ATE468338T1 - Pyrrolochinolinderivate und ihre verwendung als proteinkinasehemmer - Google Patents

Pyrrolochinolinderivate und ihre verwendung als proteinkinasehemmer

Info

Publication number
ATE468338T1
ATE468338T1 AT06777531T AT06777531T ATE468338T1 AT E468338 T1 ATE468338 T1 AT E468338T1 AT 06777531 T AT06777531 T AT 06777531T AT 06777531 T AT06777531 T AT 06777531T AT E468338 T1 ATE468338 T1 AT E468338T1
Authority
AT
Austria
Prior art keywords
pyrrolochinoline
derivatives
protein kinase
kinase inhibitors
inhibitors
Prior art date
Application number
AT06777531T
Other languages
English (en)
Inventor
Antoine Dumoulin
El Bachir Kaloun
Stephane Poigny
Hugues Bienhayme
Serge Grisoni
Remi Rabot
Rachid Rahali
Eric Tam
Pascaline Klein
Karim Bedjeguelal
Houcine Rahali
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Application granted granted Critical
Publication of ATE468338T1 publication Critical patent/ATE468338T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT06777531T 2005-07-01 2006-06-30 Pyrrolochinolinderivate und ihre verwendung als proteinkinasehemmer ATE468338T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0507009A FR2887881B1 (fr) 2005-07-01 2005-07-01 Inhibiteurs de proteines kinases
PCT/EP2006/063768 WO2007003611A1 (fr) 2005-07-01 2006-06-30 Derives de pyrroloquinolines et leur utilisation comme inhibiteurs de proteines kinases

Publications (1)

Publication Number Publication Date
ATE468338T1 true ATE468338T1 (de) 2010-06-15

Family

ID=36090819

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06777531T ATE468338T1 (de) 2005-07-01 2006-06-30 Pyrrolochinolinderivate und ihre verwendung als proteinkinasehemmer

Country Status (11)

Country Link
US (1) US8426437B2 (de)
EP (1) EP1899335B1 (de)
JP (1) JP5208735B2 (de)
AR (1) AR054813A1 (de)
AT (1) ATE468338T1 (de)
CA (1) CA2613211A1 (de)
DE (1) DE602006014405D1 (de)
ES (1) ES2346564T3 (de)
FR (1) FR2887881B1 (de)
TW (1) TWI393719B (de)
WO (1) WO2007003611A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117791A2 (en) 2006-03-31 2007-10-18 Wellstat Therapeutics Corporation Combination treatment of metabolic disorders
AU2007285827A1 (en) 2006-08-17 2008-02-21 Wellstat Therapeutics Corporation Combination treatment for metabolic disorders
WO2008104475A1 (en) * 2007-02-27 2008-09-04 Nerviano Medical Sciences S.R.L. Isoquinolinopyrrolopyridinones active as kinase inhibitors
CA2797694A1 (en) 2010-04-29 2011-11-03 The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services Activators of human pyruvate kinase
AU2015101598A4 (en) * 2015-09-17 2015-12-03 Macau University Of Science And Technology Novel ros1 inhibitor and its use
MX2018013885A (es) 2016-05-13 2019-08-16 Inst De Medicina Molecular Joaeo Lobo Antunes Métodos de tratamiento de enfermedades asociadas con células linfoides innatas del grupo 3 (cli3).
JP7732668B2 (ja) * 2019-08-05 2025-09-02 北京志健金瑞生物医▲薬▼科技有限公司 窒素含有多環式縮合環系化合物、その薬学的組成物、製造方法及び用途
TWI818424B (zh) * 2021-02-08 2023-10-11 大陸商北京志健金瑞生物醫藥科技有限公司 含氮多環稠環類化合物，其藥物組合物、製備方法和用途
JP2024522938A (ja) 2021-06-03 2024-06-21 フンダサン デー．アンナ ジ ソーメル チャンパリマウド エー ドクトル カルロス モンテス チャンパリマウド 脳－脂肪回路を介してｉｌｃ２および肥満度を制御する神経－間葉単位
JP2025532945A (ja) * 2022-09-28 2025-10-03 ソルブ セラピューティクス，インク． 組成物およびその使用
US11884668B1 (en) 2023-08-02 2024-01-30 King Faisal University Substituted pyrido[3′,4′:4,5]pyrrolo[2,3-c]quinolines as CK2 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205437A1 (es) * 1972-09-25 1976-05-07 Hoffmann La Roche Procedimiento para la preparacion de derivados de indoloquinolinona
FR2636063B1 (fr) * 1988-09-05 1993-04-30 Centre Nat Rech Scient Composes phenylpyrroliques utiles en tant que medicaments, leur preparation et leur application
US6335342B1 (en) * 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
AU2002361577A1 (en) * 2001-10-30 2003-05-12 Merck And Co., Inc. Tyrosine kinase inhibitors
KR20040111445A (ko) * 2002-03-28 2004-12-31 에자이 가부시키가이샤 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌
JPWO2006112331A1 (ja) * 2005-04-13 2008-12-11 大日本住友製薬株式会社 新規縮合ピロール誘導体

Also Published As

Publication number Publication date
FR2887881A1 (fr) 2007-01-05
JP5208735B2 (ja) 2013-06-12
AR054813A1 (es) 2007-07-18
JP2008545001A (ja) 2008-12-11
US20090042876A1 (en) 2009-02-12
TW200740808A (en) 2007-11-01
WO2007003611A1 (fr) 2007-01-11
DE602006014405D1 (de) 2010-07-01
EP1899335B1 (de) 2010-05-19
FR2887881B1 (fr) 2009-10-09
ES2346564T3 (es) 2010-10-18
EP1899335A1 (de) 2008-03-19
TWI393719B (zh) 2013-04-21
CA2613211A1 (fr) 2007-01-11
US8426437B2 (en) 2013-04-23

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties