PL2763992T3 - Nowe chiralne N-acylo-5,6,7(8-podstawione)-tetrahydro- [1,2,4]triazolo[4,3-a]pirazyny jako selektywni antagoniści receptora NK-3, kompozycja farmaceutyczna i sposoby stosowania w zaburzeniach, w których pośredniczy receptor NK-3 - Google Patents
Nowe chiralne N-acylo-5,6,7(8-podstawione)-tetrahydro- [1,2,4]triazolo[4,3-a]pirazyny jako selektywni antagoniści receptora NK-3, kompozycja farmaceutyczna i sposoby stosowania w zaburzeniach, w których pośredniczy receptor NK-3Info
- Publication number
- PL2763992T3 PL2763992T3 PL12766991T PL12766991T PL2763992T3 PL 2763992 T3 PL2763992 T3 PL 2763992T3 PL 12766991 T PL12766991 T PL 12766991T PL 12766991 T PL12766991 T PL 12766991T PL 2763992 T3 PL2763992 T3 PL 2763992T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrazines
- triazolo
- tetrahydro
- acyl
- selective
- Prior art date
Links
- 102000002003 Neurokinin-3 Receptors Human genes 0.000 title 2
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title 2
- 230000001404 mediated effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003216 pyrazines Chemical class 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11183681 | 2011-10-03 | ||
| EP11183692 | 2011-10-03 | ||
| EP11183679 | 2011-10-03 | ||
| EP11183678 | 2011-10-03 | ||
| US201161543611P | 2011-10-05 | 2011-10-05 | |
| PCT/EP2012/069546 WO2013050424A1 (en) | 2011-10-03 | 2012-10-03 | NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF |
| EP12766991.9A EP2763992B9 (en) | 2011-10-03 | 2012-10-03 | Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, and methods for use in nk-3 receptor mediated disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2763992T3 true PL2763992T3 (pl) | 2016-08-31 |
Family
ID=48043185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12766991T PL2763992T3 (pl) | 2011-10-03 | 2012-10-03 | Nowe chiralne N-acylo-5,6,7(8-podstawione)-tetrahydro- [1,2,4]triazolo[4,3-a]pirazyny jako selektywni antagoniści receptora NK-3, kompozycja farmaceutyczna i sposoby stosowania w zaburzeniach, w których pośredniczy receptor NK-3 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US9475814B2 (pl) |
| EP (2) | EP2763992B9 (pl) |
| JP (2) | JP6023814B2 (pl) |
| KR (1) | KR102049534B1 (pl) |
| CN (2) | CN105175421B (pl) |
| AU (1) | AU2012320568C1 (pl) |
| BR (1) | BR112014007652B1 (pl) |
| CA (1) | CA2849751C (pl) |
| CY (1) | CY1117773T1 (pl) |
| DK (1) | DK2763992T3 (pl) |
| EA (2) | EA030586B1 (pl) |
| ES (1) | ES2572604T3 (pl) |
| HR (1) | HRP20160396T1 (pl) |
| HU (1) | HUE028858T2 (pl) |
| MX (1) | MX367774B (pl) |
| PL (1) | PL2763992T3 (pl) |
| RS (1) | RS54833B1 (pl) |
| SI (1) | SI2763992T1 (pl) |
| SM (1) | SMT201600164B (pl) |
| WO (1) | WO2013050424A1 (pl) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| EP2552920B1 (en) | 2010-04-02 | 2017-03-15 | Ogeda Sa | Novel nk-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in nk-3 receptors mediated disorders |
| HUE028858T2 (hu) | 2011-10-03 | 2017-01-30 | Euroscreen Sa | Új királis N-acil-5,6,7,(8-szubsztituált)-tetrahidro-[1,2,4]triazolo[4,3-A]pirazinok mint szelektív NK-3 receptor antagonisták, gyógyászati készítmény és eljárások NK-3 receptor által közvetített rendellenességek során történõ alkalmazásra |
| NO2948455T3 (pl) | 2013-03-29 | 2018-02-24 | ||
| AU2014242907B2 (en) | 2013-03-29 | 2018-06-28 | Ogeda Sa | Novel N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
| CA2907814C (en) | 2013-03-29 | 2021-07-13 | Euroscreen Sa | Novel n-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders |
| US10183948B2 (en) | 2013-03-29 | 2019-01-22 | Ogeda Sa | N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists |
| GB201315846D0 (en) | 2013-09-05 | 2013-10-23 | Imp Innovations Ltd | Method for treating or preventing hot flushes |
| ES2711095T3 (es) * | 2014-09-25 | 2019-04-30 | Ogeda Sa | Nueva síntesis quiral de N-acil-(3-sustituida)-(8-sustituida)-5,6-dihidro-[1,2,4]triazolo [4,3-a] pirazinas |
| SMT202300471T1 (it) | 2015-03-16 | 2024-03-13 | Ogeda N V | Antagonisti del recettore nk-3 per il trattamento terapeutico o cosmetico del grasso corporeo in eccesso |
| JP2021014404A (ja) * | 2017-10-13 | 2021-02-12 | アステラス製薬株式会社 | トリアゾロピラジン誘導体の塩及び結晶 |
| MY205440A (en) | 2018-09-28 | 2024-10-21 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
| CA3123757A1 (en) * | 2018-12-21 | 2020-06-25 | Ogeda Sa | Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof |
| CN111499640A (zh) * | 2019-01-31 | 2020-08-07 | 上海医药工业研究院 | 哌嗪并三唑类衍生物的手性拆分方法 |
| WO2020211798A1 (zh) * | 2019-04-16 | 2020-10-22 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
| AU2020358948A1 (en) | 2019-09-30 | 2022-05-26 | Janssen Pharmaceutica Nv | Radiolabelled MGL PET ligands |
| CN113527307B (zh) * | 2020-04-20 | 2024-10-11 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
| CN113549074A (zh) * | 2020-04-26 | 2021-10-26 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
| KR20230044443A (ko) * | 2020-07-30 | 2023-04-04 | 상하이 한서 바이오메디컬 컴퍼니 리미티드 | 질소-함유 융합된 고리 유도체 억제제, 이의 제조 방법 및 이의 용도 |
| KR102910851B1 (ko) * | 2021-04-21 | 2026-01-09 | 장춘 진사이언스 파마슈티컬 씨오., 엘티디. | 이미다졸 함유 축합고리계 유도체, 이의 제조방법 및 이의 의약적 용도 |
| CN120787232A (zh) * | 2023-03-10 | 2025-10-14 | 山东绿叶制药有限公司 | Nk-3受体拮抗剂化合物、药物组合物、其制备方法和应用 |
| EP4741382A1 (en) * | 2023-07-03 | 2026-05-13 | AGC Inc. | Novel method for producing 3-methyl-1,2,4-thiadiazole-5-carbohydrazide |
| EP4741381A1 (en) * | 2023-07-03 | 2026-05-13 | AGC Inc. | Novel method for producing 3-methyl-1,2,4-thiadiazole-5-carbohydrazide |
| EP4628491A1 (en) | 2024-04-05 | 2025-10-08 | Química Sintética, S.A. | Synthesis of intermediates for the preparation of neurokinin-3 receptor antagonists |
| CN118290429B (zh) * | 2024-06-06 | 2024-10-11 | 山东百诺医药股份有限公司 | 非唑奈坦中间体及非唑奈坦的制备方法 |
| CN121108124A (zh) * | 2024-07-11 | 2025-12-12 | 深圳市华先医药科技有限公司 | 一种构建非唑奈坦手性片段的路线及其中间体和制备方法 |
| CN118955563B (zh) * | 2024-10-16 | 2025-02-11 | 上海翰森生物医药科技有限公司 | 一种含氮并环类衍生物的制备方法 |
| CN119775279B (zh) * | 2024-12-20 | 2025-12-30 | 上海皓元医药股份有限公司 | 一种利用手性辅基合成非唑奈坦及其中间体的方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CA2907814C (en) | 2013-03-29 | 2021-07-13 | Euroscreen Sa | Novel n-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders |
| NO2948455T3 (pl) | 2013-03-29 | 2018-02-24 | ||
| AU2014242907B2 (en) | 2013-03-29 | 2018-06-28 | Ogeda Sa | Novel N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
| ES2711095T3 (es) | 2014-09-25 | 2019-04-30 | Ogeda Sa | Nueva síntesis quiral de N-acil-(3-sustituida)-(8-sustituida)-5,6-dihidro-[1,2,4]triazolo [4,3-a] pirazinas |
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