EA201591204A3 - Новые хиральные n-ацил-5,6,7,(8-замещенные)-тетрагидро-[1,2,4]триазоло[4,3-а]пиразины как селективные антагонисты рецептора nk-3, фармацевтическая композиция, способы применения при нарушениях, опосредованных nk-3 рецепторами, и их хиральный синтез - Google Patents

Новые хиральные n-ацил-5,6,7,(8-замещенные)-тетрагидро-[1,2,4]триазоло[4,3-а]пиразины как селективные антагонисты рецептора nk-3, фармацевтическая композиция, способы применения при нарушениях, опосредованных nk-3 рецепторами, и их хиральный синтез

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Publication number
EA201591204A3
EA201591204A3 EA201591204A EA201591204A EA201591204A3 EA 201591204 A3 EA201591204 A3 EA 201591204A3 EA 201591204 A EA201591204 A EA 201591204A EA 201591204 A EA201591204 A EA 201591204A EA 201591204 A3 EA201591204 A3 EA 201591204A3
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Prior art keywords
pharmaceutical composition
antagonists
chiral
triazolo
tetrahydro
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EA201591204A
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English (en)
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EA030586B1 (ru
EA201591204A2 (ru
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Хамид Ховейда
Гийом Дутой
Грем Фразер
Мари-Одиль Рой
Мохамед Эль Бусмак
Фредерик Батт
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Евроскрин С.А.
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Publication of EA201591204A2 publication Critical patent/EA201591204A2/ru
Publication of EA201591204A3 publication Critical patent/EA201591204A3/ru
Publication of EA030586B1 publication Critical patent/EA030586B1/ru

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Abstract

Данное изобретение относится к новым соединениям формулы Iи их использованию в терапевтических целях. Данное изобретение также относится к новому способу хирального синтеза 5,6,7,(8-замещенных)-тетрагидро[1,2,4]триазоло[4,3-а]пиразинов с использованием N-sp3 защитных групп. Данное изобретение также относится к интермедиатам, использованным для синтеза соединений формулы I.
EA201591204A 2011-10-03 2012-10-03 Интермедиат для получения антагонистов рецептора нейрокинина-3 EA030586B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11183692 2011-10-03
EP11183681 2011-10-03
EP11183678 2011-10-03
EP11183679 2011-10-03
US201161543611P 2011-10-05 2011-10-05

Publications (3)

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EA201591204A2 EA201591204A2 (ru) 2016-01-29
EA201591204A3 true EA201591204A3 (ru) 2016-02-29
EA030586B1 EA030586B1 (ru) 2018-08-31

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EA201490579A EA029340B1 (ru) 2011-10-03 2012-10-03 ХИРАЛЬНЫЕ N-АЦИЛ-5,6,7,(8-ЗАМЕЩЕННЫЕ)-ТЕТРАГИДРО[1,2,4]ТРИАЗОЛО[4,3-a]ПИРАЗИНЫ КАК СЕЛЕКТИВНЫЕ АНТАГОНИСТЫ РЕЦЕПТОРА NK-3, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ПРИМЕНЕНИЯ ПРИ НАРУШЕНИЯХ, ОПОСРЕДОВАННЫХ NK-3 РЕЦЕПТОРАМИ, И ИХ ХИРАЛЬНЫЙ СИНТЕЗ
EA201591204A EA030586B1 (ru) 2011-10-03 2012-10-03 Интермедиат для получения антагонистов рецептора нейрокинина-3

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EA201490579A EA029340B1 (ru) 2011-10-03 2012-10-03 ХИРАЛЬНЫЕ N-АЦИЛ-5,6,7,(8-ЗАМЕЩЕННЫЕ)-ТЕТРАГИДРО[1,2,4]ТРИАЗОЛО[4,3-a]ПИРАЗИНЫ КАК СЕЛЕКТИВНЫЕ АНТАГОНИСТЫ РЕЦЕПТОРА NK-3, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ПРИМЕНЕНИЯ ПРИ НАРУШЕНИЯХ, ОПОСРЕДОВАННЫХ NK-3 РЕЦЕПТОРАМИ, И ИХ ХИРАЛЬНЫЙ СИНТЕЗ

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US (4) US9475814B2 (ru)
EP (2) EP2763992B9 (ru)
JP (2) JP6023814B2 (ru)
KR (1) KR102049534B1 (ru)
CN (2) CN103906750B9 (ru)
AU (1) AU2012320568C1 (ru)
BR (1) BR112014007652B1 (ru)
CA (1) CA2849751C (ru)
CY (1) CY1117773T1 (ru)
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EA (2) EA029340B1 (ru)
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HR (1) HRP20160396T1 (ru)
HU (1) HUE028858T2 (ru)
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PL (1) PL2763992T3 (ru)
RS (1) RS54833B1 (ru)
SI (1) SI2763992T1 (ru)
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WO (1) WO2013050424A1 (ru)

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CN112272670B (zh) * 2019-04-16 2023-12-12 上海翰森生物医药科技有限公司 含二并环类衍生物抑制剂、其制备方法和应用
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CN113527307A (zh) * 2020-04-20 2021-10-22 上海翰森生物医药科技有限公司 含三唑基的并环类衍生物抑制剂、其制备方法和应用
CN113549074A (zh) * 2020-04-26 2021-10-26 上海翰森生物医药科技有限公司 含三唑基的并环类衍生物抑制剂、其制备方法和应用
WO2022022680A1 (zh) * 2020-07-30 2022-02-03 上海翰森生物医药科技有限公司 含氮并环类衍生物抑制剂、其制备方法和应用
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