NO20081428L - Tetrahydrokinolinoner og anvendelse derav som modulatorer av metabotrope glutamatreseptorer - Google Patents

Tetrahydrokinolinoner og anvendelse derav som modulatorer av metabotrope glutamatreseptorer

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Publication number
NO20081428L
NO20081428L NO20081428A NO20081428A NO20081428L NO 20081428 L NO20081428 L NO 20081428L NO 20081428 A NO20081428 A NO 20081428A NO 20081428 A NO20081428 A NO 20081428A NO 20081428 L NO20081428 L NO 20081428L
Authority
NO
Norway
Prior art keywords
modulators
tetrahydroquinolinones
metabotropic glutamate
glutamate receptors
compounds
Prior art date
Application number
NO20081428A
Other languages
English (en)
Inventor
Wojciech Danysz
Ivars Kalvinsh
Valerjans Kauss
Aigars Jirgensons
Christopher Graham Raphael Parsons
Maksims Vanejevs
Ieva Jaunzeme
Markus Henrich
Tanja Weil
Claudia Jatzke
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Publication of NO20081428L publication Critical patent/NO20081428L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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Abstract

Oppfinnelsen gjelder etynylsubstituerte tetrahydrokinolinonderivater, så vel som deres farmasøytisk akseptable salter. Oppfinnelsen gj elder videre en fremgangsmåte for fremstilling av slike forbindelser. Forbindelsene ifølge oppfinnelsen er gruppe I-mGluR-modulatorer og er følgelig anvendbare for kontroll og forebyggelse av akutte og/eller kroniske, nevrologiske forstyrrelser .
NO20081428A 2005-08-24 2008-03-18 Tetrahydrokinolinoner og anvendelse derav som modulatorer av metabotrope glutamatreseptorer NO20081428L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/GB2005/003285 WO2007023242A1 (en) 2005-08-24 2005-08-24 Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors
PCT/GB2006/003170 WO2007023290A1 (en) 2005-08-24 2006-08-24 Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors

Publications (1)

Publication Number Publication Date
NO20081428L true NO20081428L (no) 2008-03-18

Family

ID=36273537

Family Applications (1)

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NO20081428A NO20081428L (no) 2005-08-24 2008-03-18 Tetrahydrokinolinoner og anvendelse derav som modulatorer av metabotrope glutamatreseptorer

Country Status (15)

Country Link
EP (1) EP1931635A1 (no)
JP (1) JP2009506018A (no)
KR (1) KR20080031972A (no)
CN (1) CN101223142A (no)
AR (1) AR056044A1 (no)
AU (1) AU2006283359B2 (no)
BR (1) BRPI0615059A2 (no)
CA (1) CA2610873C (no)
EA (1) EA200800660A1 (no)
IL (1) IL189617A (no)
MX (1) MX2008001871A (no)
NO (1) NO20081428L (no)
TW (1) TWI329635B (no)
WO (2) WO2007023242A1 (no)
ZA (1) ZA200710668B (no)

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US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
KR20120097400A (ko) * 2009-12-18 2012-09-03 얀센 파마슈티카 엔.브이. Ｍｇｌｕｒ５ 리셉터의 알로스테릭 조절자로서의 비사이클릭 티아졸
EP2513118B1 (en) * 2009-12-18 2013-09-18 Janssen Pharmaceutica, N.V. Bicyclic thiazoles as allosteric modulators of mglur5 receptors
US8772301B2 (en) 2009-12-18 2014-07-08 Sunovion Pharmaceuticals, Inc. Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
AR080055A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
AR083475A1 (es) 2010-10-18 2013-02-27 Merz Pharma Gmbh & Co Kgaa Moduladores de receptores de glutamato metabotropicos
WO2012139876A1 (en) 2011-04-14 2012-10-18 Merz Pharma Gmbh & Co. Kgaa Enteric formulations of metabotropic glutamate receptor modulators
WO2012172093A1 (en) * 2011-06-17 2012-12-20 Merz Pharma Gmbh & Co. Kgaa Dihydroindolizine derivate as metabotropic glutamate receptor modulators
WO2013050527A1 (en) 2011-10-05 2013-04-11 H. Lundbeck A/S Quinazoline derivatives as pde10a enzyme inhibitors
EP2650284A1 (en) * 2012-04-10 2013-10-16 Merz Pharma GmbH & Co. KGaA Heterocyclic derivatives as metabotropic glutamate receptor modulators
KR101418078B1 (ko) * 2013-01-23 2014-07-10 한국과학기술연구원 ｍＧｌｕＲ5 길항제로서의 2-(치환된에티닐)퀴놀린 유도체
KR20160110357A (ko) * 2013-11-15 2016-09-21 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 Ｅｂｎａ１ 억제제 및 그의 사용 방법
KR101579496B1 (ko) * 2014-07-03 2015-12-23 한국과학기술연구원 ｍＧlｕＲ5의 표식용 방사성 조성물
EP3285582B1 (en) 2015-03-26 2020-11-11 Merck Sharp & Dohme Corp. Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors
MX2017014550A (es) 2015-05-14 2018-02-26 Wistar Inst Inhibidores del antigeno nuclear epstein-barr 1 (ebna1) y metodos que los utilizan.
SI3303330T1 (sl) 2015-06-03 2019-08-30 Bristol-Myers Squibb Company Agonisti 4-hidroksi-3-(heteroaril)piridin-2-on apj za uporabo pri zdravljenju kardiovaskularnih motenj
EP3459939A1 (en) * 2017-09-26 2019-03-27 Pragma Therapeutics Novel heterocyclic compounds as modulators of mglur7
EP3793546A4 (en) 2018-05-17 2021-12-08 The Wistar Institute CRYSTALLINE FORMS OF EBNA1-INHIBITOR AND METHOD OF MANUFACTURING AND USING THEREOF
AU2020370958A1 (en) 2019-10-21 2022-06-09 Sk Biopharmaceuticals Co., Ltd. Use of imidazopyrimidine or imidazotriazine compounds for prevention, alleviation, or treatment of cognitive disorders, or for improving cognitive function
KR20220086607A (ko) * 2019-10-21 2022-06-23 에스케이바이오팜 주식회사 발달 장애의 예방, 경감 또는 치료를 위한 이미다조피리미딘 또는 이미다조트리아진 화합물의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0114253A (pt) * 2000-10-02 2003-07-01 Janssen Pharmaceutica Nv Antagonistas de receptor de glutamato metabotrópico
TWI301760B (en) * 2004-02-27 2008-10-11 Merz Pharma Gmbh & Co Kgaa Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors

Also Published As

Publication number Publication date
EA200800660A1 (ru) 2008-06-30
TWI329635B (en) 2010-09-01
WO2007023290A1 (en) 2007-03-01
KR20080031972A (ko) 2008-04-11
CN101223142A (zh) 2008-07-16
AU2006283359B2 (en) 2010-05-27
CA2610873C (en) 2010-08-03
WO2007023242A1 (en) 2007-03-01
AU2006283359A1 (en) 2007-03-01
JP2009506018A (ja) 2009-02-12
EP1931635A1 (en) 2008-06-18
CA2610873A1 (en) 2007-03-01
MX2008001871A (es) 2008-04-09
IL189617A0 (en) 2008-06-05
BRPI0615059A2 (pt) 2011-04-26
AR056044A1 (es) 2007-09-12
ZA200710668B (en) 2009-08-26
TW200728283A (en) 2007-08-01
IL189617A (en) 2012-08-30

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