UA83549C2 - Тетрагідрохінолінони та їх застосування як антагоністів метаботропних глутаматних рецепторів - Google Patents
Тетрагідрохінолінони та їх застосування як антагоністів метаботропних глутаматних рецепторів Download PDFInfo
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- UA83549C2 UA83549C2 UAA200610294A UAA200610294A UA83549C2 UA 83549 C2 UA83549 C2 UA 83549C2 UA A200610294 A UAA200610294 A UA A200610294A UA A200610294 A UAA200610294 A UA A200610294A UA 83549 C2 UA83549 C2 UA 83549C2
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- Prior art keywords
- aai
- bzitezi
- aeiabev
- aeazavi
- abev
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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- C07—ORGANIC CHEMISTRY
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- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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- C07D221/04—Ortho- or peri-condensed ring systems
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- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54878804P | 2004-02-27 | 2004-02-27 | |
| PCT/GB2005/000717 WO2005082856A2 (en) | 2004-02-27 | 2005-02-25 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA83549C2 true UA83549C2 (uk) | 2008-07-25 |
Family
ID=34911013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200610294A UA83549C2 (uk) | 2004-02-27 | 2005-02-25 | Тетрагідрохінолінони та їх застосування як антагоністів метаботропних глутаматних рецепторів |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7598384B2 (https=) |
| EP (1) | EP1723116B1 (https=) |
| JP (1) | JP4712027B2 (https=) |
| KR (1) | KR100846347B1 (https=) |
| CN (1) | CN1922146A (https=) |
| AR (1) | AR049006A1 (https=) |
| AT (1) | ATE409182T1 (https=) |
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| BR (1) | BRPI0508225A (https=) |
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| EA (1) | EA010656B1 (https=) |
| ES (1) | ES2315853T3 (https=) |
| IL (1) | IL177524A (https=) |
| PL (1) | PL1723116T3 (https=) |
| PT (1) | PT1723116E (https=) |
| SI (1) | SI1723116T1 (https=) |
| TW (1) | TWI301760B (https=) |
| UA (1) | UA83549C2 (https=) |
| UY (1) | UY28775A1 (https=) |
| WO (1) | WO2005082856A2 (https=) |
| ZA (1) | ZA200606686B (https=) |
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| WO2007023242A1 (en) * | 2005-08-24 | 2007-03-01 | Merz Pharma Gmbh & Co. Kgaa | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors |
| EP1943247A1 (en) * | 2005-08-25 | 2008-07-16 | Merz Pharma GmbH & Co.KGaA | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| AU2006303037A1 (en) * | 2005-10-21 | 2007-04-26 | Merz Pharma Gmbh & Co Kgaa | Chromenones and their use as modulators of metabotropic glutamate receptors |
| AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
| TW200732313A (en) * | 2005-12-15 | 2007-09-01 | Astrazeneca Ab | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | 5ht受容体介在性の神経新生 |
| EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| KR101450356B1 (ko) | 2006-11-24 | 2014-10-15 | 에이씨 이뮨 에스.에이. | 알츠하이머와 같은 아밀로이드 또는 아밀로이드-유사 단백질과 관련된 질환의 치료를 위한 n-(메틸)-1h-피라졸-3-아민, n-(메틸)-피리딘-2-아민 및 n-(메틸)-티아졸-2-아민 유도체 |
| MX2011004680A (es) * | 2008-11-06 | 2011-05-25 | Astrazeneca Ab | Moduladores de beta amiloide. |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| EP2311823A1 (en) * | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases |
| CN102666551B (zh) | 2009-12-18 | 2014-12-10 | 詹森药业有限公司 | 作为mglur5受体的变构调节剂的双环噻唑 |
| WO2011073339A1 (en) | 2009-12-18 | 2011-06-23 | Janssen Pharmaceutica Nv | Bicyclic thiazoles as allosteric modulators of mglur5 receptors |
| GB0922589D0 (en) * | 2009-12-23 | 2010-02-10 | Almac Discovery Ltd | Pharmaceutical compounds |
| AR083475A1 (es) | 2010-10-18 | 2013-02-27 | Merz Pharma Gmbh & Co Kgaa | Moduladores de receptores de glutamato metabotropicos |
| KR20130129975A (ko) * | 2010-11-16 | 2013-11-29 | 지이 헬쓰케어 리미티드 | 타우 병리의 영상화 프로브로서의 헤테로시클릭 화합물 |
| WO2012139876A1 (en) | 2011-04-14 | 2012-10-18 | Merz Pharma Gmbh & Co. Kgaa | Enteric formulations of metabotropic glutamate receptor modulators |
| EP2891656A4 (en) * | 2012-08-30 | 2016-03-02 | Nippon Shinyaku Co Ltd | PYRIDINE DERIVATIVE AND MEDICAMENT THEREFOR |
| EP2951157A1 (en) * | 2013-02-04 | 2015-12-09 | Merck Patent GmbH | Positive allosteric modulators of mglur3 |
| CN104513200B (zh) * | 2013-09-26 | 2017-05-03 | 江苏苏中药业集团股份有限公司 | 取代丁烯酰胺的马来酸盐及其晶型 |
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
| SI3294713T1 (sl) | 2015-05-15 | 2021-08-31 | Aurigene Discovery Technologies Limited, | Nadomeščene spojine tetrahidrokinolinona kot ROR gama modulatorji |
| US10112955B2 (en) * | 2015-10-29 | 2018-10-30 | Effector Therapeutics, Inc. | Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2 |
| WO2017087808A1 (en) | 2015-11-20 | 2017-05-26 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers |
| US20200123127A1 (en) * | 2016-04-25 | 2020-04-23 | Everon Biosciences, Inc. | Removal of senescence-associated macrophages |
| CA3053493A1 (en) | 2017-02-14 | 2018-08-23 | Effector Therapeutics, Inc. | Piperidine-substituted mnk inhibitors and methods related thereto |
| CN113286592A (zh) | 2018-10-24 | 2021-08-20 | 效应治疗股份有限公司 | Mnk抑制剂的结晶形式 |
| GB2600384A (en) | 2020-09-30 | 2022-05-04 | Vaderis Therapeutics Ag | Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia |
| WO2023250480A1 (en) * | 2022-06-23 | 2023-12-28 | The Cleveland Clinic Foundation | 3-βHSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3501479A (en) * | 1967-05-19 | 1970-03-17 | American Cyanamid Co | Dihydroquinolines and substituted dihydroquinolines and method of preparing the same |
| DE2001572A1 (de) | 1970-01-15 | 1971-07-22 | Agfa Gevaert Ag | Spektral sensibilisiertes lichtempfindliches Material |
| DE2449030A1 (de) | 1974-10-11 | 1976-05-20 | Schering Ag | Neue pyridin-derivate |
| WO1988002251A1 (en) | 1986-09-26 | 1988-04-07 | Ici Australia Operations Proprietary Limited | Sunscreen compositions and compounds for use therein |
| US5110815A (en) * | 1990-12-03 | 1992-05-05 | Hoechst-Roussel Pharmaceuticals Inc. | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use |
| US5216164A (en) * | 1990-12-03 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds |
| AU4481899A (en) * | 1998-02-20 | 1999-09-06 | Takeda Chemical Industries Ltd. | Aminoguanidine hydrazone derivatives, process for producing the same and drugs thereof |
| GB0003632D0 (en) * | 2000-02-16 | 2000-04-05 | Univ Hong Kong Science & Techn | Dimeric compounds |
| CZ20031145A3 (cs) | 2000-10-02 | 2003-12-17 | Janssen Pharmaceutica N.V. | Antagonisté metabotropního glutamátového receptoru |
| CA2479109C (en) * | 2002-03-29 | 2011-08-02 | Janssen Pharmaceutica N.V. | Radiolabelled quinoline and quinolinone derivatives and their use as metabotropic glutamate receptor ligands |
-
2005
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- 2005-02-25 CN CNA2005800060497A patent/CN1922146A/zh active Pending
- 2005-02-25 PL PL05717798T patent/PL1723116T3/pl unknown
- 2005-02-25 BR BRPI0508225-0A patent/BRPI0508225A/pt not_active Application Discontinuation
- 2005-02-25 SI SI200530520T patent/SI1723116T1/sl unknown
- 2005-02-25 AR ARP050100694A patent/AR049006A1/es unknown
- 2005-02-25 DK DK05717798T patent/DK1723116T3/da active
- 2005-02-25 KR KR1020067017249A patent/KR100846347B1/ko not_active Expired - Fee Related
- 2005-02-25 ES ES05717798T patent/ES2315853T3/es not_active Expired - Lifetime
- 2005-02-25 UY UY28775A patent/UY28775A1/es unknown
- 2005-02-25 AT AT05717798T patent/ATE409182T1/de active
- 2005-02-25 PT PT05717798T patent/PT1723116E/pt unknown
- 2005-02-25 EA EA200601556A patent/EA010656B1/ru not_active IP Right Cessation
- 2005-02-25 US US11/066,899 patent/US7598384B2/en not_active Expired - Fee Related
- 2005-02-25 AU AU2005217199A patent/AU2005217199B2/en not_active Ceased
- 2005-02-25 UA UAA200610294A patent/UA83549C2/uk unknown
- 2005-02-25 EP EP05717798A patent/EP1723116B1/en not_active Expired - Lifetime
- 2005-02-25 JP JP2007500295A patent/JP4712027B2/ja not_active Expired - Fee Related
- 2005-02-25 DE DE602005009929T patent/DE602005009929D1/de not_active Expired - Lifetime
- 2005-02-25 WO PCT/GB2005/000717 patent/WO2005082856A2/en not_active Ceased
- 2005-02-25 CA CA2556653A patent/CA2556653C/en not_active Expired - Fee Related
-
2006
- 2006-08-11 ZA ZA200606686A patent/ZA200606686B/xx unknown
- 2006-08-16 IL IL177524A patent/IL177524A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AR049006A1 (es) | 2006-06-21 |
| JP4712027B2 (ja) | 2011-06-29 |
| PL1723116T3 (pl) | 2009-04-30 |
| ES2315853T3 (es) | 2009-04-01 |
| IL177524A0 (en) | 2006-12-10 |
| US20050197361A1 (en) | 2005-09-08 |
| WO2005082856A3 (en) | 2005-11-24 |
| JP2007524710A (ja) | 2007-08-30 |
| CA2556653A1 (en) | 2005-09-09 |
| BRPI0508225A (pt) | 2007-07-17 |
| KR100846347B1 (ko) | 2008-07-15 |
| SI1723116T1 (sl) | 2009-04-30 |
| ZA200606686B (en) | 2008-01-30 |
| DK1723116T3 (da) | 2009-02-02 |
| EP1723116A2 (en) | 2006-11-22 |
| DE602005009929D1 (de) | 2008-11-06 |
| EA010656B1 (ru) | 2008-10-30 |
| CA2556653C (en) | 2011-08-16 |
| PT1723116E (pt) | 2009-01-02 |
| US7598384B2 (en) | 2009-10-06 |
| UY28775A1 (es) | 2005-04-29 |
| KR20070001975A (ko) | 2007-01-04 |
| TWI301760B (en) | 2008-10-11 |
| EA200601556A1 (ru) | 2007-02-27 |
| IL177524A (en) | 2012-02-29 |
| EP1723116B1 (en) | 2008-09-24 |
| AU2005217199B2 (en) | 2008-06-26 |
| CN1922146A (zh) | 2007-02-28 |
| WO2005082856A2 (en) | 2005-09-09 |
| TW200534857A (en) | 2005-11-01 |
| ATE409182T1 (de) | 2008-10-15 |
| AU2005217199A1 (en) | 2005-09-09 |
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