KR100846347B1 - 테트라히드로퀴놀리논 및 대사자극성 글루타메이트수용체의 길항제로서의 이들의 용도 - Google Patents
테트라히드로퀴놀리논 및 대사자극성 글루타메이트수용체의 길항제로서의 이들의 용도Info
- Publication number
- KR100846347B1 KR100846347B1 KR1020067017249A KR20067017249A KR100846347B1 KR 100846347 B1 KR100846347 B1 KR 100846347B1 KR 1020067017249 A KR1020067017249 A KR 1020067017249A KR 20067017249 A KR20067017249 A KR 20067017249A KR 100846347 B1 KR100846347 B1 KR 100846347B1
- Authority
- KR
- South Korea
- Prior art keywords
- quinolin
- dihydro
- dimethyl
- phenyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- Addiction (AREA)
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- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54878804P | 2004-02-27 | 2004-02-27 | |
| US60/548,788 | 2004-02-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20070001975A KR20070001975A (ko) | 2007-01-04 |
| KR100846347B1 true KR100846347B1 (ko) | 2008-07-15 |
Family
ID=34911013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067017249A Expired - Fee Related KR100846347B1 (ko) | 2004-02-27 | 2005-02-25 | 테트라히드로퀴놀리논 및 대사자극성 글루타메이트수용체의 길항제로서의 이들의 용도 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7598384B2 (https=) |
| EP (1) | EP1723116B1 (https=) |
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| WO2007023242A1 (en) * | 2005-08-24 | 2007-03-01 | Merz Pharma Gmbh & Co. Kgaa | Tetrahydroquinolinones and their use as modulators of metabotropic glutamate receptors |
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| AU2006303037A1 (en) * | 2005-10-21 | 2007-04-26 | Merz Pharma Gmbh & Co Kgaa | Chromenones and their use as modulators of metabotropic glutamate receptors |
| EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| TW200732313A (en) * | 2005-12-15 | 2007-09-01 | Astrazeneca Ab | Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| CN102838532A (zh) | 2006-11-24 | 2012-12-26 | Ac免疫有限公司 | 用于治疗与淀粉样物质或淀粉样蛋白有关的疾病的吡唑胺和噻唑胺衍生物 |
| CA2742897A1 (en) * | 2008-11-06 | 2010-05-14 | Astrazeneca Ab | Modulators of amyloid beta. |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| EP2311823A1 (en) * | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases |
| CA2782950A1 (en) | 2009-12-18 | 2011-06-23 | Janssen Pharmaceutica Nv | Bicyclic thiazoles as allosteric modulators of mglur5 receptors |
| KR20120101551A (ko) | 2009-12-18 | 2012-09-13 | 얀센 파마슈티카 엔.브이. | Mglur5 수용체의 알로스테릭 조절자로서 바이사이클릭 티아졸 |
| GB0922589D0 (en) * | 2009-12-23 | 2010-02-10 | Almac Discovery Ltd | Pharmaceutical compounds |
| WO2012052451A1 (en) | 2010-10-18 | 2012-04-26 | Merz Pharma Gmbh & Co. Kgaa | Metabotropic glutamate receptor modulators |
| BR112013011984A2 (pt) * | 2010-11-16 | 2016-08-30 | Ge Healthcare Ltd | composto, composição farmacêutica, e, métodos para fabricar um composto, para formação de imagem e para detectar agregados tau in vitro e/ou in vivo |
| WO2012139876A1 (en) | 2011-04-14 | 2012-10-18 | Merz Pharma Gmbh & Co. Kgaa | Enteric formulations of metabotropic glutamate receptor modulators |
| MX2015002555A (es) * | 2012-08-30 | 2015-06-23 | Nippon Shinyaku Co Ltd | Derivado de piridina y medicina. |
| AU2014211727B2 (en) * | 2013-02-04 | 2018-07-26 | Prexton Therapeutics Sa | Positive allosteric modulators of mGluR3 |
| CN104513200B (zh) * | 2013-09-26 | 2017-05-03 | 江苏苏中药业集团股份有限公司 | 取代丁烯酰胺的马来酸盐及其晶型 |
| TWI713455B (zh) | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
| SMT202100286T1 (it) | 2015-05-15 | 2021-07-12 | Aurigene Discovery Tech Ltd | Composti di tetraidrochinolinone sostituito come modulatori ror-gamma |
| SG11201803242TA (en) * | 2015-10-29 | 2018-05-30 | Effector Therapeutics Inc | Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of mnk1 and mnk2 |
| WO2017087808A1 (en) | 2015-11-20 | 2017-05-26 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers |
| WO2017189553A1 (en) * | 2016-04-25 | 2017-11-02 | Everon Biosciences, Inc. | Removal of senescence-associated macrophages |
| BR112019016707A2 (pt) | 2017-02-14 | 2020-04-07 | Effector Therapeutics Inc | inibidores de mnk substituídos por piperidina e métodos relacionados aos mesmos |
| TWI857981B (zh) | 2018-10-24 | 2024-10-11 | 美商伊凡克特治療公司 | Mnk抑制劑的結晶形式 |
| GB2600384A (en) | 2020-09-30 | 2022-05-04 | Vaderis Therapeutics Ag | Allosteric AKT inhibitors for use in the treatment of hereditary hemorrhagic telangiectasia |
| US20250241905A1 (en) * | 2022-06-23 | 2025-07-31 | The Cleveland Clinic Foundation | 3-beta-hsd1 inhibitors and compositions and uses thereof |
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| US3501479A (en) * | 1967-05-19 | 1970-03-17 | American Cyanamid Co | Dihydroquinolines and substituted dihydroquinolines and method of preparing the same |
| DE2001572A1 (de) | 1970-01-15 | 1971-07-22 | Agfa Gevaert Ag | Spektral sensibilisiertes lichtempfindliches Material |
| DE2449030A1 (de) | 1974-10-11 | 1976-05-20 | Schering Ag | Neue pyridin-derivate |
| WO1988002251A1 (en) | 1986-09-26 | 1988-04-07 | Ici Australia Operations Proprietary Limited | Sunscreen compositions and compounds for use therein |
| US5110815A (en) * | 1990-12-03 | 1992-05-05 | Hoechst-Roussel Pharmaceuticals Inc. | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use |
| US5216164A (en) * | 1990-12-03 | 1993-06-01 | Hoechst-Roussel Pharmaceuticals Incorporated | 5-amino-5,6,7,8-tetrahydroquinolines and related compounds |
| CA2316944A1 (en) * | 1998-02-20 | 1999-08-26 | Mitsuru Shiraishi | Aminoguanidinehydrazone derivative, production and use thereof |
| GB0003632D0 (en) | 2000-02-16 | 2000-04-05 | Univ Hong Kong Science & Techn | Dimeric compounds |
| CN1703403A (zh) * | 2000-10-02 | 2005-11-30 | 詹森药业有限公司 | 趋代谢的谷氨酸盐受体拮抗剂 |
| CN1642580B (zh) * | 2002-03-29 | 2010-05-26 | 詹森药业有限公司 | 放射性标记的喹啉和喹啉酮衍生物及其作为代谢性谷氨酸受体配体的制造用途 |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2556653A1 (en) | 2005-09-09 |
| EP1723116A2 (en) | 2006-11-22 |
| JP4712027B2 (ja) | 2011-06-29 |
| PL1723116T3 (pl) | 2009-04-30 |
| US7598384B2 (en) | 2009-10-06 |
| SI1723116T1 (sl) | 2009-04-30 |
| KR20070001975A (ko) | 2007-01-04 |
| CA2556653C (en) | 2011-08-16 |
| AU2005217199A1 (en) | 2005-09-09 |
| IL177524A0 (en) | 2006-12-10 |
| EP1723116B1 (en) | 2008-09-24 |
| DK1723116T3 (da) | 2009-02-02 |
| JP2007524710A (ja) | 2007-08-30 |
| TW200534857A (en) | 2005-11-01 |
| EA010656B1 (ru) | 2008-10-30 |
| UA83549C2 (uk) | 2008-07-25 |
| UY28775A1 (es) | 2005-04-29 |
| WO2005082856A3 (en) | 2005-11-24 |
| IL177524A (en) | 2012-02-29 |
| PT1723116E (pt) | 2009-01-02 |
| BRPI0508225A (pt) | 2007-07-17 |
| AU2005217199B2 (en) | 2008-06-26 |
| US20050197361A1 (en) | 2005-09-08 |
| EA200601556A1 (ru) | 2007-02-27 |
| WO2005082856A2 (en) | 2005-09-09 |
| CN1922146A (zh) | 2007-02-28 |
| ATE409182T1 (de) | 2008-10-15 |
| ES2315853T3 (es) | 2009-04-01 |
| TWI301760B (en) | 2008-10-11 |
| ZA200606686B (en) | 2008-01-30 |
| AR049006A1 (es) | 2006-06-21 |
| DE602005009929D1 (de) | 2008-11-06 |
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