN DERIVATIVES
WO2013160431A1 (en) 2012-04-27 2013-10-31 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
BR112015008308A2 (pt) 2012-10-16 2017-12-05 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por metileno do ror-gama-t
KR20150070348A (ko) 2012-10-16 2015-06-24 얀센 파마슈티카 엔.브이. RoRγt의 헤테로아릴 결합 퀴놀리닐 조절제
SG11201502935VA (en) 2012-10-16 2015-09-29 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of ror-gamma-t
KR20160068956A (ko) 2013-10-15 2016-06-15 얀센 파마슈티카 엔.브이. RORyT의 퀴놀리닐 조절제
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
JP6423423B2 (ja) 2013-10-15 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｒｏｒγｔのアルキル結合キノリニルモジュレーター
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
CA3015768A1 (en) 2016-02-25 2017-08-31 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
WO2018183917A1 (en) 2017-03-30 2018-10-04 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0936866A4 (de) * 1996-10-28 2001-04-11 Dept Of The Army Us Government Verbindungen, zusammensetzungen und methoden zur behandlung von antibiotika-resisten infektionen
EP0991623A2 (de) * 1997-06-19 2000-04-12 Sepracor, Inc. Chinolin-indol verbindungen mit antimikrobieller wirkung
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU2717899A (en) * 1998-01-26 1999-08-09 Smithkline Beecham Plc Quinoline derivatives as antibacterials
SI2301544T1 (sl) * 2002-07-25 2013-01-31 Janssen Pharmaceutica, N.V. Derivati kinolina kot vmesne spojine za mikobakterijske inhibitorje
EP1711492B1 (de) * 2004-01-23 2008-04-16 Janssen Pharmaceutica N.V. Substituierte chinoline und deren verwendung als inhibitoren von mycobakterien

Also Published As

Publication number Publication date
ZA200606291B (en) 2008-02-27
AP2006003705A0 (en) 2006-08-31
AU2005210036A1 (en) 2005-08-18
NO337253B1 (no) 2016-02-22
KR20070004597A (ko) 2007-01-09
CN1910154B (zh) 2011-08-17
JP2007519687A (ja) 2007-07-19
IL177101A (en) 2012-01-31
CA2554049C (en) 2012-12-18
CN1910154A (zh) 2007-02-07
EP1713776B1 (de) 2008-05-14
EA200601391A1 (ru) 2006-12-29
KR101160183B1 (ko) 2012-06-26
NZ547614A (en) 2009-04-30
IL177101A0 (en) 2006-12-10
MXPA06008596A (es) 2006-08-28
HK1099297A1 (en) 2007-08-10
EA011572B1 (ru) 2009-04-28
JP4919810B2 (ja) 2012-04-18
EA011572B9 (ru) 2018-01-31
ES2306098T3 (es) 2008-11-01
CA2554049A1 (en) 2005-08-18
AU2005210036B2 (en) 2010-12-23
AP2321A (en) 2011-11-16
US20070299106A1 (en) 2007-12-27
UA83875C2 (ru) 2008-08-26
ATE395336T1 (de) 2008-05-15
NO20063821L (no) 2006-08-28
WO2005075428A1 (en) 2005-08-18
US7790894B2 (en) 2010-09-07
EP1713776A1 (de) 2006-10-25
BRPI0507312A (pt) 2007-06-26

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