BR112014007652A2 - n-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmos - Google Patents
n-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmosInfo
- Publication number
- BR112014007652A2 BR112014007652A2 BR112014007652A BR112014007652A BR112014007652A2 BR 112014007652 A2 BR112014007652 A2 BR 112014007652A2 BR 112014007652 A BR112014007652 A BR 112014007652A BR 112014007652 A BR112014007652 A BR 112014007652A BR 112014007652 A2 BR112014007652 A2 BR 112014007652A2
- Authority
- BR
- Brazil
- Prior art keywords
- chiral
- pyrazines
- triazolo
- innovative
- tetrahydro
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
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- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61/453,611 | 2011-03-17 | ||
| EP11183681 | 2011-10-03 | ||
| EP11183692 | 2011-10-03 | ||
| EP11183679.7 | 2011-10-03 | ||
| EP11183679 | 2011-10-03 | ||
| EP11183681.3 | 2011-10-03 | ||
| EP11183692.0 | 2011-10-03 | ||
| EP11183678.9 | 2011-10-03 | ||
| EP11183678 | 2011-10-03 | ||
| US201161543611P | 2011-10-05 | 2011-10-05 | |
| PCT/EP2012/069546 WO2013050424A1 (en) | 2011-10-03 | 2012-10-03 | NOVEL CHIRAL N-ACYL-5,6,7,(8-SUBSTITUTED)-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR MEDIATED DISORDERS AND CHIRAL SYNTHESIS THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112014007652A2 true BR112014007652A2 (pt) | 2017-04-11 |
| BR112014007652A8 BR112014007652A8 (pt) | 2018-01-23 |
| BR112014007652B1 BR112014007652B1 (pt) | 2022-05-17 |
Family
ID=48043185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014007652-9A BR112014007652B1 (pt) | 2011-10-03 | 2012-10-03 | N-acil-5,6,7, (8-substituído) - tetraidro-[1,2,4] triazolo [4,3 -a] pirazinas quirais inovadoras como antagonistas de receptor de nk-3 seletivos, composição farmacêutica, métodos para usar em distúrbios mediados por receptor de nk-3 e síntese quiral dos mesmos |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9475814B2 (pt) |
| EP (2) | EP2763992B9 (pt) |
| JP (2) | JP6023814B2 (pt) |
| KR (1) | KR102049534B1 (pt) |
| CN (2) | CN103906750B9 (pt) |
| AU (1) | AU2012320568C1 (pt) |
| BR (1) | BR112014007652B1 (pt) |
| CA (1) | CA2849751C (pt) |
| CY (1) | CY1117773T1 (pt) |
| DK (1) | DK2763992T3 (pt) |
| EA (2) | EA029340B1 (pt) |
| ES (1) | ES2572604T3 (pt) |
| HK (1) | HK1197676A1 (pt) |
| HR (1) | HRP20160396T1 (pt) |
| HU (1) | HUE028858T2 (pt) |
| MX (1) | MX367774B (pt) |
| PL (1) | PL2763992T3 (pt) |
| RS (1) | RS54833B1 (pt) |
| SI (1) | SI2763992T1 (pt) |
| SM (1) | SMT201600164B (pt) |
| WO (1) | WO2013050424A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| PL2552920T3 (pl) | 2010-04-02 | 2017-08-31 | Ogeda Sa | Nowe wybiórcze związki antagonistów receptora NK-3, farmaceutyczne kompozycje i sposoby do zastosowania w zaburzeniach pośredniczonych przez receptory NK-3 |
| ES2572604T3 (es) | 2011-10-03 | 2016-06-01 | Euroscreen S.A. | Nuevas N-acil-5,6,7,(8-sustituido)-tetrahidro-[1,2,4]triazolo[4,3a]pirazinas quirales, como antagonistas selectivas del receptor de NK-3, composición farmacéutica y métodos para uso en trastornos mediados por el receptor de NK-3 |
| EP2978766B1 (en) | 2013-03-29 | 2018-12-19 | Ogeda Sa | N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders |
| US10183948B2 (en) | 2013-03-29 | 2019-01-22 | Ogeda Sa | N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists |
| US9840508B2 (en) | 2013-03-29 | 2017-12-12 | Oged Sa | N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a] pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
| MX370000B (es) | 2013-03-29 | 2019-11-28 | Ogeda S A | Novedosas n-acil-(3-sustituidas)-(8-sustituidas)-5,6-dihidro-[1,2, 4]triazolo[4,3-a]piracinas como antagonistas selectivos del receptor de nk-3, composición farmacéutica y métodos para su uso en trastornos mediados por el receptor de nk-3. |
| GB201315846D0 (en) | 2013-09-05 | 2013-10-23 | Imp Innovations Ltd | Method for treating or preventing hot flushes |
| EP3197876B1 (en) * | 2014-09-25 | 2018-11-28 | Ogeda Sa | Novel chiral synthesis of n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines |
| EP3271015B8 (en) | 2015-03-16 | 2023-11-01 | Ogeda N.V. | Nk-3 receptor antagonists for therapeutic or cosmetic treatment of excess body fat |
| JP2021014404A (ja) * | 2017-10-13 | 2021-02-12 | アステラス製薬株式会社 | トリアゾロピラジン誘導体の塩及び結晶 |
| AU2019410716A1 (en) | 2018-12-21 | 2021-07-22 | Ogeda Sa | Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof |
| CN111499640A (zh) * | 2019-01-31 | 2020-08-07 | 上海医药工业研究院 | 哌嗪并三唑类衍生物的手性拆分方法 |
| CN112272670B (zh) * | 2019-04-16 | 2023-12-12 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
| EP4038070A1 (en) * | 2019-09-30 | 2022-08-10 | Janssen Pharmaceutica NV | Radiolabelled mgl pet ligands |
| CN113527307A (zh) * | 2020-04-20 | 2021-10-22 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
| CN113549074A (zh) * | 2020-04-26 | 2021-10-26 | 上海翰森生物医药科技有限公司 | 含三唑基的并环类衍生物抑制剂、其制备方法和应用 |
| MX2023000867A (es) * | 2020-07-30 | 2023-02-22 | Shanghai Hansoh Biomedical Co Ltd | Inhibidor derivado de anillo fusionado que contiene nitrogeno, metodo de preparacion y uso del mismo. |
| JP2024514007A (ja) * | 2021-04-21 | 2024-03-27 | 長春金賽薬業有限責任公司 | イミダゾール含有縮合環系誘導体、その調製方法及びその医薬上の応用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3252483B2 (ja) | 1992-10-20 | 2002-02-04 | 東レ株式会社 | ３環性トリアゾロ誘導体の製造方法 |
| EP0726260A1 (en) | 1995-02-08 | 1996-08-14 | American Cyanamid Company | Herbicidal (1,2,4)thiadiazoles |
| UA56185C2 (uk) * | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування |
| WO2000043008A1 (en) | 1999-01-25 | 2000-07-27 | Smithkline Beecham Corporation | Anti-androgens and methods for treating disease |
| AP2001002281A0 (en) * | 1999-04-01 | 2001-09-30 | Pfizer Prod Inc | Sorbitol dehydrogen inhibitors. |
| CA2458009C (en) * | 2001-08-24 | 2011-08-16 | Yale University | Piperazinone compounds as anti-tumor and anti-cancer agents and methods of treatment |
| AU2003225916A1 (en) * | 2002-03-25 | 2003-10-13 | Merck & Co., Inc. | Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| ES2270143T3 (es) | 2002-08-07 | 2007-04-01 | Novartis Ag | Compuestos organicos como agentes para el tratamiento de condiciones mediadas por aldosterona. |
| MY139563A (en) | 2002-09-04 | 2009-10-30 | Bristol Myers Squibb Co | Heterocyclic aromatic compounds useful as growth hormone secretagogues |
| AR043443A1 (es) | 2003-03-07 | 2005-07-27 | Merck & Co Inc | Procedimiento de preparacion de tetrahidrotriazolopirazinas y productos intermedios |
| US20040214832A1 (en) * | 2003-04-10 | 2004-10-28 | Cuiman Cai | Piperazine derivative renin inhibitors |
| EP1670476A4 (en) * | 2003-09-30 | 2009-05-27 | Merck & Co Inc | ANTAGONISTS OF TACHYKININ RECEPTOR BASED ON PHENYL PYRROLIDINE ETHER |
| MY152888A (en) * | 2004-02-18 | 2014-11-28 | Astrazeneca Ab | Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists. |
| CN1934112A (zh) * | 2004-02-18 | 2007-03-21 | 阿斯利康(瑞典)有限公司 | 稠合的杂环化合物及其作为代谢型谷氨酸受体拮抗剂的应用 |
| GB0509405D0 (en) * | 2005-05-10 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
| WO2007081897A2 (en) * | 2006-01-11 | 2007-07-19 | Merck & Co., Inc. | Fused triazole tachykinin receptor antagonists |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| GB0610680D0 (en) | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| US7943617B2 (en) | 2006-11-27 | 2011-05-17 | Bristol-Myers Squibb Company | Heterobicyclic compounds useful as kinase inhibitors |
| JP5485148B2 (ja) | 2007-06-21 | 2014-05-07 | カラ セラピューティクス インコーポレイテッド | 置換イミダゾ複素環 |
| US8486948B2 (en) * | 2007-10-19 | 2013-07-16 | Boehringer Ingelheim International Gmbh | Piperazinodihydrothienopyrimidine derivatives |
| EP2225238B1 (en) | 2007-11-29 | 2014-09-03 | Boehringer Ingelheim International GmbH | Derivatives of 6,7-dihydro-5h-imidazoý1,2- ¨imidazole-3- carboxylic acid amides |
| PE20091093A1 (es) | 2007-12-03 | 2009-08-25 | Takeda Pharmaceutical | Compuesto heterociclico que contiene nitrogeno y su uso |
| US8329709B2 (en) | 2008-01-09 | 2012-12-11 | Genentech, Inc. | 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors |
| JP2011509962A (ja) | 2008-01-17 | 2011-03-31 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 置換スルホンアミド誘導体 |
| EP2085398A1 (en) * | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
| EP2090576A1 (en) | 2008-02-01 | 2009-08-19 | Merz Pharma GmbH & Co.KGaA | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators |
| US8501946B2 (en) * | 2009-04-29 | 2013-08-06 | Glaxo Group Limited | 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine derivatives as P2X7 modulators |
| GB0907515D0 (en) | 2009-04-30 | 2009-06-10 | Glaxo Group Ltd | Compounds |
| CN102482276A (zh) | 2009-07-13 | 2012-05-30 | 武田药品工业株式会社 | 杂环化合物及其用途 |
| PL2552920T3 (pl) * | 2010-04-02 | 2017-08-31 | Ogeda Sa | Nowe wybiórcze związki antagonistów receptora NK-3, farmaceutyczne kompozycje i sposoby do zastosowania w zaburzeniach pośredniczonych przez receptory NK-3 |
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| ES2572604T3 (es) | 2011-10-03 | 2016-06-01 | Euroscreen S.A. | Nuevas N-acil-5,6,7,(8-sustituido)-tetrahidro-[1,2,4]triazolo[4,3a]pirazinas quirales, como antagonistas selectivas del receptor de NK-3, composición farmacéutica y métodos para uso en trastornos mediados por el receptor de NK-3 |
| MX370000B (es) | 2013-03-29 | 2019-11-28 | Ogeda S A | Novedosas n-acil-(3-sustituidas)-(8-sustituidas)-5,6-dihidro-[1,2, 4]triazolo[4,3-a]piracinas como antagonistas selectivos del receptor de nk-3, composición farmacéutica y métodos para su uso en trastornos mediados por el receptor de nk-3. |
| EP2978766B1 (en) | 2013-03-29 | 2018-12-19 | Ogeda Sa | N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders |
| US9840508B2 (en) | 2013-03-29 | 2017-12-12 | Oged Sa | N-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a] pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders |
| EP3197876B1 (en) | 2014-09-25 | 2018-11-28 | Ogeda Sa | Novel chiral synthesis of n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines |
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