UY28775A1 - Tetrahidroquinolinonas y su uso como antagonistas de receptores de glutamato metabotropico - Google Patents

Tetrahidroquinolinonas y su uso como antagonistas de receptores de glutamato metabotropico

Info

Publication number
UY28775A1
UY28775A1 UY28775A UY28775A UY28775A1 UY 28775 A1 UY28775 A1 UY 28775A1 UY 28775 A UY28775 A UY 28775A UY 28775 A UY28775 A UY 28775A UY 28775 A1 UY28775 A1 UY 28775A1
Authority
UY
Uruguay
Prior art keywords
antagonists
tetrahydrochinolinones
metabotropic glutamate
glutamate receptors
compounds
Prior art date
Application number
UY28775A
Other languages
English (en)
Spanish (es)
Inventor
Aigars Jirgensons
Christopher Parsons
Ieva Jauzeme
Ivars Kalvinsh
Maksims Vanejevs
Markus Henrich
Tanja Weil
Valerjans Kauss
Wojciech Danysz
Original Assignee
Merz Pharma Gmbh & Amp
Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Amp, Co Kgaa filed Critical Merz Pharma Gmbh & Amp
Publication of UY28775A1 publication Critical patent/UY28775A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
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UY28775A 2004-02-27 2005-02-25 Tetrahidroquinolinonas y su uso como antagonistas de receptores de glutamato metabotropico UY28775A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54878804P 2004-02-27 2004-02-27

Publications (1)

Publication Number Publication Date
UY28775A1 true UY28775A1 (es) 2005-04-29

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CA2556653A1 (en) 2005-09-09
EP1723116A2 (en) 2006-11-22
JP4712027B2 (ja) 2011-06-29
PL1723116T3 (pl) 2009-04-30
US7598384B2 (en) 2009-10-06
SI1723116T1 (sl) 2009-04-30
KR20070001975A (ko) 2007-01-04
CA2556653C (en) 2011-08-16
KR100846347B1 (ko) 2008-07-15
AU2005217199A1 (en) 2005-09-09
IL177524A0 (en) 2006-12-10
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DK1723116T3 (da) 2009-02-02
JP2007524710A (ja) 2007-08-30
TW200534857A (en) 2005-11-01
EA010656B1 (ru) 2008-10-30
UA83549C2 (uk) 2008-07-25
WO2005082856A3 (en) 2005-11-24
IL177524A (en) 2012-02-29
PT1723116E (pt) 2009-01-02
BRPI0508225A (pt) 2007-07-17
AU2005217199B2 (en) 2008-06-26
US20050197361A1 (en) 2005-09-08
EA200601556A1 (ru) 2007-02-27
WO2005082856A2 (en) 2005-09-09
CN1922146A (zh) 2007-02-28
ATE409182T1 (de) 2008-10-15
ES2315853T3 (es) 2009-04-01
TWI301760B (en) 2008-10-11
ZA200606686B (en) 2008-01-30
AR049006A1 (es) 2006-06-21
DE602005009929D1 (de) 2008-11-06

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