HUP0203321A2 - (6-Metoxi-2-naftil)-ecetsav prodrug készítmények gyulladás kezelésére - Google Patents

(6-Metoxi-2-naftil)-ecetsav prodrug készítmények gyulladás kezelésére

Info

Publication number
HUP0203321A2
HUP0203321A2 HU0203321A HUP0203321A HUP0203321A2 HU P0203321 A2 HUP0203321 A2 HU P0203321A2 HU 0203321 A HU0203321 A HU 0203321A HU P0203321 A HUP0203321 A HU P0203321A HU P0203321 A2 HUP0203321 A2 HU P0203321A2
Authority
HU
Hungary
Prior art keywords
methoxy
treating inflammation
naphthylacetic acid
acid prodrugs
compositions
Prior art date
Application number
HU0203321A
Other languages
English (en)
Inventor
Nnochiri N. Ekwuribe
Jennifer A. Riggs
Original Assignee
Nobex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobex Corporation filed Critical Nobex Corporation
Publication of HUP0203321A2 publication Critical patent/HUP0203321A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgyát emberben gyulladás kezelésére alkalmazható,hatóanyagként egyik megvalósításban másik megvalósításban és másiktovábbi megvalósításban általános képletű vegyületet - ahol R vagy R<terápiás hatású csoportok - tartalmazó gyógyszerkészítmények képezik. Ó
HU0203321A 1999-10-27 2000-10-27 (6-Metoxi-2-naftil)-ecetsav prodrug készítmények gyulladás kezelésére HUP0203321A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16186499P 1999-10-27 1999-10-27
PCT/US2000/029757 WO2001030334A2 (en) 1999-10-27 2000-10-27 6-methoxy-2-naphthylacetic acid prodrugs compositions for treating inflammation

Publications (1)

Publication Number Publication Date
HUP0203321A2 true HUP0203321A2 (hu) 2003-02-28

Family

ID=22583099

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0203321A HUP0203321A2 (hu) 1999-10-27 2000-10-27 (6-Metoxi-2-naftil)-ecetsav prodrug készítmények gyulladás kezelésére
HU0203790A HUP0203790A3 (en) 1999-10-27 2000-10-27 Use of compositions containing 6-methoxy-2-naphthylacetic acid prodrugs for treating inflammation

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0203790A HUP0203790A3 (en) 1999-10-27 2000-10-27 Use of compositions containing 6-methoxy-2-naphthylacetic acid prodrugs for treating inflammation

Country Status (20)

Country Link
US (3) US6525098B1 (hu)
EP (2) EP1223926A2 (hu)
JP (2) JP2003512425A (hu)
KR (2) KR20020043249A (hu)
CN (2) CN1413108A (hu)
AU (2) AU2919601A (hu)
BR (2) BR0015121A (hu)
CA (2) CA2387098A1 (hu)
CZ (2) CZ20021435A3 (hu)
HK (2) HK1048256A1 (hu)
HU (2) HUP0203321A2 (hu)
IL (2) IL149257A0 (hu)
MX (2) MXPA02004355A (hu)
NO (2) NO20022001L (hu)
NZ (2) NZ518553A (hu)
PL (2) PL354895A1 (hu)
RU (2) RU2002113661A (hu)
TW (1) TWI262791B (hu)
WO (2) WO2001030338A2 (hu)
ZA (2) ZA200203229B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI262791B (en) * 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
WO2004004648A2 (en) * 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
EP1542972A4 (en) * 2002-07-29 2008-01-23 Nitromed Inc CYCLOOXYGENASE-2 SELECTIVE INHIBITORS, COMPOSITION AND METHOD OF USE
EP2398761A4 (en) * 2009-02-18 2015-11-04 Bezwada Biomedical Llc CONTROLLED RELEASE OF NITRIC OXIDE AND MEDICINES FROM FUNCTIONALIZED MACROMERS AND OLIGOMERS
US8062653B2 (en) 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
AU2010232556A1 (en) * 2009-04-02 2011-11-03 Allergan, Inc. Prostaglandin E receptor antagonists
CN101928227A (zh) * 2009-12-16 2010-12-29 天津工业大学 6-甲氧基-2-萘乙酸与水杨酰苯胺类化合物的互联体前药制备方法及应用

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4009197A (en) 1967-01-13 1977-02-22 Syntex Corporation 2-(6-Substituted-2'-naphthyl) acetic acid derivatives and the salts and esters thereof
US3904682A (en) 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
JPS5441587B1 (hu) * 1969-09-30 1979-12-08 Syntex Corp
DE2051012A1 (en) * 1970-10-17 1972-04-20 Syntex Corp., Panama 1,6-methano-(10)-annulenes - with anti-inflammatory analgesic antipyr hypocholesterolaemic and fibrinolytic activity
US3978116A (en) * 1971-11-04 1976-08-31 Syntex Corporation 2-naphthyl acetic acid derivatives and compositions and methods thereof
US3883662A (en) * 1973-03-29 1975-05-13 Syntex Corp Method for delaying the onset of, or postponing, parturition
US4327022A (en) 1973-08-16 1982-04-27 Sterling Drug Inc. Heterocyclic alkyl naphthols
US4061779A (en) 1973-09-11 1977-12-06 Beecham Group Limited Naphthalene derivatives having anti-inflammatory activity
US4420639C1 (en) 1973-09-11 2001-08-21 Beecham Group Ltd Aromatic compounds
DE2860631D1 (en) 1978-01-07 1981-05-07 Beecham Group Plc Process for the preparation of 4-(6-methoxy-2-naphthyl)butan-2-one and 2-acetyl-3-(6-methoxy-2-naphthyl) propenoic acid esters
US4246193A (en) 1979-11-26 1981-01-20 Syntex Corporation Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
CH641432A5 (de) 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.
US4268442A (en) 1978-11-14 1981-05-19 Sagami Chemical Research Center Process for preparing aromatic acetic acid
EP0011925B1 (en) * 1978-11-23 1982-09-22 Beecham Group Plc Naphthalene derivatives, a process for their preparation and their use in anti-inflammatory pharmaceutical compositions
IT1109200B (it) 1979-02-20 1985-12-16 Montedison Spa Processo per la preparazione di esteri di acidi arilacetici da alfa-alo-alchilarilchetoni
US4515811A (en) 1979-07-06 1985-05-07 Syntex Corporation Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid
IT1168387B (it) 1981-04-01 1987-05-20 Alfa Farmaceutici Spa Procedimento per la preparazione dell'acido 2-(6-metossi-2-naftil)-propionico
US4542237A (en) 1981-04-30 1985-09-17 Syntex Pharmaceuticals International Limited Manufacture of alpha-arylalkanoic acids and precursors
US4654438A (en) 1981-04-30 1987-03-31 Syntex Pharmaceuticals International Limited Manufacture of alpha-arylalkanoic acids and precursors
IT1190741B (it) 1982-03-22 1988-02-24 Blaschim Spa Procedimento per preparare esteri dell'acido 2-(6'-metossi-2'-naftil)-propionico
IT1210947B (it) 1982-11-03 1989-09-29 Zambon Spa Procedimento per preparare esteri di acidi arilalcanoici
US4723033A (en) 1982-11-24 1988-02-02 Syntex Pharmaceuticals International Ltd. Manufacture of optically active α-arylalkanoic acids and precursors thereof
IL67445A (en) 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
IT1164319B (it) 1983-07-27 1987-04-08 Blaschim Spa Procedimento per la risoluzione dell'acido (+-)2-(6'-metossi-2'-naftil)-propionico
JPS6081145A (ja) 1983-10-11 1985-05-09 Nissan Chem Ind Ltd ｄ−α−（６−メトキシ−２−ナフチル）プロピオン酸エステルのアルカリ性加水分解による，ｄ−α−（６−メトキシ−２−ナフチル）プロピオン酸の製法
US4661525A (en) 1984-03-28 1987-04-28 Texaco Inc. Process for producing lower aliphatic alcohols
GB8416638D0 (en) 1984-06-29 1984-08-01 Beecham Group Plc Topical treatment and composition
US4608441A (en) 1984-07-11 1986-08-26 Blaschim S.P.A. Process for the preparation of arylalkanoic acids by oxidative rearrangement of arylalkanones
US4670586A (en) 1984-09-12 1987-06-02 Nippon Chemicals Co., Ltd. Method for the production of α-aryl-alkanoic acid
DE3584754D1 (de) 1984-09-24 1992-01-09 Nobel Chemicals Ab Verfahren zur herstellung von arylalkylketonen.
IT1183626B (it) 1985-05-14 1987-10-22 Vamp Srl Prodotti polimerici autoestinguenti a base di poliolefine
IT1201443B (it) 1985-07-31 1989-02-02 Zambon Spa Intermedi per la sintesi di acidi carbossilici
JPH064561B2 (ja) 1986-02-08 1994-01-19 日本石油化学株式会社 （置換アリ−ル）カルボン酸の製造方法
CA1286316C (en) 1986-02-08 1991-07-16 Isoo Shimizu Method for refining 2-(aryl substituted)-propionic acid or its salt
IT1197800B (it) 1986-08-01 1988-12-06 Zambon Spa Processo per la sintesi di acidi carbossilici
IT1198234B (it) 1986-12-23 1988-12-21 Zambon Spa Processo stereoconvergente per la preparazione di acidi carbossilici otticamente attivi
US5202495A (en) 1987-03-26 1993-04-13 Callander Sidney E Chemical process
IT1222013B (it) 1987-07-10 1990-08-31 Chimica Profarmaco Spa Ind Processo di risoluzione ottica di acido 2 (6 metossi 2 naftil) propionico
US5225603A (en) 1987-07-14 1993-07-06 Hoechst Celanese Corporation Preparation of 4-(6'-methoxy-2'-naphthyl)-3-buten-2-one
JP2518014B2 (ja) 1988-05-31 1996-07-24 日産化学工業株式会社 α−置換酢酸の精製方法
GB8915104D0 (en) 1989-06-30 1989-08-23 Beecham Group Plc Chemical process
NL9001703A (nl) 1990-07-27 1992-02-17 Westspur Investment Ltd Werkwijze voor de bereiding van s(+)-6-methoxy-alfa-methyl-2-naftaleen-azijnzuur.
US5179208A (en) 1990-10-19 1993-01-12 Korea Institute Of Science And Technology Process for preparing d-2-(6-methoxy-2-naphthyl)-propionic acid and intermediate thereof
KR930003864B1 (ko) 1990-10-19 1993-05-14 한국과학기술연구원 d-2-(6-메톡시-2-나프틸)-프로피온산의 제조방법
ATE137494T1 (de) 1991-07-31 1996-05-15 Tessenderlo Chem Nv Verfahren zur alpha-monoalkierung von arylacetonitrilen, arylacetoestern und arylessigsäuren
US5248815A (en) 1991-12-27 1993-09-28 Paradies Henrich H Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
GB9201857D0 (en) 1992-01-29 1992-03-18 Smithkline Beecham Plc Novel compound
FR2686876B1 (fr) 1992-02-04 1994-05-13 Hoechst Ste Francaise Procede de preparation d'acides arylacetiques et de leurs sels de metaux alcalins.
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5223640A (en) 1992-12-23 1993-06-29 Hoechst Celanese Corporation Preparation of optically active α-aryl propionic acids
GB9314693D0 (en) 1993-07-15 1993-08-25 Smithkline Beecham Plc Naphthyl derivatives for treatment method
WO1995009831A1 (en) 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
CA2190087C (en) 1994-05-10 2005-08-02 Piero Del Soldato Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities
US5426243A (en) 1994-08-17 1995-06-20 Albemarle Corporation Process for preparing 1,6-dibromo-2-naphthylene compounds
US5703073A (en) 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
US5600009A (en) 1996-04-09 1997-02-04 Hoechst Celanese Corporation Use of 4-substituted 2-butanones to prepare nabumetone
WO1997019048A1 (en) 1995-11-17 1997-05-29 Aeci Limited Synthesis of propionic acid derivatives
IT1285567B1 (it) 1996-02-21 1998-06-18 Alfa Chem Ital Nuovo processo per la sintesi del nabumetone
IT1282686B1 (it) 1996-02-26 1998-03-31 Nicox Sa Composti in grado di ridurre la tossicita' da farmaci
IT1283638B1 (it) 1996-07-29 1998-04-23 Archimica Spa Procedimento per la preparazione di un naftilbutanone
US5756851A (en) 1996-10-21 1998-05-26 Albemarle Corporation Production of nabumetone or precursors thereof
US5792886A (en) 1997-01-08 1998-08-11 Albemarle Corporation Production of racemic 2-(6-methoxy-2-naphthyl) propionic acid of precursors thereof
WO1998037070A1 (fr) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Composes a anneaux condenses, leur procede de production et leur utilisation
US5741938A (en) 1997-02-21 1998-04-21 Albemarle Corporation Production of alkyl aralkyl keones from allylic-aralkenyl secondary alcohols
US5847225A (en) 1997-04-25 1998-12-08 Albemarle Corporation Production of naphthyl-substituted ketones from naphthaldehydes
IT1291284B1 (it) 1997-04-30 1999-01-07 Secifarma Spa Processo per la preparazione del 4-(6'-metossi-2'-naftil)butan-2-one (nabumetone).
US5861538A (en) 1997-08-04 1999-01-19 Albemarle Corporation Production of alkoxynaphthyl-substituted ketones from naphthaldehydes
US5874614A (en) 1997-12-11 1999-02-23 Albemarle Corporation Sodium (S)-2-(6-methoxy-2-naphthyl)propionate monohydrate
US6436990B1 (en) * 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
TWI262791B (en) * 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US6552078B2 (en) * 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs

Also Published As

Publication number Publication date
NO20022000D0 (no) 2002-04-26
EP1223922A2 (en) 2002-07-24
RU2002113661A (ru) 2004-01-10
PL354510A1 (en) 2004-01-26
NO20022001D0 (no) 2002-04-26
WO2001030338A8 (en) 2002-11-21
ZA200203231B (en) 2003-07-23
NZ518553A (en) 2004-02-27
HK1048257A1 (zh) 2003-03-28
HUP0203790A2 (hu) 2003-04-28
IL149258A0 (en) 2002-11-10
WO2001030338A2 (en) 2001-05-03
US20030069309A1 (en) 2003-04-10
TWI262791B (en) 2006-10-01
HK1048256A1 (zh) 2003-03-28
HU0203790D0 (en) 2002-12-28
NZ518554A (en) 2004-05-28
IL149257A0 (en) 2002-11-10
US6525098B1 (en) 2003-02-25
US20050054735A1 (en) 2005-03-10
WO2001030334A2 (en) 2001-05-03
AU1576101A (en) 2001-05-08
RU2002113657A (ru) 2004-01-10
CZ20021433A3 (cs) 2002-08-14
WO2001030334A3 (en) 2002-03-21
MXPA02004355A (es) 2002-11-07
NO20022001L (no) 2002-06-25
CN1413106A (zh) 2003-04-23
CN1413108A (zh) 2003-04-23
JP2003512425A (ja) 2003-04-02
KR20020043249A (ko) 2002-06-08
CA2387098A1 (en) 2001-05-03
MXPA02004357A (es) 2002-11-07
PL354895A1 (en) 2004-03-22
WO2001030338A3 (en) 2002-01-31
JP2003512424A (ja) 2003-04-02
AU2919601A (en) 2001-05-08
CA2389181A1 (en) 2001-05-03
HUP0203790A3 (en) 2003-05-28
EP1223926A2 (en) 2002-07-24
BR0015121A (pt) 2002-07-02
ZA200203229B (en) 2003-07-23
KR20020043248A (ko) 2002-06-08
CZ20021435A3 (cs) 2002-08-14
BR0015122A (pt) 2002-07-09
NO20022000L (no) 2002-06-27

Similar Documents

Publication Publication Date Title
ES2145913T3 (es) Inhibidores de metaloproteasas.
AU2003297260A1 (en) Fast-disintegrating solid dosage forms being not friable and comprising pullulan
DE69930259D1 (de) Zusammensetzungen zur anwendung von entzündungshemmenden, insbesondere antiseptischen und/oder wundheilenden wirkstoffen im oberen atemwegtrakt und/oder ohr
HK1080459A1 (en) Novel pyrimidineamide derivatives and the use thereof
HUP0203590A2 (hu) Gyógyszerkészítmény a csonttömeg csökkenésével járó betegségek kezelésére
PT705100E (pt) Guanidinas substituidas terapeuticas
HUP9904092A2 (hu) Gyógyszerkészítmény HIV és rák kezelésére valamint eljárás előállítására
SE0300831D0 (sv) New formulations and use therof
HUP0101710A2 (hu) Mátrix-protein kompozíciók sebgyógyulás elősegítésére
SE9704644D0 (sv) New use
HUP0203321A2 (hu) (6-Metoxi-2-naftil)-ecetsav prodrug készítmények gyulladás kezelésére
EP1626731A4 (en) ANTI-INFLAMMATORY MEDICINE PREPARATIONS FOR INFLAMMATORY INFLAMMATION AND THE THERAPY OR PROPHYLAXIS OF GASTRIC TOXICITY
HUP0204208A2 (hu) Pruritus kezelésére szolgáló külsőleges gyógyszerkészítmény
WO2002096870A3 (en) Sponge-derived terpenoids and methods of use
DK0561882T3 (da) Hydroxamsyrederivater, som inhiberer lipoxygenase
HUP0204180A2 (hu) Külsőleges készítmény és alkalmazása allergiás dermatitisz kezelésére
HUP0402645A2 (hu) Egy glitazont és egy 4-oxobutánsavat tartalmazó gyógyászati készítmény és ennek alkalmazása cukorbetegség kezelésére
MXPA04006269A (es) Composicion farmaceutica que comprende un inhibidor de alfa-glucosidasa y acido 4-oxobutanoico y uso de la misma para tratamiento de diabetes.
UA30143C2 (uk) Лікувальний препарат для профілактики та лікування інфекційних та запальних захворювань
JO2370B1 (en) Pharmaceutical formulations for the treatment of painful, inflamed and ulcerated conditions of wet epithelial surfaces such as mucositis, stomatitis and Behçet syndrome