SE0502254L - Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission - Google Patents

Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission

Info

Publication number
SE0502254L
SE0502254L SE0502254A SE0502254A SE0502254L SE 0502254 L SE0502254 L SE 0502254L SE 0502254 A SE0502254 A SE 0502254A SE 0502254 A SE0502254 A SE 0502254A SE 0502254 L SE0502254 L SE 0502254L
Authority
SE
Sweden
Prior art keywords
piperidines
modulators
disubstituted phenyl
dopamine neurotransmission
new disubstituted
Prior art date
Application number
SE0502254A
Other languages
English (en)
Other versions
SE529246C2 (sv
Inventor
Clas Sonesson
Original Assignee
Carlsson A Research Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlsson A Research Ab filed Critical Carlsson A Research Ab
Priority to SE0502254A priority Critical patent/SE529246C2/sv
Priority to CN2006800352682A priority patent/CN101273014B/zh
Priority to US12/089,412 priority patent/US8501777B2/en
Priority to AT06806224T priority patent/ATE494277T1/de
Priority to EP06806224A priority patent/EP1948606B1/en
Priority to BRPI0617355-1A priority patent/BRPI0617355A2/pt
Priority to NZ566015A priority patent/NZ566015A/en
Priority to PL06806224T priority patent/PL1948606T3/pl
Priority to ZA200802238A priority patent/ZA200802238B/xx
Priority to DE602006019470T priority patent/DE602006019470D1/de
Priority to DK06806224.9T priority patent/DK1948606T3/da
Priority to PCT/EP2006/009866 priority patent/WO2007042295A1/en
Priority to ES06806224T priority patent/ES2358537T3/es
Priority to RU2008108618/04A priority patent/RU2418787C2/ru
Priority to CA002625663A priority patent/CA2625663A1/en
Priority to KR1020087008815A priority patent/KR20080046720A/ko
Priority to MYPI20081021A priority patent/MY143241A/en
Priority to AU2006301432A priority patent/AU2006301432B2/en
Priority to JP2008534935A priority patent/JP4857346B2/ja
Priority to UAA200801380A priority patent/UA93380C2/ru
Publication of SE0502254L publication Critical patent/SE0502254L/sv
Publication of SE529246C2 publication Critical patent/SE529246C2/sv
Priority to IL189298A priority patent/IL189298A0/en
Priority to NO20082174A priority patent/NO20082174L/no
Priority to HK09102390.3A priority patent/HK1125097A1/xx
Priority to HR20110196T priority patent/HRP20110196T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE0502254A 2005-10-13 2005-10-13 Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission SE529246C2 (sv)

Priority Applications (24)

Application Number Priority Date Filing Date Title
SE0502254A SE529246C2 (sv) 2005-10-13 2005-10-13 Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
PCT/EP2006/009866 WO2007042295A1 (en) 2005-10-13 2006-10-12 3, 5-disubstituted phenyl-piperidines as mdulators of dopamine? neurotransmission
CA002625663A CA2625663A1 (en) 2005-10-13 2006-10-12 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
RU2008108618/04A RU2418787C2 (ru) 2005-10-13 2006-10-12 3,5-дизамещенные фенилпиперидины в качестве модуляторов нейротрансмиссии допамина
EP06806224A EP1948606B1 (en) 2005-10-13 2006-10-12 3, 5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
US12/089,412 US8501777B2 (en) 2005-10-13 2006-10-12 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
NZ566015A NZ566015A (en) 2005-10-13 2006-10-12 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
PL06806224T PL1948606T3 (pl) 2005-10-13 2006-10-12 3,5-dwupodstawione fenylopiperydyny jako modulatory neurotransmisji dopaminy
KR1020087008815A KR20080046720A (ko) 2005-10-13 2006-10-12 도파민 신경전달의 조절제로서 3,5-이치환된 페닐-피페리딘
DE602006019470T DE602006019470D1 (de) 2005-10-13 2006-10-12 3, 5-disubstituierte phenyl-piperidine als modulatoren der dopamin- neurotransmission
DK06806224.9T DK1948606T3 (da) 2005-10-13 2006-10-12 3, 5-disubstituerede phenyl-piperidiner som modulatorer af dopaminneurotransmission
CN2006800352682A CN101273014B (zh) 2005-10-13 2006-10-12 作为多巴胺神经传递调节剂的3，5-二取代的苯基-哌啶
ES06806224T ES2358537T3 (es) 2005-10-13 2006-10-12 Fenil-piperidinas 3,5-disustituidas como moduladores de neurotransmisión de dopamina.
AT06806224T ATE494277T1 (de) 2005-10-13 2006-10-12 3, 5-disubstituierte phenyl-piperidine als modulatoren der dopamin- neurotransmission
BRPI0617355-1A BRPI0617355A2 (pt) 2005-10-13 2006-10-12 composto, uso de um composto, e, composiÇço farmacÊutica
ZA200802238A ZA200802238B (en) 2005-10-13 2006-10-12 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
MYPI20081021A MY143241A (en) 2005-10-13 2006-10-12 3, 5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
AU2006301432A AU2006301432B2 (en) 2005-10-13 2006-10-12 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
JP2008534935A JP4857346B2 (ja) 2005-10-13 2006-10-12 ドーパミン神経伝達のモジュレーターとしての３，５−二置換フェニル−ピペリジン
UAA200801380A UA93380C2 (en) 2005-10-13 2006-12-10 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
IL189298A IL189298A0 (en) 2005-10-13 2008-02-05 3.5-disubstituted phenyl-piperidines as modulators of dopamine meurotransmission
NO20082174A NO20082174L (no) 2005-10-13 2008-05-09 3,5-disubstituerte fenylpiperidiner som modulatorer av dopamin-neurotransmisjon
HK09102390.3A HK1125097A1 (en) 2005-10-13 2009-03-12 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
HR20110196T HRP20110196T1 (hr) 2005-10-13 2011-03-16 3,5-disupstituirani fenil-piperidini kao modulatori dopamina neurotransmisije

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0502254A SE529246C2 (sv) 2005-10-13 2005-10-13 Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission

Publications (2)

Publication Number Publication Date
SE0502254L true SE0502254L (sv) 2007-04-14
SE529246C2 SE529246C2 (sv) 2007-06-12

Family

ID=37467527

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0502254A SE529246C2 (sv) 2005-10-13 2005-10-13 Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission

Country Status (24)

Country Link
US (1) US8501777B2 (sv)
EP (1) EP1948606B1 (sv)
JP (1) JP4857346B2 (sv)
KR (1) KR20080046720A (sv)
CN (1) CN101273014B (sv)
AT (1) ATE494277T1 (sv)
AU (1) AU2006301432B2 (sv)
BR (1) BRPI0617355A2 (sv)
CA (1) CA2625663A1 (sv)
DE (1) DE602006019470D1 (sv)
DK (1) DK1948606T3 (sv)
ES (1) ES2358537T3 (sv)
HK (1) HK1125097A1 (sv)
HR (1) HRP20110196T1 (sv)
IL (1) IL189298A0 (sv)
MY (1) MY143241A (sv)
NO (1) NO20082174L (sv)
NZ (1) NZ566015A (sv)
PL (1) PL1948606T3 (sv)
RU (1) RU2418787C2 (sv)
SE (1) SE529246C2 (sv)
UA (1) UA93380C2 (sv)
WO (1) WO2007042295A1 (sv)
ZA (1) ZA200802238B (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
MXPA06013941A (es) 2004-06-08 2007-12-10 Neurosearch Sweden Ab Fenilpiperidinas disustituidas, novedosas, como moduladores de la neurotransmision de dopamina y serotonina.
SE0401465D0 (sv) 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
EP1802573B1 (en) 2004-10-13 2016-09-28 Teva Pharmaceuticals International GmbH Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-n-propyl-piperidine
CN101711236B (zh) * 2007-04-12 2012-10-31 Nsab神经研究瑞典公司分公司 表现出改善的心血管副作用特性的多巴胺受体稳定剂/调节剂的n-氧化物和/或二-n-氧化物衍生物
WO2009133109A1 (en) * 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
EP2271638B1 (en) * 2008-04-29 2011-08-31 NSAB, Filial af NeuroSearch Sweden AB, Sverige Modulators of dopamine neurotransmission
US8524766B2 (en) * 2008-04-29 2013-09-03 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
WO2011107583A1 (en) 2010-03-04 2011-09-09 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Substituted 4-phenyl-n-alkyl-piperidines for preventing onset or slowing progression of neurodegenerative disorders
EA201390332A1 (ru) 2010-09-03 2013-08-30 Ивакс Интернэшнл Гмбх Дейтерированные аналоги придопидина, применимые в качестве допаминергических стабилизаторов
AU2012306386B2 (en) 2011-09-07 2017-06-15 Teva Pharmaceuticals International Gmbh Polymorphic form of pridopidine hydrochloride
US9012476B2 (en) 2011-12-08 2015-04-21 IVAX International GmbH Hydrobromide salt of pridopidine
WO2013152105A1 (en) 2012-04-04 2013-10-10 IVAX International GmbH Pharmaceutical compositions for combination therapy
TW201613859A (en) * 2014-06-30 2016-04-16 Teva Pharma Analogs of PRIDOPIDINE, their preparation and use
CA3035099C (en) * 2016-08-24 2023-01-17 Prilenia Therapeutics Development Ltd. Use of pridopidine for treating dystonias
CN111343982A (zh) * 2017-09-08 2020-06-26 普瑞尼亚神经治疗有限公司 用于治疗药物诱发的异动症的普利多匹定

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EP1796669B1 (en) 2004-10-01 2010-09-22 Merck Sharp & Dohme Corp. Aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2006040156A1 (en) * 2004-10-13 2006-04-20 Neurosearch Sweden Ab Process for the synthesis of 4-(3-sulfonylphenyl)-piperidines
KR20080035576A (ko) 2005-08-05 2008-04-23 아스트라제네카 아베 트리사이클릭 벤즈이미다졸 및 대사체 글루타메이트 수용체조절제로서 이들의 용도
US20080269286A1 (en) 2005-12-07 2008-10-30 Clas Sonesson Disubstituted Phenylpiperidines as Modulators of Cortical Catecholaminergic Neurotransmission

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AU2006301432B2 (en) 2011-12-15
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