TWI262791B - 6-methoxy-2-naphthylacetic acid prodrugs - Google Patents

6-methoxy-2-naphthylacetic acid prodrugs

Info

Publication number
TWI262791B
TWI262791B TW089122555A TW89122555A TWI262791B TW I262791 B TWI262791 B TW I262791B TW 089122555 A TW089122555 A TW 089122555A TW 89122555 A TW89122555 A TW 89122555A TW I262791 B TWI262791 B TW I262791B
Authority
TW
Taiwan
Prior art keywords
methoxy
naphthylacetic acid
acid prodrugs
formula
composition
Prior art date
Application number
TW089122555A
Other languages
English (en)
Inventor
Nnochiri N Ekwuribe
Jennifer A Riggs
Original Assignee
Nobex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corp filed Critical Nobex Corp
Application granted granted Critical
Publication of TWI262791B publication Critical patent/TWI262791B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW089122555A 1999-10-27 2000-10-26 6-methoxy-2-naphthylacetic acid prodrugs TWI262791B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16186499P 1999-10-27 1999-10-27

Publications (1)

Publication Number Publication Date
TWI262791B true TWI262791B (en) 2006-10-01

Family

ID=22583099

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089122555A TWI262791B (en) 1999-10-27 2000-10-26 6-methoxy-2-naphthylacetic acid prodrugs

Country Status (20)

Country Link
US (3) US6525098B1 (zh)
EP (2) EP1223922A2 (zh)
JP (2) JP2003512425A (zh)
KR (2) KR20020043248A (zh)
CN (2) CN1413108A (zh)
AU (2) AU2919601A (zh)
BR (2) BR0015122A (zh)
CA (2) CA2387098A1 (zh)
CZ (2) CZ20021433A3 (zh)
HK (2) HK1048256A1 (zh)
HU (2) HUP0203321A2 (zh)
IL (2) IL149258A0 (zh)
MX (2) MXPA02004357A (zh)
NO (2) NO20022001L (zh)
NZ (2) NZ518554A (zh)
PL (2) PL354895A1 (zh)
RU (2) RU2002113657A (zh)
TW (1) TWI262791B (zh)
WO (2) WO2001030338A2 (zh)
ZA (2) ZA200203229B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI262791B (en) * 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US7163958B2 (en) * 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
CA2493156A1 (en) * 2002-07-29 2004-02-05 Nitromed, Inc. Cyclooxygenase-2 selective inhibitors, compositions and methods of use
US8062653B2 (en) 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
EP2398761A4 (en) * 2009-02-18 2015-11-04 Bezwada Biomedical Llc CONTROLLED RELEASE OF NITRIC OXIDE AND MEDICINES FROM FUNCTIONALIZED MACROMERS AND OLIGOMERS
CA2757480A1 (en) * 2009-04-02 2010-10-07 Allergan, Inc. Prostaglandin e receptor antagonists
CN101928227A (zh) * 2009-12-16 2010-12-29 天津工业大学 6-甲氧基-2-萘乙酸与水杨酰苯胺类化合物的互联体前药制备方法及应用

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Also Published As

Publication number Publication date
US6525098B1 (en) 2003-02-25
AU2919601A (en) 2001-05-08
HUP0203790A2 (hu) 2003-04-28
NO20022000L (no) 2002-06-27
NZ518554A (en) 2004-05-28
HU0203790D0 (en) 2002-12-28
BR0015121A (pt) 2002-07-02
EP1223926A2 (en) 2002-07-24
WO2001030334A3 (en) 2002-03-21
BR0015122A (pt) 2002-07-09
IL149258A0 (en) 2002-11-10
CN1413108A (zh) 2003-04-23
EP1223922A2 (en) 2002-07-24
IL149257A0 (en) 2002-11-10
ZA200203231B (en) 2003-07-23
NZ518553A (en) 2004-02-27
HK1048256A1 (zh) 2003-03-28
WO2001030334A2 (en) 2001-05-03
CZ20021435A3 (cs) 2002-08-14
US20030069309A1 (en) 2003-04-10
JP2003512424A (ja) 2003-04-02
KR20020043248A (ko) 2002-06-08
US20050054735A1 (en) 2005-03-10
WO2001030338A3 (en) 2002-01-31
ZA200203229B (en) 2003-07-23
CZ20021433A3 (cs) 2002-08-14
AU1576101A (en) 2001-05-08
NO20022001D0 (no) 2002-04-26
KR20020043249A (ko) 2002-06-08
HUP0203790A3 (en) 2003-05-28
JP2003512425A (ja) 2003-04-02
MXPA02004357A (es) 2002-11-07
NO20022001L (no) 2002-06-25
CA2389181A1 (en) 2001-05-03
CA2387098A1 (en) 2001-05-03
RU2002113661A (ru) 2004-01-10
CN1413106A (zh) 2003-04-23
PL354510A1 (en) 2004-01-26
RU2002113657A (ru) 2004-01-10
HUP0203321A2 (hu) 2003-02-28
WO2001030338A2 (en) 2001-05-03
HK1048257A1 (zh) 2003-03-28
WO2001030338A8 (en) 2002-11-21
MXPA02004355A (es) 2002-11-07
NO20022000D0 (no) 2002-04-26
PL354895A1 (en) 2004-03-22

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