EA200800660A1 - Тетрагидрохинолиноны и их применение в качестве модуляторов метаботропных глутаматных рецепторов - Google Patents

Тетрагидрохинолиноны и их применение в качестве модуляторов метаботропных глутаматных рецепторов

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Publication number
EA200800660A1
EA200800660A1 EA200800660A EA200800660A EA200800660A1 EA 200800660 A1 EA200800660 A1 EA 200800660A1 EA 200800660 A EA200800660 A EA 200800660A EA 200800660 A EA200800660 A EA 200800660A EA 200800660 A1 EA200800660 A1 EA 200800660A1
Authority
EA
Eurasian Patent Office
Prior art keywords
modulators
tetrahydrochinolinones
application
metabotropic glutamate
glutamate receptors
Prior art date
Application number
EA200800660A
Other languages
English (en)
Inventor
Кристофер Грахам Рафаэль Парсонс
Айгарс Йиргенсонс
Иева Яунземе
Иварс Калвиньш
Маркус Хенрих
Максимс Ванейевс
Таня Вайль
Валерьянс Каусс
Войцех Даныш
Клаудиа Ятцке
Original Assignee
Мерц Фарма Гмбх Унд Ко. Кгаа
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерц Фарма Гмбх Унд Ко. Кгаа filed Critical Мерц Фарма Гмбх Унд Ко. Кгаа
Publication of EA200800660A1 publication Critical patent/EA200800660A1/ru

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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/47—Quinolines; Isoquinolines
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Abstract

Настоящее изобретение относится к этинилзамещенным производным тетрагидрохинолинона, а также к их фармацевтически приемлемым солям. Настоящее изобретение далее относится к способу получения таких соединений. Соединения по настоящему изобретению являются модуляторами mGluR группы I, а потому применимы для лечения и предотвращения острых и/или хронических неврологических нарушений.
EA200800660A 2005-08-24 2006-08-24 Тетрагидрохинолиноны и их применение в качестве модуляторов метаботропных глутаматных рецепторов EA200800660A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2005/003285 WO2007023242A1 (en) 2005-08-24 2005-08-24 Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
PCT/GB2006/003170 WO2007023290A1 (en) 2005-08-24 2006-08-24 Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors

Publications (1)

Publication Number Publication Date
EA200800660A1 true EA200800660A1 (ru) 2008-06-30

Family

ID=36273537

Family Applications (1)

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EA200800660A EA200800660A1 (ru) 2005-08-24 2006-08-24 Тетрагидрохинолиноны и их применение в качестве модуляторов метаботропных глутаматных рецепторов

Country Status (15)

Country Link
EP (1) EP1931635A1 (ru)
JP (1) JP2009506018A (ru)
KR (1) KR20080031972A (ru)
CN (1) CN101223142A (ru)
AR (1) AR056044A1 (ru)
AU (1) AU2006283359B2 (ru)
BR (1) BRPI0615059A2 (ru)
CA (1) CA2610873C (ru)
EA (1) EA200800660A1 (ru)
IL (1) IL189617A (ru)
MX (1) MX2008001871A (ru)
NO (1) NO20081428L (ru)
TW (1) TWI329635B (ru)
WO (2) WO2007023242A1 (ru)
ZA (1) ZA200710668B (ru)

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US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
MX2012007005A (es) * 2009-12-18 2012-07-03 Janssen Pharmaceutica Nv Tiazoles biciclicos como moduladores alostericos de recptores de glutamato metabotropico subtipo 5.
KR20120097400A (ko) * 2009-12-18 2012-09-03 얀센 파마슈티카 엔.브이. Ｍｇｌｕｒ５ 리셉터의 알로스테릭 조절자로서의 비사이클릭 티아졸
WO2011075699A2 (en) 2009-12-18 2011-06-23 Sunovion Pharmaceuticals Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
EP2531510B1 (en) 2010-02-01 2014-07-23 Novartis AG Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
US8835444B2 (en) 2010-02-02 2014-09-16 Novartis Ag Cyclohexyl amide derivatives as CRF receptor antagonists
WO2012052451A1 (en) 2010-10-18 2012-04-26 Merz Pharma Gmbh & Co. Kgaa Metabotropic glutamate receptor modulators
WO2012139876A1 (en) 2011-04-14 2012-10-18 Merz Pharma Gmbh & Co. Kgaa Enteric formulations of metabotropic glutamate receptor modulators
WO2012172093A1 (en) * 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
WO2013050527A1 (en) 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors
EP2650284A1 (en) * 2012-04-10 2013-10-16 Merz Pharma GmbH & Co. KGaA Heterocyclic derivatives as metabotropic glutamate receptor modulators
KR101418078B1 (ko) * 2013-01-23 2014-07-10 한국과학기술연구원 ｍＧｌｕＲ5 길항제로서의 2-(치환된에티닐)퀴놀린 유도체
KR20160110357A (ko) 2013-11-15 2016-09-21 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 Ｅｂｎａ１ 억제제 및 그의 사용 방법
KR101579496B1 (ko) * 2014-07-03 2015-12-23 한국과학기술연구원 ｍＧlｕＲ5의 표식용 방사성 조성물
WO2016154527A1 (en) * 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors
US10442763B2 (en) 2015-05-14 2019-10-15 The Wistar Institute Of Anatomy And Biology EBNA1 inhibitors and methods using same
NZ738563A (en) 2015-06-03 2019-09-27 Bristol Myers Squibb Co 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders
EP3459939A1 (en) * 2017-09-26 2019-03-27 Pragma Therapeutics Novel heterocyclic compounds as modulators of mglur7
US11242338B2 (en) 2018-05-17 2022-02-08 The Wistar Institute EBNA1 inhibitor crystalline forms, and methods of preparing and using same
WO2021080312A1 (ko) 2019-10-21 2021-04-29 에스케이바이오팜 주식회사 인지 장애의 예방, 경감 또는 치료, 또는 인지 기능 향상을 위한 이미다조피리미딘 또는 이미다조트리아진 화합물의 용도
JP2022552877A (ja) * 2019-10-21 2022-12-20 エスケー バイオファーマスティカルズ カンパニー リミテッド 発達障害の予防、軽減又は治療のためのイミダゾピリミジン又はイミダゾトリアジン化合物の使用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA007464B1 (ru) * 2000-10-02 2006-10-27 Янссен Фармацевтика Н.В. Антагонисты метаботропных рецепторов глутамата
TWI301760B (en) * 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors

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MX2008001871A (es) 2008-04-09
WO2007023290A1 (en) 2007-03-01
KR20080031972A (ko) 2008-04-11
TW200728283A (en) 2007-08-01
NO20081428L (no) 2008-03-18
AU2006283359A1 (en) 2007-03-01
ZA200710668B (en) 2009-08-26
CN101223142A (zh) 2008-07-16
CA2610873C (en) 2010-08-03
AU2006283359B2 (en) 2010-05-27
IL189617A (en) 2012-08-30
CA2610873A1 (en) 2007-03-01
WO2007023242A1 (en) 2007-03-01
EP1931635A1 (en) 2008-06-18
BRPI0615059A2 (pt) 2011-04-26
TWI329635B (en) 2010-09-01
AR056044A1 (es) 2007-09-12
JP2009506018A (ja) 2009-02-12
IL189617A0 (en) 2008-06-05

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