TWI237058B - Biosynthetic genes for Spinosyn insecticide production - Google Patents

Biosynthetic genes for Spinosyn insecticide production Download PDF

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TWI237058B
TWI237058B TW088103537A TW88103537A TWI237058B TW I237058 B TWI237058 B TW I237058B TW 088103537 A TW088103537 A TW 088103537A TW 88103537 A TW88103537 A TW 88103537A TW I237058 B TWI237058 B TW I237058B
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Richard H Baltz
M Christine Broughton
Kathryn P Crawford
Krishnamurthy Madduri
Donald J Merlo
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Dow Agrosciences Llc
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Description

1237058 五、發明説明（i) 本發明提供新穎的生物合成基因，併入有生物合成 基因的載體，被該生物合成基因所轉形的史賓多泡酵母菌 菌株，使用這些基因來增加 史賓諾辛殺蟲劑大環内酯物之生產的方法，以及使用這些 基因或其片段來改變生產史賓諾辛的史賓多泡酵母菌菌株 所生產的產物的方法。 訂 如美國專利案件第5,362,634號所揭示的，發酵產物 A83543是由史賓多泡酵母菌得到的一類相關化合物。這 一類已知的成員被稱為因子或組份，而各被給予一個字母 命名指認。這些化合物此後稱之為史賓諾辛A、B等等。 這些史賓諾辛化合物可用於控制蛛形綱動物，線蟲類和昆 蟲類，尤其是鱗翅類蝶蛾和雙翅類，它們都是對環境友善 的’已有毒理學的資料。表1和表2確認各種已知史賓諾辛 化合物的構造： 表1
A7 1237058 __B7 五、發明説明（2) 經濟部智慧財產局員工消費合作社印製 因子 R1’ R2， R3， R4， R5， R6， R7， 史賓諾辛A Η ch3 (a) C2H5 ch3 ch3 ch3 史賓諾辛B Η ch3 (b) c2h5 ch3 ch3 ch3 史賓諾辛c Η ch3 (c) c2h5 ch3 ch3 ch3 史賓諾辛D ch3 ch3 (a) c2h5 ch3 ch3 ch3 史賓諾辛E Η ch3 (a) ch3 ch3 ch3 ch3 史賓諾辛F Η H (a) c2h5 ch3 ch3 ch3 史賓諾辛G Η ch3 XCH, (d) c2h5 ch3 ch3 ch3 史賓諾辛Η Η ch3 (a) c2h5 H ch3 ch3 史賓諾辛J Η ch3 (a) c2h5 ch3 H ch3 史賓諾辛Κ Η ch3 ⑷ c2h5 ch3 ch3 H 史賓諾辛L ch3 ch3 ⑷ c2h5 ch3 H ch3 史賓諾辛Μ Η ch3 (b) c2h5 ch3 H ch3 史賓諾辛Ν ch3 ch3 (b) c2h5 ch3 H ch3 史賓諾辛〇 ch3 ch3 ⑷ c2h5 ch3 ch3 H 史賓諾辛Ρ Η ch3 ⑷ c2h5 ch3 H H 史賓諾辛Q ch3 ch3 (a) c2h5 H ch3 ch3 史賓諾辛R Η ch3 (b) c2h5 H ch3 ch3 史賓諾辛S Η ch3 (a) ch3 H ch3 ch3 史賓諾辛Τ Η ch3 (a) c2h5 H H ch3 史賓諾辛U Η ch3 (a) c2h5 H ch3 H 史賓諾辛V ch3 ch3 (a) c2h5 H ch3 H 史賓諾辛W ch3 ch3 (a) c2h5 ch3 H H 史賓諾辛Υ Η ch3 (a) ch3 ch3 ch3 H 史賓諾辛A17-Psa Η ch3 H c2h5 ch3 ch3 ch3 史賓諾辛D17-Psa ch3 ch3 H c2h5 ch3 ch3 ch3 史賓諾辛E17-Psa Η ch3 H ch3 ch3 ch3 ch3 史賓諾辛F17-Psa Η H H c2h5 ch3 ch3 ch3 史賓諾辛H17_Psa Η ch3 H c2h5 H ch3 ch3 史賓諾辛n7-Psa Η ch3 H c2h5 ch3 H ch3 史賓諾辛L17-Psa ch3 ch3 H c2h5 ch3 H ch3 m. I— if I SI -- -- - flu 士n (請先閲讀背面之注意事項再填寫本頁) 訂 線 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（3) 表2OR3· •m|〇r5?
因子 R1， R2’ R3， R4’ R5’ 史賓諾辛A9-Psa Η ch3 (a) C2H5 H 史賓諾辛D9-Psa ch3 ch3 (a) c2h5 H 史賓諾辛A配質 Η ch3 H c2h5 H 史賓諾辛D配質 ch3 ch3 H c2h5 H (請先閱讀背面之注意事項再填寫本頁) -^^1.
、1T 天然得到的史賓諾辛化合物由5,6,5-三環系統組成， 并合一個12-員大環内酯，一個中性糖（鼠李糖）和一個胺 基糖（forosamine)(參考Kirst等人的文獻（1991)。如果沒有 胺基糠，此化合物稱為准配質A、D等等，如果沒有中性 糖，則稱為反准配質A、D等等。更好的命名法是將准配 質稱為史賓諾辛A17-Psa、史賓諾辛D17-Psa等等，而將反 准配質稱為史賓諾辛A9-Psa、史賓諾辛D9-Psa等等。 天然得到的史賓諾辛化合物可由NRRL 18395、 18537 、 18538 、 18539 > 18719 、 18720 、 18743和18823培 養發酵而得。這些培養儲存於，並為Midwest Area Northern Regional Reseach Center，Agricultural Research Service， ___-0J；_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 線 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（4)
United States Department of Agriculture, 1815 North University Street，Peoria，IL 61604收集貯備培養之一部 份。 美國專利案件第5,362,634號和相對的歐洲專利申請 案件第375316 A1號揭示史賓諾辛A、B、C、D、E、F、G、 Η和J。其中揭示這些化合物為擇自NRRL 18395、NRL 18537、NRRL 1 8538和NRRL 18539等新穎微生物史賓多 泡酵母菌的菌株培養而得到。 ^¥〇93/09126揭示史賓諾辛1^、^1、1^、（5、11、3和丁。 該文也揭示兩種生產史賓諾辛J的菌株·· NRRL 18719和 NRRL 18720，和一種生產史賓諾辛Q、R、S和T的菌株： NRRL 18823。 ^^〇94/20518和1^5,6704,486揭示史賓諾辛〖、〇、？、 U、V、W和Y，及此等之衍生物。也揭示生產史賓諾辛K 的菌株，NRRL 18743。 生產史賓諾辛化合物的難題是，需要用很大的發酵 體積，而只得到很小量的史賓諾辛。因此極需要增加史賓 諾辛的生產效率，降低成本，增加史賓諾辛實用性。一個 含有史賓諾辛生物合成酵素基因的選殖的DN A片段，可 以使編碼生產史賓諾辛速率限制酵素的基因複製。在任何 編碼的活性之一限制所要的史賓諾辛合成時，它可用來增 加收率。可由複製編碼將macrocin轉形成泰樂黴素的甲基 轉移酶速率限制的基因的發酵，得到 此形態的增加收率（Baltz等人，1997)。另一個例子 _^_士_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 Φ! 經濟部智慧財產局員工消費合作社印製 [237058 五、 發明説明（ A7 B7 w097/_6中顯示，將^ __染色體的非必要區 —第—個ery G’會增加6脫氧紅黴素D的轉形為6“2_ 二脫氧紅黴素A。 選殖的生物合成基因也提供_種生產史賓諾辛新衍 生物的方法，該何生物具有不同的殺蟲劑活性範圍。新的 衍生物是需要的，因為，雖然已知的史賓諾辛有寬廣的抑 制昆蟲圖I#，但它們不會抑制所有的家禽。史賓諾辛生物 合成的中間產物，或它們體内產生的衍生物，或它們的體 外化學修飾的衍生物可能提供不同的抑制範圍。特定的中 間產物（或其天然衍生物）可由史賓多泡酵母菌變異種菌株 合成，該菌株的一些編碼史賓諾辛生物合成酵素的基因已 被破壞。這些菌株，可由含有目標基因内部片段的變異種 質體，經過同系重組同化作用而產生。在質體同化之後， 形成二個不完全的生物合成基因複製品，而沒有編碼的酵 素功此。此酵素的受質或其天然的衍生物，在變異種菌株 發酵後會聚集。這種作法可用來有效地得到生產新穎的6_ 脫氧紅黴素衍生物（Weber & McAlpine，1992)的 Saccharopolyspora erythraea镜橡。 史賓多泡酵母菌變異種菌株也可以合成新穎的中間 產物，該菌株編碼史賓諾辛生物合成酵素的某些基因的一 部份’以體外特定變異種的相同基因的一部份，或以其他 生物體基因的相關部份置換。含有非變異種序列新片段間 的保護目標區域的變異種質體，經由雙重同系重組，交換 目標區域，可以得到這些函株。此雜交基因會產生不同功 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） ---------V---I (請先閲讀背面之注意事項再填寫本頁) 、·ιτ 線 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（6) (請先閲讀背面之注意事項再填寫本頁) 能的蛋白質，缺少活性或進行新的酵素轉形。變異種菌株 發酵時會聚集新的衍生物。這種方法曾用來得到一種 Saccharopolyspora er少i/zaea菌株，該菌株可製造一種新 穎的無水紅黴素衍生物（Donadio等人，1993)。本發明核 酸可用於生產設計的聚烯酮合成酶，這種形態的合成酶揭 示於^^0 93/13663和1^ 5,824,513，用於生產揭示於，0 98/01546，W098/49315，和 W098/51695形態的雜交聚烯 酮合成酶，和用於建立聚烯酮合成酶存庫和聚烯酮存庫， 這些說明於WO 96/40968、W098/49315、WO 98/27203、 US 5,783,431、US 5,824,485和 US 5,811，238 ° -線· 經濟部智慧財產局員工消費合作社印製 史賓諾辛的生物合成步驟是，縮合和修飾2-及3-碳羧 酸前驅物，得到線型聚烯酮，環化並架橋化得到四環配質。 接著形成准配質（含有三-〇-曱基化鼠李糖），然後加入二-N-曱基化forosamine，完成生物合成（Broughton等人， 1991)。用類似的方法可合成其他的大環内酯物，如抗生 素紅黴素，抗寄生蟲劑avermectin和免疫抑制劑 rapamycin。以細菌生產這些化合物時，大部份的大環内 酯物生物合成的基因聚集於基因的70-80kb區域（Donadio 等人，1991 ; MacNeil等人，1992 ; Schwecke等人，1995)。 在這些基因群的中心是3-5個高度保留的基因，該基因編 碼很大的，多功能蛋白質的I型聚烯酮合成酶（PKS)。與聚 腈形成包含一個起始模組和數個延伸模組的錯合物，各在 漸長的聚烯酮鏈加入一個特定的乙醯基-CoA前驅物，以 特定的方式修飾β-酮基。然後以PKS模組中的組份和次序 _^_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 [237058 五、發明説明（ 決定該聚烯酮的構造。一個模組包含有數個區域，每一個 區域進行一個特定的功能。起始模組有一個乙醯轉移酶 (AT)區域，從前驅物加入一個乙醯基到乙醯基載劑蛋白質 (ACP)區域。延伸模組含有這些區域，與卜酮合成酶（ks) 區域，用脫羧縮合方式將預存的聚烯_鏈加入新的乙醯基 -ACP。延伸模組中也可以有另外的區域，進行特定的β_ 酮修飾：β-酮還原酶（KR)區域還原β__基成為羥基，脫水 酶（DH)區域移去經基得到雙鍵，而稀醇還原酶（ER)區域 還原雙鍵得到飽和碳。最後的延伸模組以硫酯酶（TE)區域 終結，該區域從PKS酵素以大環内酯的形式移去聚烯酮。 大環内酯物衍生自大環内酯的加成修飾，如甲基化 和還原態的改變，和加入不尋常糖。大多數需要這種修飾， 合成和接上糖類的基因聚集在PKS基因周圍。編碼脫氧糖 類生物合成酵素的基因與產生大環内酯物抗生素，如紅黴 素和泰樂黴素（Donadio等人，1993 ; Merson_Davies和 Cundliffe，1994)，和產生細胞外多醣者，如㈣狀//β和 FerwWa 0-抗原（Jiang 等人，1991 ; Kessler 等人，1993) 是相同的。所有這些合成包括核苷酸二鱗酸酯之加入來活 化葡萄糖，再經過脫水反應，還原及/或表異構化。得到 的糖類經過一次或更多次的修飾，如脫氧，胺交換和甲基 化，依照大環内酯物内糖類部份的形式而定。糖類以特定 的糖基轉移酶的作用加入大環内酯物。參與合成和加入糖 類的基因可能緊密聚集的-甚至轉寫為一個簡單的作用子-或可能是分散的（Decker & Hutchinson，1993 ; Jarvis及 -10- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X；297公釐） I— m - it. - m n —ϋ I (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 λτ _____Β7 五、發明説明（8)
Hutchinson，1994)。史賓諾辛的合成也包括内酯核的架 橋，這是在生產大環内酯物者少有的活性。因此，史賓諾 辛生物合成群可能是僅有的多含有一個編碼此功能酵素的 基因者。 下面的名詞以下面定義在此使用：
AmR —賦予抗阿布拉黴素性能之基因。
ApR—賦予抗氨甲苯青黴素性能之基因。 ACP —乙醯基載體蛋白質。 AT—乙醯基轉移酶。 bp —氮驗基對。 選殖--個DNA片段加入重組型DNA選殖載體，並 以重組型DNA轉形宿主細胞的方法。
Cm—賦予抗綠黴素性能基因。 編碼傾向一以特別的密碼子指定一個特定胺基酸的 傾向。在史賓多泡酵母菌的情況，此傾向是以含有胞嘧淀 或鳥嘌呤的密碼子作為第三氮鹼基。 經濟部智慧財產局員工消費合作社印製 互補作用一以選殖基因將變異種菌株回復成為正常 的外表型。 結合作用一遺傳物質由細菌細胞移轉到另一個細胞 的方法。 cos — λ結合終端序列。 粘接質體一重組型DNA選殖載體，該載體是不僅可 以以質體相同的方法在宿主細胞複製，也可以包裝入噬菌 體頭質體。 _；____-11 - _ 本紙張尺度適财國國家縣（〇^)》4祕（21(^297公釐） ' 一^ 237058
發明説明（ DH—脫水酶。 ER —婦醇還原酶。 外結合物一結合配對衍生的重組型菌株。 基因一編碼聚肷之DNA序列。 基因存庫--組重組型DNA選殖載體，其中選殖有 特殊生物體内代表實質所有DNA序列之DNA片段。 相似性一序列之間的類似程度。 雜交作用一二單股DNA分子纏繞成為雙股DNA分子 的方法’可以是或不是完全氮驗基配對。 活體外包裝一DNA至包覆蛋白質内之活體外包裝， 得到似病毒顆粒，可用感染方法將DN A引入宿主細胞。 kb —千個氮驗基對。 KR— β-酮還原酶。 KS —酮合成酶。 變異發生一產生DNA序列改變。可以是無規的或有 目標的，在體内或體外產生。變異可以是緘默的，或可造 成轉譯產物胺基酸序列改變的，改變蛋白質性質，得到變 異種外表型。
NmR—賦予抗新黴素性能之基因。 ORF —開放閱讀架構。 〇ri—複製（oriR)或移轉（oriT)質體起點。 PKS-聚稀酮合成酶。 啟動子一指引轉譯啟動之DNA序列。 重組型DNA選殖載體一任何獨立的複製劑或同化 -12- 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) ^^1. -訂 經濟部智慧財產局員工消費合作社印製 1237058
劑，包括但不限於質體，其中包含可以或已經加入一個或 更多個額外的DNA分子的DNA分子。 重組型DNA方法一用於產生、定性和修*DNA片段 選殖於重組型DNA載體的技術。 限制片段--個或更多個限制酵素作用產生的任何 線型DNA分子。 史賓諾辛—發酵產物，一般的特點是一個5,6,5-三環 系統，并合一個12-員大環内酯，中性的糖（鼠李糖）和胺 基糖類（forosamine)，或微生物利用所有的或大部份的史 賓諾辛基因得到的類似大環内酯發酵產物。 史負諸辛基因一編碼史賓諾辛生物合成需要產物的 DNA序列’特別是如後面說明的基因印以、印以、、 spnD、spnE、SpnF、spnG、spnH、spnl、spnJ、spnK、spnL、 spnM、spnN、spnO、spnP、spnQ、spnR、spnS、史賓多 泡酵母菌、史賓多泡酵母菌、史賓多泡酵母菌印卜 和史賓多泡酵母菌虹e，或此等之功能相當物。 次選殖株--個選殖載體，其含有以另一個相同體 積或更大的DNA衍生的嵌入DNA。 TE —硫酯酶。 轉形作用一DNA引入（異相或均相）接受宿主細胞，改 變基因形式，而使得接受細胞改變的作用。 圖式之簡要說明 第1圖為說明史賓諾辛生物合成途徑之圖示。 第2圖為說明BamHI片段和開放閱讀架構在史賓多泡 -_ -13- 本紙張尺度適用中國國家標準（CNS ) ( 210X297公釐） -ml- ml 1-^1 m n.^ n m m n (請先閲讀背面之注意事項再填寫本頁) 訂 線 經濟部智慧財產局員工消費合作社印製 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（ii 酵母菌DNA選殖區域之排列圖譜。 第3圖為粘接質體p〇J43 6之限制位和功能圖譜。 第4圖為粘接質體p〇J260之限制位和功能圖譜。 第5圖為pDAB 1523之限制位和功能圖譜。 發明之簡要說明 選殖史賓諾辛生物合成基因和相對的ORF，測定各 DNA序列。此後將選殖的基因和ORF稱為、印/2万、 spnC、spnD、spnE、spnF、spnG、spnH、spnl、spnJ、spnK、 spnL、spnM、spnN、spnO、spnP、spnQ、spnR、spnS、0ΚΈ1Λ5、 0RFL16、0RFR1、0RFR2、史賓多泡酵母菌ga、賓多泡 酵母菌、賓多泡酵母菌和史賓多泡酵母菌。第1 圖和後面的討論確認史賓諾辛生物合成中選殖基因預測的 功能。 在一方面，本發明提供一種分離的DNA分子，其包 含有一個編碼史賓諾辛生物合成酵素之DNA序列，其中 該酵素係為一個擇自於序列辨識編號：2-5、7-24、26、27、 29、33之組群中的胺基酸序列所定義；或該酵素係為一個 擇自於序列辨識編號：2-5、7-24、26、27、29、33之組 群中的胺基酸序列所定義，該胺基酸序列中被弄入一個或 更多個不會影響該酵素的功能性質之胺基酸取代。在一個 較佳的實施例中，該DNA序列是擇自於印dspAzC、 spnD、spnE、spnF、spnG、spnH、spnl、spnJ、spnK、spnL、 spnM、spnN、spnO、spnP、spnQ、spnR、spnS、0ΚΈΙΛ5、 0RFL16 、 0RFR1 、 0RFR2 、 史賓多泡酵母菌 ________ ___ιΐίζ_ 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公董1 (請先閲讀背面之注意事項再填寫本頁) P. 訂 -線 1237058 A7 B7 五、發明説明（j (Saccharopolyspora spinosa) gtt、史賓多他铸母議 gdh、 史賓多泡酵母菌叩/和史賓多泡酵母菌所組成之基因群組 中，該基因被載述於下列的氮鹼基：序列辨識編號：1之 氮鹼基21 1 11-28898、28916-35374、35419-44931、44966-59752 、 59803-76569 、 20168-20995 、 18541-19713 、 17749-185(Π、16556-17743、14799-16418、13592-14785、 12696-13547 、 11530-12492 、 10436-11434 、 8967-10427 、 7083-8450、5363-6751、4168-5325、3416-4165、2024-2791、 1 135-1971、76932-77528 和 77729-79984，序列辨識編號： 27之氮鹼基334-1 1 19、序列辨識編號：24之氮鹼基88- 1077，序列辨識編號：31之氮鹼基226-834，以及序列辨 識編號：24之氮鹼基1165-1992。 另一方面，本發明提供一個分離的DNA分子，其包 含有一個編碼史賓諾辛PKS區域之DNA序列，該區域係擇 自於 Ksi、Ati、ACPi、KS1、ATI、KR1 和 ACPI，此等分 別對應於序列辨識編號：2的胺基酸序列6-423、528-853、 895-977、998-1413、1525-1858、2158-2337和2432-2513 ° 在一個較佳的實施例中，該DNA序列是擇自於序列辨識 編號：1之氮鹼基 21126-22379、22692-23669、23793- 24041 、 24102-25349 、 25683-26684 、 27582-28121 和 28404-28649所組成之群組中。 另一方面，本發明提供一個分離的DNA分子，其包 含有一個編碼史賓諾辛PKS區域的DNA序列，該區域係擇 自於KS2、AT2、DH2、ER2、KR2和ACP2，該等區域分 _·__- 15-_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐] (請先閲讀背面之注意事項再填寫本頁) 訂 線 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（j 別被敘述於序列辨識編號：3之胺基酸序列1-424、536-866 、 892-1077 、 1338-1683 、 1687-1866和 1955-2034 。在 一個較佳的實施例中，該DNA序列是擇自於序列辨識編 號·· 1之氮鹼基29024-30295、30629-31621、31697-32254、 33035-34072、34082-34621、34886-35125 所組成之群組 中 〇 另一方面，本發明提供一個分離的DNA分子，其包 含有一個編碼史賓諾辛PKS區域之DNA序列，該區域係擇 自於 KS3、AT3、KR3、ACP3、KS4、AT4、KR4和 ACP4， 該等區域分別被敘述於序列辨識編號：4之胺基酸序列1-423 、 531-280 、 1159-1337 、 1425-1506 、 1529-1952 、 2066-2396、2700-2880和 2972-3053。在一個較佳的實施 例中，該DNA序列是擇自於序列辨識編號：1之氮鹼基 35518-36786、37108-38097、38992-39528、39790-40035、 40102-41373 、 41713-42705 、 43615-44157和 44431-44676 所組成之群組中。 另一方面，本發明提供一個分離的DNA分子，其包 含有一個編碼史賓諾辛PKS區域的DNA序列，該區域係擇 自於KS5、AT5、DH5、KR5、ACP5、KS6、AT6、KR6、 ACP6、KS7、AT7、KR7和ACP7，該等區域分別被敘述 於序列辨識編號·· 5的胺基酸序列1-424、539-866、893- 1078 、 1384-1565 、 1645-1726 、 1748-2172 、 2283-2613 、 2916-3095、3188-3269、3291-3713、3825-4153、4344-463 8 和4725_4806。在一個較佳的實施例中，該DNA序列是擇 -16 - _ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）~一 — "" (請先閲讀背面之注意事項再填寫本頁) 訂 線 經濟部智慧財產局員工消費合作社印製 A7 1237058 _________B7____ 五、發明説明（ 自於序列辨識編號：1之氮鹼基45077-46348、46691-47674 、 47753-48310 、 49226-49771 、 50009-50254 、 50318-51592、51923-52915、53822-54361、54638-54883、 54947-56215 、 56549-57535 、 58106-58990和 59249-59494 所組成之群組中。 另一方面，本發明提供一個的分離DNA分子，其包 含有一個編碼史賓諾辛PKS區域的DNA序列，該區域係擇 自於 KS8、AT8、DH8、KR8、ACP8、KS9、AT9、DH9、 KR9、ACP9、KS10、AT10、DH10、KR10、ACP10和 TE10， 該等區域分別被敘述於序列辨識編號：6之胺基酸序列1-424 - 530-848 - 883-1070 > 1369-1552 - 1648-1726 - 1749-2173 、 2287-2614 、 2640-2800 、 3157-3341 、 3422-3500 、 3534-3948、4060-4390、4413-4597、4900-5078、5172-5253 和5302-5555。在一個較佳的實施例中，該DNA序列是擇 自於序列辨識編號：1之氮鹼基59902-61 173、61489-62445 、 62548-63111 、 64006-64557 、 64843-65079 、 65146-66420、66760-67743、67819-683(Π、69370-69924、 70165-70401 - 70471-71745 > 72079-73071 ^ 73138-73692 > 74599_75135、75415-75660 和 75805-76566所組成之群組 中〇 另一方面，本發明提供一種分離的DNA分子，其包 含有一個編碼史賓諾辛PKS模組的DNA序列，該模組是擇 自於序列辨識編號：2之6-1413、序列辨識編號：2之 1525-2513、序列辨識編號：3之1-2034、序列辨識編號： ___ - 17- 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 、?τ 線 經濟部智慧財產局員工消費合作社印製 A7 1237058 B7
五、發明説明（J 4之1-1506、序列辨識編號·· 4之1529-3053、序列辨識編 號：5之1-1726、序列辨識編號：5之1748-3269、序列辨 識編號：5之3291-4806、序列辨識編號：5之1-1726、序 列辨識編號：6之1-1726、序列辨識編號：6之1749-3500 和序列辨識編號：6之35434-5555胺基酸序列所組成之群 組中在一個較佳的實施例中，該DNA序列是擇自於序列 辨識編號：1 之氮鹼基 21126-24041、24102-28649、 29024-35125、35518-40035、40102-44676、45077-50254、 50318-54883 、 54947-59494 、 59902-65079 、 65146-70401 和70471-76566所組成之群組中。 另一方面，本發明提供一種重組型DNA載體，其中 包含如上面說明的本發明DNA序列。 另一方面，本發明提供一種為如上面說明的本發明 重組型載體所轉形之宿主細胞。 另一方面，本發明提供一種增加生產史賓諾辛的微 生物之史賓諾辛生產能力的方法，其中包含下面步驟 1) 以一重組型DNA載體或其部份來轉形一微生物， 該微生物藉由一生物合成途徑會生產史賓諾辛或史賓諾辛 前驅物，該載體或其部份包含有如上說明的本發明之一 DNA序列，該DNA序列編碼一在該途徑中係為速率受限 制的活性之表現；及 2) 在適合細胞生長和分裂、該DNA序列之表現以及 生產史賓諾辛之條件下，培養為該載體所轉形之該微生 物。 -18 - 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇><297公釐） (請先閲讀背面之注意事項再填寫本頁) 、?τ 線 經濟部智慧財產局員工消費合作社印製 1237058 A7 經濟部智慧財產局員工消費合作社印製 五、發明説明（ 另一方面，本發明提供一種生產史賓諾辛的微生物， 其含有能操作的史賓諾辛生物合成基因，其中史賓諾辛生 物合成基 m spnA、spnB、spnC、spnD、spnE、spnF、spnG、 spnH、spnl、spnj、spnK、spnL、spnM、spnN、spn〇、、 、史賓多泡酵母菌、史賓多泡酵母 菌尽^、史賓多泡酵母菌印ζ·和史賓多泡酵母菌灸中至少 有一者被複製。 另一方面’本發明提供一種生產史賓諾辛的微生物， 該微生物之基因組中含有史賓諾辛生物合成基因、矣今毛 少該等基因中之一者藉由重組而在該基因之一内部片段被 破壞，而該基因之其餘部份係能操作而生產一種史賓諾 辛，該史賓諾辛不同於若該被破壞的基因能操作而生產出 者。較佳地該微生物是一種史賓多泡酵母菌變異體。 本發明也提供一種生產史賓諾辛的微生物，該微生 物在其基因組内含有能操作的史賓諾辛生物合成基因，其 中該等基因a)包含比序列辨識編號：丨中所存在者至少多 一個或至少少一個操作PKS模組；或…包含一個與序列辨 識編號：1中所述之對應的模組不同的PKS模組，該不同 係藉由KR、DH或ER區域之刪除、去活化或加入或是藉由 會設定一不同的羧酸之一 AT區域的取代。較佳地該微生 物是一種史賓多泡酵母菌變異體。 本發明也提供由本發明新穎微生物之培養而得到的 史賓諾辛。 另一方面，本發明提供一種分離史賓諾辛生物合成 本^家縣(；)Α4· (210^^ I 1 ........ ! · -- * r ί^^-丨 (請先閲讀背面之注意事項再填寫本頁) -訂 線 A7 1237058 B7
五、發明説明（J 基因的方法，其包含建立生產史賓諾辛的微生物基因存 庫，及使用序列辨識編號：1之一至少有20個氮鹼基長的 標諸片段來作為雜交探針。 發明詳細說明 以A I部份消化產生的片段建立史X在I-酵普普 (N/HL 1 8395)DNA之粘接質體存庫。它們被選殖進入載 體 pOJ43 6(參考第 3圖）的 5amHI 位（Bierman等人，1992)， 並以體外包裝作用和轉導作用引入大腸桿菌細胞。以這方 法製得的重組型細菌的存庫，以Solenberg和Burgett (1989) 的方法篩檢其與雜交的二個放射性標誌DNA探針的相似 性。一個探針是400 kb办el片段，此片段通常是以N-甲基 -Ν’-硝基亞硝基胍轉形作用或變異發生，從非產生史 賓多泡酵母菌菌株被刪除而得到的（Matsushima等人， 1994)。第二個探針是編碼不包含於史賓諾辛生物合成酮 合成酶的部份的史賓多泡酵母菌DNA的300bp片段（Β·Ε· Schoner，個人的簡短報告）。包含所有聚烯酮和脂肪酸合 成酶基因保留的區域，因此可以用史賓諾辛PKS基因交雜 交。粘接質體9A6和2C10是可與二探針雜交的七種選殖中 的二種。粘接質體3EII是擇自粘接質體9A6 (序列辨識編 號·· 1之氮鹼基26757-26936)放射性標誌处rAUamHl片段 雜交的基因存庫。為了測定核苷酸序列的嵌入粘接質體 9A6，將5⑽HI片段次選殖入質體p〇J260(參考第4圖）的 5amHI位（Bierman等人，1992)。嵌入這些質體的序列以二 方法之一測定。在一個方法中，次選殖的片段以心w3 A 1 -20- 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 、tr -線 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（j (請先閲讀背面之注意事項再填寫本頁，> 經濟部智慧財產局員工消費合作社印製 部份消化，以大小選擇的片段選殖到噬菌體Ml 3mp 19 DNA 的5amHI位。由任意選擇的重組型製備單股DNA，使用ABI (Applied Biosystems，Inc·，Foster，CA)的試劑和裝置，依 照Burgett & Rosteck (1994)的方法，以螢光循環排序法排 序列。各質體噬菌體次選殖的序列組合成一個連續的序 列。在另外一個排序的方法，雙股質體DN A以單股寡核 苷酸反覆地啟動，各自設計以互補區域接近先前測定 列的一端。因此，由一系列部份重疊的序列編譯完全序列。 以Prism-Ready Sequencing Kits (ABI) ’ 依照製造者的 ％ 明，以ABI373A序列器分析。以相同的方法經由雙股9A6 DNA的位排序列。這些數據使得次選殖的序列互相 聯結，並相關地排列，使用MacVector Program之ASsembly LIGN模組（Oxford Molecular，Campbell，KY)，因此組構 了粘接質體9Α6之史賓多泡酵母菌DNA的整個核苷酸序 列。粘接質體2C10和3E11的完整序列，以噬菌體Ml3選 殖之任擇的DNA片段，用螢光循環排序法（SeqWright， Houston，TX)來測定。粘接質體2C10和3E11的嵌入重叠， 3E11的嵌入與粘接質體9A6的嵌入端重疊。參考第2圖。 同時，三個粘接質體嵌入橫跨約80kb單一序列（序列辨識 編號：1)。下面的表3確認包含於三個嵌入的各個序列辨 識編號：1部份。 -21- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（4 表 3 嵌入部份 序列辨識編號：1之氮鹼基 粘接質體9A6 1-2694! 粘接質體3E11 23489-57287 粘接質體2C10 (已校正） 41429-80161 — 第2圖為圖示三個嵌入與序列$ 的關係。 必須注意的是粘接質體2C10丢掉了序列辨識編號·· 1 的氮驗基G41877、C45570、C57845和G73173。測定這些 刪除以進行人工選殖。刪除現象產生縮短PKS聚腈的架構 内終止密碼子。其中之一發生在也選殖於粘接質體3E11 的區域，但不在得到序列的3E11區域。因此未選殖的DNA 延伸於PKS區域的所有8個終止密碼子直接從史賓多泡酵 母菌（NRRL 18395)染色體PCR擴大區域排序列。從未選殖 的DNA的序列確認在ACP區域端存在的4個終止密碼子， 並證實其他編碼區域内4個架構位移為粘接質體2C10僅有 的人工選殖。 PKS基因 序列辨識編號·· 1包括編碼已知的大環内酯物產生者 的聚烯酮合成酶DNA攻擊相似性的約55kb的中心區域 (Donadio等人，1991 ; MacNeil等人，1992 ; Schwecke等 人，1995 ; Dehoff等人，1997)。史賓諾辛PKS DNA區域 包含5個ACP在區域端有架構内終止密碼子之0RF ’與其 他生產大環内酯物細菌之PKS ORF相同。這五個史賓諾辛 PKS基因是頭·尾排列的（參考第2圖），沒有任何非PKS# -22- 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7五、發明説明（2] 能介入，如紅黴素PKS基因AI和All間發現的嵌入元素 (Donadio等人，1993)。它們被稱為 57^3、印《5、印/iC、、 和Wn五。這五個史賓諾辛PKS基因個別的核苷酸序列和對 應的聚肽被確認於下面的表4 : 表 4 基因 序列辨識編號：1内之氮鹼基 對應的聚肽 spnA 21111-28898 序列辨識編號 2 spnB 28916-35374 序列辨識編號 3 spnC 35419-44931 序列辨識編號 4 spnD 44966-59752 序列辨識編號 5 SpnE 59803-76569 序列辨識編號 6 編碼起始模組（序列辨識編號·· 1，氮鹼基21126-24041)和延伸模組1(序列辨識編號：1，氮鹼基24102-28649)。起始模組和延伸模組1内各功能區域的核苷酸序 列和對應的胺基酸序列被確認於下面的表5 : (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 表5 spnA 區域 序列辨識編號：1内之氮鹼基 序列辨識編號：2内之胺基酸 KSi 21126-22379 6-423 Ati 22692-23669 528-853 ACPi 23793-24041 895-977 KSI 24102-25349 998-1413 ATI 25683-26684 1525-1858 KR1 27582-28121 2158-2337 ACPI 28404-28649 2432-2513 編碼延伸模組2 (序列辨識編號：1，氮驗基 29024-3 5125)。延伸模組2内各功能區域核苷酸序列和對 應的胺基酸序列被確認於下面的表6 : -23- 本紙張尺度適用中國國家標準（CNS ) Α4規格（210 X 297公釐） [237058 A7 B7 五、發明説明（ 表6
SpnB 區域 KS2 AT2 DH2 ER2 KR2 ACP2 序列辨識編號： 序列辨識編號：3内之胺基酸 29024-30295 30629-31 621 31697-32254 33035-34072 34082-34621 34886-35125 1-424 536-866 892-1077 1338-1683 1687-1866 1955-2034 編碼延伸模組3 (序列辨識編號·· 1 ’氮驗基 35518-40035)和延伸模組4 (序列辨識編號：1 ’氮驗基 40102-44676)。延伸模組3和4内各功能區域的核苷酸序列 和相對的胺基酸序列確認於下面的表7 : 表7 (請先閲讀背面之注意事項再填寫本頁) spnC 區域 序列辨識編號：1内之氮鹼基 序列辨識編號：4内之胺基酸 KS3 35518-36786 1-423 AT3 37108-38097 531-280 KR3 38992-39528 1159-1337 ACP3 39790-40035 1425-1506 KS4 40102-41373 1529-1952 AT4 41713-42705 2066-2396 KR4 43615-44157 1 2700-2880 ACP4 4443 1-44676 2972-3053 經濟部智慧財產局員工消費合作社印製 spnZ)編碼延伸模組5 (序列辨識編號：1，氮驗基 45077-50254)，延伸模組6 (序列辨識編號·· 1，氮鹼基 50318-54883)，和延伸模組7 (序列辨識編號：1，氮鹼基 54947-59494)。延伸模組5、6和7内各功能區域的核苷酸 序列和對應的胺基酸序列被確認於下面的表8 : -24- 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） A7 1237058 B7 五、發明説明（^ 表8 SpnD 區域 序列辨識編號：1内之氮鹼基 序列辨識編號：5内之胺基酸 KS5 45077-46348 1-424 AT5 46691-47674 539-866 DH5 47753-48310 893-1078 KR5 49226-49771 1384-1565 ACP5 50009-50254 1645-1726 KS6 503 18-51592 1748-2172 AT6 51923-52915 2283-2613 KR6 53822-54361 2916-3095 ACP6 54638-54883 3188-3269 KS7 54947-56215 3291-3713 AT7 56549-57535 3825-4153 KR7 58106-58990 4344-4638 ACP7 59249-59494 4725-4806 (請先閱讀背面之注意事項再填寫本頁) 印ηΐ：編碼延伸模組8 (序列辨識編號：1，氮鹼基 59902-65079)，延伸模組9 (序列辨識編號：1，氮鹼基 65146-70401)和延伸模組10 (序列辨識編號：1，氮鹼基 70471-76566)。延伸模組8、9和10内各功能區域的核苷酸 序列和對應的胺基酸序列被確認於下面的表9 : 訂 經濟部智慧財產局員工消費合作社印製 __-25- 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐) 1237058 at B7 五、發明説明（2i 表9 spnE 區域 序列辨識編號：1内之氮鹼基 序列辨識編號：6内之胺基酸 KS8 59902-61173 1-424 AT8 61489-62445 530-848 DH8 62548-63111 883-1070 KR8 64006-64557 1369-1552 ACP8 64843-65079 1648-1726 KS9 65146-66420 1749-2173 AT9 66760-67743 2287-2614 DH9 67819-68301 2640-2800 KR9 69370-69924 3157-3341 ACP9 70165-70401 3422-3500 KS10 70471-71745 3534-3948 AT10 72079-73071 4060-4390 DH10 73138-73692 4413-4597 KR10 74599-75135 4900-5078 ACP 10 75415-75660 5172-5253 TE10 75805-76566 5302-5555 (請先閲讀背面之注意事項再填寫本頁)
、1T 前述表5-9確認的50個區域界限和功能是根據其他聚 烯酮合成酶區域，特別是紅黴素聚烯酮合成酶，保留的胺 基酸序列的相似性預估（Donadio等人，1992)。未預期的KSi 起始模組胺端區域是假設為非功能性的，因為它在胺基酸 172含有麩醯胺酸殘基，取代了 β-酮合成酶活性必須的半 胱胺酸（Siggard-Andersen，1993)。在泰樂黴素PKS起始模 組也發現一個類似的非功能性KS區域（Dehoff等人， 1997)。其他的史賓諾辛PKS區域是功能性的。未 J务現紅黴素和rapamycin f各各基厘發^ ·區爲蘇库 列特性（Donadio 等人，1991 ; Aparicio 等人，1996)。這 ^~ , 、 些選殖的PKS基因顯示是史賓諾辛生物合成必須的，因為 發現這些基因被破壞的史賓多泡酵母菌菌株發酵不能得到 ___-26-_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐) 線 經濟部智慧財產局員工消費合作社印製 A7 B7 經濟部智慧財產局員工消費合作社印製 1237058 五、發明説明（2)4 史賓諾辛。將一個基因的内部片段，以文獻中已知的方法， -------------. 選殖進入質體P〇J260 (第4圖）達到基因破壞。然後將該重 組型質體，以Matsushima等人的方法，從大腸桿菌結合， 引入史賓多泡酵母菌（1994)，選擇抗阿布拉黴素外結合 體。以pOJ260為基質的質體不會獨立地在史賓多泡酵母 菌複製，而是穩定地經由選殖的DNA和其染色體同系序 列之間重組質體同化作用維持於染色體。同化作用在染色 體内產生二個不完全版本之目標基因（一個缺少5’序列， 一個缺少3’序列），二者之間有pOJ260 DNA。史賓諾辛的 生物合成被分別相對於下面序列辨識編號：1的片段： 21365-22052、22052-24338 或 24338-26227 之 5amHl 片段 V、N或K破壞ORF而阻斷。史賓諾辛的生物合成也 以5amHl片段G、E或K，分別相對於下面的序列辨識編號： 1片段：氮鹼基 48848-50578、50578-52467 或 55207-55888 破壞WAzi) ORF而阻斷。史賓諾辛的生物合成也以分別相 對於下面序列辨識編號：1的片段：63219-63989、65406-66733、66733-68997 ' 69369-7073 1 和 7073 1-72675 的心mHl 片段J、I、D、Η和F破壞πηί： ORF而阻斷。史賓諾辛的生 物合成不會經由5amHl片段C (序列辨識編號：1之氮鹼基 44612-47565)或B (序列辨識編號：1之氮鹼基55936-63219) 的同化作用被阻斷，因為它們不在任何一個基因的内部； 5amHl片段C延伸在和以?/2乃之間連接處，而片 段B延伸在和之間連接處。在這些情況下’同化 作用留下一個各基因完全版本。 _^__-27-__ 未紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁)
1237058 at B7 五、發明説明（』 鄰近PKS基因的再修飾 在PKS基因DNA上游（選殖於粘接質體9A6)，有16個 開放閱讀架構（ORF)，各包含至少100密碼子，以ATG或GTG 開始，以TAA、TAG或TGA結束，具有密碼子傾向預期的 DN A含有高百分比鳥嘌呤和胞癌唆殘基之生物體内蛋白 質-編碼區域（Bibb等人，1984)。參看第2圖，9A6的16個 ORF的圖示。根據此後討論的證據，ORF中的14個被認為 是史賓諾辛生物合成基因，稱為：尸、WnC?、wnif、ww/、 spnJ、spnK、spnL、SpnM、spnN、spnO、spnP、spnQ、spnR 和叹M (在第2圖内標示F到S)。在下面的表10裡面，相關 聚肽的DNA序列和胺基酸序列確認此等各個基因，及二 個ORF (ORFL15和ORFL16)，就在以上游被發現。表10 也確認在PKS基因下游的ORFR1和ORFR2核苷酸序列（在 粘接質體2C10)及其等對應的胺基酸序列。 (請先閱讀背面之注意事項再填寫本頁) 訂 線 經濟部智慧財產局員工消費合作社印製 -28- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 B7 經濟部智慧財產局員工消費合作社印製 1237058 五、發明説明（2¾ 表10 基因 序列辨識編號：1内之氮鹼基 聚肷 spnF 20168-20995 序列辨識編號：7 spnG 18541-19713(C) 序列辨識編號：8 spnH 17749-18501(C) 序列辨識編號：9 spnl 16556-17743 序列辨識編號：10 spnJ 14799-16418(C) 序列辨識編號：11 spnK 13592-14785(C) 序列辨識編號：12 spnL 12696-13547(C) 序列辨識編號：13 spnM 11530-12492(C) 序列辨識編號：14 spnN 10436-11434 序列辨識編號：15 spnO 8967-10427 序列辨識編號：16 spnP 7083-8450 序列辨識編號：17 spnQ 5363-6751(C) 序列辨識編號：1 8 spnR 4168-5325(C) 序列辨識編號：19 spnS 3416-4165(C) 序列辨識編號：20 ORFL 15 2024-2791 序列辨識編號：21 ORFL 16 1135-1971(C) 序列辨識編號：22 ORFR 1 76932-77528 序列辨識編號：23 ORFR 2 77729-79984 序列辨識編號：24 (C)表示在序列表内為互補鏈 利用三種證據確認聚肽在表10確認的功能：已知的 功能序列的相似性，目標基因破壞實驗的結果’和生物轉 形實驗的結果。 預測聚肷的胺基酸序列與儲存於the National Center for Biotechnology Information (NCBI，Washington，DC) 資料庫的序列比較，以BLAST推算法測定與已知蛋白質 的相關性。也定期重複地進行NCBI資料庫BLAST，從增 加的同系物得到新的知識。表11是1998年1月12日從基本 BLAST搜尋得到的最佳配對： _______-29-_ _ 本紙張尺度適用中國國家標準（CNS ) M規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁)
1237058 at Β7五、發明説明（2) 經濟部智慧財產局員工消費合作社印製 表11 基因 有意義的蛋白質配對 GenBank Accession BLAST 積數* 報告的功能 spnF C-24固醇曱基轉移酶 (Zea mays) U79669 202 c-甲基化 spnG Daunosamyl轉移酶 (Streptomyces peucetius) L47164 202 糖類加成 spnH Mycinamicin III 0-甲基轉移酶 (Micromonospora griseorubida) D16097 408 糖類曱基化 spnl ORFY {Streptomyces nogalater) Z48262 192 未知 spnJ 六糖乳化酶(Chondrus crispus) U89770 143 $化-還原反應 spnK ORFY (Streptomyces nogalater) Z48262 137 未知 spnL C-24固醇甲基轉移酶 (Zea mays) U79669 166 C-甲基化 spnM 未知 {Mycobacterium tuberculosis) Z95586 132 未知 spnN RdmF (Streptomyces purpuras certs') U10405 409 未知 spnO 2,3-脫水酶公75V1 {Saccharopolyspora erythraed) Y11199 595 脫氧糖類合成 spnP Mycarosyl轉移酶 (Saccharopolyspora erythraea) U77459 336 糖類加成 spnQ CDP-4-酮-6-脫氧-D-葡萄糖-3-脫水酶e/zieriaz) P26398 784 二脫氧糖類合成 spnR 孢覆多醣生物合成蛋白質 {Bacillus subtilis) P39623 286 糖類胺轉化蛋白 質 spnS TDP-N-二曱基desosamine-N-曱 基轉移酶f〇；CVI {Saccharopolyspora erythraea) U77459 484 胺糖類甲基化 ORFL1 5 酮乙醯基還原酶 {Streptomyces cinnamonensis) 211511 132 氧化-還原反應 ORFL1 6 此操作子調控蛋白質， subtilis) 轉譯控制 ORFR1 無 ORFR2 結合移轉蛋白質 {Bacillus subtilis) Z99117 328 DNA複製 *BLAST積數越高，相似性越大（Altschul等人，1990)。 在目標基因破壞方面，由枯接質體DNA PCR放大， 並選殖入質體pOJ260而產生内部片段。然後將得到的質 __________13〇：_ 本紙張尺度適用中國國家標準（CNS )A4規格（210 X 297公釐) I . I - I I»— I - - if.^—..... - -- —lj I (請先閲讀背面之注意事項再填寫本頁)
、1T 線· 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製
五、發明説明（2) 體結合史賓多泡酵母菌（NRRL 18395)，分離抗阿布拉黴 素外結合物並發酵。如前面的說明，破壞實驗的基礎是， 當帶有内部基因片段的質體被同化，得到二個不完全生物 合成基因，因此沒有了酵素的功能。分析得到的發酵產物， 測定聚集哪一種史賓諾辛。目標基因破壞實驗的結果摘要 說明於表12。 在生物轉形研究方面，史賓諾辛合成的菌株經過改 變，測試它有效史賓諾辛中間產物轉形為其他史賓諾辛的 能力。使用的中間產物是史賓諾辛A配質（AGL)、史賓諾 辛P(P)、史賓諾辛K(K)和史賓諾辛A9-Psa(PSA)。生物轉 形實驗的結果也摘要地說明於表12。 表12
破壞的基因 序列辨識編號：1 内部片段 聚集之史賓諾辛 生物轉形產物 AGL -> K-> PSA-> 無 無 A+D SpnF 20325-20924 無 A A A spnG 18818-19426 無 AGL K A spnG-H 18511-19559 P K A spnl 16699-17400 無 J A A spnJ 14866-15470 無 A A spnK 13785-14574 無 spnL 12791-13428 無 A A A spnM 11705-12371 3% A A A spnN 10636㈣11369 PSA spnO 9262-10226 PSA spnP 7391-8159 PSA PSA ORFL15 2145-2719 A+D ORFL16 1226-1852 A+D ORFR2 79321-79855 A+D _____-31 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（j 現在以基因為基礎，將由BLAST搜尋，基因破壞實 驗，和生物轉形研究得到的結論，更詳細地討論這些基因。 (請先閲讀背面之注意事項再填寫本頁) pks的11個基因上游顯示它們參與史賓語辛的生物合 成，因為破壞的菌株不能聚集主要的史賓諸辛入和D (表 12)。接下來PKS的2個基因上游（0RFL15、0RFL16)，和 大基因下游（0RFR2)，不能用於史賓諾辛的生產’因為它 的破壞不影響發酵（表12)。沒有嘗試緊接著PKS基因下游 ORF的破壞（0RFR1)，因為它太小，而不能得到可接受重 組頻率的内部片段。沒有嘗試及和印Μ基因的破 壞，因為早期的BLAST搜尋顯示，這些基因與已知的參 與不尋常脫氧糖類生物合成的酵素有類似的攻擊性。 在其基因產物參與*ewMWd細胞表面脂多醣阿 比可糖部份合成的CDP-4-酮-6-脫氧-D-葡萄糖-3-脫水酶之 間有53%相同性（Jiang等人’ 1991) ; 之產物和作為脫 經濟部智慧財產局員工消費合作社印製
氧糖類胺轉化酶功能的一組蛋白質之間有高達40%相同性 (Thorson等人，1993);而之產物和 ambofaciens，一種合成含 forosamine 抗生素 spiramycin 的 生物體的心所尤產物之間有42%相同性（Geistlich等人， 1992)。甚至從最近的BLAST搜尋得到更強的相似性（表 11)’基於這些相似性’和基因與其他史負諾辛生物合成 基因的密切聯結，得到的結論是、ani?和參與史 賓諾辛forosamine部份的生產。 spnF、SpnJ、svnL、SpnM 基因spni7、或破壞的菌株不能聚集 -32 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237〇58 A7 ___ B7 五、 經濟部智慧財產局員工消費合作社印製 發明説明（ (請先閱讀背面之注意事項再填寫本頁) 得到任何史賓諾辛有意義的含量（印變異種中低含量的 史賓諾辛A假設是得自在其羧端刪除的一些基因產物殘餘 的活性）。然而，它們生物轉形外供應的配質給史賓諾辛， 因此含有所有的史賓諾辛生物合成中後來步驟必須的酵 素。這些特別的基因一定參與由推定的PKS基因單環内醋 產物配質的產生。印…和”以碳-碳鍵橋形成時的角色與 其和甲酯碳原子酵素相似性一致（表11)。阻斷的變異種中 缺少部份修飾之中間產物可能是由於化合物的不穩定度， 或從由於缺少糖化分子作為正調節器而減少生物合成，類 似泰樂黴素途徑（Fish & Cundliffe，1997)。
^pnG、SpnH、spnL、SvnK 的破壞也阻斷史賓諾辛的生產，但是變異種菌 株不能生物轉形配質，因此這個基因在途徑的後面步驟是 需要的（表12)。由其序列與已知的糖化轉移酶基因的相似 性（表11)推測編碼配質加成第一個糖必須的鼠李糖基 轉移酶。破壞的變異種也沒有功能性的4，_〇_甲基^ 移酶（OMT)’因為它轉形3，，4’_二消甲基史賓諾辛為 4’-消甲基史賓諾辛（K)’而不成為完全甲基化史賓諾辛a。 4’-0MT活性假設不表現於變異種，因為編碼的基因咖幻 在相同的操作子破壞性同化作用的下游。此操作子的存在 以破壞5㈣H1片段T來確認，該片段延伸在啊G和，純之 間連接處，但不在任何開放閱讀架構的内部。然而，它破 壞改變的史賓諾辛合成，因此這—片段必須在= 基因周圍的内部。除了預期的由神丢掉4，_謝活性編
表纸張尺度適用中國國豕標準（CNS ) A4規格（210 X 297公羞T 33- 1237058 A7 ___ __B7 _ 五、發明説明（』 誚先閱讀背而之注意事項再項艿本页)
碼’此破壞也造成未預期的丟掉3，_〇MT功能，造成史賓 語辛P堆積（表12)。3’-OMT活性以匯聚的下游基因編碼， 印/2/。這個基因有最大的少ORF Y基 因序列相似性（表11)。 0RF γ產物的功能是未知的，但 '是該生物體產生一個不尋常的四甲基化脫氧糖類 (nogalose)，與史賓諾辛a三-甲基化鼠李糖類似，因此可 推測二基因都參與糖類甲基化。和這假設一致的，^^，的 破壞得到一個變異種，對史賓諾辛p只生物轉形為3、消甲 基史賓諾辛（J)，而沒有史賓諾辛A(表丨2)。在未補充的發 酵破壞避免任何史賓諾辛積聚。尺的序列和和〇rF Y相同，假設編碼2’-〇MT。它的破壞也避免任何史賓諾辛 積聚於未補充的發酵（表12)。 spnN - svn〇 > SvnP 經濟部智慧財產局員工消費合作社印製 基因印π#、叹/tO和的破壞造成准配質的積聚（表 12)。因此’這些基因參與生物合成或foroSamine糖類加成。 叹/zP和糖基化轉移酶的相似性（表u)顯示它編碼史賓諾辛 forosamyl轉移酶。吓⑽和2,3-脫水酶的高度相似性（表11) 顯示它參與forosamine合成步驟的2，_脫氧化反應。 鼠李糖基因 粘接質體9A6、3E11和2C10的重疊嵌入選殖不含有編 碼四種由葡萄糖產生鼠李糖需要的酵素的基因（Liu & ThGfson，1994)。第一個酵素是一個葡萄糖胸嘧啶酯轉移 酶（g")或相應的酵素，以加成核苷酸二磷酸酯（NDP)來活 化葡萄糖。第二個是一個葡萄糖脫水酶（尽以），產生NDP-4- ---------- 34 - _ 本紙張尺度適用中國國家榡準（CNS ) A*規格（21〇χ297公釐） 1237058 A7 _B7_ 五、發明説明（d (請先閲讀背面之注意事項再填寫本頁) 酮-6-脫氧葡萄糖，這是許多脫氧糖類生物合成途徑普遍 的中間產物。鼠李糖的合成也需要特定的表異構酶 和酮還原酶（々re)，使NDP-4-酮-6_脫氧-葡萄糖轉形為 NDP-L-鼠李糖，活化的糖類，糖基化轉移酶的受質，將 鼠李糖加到配質。史賓多泡酵母菌裡面編碼這些酵素的基 因從 λ載體 ZAP Express™ (Stratagene，LaJolla，CA)7-12 kb 部份心w3A I片段個別存庫選殖。放射性標誌探針之製備， 良以含有 Saccharopolyspora erythraea gdh 和 gtt基西質後 pESCl的片段，進行無規引發子延伸（Bo ehringer Mannheim， Indianapolis, IN)(Linton 等人，1995)。在 65°C，1小時， 以0·5χ SSC，0.1% SDS澈底洗滌，進行斑雜交篩檢噬菌體 存庫。含有嵌入載體的質體（pDAB 1620和pDAB 1621)部 份從三個雜交噬菌體中的二個切割，以Prism-Ready Sequencing Kits (ABI)和多引發子部份排序。排序的pDAB 1620 (序列辨識編號：25)嵌入部份包含編碼329-胺基酸聚 腈（序列辨識編號：26)的ORF，與*S· 產物g办有82% 經濟部智慧財產局員工消費合作社印製 相同性。鄰近這個基因的是一個275-胺基酸聚腈（序列辨 識編號·· 27)編碼的ORF，與基因產物有72% 相同性。排序列的pDAB 1621(序列辨識編號：28)嵌入部 份含有一個編碼261-胺基酸聚肽（序列辨識編號：29)的 011卩，與&6厂>^/^^^(35^基因產物有83%相同性。一個鼠 李糖基因第二探針，以簡併募核苷酸引子（序列辨識編號： 30和序列辨識編號：31)，依據已知的e/n·蛋白質裡面保留 的胺基酸區域，將史賓多泡酵母菌基因的DNA PCR放大 _^___135J；___ 本纸張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） ' 1237058 A7 B7_______ 五、發明説明（4 (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工涓費合作社印製 而製備（Jiang 等人，1991 ; Linton 等人，1995)。PCR反 應在基因 Amp 9600 Thermocycler，以 AmpliTaq 聚合肼 (Perkin-Elmer)，以 94°C 30秒，60〇C 30秒和 72°C 45秒， 進行30周期。探針在712kb存庫雜交成為一個噬菌體；含 有這個嵌入載體的質體部份（pDAB 1622)切割，部份排序 列（序列辨識編號：32)。它包含一個202胺基酸聚肽（序列 辨識編號：33)的ORF，與& erj/i/zMea e/η·蛋白質有57%相 似性。以含有内部片段（序列辨識編號：25的氮鹼基382-941、序列辨識編號：25的1268-1867、序列辨識編號：28 的447-994或序列辨識編號：32的346-739)的質體重組而 破壞基因。在所有的情況都得到抗阿布拉黴素外結合物， 但它們都只能在滲透壓穩定的培養基，如蔗糖200 g/L補 充之CSM，或R6 (Matsushima等人，1994)生長。甚至在 這些條件下，它們的生長都比原來的史賓多泡酵母菌 CNRRL 18395)慢很多，而且在形態上是可區分的，有更 多的片段菌絲。這些結果可能是因為史賓多泡酵母菌細胞 壁有鼠李糖，生物體内正常細胞壁的合成必須有這四個基 因。在這些基因破壞的變異種生長太慢，而不能在已知產 生史賓語辛的條件下發酵。然而，以& 探針（於2x SSC，65°C 0.1%SDS，洗1小時）或以簡併性e/π· 探針（washed in 於 O.lx SSC，65°C 0.1%SDS洗 1 小時）史賓 多泡酵母菌基因的DNA沙頓雜交，顯示在史賓多泡酵母 菌染色體内沒有這些基因其他的同系物。因此，這四個選 殖的史賓多泡酵母菌基因必定是細胞壁形成和史賓諾辛生 ____ -36- ___ 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐丁 ^ A7 1237058 B7 五、發明説明（3\ 物合成僅有的鼠李糖來源。 (請先閲讀背面之注意事項再填寫本頁) 四個產生鼠李糖需要的史賓多泡酵母菌基因的各核酸 肟序列和相對的胺基酸序列確認於下面的表13 : 表13 基因 DNA序列 胺基酸序列 史賓多泡酵母菌济/ 序列辨識編號：28，氮鹼基334-1119 序列辨識編號：29 史賓多泡酵母菌g说 序列辨識編號：25，氮鹼基88-1077 序列辨識編號：26 史賓多泡酵母菌epi 每列辨識編號：32，氮鹼基226-834 序列辨識編號：33 史賓多泡酵母菌 序列辨識編號：25，氮鹼基1165-1992 序列辨識編號：27 因此，史賓多泡酵母菌的23個基因可確認在史賓諾 辛生物合成的角色：5個PKS基因得到大環内酯，4個基因 修飾這個配質，5個基因合成和加成鼠李糖，3個基因甲基 化鼠李糖，及6基因合成和加成forosamine。假說性的生 物合成途徑摘要說明於第1圖。 實用性 經濟部智慧財產局員工消費合作社印製 選殖的史賓多泡酵母菌DNA有許多用途。選殖的基 因可用來增加史賓諾辛收率，生產新的史賓諾辛。可以用 特定菌株染色體同化入一個菌株内該速率限制酵素的基因 複製版本，而增加的收率。在一個很特別的情形下，當一 種特別的變異種菌株，因為缺少必要的酵素而阻斷其生物 合成途徑，可同化該必要基因複製品而恢復生產所要的史 賓諾辛。同化史賓諾辛基因複製品而收率增加的情形說明 於以後的實施例1 -3和6。 以選殖的DN A片段破壞史賓諾辛生物合成的步驟可 得到新穎的史賓諾辛。這種破壞可能造成前驅物或“分流” __-37- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 A7 Γ^—-----______ 五、發明説明（3) 產物（自然進行的前驅物衍生物）的積聚。可用於進行破壞 的片段是略去基因的5,和3,端氮鹼基的基因内部片段。用 這些片段的同系重組得到二個基因的部份複製品··一個是 /又有省略的5’端氮鹼基，另一個是沒有省略的3，端氮鹼 基。片段各端省略的氮鹼基數目必須夠大，使基因部份複 製品都不保留活性。通常從各端省略至少⑽個氮鹼基，更 佳的，從各端省略至少100個氮鹼基。部份基因片段的長 度必須夠大，使得重組頻率夠高可做實際的實驗。可用於 破壞的片段需要至少300個氮鹼基長，更佳的，至少約6〇〇 個氣驗基長。破壞基因得到的修飾史賓諸辛本身必須是昆 蟲抑制劑，或可作為進一步化學修飾的受質，產生具有特 疋性質和活性圖譜的新半合成史賓諾辛。以後的實施例4 說明此破壞方法的用法。 經濟部智慧財產局員工消費合作社印製 用選殖基因的變異發生，產生史賓諾辛生物體變異 種基因取代其未變異種部份，也可以得到新穎的史賓諾 辛。變異發生可以包括，例如：1)刪除或去活化KR、DH 或ER區域，阻斷一個或更多個這種功能，使得菌株產生 的史賓諾辛含有雙鍵、羥基或酮基的内酯核，這些是不存 在於史賓諾辛A核的（參考Donadio等人，1993) ; 2)置換AT 區域，將不同的羧酸加入内酯核（參考Ruail等人，1997); 3)KR、DH或ER區域加成到已存在的PKS模組，使得菌株 產生的史賓諾辛含有飽和鍵、羥基或雙鍵的内酯核，這些 是不存在於史賓諾辛A核的；或4)加入或減去整個的PKS 模組，使得該環狀内酯核有更大或較少數目的碳原子。實 _'___________-38- 本紙張尺度適用中國國家標隼（CNS ) A4規格（210X297公釐） ' '' ~ A7 1237058 B7 五、發明説明（36 ) 施例5說明使用變異發生產生修改功能性的史賓諾辛。 史賓諾辛基因群區域的DNA可作為確認同系序列的 雜交探針。因此，此處選殖的DNA可作為從史賓多泡酵 母菌基因存庫定位另外的質體，與該存庫此處說明的區域 重疊，但也含有史賓多泡酵母菌染色體鄰近的區域先前未 選殖的DNA。另外，此處選殖區域的DNA可用來確認其 他生物體中非相同，但相似的序列。雜交探針通常至少約 20個氮鹼基長，並有標示准許偵測。 本發明提供的修飾菌株可以用一般的方法，如揭示 於美國專利案件第5,362,634號者培養，提供史賓諾辛。 提供下面的實施例，使得本發明可以被更完全地瞭 解。它們不是用來限制本發明的。 實施例1 以粘接質體9A6之轉形來增加史賓諾辛A和D收率 史賓多泡酵母菌菌株NRRL18538植物培養生長於 50ml CSM培養基（trypticase大豆發酵液30g/l，酵素萃取物 3g/l，硫酸鎂2gn，葡萄糖5g/l，麥芽糖4g/l)，於50 ml三 ，角燒瓶，30°C 300 rpm震盪48小時。發酵培養含有lml植 物培養於7ml INF202之培養液，這是一種與Strobel &
Nakatsukasa (1993)說明相同的適當培養基。培養基於30ml 塑膠瓶生長，安排為10x10模組，於30°C房間300 rpm震盪 3天，5天或7天。發酵液以4倍體積之乙萘萃取，然後以 isocratic高壓液體層析法（HPLC)，通過C-18逆相管柱分析 史賓諸辛A+D(Strobel和Nakatsukasa，1993)。史賓語辛的 _^_139J：_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁)
、1T 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（37 ) 量以250nm吸收度測定。在各時間點，測定10個發酵瓶中 史賓諾辛A+D的含量。各組複製品中二個代表性的樣品也 以略微改變的HPLC系統分析准配質（PSA)，它是沒有 for os amine的史賓諾辛前驅物。在這系統裡，流動相是35 : 35 : 30 乙萘 / 甲醇/0.5% (w/v)醋酸銨水溶液（R· Wijayaratne， 未發表資料）。 此培養不僅含有具昆蟲活性的史賓諾辛A和D，也含 有准配質（表14)。 表14 菌株NRRL18538之史賓諾辛生產 (請先閱讀背面之注意事項再填寫本頁) 時間 A+D (pg/ml) PSA (pg/ml) 3天 101 ± 3 109 ± 11 5天 269 ± 14 155 ± 26 7天 334 ± 32 110 ± 53 此數據為平均+ 95%可信度。
、1T 從准配質，缺少forosamine的史賓諾辛A前驅物，的 積聚推測，在這些條件下生長的菌株中，史賓諾辛A+D的 收率受forosamine的供應及/或添加的限制。 枯接質體9A6，以Matsushima等人（1994)方法，由E· coli菌株S17-1 (Simon等人，1983)結合到史賓多泡酵母菌 菌株NRRL18538。接著，六個以粘接質體9A6轉形的獨立 分離物生長，並在上面說明的發酵條件下分析史賓諾辛遺 傳因子的產生。這些菌株的史賓諾辛A+D平均收率較其母 體高，發酵3天後高35 pg/ml，5天後高3 7 pg/ml。在整個發 酵期間，轉形培養中准配質的含量低於其母體菌株的含量 _'_-40-_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 線 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7五、發明説明（38 ) (表 15) 〇 表15 以粘接質體9A6轉形的NRRL18538衍生物中史賓諾辛生產量 時間 A+D (pg/ml) PSA (pg/ml) 3天 136 土 4 31 土2 5天 306 土 5 7 ±2 7天 365 ± 7 7±1 此實驗數據為平均值+ 95%可信度。 發酵期間，菌株NRRL 18538和6個以粘接質體9A6轉 形的獨立分離物在不同的時間分析史賓諾辛含量。各菌株 從10個發酵瓶測定史賓諾辛A+D(表16)的含量。也分析各 組複製品的二個樣品准配質含量（表17)。 表16 I —J ： 嶙丨 (請先聞讀背面之注意事項再填寫本頁) 訂 粘接質體9A6對NRRL 18538中史賓諾辛A+D的影響 時間 -9A6 + 9A6 9A6影響 3天 101 ± 3 136 ± 4 + 35% 5天 269 ±14 306 土5 + 14% 7天 334 ±32 365±7 + 9% 9天 414 ±17 411±8 -1% 此實驗數據為平均值（pg/ml) + 95%可信度。 經濟部智慧財產局員工消費合作社印製 表17 粘接質體9A6對NRRL 18538中准配質積聚的影響 時間 -9A6 + 9A6 9A6影響 3天 109±11 31±2 -72% 5天 155±26 7 ±2 -95% 7天 110土53 7±1 -94% 9天 119土11 5±1 -96% 此實驗數據為平均值（pg/ml) + 95%可信度。 _-41 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 1237058 B7 五、發明説明（39 ) 由此證明，以粘接質體9 A6的轉形可增加前驅物准配 質改變為史賓諾辛的效率。在NRRL 1853 8，史賓諾辛A+D 收率的增加，在發酵3天後是35%，5天後是14%(表15)。 速率的限制是由於foros amine的供應及/或加入。因為在發 酵過程中，准配質在母體菌株的含量大約是120 pg/ml， 但在第3天時，在轉結合物中減少為30pg/ml，而且以後也 明顯地減少（表15)。雖然這個轉形不是量化的，但這個數 據與在粘接質體9A6轉形的菌株中，准配質改變為史賓諾 辛A+D增加的影響是一致的。這個影響可能是複製 forosamine生物合成基因，forosaminyl轉移酶基因，或改 善組合的結果。7天或9天發酵後，有或沒有粘接質體9A6 之NRRL 18358菌株的史賓諾辛A+D收率，沒有統計學上 有意義的差異。轉結合物准配質的含量仍然減少，但是由 於在此發酵階段高含量史賓諾辛的聚集，由於轉換額外生 產的史賓諾辛A+D可能未被偵測到。 實施例2 以粘接質體9A6修正菌株NRRL 18823甲基化缺陷 雖然史賓語辛的合成受到forosamine供應/加入菌株 NRRL 18358的限制，在其他菌株中也可能限制其他的生 物合成功能。史賓多泡酵母菌菌株NRRL 18823聚集史賓 諾辛Η (2，-消曱基-史賓諾辛A ; Kirst等人，1992)，而非 史賓諾辛A。史賓諾辛Η不是史賓諾辛A生物合成途徑的 中間產物，而是一個在未發生2’-0-甲基化時，天然合成 的“分流”產物。粘接質體9A6以上面說明的方法，由大腸 _；__ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 f 1237058 A7 B7 五、發明説明（4〇 ) 桿菌菌株S17-1結合進入菌株NRRL 18823。發酵後得到的 外結合物中的二個，得到的主要是史賓諾辛A，和少量的 史賓諾辛Η (表18)。 表18 菌株 Η(μ§/ιη1) A+D (pg/ml) NRRL 18823 323 0 NRRL 18823/9A6-2 36 551 NRRL 18823/9A6-5 45 646 這個結果顯示，粘接質體9Α6的轉形可克服菌株NRRL 18823甲基化缺陷對第二形式史賓諾辛的生產限制。 實施例3 以粘接質體9Α6修正菌株NRRL 18743之4’-0-甲基化缺陷 史賓多泡酵母菌菌株NRRL 18743聚集史賓諾辛K (4’-消甲基-史賓諾辛A)，它是史賓諾辛A生物合成途徑的中 間產物。含有粘接質體9A6菌株NRRL 18743外結合物的 二個得到的主要是史賓諾辛A，和少量的史賓諾辛K，而 第三個沒有得到可偵測的史賓諾辛K(表19)。 表19 菌株 K(pg/ml) A+D (pg/ml) NRRL 18743 488 0 NRRL 18743/9A6-1 38 829 NRRL 18743/9A6-2 22 725 NRRL 18743/9A6-3 0 706 這個結果證明，粘接質體9A6的轉形可克服菌株NRRL 18743的甲基化缺陷對史賓諾A生產的第三形式限制。 ____1431_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） I ： !. 邊丨 (請先閲讀背面之注意事項再填寫本頁) 訂 -線· 經濟部智慧財產局員工消費合作社印製 A7 1237058 B7 五、發明説明（41 ) 實施例4 印/2P破壞引起的史賓諾辛前驅物積聚 一個尸内部片段（氮鹼基7391-8 159)用序列辨識編 號：34和序列辨識編號：35的引子，利用聚合酶鏈反應法 來擴大之。依照製造者的指示，以AmpliTaq聚合酶（Perkin Elmer，Foster City，CA)，以各引子 20 pmole和 lpg 9A6 DNA ΙΟΟμΙ反應。混合物經過25周期94°C 60秒，37°C 60秒，和 72°C 120秒。放大的產物當作五coRl-i^ndlll片段，選殖入 質體載體p〇J260(Bierman等人，1992)，然後從大腸桿菌 S17-1結合入史賓多泡酵母菌NRRL 18538。從帶有質體和 染色體的序列，從單一同系重組物，得到的穩定外結合物， 含有載體DNA同化入以^尸之二個不完全複製品染色體之 間的複製品。發酵後，這些外結合物聚集缺少forosamine 的前驅物准配質，而非史賓諾辛A和D終產物（表20)。 I----；--.---^0 — (請先閲讀背面之注意事項再填寫本頁) 、?τ 經濟部智慧財產局員工消費合作社印製 表20 菌株 PSA (pg/ml) A+D (pg/ml) NRRL 18538 79 284 NRRL 18538/1614-2 416 22 NRRL 18538/1615-1 372 21 NRRL 18538/1615-2 543 21 NRRL 18538/1615-5 476 19 NRRL 18538/1615-6 504 18 這些准配質為製備已知殺蟲劑有用的中間產物 (International Application WO 93/09126)。 -線· -44- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（42) 實施例5 ER2之PKS區域修飾後新穎史賓諾辛的藉聚 設計一個重疊，互補的募核苷酸序列辨識編號：36 和序列辨識編號：37用來修飾編碼史賓諾辛PKS模組2之 烯醇還原酶功能的基因。這些變異種的引發子，以TCACC 序列取代序列辨識編號：1氮鹼基33563-33567的GGTGG， 使在公認的NAD(P)H-結合特色中，該序列編碼為絲胺酸-脯胺酸二肽，而非甘胺酸-甘胺酸二肽。一個類似的取代 反應也成功地用於去活化紅黴素ER，而不影響任何其他 PKS的功能（Donadio等人，1993)。此取代反應同時也引入 一個新的尸Μ A1限制位，而除去5grAl位，利於彳貞測重組型 生物體内設計的DNA的。 在變異發生第一步驟，分別進行二個PCR放大，一個 使用變異種的引子序列辨識編號：36和側面相接引發子序 列辨識編號：38,另一個使用變異種的引子序列辨識編號： 37和側接引子序列辨識編號：39。第二步驟，將第一反應 的產物稀釋1〇〇倍，匯集，而僅用侧接引子序列辨識編號： 38和序列辨識編號：39並擴大。第三步驟，依照製造者 (InVitirogen，San Diego, CA)指示，將第二個 PCR反應產 物選殖進入質體pCRII。變異種ER2區域（序列辨識編據：
1延伸氮驗基33424-33626)的一部份切割為11-#/^1片 段，並嵌入，以取代粘接質體3Ε11 (序列辨識編號：llL 驗基32162-35620)之3.51(：1)£^〇111片段中的天然形式^^91 1-爲 el片段，選殖於質體pBhescHpt SK-(Stratagene)内。 _ -45-_____ 本紙張尺度適用中國國家標準（CNS ) A4規格（X297公酱） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（43) 然後將變異種的&oRl片段移轉入結合質體pDAB 1523(第 5圖），這是一個含有 基因之 pOJ260的衍生物，該基因提供可反選汰的鏈黴素-敏感的 表型（Hosted & Baltz，1997)。以 Matsushima 等人的方法 (1994)，將得到的含有變異種五coRl片段的質體從大腸桿 菌S17-1 (Simon等人，1983)結合入SS15，它是一種自然 的史賓多泡酵母菌菌株NRRL1853 8抗鏈黴素衍生物。（& 菌株NRRL 18538自然的抗鏈黴素衍生物可以报容 易地以熟悉的文獻分離。）以異羥基洋地黃毒配質標誌探 針的沙頓雜交，顯示抗阿布拉黴素外結合物含有ER2區域 天然的形式和變異種的版本（Boehringer Mannheim)。它們 也含有rpsL基因，因此，在含有鏈黴素 150mg/L 的BHI 瓊脂（Difco，Detroit，MI)，它們生長情況 不好，而無法得到有氧菌絲。如同它們在含有鏈黴素150 mg/L的BHI瓊脂的生長得到白色，有氧菌絲而造出自然的 抗鏈黴素回復變異體。沙頓分析法顯示這些菌株不再含有 rpL基因，或任何其他 pDAB 1523 序列。 有一些菌株失去了整個史賓諾辛生物合成基因群，包括 ER2區域及pDAB 1523。在其他菌株中，pDAB 1523序列 與變異種ER2區域一起被切割，再產生母體基因構造。在 抗鏈黴素菌株的第三形式，pDAB 1523與天然形式ER2區 域被切割，該位置只剩下變異種的版本。發酵後，這第三 形式的菌株產生一種新穎的代謝產物，可用液體層析法以 C18管柱與史賓諾辛分離（ODS-AQ，YMC，Wilmington， -46- 本紙張尺度適用中國國家標準（CNS ) A4g ( 210X297公釐） -------叫---^#1-----—1T------ (請先閲讀背面之注意事項再填寫本頁} A7 1237058 B7 五、發明説明（44 ) NC)，流動相為乙腈：甲醇：2%醋酸銨（44 : 44 : 12)。這 個新的部份以電子喷霧離子化法和同步質譜分析法 (Balcer等人，1996)，使用三級四元質譜儀（TSQ700， Finnigan MAT，San Jose，CA)分析。它具有預期的 C18 : C19-脫水史賓諾辛A的性質，質量為729.5道爾頓，得到142 道爾頓forosamine片段。我們得到結論，編碼PKS區域的 DNA修飾得到新穎的發酵產物的生產。 實施例6 NRRL 1853 8以鼠李糖生物合成基因轉形增加史賓諾辛A 和D收率 含有鼠李糖生物合成基因的片段獨立地選殖於結合 載體pOJ260 (Biemian等人，1992)。得到的質體列於表 21° I : 1: 碡丨 (請先閱讀背面之注意事項再填寫本頁) 訂 表21 質體 基因 pDAB 1632 Stt pDAB 1634 gdh +kre pDAB 1633 epi -線 經濟部智慧財產局員工消費合作社印製 以Matsushima等人的方法（1994)，將各質體從大腸桿 菌S17-l(Simon等人，1983)結合於史賓多泡酵母菌NRRL 18538。選擇抗阿布拉黴素外結合物，假設該外接物含有 以同系重組將質體同化作用入染色體，並進行發酵（表 22)。 _-47- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 A7 B7 五、發明説明（45 ) 表22 以鼠李糖基因轉形NRRL 15328衍生物之史賓諾辛生產 菌株 複製之基因 A+D ( ug/ml) 實驗、1 實驗2 NRRL 18538 無 344±39 405±25 NRRL 18538/1632-1 gtt 410土21 418 ±38 NRRL 18538/1634-1 gdh -\~kre 351±27 360土21 NRRL 18538/1633-1 epi 318+29 315 士18 此實驗數據為平均值+95%可信度範圍。 以gii或叩卜或gi/A和組合轉形的NRRL 15328衍生 物中，史賓諾辛收率量沒有同時增加。 含有gii和gi/A+A:re基因的片段混合於一質體。分離含 有混合 和 Are基因（pDAB 1654和 pDAB 1655)的二 質體，以Matsushima等人的方法，從大腸桿菌S17-1. (Simon 等人，1983)結合入史賓多泡酵母菌NRRL 18538 (1994)。 選擇抗阿布拉黴素外結合物，並進行發酵（表23)。 表23 I---^---；----^#1------1T------ (請先閲讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 以鼠李糖基因轉形NRRL 15328衍生物之史賓諾辛生產 菌株 複製之基因 A+D ( [ig/ml) 實驗1 實驗2 NRRL 18538 無 109土9 133±36 NRRL 18538/1654-2 Gtt、gdh反 kre 323土19 244±34 NRRL 18538/1654-5 Gtt、gd 反 kre 571±23 412±61 NRRL 18538/1654-6 Gtt、gd S^kre 577+17 425+51 NRRL 18538/1654-1 1 Gtt、gdh 反 kre 587±23 426±55 NRRL 18538/1655-1 Gtt、gdh反 kre 501土20 395±59 NRRL 18538/1655-3 Gtt、gdh反 kre 537±27 421±63 NRRL 18538/1655-5 Gtt、gdh 反 kre 529±21 428土47 NRRL 18538/1655-12 gtt、gdh^Lkre 526±26 401土60 _ -48- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 B7 1237058 五、發明説明（46 ) 此實驗數據為平均值+95%可信度範圍。 在以g"、g办和虹e基因轉形的NRRL 15328衍生物， 觀察到有意義的史賓料收率增加。這可能是因為同時增 加ga和基因產物的量，克服了速率限制2NDp_4___ = 脫氧-葡萄糖的供應，它是生物合成必須的酵素（參考第工 圖）aNDP-4-酮-6-脫氧_葡萄糖中間產物的供應越多，會 得到更多鼠李糖和forosamine二者的生產，因此更有能力 轉形配質成為史賓諾辛A+D。與脫氧糖類的供應限制nrrl 18538的史賓諾辛生產的假說一致，許多變異種在高層次 阻斷forosamine的合成或加成聚集pSA。相對於史賓諾辛 A或D的需要二個脫氧糖類，因為它只需要一個脫氧糖類， 可製造更多的這些中間產物。 本發明並不限制於含有本發明史賓諾辛基因的特別 載體，更包含所有用於將該基因引入重組型宿主細胞載體 内的生物合成基因。 另外，由於基因編碼的簡併性，熟悉文獻者會熟悉 製備編碼與天然基因序列相同的或功能性相同活性Dna 序列的合成方法。同樣的，熟悉文獻者會熟悉修飾或改變 基因序列，製備新的編碼如天然的序列相同的或實質上相 同的聚狀活性序列的技術。因此，本發明也包含這些這些 基因合成變異體和修飾的形態基因和表現產物。 在此’將所有上面提及的專利文件和發表文獻合併 作為參考資料。 ---- -49- 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) -訂 線‘ 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（47 ) 參考文獻 1. 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Rosteck & K.L. Sutton (1997). “Polyketide synthase genes.” EPA 0791655. 10. Don，R.H·，P.T. Cox，B.J. Wainwright，K. Baker & J.S· Mattick (1991). "Touchdown' PCR to circumvent spurious priming during gene amplification，，’ iVwc/. Xczd 及從 i4008. 11. Donadio, S., J.B. McAlpine, P.S. Sheldon, M. Jackson & L. Katz(1993). uAn erythromycin analog produced by reprogramming of polyketide synthesis,Proc. Natn. Acad. Sci. USA 90: 7119-7123. 12. Donadio, S. & L. Katz (1992). 'Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythrae^ Gene 111: 51-60. 13. Donadio, S., M.J. Staver, J.B. McAlpine, S.J. Swanson & L. Katz (1991). “Modular organization of genes required for complex polyketide biosynthesis/5 Science 252: 675-679. 14. Fish，S.A. & E. Cundliffe(l997)· “Stimulation of polyketide metabolism in Streptomyces fradiae by tylosin and its glycosylated ipTQCUvsors^ Microbiology 143: 3871-3876. 15· Geistlich, M., R. Losick, J.R. Turner & R.N. Rao (1992). ^Characterization of a novel regulatory gene governing the expression of a polyketide synthase gene in Streptomyces ambofaciens," Mol. Microbiol. 6: 2019-2029. 16. Hosted, T.J. & R.H. Baltz (1997). 4<Use of rpsL for dominance selection and gene replacement in Streptomyces roseosporus'\ J. BacterioL 179: 180-186. 17. Inouye, Μ., H. Suzuki, Y. Takada, N. Muto, S. Horinouchi & T.
Beppu (1994). UA gene encoding mycinamicin III O-methyltransferase from Micromonospora griseorubida^ Gene 141: 121-124. _；_-51^_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） I — I；-II---考----—1T------S (請先閲讀背面之注意事項再填寫本頁) 1237058 A7 B7 五、發明説明（49 ) 18. Jiang, X.M., B. Neal, F. Santiago, S.J. Lee, L.K. Romana & P.R. Reeves (1991). "Structure and sequence of the rfb (O antigen)gene cluster of Salmonella serovar typhimurium (strain LT2)/5 Mol. Microbiol 5: 695-713. 20· Kirst, H.A., K.H. Michel, J.S. Mynderse, E.H. Chio, R.C. Yao, W.M. Nakatsukasa, L.D. Boeck, J.L. Occlowitz, J.W. Paschal, J.B. Deeter & G.D. Thompson (1992). ^Discovery, isolation and structure elucidation of a family of structurally unique, fermentation-derived tetracyclic macrolides. in synthesis and Chemistry of Agrochemicals ///,D.R. Baker, J.G. Fenyes & J.J. Steffens, eds. Washington, DC, American chemical Society: pp. 214-225.
21. Linton, K.J., B.W. Jarvis & C.R. Hutchinson(1995). ''Cloning the genes encoding thymidine diphosphoglucose 4,6-dehydratase and thymidine diphospho-4-keto-6-deoxyglucose 3,5-epimerase from the erythromycin-producing Saccharopolyspora erythraeaT 22. Liu, H.W. & J.S· Thorson( 1994)· “Patheays and mechanisms in the biogenesis of novel deoxysugars by bacteria,,5 Ann Rev Microbiol 48: 223-256. 23. Matsushima, P., M.C. Broughton, J.R. Turner & R.H. Baltz(1994). "Conjugal transfer of cosmid DNA from Escherichia coli to Saccharopolyspora spinosa: effects of chromosomal insertion on macrolide A83543 production,Gene 146: 39-45. 24. Ruan，X·，et al.(1997)· “Acyltransferase domain Substitutions in Erythromycin Polyketide Synthase Yield Novel Erythromycin Derivatives,J. Bacteriology 179, 6416. 25. Siggard-Andersen, M. (1993). "Conserved residues in condensing enzyme domains of fatty acid synthases and related sequences, ’’ Protein Seq, Data AnaL 5: 325-335. 26. Simon，R·，U· Preifer & A· Puhler (1983)· “A broad host range ________152JI_ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐) I — -_丨 (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（5〇 ) mobilization system for in vive genetic engineering: transposon mutagenesis in Gram negative bacteria/5 Bio/Technology 1: 784-791. 27. Solenberg，P.J. & S.G. Burgett (1989). “Method for selection of transposable DNA and characterization of a new insertion sequence, IS493, from Streptomyces lividans^ J. Bacteriol. 171: 4807-4813. 28. Strobel, R.J. & W.M. Nakatsukasa(1993). ''Response surface methods for optimizing Saccharopolyspora spinosa, a novel macrolide producer,^/. Ind. Microbiol. 11: 121-127. 29. Thorson, J.S., S.F. Lo & H. Liu(1993). ''Biosynthesis of 3,6-dideoxyhexoses: new mechanistic reflections upon 2,6-dideoxy, 4,6-dideoxy, and amino sugar construction,J. Am. Chem. Soc. 115: 6993-6994. 30. Weber, J.M· & J.B· McAlpine (1992). “Erythromycin derivatives,” U.S. Patent 5,141,926. (請先閲讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 準 標 家 國 國 中 用 適 度 一尺 I張 紙 53 I釐 29 1237058 at B7 五、發明説明（） 序列表 (請先閱讀背面之注意事項再填寫本頁) (1) 一般資料： (i)申請人：理察H·包爾特 瑪莉C.布魯頓 凱斯里P.克洛佛德 克理西納•摩西莫度里 唐納德J.孟羅 珮蒂J.崔德威 珍R.脫爾諾 克理夫•渥德羅 (ii) 發明名稱：用以生產史賓諾辛(SPINOSYN)殺蟲劑的生物合成基因 (iii) 序列數目：39 (iv) 聯絡地址： (A) 聯絡對象：陶氏農業科學公司專利部 (B) 街名：茲艾斯維爾路9330號 (C) 城市：印地安納波立斯 (D) 州名：印地安納州 (E) 國別：美國 經濟部智慧財產局員工消費合作社印製 (F) 郵遞區號：46268 (v) 電腦可讀之型式： (A) 媒體型式：電腦磁碟片 (B) 電腦：ffiMPC可相容的
(C) 電腦：PC-DOS/MS-DOS (D) 軟體：Patentln Release #1.0, Version #1.30 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） (Vi)目前申請資料·· (A) 申請案號：09/36987 (B) 申請日：1998年3月9曰 (C) 分類： (viii) 代理人資料： (A) 姓名：唐納德R.史都華 (B) 註冊號碼·· 28,479 (C) 參考檔案編號：50,608 (ix) 聯絡資料： (A) 電話：（317)3374816 (B) 傳真：（317)337-4847 (2)序列辨識編號:1之資料： (i) 序列特徵： (A) 長度：80161個氮鹼基對 (B) 型式：核酸 (D) 股型：雙股 (D)拓樸學：線形 (ii) 分子形式：DNA (基因組的） (xi)序列敘述：序列辨識編號:1 GATCTCCATG AAGCTCAACG TAGGCACX3GA CX3GTCAGGTG GACTGGGTGA TCGCCCGCX3A 60 CCTGCTGGCC GACX3GGCTGA TCGCCX3AGGC AGGCGAAGGC GATGTGCX3GA. TO3GCCCTCG 120 ACGGGGTTTT CCXX3GGTTGG TCGTGATCGA GATGAGCTCG CCGTCGGGGC AGGCCTCCTT 180 CX3AGGTGAAT GCTGACCAGC TTGCGGACIT CTTGAACX3AC ACCTACGACO TGGTCGAACC 240 TCGTGATGAA CACCGGTGGA TGAACGTCGA CGAGGTGCTG AGCCAGCTGC TCTCGCCAAC 300 CTCTAATCGC CCAGCTCTCC CGAAGCGCCG CACGCCAAAG CGCTGGCTGC GGGACCTGGC 360 GGCGCTGAAC ACCX3CCACX3C TGTGTCTCCX5 AGCTCCAGCT GGACCACGTC GGTGCCX3TGC 420 本紙張尺度適用中國國家標準（CNS ) A4規格（21 OX 297公釐） ； ： -------IT------$1^— (請先閲讀背面之注意事項再填寫本頁) 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） GCCCGGCTCG GTCAGGCCXSA AGGTGCTGA.T CTTCTCCAGG 03CGCCA.TCG GCGCA.GGAAG 480 CGCTGCTTCT GCTCCCGCCX3 CAGTACCGTC GTGTCATGGC CACGGACAGC TTCX3ATTCCT 540 CGAAGCTACA GGCGGCCGTG GCATCGAGCG TCGCGTCGTC CGTCTCGGAA GTCAGCCGAG 600 ACGTCTACAC GCACCTGATT ACCGAGGCTC OSC^GTTGCG AGCCX3ATGAG ATCX3TCCTCA 660 GCATTCTACG GACGAGTGTT GAGGAAAATA TCGCCACA.TT GCCGCACGTT CTCXSAATTCG 720 AGATTCCGTT GGGATATTCG CCGGGTCCTG CTGCGGTGTT GGAGTATCCG CGACGACTGG 780 CGAAACATTT CCATCAACGC GCTGATCAGG GCCAACCXSCA TOSGGCACTT CCX3CTTCCTG 840 TAGTGATGCC TCGACGAGAT CCGCCX3CCAA TGCGCCGACG AGGCCGTATC CGCAGCGACC 900 ACGCAACXSAA TGCTCGCAAC CAGCTTCGGC TACATCGACC GCXSTCACGGA GCAGATCGCC 960 GAAACCTACC AGCTCGAACX3 GGACCGCTGG CTCCTGGCGA CX3GGACX3GCC GTGAGGTCTC 1020 TGCGGCATCC GCA.TAGCGTC TTCTCCCX3CT GAGGCACATG AGGTGTTGCG OXX^TCGTT 1080 TCCGGCAGTC GCACGGCATT CGTCCTAGCT GCGGGCAATT GAGGGAGCGA AGATITAGAG 1140 GAGTGTGGCC ACGCGGACCA AGCCX3GCGAG TGCIO3GGAG CC3GCTGTGGG GCGGCCAGGC 1200 GATGACTGTC GTCACGTCCG GCGCGTCTAG AACCGGTACG GCGGCGAGGC CTTCGAGCAG 1260 GTTGACGCX3A CTGGATTCX3G GCATGACCAC GGTAGTGCGG CCGAGTGCX3A TC^TTTGGAA 1320 CAGTTGCGTC TGGTTGCGTA CTTCCACGCC GGGGCCATCT GGATAGACGC CGTCGGGGCC 1380 GGGCCAGCGC GCAAGCX3GGA GATCCGGCAG TGMCTGACA TCCGCCATCC GTACATGGGG 1440 CTCX3CTGGCA AGCGGATGCX3 AGGTCGGAAG AATGGCGACT TGTTOCTCGG TGTTCAGAAT 1500 TTCGATGTCG AGTTCGGCCO TCX3GGTCGAA GGG1TGATGC AACAGCGCCA CGTCGGCCCG 1560 GCCGTCATGC AGCX3TTTTCT GGCX3CTGGGA TTCGCAGAGC AGCAGGTCX3A CGGCCACGGC 1620 TCCCGGCTCG GCGGCGTACG CGTCGAGCAA CTTCGCCAGC AGCTCACCGG AGGCGCCGGC 1680 CTTGGCAGCC AGGACTAGCG AGGGCTGGCT CX3TCGCX3GCA CGCTGGGTGC GTCX3CTCGGC 1740 TGCTGCCA.GC GCX3CCX3A.GGA TCGCCCGGCC TTCGGTCAGC AGCA.1TGCCC CGGCTTCGGT 1800 GAGCGAGACT TTGCX3GCTGG TGCX3TTGCAG CAACACX3ACT C03AGTCGTT GCTCX3AGCTG 1860 GGCGATCGTC CGCGACAGCG G03GCTGGGC GATGCCCAGG CGCTGGGCGG CCCGGCCGAA 1920 GTGCAACTCC TCGGCGACTG CAACX3AAGTA CCX3CAACTCC CGCGTCTCCA TCCGTOSAGC 1980 CTACCX3CTGA TTCATATCAG CTGGGTATCG GTGTGAGACC TAGATGGTGT IX3GTTCCCCX3 2040 CCGGTTTCGG GCCACX3CTAG AAAGCATGAG CX3AACAGACG ATTGCACTGG TCACCX3GCX3C 2100 AAACAAGGGA ATCGGATACG AGATCX3CGGC CX3GGCTCGGC GCGCTGGGGT GGAGCGTCGG 2160 AATCGGGGCA CGGGACCACC AGCGCGGGGA GGATGCCX3TG GCGAAATTGC GTGCGGACX3G 2220 CGTCGATGCG TTCGCGGTAT CCCTGGACGT GACAGACGAC GCGAGCGTCG CGGCTGCTGC 2280 GGCTCTGCTC GAGGAGCX3CG CCX3GCCX3GCT CX3A.TGTGCTG GTTAATAACX3 CCGGCATCGC 2340 CGGGGCATGG CCX3GAGGAGC CCTCGACCGT CACACCGGCG AGCCTCCX3GG CX3GTGGTGGA. 2400 GACCAACGTG ATCGGCGTCG TTCGGGTTAC CAACGCTATG CTGCCGTTGC TACGCCGCTC 2460 ----^------——-----IT------- (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（) CGAGCGCCCG CGGATCGTCA ACCAGTCCAG CCACGTCGCT TCCCTGACCT TGCAAACCAC 2520 GCCGGGCGTC GACCTCGGCG GGATCAGCGG AGCCTACTCA CCX3TCGAAGA CX3TTCCTCAA 2580 CGCGATCACC ATCCAGTACG CCAAGGAACT CAGCGATACC AACATCAAAA TCAACAACGC 2640 CTGCCCCGGC TACGTCGCGA CCGACCTTAA CGGCTTCCAC GGAACCAGCA CGCCGGCAGA 2700 CX3GTGCCAGG ATCGCCATTC GGCTCGCCAC GCTGCCAGAC GACX3GCCCGA CGGGAGGCAT 2760 GTTCGACGAC GCCGGGAATG TGCCCTGGTG AGGCGCTCAG TCGGCGATGG TGO^VTCGAA 2820 GTCGGRGAGG CIO3CIO03A CCGGGTACX3C CGAACAACAC CT3TTCCTGT GGGTACX3GAT 2880 GTCGGCCTTC GCCGTCTCGG TCATTGACAA CCTGTACTTC GGGCGCCGTT ACCGCCGGTG 2940 CGCCGCGGTT GCCTGGCGAC ACTGGGCCAG CCGTGGCTCA CCGGCGGCTT AGGTCAGGCG 3000 TGGGCGGTTG CCAGCATGGC GGGTGCGGCT TTGCGTAGGT CGGGTAGGCG CATCCGGCGC 3060 GGGAGCCGGT CGAGTTCTTC GC03A.TGGCC GGTGCTTTGG GGCTGCICAG GAGCCGAACA 3120 CCTCCCAGCC GCAGGTGCCG GGCTGAACCG AGTGGTTCTC GTCGGCTCGG ATCACAACGT 3180 CTGCCGGAAC AGCTGCGGCG AGGTGGTCGC AGATTCGAGG CGGGATCGTC CTCGGCGACC 3240 TTGCCX3ACGA TCX3CX3GCTAG GGCCCAGGGC TTCGTCGACC TGGTTGGCAC CTAGATCACG 3300 ACGGTCAAAA CTTGCCXSGCA TCAGAQACGA TCGAAGTGAT CCCGGGTCAC GTCGGCTTAT 3360 CGGTCGAGTG AGTCCCGGGG CCTGCCCAGC CAGGTCTTGC GTCGTTGTTC CGGGCTCAGT 3420 TGCGGATTCC GACX3AACAGG CCTCGGCCOT TCGGTGCTCC AGGAAGGTAT TCCX3CGCX3GA. 3480 TCCCTGCGTC TTCGAGCX3CX3 GCX3GTGTACT CX5TCCTCAGT GAACAGCGAG AGGATTTCGA 3540 ACTCTGTGAA GTCCCGGATC CCX3GTGGGTT CGGCX3ACTGT GTAGCX3GACX5 GTCATCCGGC 3600 TCGTACX3GCC CTCCAGGACC GAGTGCGA.TA GCCGGCTGAT CACCCGCTCX3 CCGTGGTGCG 3660 CX3ACX3GCTCC GGTGACX3AAC CCGTCGATGA ACTTGTCGGG AAACCACCAG GGTTCGATGA 3720 CCX3CGA.CTCC ACCAGGGGCC AGGTGCCGGG CCATGTTCCX3 CGTCACX3CX3T CX3CAGGTCGT 3780 CAACGGTCCG CATGTAAGCC GCX3GTAAAGC ACaGGCAGGT GA.TGACX3TCG AATGGCTCGC 3840 CGAGGTCGAA ATCGCGGATG TCACCGATGT GAATCGGTAC CTCAGGGACT CGTCTGATCG 3900 CGATCTCCCG CATCGCATCG GACAGTTCAA GCCCCGCGAC CTTCGCGTAT TCGGCACGGA 3960 ATCXX^CTAG GTGCGCCCCG GTCCCACAGG CGACX3TCGAG TAGGGACTGT GCTTCGGGCA 4020 GCCTCGTGCG TA03AGCTGG ACTACTTCCC 03GCCTCGGC TGCCCAGTCC CGGCCACX3CX3 4080 CGGAGTGGA.T CX3CX3TCGTAG ATGTCGGCAT GATCTGGGCT GTATACCGAG GAGGTTTCTG 4140 CX3AATGTGTC GCTCACGCGC GACATCCTCA CTITCGGAGT GGI^TCTET GGCTGA.TGTG 4200 CTGTTCGACG GCCTTCTGGA ACTCGTCAGC CACCGTGCGC ACCTCGGCGT CGTCAAGGCT 4260 TCGGTGCAGT GGTAGCAGGA GTGTTCTGCG GCAGGCGTCC TCCGCAGAAG GCAGCTTGCA 4320 GTCCX3CGCGG TAGATGGGGA CCTTGTGCAG GGGCX3GGTAG 03GTAGCTCG TGTAGATGCC 4380 GCGTTCCAGC ATITCCTGCG CCACCTGGTC GCX^TCTCC GGAGCCAGCT GGACCCAGTA 4440 GAAGTAGTGT GACX3AGACX3T GCCCATCCX3G TAGCX3TCGGC GGTAGGAGGA CACCCX3GCAC 4500 ----11-^---Φ,----—1T------^#1(請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） ATCGGAAAGC AACCGGTCGT ACTGCGTAGC GATTTCTCTA CGCCTGTTGA TGAATTCTGG 4560 CAGTTTGCGC AGCTGCACGC TGCCAAGCGC TGCCGTCATG TCGTTCCCGA TCAGCCGCTG 4620 GCCGATGTCT TCX3ACGCGAA TATCCCACCA GCGGTTGGAA GACTTGGCCG AATCGAATCC 4680 GCTCATCTGC TCAAGACCGT GGTAGGCGAG TCGTCTTGCX5 CX3GTGCGCCA GCTCCGGATC 4740 CX3CCGCGTAG AACATGCCCC CATCCCCGGT GACCA.GGA.TC TTCA.TCGCAT CGAAACTCCA 4800 CGTGGCCAGG TCACCAAAGG TTCCX3CAAGC GGTGCCGTGC ACX3GACGATG CCACCX3CX3CA 4860 GGCX3GAGTCC TCGATGAGCA TG^GGCCCTT TTCACGGCAG AAATCGGCGA TCX3CX3GTGAC 4920 TTCTCCCX3GC GATCCTCCAT AGTGGAGCAG CAATACX3GCC ITGGTCGCCG GCGTGATGGC 4980 CCTCGCCACA TCATCCAGCG TGGGGTTCAA CX3TCCGGGGG TCGACGTCX3C AGAACACCGG 5040 GCX3GGCACCG GAGGATGCGA TGGCGTTGGC CX3CCGCCACX5 AAGCTTATCX3 AAGGAAGTAC 5100 CACGTCX3TCX3 CCTGGGCCX3A GGTCGAGCAC CTGCACGGTA AGGAACAGCG CGGCAGTCCC 5160 CXSAGTTGAGG AACACGACCT GTTCX3GGATC CACTCCCAGG TGGTGGGCGA ATTO3GCCTC 5220 GAACGTCCGG GTGCGCGGCC CGAGCCCGAT CCAGTTGGAG GCGAACACCT CCGCGATCGC 5280 GTCGAGTTCT TCGGTGCCGA GGATCX3GCTG GTGCAGGTIO ATCACGTTGC TGAAATCCTC 5340 CGAGATGCCG CCATGCTGGA TGCTAGGAAC TCTTGGCCAC GAATTCAGCG ATTGATTCGA 5400 CGACGTAGTC GATC^TTTGG TCCGTTATGC CTGGGTAGAC GCCX3ACCCAG AAGGTTCGGT 5460 CGGTGACGAT GTCGCTGTTG GTGAGCGCGT CGGCGATCCG GTACCX3CACC TCCTCGAAGG 5520 CCGGGTGCCG GGTGATGTTA CCGCCGAACA GCAGTCGGGT GCCGATGTTG CGGGATTCCA 5580 GGAAGTTCAC CAGGGCX3GCA CGGGTGAACC CGGCX3TCCGC ACTGATGGTG ATCX3CAAACC 5640 CGAACCAGCT CGGGTCX3CTG TGCGGTGTGG CTACCX3GCAG O^SCAGGCCC GGCAACCCGG 5700 ACAGCCCTTC GCGCAACCGT CX3CCAGTTAC GGCGGCGTGC CGACCCX3AAT GCGGAAATCT 5760 TCCTCAACTG GCTCAGCGCA AGTGCGGCCT GCAGGTCGGT GGTCITGAGG TTGTAACCGA 5820 CX3TGGGAGAA CGTGTACTTG TGGTCGTAGC CCGGTGGAAG GGTACCGAGG TGGTAGTCGA 5880 ACCTCTTGCG GCAGGTG1TG TCCACGCCX3G GCTCXSCACCA GCAATCCCX3T CCCC^GTCAC 5940 GCAGCGACTC GATGATGCGA GCCAATTCCA GGCTGCCX3GT CAACACX3CAG CCACCCTCGC 6000 CGCTGGTGAT GTGATGGGCA GGATAGAAGC TGACCGTTGT CAGGTCGCCG AAGGTTCCX3G 6060 TCAGCCX3TCC CCX3GTAGGTG GATCCCACCG CATCACAGTT GTCTTCX3ACX3 AGGAACAGCT 6120 CGTGTTCm TGCGATCTCC GCGATTTCGT CAGCGGCGAA GGGGTTGCCC AGGGTGTGCG 6180 CCAGCATGAT GGCTCGCGTC CGTTCCGTGA CGGCGGCCTT GATGCGGTCT GGCGTTGCGT 6240 TCTAC3GTGCC CAGTTCCACG TCGACGAATA CCGGGACGAG TCOTTTTTGG ACCX3CCX3GA.T 6300 TCATCGTCGT GGGGAAGCCX3 ACCX3CCGCAG TGATCACTTC GTCX3CCGGGC CGCAGTCGTG 6360 CCTCGCCX3AG TTTGGGGGAG GTAAGCGAAC TCAGTGCCAG G^GATTGGCC GACGAACCGG 6420 AGTTGACXSAG ATGAGCCTTG CGGAGGCCGA AGAAGCGGGC GAACTCGCTC TCGAATCX3CC 6480 GTCCATTCCC GCCCGCGGCG ATCCGGAGCT CCAGCGCGGC TTCCACCAGT GCCACCCGGT 6540 -58 - ^ 訂 線 ~ (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 1237058 at B7 五、發明説明（） ： Γ---释 — (請先閲讀背面之注意事項再填寫本頁)
線I 經濟部智慧財產局員工消費合作社印製 CGTCCTCGTC GAGCACGGCG CCCGATGGCC GGATCGGCGT CGATCCAGCC ACGAAGGTCG 6600 GGGATTCCTG TTCGCGGTGG TAATCX3CGTA CGGATGCCAA TATCCGGTCC ITGGCATCCG 6660 GCACCATCTC AGTAGCGGTA GCGCAAGTGT CGTCACACGA AGTCACTCTG GCGCGCCCTT 6720 TCCCCAGCGC TCTGGTTTTC CGGCTCTGCA TGCAGGCGAC GATCAGTCTT CGCGCCTTGC 6780 CTTCAGGAGA TGAGCGATGC CCGTGGCGAA TCGCX3TTATG AOHX：CCAGC GGGACAGTGT 6840 GCTGTCTCGG CGCCTTACAC CTTCCTGCCC TGGTTCGATG CGGTGCX3GGA CATCAGGACA 6900 GCGGAGCAAG GAGAAGCGCT CATTGACTCA QAAATCCTCG ATCTACCCGG CACACCCX3AC 6960 TCGGTAGAGC CCAGGCTAGC GGGAACGACC TGCTCGCGCT TGTCAAGATC GCTACCATCA 7020 CCTGGAAGGC CTAAGATTTG GCTTGCGAAA GCGGCGTITC CCGGGGGATA TCAGAGATIT 7080 CTGTGMTCT TGGCATGCTT CCCGGGTGTT CAATTGCGAT CGGAGAGTTC ATGCGTGTCC 7140 TGTTCACCCC GCTGCCGGCG AGTTCX3CACT TCTTCAACCT GGTGCCJGTIO GG3TGGGCGT 7200 TGCGTGCCX3C GC3GGCACGAG GTCCX3TGTCG CCATCTGCCC GAATATGGTG TCX3A.TGGTCA 7260 CCX3GAGCAGG ACTCACCGCG GTTCCCGTCX3 GCGACGAGCT CmCCTCATC TCCTTGGCX3G 7320 CCAAGAACGA ACTCGTTCTC GGCAGCGGGG TCTCGTTCGA CGAGAAGGGG CGGCATCCGG 7380 AACTCTTCGA CGAGCTGCTG TCAATCAACT CCOGCAGAGA CACGGACX3CC GTGGAGCAAC 7440 TCCACCTTGT GGATGACCGA TCX3CTGGACX3 ATCTCATGGG GTTCXSCCGAG AAATGGCAGC 7500 CTGATCTCGT TGTGTGGGAC GCTATGGTGT GTTCX3GGGCC AGTTGTGGCG 03AGCGCTCG 7560 GCGCACGACA CX3TGCGGATG CTCX5TCGCCC TCGATGTGTC GGGGTGGCTG CGGTCCGGTT ' 7620 TCCTCGAATA CCAGGAATCG AAGCCGCCTG AGCAGCGCGT CGACCCGCTC GGGACGTGGC 7680 TGGGA.GCX3AA GCTCGCCAAG TTCX3GAGCCA CX3TTCGATGA AGAGATCX3TG ACGGGCCAA.G 7740 CX3ACCATAGA TCCXSATTCCA. TCCTGGATGC GCCTGCCTGT GGACITGGAC TAC^TCTCGA. 7800 TGCGTITCX3T GCCX5TACAAC GGTCCX3GCGG TGTTGCCGGA GTGG1TGCGC GAACX3ACCGA 7860 CGAAGCCGCG 03TCTGCATC ACX3CGCGGGC TGACCAAGCX3 GCGGCTGA.GC AGGGTGACCX5 7920 AACAGTACGG GGAGCAAAGT GACCAGGAAC AAGCAATGGT GGAAACSGTTG TTGCGCX3GCG 7980 CGGCCAGGCT CGACGTCGAG GTGATCGCCA CCITCTCTGA CX3ACX3AAGTA CGGGAGATGG 8040 GGGAGTTGCC CTCXSAACGTC CCGGTCCACG AATACGTACC GCTCAACGAA CTCCTGGAGT 8100 CGTGTTCAGT GATCATCCA.T C^VTGGCTCGA CGACXSACGCA. GGAAACCGCC ACX3GTCAACG 8160 GCGTACCX3CA GTTGATTCTC CCTGGGACCT TCTGGGA.CX3A. ATCTCGTAGG GCX3GAGCTCC 8220 TAGCCGATCX3 GGGAGCCX3GT CTGGTCCTCG ACCCCGCX3A.C GTTTACCGAA GA.CGACGTGC 8280 GAGGTCAGCT GGCCCGCCTG CTCGA.CGAGC CX3TOJCTCGC TGCCAACX3CX3 GCGCTGATCC 8340 GCCX5TGAAAT CX3AGGAAAGT CCCAGCCCGC ACGACATCGT TCCACX3TCTG GAAAAGCTAG 8400 TTGCCGAACG TGAGAACCX3C CXX^CTGGGC AGTCTGATGG CCATCCGTGA GCAACX3TGTG 8460 GCCGGAAACA TGGACX3CCX3G GGTTTGGCAG GTGTTCATCG C^TTGCGTC GACTCGGATT 8520 CCGCCGTGAC CGGGACGATG CCAGGCGAGT CCCGAAGTCA GATTCTTGTC CAGAATCGTC 8580 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
CAATGGGGTG TTGATCTCCC CAGAGGTTTG CGCTCCAACC GATTTCCGAC GCGCCCGCTC AGCAACX3ACT ACCGTGCGGT CGAGACATAC CGCTGTGCGC GGTCGGTTCC CCGATCACCG TGCTGGTGGT AGATGCCGAG CCGAAGGTCA GGCX3GAAGCC TGGCGAGAGC ACACCX3AGGC CGTGGCCGAC GCAT1TCTTC ATGACCGAAC GCCAGGACGA GGTGCTCGCG GTCCTTACGG TCGATGATCC TCGCCAGGCC GCTGGACCAG ACCGCGACGC ATCX3TCACX3G CAGTGA.GGGA ITGGGCATGA CTGCGCCX3CT CGGCAGCAAC AACACX3CX3GC ATGGCATGA.T TCCGACCACX3 GAGTTCCACT GCIOGCTCGC CX3ATCX3GCTG GCTTCX3AGAC CAATCGCATC CCGTTCGACC GCCTGTCGAA ATGGAAATTC CGGAGAACCT GGTTCATGCC GACGGTAGGT TCTTCACX3GT CCAACTATGG CX3CX3GCACCC AGCTGGCACC AGCCGA.TCAT CAACCAGGCT TCCTCGGCAT TCTCGTCAAG GAGATCGACG GCGTGCTGCA CTGCCTCATG TGGAACCX3GG CAACGTCAAC GTCCTGCAGC TCTCGCCX3AC GGTTCAGGCA ACTACACGCA GGCA.CACCGT GGCAGCGTTC CGCCCTATGT GGACTACTTC GCCX3CGGCCX5 CGTGCTGGTA GACX3TGCTCC AGTCTGAACA GGGGTCCTGG AGCX3CAACCX3 GAACATGGTG GTGGAAGTCC AGGAGGAAGT GCCAGTCCTG GCTGGTTGAC GCTCGGCCAG GTGCIOSCTC TCCTTCGTCA GGACAACATC ACACCCGGAC GGTGCTGTCT TGCATCCCGT TCCACGATTC CGCCACCGGA CCGCCTCGGA GGAGCCCTTC CX3ACAGGCGG TGGCCAGGTC GCTCTCGCAC CGTCGAGTAT CTCCX3AGGCG GTCGGTTGGT TCX3AGGAAGC CAAGGCCCX3C GGGCAACGCG CGTTCCX3CTG AGCAGGGTCG ACAAGTGGTA TCX3CACCX3AT CCCACCAGGA CGGCAAGTAC TTCGCGGTGA TCGCGGTGTC GGTGTCCX3CG AGGTCGCCAG CTGGACX3CAG CCGATGATCG AACCX3CGAGA ACAAGGTGAG TGGTCAAGCG GATCGGCGGA GTGCTGCACG GTTTGGTCCA ATAAGTGGAC TGCGGAAATC GCTCCCACGG TCCA.G1X3CA.G TGTGGCCAAC CCCCGTCGAA CGACTGGCCG CCGTTCTTGG ACGACGTGCT CACCGCCGAT TGCGGTACX3A ATCX3ATCCTG TCCGAAGAA.G GCGGTCGGTT CTACCAGGCX5 ACCGGATCAT CGAGGTGCAT GAGGACTTCG CGGCACGACC TCCCAGCGAC TGACTTTGGG ACAGTTGGGC GAGCTGCTCC GGAGCACCCA CTTCTTGAAC GCAGCTTGGT CX3CCTCCCTG CATAGCTTGT GGGCGTTGGG GCGATGACCA AAAGCCGGTG CGCATCGGTG TGCTCGGGTG CGCTTCCTTC GCGTGGCGAC CX3CGATGTGC GACGTGGCCG AAACAGAGGT GGTGGCGGTG GCGAGCCX3TG AGCCX3AACGG TTCX3CAGCGC GATTCX3AATG CGAGGCGGTG CTGGGTTACC
GAGGA.TCGTG CCTTGGA.TGA.
GCGGATCGCT
GATGCCAGCA
ACTCX3GAGCA
TTCTACCX3GA CCAGA.CTTCT GTCAACATGG CCCGAACTAG GGCA.TCGATT
ACCGAGATCG ACCAATCX3TG ATCGCACTGT GAGGCTGGGT TACCAAAGCA CCCGAAACCG CAGAACAGGT TTCCGGTGGA ATCCAGGCGC GCTCGATGCX3 GGATGCTGCC ATCCGGCGAA AGCGGCTCCT 8640 8700 8760 8820 8880 8940 9000 9060 9120 9180 9240 9300 9360 9420 9480 9540 9600 9660 9720 9780 9840 9900 9960 10020 10080 10140 10200 10260 10320 10380 10440 10500 10560 10620 ---------7---舞------1T------A·(請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（）
GGAGCGGCCG GATCGGCAAG GGCGTCCGA.C GAATTACCTG GGAGATCGGT GGACATCCGC CGCCCGTGCC
CACCGITGCC
CGTGATCCGA
CCCTGCGGTG GATCGGTCAG CX3CCTCGAAG GCCATCCGCT GTCGAACCAC GGAGAGCGGA GCCGAATGCG CGGGCCACCG
GACATCGATG
ACCGCTCGCC TTCCTCCACC
TATCGCACCG GCTCGGCACT GAGTCGGGCG CACCTCGGAT GGGCGAATCG ATCGAGCGGA GCGGTCACCG GCCGGAGATT GCCCGTCGGT CCTGACCX3GG CACCTGGCAT GAGACGACCA TGCCACCX3CA AACGGAACGA
CCGTCTACX3T CAGACAAACA TGGTCX3GGCT ACGGCCGGCA AGTTCACCGC AACTCGGTGG TTCTCCTCGG TCGACTTGTC ACX3GTTTCGT
GCCGTTGCCG COTGCTTGCG GGCCAGGA.GG CGACGTGGTC
CTCCGGTGCA CTCGTCGAAT CCCX3GTGAAC TGCGGCCGCA GGCCX3ACGCT GCCGGAGCCC CCTGCCGACG CACGGCCCAC TCX3AAGCAGG GATGATGGGG GGCGTTCGGC GACGGGTTCG GACACCCGGC
CCITCGCACX3 CGGGCGAATC GCGGGTCCAC CATCCGGAAG CTCX3CGGACC CTCGCGAGCT CTGGCGTACC TCTCGTCGTC
TCCGCTCACG GGGCAGCGTG GCACCACTAC GGCGTTCACG CGACGAGTTG CGACATCAGA GATCATCCAG ATAGCCX3CCC CCAGCGGGGA GCTGATCGCG GGCCAGGGCG
GGCCAGTCGT
TTCCTACCTG
CCGAGCTCGC GCACTTGATC GGCAGATCGG GGTAGGCAGC ACCCCGTCAT TTCGGTGGAT GCGCGGATTC GCAGTTCAGG TGCCCACCCT GCGCATAGCC GGTAGCCGTT
GGGCCACGGC TACGACGGGG CAACTTGGCT CGATCTTCGC ATGCCAAGGG CCCGTGCCGC GGTAGCGGCG
AACGGCX3GTA GGCATGCCCG GATGTCCAGC TGCGTAGGTG CCAGATGCCG GGCGGCATCG AGTACCX3AGG GATCAGCTCG ACCGAGGCCG GATGTTCGGC CCX3GTAGAGG GACGGGCCGG ：AGAAQ -61
CCTGGCATGC ATGCAGAGTG GAGAAACCGC TGACGACGAC AAGAACCTGC TGCTGCX3GGA CX3CGACCTGC TGCAATCCX3G ATTCCGCCGC TTCCCX3ACAC CTGGACATCXS GTGTCTATCC GTTCTCGGCG CTGCTCCAAT CGCAGCGCGT ACGAGCTCTG CCGCCCGCCG AGTGGCAGGC TCCTTGCCAG CGGAAGATCA GCAGGGACAG G03TGGACGA
GGCATCCGCG
GACX3GCTCGG
TAGCTGTCCC TAGACGAGCG GCGCGCCATC CCGAGGAAGC CGACCCGCTT ACCAGGCCGG AGATCGATCG GGGTGCAGTT ACCX3GGCAGT AGCATGGCGT CCTTCGTAGT
GGTAGTAGTT GAGGCTCACC AGAAGTGCTC GAGCCAATCC GGAGTCGCTC TGGGGACCAC GAGGTTGCTC GGGTGACGAG CGGTGAGAAG CCAGCACCGG GCACCGCACC CGCCGGCX3AA CGGTCGTCAG GTCCCTGCGC CX3GTGATGAC CGGTTCCGGT
ACCAGAACGG TGCCGGAGAC ATTTGCCAGG CCTTGGCTGC GCCCTGAGGA GCGTGCCCGG TCATCCGCX3G GTGCCCGCA.G 10680 10740 10800 10860 10920 10980 11040 11100 11160 11220 11280 11340 11400 11460 11520 11580 11640 11700 11760 11820 11880 11940 12000 12060 12120 12180 12240 12300 12360 12420 12480 12540 12600 12660 I---:-II---舞------1T------0Φ(請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
ATCGTCGCCG AGGAGCATGA GCAACCX3CGG TAGCGTTGCT CX3GAGCAACT
ACCAGGCTGG AACCCATGCT CGATCAGCTG GGTAGGTGCC CGTCGACGTA TCTCGAACCC CCX3TCCAAAC CGAACCGGCC
TTCCTCGTTT TGCTGGTCCC GACAGCCGCA CCAGGAGACC GGCTTCGCTG CGCCGCGTAC
GGCCATCAGG CTGGCGTAAT GGTCCGTGCT GGCTCGACX3C ATGCACCTGG ACCAGCGCCX3 TCTTCCX3GGA AGGATTCGGT
CCGGATGTTT TCGCCGCGAT
TCTGTGCCX3T TGAAGCTGTT GTCGAACCCG GGACCTCGCG
CCGGTATTCC GTCTCCCAAG ATO3AGTTTC
CAAGGTATGG AGTGATGATG GATCGCGGCG
CGATCTGCAC GACGGACTGC ATCGCCCATG CX3GCCTGAAA GCCTGGTCCA GGGTAGGGCA
CGAACGCCGC TGG03CATGC AACAGGTGCG CTCCGGGACG GCAGCA.TCCG ACCACX3GTGT GACGCCCGTG
CCAGGTGCAA TGACGCCTIT CCAGGTAGCT ACAGGTTCTT CGAATCCGGG ACCGGGGGAA CGATGATGAT TCTGGTCX3GC CCATCCCGAA CGCCACCGTC GGAACTCGCC CCGTGCGGTA CCACTGCX3GA ATGTGGTGGT CGAACAACTC CCGGTCGTTG TCTCGCCTCG CCGCGCGGAA
TATGTCGTCC CTCCAGGAAC CX3GCTCGTAC GAGCAGGCTG AGCATAGGTC CAGCGTTTCC GTCGAACGGT GCGGACGGTG CACGAGGCCG GAAGTTGTAG GAGGTGTCGC GTGGGAGGCG GATGGCCTGG TCX3GAGGAAG GGCX3ATGAGA CTCGGCCTTG GTGGGTGATC GAGGATCTCG
CGCACX3GACT A03GGCTGCC GAGCGCGGCC TTGTCGATGA GGCACCX3GCA TCCTCCCGAT CGCCAACGCA TCGAAGATGG CCCTCTGCTG TTCACTCGTC AGACTCCTTG GCACCCAAGC GCGATGTTGT GGTAGGTGTG GAGCCCX3CAT ACCGTGGTGC GTCCACAGAT CCTCGATCAC AGGGATGTGC GCACGTGTCC CCX3TACTTGT CGTCAACX3GC CAGAGCCTCT GCTGGTCGAG CX3GTGGAAGT AGCGCTTCCA CCACCX3ACAC CGATCTCCAG TCJGTATAGCG GGGTGAACCA AGCAAGTTGA GGTCGGGACG AAGCCATCGG ACAG1TCCX3A 1TGGTGCTCC GGGCGCCGAC TOSGTGAGCT CCTAACCGAT ATCAGCTCAC CX3GACTGTAG TGGACCGCGA CCTCGGTCCG TCGATCAGCA CGGGTGCGAT
TCACGGTGAT CAITGCCGCA ACAGGTCGGT ACCCGCCCGC ACTCCACCTG CTCCX3CGCTG AGGAACGCCX3 GAGGCCGACC
CGGGCACTGC GTATACX3CCA GTTGATGTGG GGCCAGCTCC GAAGGACTTG CATCTTCAGG GA.TGCGCACC GTGCAGGCCG TCGGTGCCCG CGGACCGGGT GGCCCTGGGA CCGCAGCGGG CGTCAGGACG TTCGATGTCG CCTGGCGAGT 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）
TCCX3GTGACT
CCAGTAACCG ATCCGCGGTC TTCACGTCGG CCTTCGGCGT AAATTGCGTT ACGCCTTCCA GCCTGCCCX3C CCX3CTGCGCA CTGCCATCGT TCGGGCTTGC TCGAAAACGT GATTCGCCX3C GGGCGATCAC CCCCACTTGT CAGCCGGCGA ATCGAACCX3G GCTCCTGGGC ACGTCTCCGA
12720 12780 12840 12900 12960 13020 13080 13140 13200 13260 13320 13380 13440 13500 13560 13620 13680 13740 13800 13860 13920 13980 14040 14100 14160 14220 14280 14340 14400 14460 14520 14580 14640 14700 I---^-II---^#1-------—訂------線 Φ-(請先閲讀背面之注意事項再填寫本頁) 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） GGCCAGGCTC GCCGCACTGG ATCCGGCGGC GAGGA.TGATG ITTaSATCTC GTGCGTTGTG GACATCOTGA TGAGCTCCTC ATGGCTGACC CGTGCCX3GCG GTTTGATCGA CAGGCCGTGC TGGAAGATGT TCTGCGGATC TTGGCCCGCT GCA.GCCX3CX3G GTAG1TGTCT TTGTAGTACA GGTCGTGCCA GAGGTGTTCC AC^TGGATC GGCCAAGTCG GTGTCCX3GGT AGTTGATGTA ACACX3GGTAC CTGGCACCGG AACTCCX3CCX3 GTTKX3GCGT ACATCTCGCG CGAATCCAGG TCAGATGCCG CTCGTCCTCG GCGGGCTCCG ACCAGTTCGT GCTTTGAGAA CCGAGTCGCG CTGAGCGAGT GCGGTGGCCG ACGGAGCCAC ATACCGCCX3T AACCX3AGCAG C^ACAGCXSCC GCCX3CAGGGT TGTCGTATCC AGCCGCCGGT AAACCX5TGGC T^TTGAGCT TCGGACAGCC TTGACCTTGG TCCX3TTGCAT GCCXGGTTCG CCX3CCTTCGG CGATCX3CCCC GTCGATCGCA ACCACGGCAG GGTTTCCCGC AGCCCTTCGG CTGGAGTCAC GCG1TGATCX3 CCGACAGGTG TTCGGCCA.GG GTGCX5TTCCX3 CGTTCGGATC AGGTGAACX3T TCAGCGTGAC GTAGCCAGCT TGCCGGTGTG CGCAGACX3AG AACCCX3AGTT GCGTGGATTC AGGCX3CGCTG TGCTOCTCGT ACCAATTGCC AGGAGCACGG 03AA.TGACTG CTCTGTCAGT TCGTGCCACG AGCACTGTCX3 03GGCGGCCX5 TGGCAGGAGC TCTGCGGCGT GTTCGGAGCC AAAACCTGGT GACGATCCCX3 AAGTTGCCGC CACCGCCACC CACCACAAGT CX3TGACCX3GC GCCCGTGGAG TTCCGGTCGG CCTCGACX3AT CCGGCCTGGT CGACCACGAC GACCTCGACG CCTTGAAGGT AGTCGACGAC CGGCGCGACA GCGGGCCGTA TCCCCCGCCG AGGATGTGCC CGCCTGCGCC CATGCGCCX3G TCGGGATCGT CACX3CCCCAG TTCTTGAACA GGGTTCGGTA AGGGCGGCGC CCGCCTCGAT CGCGAATGCC CCGCGCGTGC TGTCGTAGTA AGCTCX3GAGA GGTCGACX3AG CACTCGGATC GCCGGGTCCG CAACGAGATT TGCCCX3CCX3C TGCGGACCCC TACCCX3CCTG CCGGTGCGCA CGGCGTCGGC ACGACGTCTT CGGCGGAGCT GGCGMOTGG ATGCGTTCGG GTTTTCCGGT TTGTGCCCGA CGACGAGGTC CX3GATAACGA GGATCX3TCGG GCTCGACGGT CCTGGGGTTC GACGATTCAT GGGTGCCGGG TCATGGAATT CX3GGCACCX3C CTGACTGGTC CACTTTGTTC GCCCGCAGCC GAGATCATCT ACGCGTCCGG GTGTGTTTCA GCTCATACGT GAAACCC!GGT CGCCTCCX3CC GGCTCTACTT TATCX5CGGTG CX3CATGGTGC CX3TATGCGCT GGAACCX3AAA AGGTGATGAC TGAGATCGCA G1TGCCCCCT GGTCGGTGGT GGAGCGTTTG CTGCTCX3CX3G CCCGGCGAAG CTCCAGGAAG CAGTGCAGGT GGCCGGACTG GACGCGGTGG CGTCGACGAA CTCGTCGTAC GCTGCGATCC GCTGTCGTTG GACGAGTCGG -63 -
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）
CGTTCCACGG GGGTGAAAGC CCACCGCGCT GGCAACACCG GGAGCCGTCX3 GTAGAAACCG GACGAACAGC GGCATTCGCC GTAGACX3GTC GTAGGCX3GCT GGCCACCTGG GCCX3ACCTGG
CGATCGGAGC CACGTCCGGC GGTGTGCGCC GTGCA.CTTCA CGAACCGAAT CACCCCGGGA CACCTGCCCG CACGCGGTTG
GACGGCGTGC GAAACX3GGGG GATCTCTGTT CCCTCCTTTT GTGATTATCT TGTGGATCGA TTACCATGAG
CCGACGCCAT TGCGAATCGG 14760 14820 14880 14940 15000 15060 15120 15180 15240 15300 15360 15420 15480 15540 15600 15660 15720 15780 15840 15900 15960 16020 16080 16140 16200 16260 16320 16380 16440 16500 16560 16620 16680 16740 I---^---：---------——----- (請先閱讀背面之注意事項再填寫本頁) 1237058 at B7 五、發明説明（ 經濟部智慧財產局員工消費合作社印製
CCTGGAGATC ACITCTGGCG CTCAGCTGGT CCX3GAGAACC GTTGAGCTCX3 ATCACGCAGG CCTGCGGCTC GCGGCGGTCG CCX3AAGCAGC TGCTGTTCTC CGGTTCGACG CGGTGGATCT GCTGGAAGGG CTCTTCGGCC CGGTTGACX3G CMGCGGCAC AACAGCCGTG AAGTCCGCTO GTCX3GACAGC ATGACGCAGT TCTCGCCCGA CCAGGGCCTC GCCGGCGCGC AGCGCCTGCT GGCGTTCCGG AACAGGGTGT CCACCGCX3GT GCACX3CCGTG CTGGCCX3CAG CCX3CCACCAG GCGCGCGGAC CTCGGTGCGC TGGCAGTCCX5 CTACX3GATCC GACAAATGGG CX^CCTGCA CTGGTACACC GAACACTACG AGCACCACTT CTCCCGATTC CAGGATGCCC CGGTGCGAGT GTTGGAAATA GGAATCGGTG GTTATCACGC ACCCX3AACTC GGTGGTGCTT CX3CTGCX3CAT GTGGCAGCX3G TACTTCCGGC GAGGTCTCX3T TTACGGGCTG GAC^TTTTCG AGAAAGCCX3G GAACGAAGGG CACCX3AGTGC GAAAGCTGCG AGGTGACCAG AGCGATGCX3G AATTCCTGGA AGACATGGTG GCGAAGA.TCX3 GCCraTTCGA CATTGTCATC GACX3ACGGCA GCCATGTCAA CX3A.CCACGTC AAGAAATCCT TCCAATCCCT GTTTCCXSCAC GTCCGCCCAG GTGGTTTGTA CGTCATCGAG QATCTCCAGA CX3GCGTACTG GCCCGGCTAC GGCC3GTCX303 ATGGGGAACC CGCGGCCCAG CGCACCTCGA TCGACATGCT CAAAGAACTG ATCGACGGCC TGCATTATCA GGAGCGCGAA TCGCGGTGCG GGACCX3AGCC CTCCTACACG GAACGGAACX5 TGGCGGCCCT GCACTTCTAC CACAACCTGG TATTCGTGGA GAAAC3GGCTC AACX3CTGAGA CTGCCGCGCC GGGGTTCGTG CCCCGGCAAG CGCTCGGCGT CGAGGGCGGC TGAGCCGTTC ACCAGCTGCG GCGCCAGTAG GCGCCCGTGC CGTCGATGTC GTGGATGGGT TCCGTGA.TCC CX3AGTTC03C GCGGAACCCC TTCACCX3CGT CCIOGCAGGA CGGCAGAAAA TAGTCX3TCGA TGATGACGAA TCCGCCCGGC GAGAGCTTCX3 GGTACAGGTT CCX3CAATGAG TCCA.TTGTGG ATIO3TAGAG GTCX3CCX3TCG AGTCGTAGCA CGGCX3AGTTC CTGGATGGGG GAACCAGCCG GGGAGGAACC TGACCTGTTC CCGGACGGTC TCAAGCGATA CGCCAAGCAC GTCGTTGTAC TCGTGCAGCG CCATAGCCTG GTCCGCTTGG TGGTCITGCG O^GCITTC CGGCATTCCC TGGAAGGAAT CCACTACCCA. GACGGTACGT CCGGTATCTC CGAATGCCTG GAGAACCGCG CGCATGAAGA TGCATGCGCC GCCCCX3CCAG ACACCGGTCT CGG03AAATC CCCGGGAACA CCCTCTGCGA GCACGGCTTC CACGCAGTGC TGGAGGTTGT CCAGCCGCTC CAGACCGATC ATCGTGTGCG CGACAGTTGG
CCAGTCCX5TG CCTTTGGCCC OXSATGCGGC CGATCACTGT AAATCGTGTT GGTGAGTACC GGATCCAGCT ATGGCCGCAG TGTTCTCCAG TX3TCCX3CACC
GGCCGTGATC CGTTGCGATT GATGCCCGCC
GTTTGATTGC
ACTGTTCGTG
GCCAGGCGTT GGTCCAGGTA GACTAGTTCA GA.TGGGGCA.T AAGCCGGTGT CGCCGAGCAC GCCIGCrCAT CCX3GCAAGCA AACTGGTCGA AGTACTGGGG
16800 16860 16920 16980 17040 17100 17160 17220 17280 17340 17400 17460 17520 17580 17640 17700 17760 17820 17880 17940 18000 18060 18120 18180 18240 18300 18360 18420 18480 18540 18600 18660 18720 18780 I---：---Γ---舞----—1T------A，(請先閎讀背面之注意事項再填寫本頁) 本紙張又度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 1237058 atB7 經濟部智慧財產局員工消費合作社印製 五、發明説明（）
AAGCACGA.GT TGCGGGATGC CX3AGTCGGGT CGCX3GTGAAT GCCX3TTCCCX3 AGCCX3CCCGC GCAGATGACC AGCTCGCAGG TACGCAGGAA CAGGTTGAGC GGGACCGAIT CGGCGATCCG GGCGTTGTCG GGTAGGTCGG TGAGAAGTGC CCX3GTGCTCX3 C3GGGGAACGG CGATCACGGC CTCXSACGCCG GGCAACTCX3G TGGCAGCCX3C TACTGCGCGC AGCAGCGGAG CCX3GCCCGGT GGCX3TTCAGC ACCATGCGGC CCATGCAGAT GCAGACCCGC 03TGCTGAGG TGCGCGCCX3C GCCCCATGCC GGGAATGCGC OSCTTCCGTr GTACGGCACG TACTGGACCG GTGCGCCITG CGGCGCGTCG CTTGCTTGCA GGCTCGGCGG ACAGGGATCG AGGATGAGCT CGGGAGTGGG CAGGCCGGTC AGTCCX3TGGT GCCX3GCACAC CGGGTCAAGC AACTCX3TGGG CTCGATCX3CT GAAGGGGCCT GCX3GTGGGGT CX3ACTCCCCA GCGGTGCAGC ACGACCX3GCA GGTCGAGCAA TCCGCCGAGC ACCCGGCCGA TCAGCGCGCA GACGTCGACC AACAGCACrG ACGGTCGCCA GGCCTCGGCC AGTCGAAGGT ATTCGGGGAG CTGATCGAGC GAGCTTTGCX5 CGACATTGGA OSCGGTCTGC TCCCACAGTT GCCGGCCTGC CTCGGTGTCG 03CTGACCX3A ACGCCX3GATT GGGAAAGCGC AGCTGCGTGG TTCCACCCGT ATCGCCX3GTC CTGTCGTTCC CX3CGGATCCC GGCCGTGGTG AGACCTGCAC CATGCGCGGT CGCCTGCAGC TCTGGTGGTG CGGCGATCAG GACCTCX3TGC CCGGATGCTT GCAGCGCCCA GCACAGCGGC ACCATTGCCA TGAGATGCGT CX3GATAGGGC AAGGGAAC!GA CGAGTACX3CG CATACTTCGG ACCCCAGTCT CTITCCCCCG ATTAGCGCAG CAGCCCCTAC TCCCATTGGC CAGGATTTGG AAAATGCX3CT GCGTATGTCG
CX3CAACAATA GTCTGTCACG GCAGGAATGT GCACCTGGTT TCACX3CGAAC GAGTGAAATG ACCTGTACGG TGATCACCCT TITGCCTCCT GGCCGGATAG ACCGCGAATT AACTGACGGC TAGTTTGCCG
ATCGCCX3TTG ACGTCCAACX3 CACGCGACCA TCGAAGATCT CGCGAGCTCC GCTCGATCGG GGGATTCATG GGGAAGATTT TACCGCCX3CA
CTGTGTGTTT CCK3CTCGGT TCCAGAAAAT TACGAGAAGG TGAACX3TTGC AGAGATCAGG CATACCX3GTG TTGCCAGGTG GCX3CACCAAC ATCX3CAGCAG GTTGGGCAGA TGTATGACCT GGTCACX3CCG TTGCTGAACT CX3GTCGCX3GG CX3GCCCCTGC GCCATCCACC ACX3GCTACTG GGAGAACGAC GGGCX3GGCTT CCIOGCAGCA GGCCGCCX3AC 03GCTCACCX3 ACCTTGTCX3C CGAACX3GACC GTGCTCX3ATG GG3GCGTTCG ACIGCTCGAT GTGGGGTGCG GTACCX3GA.CA GCGACAACGC GATCCAGATC ACCGGCATCA CCGTCAGCCA GCCATCGCCG CI^TTGCGC ACX3CGAACGC GGACTAAGCC ACCGGGTGGA GTCGATGCCA TGTCCCTGCC GTACCCGGAC AATGCITTCG ACX3CCGCCTG GGCCATGCAG TCGCTGTTGG AGATGTCCGA ACCGGA.CCX3T GCCATCCGGG AAATCCTTCX3
AGTACTCAAA CGGGATGCCG ACITCTGGAA
CACCGAGGTC GACCGGCCTT CGGATCTGCC CGAGATCCTC GATTGC3GAGG ACGTGTCGTC 18840 18900 18960 19020 19080 19140 19200 19260 19320 19380 19440 19500 19560 19620 19680 19740 19800 19860 19920 19980 20040 20100 20160 20220 20280 20340 20400 20460 20520 20580 20640 20700 20760 20820 I—I: ： 罈丨(請先閱讀背面之注意事項再填寫本頁)
、1T 線 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 1237058 atB7 經濟部智慧財產局員工消費合作社印製 五、發明説明（ GAGGACCCGG TACTTCATGC CX3CAGTTCX3C CGAAGAGCTC GCTCCX3CACC CGCGGACAGG TACGGGCCGG CTGTCGCCGG CTGGGCCGCC GCGGTCTGCG ATATGCCCAC GACATGGGCT ATGCGATTCT QACGGCGCGG AAGCCGGTCG CGCCGCAATT CGATGACGTT CATGCGCCGT CTCGGAGAAT CGCCGGTGGC GAGGCTGAAC TTACTGGTGG TGTGTCCAGG AATCGGA.GGG GCAGTACCX3A CCX3GGAACCT GATAGCCX3TC ATCGGACTGT CCTGCCX3CCT ACCCCAGGCG CX3CACCX3GAA CGGACGCCAT CACCACGGTC CCCX3TTGCCT GGTCGGGATG CGCCCAAGGG CCCGGAATGG TGGCTGATGT CGACK3CTTC GATCCCX3AGT TCTTCGGGAT CTCGCCGCGA CCGTGGATCC CCAGCAGAGG CTGGCTCTGG AGCTCGCCTG GGAGGCACTC GTATCCCCGC CX3GCGAGCTG CX3CX3GTACTG CCX3CCX3GTGT GTTCATGGGG ACGACTACGC CGCCCTGCTG CGCGAGAGCC CGCCGGAAGT CCC3GCACCCA TCX3AAGCCTG ATCX3CCAACC GCX3TGTCCTA C^AGCCTGAC GGTGGATTCA GGTCA.GTCCT CX3TCCCTGGT CX3GCX3TGCAT AGAGCCTGCG ACGGGGTGAG TGCACGATCX3 CACTCX3CCGG CX3GCGTGAAC CCGCCGAGAG CAACAGCGCT CTGATGGACT TCGGCGCGCT CTCCCCGGAC TCACCTTCX3A TGTGCX3GGCG AACX3GTTACG TCCX5TGGTGA CGATCAGGCG CACGCCGATG GCGACCGGAT CTACTGCCTC CAACGATGGG GGCGGTGCCX3 GGCTCACCGT GCGCCAGGCA TACCX3GAACX3
AGCACGGGAT ATTATGAGAA
GGCGCCAGCA ATGAGCGAAG CCTGACCCX3G CCGGAAGGGC GGTGGTTTCC GAAGCGGCAA GAAGACX3CCG GCGATCTCTG
TACCGCCTCA
CTCGCCAGCG CTCAACCTGG
ATCCXSCGGCA
TCGAGCTCCA CGGCAGCGCG CIOTCCTGGG ACGTCGGCCA TCTGGCACCX3 CGAACTGCCG TGGACGAATT GAACCTACGC
GGGATCCCGT
TCACCGGGTT
GACGCCCAGG GTGCAGTATG
GAAATCCCGC ATTTCACCGC CCCCAACCCX5 ATCTGCGGCC TGGGAGGCAC GAACTGCCAC CCGGCACGTC CCGGGTGGAG CGACGGCGCA GTGGACCCGC TCTTGTCGGC CAGAACACCG GTCGCATTGC TCAATACGGC CGGTCAAAGT CCGTTGGACG TCGCCTACTC ACTGGCGACC CGCTACCGCA CCGGGCCGCG CTGGTCGCGG ACGACGAACC GAAACTGCTC AGGCCCTCGC TGACX3GCX3A.C GA.CX3CGCCCA CX3CTGTGCCA 03GCGCGA.CT CCCX3GACAGG GCAGCCAGTG GATCX3GGATG CGATGTCGGA OTGCGCCIGAC CTGGATGTGC TGCGCAACGC GGCCGGCGCT -66 -
TGCTCGAAAC CACACCTGGA
ATGCCGTGGG CACACGCACC ACTCGATCCG
GCATTGGCGC GCGCACCITG 20880 20940 21000 21060 21120 21180 21240 21300 21360 21420 21480 21540 21600 21660 21720 21780 21840 21900 21960 22020 22080 22140 22200 22260 22320 22380 22440 22500 22560 22620 22680 22740 22800 22860 ----^---：---舞---------1T------^，(請先聞讀背面之注意事項再填寫本育) 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 atB7 經濟部智慧財產局員工消費合作社印製 五、發明説明（）
ACCACGACGh TGTCGTCCAG CCCGCGCTGT TCGCCATCAT GGCGTTCGTG GGGCGTGCGT CCGGTGGCGG CGGCCTGCGT CGCCGGGGCC CTGTCCGTCC GCGATGCCGC GCAGGCTTCT GACGGCGCTG GCCGGCAGTG GCGCX3ATGGC AAGAGGTGCG GCAAATCCTG TTGCCCTGGC GCGATCGGAT GACCX3TCX3TC GACCCTGGTG TCAGGGGACC GGGAGGCGAT GCX3CA.GACCG AGAGCTCCX3G ATGCGCCGGA ACATCX3AGGT TGTCCGGGAT GAAGCATCCC GATCTATTCG ACGACGACCG GGGACCTGCT ACTACTGGTA CCGCAACCTT CGTCAACCGG TGAAGCGGGG GTACGACX3CA TTCATCGAGA TCCAGGAAAC CGCCGTGCGA GCAGGGCGGG CATGCGGCAG GCGCTGACX3T GCACGCGGTC TTCGCCX3GTA ACGCCnTCA GCGACAGCGC TACTGGCTGG ACGCGAAGCT AGAGCX3ACGT GTCGACGGCG ACTCGACGAC CCTCACGATG ATCCX3GGCAC CGAAAGAGGT GGACCCGGAT CGGACGTTCA AGGACCTGGG TCGAGCTGTG CGACCGCCTA AACGCCGCCA TCX3ACTGTCC TACGCCX3GAC AAGCTCX3CCC GCCAGGTACG CGGCTCCCAT GACGTCACAC CGGCCGGACT CCGATGCGGA GGATGGGCTG TCGGTTTCCG GGTGGGGTGT CCTCGCCCGA CCX3CTGGGCG GGACGTCGTG TCOSAGTrCC CGGCTGACCX3 CGGGGACATC GCACGTGCGC GCCGGCGGGT TCTTGCATGG GGTTCTTCCX3 GATITCGCCG OSCGAGGCGT TGGCGATGGA TGGAAATCGC CTGGQAAGCA GTCX3AACX3AG GCX3GGA.TCAA GTCAAACCGG GGTCTTCX3TC GGCGCGACCT CCCTGGACTA CGTCCGAGGA GGCGGCCGGG TACGTGCTCA CCGGCAGCAC GGGTTGCGTA TTCX3TTCGGG TTCGAGGGCC CTGCGGTGAC GGCCCTGCAT TTGGCX3TGTC AGTCGTTGCG TGGTGTGACC GTGATGGCCA CX3CCX3GGGAT GGCGCCGGAT GCTGGTCCGA GGGTGCTGGC CTGGTTCTAC GGCATGAGGT
GGTCTCX3CTC
GAGATCGCGG
GGCGGAACTG ATACGCCTCC GCCGGTCGAA GGACCGGCCG
GCKX3GGACA
AGCACACX3TA
CATCCCGCCG GGGGTGAACG CTGGCCX3AGT CAITCGCCTC CCCAGGACGG ATGGACGCCG GAGGCCCTGT ACTGCX3AACA
TCCCX3ZVCGTC TTCGCCGAGG GGTCCTCGGC CTTCGATTCC ACTCX3CACCG GACGTTGTTG CX3AGCCTATC GGAGTTGTGG AGGTTGGGAC CGCCCCGGAT TCCACAGCAG CCCGCAGCAC CGGGCCACGC CACX3AGTGTG GGTGGATACG TTCGGGTGAG GTTCGTGGAG GGAGGCCX3CC GTCGGATGCC TCAGGA.CX3GT
CACX3GAGTGG CTGCCGACGT GCCATGCCCG GCGGACGTGG CACTCCGATC TO3A.TGGTGG
GCCGTGATCX3 CAGTTGGTCG CTGGAGCGTG TTTGACCCCG CGGTTGCTGC CTGCACGGAA
TGTGATCTGG TTTTCGCGGC GACGGCACCG 03GCGGAATG GCGTCGAATC 22920 22980 23040 23100 23160 23220 23280 23340 23400 23460 23520 23580 23640 23700 23760 23820 23880 23940 24000 24060 24120 24180 24240 24300 24360 24420 24480 24540 24600 24660 24720 24780 24840 24900 IIII 丨·"： 嶙—(請先閲讀背面之注意事項再填寫本頁) 訂 線 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 經濟部智慧財產局員工消費合作社印製 1237058 a7 B7 五、發明説明（） GTTTGACCX3C GCCGAATGGT TCGTCX3CAGC AGCGGGTGAT TGCCCAGGCA TTGGCGAGTG 24960 CGGGGTTGTC GGTGTCCX3A.T GTGGATGCTG TGGAGGCX3CA TGGGACGGGC ACGCGGCTTG 25020 GTGATCCGAT CGAGGCGCAG GCGCTGATCG CCACCTACGG CCAGGGCCGG CITCCGGAAC 25080 GGCCATTGTG GTTGGGCTCG ATGAAGTCGA. AC^TCGGTCA CGOSCAGGCA GCTGCX3GGGA 25140 TAGCCGGCGT CATGAAGATG GTGATGGCGA TGCGGCACGG GCAGCTACCG CGCACGTTGC 25200 ACX3TGGATGA GCCX3ACTTCT GGGGTGGATT GGTCGGCX3GG GACX3GTTCAA CTCCTTACGG 25260 AGAACACXSCC CTGGCCCGGG AGTGGTCGTG TTCGTCGGGT GGGGGTGTCG TCGTTCGGGA 25320 TCA.GTGGTAC TAACX3CGCAC GTCATCCTCG AACAGCCCCC GGGA.GTGCCG MTCAGTCTG 25380 CC3GGGCCX3GG TTCX3GGCTCT GTCX3TGGATG TTCCGGTGGT GCCGTGGATG GTGTCGGGCA 25440 AAACACCCGA AGCX3CTATCC GCGCAGGCAA CGGCGTTGAT GACCTATCTG GA.CGAGCX3AC 25500 CTGATGTCTC CTCX3CTGGAT GTTGGGTACT CGCTGGCGTT GACACGGTCX3 GOSCCOGATG 25560 AGCX3AGCGGT GGTGCTGGGG TCGGACCX3TG AAACX3TTGTT GTGCX3GTGTG AAAGCGCTGT 25620 CTGCCGGTCA TG^GGCTTCT GGGTTGGTGA CCGGATCTGT GGGGGCTGGG GGCCX3CATCG 25680 GGTTTGTGTT TTCCGGTCAG GGTGGTCAGT GGCIOGGGAT GGGCCX3GGGG CTITACCX3GG 25740 CT1TTCCGGT GTTCX3CTGCT GCCITTGACG i^SCITGTGC CX3A.GCTGGAT GCIGCATCTGG 25800 GCCA.GGAAAT CX3GGGTTCX3G GAGGTGGTGT CCGGTTCGGA TGCX3CAGTTG CI03ATCGGA 25860 CGTTGTGGGC GCAGTCGGGT TTGTTCGCX3T TGCAGGTGGG CTIOCTGAAG ΤΙΌ0ΙΟ3ΑΓΓ 25920 CGTGGGGGGT TCGGCCGAGT GTGGTGTTGG GGCATTCGGT GGGCGAGTTG GCGGCGGCGT 25980 TCX3CGGCGGG TGTGGTGTCG TTGTCGGGTG CGGCTCGGTT GGTGGCGGGT CGTGCCCX3GT 26040 TGATGCAGGC GTTGCCGTCT GGCX3GTGGGA TGCTGGCGGT GCCTGCTGGT GAGGAGCTGT 26100 TGTGGTCGTT GTTGGCCGAT CAGGGTGATC GTGTGGGGAT CGCCGCGGTC AACGCTGCGG 26160 GGTCX3GTGGT GCTCTCTGGT GATCGGGATG TGCTCGATGA CCTTGCCJGGT CGGCTGGACG 26220 GGCAAGGGAT CCX3GTCGAGG TGGTTGCGGG TGTCGCATGC GTTTCMTCG TATCGGATGG 26280 ATCCX3ATGCT GGCGGAGTTC GCCGAATTGG CACGAACCGT GGATTACCX3G CX3TTGTGAAG 26340 TGCCGATCGT GTCGACCTTG ACCGGAGACC TCGATGACGC TGGCAGGATG AGCGGGCCCG 26400 ACTACTGGGT GCGTCAGGTG CGAGAGCCGG TCCGCITCGC CGACGGTGTC CAGGCGCTGG 26460 TCX3AGCACX3A TGTGGCCACC GTTGTCGAGC TCGGTCCGGA CX3GGGCGTTG TCGGCX3CTGA 26520 TCCAC3GAATG TGTCGCCX3CA TCG3ATCACX3 CCX3GGCGGCT GAG03CGGTC CCX3GCX3ATGC 26580 GCAGGAACCA GGACX3AGGCG CAGAAGGTGA TGACX3GCCCT GGCACACOTC CACX3TACX3TG 26640 GTGGTGCX3GT GGACTGGCX3G TCX3TTCTTCG CCX3GTACAAG GGCX3AAGCAA ATOSAGCTGC 26700 CCACCTACGC CTTCCAACGA CAGCGGTACT GGCTGAACGC GCTGCGTGAA TCTTCCGCCG 26760 GCGACATGGG CAGGCGTGTC GAAGCGAAGT TCTGGGGCGC CGTCGAGCAC GAAGATGTGG 26820 AATCGCITGC ACX3CGTATTG GGCATTGTGG ACX3ACX3GCGC TGCTGTGGA.T TCCCTCAGAA 26880 GCGCCCTTCC GGTGTTGGCC GGTTGGCAGC GAACCCX3CAC CACCX3AGTCC ATTATGGATC 26940 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） -----^--^---^0------1T------ (請先閱讀背面之注意事項再填寫本頁) 1237058 μ B7 五、發明説明（） AGCGGTGTTA CCGAATTGGC TGGCGGCAGG TAGCCGGACT CCCGCCGATC GGAACTCTTT 27000 TXX3GTACCTG GCTGGTCTTC GCGCCTCATG GCTGGTCCAG CGAACCGGAG GTGGTGGACT 27060 GCGTTACGGC ACIOCGGGCA CGTGGTGCCT CGGTGGTGTT GGTCGAAGCT GATCCCGACC 27120 CGACCTCCTT CGGCGACCX3G GTACX3AACCC TGTGTTCGGG CCTTCCGGAT CTTGTTGGCG 27180 TGTTGTCAAT GTTGTGCTTG GAAGAATCGG TCCTTCCX3GG ATTTTCTGCG GTGTCACGGG 27240 GTTTTGCX3TT GACCGTGGAG TTGGTGCX3GG TTTTGCGGGC AGCTGGTGCG ACTGCCCGGT 27300 TGTGGTTGCT GACGTGTGGT GGCGTGTCGG TGGGAGATGT ACCGGTTCGT CCAGCGCAGG 27360 CCCTGGCGTG GGGGTTGGGG CGTGTIOTGG GGTTGGAGCA TCCGGACTGG TGGGGCX3GCT 27420 TGA.TCGATAT TCCX3GTCTTG TTCGACGAAG ACX3CTCAAGA GCGGTTGTCG ATTGTGCTGG 27480 CAGGTCTCm TGAGGACGAG GTCGCGATCC GTCCTGACGG CATGTTCGCG OTTCXSGTTGG 27540 TACGCCACAC TGTCTCAGCT GATGTGAAGA AGGCOTGGCG CCCCAGGGGA TCX3GTGCTGG 27600 TGACGGGCX3G CACGGGTGGT TTGGGGGCX3C ACGTTGCTCG CIOGCTGGCC GACGCCX3GAG 27660 CCGAACATGT GGCGATGGTG AGTCX3ACX3CX3 GCX3AGCAGGC ACCX3AGTGCT GAGAAGTTGC 27720 GGACGGAACT GGAGGATCTG GGTACCCGGG TGTCXSATCGT GTCATGCGAT GTGACCX3ATC 27780 GCGAGGCGCT CX3CCGAAGTG CTGAAAGCCC TTCCGGCTGA A^CCCBTTG ACCGCGGTAG 27840 TGCATGCGGC AGGCGTGATC GAGACTGGTG ATGCGGCGGC AA1X3AGCCTG GCTCATTTCG 27900 ATCACX5TGTT GTCCX3CAAA.G GTGGCCGGTG C03CX3AATCr GGATGCCTTG TTGGCCGATG 27960 TGGAATTGGA CGCGTTCGTC TTGTTCTCAT CGGTGTCAGG AGTTTGGGGC GCTGGGGGAC 28020 ACX3GGGCTTA CGCAGCGGCG AATGCCTATC TGGATGCGCT CGCX3GAACAG CGTCGGTCGC 28080 GAGGGCTGGT 03CGACTGCX5 GTGGCCTGGG GGCCX3TGGGC CGGCGAGGGC ATGGCCTCCG 28140 GAGAAACAGG AGACCAGCTG CGCCGATACG GCCTITCCCC AATGGCTCCX3 C^GCACGCCA 28200 TCGCCGGAAT CCGGCAGGCC GTGGAACAGG ACGAAATTTC CCTGGTAGTG GCCGATGTCG 28260 ATTGGGCACG TTTCAGCX3CG GGATTGCTGG OSGCTAGGCC GQ3GCCX3CTG CTGAACX3AAC 28320 TGGCCGAGGT CAAGGAACTC CTCX3TCGATG CCCAGCCCXSA GGCGGGAGTC CITGCCX3ACG 28380 CGTCGTTGGA ATGGCGGCAG CGATTGTCCG CGGCACCGAG GCCGACACAG GAACAGCTGA 28440 TCCTGGAGCT GGTACGCGGC GAAACCGCTC TGGTGCTGGG ACACCCCX3GG GCAGCGGCCG 28500 TTGCATCGGA ACGAGCCITC AAGGACAGCG GATTCGACTC GCAGGCCGCG GTCGAACTCC 28560 GCGTTCGGCT CAATCGAGCT ACCGGCCTCC AGTTGCCATC GACAATTATC TTCAGCCATC 28620 CCACGCCTGC GGAACTGGCT GOSGAGCTGC GGGCGAGGCT TCTTCCCGAG TCOSC^GGAG 28680 CAGGCATTCC CGAGGAGGAC GAGGCGCQAA TCMaGCGGC ACTGACGTCG ATCCCX3TTCC 28740 CGGCCTTGCG CGAGGCAGGC TTGGTGAGTC CGCTGCTCGC ACTTGCCGGA CACCCGGTCG 28800 ACTCCX3GTAT CTCCTCX3GAC GATGCGGCCG CGACCTCGAT CX3ATGCX3ATG GATGTAGCCG 28860 GCCTCGTCX3A AGCA.GCGCTG GGCGAACGCG AGTCCTGAGA CCX3CCGACCT GGGAGATGAC 28920 GGTGACCACC AGTTACGAAG AAGTTGTCGA GGCACTGCGA GCATCGCTCA AGGAGAACGA 28980 一 69 _ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
-、1T 線 經濟部智慧財產局員工消費合作社印製 1237058 - 經濟部智慧財產局員工消費合作社印製 五、發明説明（
ACX3CCTCCGG 03CGGCAGGG ATCGGTTCTC CX3CGGAGAAG GGCGATGAGT TGTCGTTATC CCX3GTCAGGT CTCCTCGCCG TGCCX3GCGGT GTGGACGCGA TCTCCX3AAGT TCCX3GGGGA.T CGTGTTCGTT CCX3GACTCCX3 ATCGTCCTGG CACGTCGTAT TCAGGGCGTG TCGGAGTTCG ACGCGGGTTT CTTCGGGATT GATGGATCCG CAGCAGCGGT TGCTGCTGGA AGTCGCGTGG GCTGGAGCAG CX3GTCGACAC GCGGTTCCCX3 CGTTGGCGTG GGACTACX3CG TCGTGGTTGC GGACX3CCX3CC GCCTGCGGTG TGCX3TATTCG GA.TACX3GCGT ACTGCGGGCC GGTGA.GTGCX3 ACCTTGCCCT GAAGGTGTTC CTGGAGTTCT CCCGCCAACX5 GGTGCGGATG GCACTGGATG GATGCCCGGC GGAATGGGCA GGTGAATCAG GACGGTGCGT CGAATGGTIT GACCGCGCCG GGTGATTACC CAGGCGTTGG CGAGTGCGGG GTTGTCGGTG GGCGCATGGG ACX3GGCACX3C GGCTTGGTGA TCOSATCGAG CTACX3GCCGT GATCGTGATC CTGGCCGGCC CGGTCATACG CAAGCGGCGG CGGGTGTGGC TGGTGTGATC GCACGGGCAG CTGCCACGCA CGTTGCACGT GGAATCGCCG GGCGGGGACX3 GTTCAACTCC TTACX3GAGAA CACX3CCCTGG TCGGGTGGGG GTGTCGTCGT TCX3GGATCAG TGGTACTAAC GCCCCCGGGA GTGCCX3AGTC AGTCTGCGGG GGTGGTGCCX3 TGGATGGTGT CGGGCAAAAC ACCCX3AAGCG GTTGATGACC TATCTGGACG AGCGACCTGA TGTCTCCTCG
GACGATCCCA TCGCGATCGT GA.GGA.CCTGT GGCAACTGGC CGCX3GATGGG ACCTGGATGG
TTCGTCGGCA GCAGGTCATG TTCGGGTTCG TTGCACCTGG GTCA.CGGTGA C03GA.TGGGC GCCX3GACTGT GCGGTTGTTC AATGGTTCGT TCCGATGTGG
CCAATGGCCA TGCTGACGGG AGGGTCCTGC
TGTCGACX3CC
GGCGTTGACA GTTGTTGTGC ATCTGTGGGG GGGGATGGGC
TGGATGAGCG
AAGATGGTGA TCGCCGGAGG CCCAGGAGTG GCGCACGTCA. GGTTCTGTCX5 CTATCCX3CGC CTGGATGITG
GTGGTAGTGC CGCAGCAGCG ATGCTGTGGA TGATCGCCAC AGTO3AACAT TGGCX3ATGCG TGGATTGGTC
TGGATGTTCC AGGCAACGGC GGTACTCGCT ACCGTGAAAC
CGGTCATGAG GCATCGGGTT TGTGTTTTCC ACCGGGCTTT
ITGACGAAGC TTGTGCCX3AG CKSGATGCAC ATCTGGGCCA GGAAATCGGG TTCGGA.TGCG CMTTGCTGG ATCGGACX3TT TGGATTCGTG CGGCGTTCGC GGCGGGTGTG TCGGTTGGTG GCGGGTCGTG CCG3GTTGAT GCA.GGCGTTG -70 -
TGGTGTCCGG
CCX3AGTGTGG GTGTCGTTGT CCGTCTGGCG GTGGGATGCT
29040 29100 29160 29220 29280 29340 29400 29460 29520 29580 29640 29700 29760 29820 29880 29940 30000 30060 30120 30180 30240 30300 30360 30420 30480 30540 30600 30660 30720 30780 30840 30900 30960 31020 ----------—(請先閲讀背面之注意事項再填寫本頁) 訂 -線· 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） A7 1237058 B7 五、發明説明（） GGCGGTGCCT GCTGGTGA.GG AGCTGTTGTG GTraTTGTTG GCCX3ATCA.GG GTGA.TCGTGT 31080 GGGGA.TCGCC GCGGTCAACG CTGCX3GGGTC GGTGGTGCTC TCTCGTGATC GGGATGTGCT 31140 CX^TGACCTT GCCGGTCGGC TGGACX3GGCA AGGGA.TCCX3G TCGA.GGTGGT TGCGGGTGTC 31200 GCATGCGTTT CATTCGTATC GGA.TGGA.TCC GATGCTGGCXj GAGTTCGCCG AATTGGCACG 31260 AACCGTGGAT TACCGGCGTT GTGAAGTGCC GATCGTGTCG ACCITGACCG GAGACCTCGA 31320 TGACX3CTGGC AGGATGAGCG GGCCCX3ACTA CTGGGTGCX3T CAGGTGCX3AG AGCCX3GTCCG 31380 CTTCGCCGAC GGTGTCCAGG CX3CTGGTCGA GCACGATGTG GCCACTGTTG TCGAGCTCX3G 31440 TCCGGACGGG GCGTTGTCGG CX3CTGATCCA GGAATGTGTC GCCX3CATCCX3 ATCACX3CCGG 31500 GCGGCTGAGC GCGGTCCCX3G CX3ATGCGCAG GAACCAGGAC GAGGCX3CAGA AGGTGATGAC 31560 GGCCCTGGCA CACGTCCACX? TACGTGGTGG TGCGGTGGAC TGGCGGTCX3T TCTTCGCCGG 31620 TACGGGAGCG AAACAAATCG AGCTGCCCAC CTACGCCTTC CAACGACAGC GGTACTGGCT 31680 GGTGCCATCG GATTCCGGTG ATGTGA.CAGG TGC03GTCTG GCCX3GGGCGG AGCATCCX3CT 31740 GTTGGGTGCT GTGGTGCCGG TCGCGGGTGG TGACXSAGGTG TTGCTGACCX3 GCAGGATTTC 31800 GGTGCGGACX5 CATCCX3TGGC TGGCCXSAACA CCX3GGTGCTG GGTGAAGTGA TCGTTGCGGG 31860 CACCGCGTTG CTGGAGATCG CCTTGCACX3C GGGGGAACX3T CTTGGTTGTG AACX3GGTGGA 31920 AGA.GCTCACC CTGGAAGCAC 03CTGGTCCT GCCX3GAGCGC GGGGCX3ATCC AGGTTCAGCT 31980 GCGAGTGGGC GCGCCCGAGA ATTCCX3GACX3 CAGGCCX3ATG GCGCTGTA1T CACX3CCCCGA 32040 AGGGGCGGCG GAGCATGACT GGACGCGGCA CGCCACGGGC CGGTTGGCGC CAGGCCGCGG 32100 CGAGGCGGCT GGAGACCTGG CCGACTGGCC GGCTCCTGGC GCGCTGCCX3G TO^CCTCGA 32160 CGAATTCTAT CGC3GACCTCG C^GAGCTTGG GCTGGAGTAC GGCCCGATCT TCCAAGGGCT 32220 CAAGGCGGCC TGGCGGCAAG GGGACGAGGT GTACGCCGAA GCCGCGCTGC CGGGAACGGA 32280 AGATTCTGGT TTCGGGGTGC ATCCGGCACT GCTGGACX3CG GCTCTGCACX3 CAACX3GCTGT 32340 CCGAGACATG GATGACX3CAC GCCTGCCX3TT CCAGTGGGAA GGTGTGTCCC TGCACX3CCAA 32400 GGCCGCGCCG GCnTGCGGG TCCGCGTGGT CCCGGCTGGT GACGATGCCA AGTCCCTGCT 32460 GGTTTGTGAT GGCACCGGTC GACCGGTGAT CTCGGTGGAC CGACTCGTAT TGCGGTCGGC 32520 TGCGGCCCGG CGGACCGGTG CGCGCCGACA GGCCCATCAA GCT03GTTGT ACCGGTTGAG 32580 CTGGCCAACG GTTC^CTGC CGACATCCGC TCAGCCA.CCX3 TCCTGCGTGC TTCTCGGCAC 32640 CTCAGAAGTG TCCGCTGACA TACAGGTGTA TCCGGACCTC CXSGTOSTTGA OSGCIOCXSTT 32700 GGATGCCGGT GCCGAACCAC CCGGCGTCGT CATCGCACCC ACGCCCCCCG GCGGTGGACG 32760 AACAGCGGAT GTCCGGGAGA CGACTCGGCA TGCACTCGAC CTGGTACAAG GCTGGCnTC 32820 CGATCAGCGA CTCAACGAAT CCCX^TTGCT CCTGGTGACA O^GGGAGCAG TGGCCX3TGGA 32880 GCCGGGCGAA CCCGTGACCG ATCTGGCGCA GGCCGCGCTC TGGGGACTGC TGCGGTGGAC 32940 GCAGACCGAA CACCCTGA.TC GCTTCGTCCT CX3TCGATGTG GCTGAGCCCG CX3Q^ACTCCT 33000 CCCCGCGCTG CCGGGGGTGC TGGCCTGCX3G OSAACCTCAG CIO3CGTTGC GACGTGGCX3G 33060 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製
1237058 A7 B7 五、發明説明（ 經濟部智慧財產局員工消費合作社印製
CGCTCATGCG CCCAGACTGG CTGGACIGGG CAGCGATGAC GTCCTGCCCX3 TGCCGGACGG CACCGGGTGG CG^TTGGAGG CCACGCGCCC GGGAAGCCTG GATGGG1TGG CATTGGTGGA CX3AACCGACG GCCACX3GCAC CX3CTGGGTGA CGGTGAGGTC AGGATTGCX3A TGCGCGCGGC CGGGGTGAAC TTCCGGGATG CGCTCA.TCGC GCTCGGTATG TATCCCGGTG TGGCATCX3CT GGGCA.GTGAG GGCX3CCX3GGG TCX3TGGTGGA GACCGGCCCC GGCGTCACCX3 GCCTGGCACC CGGCGACCGC GTGATGGGAA TGATCCCGAA GGCGTTCGGG CCGCTCGCGG TCGCCGACCA TCGCATGGTG ACGAGGATTC CCGCTGGTTG GAGCITCGCG CGGGCCGCAT CGGTGCCGAT CGTCTTTCTC ACCGCCTACT ACGCGCTGGT TGATCTCGCC GGGTTGAGAC CAGGGGAGTC GTTGCTGGTT (^TTCGGCCXS CCGGTGGGGT GGGGA.TGGCC GCGATCCAAC TCGCCAGGCA CCTCGGTGCA GAGGTGTACX3 CCACCGCTAG CX3AGGACAAG TGGCAAGCCG TGGAGCTGAG CCGAGAACAC CTCGCITCGT CGCGGACGTG CGATTTCGAG CAGCAGTTCC TCGGGGCAAC CGGCGGACGC GGCGTCGACG TCGTGCTCAA CTCCCTCGCC GGGGAGTTCG CCGATGCGTC TCTGCGAATG CTGCCGCGCG GTGGCCGTIT CCTGGAGTTG GGGAAGACGG ATGTTCGTGA CCCCGTCGAG GTCGCCGATG CGCATCCGGG CGTGTCTTAC CAGGCmCG ATACCGTAGA GGCAGGCCCG CAGCGAATCG GCGAGATGCT TCACGAGCTG GTGGAGTTGT TCGAGGGACG CGTGCTGGAG CCCCTGCCTG TCACGGCITG GGACGTTCGG CAGGCGCCCG AGGCGCTACG GCACCTGAGC C^AGCXSCGGC ATGTGGGAAA GCTGGTGCTC ACCA.TGCCTC CX3GTGTGGGA. O^CGCAGGC ACGGTTCTGG TTACCX3GCX3G AACX3GGAGCA CTTGGCGCAG AGGTCX3CCGG GCACCTCX3TG ATCX3AGCGCG GGGTGCGAAA CCTGGTCCTC GTCAGCA.GGC GCGGTCCCGC AGCCAGTGGC GCK3CTGAGC TCGTGGCGCA ACTGACX3GCC TACGGTGCCX3 AGGTTTCCTT GCAGGCTTGC GATGTCGCCG ATCGTGAGAC CCTGGCX3AAG GTGCTTGCCA GCA.TCCCX3GA CGAGCATCCG TTGACCX3CCG TGGTGCACGC GGCTGGTGTT CTCX3ACX3ACG ATCGCTCACC GTGGAGCX3GC TGGACCAGGT TCTGCX3CCCG AAGGTCGATG CTGATCGACC CGGACGTGGC CCTCGTGTTG TTCTCGTCGG TGTCGGGTGT GGTGGGCAGG GTAACTACX3C GGCGGCCAAC TCCTTCCTCG ACGCATTGGC CAGTCGCX3CX3 GCCTACCGAC GAGZVTCATTG GCCTGGGGGC CCTCGGCGGA ACATGGCATG GCCAGCACCT TGCGCGAAGC CGAGCAGGAT CGATTGGCGC GATCTGGGTT GCTGCC!GATC TCGACCX3AGG AGGGGTTGTC CCAGTTCX3AC GCCGCGTGCG GCGGCX3CGCA TACCGTGGTG GCGCCGGTTC GAITCAGCCG CTTGTCCX3AC GGGAACGCGA TCAAGTTCTC COTCCTGCAA GGTTTGGTCG GGCCX3CATCX3 CGTCAACAAA GCGGCX3ACTG CGGATGATGC 03AGAGCCTC CX3GAAACGGT TGGGACX3CTT GCCX3GATGCA GAACAACATC GGAITCTGCT GGACCTCGTC OSCATGCATG TGGCGGCAGT GCin3GATTC GCCGGTTCTC AGGAGATCAC CGCX3GACGGC ACX5TTCAAGG TGCTGGGCTT CGACTCGTTG ACCGTGGTCG AGTTOCX3CAA CCX3GATCAAC GGGGCGACX3G GGCTGCGACT GCCCGCCACC CICGTGTTCA ACTACCCXSAC
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）
33120 33180 33240 33300 33360 33420 33480 33540 33600 33660 33720 33780 33840 33900 33960 34020 34080 34140 34200 34260 34320 34380 34440 34500 34560 34620 34680 34740 34800 34860 34920 34980 35040 35100 (請先閣讀背面之注意事項再填寫本頁)
經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 發明説明（） GCCGGATGCG CTCGCCGCGC ACCTCGTCAC CGCGCTGTCC GCAGACCGCC TGGCCGGGAC 35160 ATTCGAGGAA CTCX3ACAGGT GGGCX3GCX3AA CCTGCCCACG CIOGCCAGGG ATGAGGCCAC 35220 GCGGGCGCAG ATCACCACCC GGCTACAGGC GATCTTGCAG AGCCTGGCGG ACGTGTCCGG 35280 CX3GAACCX3GC GGCGGCTCCG TGCCGGACCG GCTCAGATCG GCCACX3GACX5 ACGAGCITIT 35340 CCAACTCCTC GACAACGATC TCGAACTTCC CTGATGCCTC AGCCX3GAGCC TTO30\ACTT 35400 CCTGGAGGGA AACX3CCACAT GTCGAATGAA GAGAAGCTCC GGGAGTACTT GCX3GCGTGCX3 35460 CTCGTGGATC TGCACCAGGC GG3CGAGCGG CIXXACGAGG CX3GAGTCGGG AGAGCGGGAA 35520 CCCATCGCX3A TCGTGGCGAT GGGCTGCCX3G TACCCX3GGTG GGGTGCAGGA CCCGGAAGGG 35580 CTGTGGAAAC TGGTCGCCTC CGGTGGCGAC GCCATCGGTG AATTCCCCX3C TGATCGTGGT 35640 TGGCACCTCG ACGAGCTCTA CGATCCCGAC CCGGATCAGC CCGGAACCTG CTACACCCGG 35700 CACGGCGGCT TCCTCCACGA CGCCGGCGAG TTCGACGCGG GATTCTTCGA· CATCAGCCCC 35760 CX3TGAGGCGC TCGCX3ATGGA CCQ3CAGCAG CX3GCTOCTGC TGGAAATCTC CTGGGAGACC 35820 GTCGAATCCX3 CTGGGATGGA CCCX3AGGTCC TTGCX3GGGGA GCCGCACCX3G GGTGTTCGCG 35880 GGATTGATGT ACX3AGGGCTA TGACACCX3GC GCCCACCGGG CA.GGAGAAGG TGTCGAAGGC 35940 TATCTCX3GAA CCX3GCAATGC GGGAAGCX3TC GCCTCTGGTC GGGTTGCGTA TGCX3TTCGGG 36000 TTCGAGGGCC CAGCGGTGAC GGTAGACACG G03TGCTCGT CGTCGTTGGT GGOSCIOCAT 36060 TTGGCGTGTC AGTCGTTGCG GCAGGGCGAG TGTGATCTGG G3CTGGCCGG TGGA.GTGACG 36120 GTGATGTCGA CGCCGGAGAG GTTCGTGGAG TTCTCCCGTC AGCX3TGGTCT CX3CACCX3GAT 36180 GGGCX3GTGTA AGTCGTTCGC GG03GCTGCG GATGGAACCX5 GTTGGGGTGA GGGTGCCGGT 36240 TTGGTGTTGC TXX3^GCGGCT GTCAGACGCC AGGCGGAACG GGCATCGGGT ACTGGCXSGTT 36300 GTTCX3TGGTA GCGCGGTGAA TCAGGACGGT GCGTCX3AACG GATTGACX3GC CCCGAACX3GG 36360 CTGGCCCAGG AGCX3GGTCAT TCAGCAGGTG CTCACX3AGTG CGGGGCTGTC GGCGTCCGA.T 36420 GTGGACGCTG TGGAGGCGCA TGGAACX3GGT ACmSGCTTG GTGATCCGAT CGAGGCGCAG 36480 GCTCTGATAG CCX3CCTATGG ACAGGATCX3G GACCX3GGACC GGCOSCICrG GTTGGGGTCG 36540 GTCAAGTCCA ACATCGGTCA TACGCAGGCX5 GCTGCGGGCG TCX3CTGGTGT GATO^GATG 36600 GTCATGGCGA TGCX3GCACX3G GGAGCTGCCX3 COCACGTTGC ACGTGGA.CGA GCCGAATTCG 36660 CACGTGGACT GGTCGGCTGG TGCX3GTCCGA CTCCTGACCG AGAACATCCG CIOGCCAGGG 36720 ACX3GGTACX3C GCCGCGCTQG AGTGTCGTCG TTCGGGGTAA. GCGGTACCAA CGCACACGTC 36780 ATCCTCGAAC ACGACCCGCT CGCCGTGACC GAGAACGAGG AAGCAGCGCA GTCCCCAGCA 36840 CCTGGGATCX3 TGCCCTGGGC GTTGTCCGGG CX3GTCX3TCGA 03GCX3CTGCX5 GGCCCAGGCC 36900 GAA03GCTGC GCGAGCTGTG CXSAGCAGACC GATCCCGACC CCX3TCGATGT CGGTITCTCA 36960 CTGGCCGCCA CGCGCACGGC TTGGGAGCAC CGAGCGGTGG TGCTTGGTCG GGACAGCGCT 37020 ACGTTGCGCT CCGGGCETGG CGTTGTTGCC AGCGGTGAAC eAGCGGTCGA TGTCGTTGAG 37080 GGGA.GCGTCC TGGACGGCGA GGTCGTCTTC GTCTTCCCCG GT(^GGGCTG GCAGTGGGCC 37140 -73 - 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ：297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） GGTATGGCAG TCGACCTGCT GGACGCTTCG CCGACGTTCG GCCACCGCGC TGCGGAGGTA 03TCGACTGG TCX3TTGGTCG AACTCCCCAC CGCTGGACCG GGTGGACGTG CTCCAGCCCG TCGCTCX3CCX5 AGGTGTGGCX3 TTCCTACGGG GTGAGGCCGG CAAGGCGAAA TCGCCGCGGC CTGCGCAGCC CTTGTCGCAT CIOGCCTGCC CTGCGGATGA GTTGCGGCGA TCAACGGCCC GCGATCGGTC GAACK3CTGG CAGAGTGCX3C TGAAAAGGAC ATGCX3TGCAC GCCTCX3CATT CAGCGCA.CX3T GGAGGTGGTT CX3GAGCCCGG GTGCGACACC GGGACGGCCA GGTGCCX5TGG TGGTCX3ACGG CCX3GCCAGGC TGGACX3GCX3A GTATTGGTAT CX3GAACCTCC CACGCCGTGC AGGGCCTGGT CCGGTGCTGA CCACGGCGGT CX3AGGAAACC GTAGGTACCT TGCGACGTGA GCGTACGTGC GCGGCGCCAC CGTGGACTGG GCCGTGGCGT CTGGACCTGC CGACCTACCC TCCGACGAGG CTCGTGCX3GT CTCX3GACCCG CGCCAAGACC TGAAAAGCGT GTCCGATGCC CTCGATCTCG GCAACACTTC CAGCCCTGTC OTTCTGGCAC 03TCAGGAAC GGTTGGCGGT ACCXSAGTOGA CTGGGTACGG GTGGCCCCGC GAAACCTGGC TCCTGGTCGT TCCCCCGGGC GGCATCGAGG ACGGATGCGT TGAACACX3CG A3GGATCAGC ACCCTGCGCC ACCAGTGGCG AACTCGCAAC CX3AACTCCGC GCCX3CAGCCG ATCCTGTCGC TCACCGCXSOT GGAOSAGCXSA CCCCACCCCG GGGATTGCCT TGCTX3CTGAA CCTGGTCAAG GCX3CTCGGTG CTGTGGACCA TCACGCGTGG TGCGGTCAAG GCAGGCCCCG ATGCAGGCX3C AAGCATGGGG TCTOGGGCGA GTAGCCX3CAC GGTGGGCTGA TCGACCTGCC GGATTCGCTG GACGGCGACG GCXSCTCACCA ACGGCTTGGC GGAAGACCAA OSGCXSACTGG TACCCX3CCCC GGCX3AATCAG CCCX3CTGGAC AGCGCGCTGA TCACGGGCGG GAAATCGGAG C03AGCX3AAT 03TGCTCACC AAGCCGAACT CCX3GGCCCTT -74
CGCGCCACAT ACGTGCTGCG CGTCCTTCGC CGGCCX3TCGT
GATCGGGCGG GCGATCTGGA GCCX3TATCCC
GGACGAGTGC CGGAGCGGAG GGTGATGGTG CGGCCACAGT TGCGGCCAGG CATGGCGTCG CCGTCTGGAA AGCX3GTGGAC CGTCGACTAC
TGATCGGCX3A CTGGGTGGAT GGCA.GCCGGT C03GTTCGAA TCATCGAAAT GAGTGCGCAT CGGAGACCGC CGTGGCCGCG TGTTGCATTC GCTGGCCGAG GGGCCGACGG
AGCCGTGGCG ACGCCGACX3C ACCGCTGAGC CTTGGCAGAC GAGAACGCGG
GCAACCAAGC TGTCCATCGT GGCTTGCX3AC 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐）
ACCGGCGGCG
ACX3GTGACCC AATGCAAGGA AAGCCGACCT CAGATCGGCT TCGAACACCC TCCTCACGAG
CAGAATTCCT
CX3TGCTGGCC 37200 37260 37320 37380 37440 37500 37560 37620 37680 37740 37800 37860 37920 37980 38040 38100 38160 38220 38280 38340 38400 38460 38520 38580 38640 38700 38760 38820 38880 38940 39000 39060 39120 39180 (請先閲讀背面之注意事項再填寫本頁) 訂 1237058 A7 B7 五、發明説明（） GTGACCGA.TC GTGCCX3AGA.T GTCCGCACTA CTGGCCGAGT TCGACXSTCAC CGCGGTGTTC 39240 CACGCGGCCX3 GAGTCGGTCX5 GCIOCTGCCXj TTGGCGGAGA CCGACCA.GAA CGGCCTGGCC 39300 GAAATATGCG CGGCGAAGGT CCGCGGCGCT C^^TGCTGG ACGAACTGTG CGACAGCACC 39360 GA.TCTCGATG CCTTCGTCCT GTTCTCCTCO GGTGCCGGGG TATGGGGCGG GGGCGGTCAG 39420 GGCGCTTACX3 GCGCX3GCGAA OoCATTCTTG GACACACTCG CCX3AACAACX3 CCGAGCACGC 39480 GGTCTGCCGG CAACCTCGAT CTCCTGGGGC AGTTGGGCCX3 GCGGCGGCAT GGCCGACGGC 39540 GCX3GCGGGCG AACACCTGCG GCGACX3CGGG ATACGTCCGA TGCCGGCGGC GTCC3GCCA.TC 39600 CTOGCTCTGC AGGAAGTACT TGACCAGGAT GA.GACGTGCG TGTCGA.TCX3C TGATGTGGAC 39660 TGGGACCGAT TCGTTCCCAC GTTCGCCX3CX3 ACTCGCX3CCA CCCGGTTGTT CX3ACX3AAGTG 39720 CCGGCGGCGA GAAAGGCX3AT GCCCGCGAAT GGGCCGGCAG AACCAGGCGG CTCX3CCGTTC 39780 GCCOSCAATC TCGCGGAGCT GCCGGAAGCC CAACGACX3CC ACX3AACTGGT GGATCTGGTG 39840 TGCX3CCCAGG TGGCAACCX3T GCTCGGGCAC C3GCAGTCGCG AGGAAGTCCA GCCCGAGCX3G 39900 GCGTTCCGCG CGCTCGGGTT CGACTCCCTC ATGGCGGTGG ATCIOCGCAA TCGTTTGACC 39960 ACCGCCACCG GGTTGCGCCT GCCGACCACA ACCGTCTTCX3 40000 ACTACCCX3AA TCCX3GCCGCC TTGGCCX3CTC ACCTOCTCGA GGAGCTGGTG GGTGATGTCG 40060 CGTCGGCTGC GGTGACCGCT GCCAGCGCGC CCGCGAGTGA CGAACCGATC GCGATCGTCG 40120 CGATGAGCTG CCX3GTTTCCG GGTGGCGCGC ACTCGCCX3GA AGACCICTGG 03GCI03TCG 40180 CCGCCGGCAC GGAGGTGATC GGCGAGTTCC CCTCCGACCX3 GGGCTGGGAT GCX3GAAGGCC 40240 TTTACX3ATCC GGATGCTTCC A3GCCTGGAA CX3ACX3TATGC G03GATGGCX5 GGATTCCTCT 40300 ACGACGCCGG TGAGTTCGAT GCCGACCTGT TCGGCATCAG CCCACGTGAG GCGTTGGCGA 40360 TGGATCCGCA GCAGCGGTTG GTGCTCGAAA TCGCCTGGGA AGCCCTCGAA CGGGCCGGAA 40420 TCGATCCGTT GTCCITGAAG GGCAGTGGGG TCGGCACGTA CATCGGCGCT GGAAGCCGTG 40480 GGTACGCGAC GGATGTGCGG C^GTITCCCG AGGAGGCX3GA GGGCTACCTG CTGACX3GGTA 40540 CCTCGGCCAG TGTGCTGTCG GGTCGGGTCG (OTATTCGTT TCGTTTCX3AG GGTCCTGCGG 40600 TCACX3GTGGA TACX3GCTTGT TCGTCGTCGT TGGTGGCGTT GCATCTGGCG TGCCaGTCGT 40660 TGCGTTCGGG CGAGTGTGAT CTGGCGTTGG CCGGTGGTGT GACCGTGATG TCGACGCCGG 40720 AGATGTTCGT GGAGTTCTCC CX3TCAGCGCG GTTTGGCX3CC GGATGGGCX3G TCCAAGTCGT 40780 TCGCGGAGAG CGCGGACGGC ACCGGCTGGG GCGAAGGCGC GGGCCTGTTG TTGCTGGAGC 40840 GGTTCTCGGA. CX3CCCACCX3G AATGGGCA.TC GGGTGTTGGC GGTGGTTCGT GGGTCA.GCX3G 40900 TCAATCAGGA CGGCGCCTCG AACGGACTGG CGGCGCCGAA CGGTCCGTCG CAGCAGCGGG 40960 TCATCAACCA GGCACTCGCX3 AATGCGGCTC TTTCGGCGTC CX3A.TGTGGA.T GCGGTGGAGG 41020 CACATGGCAC CX3GGACCAGG CTGGGTGATC CGA.TCX3AGGC GCAGGCATTG ATCGCAACX3T 41080 ATCGGCAGGC C03GGAGCGG GATCGGCCCT TGTGGCTGGG GTCGGTCAAG TCGAACATCG 41140 GTCATACX3CA GGCCX3CGGCG GGTGTTGCCG GTGTGATCAA GA.TGGTGATG GCCATGCX3GC 41200 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五經濟部智慧財產局員工消費合作社印製 發明説明（）
ACX3GGCAGCT GCCCGCCTCX3 CIOCACX3CGG ATGAGCCCAC GTCGGAGGTC GATTCGTCGT CGGGGGCX3GT CCGGCTCCTC GCCGAACAGG TACCTTGGCC GGAGTCTGAC COTGTTCX3TC GGGTGGGGGT TTCGTCGTTC GGGATCAGCG GCACCAACX3C ACA.TGTGATC CTCXSAACAAG CTAOSAATGC GCCAGATAGT ACAGCGGA.GA CX3GACAAAAC AGAATCCGGA TCTACTGTCX5 ATATTCCX3GT CGTTCCCTGG TTGGTGTCX3G GAAAGACGAC GGA.TTCCCTG CX3GGGACAAG CCX3AACGAGT CITCTCTCAG GTCGAGTCCC GGC03GAGCA GOTTTCX3CTG GA.TGTTGCCT ACTCGCTTGC TTCTGGCCGA GCCGCGCTGG ATGAACGCGC TGTCGTGCTG GGTGCGGACC GCX3GTGAGCT GGTIOCTGGA CTGGCX3GG3T TGGCCX3CCGG TCAGCX3GAAC TCGTGCTTCT GCTCGGTTCG GGTTOGTGTT GGTTGGGGAT GGGCAGAGCG CTCTACTCX3A AGTTTCCGGT AGGCTTGCGC CGAGTTGGAG GCACATCTGG GGGAAGACCG TCGGTTCCGA TGCGCAGCTG CTGGATCAGA CGCTGTGGGC TGCAAGCCGG CCTCITGGGG CTCCTrGGGTr CX3TGGGGCGT TCGGCCGGAT GTGGTGATGG GGCATTCGGT CGGGGAGTTG GCCX3CCX3CX3T TTGCX3GCTGG CGTGTTGTC!G TTGCGGGATG CGGCTCGGTT GGTGGCCX3CG CX3CGCCCGGT TGATGCAAGC CCTGCCCTCT GACGGCX3CGA TGTTGGCGGT GGCTCCTGGT GAAGACCTTG TTCXSGCCAIT GCTGGCCX3GT CX3GGAGGAGT CCGTGAGCGT OSGCGCGCTC AATGCCCCCG GTTCX3GTGGT GTTGTCGGGC GATCGGGAGG TGCTGGCCAG CATCGTCGGC CX3GCTGACCG AGCTCCX3AGT CCGGACGCGG CX3CTTGCGC3G TCTCCCATGC TTTTCATTCX3 CACCX3GATGG ACCCGATGTT GGGCGAGTTC GCCCA.GATCO CCGAGTCTGC GGAGTTCGGT AAGCCAACGA CACCX3CTTGT GTCX3ACX3TTG ACGGGTGAGC TCX^CAGAGC CGCX3GAAATG AGCACACCAG GGTATTGGGT GCGCCAGGCX3 CGTGAACCCG TCCGTTTCGC CGACGGTGTC CAGGCCCTGG CAGCGCAGGG CATAGGCACG GTCGTCGAGC TCX3GCCCC3GA CGGAACGCTG GCXX3CACTGG TTCGGGAGTG TGCGACCGAG TCCGATCGGG TTOGGCGGAT TTCGTCGATC CCACTGATGC GCAGGGAGCX3 GGACGAGACC TCACAGCCCT GGCGCATCTC CACACCCX3TG GTGGTGAGGT GGACTGGCAG CCX3GTACCGG CX3CTAGGCAG CTCGAGTTGC CAACGTATGC CTTCCAACXSA O^GCACTACT GGATCGAGTC CAGTGCGCGG CCAGCACX3CG ACOSCXSCAGA CATCX3GCGAG GTGGCGGAAC AGTTCTGGAC CGCGGTTGAC CAAGGCGATC TGGCAACGTT GGTCGCCGCT CTGGATCTTG GGGCGGACGA CGACACATGC GCATCGTTGA GCGATGTATT GCCGGCGTTG TCCTCCTGGC GAAGCGGACT CCGCAACCGT TCGCTCGTCG ATTCCTGCCG GTACCGAATC ΑΟΤΙΟΧΑΓΓ CCTCTCX3GGA GGTGCCX3GCC CCGAAGATTT CCGGTACCTG GCIOTTGGTC GTGCCCGGTG CTGCGGATGA CGGATTGGTC ACGGCTTTGA CGAGTTCACT GGTCGGAGGC GGCGCCGAGG TCGTCCGGAT CGGCCTGTCC GAAGAGGACC CGCACCGCGA GGACGTCGCA CAGCGGCTGG CCAATGCGCT GACGGATGCC GGTCAACTCG GTGGCGTGCT TTCGCTGTTG GGGCTCGATG
GCGTTTGATG
GATGTGGTCT
41260 41320 41380 41440 41500 41560 41620 41680 41740 41800 41860 41920 41980 42040 42100 42160 42220 42280 42340 42400 42460 42520 42580 42640 42700 42760 42820 42880 42940 43000 43060 43120 43180 43240 (請先閲讀背面之注意事項再填寫本頁) 訂 線!· 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 a7 B7 五 ._I___ 經濟部智慧財產局員工消費合作社印製 發明説明（）
AAT03CCTGC TCCGGGATTC TCCIOCTTGC CAACTOSTTT CGCGCTGACT GTGCAGCTTC TGCX3GGCCTT GCGGAAGGCC GACGTCGAGG CGCCTTETTG GGCGGTCACG TCGCGTTGGA AGATGTACGC GTGTCTCCGG AGCAGGCCCT GGTCTGGGGG TCX3CGGGACT GGAGCACCCG GAGTTCTGGG GTCGCITGAT CGACCTGCCA ACGACCGATT GGGTGCCCGG TTGGCX3GGTG TGTTGGCGGA TGGTGGCX3AG CCATTCGCCG TGGTGGTGTG TTCX3TGCGGC GGTTGGAACX3 CX3CTGGTGCG GGTCX3GTGTG GCGTCCTCGG GGGACX3GTGT TGGTGACGGG TGGTACGGGC CGCATGTTGC CCGGTGGTTG GCCGGTGCCG GGGCTGAGCA CGTGGTGTTG GAGGAGCGGA CGCTCCX3GGC GCTGGGGAAT TGCX3GGCGGA GCTGGAGGCG GGGTGTCGAT TGTGCCCTGC GACGTGGCTG ATCX3TGACGC AGTGGCTGGA GGATCGGTGG GGAGTGTCCG CTGACTGCGG TGGTACACGC CGCCGGGGTC GCGACGTAGT GGAGATGGGT TTGGCX3GATT TTGCAGCX3GT GTTGTCGGCG GTGCGGCGAA TCTGGACGAG TTGCTGGCCG ACTCX3GAGCT GGATGCX3TTT CCTCGGTGTC GGGGGTGTGG GGAGCCGGCG GACAGGGTGC GTATGCGGCT ACTTGGATGC GTTGGCCGAG CAGCGTCGGG CGAGGGGATT GGTCGGGACC GGGGACCGTG GGCCX3GTGAC GGCATGGCC!G CCGGCGAAAC CGGCGCA.CAG TGGGCCTGGC GTCX3ATGGAA CCX3AGCGCGG CXXJTGCTGGC ACTTCAGGGT GCGA.TGAGAC CTCCCTCGTC GTGGCCGA.TG TCX^TTGGGC ACX3GTTCX3CC CCTCX3GCACX5 TCGACGCCCG CTGCTGGACA CCATCGACGA C3GCCCGAGCC CCACCX3GCGA AO^CGGGC ACAGGCAAAC CCGTTGAGCT GACGCAACGC TGTCGCX3GAA GGAACGCGAC GATGCX3GTAT TGGATCTGGT GCX3GGCGGAG TGCTGGGACG CX3ACGATGCC A03GCCCTGG CGCCATCGCX3 GCCX3TTCCAG TCX^CTCCTT GA.TGGCGGTG GAGCTGCGCA ACCGGCTGAA CACCGCCACC TGCCCX3CCAG CACGATTTTC GACTACCCCA ATGCCXSAGTC GCTGTCGCX3T CCGAGCTTTT CCCAACGGAG ACTACCX3TGG ACTCGGCCCT TGCCGAGCTC AGCAGCAGCT CTCGATGCTC ACCX3GCX3AAG CGCX3GGCACG GGACCGAATC TGCX3AGCCCT CCACGAGAAG TGGAACAGCG CAGCTGAAGT ACCX3ACCX3GA TGAGCACGCT CGATTCX3GCG ACGCACGACX3 AGATATTCX3A GTTCATCGAC ACCTGTCCTG AGCAGTTCCT GCGGAACITC AAGCX3CCGAA ATCX3GGTGGA GCCAATGAAG AAAAGCTCTT aSGCTATCTG AAGAAGGTAA CIOOSGACCT CGGCAGCGCC TGCTCGCGGC CGAGAGCCGG AGTCAGGAGC CGATCGCGAT AGCTGCCGAC TGCCCGGCX3G OTTCGACTCT CCCX3AAGCX3C TCTGGCAACT GGCACCGACX3 CCATCTCGGA GTTCCCCGCC GACCX3GGGCT GGGMXTTCGG CCX3GTTGTAC
TCGGACTGGG GATCAAGTCG TCGGGTGCCG
ACCAGCCGTC
GTGATGTTCT GCX3AACGCCT
CTGCACCGGA GCATTGGACC CCAGCCTTCA GCA.TTGGAAA
ACX3GCX3GCTG GAACTCGGAT GGGATCCAGC CACCTCTGCG GATCGAATCG GCGACACGAC GCCGATGTCC AACGAGCTCG AATCACAATG GCATCAGACC
GATCCCGACC CX3AACCA.CCA \CGTCG TACACGCGGG -77 - 43300 43360 43420 43480 43540 43600 43660 43720 43780 43840 43900 43960 44020 44080 44140 44200 44260 44320 44380 44440 44500 44560 44620 44680 44740 44800 44860 44920 44980 45040 45100 45160 45220 45280 (請先閱讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（） 經濟部智慧財產局員工消費合作社印製
GCGGGCGATT TCGACCCCX3C CATGTTCX3GG ATTTCGCCGC GTGAGGCGTT GGaSATGGAC CCGCA.GCAAC GGTTGTTGCT GGAGCTGTCC TGGGAGGCCC TCGAACGGGC GGGCATAGA.C CCGACATCCC TGCGCGGCAG CAAGA.CCGGT GTCTTCGGTG GTGTCACGCC CCAGGAGTAC GGGCCGTCCT TGCAGGA.GAT GAGCCGAAAC GCTGGGGGTT TTGGA.CTCAC OjGGCGGAIO GTGA.GTGTGG CGTCX3GGTCG GGTTGCGTAT TOTTTTGGTT TTQA.GGGTCC TGCGGTGA.CG GTGGATACGG CGTGTTCGTC GTCGTTGGTG GCCCTGCATT TGGCGTGTCA. GTCGTTGCGT TCCGGCX3AAT GCGATCTCGC GCTGGCCGGC GGTGTGACX3G TGATGGCGAC ACCGGCGACG TTCGTGGA.GT TCTCCCGTCA GCGTGGTTTG GCTCCGGAC!G GGCGGTGCAA GTCGTTCGCX3 GCTGCCX3CGG ATGGCACCGG GTGGGGTGAG GGTGCCX3GTC TGGTGTTGCT GGAGCGG1TG T03GA.TGCGC GGCX3GAATGG GCACGAGGTT CTGGCX3GTGG TGCX3GGGTAG CGCX3GTGAAC CAGGACGGCG CGTCGAATGG TTTGACTGCG CCGAATGGTC CGTCGCAGCA GCGGGTGATC ACCCAGGCX5T TGGCGAGTGC GGGGCTGTCX5 GTITCCX3ATG TGGATGCGGT CX3AGGCACAT GGGACCGGGA CCACGTTGGG TGATCCXSATC GAGGCACAGG CCCTGATCGC CACGTACX3GG CAGGGCCGGG AGAAGGATCG GCCX3TTGTGG TTGGGGTCX3G TCAAGTCCAA CATCGGTCAC ACGCAGGCGG CCGCTGGCGT TGCCGGCGTC ATCAAGATGG TCTTGGCGAT GCGGCACGGG CAGCTGCCCG CCACGTTGCA TGTGGATGAG CCCACGTCGG CGGTGGACTG GTCGGCGGGT TCC3GTCCGGC TTCTCACGGA GAACACGCCC TGGCCX3GA.CA GTGGTCX3TCC TTGCCGGGTG GGGGTGTCX3T CX3TTCX3GGAT CAGCGGCACC AACXSCACATG TGATTCTCGA ACAGTCTCCA GTCX3AGCAGG GCGAACCGGC CGGGCCGGTC GAAGGCGAGC GGGAACCGGA TGTAGCCX3TC CCCGTGGTGC CITGGGTGCT GTCGGGTAAG ACACC!GGAGG CTGCmSGGC GCAGGCCGAA OSGGTGCATT aSOVTATCGA GGACCGGCCG GGGCTGTCGC CGGTGGATGT GGCX3TATTCG CTAGGAATGA CACX3CGCGGC GCTGGATGAA Q3CGCAGTGG TGTTGGGCTC GGACCX3TGCC GCGCTCCTGA CCX3GGTTGAG GGCATTCGCC GA03GCTGCX3 ATGCGCCCGA AGTGGTTTCX3 GGGTCTGTGG GGCTTGGTGG CCX3CGTCGGG TTCGTGTTCT OX^TCAGGG TGGTCAGTGG CCGGGGATGG GCCX3GGGGCT CTACTCGGTG TTTCCX3GTGT TCGCCX3ACGC GTTCGACGAG GCTTGCGCGG AGITGGA.TGC ACACCTGGGC G^GGAACTGC GC3GTTCX3GGA TGTGGTGTTC C3GTTCGCAAG CGTGGTTGCT GGATCGGACG GTGTGGGCGC AGTCXSGGTIT CAGATTGGCT TGCTGCGGCT GCTGGGTTCG TGGGGTGTTC GGCCX3GATGT CACTCGGTGG GTGAGCTGGC TGCGGTGCAT GCGGCTGGTG TGTTGTCXSTT GTCGGAGGCC GCGCGGTTGG TGGCGGGTCX5 CGCCCGGTTG ATGCAGGCGT TGCCTTCTGG TGGTGCCATG CTCGCX3GTCG CTACGGGTGA. GTTTCAGGTC GATCCTCTGC TGGATGGGGT GCGGGACCX3G ATCX3GTATCG CGGCGGTGAA TGGCCCX3GAA TCGGTTGTGC TCTCTGGTGA. CCm〇AGCTG CTCACCX3AGA T(XCTGATCG GTTGCACGAT CAGGGGTGCC GGACCCGGTG GTTGCGGGTG TCGCATGCTT TCCATTCGCC CCATATGGAG CCGA.TGCTGG AGGAGTTCGC CO^TCTCC
45340 45400 45460 45520 45580 45640 45700 45760 45820 45880 45940 46000 46060 46120 46180 46240 46300 46360 46420 46480 46540 46600 46660 46720 46780 46840 46900 46960 47020 47080 47140 47200 47260 47320 (請先閱讀背面之注意事項再填寫本頁)
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 5經濟部智慧財產局員工消費合作社印製 發明説明（
CGAGGCCGCG AATATCACGC ACCGGAACTG CCGATCATCT CGACCCTGAT CGGTGAGCTG GACGGTGGTC GAGTGATGGG CACTCCCGAG TACTGGGTGC GTCAGGTGCG TGAGCCCGTC GGCGCTTGTC GGTCA.GGGTG TCX3GCA.CGAT TGTCGAATTG GAGGAGTGTG TGGCX3GAATC CGGGCGGGTG GCCGGGATCC CX3CTOATGCG CAAGGACCX3C GACGAGGCX3C GAACCGTGCT GGCAGCTTTG G03CAGA.TCC ACACCCGTGG TGGTGAGGTG GACTGGCGGT CGTTTTTCGC CGGTACCGGG GCGAA.GCAAG TCGACCTGCC CACCTACGCC TTCCAGCGGC AGCGGTACTG GCTGGCATCC ACCX3GGCGTG CGGGTGACX3T GACCGCCX3CC GGATTGGCCX3 AGGCGGACCA TCCGCTGCTC GGTGCGGTGG TTCCGTTGGC AGACGGCX3AA GGTGTGGTGC TGACCGGTCO GTTGACAGCX3 GGTTCGCATC CGTGGTTGTC CGATCACCGG GTGCTGGGCG AAATCGTCGT CCCCGGCACC GCX3ATCGTCX3 AGCTGGTGTG GCACGTCGGC GAGCGCCTCX3 GTTGTGGCCG CTGGCTTTGG AAGCGCCCCT GATCCTGCCG GATCATGGAG GTGGGACCGC CCGGGGAATC CGGAGCCCGG TCGGTGGCGC TCTACTCCTG TCCTGGCGAG GCGATCGAAC CCGAGTGGAA GAAGCACGCG ACGGGCX3TGC TTCTCCCACC CGTGGCCX3CC GAGAACCATG AGCTGACCX3C ATGGCCCCCX5 GAGAATGCXSA CCX3AAATCX3A TGCAGACGGG GTCTACGCAT TCCTTGAAGG GCACGGTTTC GCGTACGGAC CGGCCTTTAG ATGTCTGCGC GGTGCCTGGC GACX3AGGCGG GGAGGTGTTC GCCGAAGTCG CATTGCCGGA TGACA.TGCAG GCGGGGGTCG ATCGATTCGG CGTCCACCCC GCGTTGCTGG ACGCGGTTCT GCATGCCGCC GCAGCCGAGA CGTCGGTGGT CC^GAGCGAA GCGCGGGTGC CGTTCTCGTG GCGTGGGGTG GAACTTCGCG CCACTGAAAG CGCGGTGGTG CX3GGCX3CGCC TCTCGITGAC TTCGGATGAC GAACTGTCX3T TGGTCGCAGT GGACCCGGCT GGCCX3ATTCG TGGCCACGGT TGATTCXSCTG GTGACCCGAC CX3ATCTCCCG GCAGCAGGTG AGGTCTGGCG CX3A.TCX3GTGA TTGCCTGTTC GAGGTGGAGT GGCACCX3GAA GGCGTTGTTG GGAACAACCG CCX3GCX3ACX3A CCTTGCCATC GTCGGTGACG GTCCCAGTTG GCCGGAATCG GTGCGCX3CAA CCGCACX3GTT CGCGACCCTG GATGAGITCC GTGCGGCCX5T GGA.CTCGGAC GTTCCTGCCC CGGGTTCGGT
47380 47440 47500 47560 47620 47680 47740 47800 47860 47920 47980 48040 48100 48160 48220 48280 48340 48400 48460 48520 48580 48640 48700 48760 48820 48880 48940 49000 49060 49120 49180 49240 49300 49360 (請先閱讀背面之注意事項再填寫本頁) 訂 線!·_
AGAGTCGACC CGAATCCCAG ATTCGGACGT CGCGGACCTG TCAGCCCAGT CX3GA.GAACCC
GCTATGTCGG CCX3AAGAGGT TCCGATCTGC CTCGTGGTCG TCACGCGTGC CGTCGTGGGG ACGTGGACGG CACACCTGAG GCAGGAGAAC CTCACGGTGC GCGAGGAGGG CTCCTCCCCG CAACTCGACA CGGACGGGAC CGTCCTCATC ACGGGTGGCA CCGGTGCGTT GGGGGGAGTG GTTGCCCXSTC ACCTGGTGGA. GGA.GCACX3GG ATTCX3GCGTT TGGTGTTGGC AGGCCX3GCGT C3GCTGGAATG O^CTGGAGT CCACX3AGTTG
本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） 經濟部智慧財產局員工消費合作社印製 1237058 at B7 發明説明（） GTGGATGAGC TGGCGCGCGC GGGCGCCGTG GTTGAGGTGG TGGCCTGCXSA TGTCGCIOAC 49420 CGCACCGATC TGGA.GCACX5T GCTGGCCGCC ATTCCGGTCG ACTGGCCX3CT GCGGGGGATC 49480 GTGCA.TACCX3 CTGGGGTGCT GGCCGACGGA GTGATCGGGT CCITGTCX3GC GGCGGA.TCTC 49540 GGCACGGTGT TTGCCCCGAA GGTGACX3GGG GCATGGCATC TGCACGAGTT GACCCX3CGAT 49600 CTGGATCTGT CGTTCTTCGT TCTTTTCTCT TCCITCTCCG GGATTGCX3GG TGCCX3CAGGG 49660 CAGGCCAACT A03CGGCX3GC GAACACOTTC CTX3GA.TGCAT TGG03CGTTA TCGCCGGGCG 49720 CGTGGGCTGC CIOX5TTGTC GTTGGCGTGG GGACTGTGGG CX3CAACCCAG CGGTATGACG 49780 AGTGGCTTGG ACGCGGCCTC GGTGGAGCGG TTGGCGCX3GA CX3GGCATCGC AGAACITTCC 49840 ACGGAGGATG GACTCCGCCT GTTCGATGCC GCGTTCGCGA AGGACCGGGC ITGCGTCGTT 49900 GCCX3CTCGAT TGGACAGGGC GCTX3CTGGTC GGGAACX3GAC GATCGCACXSC GATTCCGGCG 49960 CTGTTGAGC!G CX3TTGGTTCC TGTTCGCGGC GGTGTGGCX3A GGAAAACAGC CAATTCTCAG 50020 GCCX3CGGATG AGGACX3CACT GTTGGGTTTG GTGCX3GGAGC ACGTTTCGGC CX5TGCTGGGT 50080 TATTCGGGTG CGGTCGAGGT TGGGGGCGAC CGTGCTTTCC GTGATCTGGG TTrTGATTCG 50140 TTGTCTGGCG TGGAGTTGCG GAACCX3CCTT GCCGGGGTGC TGGGGGTGCX3 GTTGCCGGCG 50200 ACTGCGGTGT TCGACTATCC GACGCCGCGG GCGCTGGCGC GTTTCCTGCA TCAGGAACTG 50260 GCAGGCGAGG TCGCGTCCAC GTCGACGCCG GTGACCAGGG CAGCGAGTGC CGAAGAGGAT 50320 CITGTTGCGA TTGTCGGGAT GGGATGTCGT TTTCCGGGTG GGGTGTCX3TC GCCX3GAGGAG 50380 CTTTQGCGGC TGGTGGCCX3G CX3GCGTGGAT GCGGTGGCTG GGTTCCCAGA OGATCGOGGC 50440 TGGGATCTCG CGGCGTTGTA CGATCCTGAT CCCGA.TCX3TC TCGGGACCTC GTATGTGTGT 50500 GAGGGCGGGT TTCTGCGGGA a303GCGGAG ITCX3ATGCTG ACATGTTCX3G CATCAGCCCG 50560 CGTGAGGCGT TGGCGATGGA TCC!GCAGCAG CX^TTGCTGC TGG^GGTCGC CTGGGAAACC 50620 TTGGAGCGGG CTGGGATCGA TCCGTTCTCG TIGCACGGCA GCCGGACCGG TGTGTTCGCG 50680 GGCITGATGT ACCACGACTA TGGGGCCCX3A TTCATTACCA GA.GCACCGGA GGGCTTCGAA 50740 GGGCACCTCX3 GGACX3GGCAA TGCGGGGAGC GTGCTGTCGG GTCGGGTTGC GTATTCXSTIT 50800 GGTTTCGAGG GTCCTGCGGT GACGGTGGAT ACGGCOTGTT CGTCGTCX3TT GGTGGCX3TTA 50860 CACCTGGCGG GTCAAGCACT GCGGGCCGGT GAGTGCX3AAT TCGCCCTTGC CX3GTGGCGTC 50920 ACGGTGATGT CGACGCCGAC GACGTTCGTG GAGTTCTCCC GTCAACGGGG TCTGGCTCCG 50980 GA.TGGGCGGT GCAAGTCGTT CX3CGGCGGCC GCX3GATGGCA CCGGGTGGGG CX3AGGGTGCC 51040 GGTCTGGTGT TGCTGGAGCG GTTGTCGGAT GCCCGGCX3CA ATGGGCACX3A GGTTCTGGCX3 51100 GTGGTGCX3GG GTAGCGCGGT GAACCAGGAC GGCGCGTCX3A ATGGCTTGAC TGCGCCAAAT 51160 GGTCCX3TCAC AGCAAAGGGT GATCACCCAG GCACTCACGA GTGCCX3GGCT GTCCX5TGTCC 51220 GACX3TGGATG CTGTGGAGGC GCATGGGACX3 GGCA.CX3CGGC TTGGTGA.TCC GZVTOSAGGCG 51280 CAGGCGTTGA TCGCTACGTA CGGCCGGGAT CGTGATCCCG GTCGGCCGTT GTGGCTGGGG 51340 TCGGTGAAGT CGAATA1TGG TCACACCCAG GCX3GCGGCX3G GTGTCGCTGG TGTGATCAAG 51400 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
1237058 A7 B7 五、發明説明（）
ATGGTGA.TGG CGATGCGGCA GGGGGA.GCTG CCGCGCACOT TGCACGTCGA GCGCAGGTGG ACTGGTCTGC GGGCACGGTC CAACTCCTCA 03GAGAACA.C GACAGCX3GTC GTCTTCGCCG GGCGGGCX5TG TCATCOTTCG GGATCA.GTGG CACCTGATCC TTGAACAACC TCCGCGAGAG TCGCAGCGCT CAACAGAGCC TCTGTCCGCG ATTTTCCX3GT GGTGCCX3TGG ATGGTGTCX3G GCAAAACACC TCCX3CCCAGG CAGATGCATT GATGTCCTAC TTGAGCAATC GCGTTGA.TGC GATATCGGTT ATTCGCTTGC GGTGACCCGT CCGGCGTTGG ACCACCGCGC GGTGCGGATC GTGCCX3CGTT GCTGCCX3GGC TTGAAAGCGC TGGCCGTTAG GCCGAGGTGA TCACCGGCAC TCGTGCCGCT GGGCCGGTCG GATTCGTGTT GGTGGTCAGT GGCCCGGGAT GGGAAGCGGG CTCCACTCGG OTTTTCCGGT GCGTTTGACG AAGCCTGCTG CGAGCTGGAT GCGCATCTCG GGCAGATGGC GATGTGTTGT CCGGTTCX3GA TACX3CAACTT CTGGACCAGA. CTGTTCGCGT TGCAAGTCGG ACTCTGGGAG TTGTTGGGTT GTGGTGCTGG GCCACTCX3GT CX3GTGA.GCTG GCX3GCX3GCGT TTGCGGGATG CGGCTCGGCT GGTGGCX3GGC CGTGCCCGGT TGA.TGCAAGC GGCGGTGCCA TGCT03CTGC GGCTGCTGGA GAGGAGCAGC TGCGCCCX3TT TGCGGTGATC GTGTGGGGAT CX3CCX3CX3GTC AACX3CTCCCG GATCGGGATG TGCTCGATGA CATTGCCGGT CX3GCTGGACG GGC^GGGAT TTTCGCATGC GTTTCATTCG CATCGGATGG ATCCGATGCT
CGAGCCCTCC GCCCTGGCCC CACCAACGCG GGATTCX3GGT CX3AAGCGCTA TTCCCCGCGA TGTCGTGCTG TAATGACX3CT CTCCGGTCAA GTTCGCCX3AC CCGGCTACGA
GCAGCCX3GGC
CCTGCCAACT GCTGGCCX3AC
GTCGACGTTG 經濟部智慧財產局員工消費合作社印製
ACCGAAATCG CCCGGAGCGT GGACTACCGG ACGGGTGAGC TCGA.TGAGGT 03GCATGCCX5 CGAGAACCCG TCCGCTTCGC CGACGGTGTT GTCGTCGAGG TCGGTCCGGA TGGGGTGITG TCCGATCAGG GCGGACGGGT GGCCGCGGTT CCGCTCATGC GCAGCAATCG CACACGGTGA CAACGGCATT GGCGCAGATC CATGTGCGTG TCGTTTTTCG CCX3GTACCGG GGCAAAGCAG GTCOAGCTGC CCACGTATGC C^GCXSGTACT GGCITGA.CTC ACCATCCGAA CCGGTCGGGC AATCCGCCX3A CAGTCGGGCT TCTGGGAACT COTOSAGCAG GAAGATGTCA GCGCX3CTCAG CACATTACCG GCGATCACGA OTTGCAGGCG TCCCTGGAAT CGGTGGTTCC TCCTGGCATC GCCGGATCCG CAACGAATCC CTGGTGCACC AGTGGCGGTA TGGCATGAGC GGGCAGATTT GCCAGACCCC TCGTTGTCGG GGACATGGCT
TGCCGATCGT AGTATTGGGT CGGCTCACX3G
TGTGAGCACC
CTTCCAACX3A TCCCGCGCGC CGCCGCTCTG GGTCCTCTCC CCGGATITCC
CCX3GAGGGGT GGTCGGCX3AG GGTTGCCCGG CAGTTCTGTT TTCCGCTCGT TGCCTGTTGC
ACGA.GATGTT GGGCACGACG AGGAAGCCCT ATAAGCX3GCG TGTTGTCCIT -81 -
CGAGGAACGG
51460 51520 51580 51640 51700 51760 51820 51880 51940 52000 52060 52120 52180 52240 52300 52360 52420 52480 52540 52600 52660 52720 52780 52840 52900 52960 53020 53080 53140 53200 53260 53320 53380 53440 (請先閱讀背面之注意事項再填寫本頁) 訂 •線I·· 本紙張尺度適用中國國家標準（CNS ) A4規格（210X：Z97公釐） 1237058 A7 B7 五、發明説明（） 經濟部智慧財產局員工消費合作社印製
GATGAATCGC CGTCCTCGCC GAAOSCTGCT TTGCCGAATG CTGCTGCGAG CTCTGCGGGC CGCGGATGTG TCGGCGCCAT GGTGTCX3CX3G TCGGGGATGT GCCGGTGAAC CCX3GGGCAGG CGCGTCX3TCG GTCTGGAGCA TCCGGCCTGG TGGGGTGGCC CTCGATGAGG ACGCTCGAGA ACGCTTGTCG ATCGCGGTAC GTCCCGGTGG TGTGTTCGTG CGGCGGTTGG GGTGCCGGGT CGGTGTGGCG TCCTCX3GGGG ACX3GTGTTGG TTGGGGGCGC ATGTTGCCCX3 GTGGTTGGCG GGTGCCGGGG AGCCGTCGAG GCX3CGGCGGC TCCX3GGCX3CT GGAGATTTGC GGCGCTCGGG TTTCGATCAC GGCCTGCGAC GTGGCCGATC TTGGCX3ACCA TTCCGGATGA TTGCCCX3CTG ACCX3CGGTGA GAAGTCX3GCG ACX3TGGCGTC GATGTGTTTG ACCGACTTCX3 GCAGGTGGTG CGGCGAATCT CX3ATGAGTTG CTCGCCGATG CTGTTCTCAT CCGTCTCGGG TGTGTGGGGT AATGCCTACT TGGATGCX3TT GGCGCAGCAG GTTGCGTGGG GCCCGTGGGC CX3GTGACGGA ATGGCCGCAG CGCCGGGCCG GCCTGGTGCC AATGGCTGCG GATCGGGCGT 1TGGATCX3TG ACX3AGACATC CCTGGTCGTG GCCGATATGG GTGTTCX3CCA TGTCCCGTCG GCGTCCGCTG CTCGACGAGC TTGGCGGATG CGGAGAACAC CACTGATGCT GCX3GACTCGG GCGGGCATGG CAGCCGCCGA ACGCCGCCGC GCGATGCTGG TCGATTGTGT TGGGACACAA CGGGTCTGAC CCAG1TGGTC CTCGGATTTG ATTCGCTGAT GGCCGTCGAA TTGAGTCTGC CGGCCACGTT GATCTTCGAT TATCCX3AGCC CTGGTCX3GCG AGCTGGTGGG AGCGCAGCCC GCGACCACCG GTGGATGATC CGGTTGTCGT GGTCX3CGATG GGATGCCX3GT CCQ3AGGAGC TGTGGCAGCT GGTTTCTGCG GGACGTGATG GATCGGGGTT GGGACTGCAA CACGTTGTTC GACCCGGATC TATGTGCX3AG AAGGTGCCTT CCTGACCGGT GCTGATCGGT ATCAGCCCTC GCGAGGCGCG CGCAATGGAT CCGCAGCAGA TGGGAGGTTT TCGAACGAGC AGGAATCGCT CCGCTGTCGT GTGTTCGCX3G GGACCAATGG GCAGGACCAC GGTGCX3AAAG GCGGGTCACC TCCTGACCX3G AAACGCCGCX5 AGTGTCCTGG TTCGGCCTTG AGGGGCCTGC GGTGGCGGTG GATACCGCGT
本紙張尺度適用中國國家標準（CNS ) A4規格（210297公釐）
TGGTCGACGT
TGACGGGTGG CTGAGCATGT
CTCGTTGGTA GACGTGTGGT GGGACTGGGT GCCGTGCITG CGAGGACGAG TGCGGCGTCG TACGGGCGGT GGTGTTGACC
GTGACGCTTT TGCATGCGGC
GGCCX3AAGTG GGGGGTCGTT
GGGGACTGCG
TGCACAGCTG
TGCTGGCACT CGTGGGAGAG TGCCCGAAGC CCGTCCCGCT ACCTGGTGCT CCGACCGGGC GGTTGGGCGA CATCCGCGCT TCGTGGCCGG ATCCGGGCGA CGGTATCGAC CGGATCGGGC
ACAGCAGGCG ACCGCGGCTC
C3GCAACAGGA GGCTGA.GCAG GGCCGATCCA CGTCTGCTCG GTTCCCCGTC AGGCAGTACC
TCGACGCCGG
CAGGACCGGT
TGGCTGCCGC CCGGCCGGCT GTTCGTCGTC
GCCX3GAGGCG TTCCTACACG GTTGGTGGCG 53500 53560 53620 53680 53740 53800 53860 53920 53980 54040 54100 54160 54220 54280 54340 54400 54460 54520 54580 54640 54700 54760 54820 54880 54940 55000 55060 55120 55180 55240 55300 55360 55420 55480 (請先閲讀背面之注意事項再填寫本頁) '、?τ 1237058 A7 B7 五、發明説明（） 經濟部智慧財產局員工消費合作社印製
TTGCATTTGG GTGACGGTGA TGTCX3ACACC CCIOGCTTTC CTCGAGTTCT CCAGATGGTC GGTGCAAGTC GTTTGCX3GCC GCTGCGGATG GCCX3GCCTGG TGTTGCTGGA GCGGTTGTCG GA.TGCTCX3TC GCCX3TGGTTC GCGGGTCTGC GGTGAATCAG GATGGTGCGT AATGGTCCGT CGCAGCAGCG GGTGATTCGG CAGGCCCTCO TCCGATGTGG ATGTCGTGGA GGCGCACX3GG ACCX3GTACCG GCX3CAGGCX3C TGATCX3CGAC ATATGGGCAG GAGCGGGATC GGGTCX3ATCA AGTCCAACAT CGGCCACACG AAGATGGTGC AGGCCA.TGCX3 GCACX3GGGAG ACTCCACAGG TGGACTGGTC TGCCX3GGGCC CCCGAGAGCG GCCGTCCTCG TCGAGCGGGG GTGTCGTCGT GCACACCTCA TCCTCGAACA ACCACCX3TCG GAACCAGCGG CGGGTCACTG CGCATCCAGC GGTGATCCCG TGGATGTTGT CTGCAGGCCC AAG03GCTGC GCTGCA.GGCC CGGCTGGACC CTGGATTTGG GGTATTCACT CGCGACCACT TGGGGTGCCG ATCGGGAGGC ACTGCTGTCC GCGCCGGGGG TGATAACGGG CTCTGCGAAT TCCGGTGGCC GGTCA.GGGCA GTCAGTGGCT GC3GGATGGGA GCGGACGCCT TG3AGGAAGC CTGCXSACGCG CTAAGCGCAC GGTGTGCTGT TCGGTGCTGA TGAGCAGATG CTCGACCGGA. ATCTTCX3CGG TTCAAGTCGG CCTCCTGGGA GCX3GTGCTGG GGCACTCGGT CGGCX3AG1TG TTGCCGGACX3 CTGCACXSGTT GGTTGCGGCT CX3GGCCCACC GGCGGCGCAA TGCTCGCGGT CGCCACCAGC GAGGCGGCGG GTGTGCGATC GGGTCAGCAT CGCTGCGhTC AACGGCCCCG GACCX3CGATG TGCTCX3TGGA GCTCGCAGGC GAATTCGATG TGGTTCCGGG TCTCCCATGC TITCCACTCG CACCGGATGG GCGGAAACCG CCAGGTGCX3T CGAGTTCGGT GAACCX3GTGG ACCX3GTGCGC TGGACACCAC CX3GACTGATG TGCGCGGCCX3 CX3TGATCCTG TCOSCTTCGG AGACX3GTGTC ATCGTCGAGT TCGGCCCGGA TCCX3ACCAGG CTGGGAGGGT GGCGGCX3ATC CCX3CTGATGC GAGACCGCX3G TGGCX3GCCCT GGCX3CACX3TG CACGTCCGCG
ATATGGCGTT CTCGTCA.GCG GCACCGGGTG GGAATGGTCA CGAATGGCCT
GACTGCGCCG
CGAATGCGGG
GGGGGTCATC
CGTTGCACGT TCACCX3GGAA TCGGGATCAG AGATCGACCA
TGGACGAACG CGCTCGCCGA GCATCX3GA1T
ACCTGGGCGC
ACGCGGCTGG
TGATGCAGGC TCGGACCGCT AGTCGGTAGT CCCGAGGGCT AACCGATTCT TGCCGATCGT ACTACTGGAC
GGACAAGCCC CACGCCCTGG CGGCACCAAC ATCGGATCGG TCTCGCAGCG CX3CTTCTCCG CGCCGTCX3TG TGGCCGGACGCXJETTTTTCC CCCGGCGTTC GGACGTTCGG GCAGTCGGGG GCGGCCGGCC TGTGTTGTCC ATTGCCCACC
TAGGACCAAA GGACX3AGTAC CTCCX3CCGCG GCGCCAAGTG CGTGGACACG
GCAGGGACCG GTGGTGCGGT
CGATGAGGTC GGACTGGTCG 55540 55600 55660 55720 55780 55840 55900 55960 56020 56080 56140 56200 56260 56320 56380 56440 56500 56560 56620 56680 56740 56800 56860 56920 56980 57040 57100 57160 57220 57280 57340 57400 57460 57520 (請先聞讀背面之注意事項再填寫本頁) 、?τ 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（）
GCTTGCTTCG CCGGGACCGG CGCCCGCACC CAGCGGTACT GGCTGGCCGG GCAAGCGGAC GTCGACGCGC GCTTCTGGGA GTTGGTCGAG CTCTGCATCG ACCGGGACCA GCCCTTCCX3G GAGAAACAAC GCCAGGAGGC CCTCGCGGAT GTCGAGGTGC CGTCCGCAGC CGCCCTCCGG GTGCCCCGAG ATCAACCX3GC GGTCGTCATC GCGGTCCTGG AATTGACCGA GCAGGACCTC GCCGTCATTG CGGACCGCAC CGAGGTGACX3 ATGCCCTGCG CGGCGCATCC GCACCTGTCC GCX3ATGCGGG TGTTTCCGCC CCGAGGACGG TCCGGCCGAT AGGGTCGTCG GCCTTGAACA TCCX3CAGTGG CTGGACX3AGA CGTCCCGGAA CX3GG1TGGTG CAGCTCGCCG TGCX5TTCATC CX3GGTTGTTC CCCCGGTCAG AGACATGGCG TAGCCGGGGA CTCX3GTGCCG AGGTCGCACX3 ATGGCTGGCC AGTCGCCGCG GCCCGGAAGC TCCCGGCGCA GGCGTGAAAG TCACAGTCTT GGCCTGCGAT CTGGCGGCCG TTCCCACGGA GTATCCGCTG ACGCCTGCGA ACCTGGCCX3A GACGACCTTG GTCGTCGGCG CGGCGAACCT GGACCGGCTG CTGTTCTCCT CGATCTCGGG AGTTTGGGGA AATGCGTATC TCGATGCCCT TGCCGAGCGC ATCX3CCTGGG GTCCX3TGGGC GGGTGCGGGC CTCCGCCGAA GGGGCCTGGT ACCX3ATGGAA GCCCTGTCCC AACGAGAAAC CX3CCA.TCACC GCCTCTTTCA CCGCGGCCCX3 CCCX3CGACCA GACACCGAGA CCGAGGAGAA GCACGGTGCC CCX3CCCGCTG AGCGCGGACA CCIOCIOCTG CTGGGGCACG ATTCX3GCX3GA GGCTGTGCAA GATTCGCTGA CCGCGGTAGA GCTGCGCAAC CCGCCGACGC TGGTTTTCGA CCACCCGACG GCCCTGGTCG CGGAGCCGGA CAACGGCATC
GTCGAGTTGC
CGCGCCGATC
TCCTGGCGCT
CCACCTACGC CTTCCAACGC GCGATGTGGT TGCCGACCCG CGGAACCX5TT GGTGGATGAA CCGTTCTGGC ACCAGGTGCG TGGTGGTGCT
GACGCGCTGA CAACX3CAGTG GGTGTGTTGT CGTGGTGTCG CCGCTGTGGC CCGGACCACG TGGGGTGGCC GCCGCACTCX3 GTTCGCAGAG ACGGTCCTCA
GCGGACCTAG GTGACGGACC TCX3GCGGTCG
GCCGGCX3GCC CGACGGGCTT ATGGCCGTTC CCX3CAGTCGG GTCGCAGATG CTGITGGAAG
CCCGATCGGA. AGGTTGAACG CCGCTGGCGT GAATCGCTGC 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐）
CTCTGTTGGC CCGCTACCGT TGGCCACGAC GCTTGATCTG TGATCGACCT CCGGGACGGC TGGTGCGCGC TCACGGGCX3G CTGAGCACCT GGGCCX3AGCT GCGACGAGCT TGCACACCX3C CCGACGTGTT AACCGTTGGA AAGGAGCCTA GCGGGCGGCC AGGAAGGTAA CCCTCTTCX3C TGGACTGGGA AGATCGTGGA
TGGCGGAAAC CCTTCGCCGA CGGTGACCGG TGTCCGAACA TCGCCGAGCT
GATGGACGGC GATCCTGACG
TCCGGAGACA GGCCGAAGAT AGCGCGGAAC AACAGGCGCG GGTGTTGATC GACTGAACTC GGG3GCGGTG CGGCGTCGGG GTCX3GCCAAG CX3CCTTCGTG TTCGGCCGCC GGCGACX3TGC CGAGGCGCAT GCTGCAACAG GCGATTCGCC TCTACGGCCC ICGCACTG CGCCAGCACC ACTGGGCTTC GCTTCX3CCTG GTTGGTTCCX3 CGACAGGCTG 57580 57640 57700 57760 57820 57880 57940 58000 58060 58120 58180 58240 58300 58360 58420 58480 58540 58600 58660 58720 58780 58840 58900 58960 59020 59080 59140 59200 59260 59320 59380 59440 59500 59560 (請先閱讀背面之注意事項再填寫本頁)
1237058 at B7 五、發明説明（ 經濟部智慧財產局員工消費合作社印製
GATACCACX3T TGGCGCAAGG GCCTTCX3ATC CCACTGGAAG ACCAGGCCAA GGTGGCGGA.G CGCTTGCACG CACTCCTCGC CAAGTGGGAC GGGGCGCGTG ACGGCACGGC CAGAGCGACG TCACCCCAAT Q3CTGACX3GC GGCCACGGAC GA03AAATCT TCGACCTCAT CX3ACCGGAAG TTCCX3GCGCT GACCGCCCTT TCCTCX3CCTC AGCTCCCCTG ATTACTGGAA CGGTGTATTT CX3ATGGCCAA TGAAGAAAAG CTCCGCGAGT ACCTCAAGCG TGTCGTCOTC G^CTGGAAG AGGCGCACGA ACX3CCTGCAC GAGTTGGAGC GCCAGGAGCA CX3ACCCCATC GCGATCX3TGT CGA.TGGGA.TG TCGTTATCCC GGTGGCGTCT CCACTCCGGA GGAGCTGTGG CX3ACTGGTCG TCmCXSGAGG AGACGCGATC GCGAACTTCC CCX3AAGACCG TGGCTGGAAT CTGGACGAGC TGTTCGATCC TGATCCGGGC CX3AGCCGGGA CCTCCTACX5T CCGCGAGGGT GGTTTCCTGC GCGGGGTCGC GGACTTCGAT GCCGGGCTCT TCGGGATCAG TCCGCGCGAG GCACAGGCGA IX3GACCCX3CA ACAGCGGTTG CTGCTGGAGA TCTCGTGGGA GGTGTTCGAG CX3CGCCGGCA TTGACCCX3TT TTCTTTGCGG GGTACCAAGA CCX3GTGTGTT CGCX3GGCCTG ATCTACCACX? ACTACGCX3TC GCGGTTTCX3C AAGACCCCCG CX^GTTCGA GGGTTACTTC GCCACCGGCA ACGCGGGCAG CGTCGCATCC GGCCGGGTGG CTTACACCTT CGGGTTAGAG GGCCCGGCGG TCACCGTGGA CACCGCCTGC TCX3TCGTCCC TGGTGGCX3CT GCACCTGGCC TGCCA.GTCCC TC03GCTGGG CX3AATGCGAC CIOGCCCTGG CCGGTGGCAT TTCGGTGATG GCCACGCCGG GAGCCTTCGT CGAGTTCAGC CGGCAACGCG CACTCGCCTC GGATGGCCGG TGCAAGCCCT TCGCX3GATGC CGCCGACX3GC ACCGGCTGGG GCX3AGGGCX3C CX3GAATGCTG CIOCTGGAAC GGCTGTCGGA CGCACGACGA AACGGCCACC CGGTGCTGGC GGCGGTGGTC TCAACCAGGA CGGGACGTCC AACGGCCTGA COGCGCCCAG CGGTCCCGCA TGATCCGCCA AGCCCTGGCG AACX3CCGGGT TGTCX3CCCGC CGAGGTCGAT CGCACX3GCAC GGGCACX3GCC TTGGGCX3ACC CX3ATCGAGGC GCAGGCCCTG ATCGCCACCT ACGGGGCGAA CCGGTCGGCG GATCATCCGC TGCTGCTGGG TTCCCTCAAG TCGAACATCG GCCACACCCA GGCTGCCGCC GGTGTGGCCG GGGTGATCAA GTCGGTCCTG GCCATCA.GGC ACCX3GGAGAT GCCCCX3CAGC CIOCACATCG ACCAGCCATC GCAGCACGTG GACTGGTCGG CGGGCGCGGT GCGGCTGCTC ACGGACAGCG TTGACTGGCC GGATCTCGGC AGGCCGCGCC GAGCAGGGGT GTCCTCGTTC GGCATGAGCG GTACCAACGC ACACCTGATC GTCGAGGAAG TATCCXSACGA GCCGGTCTCG GGCAGTACCG AGCCX3A.CCGG GGCATTTCCC TGGCCGCTGT CCGGCAAGAC GGA.GACGGCA TIOCX3CGAGC AGGCTGCCX3A GTTGCTCTCC GTAGTGACCG AGCACCCX3GA. GCCGGGACTG GGGGACGTCG GGTACTCGCT GGCCACCGGT CGCGCTGCX3A. TGGA.GCACCG GGCTGTCX5TG GTTGCCGACX3 ATCX3GGACTC TTIO3TCGCC GGACTGACGG CGTTGGCTGC GGGCGTTCCG GCAGCCAACG TGGTGCAGGG CX3CX3GCCGAC TGCAAGGGAA AGGTCGCGTT CGTGTTCCCC GGCCAGGGCT CGCATTGGCA GGGGATGGCG AGGGZ^ACTGT CCX3AATCCTC GCCGGTGTTC CGGCX3GAAGC TGGCGGAATG CX3CX3GCGGCT ACX3GCCCCTT
59620 59680 59740 59800 59860 59920 59980 60040 60100 60160 60220 60280 60340 60400 60460 60520 60580 60640 60700 60760 60820 60880 60940 61000 61060 61120 61180 61240 61300 61360 61420 61480 61540 61600 (請先閲讀背面之注意事項再填寫本頁) • _ 訂 線 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 1237058 A7 B7 五、發明説明（） 經濟部智慧財產局員工消費合作社印製 ACGTGGACTG GTOSCTGCTC GGOTTCCTTC GCGGTGATCC OSATGCACCC GCX3ACX3ACX3T GATTCAGCTC GCGCTGTTCG CCATGATGGT GTTCGTGCX3G AGTGGAGCCC GCCX3CX3GTGG TOSGTCATTC CCCATGTGGC AGGCGCTTTG TCCTTGACTG ATGCGCTGCG CATCATCGCT ATGCGGTGTC GGOSCTGACC GGGAAGGGAG GCA.TGCTCGC GATTGCCTTC CX3GTGGTGAA GCGAATCGCA GGCCTGCCGG AGCTGA.CCGT TGCGGCGGTC GCTCCACTGT CGTTTCCX3GC GAACCX3TCGG CTCTGGAGCG TCTGCAGACC CGGAAAACGT GCAGACCCGG CGGGTGGGAA TTGATTACGC CTCGCATTCG CGCAGGTCCA GGGCCGGCTT CTGGACCGGC TCX3CTTTCTA CTCGACGGTC ACCX3GCGAGC GGAC!GGACAC CGGCCX3ACTC ACTGGTACCA GAACCTTCGG CAGCCCGTCC GCTTCCAGCA GACCGTCGCC ATCAGGGCTA TCGGTTCTTC GTCGAGGTGA GCCCGCACCC AGGAAACGCT GGAAGCCGCG GACGCGGGCG GGGTGGTGGT AGGGCGGCTC CCGGCX3CTGG CTGACTTCGC TGGCCGAGTG CCAGGTGCX3C TGAATTGGGA ACAGGTATTC CTCAACACCX3 GAGCCCGhCG CGTGCCX3CTG CGTTCCAGCG GCAGCGGTAC TGGTTGGAGT CCGCCGAGTA CGACX3CGGGC CGGTGGGCTT GCTCTCCX3CC GAGCATCCCC TGCTCX3GGGC TGCGGTGACG CGGGCGGGTT CCTGCTGACC GGCAAGCTGT CGGTCAAGAC CCAGCCCTGG ACGTGGTCX3G CX3GGGCGATC CTGCTGCCCG GCAC(33CX3TT CGTGGAAATG CCGCGGACCA GGTCGGGTGC GATCTGATCG AGGAGTTGTC CCTGACGACT TGCCCGCX3AC CGGTGCGGTG CAC3GTGCAGA TCGCGGTTGG CGGTCCGGAC GCCGCTCGGT CCGCGTGCAT TCCTGTCGAG ACGACGCCGT GCCGCAGGAC GCCACGCGAC CX3GCACX3TTG ACCTCCAGCG ATCACCAGGA CGCCX3GCCAG GGATTTGGCC GCCCAACGAT GCTGTCX3CGG TTCOSCTGGA. CAGCTTCTAC CTGAGCGGGG CTTCGATTTC GGCCCGGCGT TCCAGGGGTT GAGACGAGAT CTTCGCCGAG GTCGGCCTGC CCACCX3CACA CCGCGAAGAC TCGGAATCCA CCCTGCTCTG CTGGATGCGG CACTGCAGGC GCTGGGCGCA ATCCX3GACGA GGGATGGCTC CCX3TTCGCGT GGCAAGGTGT GTCCCTCAAA CACTITCCCT TCGGGTGCAC CTCGTTCCGG CGGGCGCGAA TGCGGTGTCG CCGACACGAC TGGCCAAGCC GTGCTCTCCA TCGATTCGCT GGTGCTGCGC ACAAGCAGTT GGCAGCGGCC CX5TGCGATGG AACACXSAGTC CCTGTTCCX3G AGCGAATCTC GCCCGGCGCT GCCAAGCCX3G TCTCCTGGGC AGTGA.TCGGC TCX3CCCGAGC CTGCGGCTCG GC^CTTGGCA CGGAACTCCA CCCCGACCTG CTCACCCX3CC CCCGGACX5TC GTGGTGGTGC GATGCGGTGC GTCTCGCCAG -8 6 *
GCGCTGGATC GAACTGTGGC ATCGCCGCCG GCCCX3CTGCG
AACGGACCCG GAACTGACCG CCGCAGATCG CCTGCTGAGA GACGCCGACT CGGA.TGGCAG
GCCX3GAATCC
GGACTGCCX3G CCGACCTACC GATCTCGGTT CTGGCCGATG TTGGCCGACC CTGATACGCG CCGCTGGTTT GAGGCCGGGC TCGTGGACCT
GGCCO GCO
:CCCGATG !CX3CGCAG
GCCX3GCAGGT GCCGAAGAGG GCGACX3GGCG GTGTTCACGA CAGATTTCGG GTCGACTGGA AATGACGAAC ACCGGGTTGG GACTTGGACG 61660 61720 61780 61840 61900 61960 62020 62080 62140 62200 62260 62320 62380 62440 62500 62560 62620 62680 62740 62800 62860 62920 62980 63040 63100 63160 63220 63280 63340 63400 63460 63520 63580 63640 (請先閱讀背面之注意事項再填寫本頁) 訂 -線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） TTGCTTCCGA GGCACGTGCC GCGACACAAC GCATGCTTGA CCTCATCCAG CGGCGGCGCG ATT03CCX3GA TCTCGCCTGG TGGTTGTGAC GTCTCGTCCG GTCCCGCCXoA GGGTGTTTCC GACCTGGTGC ATGCTGCGTC GTCGGGTTTG GAACCCX3GAC CGATTCGTGT TGGTCX3ATGT GGA.CGGAACC GTGCGTTCCX3 GAGAACCGCA GCTGGCGTTG GCGCGATGTG TTGCCGCCGA GGACAGCCGG CCX3GTGCGGA TGGGA.CGGTG TTGATTTCCJG GCGGTACGGG CCCGGCATTT GGTGGCGGAG CX3CGGTGTCC GCCGCCTGGT GGAGCGCCCC CGGGGTCACC GACCTGGTGG ATGAGTTGGT GGGCCTGGGA AGGTGGCGAG CTGCGATGTC GGGGATCX3GG CCCAGTTGGA C03GCTGCTG CX3GCAGAGTT CCCOCrGCGC GGAGTGGTGC ATGCGGCCX3G GGCACTTGCC TCGAGTCGCT GACACCAGAG CACX3TGGCAA AGGTGTTCGG CCCGAAGGCC GGCACCTGCA/cGAGTTGACT CTTGATCTGG ATCTCTCGTT CTTCGTGCTC TCTCCX3GCGT GGCGGGGGCT GCGGGTCAGG GAAACTACGC GGCGGCGAAC ACGGCCTGGC TCAGCACCGG CX3GACX3GCGG GGCTGCCTGC GGTGTCX3CTG TGTGGGAGCA GCCCAGCGGG ATGACCX3GAG CX3CTCGATGC CGCGCACCAA TCCGCCGATG TCCGCGCCGG ACGGGTTGCG GCGTTCCGGG CGAATCGCTT CTGGTTCCGG TCCACGTCGA ATGCGGCCGA CGGCGGTGTG CCTGCGTTGT TGCGCGACCT GGAGCX3CGGT CAACGAGTCG GCX3GACGTCA ACGGTCTGGT TGGTCX3GCTG CGGA.CCTGGA TCAGGAAACC CAGCTGTTGG GTTTGGTGCG CX3AGCATGTT TGGGGCATTC GGGTGCGGTC GAGGTCGGGG CCGATCGTGC TTTCCGGGAT ATTCX5TTGTC CGGTGTGGAG TTTCGGAACC 03GCTACTGC GGTGTTCGAC TATC03A.CAC AACTGATTGG TGGCGTGGAG GCTCCGACTC CCGCACCGGC CTGA.CGA.TCC OTTTGTGATC GTGGGGATGG GCTGTCGTTA TCCX3GGTGGG CGGAGGAGCT TTGGCX5TTTG GTGGCCGGGG GCITOGATGC GGTGGCGGAG AT03TGGCTG GGA.TCAGGCG GGGTTGTTCG ATCCGGATCC CX3ATCGTCTT ATGTGTGTGA GGGTGGCTTC CTGCGAGATG CGGCAGAGTT CGATGCOGGT TTTCCCCGCG TG^GGCGTTG GCGATGGATC GGGAAACCGT GGAGCGGGCX3 GGGATTGATC GCTGATGCA.C CACGACTACG GCGCX3CX3GTT CATCACGAGG TTATCTAGGT AA.TGGCAGCG ATTCGTTTGG TTTCGAGGGT CCTGCGGTGA CGGTGGA.TAC -8 7 ~
GATTGGTTGG GCGTCGACAG TTGCX5TTCGG GCCGAATCAT CGCGCCGGTG ATCCCA.GTGC GGGTTGGTTG CGACGCGGCT
ACGACGATCT GACX3GGGTCG GCCGGTGCGT TTCTCCTCGT GCGTTCCTGG
AGCCGCATTG ATGGCGTTTC
TTGGGTTTTG GTTCGGTTGC TTGCTCGACA GCX3GTGACTG GTGTCCTCGC TTCCCGGACG GGGA.CCTCGT
CGGACCGGCG
GCGCCGGAGG 63700 63760 63820 63880 63940 64000 64060 64120 64180 64240 64300 64360 64420 64480 64540 64600 64660 64720 64780 64840 64900 64960 65020 65080 65140 65200 65260 65320 65380 65440 65500 65560 65620 65680 (請先閱讀背面之注意事項再填寫本頁) ^^1. 訂 -線 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（） TGGCGCTGCA CCTGGCGGGT CAAGCACTGC GGTCTGGTGA GTGTGA.TCTG GCTCTTGCGG 65740 GTGGTGTGAC GGTGATGGCC ACGCCGGGGA TGTTCX3TGGA GTTTTCGCGT CAACGGGGCT 65800 TGGCGGCGGA TGGGCX3GTGC AAGTCGTTTG OXXX3GCTGC GGATGGCACC GGTTGGGGAG 65860 AAGGCX3CGGG CTTGGTGTTG TTGGAGCGGC TGTCGGATGC CCX3GCGCAAC GGGCACGCGG 65920 TTCTGGCGGT CX5TGCGGGGT AGCGCGGTGA ATCAGGATGG TGCGTCGAAT GGTTTGACGG 65980 CGCCGAATGG GCCCTCX3CAG CAGCGGGTGA TC^CXSCAGGC GTTGGCGA.GT GCTGGTTTGT 66040 OSGTGTCTGA TGTGGACX3CC GTGGAGGCGC ATGGGACTGG AACCAGGCTT GGTGATCCX3A 66100 TTGAGGCGCA GGCTCTGATT GCCACTTACX3 GGCAGGGGCX3 GGATAGCGAT CX3GCCGTTGT 66160 GG1TGGGGTC GGTGAAGTCX3 AATATTGGTC ATACGCAGGC GGCGGCGGGT GTCGCTGGTG 66220 TGATCAAGAT GGTGATGGCG ATGCX3GCACG GGCAGCTGCC CX3CX3ACGTTG CATGTGGATG 66280 AACCTACX5TC GGAAGTGGAT TGGTCGGCGG GGGATGTCCA GCTCCTCACG GAGAACACCC 66340 CCTGGCCCGG CAACAGCCAT CCTCGGCGGG TGGGCGTGTC GTCGTTCGGG ATCA.GCGGCA 66400 CCAACGCACA CGTCATCCTC GAACAAGCCT CGAAAACACC AGACX3AGACT GCGGAGAAGA 66460 GCGGTCCCGA TTCGGAATCG ACCGTGGACC TTCCAGCGGT CCCGTTGATC GTGTCGGGGA 66520 GAACACCGGC AGCGCTCAGC GCTCAGGCGA GCGCATTGTT GTCCTATITG GGTGAGCGTG 66580 GCGATATITC CACGCTGGAT GCGGCGTTTT CGTTGGCTTC CTCCCGGGCC GCGTTGGAGG 66640 AGCGGGCX3GT GGTGCTGGGA GCGGACCGCX3 AAACGTTGTT GTCCGGGTTG GAAGCX3CTGG 66700 CTTCCGGTCX3 CGAGGCTTCT GGGGTGGTGT CX3GGATCCCC GGTCTCTGGC GGGGTTGGGT 66760 TCGTGTTCGC CGGTCAGGGC GGA.CAGTGGT TGGGGATGGG CCX3GGGGCTC TACTCGGTTT 66820 TTCCGGTGTT 03CTGACGCX5 TTTGACGAAG CA.TGTGCCGG ACTGGACX3CG CATCTGGGGC 66880 AGGACGTGGG GGTCCX3GGA.T GTGGTGTTTG GTTCCX3ACX3G GTCCTTGTTG GATCX3GACGC 66940 TGTGGGCCCA GTOSGGTTTG TT03CGTTGC AGGTTGGTTr GCTGAGCCTG CT3GGTTCGT 67000 GGGGTGTCCG GCCX3GGTGTG GTGCTGGGCC ATTCGGTCX3G CX^GTTCGCG GCGGCGGTTG 67060 CGGCGGGAGT GTTGTCX5TTG CCX3GATGCX3G CTCX3GATGGT GGCX3GGTCGT GCCCGGTTGA 67120 TGCAGGCGTT GCCTTCTGGC GGTGCCATGT TGGCX3GTGGC TGCTGGTGAG GAGCAGCTGC 67180 GGCCGTTGTT GGCCGATCGG GTTGATGGTG CGGGTATCX3C CGCGGTCAAC GCTCCTGAGT 67240 CX3GTGGTGCT CTCCGGCX3AT CGGGAGGTGC TTGACX3ACAT CX3CCX3GCX3CG CTGGATGGGC 67300 AAGGGATTCG GTGGCGGCGG TTGCGGGTTT OSCATGCGTT TXMTCGTAT CGGATGGACC 67360 CGA.TGTTGCA GGAGTTCGCC GAAATCGCAC GCAGCGTGGA CTACCGGCGT GGCGACCTAC 67420 CX3GTCGTGTC GACX3TTGACX3 GGTGAGCTCG ACACCGCAGG TGTGATGGCT ACX3CCGGAGT 67480 ATTGGGTGCG TCAGGTTCGA GAGCCCGTCC GCTTCGCCGA CGGCGTCCGG GTGCTCGCGC 67540 AGCAAGGGGT CGCCACGATC TTCGAACTCG GCCCTGATGC GACGCTGTCG GCCCTGATTC 67600 CCGATTGTCA TTCGTGGGCT GATCAGGCCA TGCCXSAITCC GATGCTGCGT AAAGACCGTA 67660 CGGAAACCGA AACTGTGGTC GCCX3CGGTGG CGCX3GGCX3CA CACXXX3TGGT GTTCCX3GTCG 67720 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先聞讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
AATGGTCGGC GTATTTCGCC GGCACCGGGG CACGGCGGGT CGAGTTCCCX3 TCCAGCGGCA GCGGTACTGG CTGGAAACAT CGGA.TTACX3G CGATGTGA.CG TGGCTGCGGC GGAGCATCCG TTCCTGGGGG CCX3TGGTTGC GCTGGCCX3AT TGGTGCTGAC CXSGCCXSGTTG TCGGTGGGGA CGCATCCX3TG GCTGGCCCAG TGGGCGA.GGT CGTCGTCCCC GGCACCGCCA TCCTGGAGAT GGCCCTGCAC GTCTCGGCTG TGACCGGGTG GAAGAGCTCA CCCTGGAAAC ACCX3CTGGTG GCGCGGCGGG TGCCX3GTAGT CGTGGCCCTG CGGGAGGGAC (^C^GTTTCA CGGAAGAACX5 TGTGCGGACX3 AACGACGCCA TCGAAATCCA GCIOCTGGTG ACGAAGGCGG TCGGCGAAGG GTGTCGCTGT ATTCCCGCCC GGCCGGTGGG GGGGTTGGAC GCGCCACX3CC ACCGGCGAAC TO3TCGTCGG CACCACCX3GT TTCCTGA.TTG GTCX3GCTGAG GGTGCCGAGT CX^TTGCTCT CGA.TGAGTTC TGGCCGGAAA CGGGTTCGAG TACGGGCCGT TGTTCCAGGG GCTTCAGGCG GTGGTGACX3A GGTTCTCGCC GAAATCGCCC CGCCX3GCCX3A GGCCX3A.TGCJG GATACCTGCT CGACCCAGCG TTGCTGGATG COXX3CTGCA GCCCGGAGCA AGGCX3GCGCG TGGCTGCCGT TCH^TTCAC CGGCAGGGAC GATCAGCAGG GTGCGGCTGG AGACCAGGCG ACCCGACGCG CCX3TGATGGA TGAGAGTGGG CX3GTTGCTCX3 CCIO3ATCGA TTCTCTCAGG TGTCGTCGGG ACAGCTGGCG AATCGGGACG CTGTCCGCGA CGCGCTGTTC GGGAGCCX3GT GGCGACGCAG TCGACGGAAC 03GGTO3CTG GGCCCTGCTT CCTGCGGTAA AGACGATCTC ATCAAACTCG CAA03GATTC CX3CCX3ACCX3C TGGCGGCGCT AGCCGAGAAA CTTGATTCCA GCGCGCTGGT TCCTGATGTC GCGCCGGAGA ACAGGCGGAT CCCX3GCACCG GCGCAGCCGC ACTTGCGGAG COTTGGCTCT GCTCCAAGCX3 TGGTTGGCTG AGCCGCX3GTT GGCCX3A.GGCA TGGTGACX3TG TX3CAGCGGTG ACX3ACX3GCTC CGAGTGACGG TGCATCAGAG CX3CCX5TTGTG GGGGTTGTTG CGTGCCX3CGC AGGTGGAGAA CCCX3GGGCAG CGGACGTCGA CX3GAACCX3CC GAATCGTGGC GTGCGTTGCC GAGTGCGTTG AACCGCAGTT GGCCCTGCX3G AAGGGCGCGG TGCGAGCGCC CCXXrCTGGCT GGCAGATCX3A. CGTGCCCGCX3 GTTGTGGCGG ATCCCGACCG AACCGTGCTG GCACGGGCCT GTTGGGGGGC GCGGTTGCCC GCCACCTGGT GACCX3AACX3C GAITGGTGTT GACGGGCCGT CX3TGGCTGGG ATGCTCCTGG AATCACCX3AG AGCTGAACGG CCTCGGTGCC GTGGTCGACG TGGTGGCGTG CGACGTCGCG ATCTGGAGTC GTTGCTGGCG GCGGTCCCGG COGAATTTCC G1TGTGCGGC CCGCGGGGGC GCTGGCCGAC GGGGTGATCX3 AGTCGTTGTC ACC!GGACGAC TGTTCGGCCC GAAGGCGGCG GGGGCGTGGA ATCTGCACGA GCCX^CTCGT
ACGTATGCCT GGTATCGGCC GGTGA.TGGGA CATCGCGTGC
GTCCCCGAAC ATTGAAACTG AACGCACCCG TCGAGAGGTG GGTAGGGCX3G TACGTCGCTC GCATGGCGTC ATGGCGTCGG
CTCGGCGACC
ATATCX3GTGG CTACGAAGCX3 GAGGTGACCT GGTGATACTG TGCGCGGATC GTGGTCTACT ACCCAGCAGA CGTCTGGTGG CTGGCACATG TTTGTGCTGG GGCTCGATGG TCGGTCGCCG ATTTCGGGCG GGTGTCCGCC TTGGTGGGTG GATCGTGCTG GTGGTGCATG GTGGGA.GCGG GATACGGACC 67780 67840 67900 67960 68020 68080 68140 68200 68260 68320 68380 68440 68500 68560 68620 68680 68740 68800 68860 68920 68980 69040 69100 69160 69220 69280 69340 69400 69460 69520 69580 69640 69700 69760 (請先聞讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 A7B7 經濟部智慧財產局員工消費合作社印製
五、發明説明（） TGTCGTTCTT CGCGTTGTTC TCCTCGCTTT ATTATGCX3GC GGCGAACX3CG TTCCTGGACG TGCCTGCGGT GTCGCTGGCC TGGGGCCTGT TCAGCGAGGT CX3ACCGGAGC AGGATCGCX3C GATTGCGGCT GTTO3ATGCC GGGCTGGCX3C TGGACAGGAC TTTCCTGGCC GAGCAGGCGC CACTGGTACC CCCCATCCGT CGTAATAGGC GCACCCTGCT CX3GGGTGGTG COGGAGCATG CTGACGTCGG GGTCGAGCGC GCTTTCCGGG AGTTGCGGAA CCGCCITGCC GGGGTGCTGG ACTATCCGAC GCCGAGGGCG CTGGCCCGGT CTACGACGCC AGCGCCGGTG ACGACGACCA CGATAGTCGG GATGGGATGC CGTTTTCCCG GTTTGGTGGC CGGGGGCGTG GATGCGGTCG TGGCAGGCTT GTTCGATCCG GACCCGGAAC CCTTCCTCAC CGACGCCGAT CGGTTCGATG CGTTGGCGAT GGATCCGCAG CAACGGCTGT GGGCAGGGAT CGATCCGGGT TCX3CTGAGGG TGTACCACGA CTATGGCGCC CGGTTCGCCA. TCX3GCAATGG CAGTGCTGGG AGTGTCX3CGT AGGGTCCTGC GGTGACGGTG GATACTGCGT CGGGTCA.GTC GTTGCGTTCC GGCX3AATGCG TGTCGACGCC CGGGACGTTT GTGGAATTCT GGTGCAAGTC GTTCGCGGAG AGCX3CGGACG TGTTGTTGGA GCX3GTTGTCX3 GATGCTCGGC GTGGGTCGGC GGTGAATCA.G GATGGTGCX3T CGCAGCAGCG GGTCATCCAG CAGGCX3TTGG ATGCCGTGGA GGCX3CA.TGGG ACCGGGACCA TGATTGCTAC GTATGGGCX3C GA.TCGTGATC AGTCCAACAT CGGTCATACG CAGGCGGCGG TGGCGA.TGCG GCACGGGCAA CTTCCX3CX3CA TGGATTGGTC GGCGGGGAGG GTCCAGCTCC GTCGCCCCTG TCGGGTGGGG GTGTCGTCX3T TCCTGGAACA GTCCACGGGG CAGATGGATC CCX3GTGTTGC CGGCGCTCCT GGTCAGGGCA 69820 CATTGGCX3CA TTACCX3GCGG TCACAGGGAC 69880 GGGA.GCA.GCC GAGCGGGATG ACGGAGACGC 69940 GCX3CCAACCC GCCGTTGTCC ACCAAGGA.GG 70000 TGGACCGGGC AGCGGTAGTT CCGGCGAAGT 70060 GGTCGGGCTC GCTGCCCXSCA TTGTTGACGG 70120 GGGCTAGCX3G AACCX3AGCTC GCX3GACGAGG 70180 CCGCGGCCGT GCTGGGGTAT TCGAGCGCGG 70240 ATCTGGGTTT TX^TTCGTTG TCTGGTGTGG 70300 GGGTGCX3GTT GCCGGCX3A.CT GCX3GTGTTCG 70360 TCCTGCACCA GGAACTGGCA GACX3AGATCG 70420 GGGCACCGGT CGCCGAAGAC GATCTCGTCG 70480 GTCAGGTGTC CTCGCCGGAG GMCTCTGGC 70540 CGGACTTCCC AGCCGATCGC GGCTGGGATC 70600 GGGCTGGGAA GACCTACX5TG CGGGAAGGGG 70660 CGGGlTrCTT CGGGATTTCC CCGCGTGAGG 70720 TGCTGGAGCT GTCCTGGGAG GCCA.TTGAAC 70780 GGAGTCGGAC CGGTGTGTTC GCGGGGCTGA 70840 GCCX3A.GCCCC GGAAGGTITC GAGGGGTATC 70900 CGGGCCGGAT TGCGTACTCG TTTGGTTTCG 70960 GTTCGTCGTC GTTGGTGGCG TTGCATTTGG 71020 ATCTCGCCCT TGCCGGTGGT GTGACX3GTGA 71080 CC03TCAGCX3 GGGCCTGGCA CCX3GACGGGC 71140 GTACCX3G1TG GGGTGAGGGT GCTGGTTTGG 71200 GGAATGGGCA TCGGGTGTTG GCGGTGGTTC 71260 CGAATGGCIT GACCGCGCCG AATGGTCCCT 71320 CGAGTGCX3GG TCTGTCGGTG TCCX3ATGTGG 71380 GGTTGGGTGA TCCGATTGAG GCGCAGGCTC 71440 CCGGTCX3GCC GTTGTGGTTG GGGTCGGTGA 71500 CGGGTGTTGC CGGTGTGATC AAGATGGTGA 71560 OSCTGCACGT GGATGCACCC TCCTCGCAGG 71620 TGkCGGAGAA CACGCCCTGG CCCGACAGTG 71680 TCGGGATCAG CGGCACCAAC GCGCACGTCA 71740 AGGCAGCGGA GCCGGATTCG AGTCCTGTTC 71800 -90 - (請先閲讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（） 經濟部智慧財產局員工消費合作社印製
TGGATGTTCC GGTGGTGCCG TGGGTGGTGT CGGGCAAAAC ACCCGAAGCG CTATCCGCCC AGGCGGCAAC GTTGGCGA.CC TATTTGGACC AAAATGTTGA. TGTCTCCCCT CIOGACXjTTG GGATTTCGCT TGCGGTGACC CGTTCGGCGC TGGATGAGCG GGCGGTGGTG ATCOTGACAC GTTGTTGTCT GGCCTGAATG CGCT3GCTGC CGGTCATGAG TGGTTACX3GG ACCTGTCX3GG ATTGGTGGCC GGACCX3GGTT GTCAGTGGTT GGGGATGGGC CX3CCX3GTTGT ACTCGGAGTT TCGACXSAAGC ATGCGCCX3AG CTCX3ATGCGA ACCTGGGGAG GGAAGTCGGG GTTCGGGATG TGGTGTTCGG CTCCGACGAG TCCTTGCTGG ATCGGACTTT GTGGGCGCAG TCGGGTTTGT TCX3CGTTGCA GGTCGGTCTC TGGGAATTGT TGGGTACX3TG GGGTGTTCGG CCCAGCGTAG TTCGGTCGGG GAGCTAGCCG OSGOTTTCGC CGCAGGTGTG CTOTO3ATGG CGCGGTTGAT GCAGGCGTTG CCTTCTGGCG GTGCCATGCT GGCGGTGTCC GCX3ACCGAGG CCCX3AGTCGG CCCXXTOCTC GATGGGGTGC GGGATCGTGT TX3GTGTCGCA GCX3GTTAACG CTCCX3GGGTC GGTGGTGCTT TCCX3GTGACC GGGATGTGCT CGATGGCATT GCCGGTCGGC TGGACX3GGCA AGGTATCCX3G TCGAGGTGGT TGCGGGTTTC GCACGCGTTT CATTCGCATC GGATGGATCC GATGCTGGCG GAGTTCGCCG AGCTCGCACG GAGCGTGGAC TACCGGTCTC CACGGCTGCC GATTGTCTCG ACGCTGACCG GAAACCTCGA TGACGTGGGC GI^TCGCTA CGCCGGAGTA TTGGGTGCGC CAGGTGCGAG AGCCCOTCCG CTTCGCCGAC GGTGTCCAGG CX3CTTGTGGA CO^SGCX3TC GACACGAITG TGGAACTCGG TCCX3GACX3GG GCGTTGTCGA GCITGGTrCA AGAGTGTGTG GCX3GAGTCCG GGCGGGCGAC GGGGATTCCX3 TTGGTGCGGA GAGACCXJTGA TGAGGTCCX3A. A03GTGCTGG ACGCTTTGGC GCAGACCCAC ACTCGTGGTG GCGCGCTGGA CTGGGGGTCA GTACGAGGGC AACXSCAAGTC GACCITCCCA CGTATGCCTT CCAACX3ACAG TGGAGCCATC GGATTCC!GGT GATGTGACCX5 GTGTTGGCCT GACCGGGGCX5 GAGCATCCX3C TGTTGGGTGC CX3TGGTGCCX3 GTCGCGGGCG GCGATGAGGT GCTGCTGACC GGCAGGCTGT CGGTGGGGAC GCATCCGTGG Cia303GAAC ACCGCGTGCT GGGCGAAGTC GTCGTCCCCX3 GCACCGCXSTT GCTGGAGATG GCGTGGCGGG CCX3GTAGCCA GGTCGGTTGT GAACGTGTGG AGGAGCTCAC CTTGGAGGCA CCX3CTGGTCC TGCCGGAGCG GGGCX3CTGCX3 GCGGTGCAGT TGGCGGTGGG GGCTCCX3GAT GAGGCCX3GCC GGCX3CAGTTT GCAGCTCTAT TCCCX3AGGCG CIOATGAAGA 03GCGACTGG OSGCGGATTG CCTCCGGGCT GTTGGCCCAG GCCAATGCGG TGCCGCCGGC GGATTCGACG GCATGGCCGC CX3GACX3GCX3C CGGGCAGGTC GATCTGGCGG AGTTCTACXaA GCX3CCTCGCC GAGCGCGGCT TGACCTACX3G TCCX3GTATTC CAAGGGCTCC GCX3CCX3CA.TG GCGGCACX3GC GACGATATCT TCGCCGAATT GGCCGGGTCA. CCAGACGCCT CGGGTTTCGG CATCCACCCG GCGCTGCTGG ACX3CTGCACT GCAOSCGATG GCGCTTGGTG CTTCX3CCCGA CTCGGAAGCG CGTCTGCCGT TTTCCTGGCXS TGGCGCCCAG CTGTACCGCG
71860 71920 71980 72040 72100 72160 72220 72280 72340 72400 72460 72520 72580 72640 72700 72760 72820 72880 72940 73000 73060 73120 73180 73240 73300 73360 73420 73480 73540 73600 73660 73720 73780 73840 (請先聞讀背面之注意事項再填寫本頁) 辱 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） A7 1237058 B7 五、發明説明（） CTGAAGGAGC AGCGCTTCGG GTACX3GCTCT CGCCGCTQGG CTCCGGTGCA GTCTCATTGA 73900 CGTTGGTGGA TGCCACAGGG CGACGAGTCG CTGCGGTGGA ATCGCTTTCG ACGCX3ACCGG 73960 TCTCCACCGA CCAGATCGGT GCCGGTCGCG GCGATCAAGA GCGGCTGCTG CACGTCGAGT 74020 GGGTAAGGTC GGCTGAATCT GCGGGGATGT CTCTGACCTC CTGCGCGGTG GTCGGTTTGG 74080 GCX3AACCGGA GTGGCACGCT GCX3CTGAAGA CCACTGGTGT CCAAGTCGAG TCCCATGCGG 74140 ACCITCCTTC GTTGGCCACC GAGGTTGCCA AGOSGGGTTC AGCTCCTGGT GCGGTCATCG 74200 TCCCGTGCCC GCGACCCCGA GCGATGCAGG AGCTGCCGAC CGCCGCGCGA AGGGCGACGC 74260 AACAGGCX3AT GGCGATGCTG O^SCAATGGC TTGCCX3ATGA CCGGTTCGTC AGTACGCX3CC 74320 TGATCCTGCT GACGCATCGG GCGGTCTCCG CAGTTGCTGG AGAAGACGTG CTCGACCTGG 74380 TACACGCGCC GCTGTGGGGC TTGGTCCGCA GCGCGCAAGC GGAGCACCCG GACCGATTCG 74440 CCTTGATCGA TATGGACX3AC GAGCX3AGCA.T CX3CAGACX3GC ACTCGCCX3AA GCGCTGACTG 74500 CGGGAGAAGC GCAGCKX3CG GTGCGGTCGG G3VGTTGTGCT GGCGCCCCGC CTCX3GCCAGG 74560 TGAAGGTGAG TGGAGGTGAA GCX3TTCAGGT GGGATGAAGG CACCGTGCTG GTCACCX3GCX3 74620 GAACCGGCGG GCTCGGGGCC CTGCTCGCAC GCC^TCTGGT CAGCX3CCCAC GGTGTGCGGC 74680 ACCTGTTGCT CGCAAGTCGC CGTGGTCTGG CGGCGCCCGG AGCGGATGAG CTGGTGGCCG 74740 AGCTGGAGCA GGCCX3GCGCC GACGTCGCGG TCGTCGCGTG CX3ACTCX3GCA GATCGGGACT 74800 03CTTGCGCG GCTGGTGGCG TCGGTGCCTG CX3GAAAACCC GTTGCGGGTG GTGGTGCACG 74860 CCGCCGGTGT GCTGGATGAC GGTGTGCTGA TGTCGATGTC GCCX3GA.GCX3C TTGGA.CGCGG 74920 TOTTGCC3GCC CAAAGTGGAT GCCX3CGTGGT ACCTGCACGA GCTGACTCGG GAACTCGGTC 74980 TGTCGGCGTT CGTGTTGTTC TCCTCGGTCG CGGGCCTGTT CX3GCGGTGCX? GGGCAGAGCA 75040 ATTACX3CTGC QGGCAACGCT TTCCTGGATG CCTTGGCGCA TTGCCX3GCAG GCCCAGGGGC 75100 TGCCCX3CGCT GTCGCTGGCC TCCGGGCTGT GGGCGAGTAT CX3ATGGAATG GCGGGCGACC 75160 TCGCTGCX3GC AGATGTGGAG 03GCTGTCX3C GGGCAGGCAT TGGCCCGCTT TCGGCACCGG 75220 GAGGGCTGGC CTTGTTCX3AC GCTGCCGTTG GCTCGGACX3A AC03TTGCTG GCACCGGTGC 75280 GACTGGATGT 03AAGCACTG CGTGTGCAGG CCCX3ATCCGT GCAGACCCX3G ATTCCGGAAA 75340 TCCTGCATGG CATGGCAATG GGGCCAAGCC GCCGCACTCC GTTCACTTCC AGGG1TGAGC 75400 CGTTGCACGA ACGGCTGGCC GGMTGTCGG AGGGCGAACG TCGGCAGCAA GTGCTCCAGC 75460 GCX3TCCX3CGC 03ATATCGCG GTGGTACTGG GGCACGGCAG GTCGAGCX3AT GTGGACA.TCG 75520 AGAAGCCTTT GGCCGAGCTG GGTTTCGACT CGCTGACGGC CATCGAACTC CGCAACCGTC 75580 TCGCTACCGC CACCGGACTG CGGCTTCCCG CGACGCTGGC CTTCGACCAC GGCACTGCGG 75640 CGGCACTCGC CCAGCACX5TG TGCGCGCAGC TAGGCACCGC GACCGCGCCG GCACCX3A.GGC 75700 GAACCGACGA CAACGACX3CC ACGGAGCCCG TGAGGTCGCT CTTCCAACAG GCX3TATGCGG 75760 CTGGCCX3GAT ACTTGACGGG ATGGATTTGG TGAAGGTCGC TGCCCAGTTG CX3ACCGGTGT 75820 TCGGTTCGCC TGGCGAGCTG GAATCCCTGC CGAAACCCX3T CCAGCTTTCC CGTGGTCCCG 75880 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
、1T 争· 經濟部智慧財產局員工消費合作社印製 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） AAG^GCTTGC CTTGGTGTGC ATGCCX3GCGC TGATCGGGAT GCCX3CCCGCA CAGCAGTACG 75940 CGCX3GATCGC CGCCX3GGTTC OXX3A.TGTGC GGGA.CGTTTC GGTGATCCCG ATGCCTGGAT 76000 TCA1TGCGGG AGAACCGCTG CCX5TCCGCCA TCGA.GGTGGC GGTTCGGACX3 CAGGCGGAGG 76060 CGGTGCTGCA GGAATTCGCC GGGGGCTCGT TCGTACTGGT CGGGCATTCC TCCGGGGGCT 76120 GGCTGGCGCA CGAGGTAGCC GGTGAGCTGG AGCGTCGCGG GGTCGTCCCG GCCGGGGTCG 76180 TACIOCTGGA CACCTACATC CCCX3GTGAGA TCACGCCGAG GTTCTCCGTG GCGATGGCCC 76240 ACCGGACGTA TGA.GAAGCTC GCGACTETCA CX3GACATGCA GGATGTCGGT ATCACCX3CX3A 76300 TGGGCGGGTA CTTCCX3GATG TTCACCGAGT GGACTCCGAC GCCGATCGGT GCTCCGACGC 76360 TGTTCX3TGCG GACCGAAGAT TGCGTCGCAG ACCCTGAAGG GCXSGCCGIOG ACAGATGACT 76420 CCTGGCGGCC AGGGTC3GACT CTC!GCGGATG CCACGGTCCA GGTGCCGGGC GACCACTTCT 76480 CGATGATGGA CX3AGCACX3CC GGGTCCACCG CACAGGCAGT OSCGAGTTGG CITGA.CAAAC 76540 TCAACCAGCG CACCGCTCX3G CAACX3CTGAC GGGCGTCCTT TTAGGACCTT CTGGGCGGCA 76600 CCGGCCACCC CX3GCGGTGCC GCCTTCCGTG GTCCAGGCTC GCCGATCTTG ACX3GCGCACX5 76660 ATGCGCGGCA CGCGCGCTGA TCGTGATTCC GCTGCCGCTC GTGGCCATCG GCCTGGCGAA 76720 TCATGTCCTT TCX3GGCAACG TCAAACXSAAT TCGTCCX3AGC CCGCATTCC!G AGGTGAGGGG 76780 CACCCTTGGG TGGCTGA.GCC GCTCAAGGGT GCCCCTCACC TCGAAATTCG TCCGATTTGG 76840 GCGGTGGACG CAACCCCGGT GGGCGTGGTG CGTCTITCTT GTTGA.CAGAG CX3GTGAGAAG 76900 CCX3CTGACAC ACCTGAGAGG AAAAGGGGAG CATGATGCTC AAGCX3CCACC GTTTGACX3AC 76960 CGCCATCACC GGCCTTCTGG GGGGAGTACT GCTGGTCAGC GGCTGCGGAA CCGCCGCCGC 77020 ACTTCAGTCC TCGCCGGCGC CCX3GGCATGA C3CX3CX3CAAT GTTGGTATGG CCTCGGGCX3G 77080 GGGCGGCGGG GACATCGGCA CGTCGAACTG CTCGGAGGCC GATTTCCTCG CCACCGCGAC 77140 ACCGGTGAAA GGCGACCCCX3 GCMTTTCAT CGTGGCGTAC GGGAACCX3GT CGGA.CAAGAC 77200 CTGCACGATC AACGGCGGCG TGCCGAACCT CAAGGGCGTG GACATGAGCA ACTCGCCGAT 77260 CGAGGACCTG CCX3GTCX5AGG ACGTGCX3GCT TCCCX3ACGCX3 CCCAAGGAAT TCACCCTCCA 77320 GCCCGGTCAG AGCGCGTACG CCGGCATTGG CATGGTCCTG GCCGACAGCG GCGACCCGAA 77380 CGCCCATGTC CTCACCX3GGT TCCAGTCCTC GCTGCCGGA.C ATGTCCX3AGG CCCAGCCGGT 77440 CAACGTTCTC GGCGACX3GCA ACGTGAAGTT CGCCX3CGAAG TACCTGCGAG TO\GCTCX3CT 77500 GGTGTCTACC GCAGACGAGC TGCGCTAAAA CCCATCTGAG TCCCGCAGAT TCGACCTCGC 77560 CGTCCGGCX3C CTCCX3GCGAA GCGTCCX3TAC GTTTGTCGTT GTGACCAGCX3 TTGTTCACGT 77620 CCX3GGCGCAG CGCTGGTACA TACTCAGGCG TCTCGGGCGC CTCCAACGGG GCCTGGCATC 77680 CX3GGGCCGTC GAGTGCX3GCG GCX3CTGACX3C GTTCTCTGTC GGGCX3TTGTC ACGCCGCCX3G 77740 CCTCXSAACCG GTCCCGCCCC GTCX3GAGCCX3 GTGGTCCAGC GCGGTGTGGC GGCX3GCCX3GA. 77800 GCCGACGGTG CX3CACCGCCT GCCCGAGGGC CTTITTCGAA CCGACGAGGA CCACGACCTT 77860 CTTCGCCCGG GTGACCGCCG TGTAGAGCAG GTTGCGCTGC AGCATCATCC AGGCGCITGT 77920 (請先閱讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
GGTCAAGGGG ATCACCACGC ACX3GGTATTC GCTTCCCTGC G^03ATGGA TCGTCACCGC GTAGGCGTGG ACCAGTTCGT OSAGTTCTGT GAAGTCX3TAG TCGATGTCCT CGTCCTCX3TC
GGTTCGCACG GTCATGGTCT GTCCTTCGTT GTTGAACACG CCX3TTGGCGC CCTTGTCGTA GACGCGGAAG ATCCGTCCGC CGAACCGCCG CX3CITCCTGC AACAGCTGGT G^GGACCTGC ACGTCGGTGC GACGTCGACG
GACACGACGC CCTGCGTGCC ATCTGCGTGA CCTTGTCGCC CCCTCCCTGG CCGC3GGTGA.T GGGCCTCGAT GCATCGGGGC CCGGAACTTC CGCGGAATCC GGCGGGCGAC GCITTCCTCT ACGTGGAACA GGAAGAAGTC GGTCAGCCCG TGTGTCAGCX3 GATAGTCCCC GGCXSITGATT CX3GTGCX3CX3T TGGTCACCAC CCCX3GACTCG GCX3GCCTGCC GGAACA.CCTC GTTGAGCCX3C AC!GTGTGGAA TCX3GGGTGCC AGGGGCGAGC i^TCXSCGCA GTACCTCACC GGCTCCX3ACC GACGGGAGCT GGTCGACGTC GCCGACCAGC AGCAGGTGCG CGCCGGGCGC GATCGCCTTG GCCAGTTTGT TGGCTAACAG CAGGTCX3AGC ATGGACGCCT CX3TCGACCAC GACGAGGTCX3 GCGTCCAGCX3 GGTTGTCCCX3 GTCGTAGGCG GCX3TCCCCGC CCGGGTGGAG TTGGAGCAGG CX3GTGCACGG TCX3CCGCGTC GTGTCCGGTG AGCTCGGTCA GC03CTTCGC CX3CTCGTCCC GTCGGCX3CGG CXSAGGATCAC CTTGGCCTTT TTCGCCTGAG CTAATGCGAT GATCGACCGC ACGGTGAAGC TCTTGCCGCA GCCTGGACCT CCGGTGAGCA CGGCGACCTT CTCGGTCAGG GCCAGCTTGA CX3GCGCGCTC CTGCX3CCTCG G03AGTTCGG CACCX3GTAGC GCX3GCGCAAC CAGTCGAGGG CCITGTGCCA' ATCGACGTCG GCGAAGACGG GCATCCGGTC CGCGCTGGTG TTCAGCAGCC GGGACAGCTG GTTGGCCAGG GCGACTTCX3G CGCX3GTGGAA GGGCACGAGG TAGATCX3CGA C03TCGGCAC CTCGTCGTCA TCGGTGGGGA TCTCCTCGCG GACCACACCT TCCTCGGTGA CX3AGTTC!GGC GAGGCATTCG ATCACCAGCC CGGTGTCGAC GGCGAGGATC TTCACCXSCCT CGGCGATCAG CTCX3TTCTCC GGCAGGTAGC AGTTGCCGTC GCCX3GTGGAC TCCGACAGCG TGAACTGAAG GCCCGCCm ACC03CTGCX3 GGGAGTCGTG CX3GGATTCCC ACCX3CTTTGG CX3ATGGTGTC GGCX3GTCITG AAACCGATTC CCCACACX3TC GCCTGCCAGC O^TATGGCT CTTCCTTGAC GGTCCX3GATC GCX3TCGTCGT GGTACIOCTT GTAGATCTTC ACCGCCAGCX3 AGGTCGAGAC GCCGACGCCT TGCAGGAAGA TCATCACCTC CITGATCGCC TTCTGCTCCT CCCACGCGTC GGCGATCAGC TTCGTCCGCT TCGGGCCGAG CITGGGGACC TCGATCAGCC GCGCGGGTTC CTGCTCGATG ACGTCGAGCG CGGCGACGCC GAAGTGGTCG ACGATCITCT CGGCGAGTTT GGGGCCGATG CCCTTGATCA GGCCAGACCC C^GGTAGCGG CX3GA.TACCTT GCACGGTCGC AGGCAGCACG GTCXjTGTAGT CGTCGACXjTG GAACTGCCGC CCX3TACTGGG GGTGCX3ACCC CCACCGGCCG CGCATGCGCA ACGCCTCX3CC GGGCTGCX3CG CCCA.GCAGCX3 CGCCX3A.CGAC CGTCACCAGG TCACCGCCCC GGCCGGTGTC GATCCGCX3CG ACGGTGTAGC CGCTCTCCTC GTTGGCGAAC GTGATCCGCT CCAGCXjTGCC CTCCAGCACC GCAGTCCACG TGGCCX3ACTC
77980 78040 78100 78160 78220 78280 78340 78400 78460 78520 78580 78640 78700 78760 78820 78880 78940 79000 79060 79120 79180 79240 79300 79360 79420 79480 79540 79600 79660 79720 79780 79840 79900 79960 (請先閲讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
CCGTCCTTTT TCCACCGACA ACACX3TATCA CX3AACX3GCTG TCAAGCAAAC CX3GCGGTCAC 80020 CACATGCAGC GGCATCTCCC GAACGCCTCG GGCTCCX3GCG TCAGCX3GGTG GGCGTTCGCG 80080 ATGCCTTGGT GCGGCCGGTG GGA.GTTGTAG ATTTTITCGT CCTCGCGCAG AGGTGCCGCT GGCTCCAGA.T C ：CTGGAGT 80140 80161 (2)序列辨識號碼:2之資料： (i) 序列特徵： (A) 長度：2595個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:2 Met Ser Glu Ala Gly Asn Leu lie Ala Val lie Gly Leu Ser Cys 15 15 10 Leu Pro Gin Ala Pro Asp Pro Ala Ser Phe Trp i 20 25 Gly Thr Asp Ala lie Thr Thr Val Pro Glu Gly j 35 40 Leu Pro Gly Arg Asp Ala Pro Lys Gly Pro Glu Trp Gly Gly Phe Leu 50 55 60 Ala Asp Val Asp Cys Phe Asp Pro Glu Phe Phe Gly lie Ser Pro Arg 65 70 75 80 Glu Ala Ala Thr Val Asp Pro Gin Gin Arg Leu Ala Leu Glu Leu Ala 85 90 95 Trp Glu Ala Leu Glu Asp Ala Gly lie Pro Ala Gly Glu Leu Arg Gly 100 105 110 Thr Ala Ala Gly Val Phe Met Gly Ala lie Ser Asp Asp Tyr Ala Ala 115 120 125 Leu Leu Arg Glu Ser Pro Pro Glu Val Ala Ala Gin Tyr Arg Leu Thr 130 135 140
Leu Leu Arg Thr 30 Trp Gly Asp Pro 45 (請先閲讀背面之注意事項再填寫本頁) 、?τ -95 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（）
Gly Thr His Arg Ser Leu lie Ala Asn Arg Val Ser Tyr Val Leu Gly 145 150 155 160
Leu Arg Gly Pro Ser Leu Thr Val Asp Ser Gly Gin Ser Ser Ser Leu 165 170 175 .Val Gly Val His Leu Ala Ser Glu Ser Leu Arg Arg Gly Glu Cys Thr 180 185 190 工 le Ala Leu Ala Gly Gly Val Asn Leu Asn Leu Ala Ala Glu Ser Asn 195 200 205
Ser Ala Leu Met Asp Phe Gly Ala Leu Ser Pro Asp Gly Arg Cys Phe 210 215 220
Thr Phe Asp Val Arg Ala Asn Gly Tyr Val Arg Gly Glu Gly Gly Gly 225 230 235 240
Leu Val Val Leu Lys Lys Ala Asp Gin Ala His Ala Asp Gly Asp Arg 245 250 255 工le Tyr Cys Leu lie Arg Gly Ser Ala Val Asn Asn Asp Gly Gly Gly 260 265 270
Ala Gly Leu Thr Val Pro Ala Ala Asp Ala Gin Ala Glu Leu Leu Arg 275 280 285
Gin Ala Tyr Arg Asn Ala Gly Val Asp Pro Ala Ala Val Gin Tyr Val 290 295 300
Glu Leu His Gly Ser Ala Thr Arg Val Gly Asp Pro Val Glu Ala Ala 305 310 315 320
Ala Leu Gly Ala Val Leu Gly Ala Ala Arg Arg Pro Gly Asp Glu Leu 325 330 335
Arg Val Gly Ser Ala Lys Thr Asn Val Gly His Leu Glu Ala Ala Ala 340 345 350
Gly Val Thr Gly Leu Leu Lys Thr Ala Leu Ser lie Trp His Arg Glu 355 360 365
Leu Pro Pro Ser Leu His Phe Thr Ala Pro Asn Pro Glu lie Pro Leu 370 375 380
Asp Glu Leu Asn Leu Arg Val Gin Arg Asp Leu Arg Pro Trp Pro Glu -96 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 -辱 經濟部智慧財產局員工消費合作社印製 1237058 A7 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） 385 390 395 400 Ser Glu Gly Pro Leu Leu Ala Gly Val Ser Ala Phe Gly Met Gly Gly 405 410 415 Thr Asn Cys His Leu Val Leu Ser Gly Thr Ser Arg Val Glu Arg Arg 420 425 Arg Ser Gly Pro Ala Glu Ala Thr Met Pro 1 435 440 Thr Pro Val Ala Leu Arg Ala Gin Ala Ala i 450 455 Asn Thr Ala Gly Gin Ser Pro Leu Asp Val Ala Tyr Ser Leu Ala Thr 465 470 475 480 Thr Arg Ser Ala Leu Pro His Arg Ala Ala Leu Val Ala Asp Asp Glu 485 490 495 Pro Lys Leu Leu Ala Gly Leu Lys Ala Leu Ala Asp Gly Asp Asp Ala 500 505 510 Pro Thr Leu Cys His Gly Ala Thr Ser Gly Glu Arg Ala Ala Val Phe 515 520 525 Val Phe Pro Gly Gin Gly Ser Gin Trp lie Gly Met Gly Arg Gin Leu 530 535 540 Leu Glu Thr Ser Glu Val Phe Ala Ala Ser Met Ser Asp Cys Ala Asp 545 550 555 560 Ala Leu Ala Pro His Leu Asp Trp Ser Leu Leu Asp Val Leu Arg Asn 565 570 575 Ala Ala Gly Ala Ala His Leu Asp His Asp Asp Val Val Gin Pro Ala 580 585 590 Leu Phe Ala lie Met Val Ser Leu Ala Glu Leu Trp Arg Ser Trp Gly 595 600 605 Val Arg Pro Val Ala Val Val Gly His Ser Gin Gly Glu lie Ala Ala 610 615 620 Ala Cys Val Ala Gly Ala Leu Ser Val Arg Asp Ala Ala Arg Val Val 625 630 635 640 430 Val Leu Ser Ala Arg 445 Leu His Thr His Leu 460 (請先閲讀背面之注意事項再填寫本頁) 訂 dw. 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 1237058 A7 B7 五、發明説明（）
Ala Val Arg Ser Arg Leu Leu Thr Ala Leu Ala Gly Ser Gly Ala Met 645 650 655
Ala Ser Leu Gin His Pro Ala Glu Glu Val Arg Gin lie Leu Leu Pro 660 665 670 .Trp Arg Asp Arg lie Gly Val Ala Gly Val Asn Gly Pro Ser Ser Thr 675 680 685
Leu Val Ser Gly Asp Arg Glu Ala Met Ala Glu Leu Leu Ala Glu Cys 690 695 700
Ala Asp Arg Glu Leu Arg Met Arg Arg lie Pro Val Glu Tyr Ala Ser 705 710 715 720
His Ser Pro His lie Glu Val Val Arg Asp Glu Leu Leu Gly Leu Leu 725 730 735
Ala Pro Val Glu Pro Arg Thr Gly Ser lie Pro lie Tyr Ser Thr Thr 740 745 750
Thr Gly Asp Leu Leu Asp Arg Pro Met Asp Ala Asp Tyr Trp Tyr Arg 755 760 765
Asn Leu Arg Gin Pro Val Leu Phe Glu Ala Ala Val Glu Ala Leu Leu 770 775 780
Lys Arg Gly Tyr Asp Ala Phe lie Glu lie Ser Pro His Pro Val Leu 785 790 795 800
Thr Ala Asn lie Gin Glu Thr Ala Val Arg Ala Gly Arg Glu Val Val 805 810 815
Ala Leu Gly Thr Leu Arg Arg Gly Glu Gly Gly Met Arg Gin Ala Leu 820 825 830
Thr Ser Leu Ala Arg Ala His Val His Gly Val Ala Ala Asp Trp His 835 840 845
Ala Val Phe Ala Gly Thr Gly Ala Gin Arg Val Asp Leu Pro Thr Tyr 850 855 860
Ala Phe Gin Arg Gin Arg Tyr Trp Leu Asp Ala Lys Leu Pro Asp Val 865 870 875 880
Ala Met Pro Glu Ser Asp Val Ser Thr Ala Leu Arg Glu Lys Leu Arg 本紙張尺度適用中國國家標準（CNS ) Α4規格（210 X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 885 890 895
Ser Ser Pro Arg Ala Asp Val Asp Ser Thr Thr Leu Thr Met lie Arg 900 905 910
Ala Gin Ala Ala Val Val Leu Gly His Ser Asp Pro Lys Glu Val Asp 915 920 925
Pro Asp Arg Thr Phe Lys Asp Leu Gly Phe Asp Ser Ser Met Val Val 930 935 940
Glu Leu Cys Asp Arg Leu Asn Ala Ala Thr Gly Leu Arg Leu Ala Pro 945 950 955 960
Ser Val Val Phe Asp Cys Pro Thr Pro Asp Lys Leu Ala Arg Gin Val 965 970 975
Arg Thr Leu Leu Leu Gly Glu Pro Ala Pro Met Thr Ser His Arg Pro 980 985 990
Asp Ser Asp Ala Asp Glu Pro lie Ala Val 工le Gly Met Gly Cys Arg 995 1000 1005
Phe Pro Gly Gly Val Ser Ser Pro Glu Glu Leu Trp Gin Leu Va' Ala 1010 1015 1020
Ala Gly Arg Asp Val Val Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp 1025 1030 1035 1040
Leu Glu Arg Ala Gly Thr Ser His Val Arg Ala Gly Gly Phe Leu His 1045 1050 1055
Gly Ala Pro Asp Phe Asp Pro Gly Phe Phe Arg lie Ser Pro Arg Glu 1060 1065 1070
Ala Leu Ala Met Asp Pro Gin Gin Arg Leu Leu Leu Glu lie Ala Trp 1075 1080 1085
Glu Ala Val Glu Arg Gly Gly lie Asn Pro Gin His Leu His Gly Ser 1090 1095 1100
Gin Thr Gly Val Phe Val Gly Ala Thr Ser Leu Asp Tyr Gly Pro Arg 1105 1110 1115 1120
Leu His Glu Ala Ser Glu Glu Ala Ala Gly Tyr Val Leu Thr Gly Ser 1125 1130 1135 -99 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 蠢· 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Thr Thr Ser Val Ala Ser Gly Arg Val Ala Tyr Ser Phe Gly Phe Glu 1140 1145 1150
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 1155 1160 1165
Leu His Leu Ala Cys Gin Ser Leu Arg Ser Gly Glu Cys Asp Leu Ala 1170 1175 1180
Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Gly Met Phe Val Glu 1185 1190 1195 1200
Phe Ser Arg Gin Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe 1205 1210 1215
Ala Glu Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly Leu Val 1220 1225 1230
Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Glu Val Leu 1235 1240 1245
Ala Val Val Arg Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn Gly 1250 1255 1260
Leu Thr Ala Pro Asn Gly Ser Ser Gin Gin Arg Val lie Ala Gin Ala 1265 1270 1275 1280
Leu Ala Ser Ala Gly Leu Ser Val Ser Asp Val Asp Ala Val Glu Ala 1285 1290 1295
His Gly Thr Gly Thr Arg Leu Gly Asp Pro 工le Glu Ala Gin Ala Leu 1300 1305 1310 工 le Ala Thr Tyr Gly Gin Gly Arg Leu Pro Glu Arg Pro Leu Trp Leu 1315 1320 1325
Gly Ser Met Lys Ser Asn lie Gly His Ala Gin Ala Ala Ala Gly lie 1330 1335 1340
Ala Gly Val Met Lys Met Val Met Ala Met Arg His Gly Gin Leu Pro 1345 1350 1355 1360
Arg Thr Leu His Val Asp Glu Pro Thr Ser Gly Val Asp Trp Ser Ala 1365 1370 1375
Gly Thr Val Gin Leu Leu Thr Glu Asn Thr Pro Trp Pro Gly Ser Gly 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） 1380 1385 1390
Arg Val Arg Arg Val Gly Val Ser Ser Phe Gly lie Ser Gly Thr Asn 1395 1400 1405
Ala His Val lie Leu Glu Gin Pro Pro Gly Val Pro Ser Gin Ser Ala 1410 1415 1420
Gly Pro Gly Ser Gly Ser Val Val Asp Val Pro Val Val Pro Trp Met 1425 1430 1435 1440
Val Ser Gly Lys Thr Pro Glu Ala Leu Ser Ala Gin Ala Thr Ala Leu 1445 1450 1455
Met Thr Tyr Leu Asp Glu Arg Pro Asp Val Ser Ser Leu Asp Val Gly 1460 1465 1470
Tyr Ser Leu Ala Leu Thr Arg Ser Ala Leu Asp Glu Arg Ala Val Val 1475 1480 1485
Leu Gly Ser Asp Arg Glu Thr Leu Leu Cys Gly Val Lys Ala Leu Ser 1490 1495 1500
Ala Gly His Glu Ala Ser Gly Leu Val Ttir Gly Ser Val Gly Ala Gly 1505 1510 1515 1520
Gly Arg lie Gly Phe Val Phe Ser Gly Gin Gly Gly Gin Trp Leu Gly 1525 1530 1535
Met Gly Arg Gly Leu Tyr Arg Ala Phe Pro Val Phe Ala Ala Ala Phe 1540 1545 1550
Asp Glu Ala Cys Ala Glu Leu Asp Ala His Leu Gly Gin Glu lie Gly 1555 1560 1565
Val Arg Glu Val Val Ser Gly Ser Asp Ala Gin Leu Leu Asp Arg Thr 1570 1575 1580
Leu Trp Ala Gin Ser Gly Leu Phe Ala Leu Gin Val Gly Leu Leu Lys 1585 1590 1595 1600
Leu Leu Asp Ser Trp Gly Val Arg Pro Ser Val Val Leu Gly His Ser 1605 1610 1615
Val Gly Glu Leu Ala Ala Ala Phe Ala Ala Gly Val Val Ser Leu Ser 1620 1625 1630 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
、1T 經濟部智慧財產局員工消費合作社印t 1237058 A7 B7 五、發明説明（）
Gly Ala Ala Arg Leu Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu 1635 1640 1645
Pro Ser Gly Gly Gly Met Leu Ala Val Pro Ala Gly Glu Glu Leu Leu 1650 1655 1660 .Trp Ser Leu Leu Ala Asp Gin Gly Asp Arg Val Gly lie Ala Ala Val 1665 1670 1675 1680
Asn Ala Ala Gly Ser Val Val Leu Ser Gly Asp Arg Asp Val Leu Asp 1685 1690 1695
Asp Leu Ala Gly Arg Leu Asp Gly Gin Gly lie Arg Ser Arg Trp Leu 1700 1705 1710
Arg Val Ser His Ala Phe His Ser Tyr Arg Met Asp Pro Met Leu Ala 1715 1720 1725
Glu Phe Ala Glu Leu Ala Arg Thr Val Asp Tyr Arg Arg Cys Glu Val 1730 1735 1740
Pro lie Val Ser Thr Leu Thr Gly Asp Leu Asp Asp Ala Gly Arg Met 1745 1750 1755 1760
Ser Gly Pro Asp Tyr Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe 1765 1770 1775
Ala Asp Gly Val Gin Ala Leu Val Glu His Asp Val Ala Thr Val Val 1780 1785 1790
Glu Leu Gly Pro Asp Gly Ala Leu Ser Ala Leu lie Gin Glu Cys Val 1795 1800 1805
Ala Ala Ser Asp His Ala Gly Arg Leu Ser Ala Val Pro Ala Met Arg 1810 1815 1820
Arg Asn Gin Asp Glu Ala Gin Lys Val Met Thr Ala Leu Ala His Val 1825 1830 1835 1840
His Val Arg Gly Gly Ala Val Asp Trp Arg Ser Phe Phe Ala Gly Thr 1845 1850 1855
Arg Ala Lys Gin lie Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin Arg I860 1865 1870
Tyr Trp Leu Asn Ala Leu Arg Glu Ser Ser Ala Gly Asp Met Gly Arg -102 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 秦· 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） 1875 1880 1885
Arg Val Glu Ala Lys Phe Trp Gly Ala Val Glu His Glu Asp Val Glu 1890 1895 1900
Ser Leu Ala Arg Val Leu Gly He Val Asp Asp Gly Ala Ala Val Asp 1905 1910 1915 1920
Ser Leu Arg Ser Ala Leu Pro Val Leu Ala Gly Trp Gin Arg Thr Arg 1925 1930 1935
Thr Thr Glu Ser lie Met Asp Pro Arg Cys Tyr Arg lie Gly Trp Arg 1940 1945 1950
Gin Val Ala Gly Leu Pro Pro Met Gly Thr Val Phe Gly Thr Trp Leu 1955 1960 1965
Val Phe Ala Pro His Gly Trp Ser Ser Glu Pro Glu Val Val Asp Cys 1970 1975 1980
Val Thr Ala Leu Arg Ala Arg Gly Ala Ser Val Val Leu Val Glu Ala 1985 1990 1995 2000
Asp Pro Asp Pro Thr Ser Phe Gly Asp Arg Val Arg Thr Leu Cys Ser 2005 2010 2015
Gly Leu Pro Asp Leu Val Gly Val Leu Ser Met Leu Cys Leu Glu Glu 2020 2025 2030
Ser Val Leu Pro Gly Phe Ser Ala Val Ser Arg Gly Phe Ala Leu Thr 2035 2040 2045
Val Glu Leu Val Arg Val Leu Arg Ala Ala Gly Ala Thr Ala Arg Leu 2050 2055 2060
Trp Leu Leu Thr Cys Gly Gly Val Ser Val Gly Asp Val Pro Val Arg 2065 2070 2075 2080
Pro Ala Gin Ala Leu Ala Trp Gly Leu Gly Arg Val Val Gly Leu Glu 2085 2090 2095
His Pro Asp Trp Trp Gly Gly Leu lie Asp lie Pro Val Leu Phe Asp 2100 2105 2110
Glu Asp Ala Gin Glu Arg Leu Ser lie Val Leu Ala Gly Leu Asp Glu 2115 2120 2125 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 蠢· 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（）
Asp Glu Val Ala lie Arg Pro Asp Gly Met Phe Ala Arg Arg Leu Val 2130 2135 2140
Arg His Thr Val Ser Ala Asp Val Lys Lys Ala Trp Arg Pro Arg Gly 2145 2150 2155 2160
Ser Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Ala His Val Ala 2165 2170 2175
Arg Trp Leu Ala Asp Ala Gly Ala Glu His Val Ala Met Val Ser Arg 2180 2185 2190
Arg Gly Glu Gin Ala Pro Ser Ala Glu Lys Leu Arg Thr Glu Leu Glu 2195 2200 2205
Asp Leu Gly Thr Arg Val Ser lie Val Ser Cys Asp Val Thr Asp Arg 2210 2215 2220
Glu Ala Leu Ala Glu Val Leu Lys Ala Leu Pro Ala Glu Asn Pro Leu 2225 2230 2235 2240
Thr Ala Val Val His Ala Ala Gly Val lie Glu Thr Gly Asp Ala Ala 2245 2250 2255
Ala Met Ser Leu Ala Asp Phe Asp His Val Leu Ser Ala Lys Val Ala 2260 2265 2270
Gly Ala Ala Asn Leu Asp Ala Leu Leu Ala Asp Val Glu Leu Asp Ala 2275 2280 2285
Phe Val Leu Phe Ser Ser Val Ser Gly Val Trp Gly Ala Gly Gly His 2290 2295 2300
Gly Ala Tyr Ala Ala Ala Asn Ala Tyr Leu Asp Ala Leu Ala Glu Gin 2305 2310 2315 2320
Arg Arg Ser Arg Gly Leu Val Ala Thr Ala Val Ala Trp Gly Pro Trp 2325 2330 2335
Ala Gly Glu Gly Met Ala Ser Gly Glu Thr Gly Asp Gin Leu Arg Arg 2340 2345 2350
Tyr Gly Leu Ser Pro Met Ala Pro Gin His Ala lie Ala Gly lie Arg 2355 2360 2365
Gin Ala Val Glu Gin Asp Glu lie Ser Leu Val Val Ala Asp Val Asp 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 S. 經濟部智慧財產局員工消費合作社印製 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五 發明説明（ 2370 2375 2380 Trp Ala Arg Phe Ser Ala Gly Leu Leu Ala Ala Arg Pro Arg Pro Leu 2385 2390 2395 2400 Leu Asn Glu Leu Ala Glu Val Lys Glu Leu Leu Val Asp Ala Gin Pro 2405 2410 2415 Glu Ala Gly Val Leu Ala Asp Ala Ser Leu Glu Trp Arg Gin Arg Leu 2420 2425 2430 Ser Ala Ala Pro Arg Pro Thr Gin Glu Gin Leu lie Leu Glu Leu Val 2435 2440 2445 Arg Gly Glu Thr Ala Leu Val Leu Gly His Pro Gly Ala Ala Ala Val 2455 2460 f Ala Phe Lys Asp Ser Gly Phe Asp Ser Gin Ala Ala 2470 2475 2480 f Val Arg Leu Asn Arg Ala Thr Gly Leu Gin Leu Pro 2450 Ala Ser Glu 2465 Val Glu Leu 2485 Ser Thr lie lie Phe Ser His Pro 2500 2490 2495 Thr Pro Ala Glu Leu Ala Ala Glu 2505 2510
Leu Arg Ala Arg Leu Leu Pro Glu Ser Ala Gly Ala Gly lie Pro Glu 2515 2520 2525 Glu Asp Glu Ala Arg lie Arg Ala Ala Leu Thr Ser lie Pro Phe Pro 2530 2535 2540 Ala Leu Arg Glu Ala Gly Leu Val Ser Pro Leu Leu Ala Leu Ala Gly 2545 2550 2555 2560 His Pro Val Asp Ser Gly lie Ser Ser Asp Asp Ala Ala Ala Thr Ser 2565 2570 2575 工le Asp Ala Met Asp Val Ala Gly Leu Val Glu Ala Ala Leu Gly Glu 2580 2585 2590 Arg Glu Ser 2595(2)序列辨識號碼:3之資料·· 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 1237058 at B7 五、發明説明（） (i) 序列特徵： (A) 長度：2152個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:3
Met Thr Val Thr Thr Ser Tyr Glu Glu Val Val Glu Ala Leu Arg Ala 15 10 15
Ser Leu Lys Glu Asn Glu Arg Leu Arg Arg Gly Arg Asp Arg Phe Ser 20 25 30
Ala Glu Lys Asp Asp Pro 工le Ala lie Val Ala Met Ser Cys Arg Tyr 35 40 45
Pro Gly Gin Val Ser Ser Pro Glu Asp Leu Trp Gin Leu Ala Ala Gly 50 55 60
Gly Val Asp Ala lie Ser Glu Val Pro Gly Asp Arg Gly Trp Asp Leu 65 70 75 80
Asp Gly Val Phe Val Pro Asp Ser Asp Arg Pro Gly Thr Ser Tyr Ala 85 90 95
Cys Ala Gly Gly Phe Leu Gin Gly Val Ser Glu Phe Asp Ala Gly Phe 100 105 110
Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin Arg 115 120 125
Leu Leu Leu Glu Val Ala Trp Glu Val Phe Glu Arg Ala Gly Leu Glu 130 135 140
Gin Arg Ser Thr Arg Gly Ser Arg Val Gly Val Phe Val Gly Thr Asn 145 150 155 160
Gly Gin Asp Tyr Ala Ser Trp Leu Arg Thr Pro Pro Pro Ala Val Ala 165 170 175
Gly His Val Leu Thr Gly Gly Ala Ala Ala Val Leu Ser Gly Arg Val 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先閱讀背面之注意事項再填寫本頁) ,ιτ άφ. 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 180 185 190
Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala 195 200 205
Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gin Ala Leu Arg 210 215 220
Ala Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ser 225 230 235 240
Thr Pro Lys Val Phe Leu Glu Phe Ser Arg Gin Arg Gly Leu Ala Pro 245 250 255
Asp Gly Arg Cys Lys Ser Phe Ala Ala Gly Ala Asp Gly Thr Gly Trp 260 265 270
Gly Glu Gly Ala Gly Leu Leu Leu Leu Glu Arg Leu Ser Asp Ala Arg 275 280 285
Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Val Asn 290 295 300
Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Ser Ser Gin 305 310 315 320
Gin Arg Val lie Thr Gin Ala Leu Ala Ser Ala Gly Leu Ser Val Ser 325 330 335
Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp 340 345 350
Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr Gly Arg Asp Arg Asp 355 360 365
Pro Gly Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly His 370 375 380
Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val Met Ala 385 390 395 400
Met Arg His Gly Gin Leu Pro Arg Thr Leu His Val Glu Ser Pro Ser 405 410 415
Pro Glu Val Asp Trp Ser Ala Gly Thr Val Gin Leu Leu Thr Glu Asn 420 425 430 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 、^τ 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五 、發明説明（） Thr Pro Trp Pro Arg Ser Gly Arg Val Arg Arg Val Gly Val Ser Ser 435 440 445 Phe Gly lie Ser Gly Thr Asn Ala His Val lie Leu Glu Gin Pro Pro 450 455 460 Gly Val Pro Ser Gin Ser Ala Gly Pro Gly Ser Gly Ser Val Val Asp 465 470 475 480 Val Pro Val Val Pro Trp Met Val Ser Gly Lys Thr Pro Glu Ala Leu 485 490 495 Ser Ala Gin Ala Thr Ala Leu Met Thr Tyr Leu Asp Glu Arg Pro Asp 500 505 510 Val Ser Ser Leu Asp Val Gly Tyr Ser Leu Ala Leu Thr Arg Ser Ala 515 520 525 Leu Asp Glu Arg Ala Val Val Leu Gly Ser Asp Arg Glu Thr Leu Leu 530 535 540 Cys Gly Val Lys Ala Leu Ser Ala Gly His Glu Ala Ser Gly Leu Val 545 550 555 560 Thr Gly Ser Val Gly Ala Gly Gly Arg lie Gly Phe Val Phe Ser Gly 565 570 575 Gin Gly Gly Gin Trp Leu Gly Met Gly Arg Gly Leu Tyr Arg Ala Phe 580 585 590 Pro Val Phe Ala Ala Ala Phe Asp Glu Ala Cys Ala Glu Leu Asp Ala 595 600 605 His Leu Gly Gin Glu lie Gly Val Arg Glu Val Val Ser Gly Ser Asp 610 615 620 Ala Gin Leu Leu Asp Arg Thr Leu Trp Ala Gin Ser Gly Leu Phe Ala 625 630 635 640 Leu Gin Val Gly Leu Leu Lys Leu Leu Asp Ser Trp Gly Val Arg Pro 645 650 655 Ser Val Val Leu Gly His Ser Val Gly Glu Leu Ala Ala Ala Phe Ala 660 665 670 Ala Gly Val Val Ser Leu Ser Gly Ala Ala Arg Leu Val Ala Gly Arg -108 - (請先閲讀背面之注意事項再填寫本頁) 訂 秦· 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 Λ7 Β7 五、發明説明（） 675 680 685
Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Gly Met Leu Ala Val 690 695 700
Pro Ala Gly Glu Glu Leu Leu Trp Ser Leu Leu Ala Asp Gin Gly Asp .705 710 715 720
Arg Val Gly lie Ala Ala Val Asn Ala Ala Gly Ser Val Val Leu Ser 725 730 735
Gly Asp Arg Asp Val Leu Asp Asp Leu Ala Gly Arg Leu Asp Gly Gin 740 745 750
Gly lie Arg Ser Arg Trp Leu Arg Val Ser His Ala Phe His Ser Tyr 755 . 760 765
Arg Met Asp Pro Met Leu Ala Glu Phe Ala Glu Leu Ala Arg Thr Val 770 775 780
Asp Tyr Arg Arg Cys Glu Val Pro lie Val Ser Thr Leu Thr Gly Asp 785 790 795 800
Leu Asp Asp Ala Gly Arg Met Ser Gly Pro Asp Tyr Trp Val Arg Gin 805 810 815
Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Gin Ala Leu Val Glu 820 825 830
His Asp Val Ala Thr Val Val Glu Leu Gly Pro Asp Gly Ala Leu Ser 835 840 845
Ala Leu lie Gin Glu Cys Val Ala Ala Ser Asp His Ala Gly Arg Leu 850 855 860
Ser Ala Val Pro Ala Met Arg Arg Asn Gin Asp Glu Ala Gin Lys Val 865 870 875 880
Met Thr Ala Leu Ala His Val His Val Arg Gly Gly Ala Val Asp Trp 885 890 895
Arg Ser Phe Phe Ala Gly Thr Gly Ala Lys Gin lie Glu Leu Pro Thr 900 905 910
Tyr Ala Phe Gin Arg Gin Arg Tyr Trp Leu Val Pro Ser Asp Ser Gly 915 920 925 -109 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（）
Asp Val Thr Gly Ala Gly Leu Ala Gly Ala Glu His Pro Leu Leu Gly 930 935 940
Ala Val Val Pro Val Ala Gly Gly Asp Glu Val Leu Leu Thr Gly Arg 945 950 955 960 lie Ser Val Arg Thr His Pro Trp Leu Ala Glu His Arg Val Leu Gly 965 970 975
Glu Val lie Val Ala Gly Thr Ala Leu Leu Glu lie Ala Leu His Ala 980 985 990
Gly Glu Arg Leu Gly Cys Glu Arg Val Glu Glu Leu Thr Leu Glu Ala 995 1000 1005
Pro Leu Val Leu Pro Glu Arg Gly Ala lie Gin Val Gin Leu Arg Val 1010 1015 1020
Gly Ala Pro Glu Asn Ser Gly Arg Arg Pro Met Ala Leu Tyr Ser Arg 1025 1030 1035 1040
Pro Glu Gly Ala Ala Glu His Asp Trp Thr Arg His Ala Thr Gly Arg 1045 1050 1055
Leu Ala Pro Gly Arg Gly Glu Ala Ala Gly Asp Leu Ala Asp Trp Pro 1060 1065 1070
Ala Pro Gly Ala Leu Pro Val Asp Leu Asp Glu Phe Tyr Arg Asp Leu 1075 1080 1085
Ala Glu Leu Gly Leu Glu Tyr Gly Pro lie Phe Gin Gly Leu Lys Ala 1090 1095 1100
Ala Trp Arg Gin Gly Asp Glu Val Tyr Ala Glu Ala Ala Leu Pro Gly 1105 1110 1115 1120
Thr Glu Asp Ser Gly Phe Gly Val His Pro Ala Leu Leu Asp Ala Ala 1125 1130 1135
Leu His Ala Thr Ala Val Arg Asp Met Asp Asp Ala Arg Leu Pro Phe 1140 1145 1150
Gin Trp Glu Gly Val Ser Leu His Ala Lys Ala Ala Pro Ala Leu Arg 1155 1160 1165
Val Arg Val Val Pro Ala Gly Asp Asp Ala Lys Ser Leu Leu Val Cys 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先閲讀背面之注意事項再填寫本頁) 、τ 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） 1170 1175 1180
Asp Gly Thr Gly Arg Pro Val lie Ser Val Asp Arg Leu Val Leu Arg 1185 1190 1195 1200
Ser Ala Ala Ala Arg Arg Thr Gly Ala Arg Arg Gin Ala His Gin Ala 1205 1210 1215
Arg Leu Tyr Arg Leu Ser Trp Pro Thr Val Gin Leu Pro Thr Ser Ala 1220 1225 1230
Gin Pro Pro Ser Cys Val Leu Leu Gly Thr Ser Glu Val Ser Ala Asp 1235 1240 1245 工le Gin Val Tyr Pro Asp Leu Arg Ser Leu Thr Ala Ala Leu Αόρ Ala 1250 1255 1260
Gly Ala Glu Pro Pro Gly Val Val lie Ala Pro Thr Pro Pro Gly Gly 1265 1270 1275 1280
Gly Arg Thr Ala Asp Val Arg Glu Thr Thr Arg His Ala Leu Asp Leu 1285 1290 1295
Val Gin Gly Trp Leu Ser Asp Gin Arg Leu Asn Glu Ser Arg Leu Leu 1300 1305 1310
Leu Val Thr Gin Gly Ala Val Ala Val Glu Pro Gly Glu Pro Val Thr 1315 1320 1325
Asp Leu Ala Gin Ala Ala Leu Trp Gly Leu Leu Arg Ser Thr Gin Thr 1330 1335 1340
Glu His Pro Asp Arg Phe Val Leu Val Asp Val Pro Glu Pro Ala Gin 1345 1350 1355 1360
Leu Leu Pro Ala Leu Pro Gly Val Leu Ala Cys Gly Glu Pro Gin Leu 1365 1370 1375
Ala Leu Arg Arg Gly Gly Ala His Ala Pro Arg Leu Ala Gly Leu Gly 1380 1385 1390
Ser Asp Asp Val Leu Pro Val Pro Asp Gly Thr Gly Trp Arg Leu Glu 1395 1400 1405
Ala Thr Arg Pro Gly Ser Leu Asp Gly Leu Ala Leu Val Asp Glu Pro 1410 1415 1420 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（）
Thr Ala Thr Ala Pro Leu Gly Asp Gly Glu Val Arg lie Ala Met Arg 1425 1430 1435 1440
Ala Ala Gly Val Asn Phe Arg Asp Ala Leu lie Ala Leu Gly Met Tyr 1445 1450 1455 • Pro Gly Val Ala Ser Leu Gly Ser Glu Gly Ala Gly Val Val Val Glu 1460 1465 1470
Thr Gly Pro Gly Val Thr Gly Leu Ala Pro Gly Asp Arg Val Met Gly 1475 1480 1485
Met lie Pro Lys Ala Phe Gly Pro Leu Ala Val Ala Asp His Arg Met 1490 1495 1500
Val Thr Arg lie Pro Ala Gly Trp Ser Phe Ala Arg Ala Ala Ser Val 1505 1510 1515 1520
Pro lie Val Phe Leu Thr Ala Tyr Tyr Ala Leu Val Asp Leu Ala Gly 1525 1530 1535
Leu Arg Pro Gly Glu Ser Leu Leu Val His Ser Ala Ala Gly Gly Val 1540 1545 1550
Gly Met Ala Ala lie Gin Leu Ala Arg His Leu Gly Ala Glu Val Tyr 1555 1560 1565
Ala Thr Ala Ser Glu Asp Lys Trp Gin Ala Val Glu Leu Ser Arg Glu 1570 1575 1580
His Leu Ala Ser Ser Arg Thr Cys Asp Phe Glu Gin Gin Phe Leu Gly 1585 1590 1595 1600
Ala Thr Gly Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Ala Gly 1605 1610 1615
Glu Phe Ala Asp Ala Ser Leu Arg Met Leu Pro Arg Gly Gly Arg Phe 1620 1625 1630
Leu Glu Leu Gly Lys Thr Asp Val Arg Asp Pro Val Glu Val Ala Asp 1635 1640 1645
Ala His Pro Gly Val Ser Tyr Gin Ala Phe Asp Thr Val Glu Ala Gly 1650 1655 1660
Pro Gin Arg lie Gly Glu Met Leu His Glu Leu Val Glu Leu Phe Glu 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁)
1237058 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） 1665 1670 1675 1680 Gly Arg Val Leu Glu Pro Leu Pro Val Thr Ala Trp Asp Val Arg Gin 1685 1690 1695 Ala Pro Glu Ala Leu Arg His Leu Ser Gin Ala Arg His Val Gly Lys 1700 1705 1710 Leu Val Leu Thr Met Pro Pro Val Trp Asp Ala Ala Gly Thr Val Leu 1715 1720 1725 Val Thr Gly Gly Thr Gly Ala Leu Gly Ala Glu Val Ala Arg His Leu 1730 1735 1740 Val lie Glu Arg Gly Val Arg Asn Leu Val Leu Val Ser Arg Arg Gly 1745 1750 1755 1760 Pro Ala Ala Ser Gly Ala Ala Glu Leu Val Ala Gin Leu Thr Ala Tyr 1765 1770 Gly Ala Glu Val Ser Leu Gin Ala Cys Asp Val Ala 1780 1785 Leu Ala Lys Val Leu Ala Ser lie Pro P. 1795 1800 Val Val His Ala Ala Gly Val Leu Asp P. 1810 1815 Thr Val Glu Arg Leu Asp Gin Val Leu Ά 1825 1830 Arg Asn Leu Leu Glu Leu lie Asp Pro Asp Val Ala Leu Val Leu Phe 1845 1850 1855 Ser Ser Val Ser Gly Val Leu Gly Ser Gly Gly Gin Gly Asn Tyr Ala I860 1865 1870 Ala Ala Asn Ser Phe Leu Asp Ala Leu Ala Gin Gin Arg Gin Ser Arg 1875 1880 1885 Gly Leu Pro Thr Arg Ser Leu Ala Trp Gly Pro Trp Ala Glu His Gly 1890 1895 1900 Met Ala Ser Thr Leu Arg Glu Ala Glu Gin Asp Arg Leu Ala Arg Ser 1905 1910 1915 1920 1775 ? Arg Glu Thr 1790 Glu His Pro Leu Thr Ala 1805 Gly Val Ser Glu Ser Leu 1820 Pro Lys Val Asp Gly Ala 1835 1840 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 秦· 1237058 A7 B7 五、發明説明（）
Gly Leu Leu Pro 工le Ser Thr Glu Glu Gly Leu Ser Gin Phe Asp Ala 1925 1930 1935
Ala Cys Gly Gly Ala His Thr Val Val Ala Pro Val Arg Phe Ser Arg 1940 1945 1950 .Leu Ser Asp Gly Asn Ala lie Lys Phe Ser Val Leu Gin Gly Leu Val 1955 1960 1965
Gly Pro His Arg Val Asn Lys Ala Ala Thr Ala Asp Asp Ala Glu Ser 1970 1975 1980
Leu Arg Lys Arg Leu Gly Arg Leu Pro Asp Ala Glu Gin His Arg lie 1985 1990 1995 2000
Leu Leu Asp Leu Val Arg Met His Val Ala Ala Val Leu Gly Phe Ala 2005 2010 2015
Gly Ser Gin Glu lie Thr Ala Asp Gly Thr Phe Lys Val Leu Gly Phe 2020 2025 2030
Asp Ser Leu Thr Val Val Glu Leu Arg Asn Arg lie Asn Gly Ala Thr 2035 2040 2045
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asn Tyr Pro Thr Pro Asp 2050 2055 2060
Ala Leu Ala Ala His Leu Val Thr Ala Leu Ser Ala Asp Arg Leu Ala 2065 2070 2075 2080
Gly Thr Phe Glu Glu Leu Asp Arg Trp Ala Ala Asn Leu Pro Thr Leu 2085 2090 2095
Ala Arg Asp Glu Ala Thr Arg Ala Gin lie Thr Thr Arg Leu Gin Ala 2100 2105 2110 工le Leu Gin Ser Leu Ala Asp Val Ser Gly Gly Thr Gly Gly Gly Ser 2115 2120 2125
Val Pro Asp Arg Leu Arg Ser Ala Thr Asp Asp Glu Leu Phe Gin Leu 2130 2135 2140
Leu Asp Asn Asp Leu Glu Leu Pro 2145 2150 -114 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） (2)序列辨識號碼:4之資料： (i) 序列特徵： (A) 長度：3170個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:4
Met Ser Asn Glu Glu Lys Leu Arg Glu Tyr Leu Arg Arg Ala Leu Val 1 5 10 15
Asp Leu His Gin Ala Arg Glu Arg Leu His Glu Ala Glu Ser Gly Glu 20 25 30
Arg Glu Pro lie Ala lie Val Ala Met Gly Cys Arg Tyr Pro Gly Gly 35 40 45
Val Gin Asp Pro Glu Gly Leu Trp Lys Leu Val Ala Ser Gly Gly Asp 50 55 60
Ala lie Gly Glu Phe Pro Ala Asp Arg Gly Trp His Leu Asp Glu Leu 65 70 75 80
Tyr Asp Pro Asp Pro Asp Gin Pro Gly Thr Cys Tyr Thr Arg His Gly 85 90 95
Gly Phe Leu His Asp Ala Gly Glu Phe Asp Ala Gly Phe Phe Asp lie 100 105 110
Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin Arg Leu Leu Leu 115 120 125
Glu lie Ser Trp Glu Thr Val Glu Ser Ala Gly Met Asp Pro Arg Ser 130 135 140
Leu Arg Gly Ser Arg Thr Gly Val Phe Ala Gly Leu Met Tyr Glu Gly 145 150 155 160
Tyr Asp Thr Gly Ala His Arg Ala Gly Glu Gly Val Glu Gly Tyr Leu 165 170 175 -115 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X：297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 秦· 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（）
Gly Thr Gly Asn Ala Gly Ser Val Ala Ser Gly Arg Val Ala Tyr Ala 180 185 190
Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser 195 200 205
Ser Leu Val Ala Leu His Leu Ala Cys Gin Ser Leu Arg Gin Gly Glu 210 215 220
Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ser Thr Pro Glu 225 230 235 240
Arg Phe Val Glu Phe Ser Arg Gin Arg Gly Leu Ala Pro Asp Gly Arg 245 250 255
Cys Lys Ser Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Gly Glu Gly 260 265 270
Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly 275 280 285
His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gin Asp Gly 290 295 300
Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Leu Ala Gin Glu Arg Val 305 310 315 320 工le Gin Gin Val Leu Thr Ser Ala Gly Leu Ser Ala Ser Asp Val Asp 325 330 335
Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro He Glu 340 345 350
Ala Gin Ala Leu lie Ala Ala Tyr Gly Gin Asp Arg Asp Arg Asp Arg 355 360 365
Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly His Thr Gin Ala 370 375 380
Ala Ala Gly Val Ala Gly Val lie Lys Met Val Met Ala Met Arg His 385 390 395 400
Gly Glu Leu Pro Arg Thr Leu His Val Asp Glu Pro Asn Ser His Val 405 410 415
Asp Trp Ser Ala Gly Ala Val Arg Leu Leu Thr Glu Asn lie Arg Trp 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 蠢. 經濟部智慧財產局員工消費合作社印製 五 I 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 、發明説明（） 420 425 430
Pro Gly Thr Gly Thr Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser 435 440 445
Gly Thr Asn Ala His Val lie Leu Glu His Asp Pro Leu Ala Val Thr 450 455 460
Glu Asn Glu Glu Ala Ala Gin Ser Pro Ala Pro Gly He Val Pro Trp 465 470 475 480
Ala Leu Ser Gly Arg Ser Ser Thr Ala Leu Arg Ala Gin Ala Glu Arg 485 490 495
Leu Arg Glu Leu Cys Glu Gin Thr Asp Pro Asp Pro Val Asp Val Gly 500 505 510
Phe Ser Leu Ala Ala Thr Arg Thr Ala Τ2φ Glu His Arg Ala Val Val 515 520 525
Leu Gly Arg Asp Ser Ala Thr Leu Arg Ser Gly Leu Gly Val Val Ala 530 535 540
Ser Gly Glu Pro Ala Val Asp Val Val Glu Gly Ser Val Leu Asp Gly 545 550 555 560
Glu Val Val Phe Val Phe Pro Gly Gin Gly Trp Gin Trp Ala Gly Met 565 570 575
Ala Val Asp Leu Leu Asp Ala Ser Pro Thr Phe Ala Arg His Met Asp 580 585 590
Glu Cys Ala Thr Ala Leu Arg Arg Tyr Val Asp Trp Ser Leu Val Asp 595 600 605
Val Leu Arg Gly Ala Glu Asn Ser Pro Pro Leu Asp Arg Val Asp Val 610 615 620
Leu Gin Pro Ala Ser Phe Ala Val Met Val Ser Leu Ala Glu Val Trp 625 630 635 640
Arg Ser Tyr Gly Val Arg Pro Ala Ala Val Val Gly His Ser Gin Gly 645 650 655
Glu lie Ala Ala Ala Cys Ala Ala Gly Val Leu Pro Leu Glu Asp Ala 660 665 670 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 1237058 A7 B7 五、發明説明（）
Ala Arg Leu Val Ala Leu Arg Ser Arg Ala Leu Lys Gly Leu Ser Gly 675 680 685
Arg Gly Gly Met Ala Ser Leu Ala Cys Pro Ala Asp Glu Val Ala Ala 690 695 700 .Leu Phe Ala Gly Ser Gly Gly Arg Leu Glu Val Ala Ala He Asn Gly 705 710 715 720
Pro Arg Ser Val Val Val Ser Gly Asp Leu Glu Ala Val Asp Glu Leu 725 730 735
Leu Ala Glu Cys Ala Glu Lys Asp Met Arg Ala Arg Arg lie Pro Val 740 745 750
Asp Tyr Ala Ser His Ser Ala His Val Glu Val Val Arg Ser Pro Val 755 760 765
Leu Ala Ala Ala Ala Gly Val Arg His Arg Asp Gly Gin Val Pro Trp 770 775 780
Trp Ser Thr Val lie Gly Asp Trp Val Asp Pro Ala Arg Leu Asp Gly 785 790 795 . 800
Glu Tyr Trp Tyr Arg Asn Leu Arg Gin Pro Val Arg Phe Glu His Ala 805 810 815
Val Gin Gly Leu Val Glu Arg Gly Phe Gly Leu Phe lie Glu Met Ser 820 825 830
Ala His Pro Val Leu Thr Thr Ala Val Glu Glu Thr Gly Ala Glu Ser 835 840 845
Glu Thr Ala Val Ala Ala Val Gly Thr Leu Arg Arg Asp Ser Gly Gly 850 855 860
Leu Arg Arg Leu Leu His Ser Leu Ala Glu Ala Tyr Val Arg Gly Ala 865 870 875 880
Thr Val Asp Trp Ala Val Ala Phe Gly Gly Ala Gly Arg Arg Leu Asp 885 890 895
Leu Pro Thr Tyr Pro Phe Gin Arg Gin Arg Tyr Trp Leu Asp Lys Gly 900 905 910
Ala Ala Ser Asp Glu Ala Arg Ala Val Ser Asp Pro Ala Ala Gly Trp 本紙張尺度適用中國國家標準（CNS ) A4規格（210X29?公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 秦· 經濟部智慧財產局員工消費合作社印製 五 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 、發明説明（） 915 920 925
Phe Trp Gin Ala Val Ala Arg Gin Asp Leu Lys Ser Val Ser Asp Ala 930 935 940
Leu Asp Leu Asp Ala Asp Ala Pro Leu Ser Ala Thr Leu Pro Ala Leu 945 950 955 960
Ser Val Trp His Arg Gin Glu Arg Glu Arg Val Leu Ala Asp Gly Trp 965 970 975
Arg Tyr Arg Val Asp Trp Val Arg Val Ala Pro Gin Pro Val Arg Arg 980 985 990
Thr Arg Glu Thr Trp Leu Leu Val Val Pro Pro Gly Gly lie Glu Glu 995 1000 1005
Ala Leu Val Glu Arg Leu Thr Asp Ala Leu Asn Thr Arg Gly lie Ser 1010 1015 1020
Thr Leu Arg Leu Asp Val Pro Pro Ala Ala Thr Ser Gly Glu Leu Ala 1025 1030 1035 1040
Thr Glu Leu Arg Ala Ala Ala Asp Gly Asp Pro Val Lys Ala lie Leu 1045 1050 1055
Ser Leu Thr Ala Leu Asp Glu Arg Pro His Pro Glu Cys Lys Asp Val 1060 1065 1070
Pro Ser Gly lie Ala Leu Leu Leu Asn Leu Val Lys Ala Leu Gly Glu 1075 1080 1085
Ala Asp Leu Arg lie Pro Leu Trp Thr lie Thr Arg Gly Ala Val Lys 1090 1095 1100
Ala Gly Pro Ala Asp Arg Leu Leu Arg Pro Met Gin Ala Gin Ala Trp 1105 1110 1115 1120
Gly Leu Gly Arg Val Ala Ala Leu Glu His Pro Glu Arg Trp Gly Gly 1125 1130 1135
Leu lie Asp Leu Pro Asp Ser Leu Asp Gly Asp Val Leu Thr Arg Leu 1140 1145 1150
Gly Glu Ala Leu Thr Asn Gly Leu Ala Glu Asp Gin Leu Ala lie Arg 1155 1160 1165 -119 本紙張又度適用中國國家標準（CNS ) Α4規格（210 Χ297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 1237058 A7 B7 五、發明説明（）
Gin Ser Gly Val Leu Ala Arg Arg Leu Val Pro Ala Pro Ala Asn Gin 1170 1175 1180
Pro Ala Gly Arg Lys Trp Arg Pro Arg Gly Ser Ala Leu He Thr Gly 1185 1190 1195 1200
Gly Leu Gly Ala Val Gly Ala Gin Val Ala Arg Trp Leu Ala Glu lie 1205 1210 1215
Gly Ala Glu Arg lie Val Leu Thr Ser Arg Arg Gly Asn Gin Ala Ala 1220 1225 1230
Gly Ala Ala Glu Leu Glu Ala Glu Leu Arg Ala Leu Gly Ala Gin Val 1235 1240 1245
Ser lie Val Ala Cys Asp Val Thr Asp Arg Ala Glu Met Ser Ala Leu 1250 1255 1260
Leu Ala Glu Phe Asp Val Thr Ala Val Phe His Ala Ala Gly Val Gly 1265 1270 1275 1280
Arg Leu Leu Pro Leu Ala Glu Thr Asp Gin Asn Gly Leu Ala Glu lie 1285 1290 1295
Cys Ala Ala Lys Val Arg Gly Ala Gin Val Leu Asp Glu Leu Cys Asp 1300 1305 1310
Ser Thr Asp Leu Asp Ala Phe Val Leu Phe Ser Ser Gly Ala Gly Val 1315 1320 1325
Trp Gly Gly Gly Gly Gin Gly Ala Tyr Gly Ala Ala Asn Ala Phe Leu 1330 1335 1340
Asp Thr Leu Ala Glu Gin Arg Arg Ala Arg Gly Leu Pro Ala Thr Ser 1345 1350 1355 1360 工 le Ser Trp Gly Ser Trp Ala Gly Gly Gly Met Ala Asp Gly Ala Ala 1365 1370 1375
Gly Glu His Leu Arg Arg Arg Gly lie Arg Pro Met Pro Ala Ala Ser 1380 1385 1390
Ala lie Leu Ala Leu Gin Glu Val Leu Asp Gin Asp Glu Thr Cys Val 1395 1400 1405
Ser lie Ala Asp Val Asp Trp Asp Arg Phe Val Pro Thr Phe Ala Ala -120 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 秦· 經濟部智慧財產局員工消費合作社印製 i___I_ 經濟部智慧財產局員工消費合作社印製 1490 Met Ala Val 1505 Leu Pro Thr 1237058 at B7 發明説明（） 1410 1415 1420
Thr Arg Ala Thr Arg Leu Phe Asp Glu Val Pro Ala Ala Arg Lys Ala 1425 1430 1435 1440
Met Pro Ala Asn Gly Pro Ala Glu Pro Gly Gly Ser Pro Phe Ala Arg 1445 1450 1455
Asn Leu Ala Glu Leu Pro Glu Ala Gin Arg Arg His Glu Leu Val Asp 1460 1465 1470
Leu Val Cys Ala Gin Val Ala Thr Val Leu Gly His Gly Ser Arg Glu 1475 1480 1485
Glu Val Gin Pro Glu Arg Ala Phe Arg Ala Leu Gly Phe Asp Ser Leu 1495 1500 )Leu Arg Asn Arg Leu Thr Thr Ala Thr Gly Leu Arg 1510 1515 1520 f Thr Yal Phe Tyr Pro Asn Pro Ala Ala Ala 1525 1530 1535
Ala His Leu Leu Glu Glu Leu Val Gly Asp Val Ala Ser Ala Ala Val 1540 1545 1550
Thr Ala Ala Ser Ala Pro Ala Ser Asp Glu Pro lie Ala lie Val Ala 1555 1560 1565
Met Ser Cys Arg Phe Pro Gly Gly Ala His Ser Pro Glu Asp Leu Trp 1570 1575 1580
Arg Leu Val Ala Ala Gly Thr Glu Val lie Gly Glu Phe Pro Ser Asp 1585 1590 1595 1600
Arg Gly Trp Asp Ala Glu Gly Leu Tyr Asp Pro Asp Ala Ser Arg Pro 1605 1610 1615
Gly Thr Thr Tyr Ala Arg Met Ala Gly Phe Leu Tyr Asp Ala Gly Glu 1620 1625 1630
Phe Asp Ala Asp Leu Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met 1635 1640 1645
Asp Pro Gin Gin Arg Leu Val Leu Glu lie Ala Trp Glu Ala Leu Glu 1650 1655 1660 本紙張又度適用中國國家標準（CNS ) A4規格（210Χ297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 1237058 A7 B7 五、發明説明（）
Arg Ala Gly lie Asp Pro Leu Ser Leu Lys Gly Ser Gly Val Gly Thr 1665 1670 1675 1680
Tyr lie Gly Ala Gly Ser Arg Gly Tyr Ala Thr Asp Val Arg Gin Phe 1685 1690 1695 .Pro Glu Glu Ala Glu Gly Tyr Leu Leu Thr Gly Thr Ser Ala Ser Val 1700 1705 1710
Leu Ser Gly Arg Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val 1715 1720 1725
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 1730 1735 1740
Cys Gin Ser Leu Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly 1745 1750 1755 1760
Val Thr Val Met Ser Thr Pro Glu Met Phe Val Glu Phe Ser Arg Gin 1765 1770 1775
Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ala Glu Ser Ala 1780 1785 1790
Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Leu Leu Leu Leu Glu Arg 1795 1800 1805
Leu Ser Asp Ala His Arg Asn Gly His Arg Val Leu Ala Val Val Arg 1810 1815 1820
Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn Gly Leu Ala Ala Pro 1825 1830 1835 1840
Asn Gly Pro Ser Gin Gin Arg Val lie Asn Gin Ala Leu Ala Asn Ala 1845 1850 1855
Ala Leu Ser Ala Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly 1860 1865 1870
Thr Arg Leu Gly Asp Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr 1875 1880 1885
Gly Gin Ala Arg Glu Arg Asp Arg Pro Leu Trp Leu Gly Ser Val Lys 1890 1895 1900
Ser Asn lie Gly His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie -122 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 1905 1910 1915 1920
Lys Met Val Met Ala Met Arg His Gly Gin Leu Pro Ala Ser Leu His 1925 1930 1935
Ala Asp Glu Pro Thr Ser Glu Val Asp Trp Ser Ser Gly Ala Val Arg 1940 1945 1950
Leu Leu Ala Glu Gin Val Pro Trp Pro Glu Ser Asp Arg Val Arg Arg 1955 1960 1965
Val Gly Val Ser Ser Phe Gly lie Ser Gly Thr Asn Ala His Val lie 1970 1975 1980
Leu Glu Gin Ala Thr Asn Ala Pro Asp Ser Thr Ala Glu Thr Asp Lys 1985 1990 1995 2000
Thr Glu Ser Gly Ser Thr Val Asp lie Pro Val Val Pro Trp Leu Val 2005 2010 2015
Ser Gly Lys Thr Thr Asp Ser Leu Arg Gly Gin Ala Glu Arg Val Leu 2020 2025 2030
Ser Gin Val Glu Ser Arg Pro Glu Gin Arg Ser Leu Asp Val Ala Tyr 2035 2040 2045
Ser Leu Ala Ser Gly Arg Ala Ala Leu Asp Glu Arg Ala Val Val Leu 2050 2055 2060
Gly Ala Asp Arg Gly Glu Leu Val Ala Gly Leu Ala Ala Leu Ala Ala 2065 2070 2075 2080
Gly Gin Glu Ala Ser Gly Val lie Ser Gly Thr Arg Ala Ser Ala Arg 2085 2090 2095
Phe Gly Phe Val Phe Ser Gly Gin Gly Gly Gin Trp Leu Gly Met Gly 2100 2105 2110
Arg Ala Leu Tyr Ser Lys Phe Pro Val Phe Ala Ala Ala Phe Asp Glu 2115 2120 2125
Ala Cys Ala Glu Leu Glu Ala His Leu Gly Glu Asp Arg Arg Val Arg 2130 2135 2140
Asp Val Val Phe Gly Ser Asp Ala Gin Leu Leu Asp Gin Thr Leu Trp 2145 2150 2155 2160 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 蠢· 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Ala Gin Ser Gly Leu Phe Ala Leu Gin Ala Gly Leu Leu Gly Leu Leu 2165 2170 2175
Gly Ser Trp Gly Val Arg Pro Asp Val Val Met Gly His Ser Val Gly 2180 2185 2190
Glu Leu Ala Ala Ala Phe Ala Ala Gly Val Leu Ser Leu Arg Asp Ala 2195 2200 2205
Ala Arg Leu Val Ala Ala Arg Ala Arg Leu Met Gin Ala Leu Pro Ser 2210 2215 2220
Asp Gly Ala Met Leu Ala Val Ala Ala Gly Glu Asp Leu Val Arg Pro 2225 2230 2235 2240
Leu Leu Ala Gly Arg Glu Glu Ser Val Ser Val Ala Ala Leu Asn Ala 2245 2250 2255
Pro Gly Ser Val Val Leu Ser Gly Asp Arg Glu Val Leu Ala Ser lie 2260 2265 2270
Val Gly Arg Leu Thr Glu Leu Arg Val Arg Thr Arg Arg Leu Arg Val 2275 2280 2285
Ser His Ala Phe His Ser His Arg Met Asp Pro Met Leu Gly Glu Phe 2290 2295 2300
Ala Gin lie Ala Glu Ser Ala Glu Phe Gly Lys Pro Thr Thr Pro Leu 2305 2310 2315 2320
Val Ser Thr Leu Thr Gly Glu Leu Asp Arg Ala Ala Glu Met Ser Thr 2325 2330 2335
Pro Gly Tyr Trp Val Arg Gin Ala Arg Glu Pro Val Arg Phe Ala Asp 2340 2345 2350
Gly Val Gin Ala Leu Ala Ala Gin Gly lie Gly Thr Val Val Glu Leu 2355 2360 2365
Gly Pro Asp Gly Thr Leu Ala Ala Leu Val Arg Glu Cys Ala Thr Glu 2370 2375 2380
Ser Asp Arg Val Gly Arg lie Ser Ser lie Pro Leu Met Arg Arg Glu 2385 2390 2395 2400
Arg Asp Glu Thr Arg Ser Val Met Thr Ala Leu Ala His Leu His Thr 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 2405 2410 2415
Arg Gly Gly Glu Val Asp Trp Gin Ala Phe Phe Ala Gly Thr Gly Ala 2420 2425 2430
Arg Gin Leu Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin His Tyr Trp 2435 2440 2445 lie Glu Ser Ser Ala Arg Pro Ala Arg Asp Arg Ala Asp lie Gly Glu 2450 2455 2460
Val Ala Glu Gin Phe Trp Thr Ala Val Asp Gin Gly Asp Leu Ala Thr 2465 2470 2475 2480
Leu Val Ala Ala Leu Asp Leu Gly Ala Asp Asp Asp Thr Cys Ala Ser 2485 2490 2495
Leu Ser Asp Val Leu Pro Ala Leu Ser Ser Trp Arg Ser Gly Leu Arg 2500 2505 2510
Asn Arg Ser Leu Val Asp Ser Cys Arg Tyr Arg lie Ser Trp His Ser 2515 2520 2525
Ser Arg Glu Val Pro Ala Pro Lys lie Ser Gly Thr Trp Leu Leu Val 2530 2535 2540
Val Pro Gly Ala Ala Asp Asp Gly Leu Val Thr Ala Leu Thr Ser Ser 2545 2550 2555 2560
Leu Val Gly Gly Gly Ala Glu Val Val Arg lie Gly Leu Ser Glu Glu 2565 2570 2575
Asp Pro His Arg Glu Asp Val Ala Gin Arg Leu Ala Asn Ala Leu Thr 2580 2585 2590
Asp Ala Gly Gin Leu Gly Gly Val Leu Ser Leu Leu Gly Leu Asp Glu 2595 2600 2605
Ser Pro Ala Pro Gly Phe Ser Cys Leu Pro Thr Gly Phe Ala Leu Thr 2610 2615 2620
Val Gin Leu Leu Arg Ala Leu Arg Lys Ala Asp Val Glu Ala Pro Phe 2625 2630 2635 2640
Trp Ala Val Thr Arg Gly Gly Val Ala Leu Glu Asp Val Arg Val Ser 2645 2650 2655 本紙張又度適用中國國家標準（CNS ) Α4規格（21〇Χ297公釐） (請先閲讀背面之注意事項再填寫本頁)
，1T 秦· 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Pro Glu Gin Ala Leu Val Trp Gly Leu Leu Arg Val Ala Gly Leu Glu 2660 2665 2670
His Pro Glu Phe Trp Gly Gly Leu lie Asp Leu Pro Ser Asp Τΐφ Asp 2675 2680 2685 .Asp Arg Leu Gly Ala Arg Leu Ala Gly Val Leu Ala Asp Gly Gly Glu 2690 2695 2700
Asp Gin Val Ala lie Arg Arg Gly Gly Val Phe Val Arg Arg Leu Glu 2705 2710 2715 2720
Arg Ala Gly Ala Ser Gly Ala Gly Ser Val Trp Arg Pro Arg Gly Thr 2725 2730 2735
Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Ala His Val Ala Arg 2740 2745 2750
Trp Leu Ala Gly Ala Gly Ala Glu His Val Val Leu Thr Ser Arg Arg 2755 2760 2765
Gly Ala Asp Ala Pro Gly Ala Gly Glu Leu Arg Ala Glu Leu Glu Ala 2770 2775 2780
Leu Gly Ala Arg Val Ser lie Val Pro Cys Asp Val Ala Asp Arg Asp 2785 2790 2795 2800
Ala Val Ala Gly Val Leu Ala Gly lie Gly Gly Glu Cys Pro Leu Thr 2805 2810 2815
Ala Val Val His Ala Ala Gly Val Gly Glu Ala Gly Asp Val Val Glu 2820 2825 2830
Met Gly Leu Ala Asp Phe Ala Ala Val Leu Ser Ala Lys Val Arg Gly 2835 2840 2845
Ala Ala Asn Leu Asp Glu Leu Leu Ala Asp Ser Glu Leu Asp Ala Phe 2850 2855 2860
Val Met Phe Ser Ser Val Ser Gly Val Trp Gly Ala Gly Gly Gin Gly 2865 2870 2875 2880
Ala Tyr Ala Ala Ala Asn Ala Tyr Leu Asp Ala Leu Ala Glu Gin Arg 2885 2890 2895
Arg Ala Arg Gly Leu Val Gly Thr Ala Val Ala Trp Gly Pro Trp Ala -126 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（ 2900 2905 2910 Gly Asp Gly Met Ala Ala Gly Glu Thr Gly Ala Gin Leu His Arg Met 2915 2920 2925 Gly Leu Ala Ser Met Glu Pro Ser Ala Ala Leu Leu Ala Leu Gin Gly 2930 2935 2940 Ala Leu Asp Arg Asp Glu Thr Ser Leu Val Val Ala Asp Val Asp Trp 2945 2950 2955 Ala Arg Phe Ala Pro Ala Phe Thr Ser Ala Arg I 2965 2970 Asp Thr lie Asp Glu Ala Arg Ala Ala Leu Glu Ί 2980 2985 Ala Gly Thr Gly Lys Pro Val Glu Leu Thr Gin I 2995 3000 Ser Arg Lys Glu Arg Asp Asp Ala Val Leu Asp Leu Val Arg Ala Glu 3010 3015 3020 Thr Ala Ala Val Leu Gly Arg Asp Asp Ala Thr Ala Leu Ala Pro Ser 3025 3030 3035 3040 Arg Pro Phe Gin Glu Leu Gly Phe Asp Ser Leu Met Ala Val Glu Leu 3045 3050 3055 Arg Asn Arg Leu Asn Thr Ala Thr Gly lie Gin Leu Pro Ala Ser Thr 3060 3065 3070 工le Phe Asp Tyr Pro Asn Ala Glu Ser Leu Ser Arg His Leu Cys Ala 3075 3080 3085 Glu Leu Phe Pro Thr Glu Thr Thr Val Asp Ser Ala Leu Ala Glu Leu 3090 3095 3100 Asp Arg lie Glu Gin Gin Leu Ser Met Leu Thr Gly Glu Ala Arg Ala 3105 3110 3115 3120 Arg Asp Arg lie Ala Thr Arg Leu Arg Ala Leu His Glu Lys Trp Asn 3125 3130 3135 Ser Ala Ala Glu Val Pro Thr Gly Ala Asp Val Leu Ser Thr Leu Asp 3140 3145 3150 -127 - 2960 Arg Pro Leu Leu 2975 Thr Gly Glu Gin 2990 Leu Ala Gly Leu 3005 (請先閲讀背面之注意事項再填寫本頁) 訂 άφ. 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X 297公釐） 1237058 五、發明説明（）
Ser Ala Thr His Asp Glu lie Phe Glu Phe lie Asp Asn Glu Leu Asp 3155 3160 3165
Leu Ser 3170 (2)序列辨識號碼:5之資料： (i) 序列特徵： (A) 長度：4928個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:5
Val Glu lie Thr Met Ala Asn Glu Glu Lys Leu Phe Gly Tyr Leu Lys 1 5 10 15
Lys Val Thr Ala Asp Leu His Gin Thr Arg Gin Arg Leu Leu Ala Ala 20 25 30
Glu Ser Arg Ser Gin Glu Pro lie Ala lie Val Ser Ala Ser Cys Arg 35 40 45
Leu Pro Gly Gly Val Asp Ser Pro Glu Ala Leu Trp Gin Leu Val Arg 50 55 60
Thr Gly Thr Asp Ala lie Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp 65 70 75 80
Leu Gly Arg Leu Tyr Asp Pro Asp Pro Asn His Gin Gly Thr Ser Tyr 85 90 95
Thr Arg Ala Gly Gly Phe Leu Ala Gly Ala Gly Asp Phe Asp Pro Ala 100 105 110
Met Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin 115 120 125
Arg Leu Leu Leu Glu Leu Ser Trp Glu Ala Leu Glu Arg Ala Gly lie 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 130 135 140
Asp Pro Thr Ser Leu Arg Gly Ser Lys Thr Gly Val Phe Gly Gly Val 145 150 155 160
Thr Pro Gin Glu Tyr Gly Pro Ser Leu Gin Glu Met Ser Arg Asn Ala 165 170 175
Gly Gly Phe Gly Leu Thr Gly Arg Met Val Ser Val Ala Ser Gly Arg 180 185 190
Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr 195 200 205
Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Cys Gin Ser Leu 210 215 220
Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met 225 230 235 240
Ala Thr Pro Ala Thr Phe Val Glu Phe Ser Arg Gin Arg Gly Leu Ala 245 250 255
Pro Asp Gly Arg Cys Lys Ser Phe Ala Ala Ala Ala Asp Gly Thr Gly 260 265 270
Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp Ala 275 280 285
Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Val 290 295 300
Asn Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser 305 310 315 320
Gin Gin Arg Val lie Thr Gin Ala Leu Ala Ser Ala Gly Leu Ser Val 325 330
Ser Asp Val Asp Ala Val Glu Ala His Gly r 340 345
Asp Pro lie Glu Ala Gin Ala Leu lie Ala ' 355 360
Glu Lys Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly 370 375 380 '紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先聞讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印t 335 Gly Thr Thr Leu Gly 350 Tyr Gly Gin Gly Arg 365 1237058 A7 B7 五、發明説明（）
His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val Leu 385 390 395 400
Ala Met Arg His Gly Gin Leu Pro Ala Thr Leu His Val Asp Glu Pro 405 410 415 .Thr Ser Ala Val Asp Trp Ser Ala Gly Ser Val Arg Leu Leu Thr Glu 420 425 430
Asn Thr Pro Trp Pro Asp Ser Gly Arg Pro Cys Arg Val Gly Val Ser 435 440 445
Ser Phe Gly lie Ser Gly Thr Asn Ala His Val lie Leu Glu Gin Ser 450 455 460
Pro Val Glu Gin Gly Glu Pro Ala Gly Pro Val Glu Gly Glu Arg Glu 465 470 475 480
Pro Asp Val Ala Val Pro Val Val Pro Tip Val Leu Ser Gly Lys Thr 485 490 495
Pro Glu Ala Ala Arg Ala Gin Ala Glu Arg Val His Ser His lie Glu 500 505 510
Asp Arg Pro Gly Leu Ser Pro Val Asp Val Ala Tyr Ser Leu Gly Met 515 520 525
Thr Arg Ala Ala Leu Asp Glu Arg Ala Val Val Leu Gly Ser Asp Arg 530 535 540
Ala Ala Leu Leu Thr Gly Leu Arg Ala Phe Ala Asp Gly Cys Asp Ala 545 550 555 560
Pro Glu Val Val Ser Gly Ser Val Gly Leu Gly Gly Arg Val Gly Phe 565 570 575
Val Phe Ser Gly Gin Gly Gly Gin Trp Pro Gly Met Gly Arg Gly Leu 580 585 590
Tyr Ser Val Phe Pro Val Phe Ala Asp Ala Phe Asp Glu Ala Cys Ala 595 600 605
Glu Leu Asp Ala His Leu Gly Gin Glu Leu Arg Val Arg Asp Val Val 610 615 620
Phe Gly Ser Gin Ala Trp Leu Leu Asp Arg Thr Val Tip Ala Gin Ser 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 S. 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） 625 630 635 640
Gly Leu Phe Ala Leu Gin lie Gly Leu Leu Arg Leu Leu Gly Ser Trp 645 650 655
Gly Val Arg Pro Asp Val Val Leu Gly His Ser Val Gly Glu Leu Ala 660 665 670
Ala Val His Ala Ala Gly Val Leu Ser Leu Ser Glu Ala Ala Arg Leu 675 680 685
Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Ala 690 695 700
Met Leu Ala Val Ala Thr Gly Glu Phe Gin Val Asp Pro Leu Leu Asp 705 710 715 720
Gly Val Arg Asp Arg lie Gly lie Ala Ala Val Asn Gly Pro Glu Ser 725 730 735
Val Val Leu Ser Gly Asp Arg Glu Leu Leu Thr Glu lie Ala Asp Arg 740 745 750
Leu His Asp Gin Gly Cys Arg Thr Arg Trp Leu Arg Val Ser His Ala 755 760 765
Phe His Ser Pro His Met Glu Pro Met Leu Glu Glu Phe Ala Gin lie 770 775 780
Ser Arg Gly Arg Glu Tyr His Ala Pro Glu Leu Pro lie lie Ser Thr 785 790 795 800
Leu lie Gly Glu Leu Asp Gly Gly Arg Val Met Gly Thr Pro Glu Tyr 805 810 815
Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe Ala Glu Gly Val Gin 820 825 830
Ala Leu Val Gly Gin Gly Val Gly Thr lie Val Glu Leu Gly Pro Asp 835 840 845
Gly Ala Leu Ser Thr Leu Val Glu Glu Cys Val Ala Glu Ser Gly Arg 850 855 860
Val Ala Gly He Pro Leu Met Arg Lys Asp Arg Asp Glu Ala Arg Thr 865 870 875 880 -131 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 -秦· 經濟部智慧財產局員工消費合作#印絮 ^_____ 經濟部智慧財產局員工消費合作社印製 1237058 at B7 、發明説明（)
Val Leu Ala Ala Leu Ala Gin lie His Thr Arg Gly Gly Glu Val Asp 885 890 895
Trp Arg Ser Phe Phe Ala Gly Thr Gly Ala Lys Gin Val Asp Leu Pro 900 905 910
Thr Tyr Ala Phe Gin Arg Gin Arg Tyr Trp Leu Ala Ser Thr Gly Arg 915 920 925
Ala Gly Asp Val Thr Ala Ala Gly Leu Ala Glu Ala Asp His Pro Leu 930 935 940
Leu Gly Ala Val Val Ala Leu Ala Asp Gly Glu Gly Val Val Leu Thr 945 950 955 960
Gly Arg Leu Thr Ala Gly Ser His Pro Trp Leu Ser Asp His Arg Val 965 970 975
Leu Gly Glu lie Val Val Pro Gly Thr Ala lie Val Glu Leu Val Trp 980 985 990
His Val Gly Glu Arg Leu Gly Cys Gly Arg Val Glu Glu Leu Ala Leu 995 1000 1005
Glu Ala Pro Leu lie Leu Pro Asp His Gly Ala Val Gin Val Gin Val 1010 1015 1020
Leu Val Gly Pro Pro Gly Glu Ser Gly Ala Arg Ser Val Ala Leu Tyr 1025 1030 1035 1040
Ser Cys Pro Gly Glu Ala lie Glu Pro Glu Trp Lys Lys His Ala Thr 1045 1050 1055
Gly Val Leu Leu Pro Pro Val Ala Ala Glu Asn His Glu Leu Thr Ala 1060 1065 1070
Trp Pro Pro Glu Asn Ala Thr Glu lie Asp Ala Asp Gly Val Tyr Ala 1075 1080 1085
Phe Leu Glu Gly His Gly Phe Ala Tyr Gly Pro Ala Phe Arg Cys Leu 1090 1095 1100
Arg Gly Ala Trp Arg Arg Gly Gly Glu Val Phe Ala Glu Val Ala Leu 1105 1110 1115 1120
Pro Asp Asp Met Gin Ala Gly Val Asp Arg Phe Gly Val His Pro Ala 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 蠢· A7 B7 1135 Ser Val Val 1150 經濟部智慧財產局員工消費合作社印製 1237058 五、發明説明（ 1125 1130
Leu Leu Asp Ala Val Leu His Ala Ala Ala Ala Glu〔 1140 1145
Gin Ser Glu Ala Arg Val Pro Phe Ser Trp Arg Gly Val Glu Leu Arg 1155 1160 1165
Ala Thr Glu Ser Ala Val Val Arg Ala Arg Leu Ser Leu Thr Ser Asp 1170 1175 1180
Asp Glu Leu Ser Leu Val Ala Val Asp Pro Ala Gly Arg Phe Val Ala 1185 1190 1195 1200
Thr Val Asp Ser Leu Val Thr Arg Pro lie Ser Arg Gin Gin Val Arg 1205 1210 1215
Ser Gly Ala lie Gly Asp Cys Leu Phe Glu Val Glu Trp His Arg Lys 1220 1225 1230
Ala Leu Leu Gly Thr Thr Ala Gly Asp Asp Leu Ala lie Val Gly Asp 1235 1240 1245
Gly Pro Ser Trp Pro Glu Ser Val Arg Ala Thr Ala Arg Phe Ala Thr 1250 1255 1260
Leu Asp Glu Phe Arg Ala Ala Val Asp Ser Asp Val Pro Ala Pro Gly 1265 1270 1275 1280
Ser Val Leu Val Ala Ala Met Ser Ala Glu Glu Val Glu Gly Gly Ser 1285 1290 1295
Leu Pro Ser Arg Ala Gin Glu Ser Thr Ser Asp Leu Leu Ala Leu Val 1300 1305 1310
Gin Ser Trp Leu Ala Asp Glu Arg Phe Ala Glu Ser Gin Leu Val Val 1315 1320 1325
Val Thr Arg Ala Ala Val Ser Ala Asp Ser Asp Ser Asp Val Ala Asp 1330 1335 1340
Leu Val Gly Ala Ser Ser Trp Gly Leu Leu Ser Ser Ala Gin Ser Glu 1345 1350 1355 1360
Asn Pro Gly Arg Phe Val Leu Val Asp Val Asp Gly Thr Pro Glu Ser 1365 1370 1375 本紙張尺度適用中國國家標準（CNS ) A4規格（210X；297公釐） (請先閱讀背面之注意事項再填寫本頁)
1237058 A7 B7 五、發明説明（）
Trp Gin Ala Leu Pro Ala Ala Val Arg Ala Gly Glu Pro Gin Leu Ala 1380 1385 1390
Leu Arg Arg Gly Val Ala Leu Val Pro Arg Leu Ala Arg Leu Thr Val 1395 1400 1405
Arg Glu Glu Gly Ser Ser Pro Gin Leu Asp Thr Asp Gly Thr Val Leu 1410 1415 1420 lie Thr Gly Gly Thr Gly Ala Leu Gly Gly Val Val Ala Arg His Leu 1425 1430 1435 1440
Val Glu Glu His Gly lie Arg Arg Leu Val Leu Ala Gly Arg Arg Gly 1445 1450 1455
Trp Asn Ala Pro Gly Val His Glu Leu Val Asp Glu Leu Ala Arg Ala 1460 1465 1470
Gly Ala Val Val Glu Val Val Ala Cys Asp Val Ala Asp Arg Thr Asp 1475 1480 1485
Leu Glu His Val Leu Ala Ala lie Pro Val Asp Trp Pro Leu Arg Gly 1490 1495 1500 lie Val His Thr Ala Gly Val Leu Ala Asp Gly Val lie Gly Ser Leu 1505 1510 1515 1520
Ser Ala Ala Asp Val Gly Thr Val Phe Ala Pro Lys Val Thr Gly Ala 1525 1530 1535
Trp His Leu His Glu Leu Thr Arg Asp Leu Asp Leu Ser Phe Phe Val 1540 1545 1550
Leu Phe Ser Ser Phe Ser Gly lie Ala Gly Ala Ala Gly Gin Ala Asn 1555 1560 1565
Tyr Ala Ala Ala Asn Thr Phe Leu Asp Ala Leu Ala Arg Tyr Arg Arg 1570 1575 1580
Ala Arg Gly Leu Pro Gly Leu Ser Leu Ala Trp Gly Leu Trp Ala Gin 1585 1590 1595 1600
Pro Ser Gly Met Thr Ser Gly Leu Asp Ala Ala Ser Val Glu Arg Leu 1605 1610 1615
Ala Arg Thr Gly lie Ala Glu Leu Ser Thr Glu Asp Gly Leu Arg Leu -134 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 1620 1625 1630 (請先閲讀背面之注意事項再填寫本頁)
Phe Asp Ala Ala Phe Ala Lys Asp Arg Ala Cys Val Val Ala Ala Arg 1635 1640 1645
Leu Asp Arg Ala Leu Leu Val Gly Asn Gly Arg Ser His Ala lie Pro 1650 1655 1660
Ala Leu Leu Ser Ala Leu Val Pro Val Arg Gly Gly Val Ala Arg Lys 1665 1670 1675 1680
Thr Ala Asn Ser Gin Ala Ala Asp Glu Asp Ala Leu Leu Gly Leu Val 1685 1690 1695
Arg Glu His Val Ser Ala Val Leu Gly Tyr Ser Gly Ala Val Glu Val 1700 1705 1710
Gly Gly Asp Arg Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Ser Gly 1715 1720 1725
Val Glu Leu Arg Asn Arg Leu Ala Gly Val Leu Gly Val Arg Leu Pro 1730 1735 1740
Ala Thr Ala Val Phe Asp Tyr Pro Thr Pro Arg Ala Leu Ala Arg Phe 1745 1750 1755 1760
Leu His Gin Glu Leu Ala Gly Glu Val Ala Ser Thr Ser Thr Pro Val 1765 1770 1775
Thr Arg Ala Ala Ser Ala Glu Glu Asp Leu Val Ala lie Val Gly Met 1780 1785 1790
Gly Cys Arg Phe Pro Gly Gly Val Ser Ser Pro Glu Glu Leu Trp Arg 1795 1800 1805 絰濟部智慧財產局員工消費合作社印製
Leu Val Ala Gly Gly Val Asp Ala Val Ala Gly Phe Pro Asp Asp Arg 1810 1815 1820
Gly Trp Asp Leu Ala Ala Leu Tyr Asp Pro Asp Pro Asp Arg Leu Gly 1825 1830 1835 1840
Thr Ser Tyr Val Cys Glu Gly Gly Phe Leu Arg Asp Ala Ala Glu Phe 1845 1850 1855
Asp Ala Asp Met Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp 1860 1865 1870 -135 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210Χ：297公釐） 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Pro Gin Gin Arg Leu Leu Leu Glu Val Ala Trp Glu Thr Leu Glu Arg 1875 1880 1885
Ala Gly lie Asp Pro Phe Ser Leu His Gly Ser Arg Thr Gly Val Phe 1890 1895 1900 • Ala Gly Leu Met Tyr His Asp Tyr Gly Ala Arg Phe lie Thr Arg Ala 1905 1910 1915 1920
Pro Glu Gly Phe Glu Gly His Leu Gly Thr Gly Asn Ala Gly Ser Val 1925 1930 1935
Leu Ser Gly Arg Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val 1940 1945 1950
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 1955 I960 1965
Gly Gin Ala Leu Arg Ala Gly Glu Cys Glu Phe Ala Leu Ala Gly Gly 1970 1975 1980
Val Thr Val Met Ser Thr Pro Thr Thr Phe Val Glu Phe Ser Arg Gin 1985 1990 1995 2000
Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ala Ala Ala Ala 2005 2010 2015
Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg 2020 2025 2030
Leu Ser Asp Ala Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg 2035 2040 2045
Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 2050 2055 2060
Asn Gly Pro Ser Gin Gin Arg Val lie Thr Gin Ala Leu Thr Ser Ala 2065 2070 2075 2080
Gly Leu Ser Val Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly 2085 2090 2095
Thr Arg Leu Gly Asp Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr 2100 2105 2110
Gly Arg Asp Arg Asp Pro Gly Arg Pro Leu Trp Leu Gly Ser Val Lys 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁)
1237058 at B7 五、發明説明（） 2115 2120 2125 (請先閱讀背面之注意事項再填寫本頁)
Ser Asn lie Gly His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie 2130 2135 2140
Lys Met Val Met Ala Met Arg Gin Gly Glu Leu Pro Arg Thr Leu His 2145 2150 2155 2160
Val Asp Glu Pro Ser Ala Gin Val Asp Trp Ser Ala Gly Thr Val Gin 2165 2170 2175
Leu Leu Thr Glu Asn Thr Pro Trp Pro Asp Ser Gly Arg Leu Arg Arg 2180 2185 2190
Ala Gly Val Ser Ser Phe Gly lie Ser Gly Thr Asn Ala His L白ii lie 2195 2200 2205
Leu Glu Gin Pro Pro Arg Glu Ser Gin Arg Ser Thr Glu Pro Asp Ser 2210 2215 2220
Gly Ser Val Arg Asp Phe Pro Val Val Pro Trp Met Val Ser Gly Lys 2225 2230 2235 2240
Thr Pro Glu Ala Leu Ser Ala Gin Ala Asp Ala Leu Met Ser Tyr Leu 2245 2250 2255
Ser Asn Arg Val Asp Ala Ser Pro Arg Asp lie Gly Tyr Ser Leu Ala 2260 2265 2270
Val Thr Arg Pro Ala Leu Asp His Arg Ala Val Val Leu Gly Ala Asp 2275 2280 2285
Arg Ala Ala Leu Leu Pro Gly Leu Lys Ala Leu Ala Val Ser Asn Asp 2290 2295 2300 經濟部智慧財產局員工消費合作社印製
Ala Ala Glu Val lie Thr Gly Thr Arg Ala Ala Gly Pro Val Gly Phe 2305 2310 2315 2320
Val Phe Ser Gly Gin Gly Gly Gin Trp Pro Gly Met Gly Ser Gly Leu 2325 2330 2335
His Ser Ala Phe Pro Val Phe Ala Asp Ala Phe Asp Glu Ala Cys Cys 2340 2345 2350
Glu Leu Asp Ala His Leu Gly Gin Met Ala Arg Leu Arg Asp Val Leu 2355 2360 2365 -137 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（）
Ser Gly Ser Asp Thr Gin Leu Leu Asp Gin Thr Leu Trp Ala Gin Pro 2370 2375 2380 (請先閲讀背面之注意事項再填寫本頁)
Gly Leu Phe Ala Leu Gin Val Gly Leu Trp Glu Leu Leu Gly Ser Trp 2385 2390 2395 2400 .Gly Val Arg Pro Ala Val Val Leu Gly His Ser Val Gly Glu Leu Ala 2405 2410 2415
Ala Ala Phe Ala Ala Gly Val Leu Ser Leu Arg Asp Ala Ala Arg Leu 2420 2425 2430
Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu Pro Thr Gly Gly Ala 2435 2440 2445
Met Leu Ala Ala Ala Ala Gly Glu Glu Gin Leu Arg Pro Leu Leu Ala 2450 2455 2460
Asp Cys Gly Asp Arg Val Gly lie Ala Ala Val Asn Ala Pro Gly Ser 2465 2470 2475 2480
Val Val Leu Ser Gly Asp Arg Asp Val Leu Asp Asp lie Ala Gly Arg 2485 2490 2495
Leu Asp Gly Gin Gly lie Arg Ser Arg Trp Leu Arg Val Ser His Ala 2500 2505 2510
Phe His Ser His Arg Met Asp Pro Met Leu Ala Glu Phe Thr Glu lie 2515 2520 2525
Ala Arg Ser Val Asp Tyr Arg Ser Ser Gly Leu Pro lie Val Ser Thr 2530 2535 2540
Leu Thr Gly Glu Leu Asp Glu Val Gly Met Pro Ala Thr Pro Glu Tyr 經濟部智慧財產局員工消費合作社印製 2545 2550 2555 2560
Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Ala 2565 2570 2575
Ala Leu Ala Ala His Gly Val Ser Thr Val Val Glu Val Gly Pro Asp 2580 2585 2590
Gly Val Leu Ser Ala Leu Val Gin Glu Cys Ala Ala Gly Ser Asp Gin 2595 2600 2605
Gly Gly Arg Val Ala Ala Val Pro Leu Met Arg Ser Asn Arg Asp Glu -138 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（） 2610 2615 2620
Ala His Thr Val Thr Thr Ala Leu Ala Gin lie His Val Arg Gly Ala 2625 2630 2635 2640
Glu Val Asp Trp Arg Ser Phe Phe Ala Gly Thr Gly Ala Lys Gin Val 2645 2650 2655
Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin Arg Tyr Trp Leu Asp Ser 2660 2665 2670
Pro Ser Glu Pro Val Gly Gin Ser Ala Asp Pro Ala Arg Gin Ser Gly 2675 2680 2685
Phe Trp Glu Leu Val Glu Gin Glu Asp Val Ser Ala Leu Ser Ala Ala 2690 2695 2700
Leu His lie Thr Gly Asp His Asp Val Gin Ala Ser Leu Glu Ser Val 2705 2710 2715 2720
Val Pro Val Leu Ser Ser Trp His Arg Arg lie Arg Asn Glu Ser Leu 2725 2730 2735
Val His Gin Trp Arg Tyr Arg lie Ser Trp His Glu Arg Ala Asp Leu 2740 2745 2750
Pro Asp Pro Ser Leu Ser Gly Thr Trp Leu Val Val Val Pro Glu Gly 2755 2760 2765
Trp Ser Ala Ser Arg Gin Val Leu Arg Phe Asn Glu Met Phe Glu Glu 2770 2775 2780
Arg Gly Cys Pro Ala Val Leu Phe Glu Leu Ala Gly His Asp Glu Glu 2785 2790 2795 2800
Ala Leu Ala Gin Arg Phe Arg Ser Leu Pro Val Ala Ser Gly Gly lie 2805 2810 2815
Ser Gly Val Leu Ser Leu Leu Ala Leu Asp Glu Ser Pro Ser Ser Pro 2820 2825 2830
Asn Ala Ala Leu Pro Asn Gly Ala Leu Asn Ser Leu Val Leu Leu Arg 2835 2840 2845
Ala Leu Arg Ala Ala Asp Val Ser Ala Pro Leu Trp Leu Ala Thr Cys 2850 2855 2860 -139 - 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先閲讀背面之注意事項再填寫本頁)
-、1T 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（)
Gly Gly Val Ala Val Gly Asp Val Pro Val Asn Pro Gly Gin Ala Leu 2865 2870 2875 2880
Val Trp Gly Leu Gly Arg Val Val Gly Leu Glu His Pro Ala Trp Trp 2885 2890 2895 .Gly Gly Leu Val Asp Val Pro Cys Leu Leu Asp Glu Asp Ala Arg Glu 2900 2905 2910 ) 2925 Arg Leu Glu . Arg Ala Gly Ala Ala 2940 Pro Arg Gly Thr Val Leu Val Thr 2955 2960
Arg Leu Ser Val Val Leu Ala Gly Leu Gly Glu Asp Glu lie Ala Val 2915 2920
Arg Pro Gly Gly Val Phe Val Ά 2930 2935
Ser Gly Ala Gly Ser Val Trp Ά 2945 2950
Trp Leu Ala Gly 2975 Gly Ala Ala Ala 2990
Gly Gly Thr Gly Gly Leu Gly Ala His Val Ala 2965 2970
Ala Gly Ala Glu His Val Val Leu Thr Ser Arg 2980 2985
Pro Gly Ala Gly Asp Leu Arg Ala Glu Leu Glu Ala Leu Gly Ala Arg 2995 Val Ser lie 1 3010 Val Leu Ala 3025 3000 3005
Ala Cys Asp Val Ala Asp Arg Asp Ala Leu Ala Glu 3015 3020 工le Pro Asp Asp Cys Pro Leu Thr Ala Val Met His 3030 3035 3040 經濟部智慧財產局員工消費合作社印製 (請先閱讀背面之注意事項再填寫本頁)
Ala Ala Gly Val Val Glu Val Gly Asp Val Ala Ser Met Cys Leu Thr 3045 3050 3055
Asp Phe Val Gly Val Leu Ser Ala Lys Ala Gly Gly Ala Ala Asn Leu 3060 3065 3070
Asp Glu Leu Leu Ala Asp Val Glu Leu Asp Ala Phe Val Leu Phe Ser 3075 3080 3085
Ser Val Ser Gly Val Trp Gly Ala Gly Gly Gin Gly Ala Tyr Ala Ala 3090 3095 3100
Ala Asn Ala Tyr Leu Asp Ala Leu Ala Gin Gin Arg Arg Ala Arg Gly 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 3105 3110 3115 3120
Leu Val Gly Thr Ala Val Ala Trp Gly Pro Trp Ala Gly Asp Gly Met 3125 3130 3135
Ala Ala Gly Glu Gly Gly Ala Gin Leu Arg Arg Ala Gly Leu Val Pro 3140 3145 3150
Met Ala Ala Asp Arg Ala Leu Leu Ala Leu Gin Gly Ala Leu Asp Arg 3155 3160 3165
Asp Glu Thr Ser Leu Val Val Ala Asp Met Ala Trp Glu Arg Phe Ala 3170 3175 3180
Pro Val Phe Ala Met Ser Arg Arg Arg Pro Leu Leu Asp Glu Leu Pro 3185 3190 3195 3200
Glu Ala Gin Gin Ala Leu Ala Asp Ala Glu Asn Thr Thr Asp Ala Ala 3205 3210 3215
Asp Ser Ala Val Pro Leu Pro Arg Leu Ala Gly Met Ala Ala Ala Glu 3220 3225 3230
Arg Arg Arg Ala Met Leu Asp Leu Val Leu Ala Glu Ala Ser lie Val 3235 3240 3245
Leu Gly His Asn Gly Ser Asp Pro Val Gly Pro Asp Arg Ala Phe Gin 3250 3255 3260
Glu Leu Gly Phe Asp Ser Leu Met Ala Val Glu Leu Arg Asn Arg Leu 3265 3270 3275 3280
Gly Glu Ala Thr Gly Leu Ser Leu Pro Ala Thr Leu lie Phe Asp Tyr 3285 3290 3295
Pro Ser Pro Ser Ala Leu Ala Glu Gin Leu Val Gly Glu Leu Val Gly 3300 3305 3310
Ala Gin Pro Ala Thr Thr Val Val Ala Gly Ala Asp Pro Val Asp Asp 3315 3320 3325
Pro Val Val Val Val Ala Met Gly Cys Arg Tyr Pro Gly Asp Val Cys 3330 3335 3340
Ser Pro Glu Glu Leu Trp Gin Leu Val Ser Ala Gly Arg Asp Ala Val 3345 3350 3355 3360 -141 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） -------^------------訂------線^~ (請先閱讀背面之注意事項再填寫本頁) 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Ser Thr Phe Pro Val Asp Arg Gly Trp Asp Cys Asn Thr Leu Phe Asp 3365 3370 3375
Pro Asp Pro Asp Arg Ala Gly Ser Thr Tyr Val Arg Glu Gly Ala Phe 3380 3385 3390 .Leu Thr Gly Ala Asp Arg Phe Asp Ala Gly Phe Phe Gly lie Ser Pro 3395 3400 3405
Arg Glu Ala Arg Ala Met Asp Pro Gin Gin Arg Leu Leu Leu Glu Val 3410 3415 3420
Ala Trp Glu Val Phe Glu Arg Ala Gly lie Ala Pro Leu Ser Leu Arg 3425 3430 3435 3440
Gly Ser Arg Thr Gly Val Phe Ala Gly Thr Asn Gly Gin Asp His Gly 3445 3450 3455
Ala Lys Val Ala Ala Ala Pro Glu Ala Ala Gly His Leu Leu Thr Gly 3460 3465 3470
Asn Ala Ala Ser Val Leu Ala Gly Arg Leu Ser Tyr Thr Phe Gly Leu 3475 3480 3485
Glu Gly Pro Ala Val Ala Val Asp Thr Ala Cys Ser Ser Ser Leu Val 3490 3495 3500
Ala Leu His Leu Ala Cys Gin Ser Leu Arg Ser Gly Glu Cys Asp Met 3505 3510 3515 3520
Ala Leu Ala Gly Gly Val Thr Val Met Ser Thr Pro Leu Ala Phe Leu 3525 3530 3535
Glu Phe Ser Arg Gin Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser 3540 3545 3550
Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Leu 3555 3560 3565
Val Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Arg Val 3570 3575 3580
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn 3585 3590 3595 3600
Gly Leu Thr Ala Pro Asn Gly Pro Ser Gin Gin Arg Val lie Arg Gin 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） -----—^-----------訂------線^~ (請先閱讀背面之注意事項再填寫本頁) 1237058 at B7 五、發明説明（） 3605 3610 3615
Ala Leu Ala Asn Ala Gly Leu Ser Ala Ser Asp Val Asp Val Val Glu 3620 3625 3630
Ala His Gly Thr Gly Thr Gly Leu Gly Asp Pro lie Glu Ala Gin Ala 3635 3640 3645
Leu lie Ala Thr Tyr Gly Gin Glu Arg Asp Pro Glu Arg Ala Leu Trp 3650 3655 3660
Leu Gly Ser lie Lys Ser Asn lie Gly His Thr Gin Ala Ala Ala Gly 3665 3670 3675 3680
Val Ala Gly Val lie Lys Met Val Gin Ala Met Arg His Gly Glu Leu 3685 3690 3695
Pro Ala Thr Leu His Val Asp Lys Pro Thr Pro Gin Val Asp Trp Ser 3700 3705 3710
Ala Gly Ala Val Arg Leu Leu Thr Gly Asn Thr Pro Trp Pro Glu Ser 3715 3720 3725
Gly Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly lie Ser Gly Thr 3730 3735 3740
Asn Ala His Leu lie Leu Glu Gin Pro Pro Ser Glu Pro Ala Glu lie 3745 3750 3755 3760
Asp Gin Ser Asp Arg Arg Val Thr Ala His Pro Ala Val lie Pro Trp 3765 3770 3775
Met Leu Ser Ala Arg Ser Leu Ala Ala Leu Gin Ala Gin Ala Ala Ala 3780 3785 3790
Leu Gin Ala Arg Leu Asp Arg Gly Pro Gly Ala Ser Pro Leu Asp Leu 3795 3800 3805
Gly Tyr Ser Leu Ala Thr Thr Arg Ser Val Leu Asp Glu Arg Ala Val 3810 3815 3820
Val Trp Gly Ala Asp Arg Glu Ala Leu Leu Ser Arg Leu Ala Ala Leu 3825 3830 3835 3840
Ala Asp Gly Arg Thr Ala Pro Gly Val lie Thr Gly Ser Ala Asn Ser 3845 3850 3855 -143 - 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇'〆297公釐） (請先閲讀背面之注意事項再填寫本頁) -訂 線·- 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Gly Gly Arg lie Gly Phe Val Phe Ser Gly Gin Gly Ser Gin Trp Leu 3860 3865 3870
Gly Met Gly Lys Ala Leu Cys Ala Ala Phe Pro Ala Phe Ala Asp Ala 3875 3880 3885
Phe Glu Glu Ala Cys Asp Ala Leu Ser Ala His Leu Gly Ala Asp Val 3890 3895 3900
Arg Gly Val Leu Phe Gly Ala Asp Glu Gin Met Leu Asp Arg Thr Leu 3905 3910 3915 3920
Trp Ala Gin Ser Gly lie Phe Ala Val Gin Val Gly Leu Leu Gly Leu 3925 3930 3935
Leu Arg Ser Trp Gly Val Arg Pro Ala Ala Val Leu Gly His Ser Val 3940 3945 3950
Gly Glu Leu Ala Ala Ala His Ala Ala Gly Val Leu Ser Leu Pro Asp 3955 3960 3965
Ala Ala Arg Leu Val Ala Ala Arg Ala His Leu Met Gin Ala Leu Pro 3970 3975 3980
Thr Gly Gly Ala Met Leu Ala Val Ala Thr Ser Glu Ala Ala Val Gly 3985 3990 3995 4000
Pro Leu Leu Ser Gly Val Cys Asp Arg Val Ser lie Ala Ala lie Asn 4005 4010 4015
Gly Pro Glu Ser Val Val Leu Ser Gly Asp Arg Asp Val Leu Val Glu 4020 4025 4030
Leu Ala Gly Glu Phe Asp Ala Arg Gly Leu Arg Thr Lys Trp Leu Arg 4035 4040 4045
Val Ser His Ala Phe His Ser His Arg Met Glu Pro lie Leu Asp Glu 4050 4055 4060
Tyr Ala Glu Thr Ala Arg Cys Val Glu Phe Gly Glu Pro Val Val Pro 4065 4070 4075 4080 工le Val Ser Ala Ala Thr Gly Ala Leu Asp Thr Thr Gly Leu Met Cys 4085 4090 4095
Ala Ala Asp Tyr Trp Thr Arg Gin Val Arg Asp Pro Val Arg Phe Gly 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 4100 4105 4110
Asp Gly Val Arg Ala Leu Val Gly Gin Gly Val Asp Thr lie Val Glu 4115 4120 4125
Phe Gly Pro Asp Gly Ala Leu Ser Ala Leu Val Glu Gin Cys Leu Ala 4130 4135 4140
Gly Ser Asp Gin Ala Gly Arg Val Ala Ala He Pro Leu Met Arg Arg 4145 4150 4155 4160
Asp Arg Asp Glu Val Glu Thr Ala Val Ala Ala Leu Ala His Val His 4165 4170 4175
Val Arg Gly Gly Ala Val Asp Trp Ser Ala Cys Phe Ala Gly Thr Gly 4180 4185 4190
Ala Arg Thr Val Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin Arg Tyr 4195 4200 4205 Ίτρ Leu Ala Gly Gin Ala Asp Gly Arg Gly Gly Asp Val Val Ala Asp 4210 4215 4220
Pro Val Asp Ala Arg Phe Trp Glu Leu Val Glu Arg Ala Asp Pro Glu 4225 4230 4235 4240
Pro Leu Val Asp Glu Leu Cys 工 le Asp Arg Asp Gin Pro Phe Arg Glu 4245 4250 4255
Val Leu Pro Val Leu Ala Ser Trp Arg Glu Lys Gin Arg Gin Glu Ala 4260 4265 4270
Leu Ala Asp Ser Trp Arg Tyr Gin Val Arg Trp Arg Ser Val Glu Val 4275 4280 4285
Pro Ser Ala Ala Ala Leu Arg Gly Val Tirp Leu Val Val Leu Pro Ala 4290 4295 4300
Asp Val Pro Arg Asp Gin Pro Ala Val Val lie Asp Ala Leu lie Ala 4305 4310 4315 4320
Arg Gly Ala Glu Val Ala Val Leu Glu Leu Thr Glu Gin Asp Leu Gin 4325 4330 4335
Arg Ser Ala Leu Val Asp Lys Val Arg Ala Val lie Ala Asp Arg Thr 4340 4345 4350 本紙張尺度適用中國國家標準（CNS ) A4規格（21〇Χ：297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 k#. 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Glu Val Thr Gly Val Leu Ser Leu Leu Ala Met Asp Gly Met Pro Cys 4355 4360 4365
Ala Ala His Pro His Leu Ser Arg Gly Val Ala Ala Thr Val He Leu 4370 4375 4380 .Thr Gin Val Leu Gly Asp Ala Gly Val Ser Ala Pro Leu Trp Leu Ala 4385 4390 4395 4400
Thr Thr Gly Gly Val Glu Ala Gly Thr Glu Asp Gly Pro Ala Asp Pro 4405 4410 4415
Asp His Gly Leu lie Trp Gly Leu Gly Arg Val Val Gly Leu Glu His 4420 4425 4430
Pro Gin Trp Trp Gly Gly Leu lie Asp Leu Pro Glu Thr Leu Asp Glu 4435 4440 4445
Thr Ser Arg Asn Gly Leu Val Ala Ala Leu Ala Gly Thr Ala Ala Glu 4450 4455 4460
Asp Gin Leu Ala Val Arg Ser Ser Gly Leu Phe Val Arg Arg Val Val 4465 4470 4475 4480
Arg Ala Ala Arg Asn Pro Arg Ser Glu Thr Trp Arg Ser Arg Gly Thr 4485 4490 4495
Val Leu lie Thr Gly Gly Thr Gly Ala Leu Gly Ala Glu Val Ala Arg 4500 4505 4510
Trp Leu Ala Arg Arg Gly Ala Glu His Leu Val Leu lie Ser Arg Arg 4515 4520 4525
Gly Pro Glu Ala Pro Gly Ala Ala Asp Leu Gly Ala Glu Leu Thr Glu 4530 4535 4540
Leu Gly Val Lys Val Thr Val Leu Ala Cys Asp Val Thr Asp Arg Asp 4545 4550 4555 4560
Glu Leu Ala Ala Val Leu Ala Ala Val Pro Thr Glu Tyr Pro Leu Ser 4565 4570 4575
Ala Val Val His Thr Ala Gly Val Gly Thr Pro Ala Asn Leu Ala Glu 4580 4585 4590
Thr Thr Leu Ala Gin Phe Ala Asp Val Leu Ser Ala Lys Val Val Gly -146 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） -IT---4, (請先閲讀背面之注意事項再填寫本頁) 訂 -線a— 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） 4595 4600 4605
Ala Ala Asn Leu Asp Arg Leu Leu Gly Gly Gin Pro Leu Asp Ala Phe 4610 4615 4620
Val Leu Phe Ser Ser He Ser Gly Val Trp Gly Ala Gly Gly Gin Gly 4625 4630 4635 4640
Ala Tyr Ser Ala Ala Asn Ala Tyr Leu Asp Ala Leu Ala Glu Arg Arg 4645 4650 4655
Arg Ala Cys Gly Arg Pro Ala Thr Cys lie Ala Trp Gly Pro Trp Ala 4660 4665 4670
Gly Ala Gly Met Ala Val Gin Glu Gly Asn Glu Ala His Leu Arg Arg 4675 4680 4685
Arg Gly Leu Val Pro Met Glu Pro Gin Ser Ala Leu Phe Ala Leu Gin 4690 4695 4700
Gin Ala Leu Ser Gin Arg Glu Thr Ala lie Thr Val Ala Asp Val Asp 4705 4710 4715 4720
Trp Glu Arg Phe Ala Ala Ser Phe Thr Ala Ala Arg Pro Arg Pro Leu 4725 4730 4735
Leu Glu Glu lie Val Asp Leu Arg Pro Asp Thr Glu Thr Glu Glu Lys 4740 4745 4750
His Gly Ala Gly Glu Leu Gly Gin Gin Leu Ala Ala Leu Pro Pro Ala 4755 4760 4765
Glu Arg Gly His Leu Leu Leu Glu Val Val Leu Ala Glu Thr Ala Ser 4770 4775 4780
Thr Leu Gly His Asp Ser Ala Glu Ala Val Gin Pro Asp Arg Thr Phe 4785 4790 4795 4800
Ala Glu Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg 4805 4810 4815
Leu Asn Ala Val Thr Gly Leu Arg Leu Pro Pro Thr Leu Val Phe Asp 4820 4825 4830
His Pro Thr Pro Leu Ala Leu Ser Glu Gin Leu Val Pro Ala Leu Val 4835 4840 4845 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 A7 B7 五、發明説明（）
Ala Glu Pro Asp Asn Gly lie Glu Ser Leu Leu Ala Glu Leu Asp Arg 4850 4855 4860
Leu Asp Thr Thr Leu Ala Gin Gly Pro Ser lie Pro Leu Glu Asp Gin 4865 4870 4875 4880
Ala Lys Val Ala Glu Arg Leu His Ala Leu Leu Ala Lys Trp Asp Gly 4885 4890 4895
Ala Arg Asp Gly Thr Ala Arg Ala Thr Ser Pro Gin Ser Leu Thr Ala 4900 4905 4910
Ala Thr Asp Asp Glu lie Phe Asp Leu lie Asp Arg Lys Phe Arg Arg 4915 4920 4925 (2)序列辨識號碼:6之資料： (i)序列特徵： (A) 長度：5588個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ϋ)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:6
Met Ala Asn Glu Glu Lys Leu Arg Glu Tyr Leu Lys Arg Val Val Val 15 10 15
Glu Leu Glu Glu Ala His Glu Arg Leu His Glu Leu Glu Arg Gin Glu 20 25 30
His Asp Pro 工le Ala lie Val Ser Met Gly Cys Arg Tyr Pro Gly Gly 35 40 45
Val Ser Thr Pro Glu Glu Leu Trp Arg Leu Val Val Asp Gly Gly Asp 50 55 60
Ala lie Ala Asn Phe Pro Glu Asp Arg Gly Trp Asn Leu Asp Glu Leu 65 70 75 80
Phe Asp Pro Asp Pro Gly Arg Ala Gly Thr Ser Tyr Val Arg Glu Gly 85 90 95 -148 - 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
Gly Phe Leu Arg Gly Val Ala Asp Phe Asp Ala Gly Leu Phe Gly lie 100 105 HO Ser Pro Arg Glu Ala Gin Ala Met Asp Pro Gin Gin Arg Leu Leu Leu 115 120 125 Glu lie Ser Trp Glu Val Phe Glu Arg Ala Gly lie Asp Pro Phe Ser 130 135 140 Leu Arg Gly Thr Lys Thr Gly Val Phe Ala Gly Leu lie Tyr His Asp 150 155 160 [Phe Arg Lys Thr Pro Ala Glu Phe Glu Gly Tyr Phe 145 Tyr Ala Ser 165 170 Ala Thr Gly Asn Ala Gly Ser Val Ala Ser Gly , 180 185 Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp ' 195 200 Ser Leu Val Ala Leu His Leu Ala Cys Gin Ser Leu Arg Leu Gly Glu 210 215 220 Cys Asp Leu Ala Leu Ala Gly Gly lie Ser Val Met Ala 225 230 235 Ala Phe Val Glu Phe Ser Arg Gin Arg Ala Leu Ala Ser 245 250 Cys Lys Pro Phe Ala Asp Ala Ala Asp Gly Thr Gly Trp Gly Glu Gly 260 265 270 Ala Gly Met Leu Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly 275 280 285 His Pro Val Leu Ala Ala Val Val Gly Ser Ala lie Asn Gin Asp Gly 290 295 300 Thr Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gin Gin Arg Val 305 310 315 320 工le Arg Gin Ala Leu Ala Asn Ala Gly Leu Ser Pro Ala Glu Val Asp 325 330 335 Val Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro lie Glu -149 - 175 Val Ala Tyr Thr 190 Ala Cys Ser Ser 205
Pro Gly 240 Gly Arg 255 (請先閲讀背面之注意事項再填寫本頁) 訂 kv.. 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 A7 B7 五、發明説明（ 340 345 350
Ala Gin Ala Leu lie Ala Thr Tyr Gly Ala Asn Arg Ser Ala Asp His 355 360 365
Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn lie Gly His Thr Gin Ala 370 375 380
Ala Ala Gly Val Ala Gly Val lie Lys Ser Val Leu Ala lie Arg His 385 390 395 400
Arg Glu Met Pro Arg Ser Leu His lie Asp Gin Pro Ser Gin His Val 405 410 415
Asp Trp Ser Ala Gly Ala Val Arg Leu Leu Thr Asp Ser Val Asp Trp 420 425 430
Pro Asp Leu Gly Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Met 435 440 445
Ser Gly Thr Asn Ala His Leu lie Val Glu Glu Val Ser Asp Glu Pro (請先閲讀背面之注意事項再填寫本頁) 450 455 Val Ser Gly Ser Thr Glu Pro 460 經濟部智慧財產局員工消費合作社印製 * Gly Ala Phe Pro Trp Pro Leu Ser 475 480 f Glu Gin Ala Ala Glu Leu Leu Ser 490 495 Glu His Pro Glu Pro Gly Leu Gly Asp Val Gly Tyr Ser 500 505 510 Gly Arg Ala Ala Met Glu His Arg Ala Val Val Val Ala 515 520 525 Asp Asp Arg Asp Ser Phe Val Ala Gly Leu Thr Ala Leu Ala Ala Gly 530 535 540 Val Pro Ala Ala Asn Val Val Gin Gly Ala Ala Asp Cys Lys Gly Lys 545 550 555 560 Val Ala Phe Val Phe Pro Gly Gin Gly Ser His Trp Gin Gly Met Ala 565 570 575 Arg Glu Leu Ser Glu Ser Ser Pro Val Phe Arg Arg Lys Leu Ala Glu 580 585 590 -150 - 465 Gly Lys Val Val Leu Ala 470 Glu Thr Ala Leu 485
,tT 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（）
Cys Ala Ala Ala Thr Ala Pro Tyr Val Asp Trp Ser Leu Leu Gly Val 595 600 605
Leu Arg Gly Asp Pro Asp Ala Pro Ala Leu Asp Arg Asp Asp Val lie 610 615 620
Gin Leu Ala Leu Phe Ala Met Met Val Ser Leu Ala Glu Leu Trp Arg 625 630 635 640
Ser Cys Gly Val Glu Pro Ala Ala Val Val Gly His Ser Gin Gly Glu 645 650 655 工le Ala Ala Ala His Val Ala Gly Ala Leu Ser Leu Thr Asp Ala Val 660 665 670
Arg lie lie Ala Ala Arg Cys Asp Ala Val Ser Ala Leu Thr Gly Lys 675 680 685
Gly Gly Met Leu Ala lie Ala Leu Pro Glu Ser Ala Val Val Lys Arg 690 695 700 工 le Ala Gly Leu Pro Glu Leu Thr Val Ala Ala Val Asn Gly Pro Gly 705 710 715 720
Ser Thr Val Val Ser Gly Glu Pro Ser Ala Leu Glu Arg Leu Gin Thr 725 730 735
Glu Leu Thr Ala Glu Asn Val Gin Thr Arg Arg Val Gly lie Asp Tyr 740 745 750
Ala Ser His Ser Pro Gin lie Ala Gin Val Gin Gly Arg Leu Leu Asp 755 760 765
Arg Leu Gly Glu Val Gly Ser Glu Pro Ala Glu lie Ala Phe Tyr Ser 770 775 780
Thr Val Thr Gly Glu Arg Thr Asp Thr Gly Arg Leu Asp Ala Asp Tyr 785 790 795 800
Trp Tyr Gin Asn Leu Arg Gin Pro Val Arg Phe Gin Gin Thr Val Ala 805 810 815
Arg Met Ala Asp Gin Gly Tyr Arg Phe Phe Val Glu Val Ser Pro His 820 825 830
Pro Leu Leu Thr Ala Gly lie Gin Glu Thr Leu Glu Ala Ala Asp Ala -151 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 S. 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 835 840 845
Gly Gly Val Val Val Gly Ser Leu Arg Arg Gly Glu Gly Gly Ser Arg 850 855 860
Arg Trp Leu Thr Ser Leu Ala Glu Cys Gin Val Arg Gly Leu Pro Val 865 870 875 880
Asn Trp Glu Gin Val Phe Leu Asn Thr Gly Ala Arg Arg Val Pro Leu 885 890 895
Pro Thr Tyr Pro Phe Gin Arg Gin Arg Tyr Trp Leu Glu Ser Ala Glu 900 905 910
Tyr Asp Ala Gly Asp Leu Gly Ser Val Gly Leu Leu Ser Ala Glu His 915 920 925
Pro Leu Leu Gly Ala Ala Val Thr Leu Ala Asp Ala Gly Gly Phe Leu 930 935 940
Leu Thr Gly Lys Leu Ser Val Lys Thr Gin Pro Trp Leu Ala Asp His 945 950 955 960
Val Val Gly Gly Ala lie Leu Leu Pro Gly Thr Ala Phe Val Glu Met 965 970 975
Leu lie Arg Ala Ala Asp Gin Val Gly Cys Asp Leu lie Glu Glu Leu 980 985 990
Ser Leu Thr Thr Pro Leu Val Leu Pro Ala Thr Gly Ala Val Gin Val 995 1000 1005
Gin lie Ala Val Gly Gly Pro Asp Glu Ala Gly Arg Arg Ser Val Arg 1010 1015 1020
Val His Ser Cys Arg Asp Asp Ala Val Pro Gin Asp Ser Trp Thr Cys 1025 1030 1035 1040
His Ala Thr Gly Thr Leu Thr Ser Ser Asp His Gin Asp Ala Gly Gin 1045 1050 1055
Gly Pro Asp Gly lie Trp Pro Pro Asn Asp Ala Val Ala Val Pro Leu 1060 1065 1070
Asp Ser Phe Tyr Ala Arg Ala Ala Glu Arg Gly Phe Asp Phe Gly Pro 1075 1080 1085 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Ala Phe Gin Gly Leu Gin Ala Ala Trp Lys Arg Gly Asp Glu lie Phe 1090 1095 1100 (請先閲讀背面之注意事項再填寫本頁)
Ala Glu Val Gly Leu Pro Thr Ala His Arg Glu Asp Ala Gly Arg Phe 1105 1110 1115 1120
Gly lie His Pro Ala Leu Leu Asp Ala Ala Leu Gin Ala Leu Gly Ala 1125 1130 1135
Ala Glu Glu Asp Pro Asp Glu Gly Trp Leu Pro Phe Ala Trp Gin Gly 1140 1145 1150
Val Ser Leu Lys Ala Thr Gly Ala Leu Ser Leu Arg Val His Leu Val 1155 1160 1165
Pro Ala Gly Ala Asn Ala Val Ser Val Phe Thr Thr Asp Thr Thr Gly 1170 1175 1180
Gin Ala Val Leu Ser lie Asp Ser Leu Val Leu Arg Gin lie Ser Asp 1185 1190 1195 1200
Lys Gin Leu Ala Ala Ala Arg Ala Met Glu His Glu Ser Leu Phe Arg 1205 1210 1215
Val Asp Trp Lys Arg lie Ser Pro Gly Ala Ala Lys Pro Val Ser Trp 1220 1225 1230
Ala Val lie Gly Asn Asp Glu Leu Ala Arg Ala Cys Gly Ser Ala Leu 1235 1240 1245
Gly Thr Glu Leu His Pro Asp Leu Thr Gly Leu Ala Asp Pro Pro Pro 1250 1255 1260
Asp Val Val Val Val Pro Cys Gly Ala Ser Arg Gin Asp Leu Asp Val 1265 1270 1275 1280 經濟部智慧財產局員工消費合作社印製
Ala Ser Glu Ala Arg Ala Ala Thr Gin Arg Met Leu Asp Leu lie Gin 1285 1290 1295
Asp Trp Leu Ala Ala Ala Arg Phe Ala Gly Ser Arg Leu Val Val Val 1300 1305 1310
Thr Cys Gly Ala Ala Ser Thr Gly Pro Ala Glu Gly Val Ser Asp Leu 1315 1320 1325
Val His Ala Ala Ser Trp Gly Leu Leu Arg Ser Ala Gin Ser Glu Asn 本紙張尺度適用中國國家標準（CNS ) A4規格（210X：297公釐） 五 _ 經濟部智慧財產局員工消費合作社印製 1237058 at B7 、發明説明（） 1330 1335 1340
Pro Asp Arg Phe Val Leu Val Asp Val Asp Gly Thr Ala Glu Ser Trp 1345 1350 1355 1360
Arg Ala Leu Ala Ala Ala Val Arg Ser Gly Glu Pro Gin Leu Ala Leu 1365 1370 1375
Arg Ala Gly Glu Val Arg Val Pro Arg Leu Ala Arg Cys Val Ala Ala 1380 1385 1390
Glu Asp Ser Arg lie Pro Val Pro Gly Ala Asp Gly Thr Val Leu lie 1395 1400 1405
Ser Gly Gly Thr Gly Leu Leu Gly Gly Leu Val Ala Arg His Leu Val 1410 1415 1420
Ala Glu Arg Gly Val Arg Arg Leu Val Leu Ala Gly Arg Arg Gly Trp 1425 1430 1435 1440
Ser Ala Pro Gly Val Thr Asp Leu Val Asp Glu Leu Val Gly Leu Gly 1445 1450 1455
Ala Ala Val Glu Val Ala Ser Cys Asp Val Gly Asp Arg Ala Gin Leu 1460 1465 1470
Asp Arg Leu Leu Thr Thr lie Ser Ala Glu Phe Pro Leu Arg Gly Val 1475 1480 1485
Val His Ala Ala Gly Ala Leu Ala Asp Gly Val Val Glu Ser Leu Thr 1490 1495 1500
Pro Glu His Val Ala Lys Val Phe Gly Pro Lys Ala Ala Gly Ala Trp 1505 1510 1515 1520
His Leu His Glu Leu Thr Leu Asp Leu Asp Leu Ser Phe Phe Val Leu 1525 1530 1535
Phe Ser Ser Phe Ser Gly Val Ala Gly Ala Ala Gly Gin Gly Asn Tyr 1540 1545 1550
Ala Ala Ala Asn Ala Phe Leu Asp Gly Leu Ala Gin His Arg Arg Thr 1555 1560 1565
Ala Gly Leu Pro Ala Val Ser Leu Ala Tip Gly Leu Trp Glu Gin Pro 1570 1575 1580 -154 - .紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 S. 1237058 A7 B7 五、發明説明（）
Ser Gly Met Thr Gly Ala Leu Asp Ala Ala Gly Arg Ser Arg lie Ala 1585 1590 1595 1600
Arg Thr Asn Pro Pro Met Ser Ala Pro Asp Gly Leu Arg Leu Phe Glu 1605 1610 1615
Met Ala Phe Arg Val Pro Gly Glu Ser Leu Leu Val Pro Val His Val 1620 1625 1630
Asp Leu Asn Ala Leu Arg Ala Asp Ala Ala Asp Gly Gly Val Pro Ala 1635 1640 1645
Leu Leu Arg Asp Leu Val Pro Ala Pro Val Arg Arg Ser Ala Val Asn 1650 1655 1660
Glu Ser Ala Asp Val Asn Gly Leu Val Gly Arg Leu Axg Arg Leu Pro 1665 1670 1675 1680
Asp Leu Asp Gin Glu Thr Gin Leu Leu Gly Leu Val Arg Glu His Val 1685 1690 1695
Ser Ala Val Leu Gly His Ser Gly Ala Val Glu Val Gly Ala Asp Arg 1700 1705 1710
Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Ser Gly Val Glu Phe Arg 1715 1720 1725
Asn Arg Leu Gly Gly Val Leu Gly Val Arg Leu Pro Ala Thr Ala Val 1730 1735 1740
Phe Asp Tyr Pro Thr Pro Arg Ala Leu Val Arg Phe Leu Leu Asp Lys 1750 1755 1760
Leu lie Gly Gly Val Glu Ala Pro Thr Pro Ala Pro Ala Ala Val Ala 1765 1770 1775
Ala Val Thr Ala Asp Asp Pro Val Val lie Val Gly Met Gly Cys Arg 1780 1785 1790
Tyr Pro Gly Gly Val Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Ala 1795 1800 1805
Gly Gly Leu Asp Ala Val Ala Glu Phe Pro Asp Asp Arg Gly Trp Asp 1810 1815 1820
Gin Ala Gly Leu Phe Asp Pro Asp Pro Asp Arg Leu Gly Thr Ser Tyr -155 - 本紙張又度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先閲讀背面之注意事項再填寫本頁)
，1T 經濟部智慧財產局員工消費合作社印製 五 _ 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 、發明説明（） 1825 1830 1835 1840
Val Cys Glu Gly Gly Phe Leu Arg Asp Ala Ala Glu Phe Asp Ala Gly 1845 1850 1855
Phe Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin 1860 1865 1870
Arg Leu Leu Leu Glu Val Ala Txp Glu Thr Val Glu Arg Ala Gly lie 1875 1880 1885
Asp Pro Leu Ser Leu Arg Gly Ser Arg Thr Gly Val Phe Ala Gly Leu 1890 1895 1900
Met His His Asp Tyr Gly Ala Arg Phe lie Thr Arg Ala Pro Glu Gly 1905 1910 1915 1920
Phe Glu Gly Tyr Leu Gly Asn Gly Ser Ala Gly Gly Val Phe Ser Gly 1925 1930 1935
Arg Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp 1940 1945 1950
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gin Ala 1955 1960 1965
Leu Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val 1970 1975 1980
Met Ala Thr Pro Gly Met Phe Val Glu Phe Ser Arg Gin Arg Gly Leu 1985 1990 1995 2000
Ala Ala Asp Gly Arg Cys Lys Ser Phe Ala Ala Ala Ala Asp Gly Thr 2005 2010 2015
Gly Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp 2020 2025 2030
Ala Arg Arg Asn Gly His Ala Val Leu Ala Val Val Arg Gly Ser Ala 2035 2040 2045
Val Asn Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro 2050 2055 2060
Ser Gin Gin Arg Val lie Thr Gin Ala Leu Ala Ser Ala Gly Leu Ser 2065 2070 2075 2080 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 1237058 A7 B7 五、發明説明（）
Val Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu 2085 2090 2095
Gly Asp Pro 工le Glu Ala Gin Ala Leu lie Ala Thr Tyr Gly Gin Gly 2100 2105 2110 Arg Asp Ser Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie 2115 2120 2125
Gly His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val 2130 2135 2140
Met Ala Met Arg His Gly Gin Leu Pro Ala Thr Leu His Val Asp Glu 2145 2150 2155 2160
Pro Thr Ser Glu Val Asp Trp Ser Ala Gly Asp Val Gin Leu Leu T3ir 2165 2170 2175
Glu Asn Thr Pro Trp Pro Gly Asn Ser His Pro Arg Arg Val Gly Val 2180 2185 2190
Ser Ser Phe Gly lie Ser Gly Thr Asn Ala His Val lie Leu Glu Gin 2195 2200 2205
Ala Ser Lys Thr Pro Asp Glu Thr Ala Asp Lys Ser Gly Pro Asp Ser 2210 2215 2220
Glu Ser Thr Val Asp Leu Pro Ala Val Pro Leu lie Val Ser Gly Arg 2225 2230 2235 2240
Thr Pro Ala Ala Leu Ser Ala Gin Ala Ser Ala Leu Leu Ser Tyr Leu 2245 2250 2255
Gly Glu Arg Gly Asp lie Ser Thr Leu Asp Ala Ala Phe Ser Leu Ala 2260 2265 2270
Ser Ser Arg Ala Ala Leu Glu Glu Arg Ala Val Val Leu Gly Ala Asp 2275 2280 2285
Arg Glu Thr Leu Leu Ser Gly Leu Glu Ala Leu Ala Ser Gly Arg Glu 2290 2295 2300
Ala Ser Gly Val Val Ser Gly Ser Pro Val Ser Gly Gly Val Gly Phe 2305 2310 2315 2320
Val Phe Ala Gly Gin Gly Gly Gin Trp Leu Gly Met Gly Arg Gly Leu -157 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（ 2325 2330 2335
Tyr Ser Val Phe Pro Val Phe Ala Asp Ala Phe Asp Glu Ala Cys Ala 2340 2345 2350
Gly Leu Asp Ala His Leu Gly Gin Asp Val Gly Val Arg Asp Val Val 2355 2360 2365
Phe Gly Ser Asp Gly Ser Leu Leu Asp Arg Thr Leu Trp Ala Gin Ser 2370 2375 2380
Gly Leu Phe Ala Leu Gin Val Gly Leu Leu Ser Leu Leu Gly Ser Trp 2385 2390 2395 2400
Gly Val Arg Pro Gly Val Val Leu Gly His Ser Val Gly Glu Phe Ala 2405 2410 2415
Ala Ala Val Ala Ala Gly Val Leu Ser Leu Pro Asp Ala Ala Arg Met 2420 2425 2430
Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Ala 2435 2440 2445
Met Leu Ala Val Ala Ala Gly Glu Glu Gin Leu Arg Pro Leu Leu Ala 2450 2455 2460
Asp Arg Val Asp Gly Ala Gly lie Ala Ala Val Asn Ala Pro Glu Ser 2465 2470 2475 2480
Val Val Leu Ser Gly Asp Arg Glu Val Leu Asp Asp lie Ala Gly Ala 2485 2490 2495
Leu Asp Gly Gin Gly lie Arg Trp Arg Arg Leu Arg Val Ser His Ala 2505 2510 > Pro Met Leu Gin Glu Phe Ala Glu lie 2520 2525
Ala Arg Ser Val Asp Tyr Arg Arg Gly Asp Leu Pro Val Val Ser Thr 2530 2535 2540
Leu Thr Gly Glu Leu Asp Thr Ala Gly Val Met Ala Thr Pro Glu Tyr 2545 2550 2555 2560
Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Arg 2565 2570 2575 本紙張尺度適用中國國家標準（CNS ) A4規格（210X；297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 2500 Phe His Ser Tyr Arg Met 2515 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（）
Val Leu Ala Gin Gin Gly Val Ala Thr lie Phe Glu Leu Gly Pro Asp 2580 2585 2590 Ala Thr Leu Ser Ala Leu lie Pro Asp Cys His Ser Trp Ala Asp Gin 2595 2600 Ala Met Pro lie Pro Met Leu Arg Lys Asp 2610 2615 Val Val Ala Ala Val Ala Arg Ala His Thr 2625 2630 2605 Arg Thr Glu Thr Glu Thr 2620 Arg Gly Val Pro Val Glu 2635 2640
Trp Ser Ala Tyr Phe Ala Gly Thr Gly Ala Arg Arg Val Glu Leu Pro 2645 2650 2655 Thr Tyr Ala Phe Gin Arg Gin Arg Tyr Ίτρ Leu Glu Thr Ser Asp Tyr 2660 2665 2670 Gly Asp Val Thr Gly lie Gly Leu Ala Ala Ala Glu His Pro Leu Leu 2675 2680 2685 Gly Ala Val Val Ala Leu Ala Asp Gly Asp Gly Met Val Leu Thr Gly 2690 2695 2700 Arg Leu Ser Val Gly Thr His Pro Trp Leu Ala Gin His Arg Val Leu 2705 2710 2715 2720 Gly Glu Val Val Val Pro Gly Thr Ala lie Leu Glu Met Ala Leu His 2725 Ala Gly Ala Arg Leu Gly Cys 2740 Thr Pro Leu Val Val Pro Glu 2755 2730 2735 Asp Arg Val Glu Glu Leu Thr Leu Glu 2745 2750 Arg Ala Ala Gly Ala Gly Ser Arg Gly 2760 2765 [Val
Pro Ala Gly Gly Thr Thr Val Ser lie Glu Thr Ala Glu Glu 1 _ 2770 2775 2780 Arg Thr Asn Asp Ala lie Glu lie Gin Leu Leu Val Asn Ala Pro Asp 2785 2790 2795 2800 Glu Gly Gly Arg Arg Arg Val Ser Leu Tyr Ser Arg Pro Ala Gly Gly 2805 2810 2815 Ser Arg Gly Gly Gly Trp Thr Arg His Ala Thr Gly Glu Leu Val Val -159 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 2830 Ser Ala Glu Gly Ala 2845 1237058 A7 B7 五、發明説明（） 2820 2825
Gly Thr Thr Gly Gly Arg Ala Val Pro Asp ： 2835 2840
Glu Ser He Ala Leu Asp Glu Phe Tyr Val Ala Leu Ala Gly Asn Gly 2850 2855 2860
Phe Glu Tyr Gly Pro Leu Phe Gin Gly Leu Gin Ala Ala Trp Arg Arg 2865 2870 2875 2880
Gly Asp Glu Val Leu Ala Glu lie Ala Pro Pro Ala Glu Ala Asp Ala 2885 2890 2895
Met Ala Ser Gly Tyr Leu Leu Asp Pro Ala Leu Leu Asp Ala Ala Leu 2900 2905 2910
Gin Ala Ser Ala Leu Gly Asp Arg Pro Glu Gin Gly Gly Ala Trp Leu 2915 2920 2925
Pro Phe Ser Phe Thr Gly Val Glu Leu Ser Ala Pro Ala Gly Thr lie 2930 2935 2940
Ser Arg Val Arg Leu Glu Thr Arg Arg Pro Asp Ala lie Ser Val Ala 2945 2950 2955 2960
Val Met Asp Glu Ser Gly Arg Leu Leu Ala Ser lie Asp Ser Leu Arg 2965 2970 2975
Leu Arg Ser Val Ser Ser Gly Gin Leu Ala Asn Arg Asp Ala Val Arg 2980 2985 2990
Asp Ala Leu Phe Glu Val Thr Trp Glu Pro Val Ala Thr Gin Ser Thr 2995 3000 3005
Glu Pro Gly Arg Trp Ala Leu Leu Gly Asp Thr Ala Cys Gly Lys Asp 3010 3015 3020
Asp Leu lie Lys Leu Ala Thr Asp Ser Ala Asp Arg Cys Ala Asp Leu 3025 3030 3035 3040
Ala Ala Leu Ala Glu Lys Leu Asp Ser Ser Ala Leu Val Pro Asp Val 3045 3050 3055
Val Val Tyr Cys Ala Gly Glu Gin Ala Asp Pro Gly Thr Gly Ala Ala 3060 3065 3070 -160 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（）
Ala Leu Ala Glu Thr Gin Gin Thr Leu Ala Leu Leu Gin Ala Trp Leu 3075 3080 3085
Ala Glu Pro Arg Leu Ala Glu Ala Arg Leu Val Val Val Thr Cys Ala 3090 3095 3100
Ala Val Thr Thr Ala Pro Ser Asp Gly Ala Ser Glu Leu Ala His Ala 3105 3110 3115 3120
Pro Leu Trp Gly Leu Leu Arg Ala Ala Gin Val Glu Asn Pro Gly Gin 3125 3130 3135
Phe Val Leu Ala Asp Val Asp Gly Thr Ala Glu Ser Trp Arg Ala Leu 3140 3145 3150
Pro Ser Ala Leu Gly Ser Met Glu Pro Gin Leu Ala Leu Arg Lys Gly 3155 3160 3165
Ala Val Arg Ala Pro Arg Leu Ala Ser Val Ala Gly Gin lie Asp Val 3170 3175 3180
Pro Ala Val Val Ala Asp Pro Asp Arg Thr Val Leu lie Ser Gly Gly 3185 3190 3195 3200
Thr Gly Leu Leu Gly Gly Ala Val Ala Arg His Leu Val Thr Glu Arg 3205 3210 3215
Gly Val Arg Arg Leu Val Leu Thr Gly Arg Arg Gly Trp Asp Ala Pro 3220 3225 3230
Gly lie Thr Glu Leu Val Gly Glu Leu Asn Gly Leu Gly Ala Val Val 3235 3240 3245
Asp Val Val Ala Cys Asp Val Ala Asp Arg Ala Asp Leu Glu Ser Leu 3250 3255 3260
Leu Ala Ala Val Pro Ala Glu Phe Pro Leu Cys Gly Val Val His Ala 3265 3270 3275 3280
Ala Gly Ala Leu Ala Asp Gly Val lie Glu Ser Leu Ser Pro Asp Asp 3285 3290 3295
Val Gly Ala Val Phe Gly Pro Lys Ala Ala Gly Ala Trp Asn Leu His 3300 3305 3310
Glu Leu Thr Arg Asp Tlir Asp Leu Ser Phe Phe Ala Leu Phe Ser Ser -161 - ^紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 3315 3320 3325
Leu Ser Gly Val Ala Gly Ala Pro Gly Gin Gly Asn Tyr Ala Ala Ala 3330 3335 3340
Asn Ala Phe Leu Asp Ala Leu Ala His Tyr Arg Arg Ser Gin Gly Leu 3345 3350 3355 3360
Pro Ala Val Ser Leu Ala Trp Gly Leu Trp Glu Gin Pro Ser Gly Met 3365 3370 3375
Thr Glu Thr Leu Ser Glu Val Asp Arg Ser Arg lie Ala Arg Ala Asn 3380 3385 3390
Pro Pro Leu Ser Thr Lys Glu Gly Leu Arg Leu Phe Asp Ala Gly Leu 3395 3400 3405
Ala Leu Asp Arg Ala Ala Val Val Pro Ala Lys Leu Asp Arg Thr Phe 3410 3415 3420
Leu Ala Glu Gin Ala Arg Ser Gly Ser Leu Pro Ala Leu Leu Thr Ala 3425 3430 3435 3440
Leu Val Pro Pro lie Arg Arg Asn Arg Arg Ala Ser Gly Thr Glu Leu 3445 3450 3455
Ala Asp Glu Gly Thr Leu Leu Gly Val Val Arg Glu His Ala Ala Ala 3460 3465 3470
Val Leu Gly Tyr Ser Ser Ala Ala Asp Val Gly Val Glu Arg Ala Phe 3475 3480 3485
Arg Asp Leu Gly Phe Asp Ser Leu Ser Gly Val Glu Leu Arg Asn Arg 3490 3495 3500
Leu Ala Gly Val Leu Gly Val Arg Leu Pro Ala Thr Ala Val Phe Asp 3505 3510 3515 3520
Tyr Pro Thr Pro Arg Ala Leu Ala Arg Phe Leu His Gin Glu Leu Ala 3525 3530 3535
Asp Glu lie Ala Thr Thr Pro Ala Pro Val Thr Thr Thr Arg Ala Pro 3540 3545 3550
Val Ala Glu Asp Asp Leu Val Ala lie Val Gly Met Gly Cys Arg Phe 3555 3560 3565 -162 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 s. 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） Pro Gly Gin Val Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Ala Gly 3570 3575 3580 Gly Val Asp Ala Val Ala Asp Phe Pro Ala Asp Arg Gly Trp Asp Leu 3585 3590 3595 3600 Ala Gly Leu Phe Asp Pro Asp Pro Glu Arg Ala Gly Lys Thr Tyr Val 3605 3610 3615 Arg Glu Gly Ala Phe Leu Thr Asp Ala Asp Arg Phe Asp Ala Gly Phe 3620 3625 3630 Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin Arg 3635 3640 3645 Leu Leu Leu Glu Leu Ser Trp Glu Ala lie Glu Arg Ala Gly lie Asp 3650 3655 3660 Pro Gly Ser Leu Arg Gly Ser Arg Thr Gly Val Phe Ala Gly Leu Met 3665 3670 3675 3680 Tyr His Asp Tyr Gly Ala Arg Phe Ala Ser Arg Ala Pro Glu Gly Phe 3685 3690 3695 Glu Gly Tyr Leu Gly Asn Gly Ser Ala Gly Ser Val Ala Ser Gly Arg 3700 3705 3710 工le Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr 3715 3720 3725 Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gin Ser Leu 3730 3735 3740 Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met 3745 3750 3755 3760 Ser Thr Pro Gly Thr Phe Val Glu Phe Ser Arg Gin Arg Gly Leu Ala 3765 3770 3775 Pro Asp Gly Arg Cys Lys Ser Phe Ala Glu Ser Ala Asp Gly Thr Gly 3780 3785 3790 Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp Ala 3795 3800 3805 Arg Arg Asn Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val -163 - (請先閲讀背面之注意事項再填寫本頁) 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（） 3810 3815 Asn Gin Asp Gly Ala Ser Asn Gly Leu 3825 3830 3820 Ala Pro Asn Gly Pro Ser 3835 3840
Gin Gin Arg Val lie Gin Gin Ala Leu Ala Ser Ala Gly Leu Ser Val 經濟部智慧財產局員工消費合作社印製 3845 3850 Ser Asp Val Asp Ala Val Glu Ala His Gly *] 3860 3865 Asp Pro lie Glu Ala Gin Ala Leu lie Ala 1 3875 3880 Asp Pro Gly Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly 3890 3895 3900 His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val Met 3905 3910 3915 3920 Ala Met Arg His Gly Gin Leu Pro Arg Thr Leu His Val Asp Ala Pro 3925 3930 3935 Ser Ser Gin Val Asp Trp Ser Ala Gly Arg Val Gin Leu Leu Thr Glu 3940 3945 3950 Asn Thr Pro Trp Pro Asp Ser Gly Arg Pro Cys Arg Val Gly Val Ser 3955 3960 3965 Ser Phe Gly lie Ser Gly Thr Asn Ala His Val lie Leu Glu Gin Ser 3970 3975 3980 Thr Gly Gin Met Asp Gin Ala Ala Glu Pro Asp Ser Ser Pro Val Leu 3985 3990 3995 4000 Asp Val Pro Val Val Pro Trp Val Val Ser Gly Lys Thr Pro Glu Ala 4005 4010 4015 Leu Ser Ala Gin Ala Ala Thr Leu Ala Thr Tyr Leu Asp Gin Asn Val 4020 4025 4030 Asp Val Ser Pro Leu Asp Val Gly lie Ser Leu Ala Val Thr Arg Ser 4035 4040 4045 Ala Leu Asp Glu Arg Ala Val Val Leu Gly Ser Asp I 4050 4055 4060 -164 - 3855 Gly Thr Arg Leu Gly 3870 Tyr Gly Arg Asp Arg 3885
Leu (請先閲讀背面之注意事項再填寫本頁) 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 1237058 at B7 五、發明説明（）
Leu Ser Gly Leu Asn Ala Leu Ala Ala Gly His Glu Ala Ala Gly Val 4065 4070 4075 4080
Val Thr Gly Pro Val Gly He Gly Gly Arg Thr Gly Phe Val Phe Ala 4085 4090 4095
Gly Gin Gly Gly Gin Trp Leu Gly Met Gly Arg Arg Leu Tyr Ser Glu 4100 4105 4110
Phe Pro Ala Phe Ala Gly Ala Phe Asp Glu Ala Cys Ala Glu Leu Asp 4115 4120 4125
Ala Asn Leu Gly Arg Glu Val Gly Val Arg Asp Val Val Phe Gly Ser 4130 4135 4140
Asp Glu Ser Leu Leu Asp Arg Thr Leu Trp Ala Gin Ser Gly Leu Phe 4145 4150 · 4155 4160
Ala Leu Gin Val Gly Leu Trp Glu Leu Leu Gly Thr Trp Gly Val Arg 4165 4170 4175
Pro Ser Val Val Leu Gly His Ser Val Gly Glu Leu Ala Ala Ala Phe 4180 4185 4190
Ala Ala Gly Val Ijeu Ser Met Ala Glu Ala Ala Arg Leu Val Ala Gly 4195 4200 4205
Arg Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Ala Met Leu Ala 4210 4215 4220
Val Ser Ala Thr Glu Ala Arg Val Gly Pro Leu Leu Asp Gly Val Arg 4225 4230 4235 4240
Asp Arg Val Gly Val Ala Ala Val Asn Ala Pro Gly Ser Val Val Leu 4245 4250 4255
Ser Gly Asp Arg Asp Val Leu Asp Gly lie Ala Gly Arg Leu Asp Gly 4260 4265 4270
Gin Gly lie Arg Ser Arg Trp Leu Arg Val Ser His Ala Phe His Ser 4275 4280 4285
His Arg Met Asp Pro Met Leu Ala Glu Phe Ala Glu Leu Ala Arg Ser 4290 4295 4300
Val Asp Tyr Arg Ser Pro Arg Leu Pro lie Val Ser Thr Leu Thr Gly -165 - 本紙張又度適用中國國家標準（CNS ) A4規格（210 X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 S. 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（) 4305 4310 4315 4320
Asn Leu Asp Asp Val Gly Val Met Ala Thr Pro Glu Tyr Trp Val Arg 4325 4330 4335
Gin Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Gin Ala Leu Val 4340 4345 4350
Asp Gin Gly Val Asp Thr lie Val Glu Leu Gly Pro Asp Gly Ala Leu 4355 4360 4365
Ser Ser Leu Val Gin Glu Cys Val Ala Glu Ser Gly Arg Ala Thr Gly 4370 4375 4380 工le Pro Leu Val Arg Arg Asp Arg Asp Glu Val Arg Thr Val Leu Asp 4385 4390 4395 4400
Ala Leu Ala Gin Thr His Thr Arg Gly Gly Ala Val Asp Trp Gly Ser 4405 4410 4415
Phe Phe Ala Gly Thr Arg Ala Thr Gin Val Asp Leu Pro Thr Tyr Ala 4420 4425 4430
Phe Gin Arg Gin Arg Tyr Trp Leu Glu Pro Ser Asp Ser Gly Asp Val 4435 4440 4445
Thr Gly Val Gly Leu Thr Gly Ala Glu His Pro Leu Leu Gly Ala Val 4450 4455 4460
Val Pro Val Ala Gly Gly Asp Glu Val Leu Leu Thr Gly Arg Leu Ser 4465 4470 4475 4480
Val Gly Thr His Pro Trp Leu Ala Glu His Arg Val Leu Gly Glu Val 4485 4490 4495
Val Val Pro Gly Thr Ala Leu Leu Glu Met Ala Trp Arg Ala Gly Ser 4500 4505 4510
Gin Val Gly Cys Glu Arg Val Glu Glu Leu Thr Leu Glu Ala Pro Leu 4515 4520 4525
Val Leu Pro Glu Arg Gly Ala Ala Ala Val Gin Leu Ala Val Gly Ala 4530 4535 4540
Pro Asp Glu Ala Gly Arg Arg Ser Leu Gin Leu Tyr Ser Arg Gly Ala 4545 4550 4555 4560 -166 - 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Asp Glu Asp Gly Asp Trp Arg Arg lie Ala Ser Gly Leu Leu Ala Gin 4565 4570 4575
Ala Asn Ala Val Pro Pro Ala Asp Ser Thr Ala Trp Pro Pro Asp Gly 4580 4585 4590
Ala Gly Gin Val Asp Leu Ala Glu Phe Tyr Glu Arg Leu Ala Glu Arg 4595 4600 4605
Gly Leu Thr Tyr Gly Pro Val Phe Gin Gly Leu Arg Ala Ala Trp Arg 4610 4615 4620
His Gly Asp Asp lie Phe Ala Glu Leu Ala Gly Ser Pro Asp Ala Ser 4625 4630 4635 4640
Gly Phe Gly 工le His Pro Ala Leu Leu Asp Ala Ala Leu His Ala Met 4645 4650 4655
Ala Leu Gly Ala Ser Pro Asp Ser Glu Ala Arg Leu Pro Phe Ser Trp 4660 4665 4670
Arg Gly Ala Gin Leu Tyr Arg Ala Glu Gly Ala Ala Leu Arg Val Arg 4675 4680 4685
Leu Ser Pro Leu Gly Ser Gly Ala Val Ser Leu Thr Leu Val Asp Ala 4690 4695 4700
Thr Gly Arg Arg Val Ala Ala Val Glu Ser Leu Ser Thr Arg Pro Val 4705 4710 4715 4720
Ser Thr Asp Gin lie Gly Ala Gly Arg Gly Asp Gin Glu Arg Leu Leu 4725 4730 4735
His Val Glu Trp Val Arg Ser Ala Glu Ser Ala Gly Met Ser Leu Thr 4740 4745 4750
Ser Cys Ala Val Val Gly Leu Gly Glu Pro Glu Trp His Ala Ala Leu 4755 4760 4765
Lys Thr Thr Gly Val Gin Val Glu Ser His Ala Asp Leu Ala Ser Leu 4770 4775 4780
Ala Thr Glu Val Ala Lys Arg Gly Ser Ala Pro Gly Ala Val lie Val 4785 4790 4795 4800
Pro Cys Pro Arg Pro Arg Ala Met Gin Glu Leu Pro Thr Ala Ala Arg 本紙張又度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先聞讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 __Γ 1237058 A7 B7 五、發明説明（） 4805 4810 4815
Arg Ala Thr Gin Gin Ala Met Ala Met Leu Gin Gin Trp Leu Ala Asp 4820 4825 4830
Asp Arg Phe Val Ser Thr Arg Leu lie Leu Leu Thr His Arg Ala Val 4835 4840 4845
Ser Ala Val Ala Gly Glu Asp Val Leu Asp Leu Val His Ala Pro Leu 4850 4855 4860
Trp Gly Leu Val Arg Ser Ala Gin Ala Glu His Pro Asp Arg Phe Ala 4865 4870 4875 4880
Leu lie Asp Met Asp Asp Glu Arg Ala Ser Gin Thr Ala Leu Ala Glu 4885 4890 4895
Ala Leu Thr Ala Gly Glu Ala Gin Leu Ala Val Arg Ser Gly Val Val 4900 4905 4910
Leu Ala Pro Arg Leu Gly Gin Val Lys Val Ser Gly Gly Glu Ala Phe 4915 4920 4925
Arg Trp Asp Glu Gly Thr Val Leu Val Thr Gly Gly Thr Gly Gly Leu 4930 4935 4940
Gly Ala Leu Leu Ala Arg His Leu Val Ser Ala His Gly Val Arg His 4945 4950 4955 4960
Leu Leu Leu Ala Ser Arg Arg Gly Leu Ala Ala Pro Gly Ala Asp Glu 4965 4970 4975
Leu Val Ala Glu Leu Glu Gin Ala Gly Ala Asp Val Ala Val Val Ala 4980 4985 4990
Cys Asp Ser Ala Asp Arg Asp Ser Leu Ala Arg Leu Val Ala Ser Val 4995 5000 5005
Pro Ala Glu Asn Pro Leu Arg Val Val Val His Ala Ala Gly Val Leu 5010 5015 5020
Asp Asp Gly Val Leu Met Ser Met Ser Pro Glu Arg Leu Asp Ala Val 5025 5030 5035 5040
Leu Arg Pro Lys Val Asp Ala Ala Trp Tyr Leu His Glu Leu Thr Arg 5045 5050 5055 -168 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 A7 經濟部智慧財產局員工消費合作社印製 1237058 B7 五、發明説明（）
Glu Leu Gly Leu Ser Ala Phe Val Leu Phe Ser Ser Val Ala Gly Leu 5060 5065 5070
Phe Gly Gly Ala Gly Gin Ser Asn Tyr Ala Ala Gly Asn Ala Phe Leu 5075 5080 5085
Asp Ala Leu Ala His Cys Arg Gin Ala Gin Gly Leu Pro Ala Leu Ser 5090 5095 5100
Leu Ala Ser Gly Leu Trp Ala Ser lie Asp Gly Met Ala Gly Asp Leu 5105 5110 5115 5120
Ala Ala Ala Asp Val Glu Arg Leu Ser Arg Ala Gly lie Gly Pro Leu 5125 5130 5135
Ser Ala Pro Gly Gly Leu Ala Leu Phe Asp Ala Ala Val Gly Ser Asp 5140 5145 5150
Glu Pro Leu Leu Ala Pro Val Arg Leu Asp Val Glu Ala Leu Arg Val 5155 5160 5165
Gin Ala Arg Ser Val Gin Thr Arg lie Pro Glu Met Leu His Gly Met 5170 5175 5180
Ala Met Gly Pro Ser Arg Arg Thr Pro Phe Thr Ser Arg Val Glu Pro 5185 5190 5195 5200
Leu His Glu Arg Leu Ala Gly Leu Ser Glu Gly Glu Arg Arg Gin Gin 5205 5210 5215
Val Leu Gin Arg Val Arg Ala Asp lie Ala Val Val Leu Gly His Gly 5220 5225 5230
Arg Ser Ser Asp Val Asp lie Glu Lys Pro Leu Ala Glu Leu Gly Phe 5235 5240 5245
Asp Ser Leu Thr Ala lie Glu Leu Arg Asn Arg Leu Ala Thr Ala Thr 5250 5255 5260
Gly Leu Arg Leu Pro Ala Thr Leu Ala Phe Asp His Gly Thr Ala Ala 5265 5270 5275 5280
Ala Leu Ala Gin His Val Cys Ala Gin Leu Gly Thr Ala Thr Ala Pro 5285 5290 5295
Ala Pro Arg Arg Thr Asp Asp Asn Asp Ala Thr Glu Pro Val Arg Ser 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁)
1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） 5300 5305 Leu Phe Gin Gin Ala Tyr Ala Ala Gly J 5315 5320 Leu Val Lys Val Ala Ala Gin Leu Arg Pro Val Phe Gly Ser Pro Gly 5330 5335 5340 Glu Leu Glu Ser Leu Pro Lys Pro Val Gin Leu Ser Arg Gly Pro Glu 5345 5350 5355 5360 Glu Leu Ala Leu Val Cys Met Pro Ala Leu lie Gly Met Pro Pro Ala 5365 5370 5375 Gin Gin Tyr Ala Arg lie Ala Ala Gly Phe Arg Asp Val Arg Asp Val 5380 5385 5390 Ser Val lie Pro Met Pro Gly Phe lie Ala Gly Glu Pro Leu Pro Ser 5395 5400 5405 Ala lie Glu Val Ala Val Arg Thr Gin Ala Glu Ala Val Leu Gin Glu 5410 5415 5420 Phe Ala Gly Gly Ser Phe Val Leu Val Gly His Ser Ser Gly Gly Trp 5425 5430 5435 5440 Leu Ala His Glu Val Ala Gly Glu Leu Glu Arg Arg Gly Val Val Pro 5445 5450 5455 Ala Gly Val Val Leu Leu Asp Thr Tyr lie Pro Gly Glu lie Thr Pro 5460 5465 5470 Arg Phe Ser Val Ala Met Ala His Arg Thr Tyr Glu Lys Leu Ala Thr 5475 5480 5485 Phe Thr Asp Met Gin Asp Val Gly lie Thr Ala Met Gly Gly Tyr Phe 5310 lie Leu Asp Gly Met Asp 5325 5490 5495 5500 Arg Met Phe Thr Glu Trp Thr Pro Thr Pro lie Gly Ala Pro Thr Leu 5505 5510 5515 5520 Phe Val Arg Thr Glu Asp Cys Val Ala Asp Pro Glu Gly Arg Pro Trp 5525 5530 5535 Thr Asp Asp Ser Trp Arg Pro Gly Trp Thr Leu Ala Asp Ala Thr Val 5540 5545 5550 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 磯 訂 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（）
Gin Val Pro Gly Asp His Phe Ser Met Met Asp Glu His Ala Gly Ser 5555 5560 5565 Thr Ala Gin Ala Val Ala Ser Trp Leu Asp Lys Leu Asn Gin Arg Thr 5570 5575 5580 Ala Arg Gin Arg 5585 (2)序列辨識號碼:7之資料： (i) 序列特徵： (A) 長度：275個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:7 Val Leu Pro Gly Gly Ala Pro Thr Ser Gin Gin Val Gly Gin Met Tyr 15 10 15 Asp Leu Val Thr Pro Leu Leu Asn Ser Val Ala Gly Gly Pro Cys Ala 20 25 30 工le His His Gly Tyr Trp Glu Asn Asp Gly Arg Ala Ser Trp Gin Gin 35 40 45 Ala Ala Asp Arg Leu Thr Asp Leu Val Ala Glu Arg Thr Val Leu Asp 50 55 60 Gly Gly Val Arg Leu Leu Asp Val Gly Cys Gly Thr Gly Gin Pro Ala 65 70 Leu Arg Val Ala Arg Asp Asn Ala lie Gin 85 90 Ser Gin Val Gin Val Ala lie Ala Ala Asp 100 105 Leu Ser His Arg Val Asp Phe Ser Cys Val Asp Ala Met Ser Leu Pro 115 120 125 -171 - 75 80 He ΊΊ ir Gly lie _ rhr Val 95 Cys Ala Arg Glu . Arg Gly 110 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 請 先 閱 讀 注
I A7 1237058 __B7 五、發明説明（）
Tyr Pro Asp Asn Ala Phe Asp Ala Ala Trp Ala Met Gin Ser Leu Leu 130 135 140
Glu Met Ser Glu Pro Asp Arg Ala lie Arg Glu lie Leu Arg Val Leu 145 150 155 160
Lys Pro Gly Gly lie Leu Gly Val Thr Glu Val Val Lys Arg Glu Ala 165 170 175
Gly Gly Gly Met Pro Val Ser Gly Asp Arg Trp Pro Thr Gly Leu Arg 180 185 190 工 le Cys Leu Ala Glu Gin Leu Leu Glu Ser Leu Arg Ala Ala Gly Phe 195 200 205
Glu lie Leu Asp Trp Glu Asp Val Ser Ser Arg Thr Arg Tyr Phe Met 210 215 220
Pro Gin Phe Ala Glu Glu Leu Ala Ala His Gin His Gly lie Ala Asp 225 230 235 240
Arg Tyr Gly Pro Ala Val Ala Gly Trp Ala Ala Ala Val Cys Asp Tyr 245 250 255
Glu Lys Tyr Ala His Asp Met Gly Tyr Ala lie Leu Thr Ala Arg Lys 260 265 270
Pro Val Gly 275 (2)序列辨識號碼:8之資料： (i) 序列特徵： (A) 長度：390個胺基酸 (B) 型式：胺基酸 (D)拓樸學··線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:8
Met Arg Val Leu Val Val Pro Leu Pro Tyr Pro Thr His Leu Met Ala 1 5 l〇 15 -172 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） I----m (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） Met Val Pro Leu Cys Trp Ala Leu Gin Ala Ser Gly His Glu Val Leu 20 25 30 lie Ala Ala Pro Pro Glu Leu Gin Ala Thr Ala His Gly Ala Gly Leu 35 40 45 Thr Thr Ala Gly lie Arg Gly Asn Asp Arg Thr Gly Asp Thr Gly Gly 50 55 60 Thr Thr Gin Leu Arg Phe Pro Asn Pro Ala Phe Gly Gin Arg Asp Thr 65 70 75 80 Glu Ala Gly Arg Gin Leu Trp Glu Gin Thr Ala Ser Asn Val Ala Gin 85 90 95 Ser Ser Leu Asp Gin Leu Pro Glu Tyr Leu Arg Leu Ala Glu Ala Trp 100 105 110 Arg Pro Ser Val Leu Leu Val Asp Val Cys Ala Leu lie Gly Arg Val 115 120 125 Leu Gly Gly Leu Leu Asp Leu Pro Val Val Leu His Arg Trp Gly Val 130 135 140 Asp Pro Thr Ala Gly Pro Phe Ser Asp Arg Ala His Glu Leu Leu Asp 145 150 155 160 Pro Val Cys Arg His His Gly Leu Thr Gly Leu Pro Thr Pro Glu Leu 165 170 175 工le Leu Asp Pro Cys Pro Pro Ser Leu Gin Ala Ser Asp Ala Pro Gin 180 185 190 Gly Ala Pro Val Gin Tyr Val Pro Tyr Asn Gly Ser Gly Ala Phe Pro 195 200 205 Ala Trp Gly Ala Ala Arg Thr Ser Ala Arg Arg Val Cys lie Cys Met 210 215 220 Gly Arg Met Val Leu Asn Ala Thr Gly Pro Ala Pro Leu Leu Arg Ala 225 230 235 240 Val Ala Ala Ala Thr Glu Leu Pro Gly Val Glu Ala Val lie Ala Val 245 250 255 Pro Pro Glu His Arg Ala Leu Leu Thr Asp Leu Pro Asp Asn Ala Arg -173 - .1— #11 (請先閲讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） 260 265 270 工 le Ala Glu Ser Val Pro Leu Asn Leu Phe Leu Arg Thr Cys Glu Leu 275 280 285 Val lie Cys Ala Gly Gly Ser Gly Thr Ala Phe Thr Ala Thr Arg Leu 290 295 300 Gly lie Pro Gin Leu Val Leu Pro Gin Tyr Phe Asp Gin Phe Asp Tyr 305 310 315 320 Ala Arg Asn Leu Ala Ala Ala Gly Ala Gly lie Cys Leu Pro Asp Glu 325 330 335 Gin Ala Gin Ser Asp His Glu Gin Phe Thr Asp Ser lie Ala Thr Val 340 345 350 Leu Gly Asp Thr Gly Phe Ala Ser Ala Ala lie Lys Leu Ser Asp Glu 355 360 365 工le Thr Ala Met Pro His Pro Ala Ala Leu Val Arg Thr Leu Glu Asn 370 375 380 Thr Ala Ala lie Arg Ala 385 390 (2)序列辨識號碼:9之資料： ①序列特徵： (A) 長度：250個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:9 Met Pro Ser Gin Asn Ala Leu Tyr Leu Asp Leu Leu Lys Lys Val Leu 1 5 10 15 Thr Asn Thr lie Tyr Ser Asp Arg Pro His Pro Asn Ala Trp Gin Asp 20 25 30 Asn Thr Asp Tyr Arg Gin Ala Ala Arg Ala Lys Gly Thr Asp Trp Pro (請先聞讀背面之注意事項再填寫本頁)
V 本紙張又度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（） 35 40 45
Thr Val Ala His Thr Met lie Gly Leu Glu Arg Leu Asp Asn Leu Gin 50 55 60
His Cys Val Glu Ala Val Leu Ala Asp Gly Val Pro Gly Asp Phe Ala 65 70 75 80
Glu Thr Gly Val Trp Arg Gly Gly Ala Cys lie Phe Met Arg Ala Val 85 90 95
Leu Gin Ala Phe Gly Asp Thr Gly Arg Thr Val Trp Val Val Asp Ser 100 105 110
Phe Gin Gly Met Pro Glu Ser Ser Ala Gin Asp His Gin Ala Asp Gin 115 120 125
Ala Met Ala Leu His Glu Tyr Asn Asp Val Leu Gly Val Ser Leu Glu 130 135 140
Thr Val Arg Gin Asn Phe Ala Arg Tyr Gly Leu Leu Ά 145 150
Arg Phe Leu Pro Gly Trp Phe 165 #1 (請先閲讀背面之注意事項再填寫本頁)
Glu Gin Val 160 Ala Pro lie 175 155 Asp Thr Leu Pro 170 訂
Gin Glu Leu Ala Val Leu Arg Leu Asp Gly Asp Leu Tyr Glu Ser Thr 180 185 190 Met Asp Ser Leu Arg Asn Leu Tyr Pro Lys Leu Ser Pro Gly Gly Phe 195 200 205 Val lie lie Asp Asp Tyr Phe Leu Pro Ser Cys Gin Asp Ala Val Lys 210 215 220 Gly Phe Arg Ala Glu Leu Gly lie Thr Glu Pro lie His Asp lie Asp 經濟部智慧財產局員工消費合作社印製 225 230 Gly Thr Gly Ala Tyr Trp Arg 245⑵序列辨識號碼:10之資料： (i)序列特徵：(A)長度：395個胺基酸
Ser 235 250 -175 - 240 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 1237058 A7 經濟部智慧財產局員工消費合作社印製 _B7五、發明説明（） (B)型式：胺基酸 (D)拓樸學：線形 (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:10 Met Ser Glu lie Ala Val Ala Pro Trp Ser Val Val Glu Arg Leu Leu 15 10 15 Leu Ala Ala Gly Ala Gly Pro Ala Lys Leu Gin Glu Ala Val Gin Val 20 25 30 Ala Gly Leu Asp Ala Val Ala Asp Ala lie Val Asp Glu Leu Val Val 35 40 45 Arg Cys Asp Pro Leu Ser Leu Asp Glu Ser Val Arg lie Gly Leu Glu 50 55 60 工le Thr Ser Gly Ala Gin Leu Val Arg Arg Thr Val Glu Leu Asp His 65 70 75 80 Ala Gly Leu Arg Leu Ala Ala Val Ala Glu Ala Ala Ala Val Leu Arg 85 90 95 Phe Asp Ala Val Asp Leu Leu Glu Gly Leu Phe Gly Pro Val Asp Gly 100 105 110 Arg Arg His Asn Ser Arg Glu Val Arg Trp Ser Asp Ser Met Thr Gin 115 120 125 Phe Ser Pro Asp Gin Gly Leu Ala Gly Ala Gin Arg Leu Leu Ala Phe 130 135 140 Arg Asn Arg Val Ser Thr Ala Val His Ala Val Leu Ala Ala Ala Ala 145 150 155 160 Thr Arg Arg Ala Asp Leu Gly Ala Leu Ala Val Arg Tyr Gly Ser Asp 165 170 175 Lys Trp Ala Asp Leu His Trp Tyr Thr Glu His Tyr Glu His His Phe 180 185 190 Ser Arg Phe Gin Asp Ala Pro Val Arg Val Leu Glu lie Gly lie Gly 195 200 205 -176 - (請先閲讀背面之注意事項再填寫本頁)
本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（) Gly Tyr His Ala Pro Glu Leu Gly Gly Ala Ser Leu Arg Met Trp Gin 210 215 220 Arg Tyr Phe Arg Arg Gly Leu Val Tyr Gly Leu Asp lie Phe Glu Lys 225 230 235 240 Ala Gly Asn Glu Gly His Arg Val Arg Lys Leu Arg Gly Asp Gin Ser 245 250 255 Asp Ala Glu Phe Leu Glu Asp Met Val Ala Lys lie Gly Pro Phe Asp 260 265 270 工le Val lie Asp Asp Gly Ser His Val Asn Asp His Val Lys Lys Ser 275 280 285 Phe Gin Ser Leu Phe Pro His Val Arg Pro Gly Gly Leu Tyr Val lie 290 295 300 Glu Asp Leu Gin Thr Ala Tyr Trp Pro Gly Tyr Gly Gly Arg Asp Gly 305 310 315 320 Glu Pro Ala Ala Gin Arg Thr Ser lie Asp Met Leu Lys Glu Leu lie 325 330 335 Asp Gly Leu His Tyr Gin Glu Arg Glu Ser Arg Cys Gly Thr Glu Pro 340 345 350 Ser Tyr Thr Glu Arg Asn Val Ala Ala Leu His Phe Tyr His Asn Leu 355 360 365 Val Phe Val Glu Lys Gly Leu Asn Ala Glu Thr Ala Ala Pro Gly Phe 370 375 380 Val Pro Arg Gin Ala Leu Gly Val Glu Gly Gly 385 390 395 (2)序列辨識號碼:11之資料：(i)序列特徵： (A) 長度：539個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (請先閲讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（ (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:11
Met lie Ser Ala Ala Gly Glu Gin Ser Gly Pro Val Arg Lys Gly Gly 15 10 15
Ala Val Pro Glu Phe His Asp Pro Ala Pro Met Asn Arg Arg Thr Pro 20 25 30
Gly Thr Glu lie Thr Val Glu Pro Asp Asp Pro Arg Tyr Pro Asp Leu 35 40 45
Val Val Gly His Asn Pro Arg Phe Thr Gly Lys Pro Glu Arg lie His 50 55 60 工le Ala Ser Ser Ala Glu Asp Val Val His Ala Val Ala Asp Ala Val 65 70 75 80
Arg Thr Gly Arg Arg Val Gly Val Arg Ser Gly Gly His Cys Phe Glu 85 90 95
Asn Leu Val Ala Asp Pro Ala lie Arg Val Leu Val Asp Leu Ser Glu 110
Gly Ala Phe Ala lie Glu 125
Thr Leu Phe Lys Asn Trp 140 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
、1T 100 105 Leu Asn Arg Val Tyr Tyr Asp Ser Thr 1 115 120 Ala Gly Ala Ala Leu Gly Gin Val Tyr 1 130 135 Gly Val Thr lie Pro Thr Gly Ala CyS pr。Gly Val Gly Ala Gly Gly 145 150 155 160 His lie Leu Gly Gly Gly Tyr Gly Pro Leu Ser Arg Arg Phe Gly Ser 165 170 175 Val Val Asp Tyr Leu Gin Gly Val Glu Val Val Val Val Asp Gin Ala 180 185 190 Gly Glu Val His lie Val Glu Ala Asp Arg Asn Ser Thr Gly Ala Gly 195 200 205 His Asp Leu Trp Trp Ala His Thr Gly Gly Gly Gly Gly Asn Phe Gly 210 215 220 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） lie Val Thr Arg Phe Trp Leu 225 230
Pro Asp Val Val Ser Thr Asp 235 240
Ala Ala Glu Leu Leu Pro Arg Pro Pro Ala Thr Val Leu Leu Arg Ser 245 250 255 Phe His Trp Pro Trp His Glu Leu Thr Glu Gin Ser Phe Ala Val Leu 260 265 270 Leu Gin Asn Phe Gly Asn Trp Tyr Glu Gin His Ser Ala Pro Glu Ser 275 280 285 Thr Gin Leu Gly Leu Phe Ser Thr Leu Val Cys Ala His Arg Gin Ala 290 295 300 Gly Tyr Val Thr Leu Asn Val His Leu Asp Gly Thr Asp Pro Asn Ala 305 310 315 320 Glu Arg Thr Leu Ala Glu His Leu Ser Ala lie Asn Ala Gin Val Gly 325 330 335 Val Thr Pro Ala Glu Gly Leu Arg Glu Thr Leu Pro Trp Leu Arg Ser 340 345 350 Thr Gin Val Ala Gly Ala lie Ala Glu Gly Gly Glu Pro Gly Met Gin 355 360 365 Arg Thr Lys Val Lys Ala Ala Tyr Leu Arg Thr Gly Leu Ser Glu Ala 370 375 380 Gin Leu Ala Thr Val Tyr Arg Arg Leu Thr Val Tyr Gly Tyr Asp Asn 385 390 395 400 Pro Ala Ala Ala Leu Leu Leu Leu Gly Tyr Gly Gly Met Ala Asn Ala 405 410 415 Val Ala Pro Ser Ala Thr Ala Leu Ala Gin Arg Asp Ser Val Leu Lys 420 425 430 Ala Leu Phe Val Thr Asn Trp Ser Glu Pro Ala Glu Asp Glu 1 440 445 j Gly Phe Tyr Arg Glu Met Tyr Ala Glu r 435 Leu Thr Trp lie 450 455 460
His
Gly
Gly Val Pro Val Pro Gly
Val Asp Gly Ser Tyr lie Asn Tyr (請先閲讀背面之注意事項再填寫本頁)
本紙張又度適用中國國家標準（CNS ) A4規格（2丨0、〆297公釐） lie lie Leu Ala 15 Thr Glu Leu Gly 30 經濟部智慧財產局員工消費合作社印製 1237058 A7 A7 B7 五、發明説明（ 465 470 475 480
Pro Asp Thr Asp Leu Ala Asp Pro Leu Trp Asn Thr Ser Gly Val Ala 485 490 495
Trp His Asp Leu Tyr Tyr Lys Asp Asn Tyr Pro Arg Leu Gin Arg Ala 500 505 510
Lys Ala Arg Trp Asp Pro Gin Asn lie Phe Gin His Gly Leu Ser lie 515 520 525
Lys Pro Pro Ala Arg Leu Ser Pro Gly Gin Pro 530 535 ⑵序列辨識號碼:12之資料： (i) 序列特徵： (A) 長度：397個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:12 Met Ser Thr Thr His Glu lie Glu Thr Val Glu J 15 10
Ala Gly Ser Ser Ala Ala Ser Leu Ala Asp Leu ： 20 25
Leu Ala Arg lie Ala Pro Val Leu lie Asp Glu lie Leu Phe Arg Ala 35 40 45
Glu Pro Ala Pro Asp lie Glu Arg Thr Glu Val Ala Val Gin lie Thr 50 55 60
His Arg Gly Glu Thr Val Asp Phe Val Leu Thr Leu Gin Ser Gly Glu 65 70 75 80
Leu lie Lys Ala Glu Gin Arg Pro Val Gly Asp Val Pro Leu Arg lie 85 90 95
Gly Tyr Glu Leu Thr Asp Deu lie Ala Glu Leu Phe Gly Pro Gly Ala -180 - 本紙張尺度適用中國國家標準（CNS ) Α4規格（21〇Χ297公釐） (請先閲讀背面之注意事項再填寫本頁)
、1T 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） 100 105 110
Pro Arg Ala Val Gly Ala Arg Ser Thr Asn Phe Leu Arg Thr Thr Thr 115 120 125
Ser Gly Ser lie Pro Gly Pro Ser Glu Leu Ser Asp Gly Phe Gin Ala 130 135 140 工le Ser Ala Val Val Ala Gly Cys Gly His Arg Arg Pro Asp Leu Asn 145 150 155 160
Leu Leu Ala Ser His Tyr Arg Thr Asp Lys Trp Gly Gly Leu His Trp 165 170 175
Phe Thr Pro Leu Tyr Glu Arg His Leu Gly Glu Phe Arg Asp Arg Pro 180 185 190
Val Arg lie Leu Glu lie Gly Val Gly Gly Tyr Asn Phe Asp Gly Gly 195 200 205
Gly Gly Glu Ser Leu Lys Met Trp Lys Arg Tyr Phe His Arg Gly Leu 210 215 220
Val Phe Gly Met Asp Val Phe Asp Lys Ser Phe Leu Asp Gin Gin Arg 225 230 235 240
Leu Cys Thr Val Arg Ala Asp Gin Ser Lys Pro Glu Glu Leu Ala Ala 245 250 255
Val Asp Asp Lys Tyr Gly Pro Phe Asp lie lie lie Asp Asp Gly Ser 260 265 270
His lie Asn Gly His Val Arg Thr Ser Leu Glu Thr Leu Phe Pro Arg 275 280 285
Leu Arg Ser Gly Gly Val Tyr Val lie Glu Asp Leu Trp Thr Thr Tyr 290 295 300
Ala Pro Gly Phe Gly Gly Gin Ala Gin Cys Pro Ala Ala Pro Gly Thr 305 310 315 320
Thr Val Ser Leu Leu Lys Asn Leu Leu Glu Gly Val Gin His Glu Glu 325 330 335
Gin Pro His Ala Gly Ser Tyr Glu Pro Ser Tyr Leu Glu Arg Asn Leu 340 345 350 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） Val Gly Leu His Thr Tyr His Asn lie Ala Phe Leu Glu Lys Gly Val 355 360 365 Asn Ala Glu Gly Gly Val Pro Ala Tip Val Pro Arg Ser Leu Asp Asp 370 375 380 工le Leu His Leu Ala Asp Val Asn Ser Ala Glu Asp Glu 385 390 395 (2)序列辨識號碼:13之資料：(i) 序列特徵： (A) 長度：283個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:13 Val Glu Ser lie Phe Asp Ala Leu Ala His Gly Arg Pro Leu His His 15 10 15 Gly Tyr Trp Ala Gly Gly Tyr Arg Glu Asp Ala Gly Ala Thr Pro Trp 20 25 30 Ser Asp Ala Ala Asp Gin Leu Thr Asp Leu Phe lie Asp Lys Ala Ala 35 40 45 Leu Arg Pro Gly Ala His Leu Phe Asp Leu Gly Cys Gly Asn Gly Gin 50 55 60 Pro Val Val Arg Ala Ala Cys Ala Ser Gly Val Arg Val Thr Gly lie 65 70 75 80 Thr Val Asn Ala Gin His Leu Ala Ala Ala Thr Arg Leu Ala Asn Glu 85 90 95 Thr Gly Leu Ala Gly Ser Leu Glu Phe Asp Leu Val Asp Gly Ala Gin 100 105 110 Leu Pro Tyr Pro Asp Gly Phe Phe Gin Ala Ala Trp Ala Met Gin Ser 115 120 125 (請先閲讀背面之注意事項再填寫本頁)
、1T 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） Val Val Gin lie Val Asp Gin Ala Ala Ala lie Arg Glu Val His Arg 130 135 140 工le Leu Glu Pro Gly Gly Arg Phe Val Leu Gly Asp lie lie Thr Arg 145 150 155 160 _ Val Arg Leu Pro Glu Glu Tyr Ala Ala Val Trp Thr Gly Thr Thr Ala 165 170 175 His Thr Leu Asn Ser Phe Thr Ala Leu Val Ser Glu Ala Gly Phe Glu 180 185 190 lie Leu Glu Val Thr Asp Leu Thr Ala Gin Thr Arg Cys Met Val Ser 195 200 205 Trp Tyr Val Asp Glu Leu Leu Arg Lys Leu Asp Glu Leu Ala Gly Val 210 215 220 Glu Pro Ala Ala Val Gly Thr Tyr Gin Gin Arg Tyr Leu Gly Asp lie 225 230 235 240 Ala Ala Lys His Gly Pro Gly Pro Ala Gin Leu lie Ala Ala Val Ala 245 250 255 Glu Tyr Arg Lys His Pro Asp Tyr Ala Arg Asn Glu Glu Ser Met Gly 260 265 270 Phe Met Leu Leu Gin Ala Arg Lys Lys Gin Ser 275 280 (2)序列辨識號碼:14之資料： (i) 序列特徵： (A) 長度：320個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:14 Met Pro Asn Ala Val Ser Gly Thr Val Leu Val Pro Asn lie Pro Trp 1 5 10 15 ---------- (請先閱讀背面之注意事項再填寫本買) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 A7 B7 五、發明説明（ 經濟部智慧財產局員工消費合作社印製
Pro Arg Glu Asp Arg Pro lie lie Thr Phe Ala Val Gly Thr His Gly 20 25 30 Leu Gly Ser Gin Val Ala Pro Ser Tyr Leu Leu Arg Thr Gly Thr Glu 35 40 45 Pro Glu Thr Glu Leu lie Ala Val Ala Leu Asp Arg Gly Trp Ala Val 50 55 60 Val lie Thr Asp Tyr Glu Gly Leu Gly Thr Pro Gly Thr His Thr Tyr 65 70 75 80 Thr Val Gly Arg Ala Gin Gly His Ala Met Leu Asp Ala Ala Arg Ala 85 90 95 Ala Gin Arg Leu Pro Gly Ser Gly Leu Thr Thr Asp Cys Pro Val Gly 100 105 110 lie Trp Gly Tyr Ala Gin Gly Gly Gin Ala Ser Ala Phe Ala Gly Glu 115 120 125 Leu His Pro Thr Tyr Ala Pro Glu Leu Arg lie Arg Ala Ala Ala Ala 130 135 140 Gly Ala Val Pro lie Asp Leu Leu Asp lie lie His Arg Asn Asp Gly 145 150 155 160 Val Phe Thr Gly Pro Val Leu Ala Gly Leu Val Gly His Ala Ala Ala 165 170 175 Tyr Pro Asp Leu Pro Phe Asp Glu Leu Leu Thr Glu Ala Gly Arg Thr 180 185 190 Ala Val Asp Gin Val Arg Glu Leu Gly Ala Pro Glu Leu Val Thr Arg 195 200 205 Phe Leu Gly Arg Glu Leu Ser Asp Phe Leu Asp Thr Ser Gly Leu Phe 210 215 Glu Gin Pro Arg Trp Arg Ala 225 230 Asn Gly Gly Pro Val Val Pro 245 220 Leu Ala Glu Ser Val Ala Gly Arg 235 240 Leu Val Tyr His Ser Thr Asp Asp 250 . 255
Glu lie Val Pro Phe Ala Phe Gly Glu Arg Leu Arg Asp Ser Tyr Arg 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 舞丨 (請先閲讀背面之注意事項再填寫本頁) 1237058 Λ7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） 260 265 270 Ala Ala Gly Thr Pro Val Arg Trp His Pro Leu Ser Gly Leu Ala His 275 280 285 Phe Pro Ala Ala Leu Ala Ser Ser Arg Val Val Val Ser Trp Phe Asp 290 295 300 Glu His Phe Ser Glu Pro Ser Ala lie Ser Gly Pro Arg Asp Ala Arg 305 310 315 320 (2)序列辨識號碼:15之資料： ①序列特徵： (A) 長度：332個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:15 Met Arg Lys Pro Val Arg lie Gly Val Leu Gly Cys Ala Ser Phe Ala 15 10 15 Trp Arg Arg Met Leu Pro Ala Met Cys Asp Val Ala Glu Thr Glu Val 20 25 30 Val Ala Val Ala Ser Arg Asp Pro Ala Lys Ala Glu Arg Phe Ala Ala 35 40 45 Arg Phe Glu Cys Glu Ala Val Leu Gly Tyr Gin Arg Leu Leu Glu Arg 50 55 60 Pro Asp lie Asp Ala Val Tyr Val Pro Leu Pro Pro Gly Met His Ala 65 70 75 80 Glu Trp lie Gly Lys Ala Leu Glu Ala Asp Lys His Val Leu Ala Glu 85 90 95 Lys Pro Leu Thr Thr Thr Ala Ser Asp Thr Ala Arg Leu Val Gly Leu 100 105 110 Ala Arg Arg Lys Asn Leu Leu Leu Arg Glu Asn Tyr Leu Phe Leu His (請先閲讀背面之注意事項再填寫本頁) 本纸張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） 115 120 125 His Gly Arg His Asp Val Val Arg Asp Leu Leu Gin Ser Gly Glu lie 130 135 140 Gly Glu Leu Arg Glu Phe Thr Ala Val Phe Gly lie Pro Pro Leu Pro 145 150 155 160 Asp Thr Asp lie Arg Tyr Arg Thr Glu Leu Gly Gly Gly Ala Leu Leu 165 170 175 Asp lie Gly Val Tyr Pro Ala Arg Ala Ala Arg His Phe Leu Leu Gly 180 185 190 Pro Leu Thr Val Leu Gly Ala Ser Ser His Glu Ala Gin Glu Ser Gly 195 200 205 Val Asp Leu Ser Gly Ser Val Leu Leu Gin Ser Glu Gly Gly Thr Val 210 215 220 Ala His Leu Gly Tyr Gly Phe Val His His Tyr Arg Ser Ala Tyr Glu 225 230 235 240 Leu Trp Gly Ser Arg Gly Arg lie Val Val Asp Arg Ala Phe Thr Pro 245 250 255 Pro Ala Glu Trp Gin Ala Val lie Arg lie Glu Arg Lys Gly Val Val 260 265 270 Asp Glu Leu Ser Leu Pro Ala Glu Asp Gin Val Arg Lys Ala Val Thr 275 280 285 Ala Phe Ala Arg Asp lie Arg Ala Gly Thr Gly Val Asp Asp Pro Ala 290 295 300 Val Ala Gly Asp Ser Gly Glu Ser Met lie Gin Gin Ala Ala Leu Val 305 310 315 320 Glu Ala lie Gly Gin Ala Arg Arg Cys Gly Ser Thr 325 330 (2)序列辨識號碼:16之資料： ①序列特徵： (A)長度：486個胺基酸 (請先閲讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) a4規格（21〇X297公釐） A7 經濟部智慧財產局員工消費合作社印製 1237058 B7 五、發明説明（） (B)型式：胺基酸 (D)拓樸學：線形 (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:16
Met Ser Ser Ser Val Glu Ala Glu Ala Ser Ala Ala Ala Pro Leu Gly 15 10 15
Ser Asn Asn Thr Arg Arg Phe Val Asp Ser Ala Leu Ser Ala Cys Asn 20 25 30
Gly Met lie Pro Thr Thr Glu Phe His Cys Trp Leu Ala Asp Arg Leu 35 40 45
Gly Glu Asn Ser Phe Glu Thr Asn Arg lie Pro Phe Asp Arg Leu Ser 50 55 60
Lys Trp Lys Phe Asp Ala Ser Thr Glu Asn Leu Val His Ala Asp Gly 65 70 75 80
Arg Phe Phe Thr Val Glu Gly Leu Gin Val Glu Thr Asn Tyr Gly Ala 85 90 95
Ala Pro Ser Trp His Gin Pro lie 工le Asn Gin Ala Glu Val Gly lie 100 105 110
Leu Gly lie Leu Val Lys Glu lie Asp Gly Val Leu His Cys Leu Met 115 120 125
Ser Ala Lys Met Glu Pro Gly Asn Val Asn Val Leu Gin Leu Ser Pro 130 135 140
Thr Val Gin Ala Thr Arg Ser Asn Tyr Thr Gin Ala His Arg Gly Ser 145 150 155 160
Val Pro Pro Tyr Val Asp Tyr Phe Leu Gly Arg Gly Arg Gly Arg Val 165 170 175
Leu Val Asp Val Leu Gin Ser Glu Gin Gly Ser Trp Phe Tyr Arg Lys 180 185 190
Arg Asn Arg Asn Met Val Val Glu Val Gin Glu Glu Val Pro Val Leu 195 200 205 -187 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） Pro Asp Phe Cys Trp Leu Thr Leu Gly Gin Val Leu Ala Leu Leu Arg 210 215 220 Gin Asp Asn lie Val Asn Met Asp Thr Arg Thr Val Leu Ser Cys lie 225 230 235 240 Pro Phe His Asp Ser Ala Thr Gly Pro Glu Leu Ala Ala Ser Glu Glu 245 250 255 Pro Phe Arg Gin Ala Val Ala Arg Ser Leu Ser His Gly lie Asp Ser 260 265 270 Ser Ser lie Ser Glu Ala Val Gly Trp Phe Glu Glu Ala Lys Ala Arg 275 280 285 Tyr Arg Leu Arg Ala Thr Arg Val Pro Leu Ser Arg Val Asp Lys Trp 290 295 300 Tyr Arg Thr Asp Thr Glu lie Ala His Gin Asp Gly Lys Tyr Phe Ala 305 310 315 320 Val 工le Ala Val Ser Val Ser Ala Thr Asn Arg Glu Val Ala Ser Trp 325 330 335 Thr Gin Pro Met lie Glu Pro Arg Glu Gin Gly Glu lie Ala Leu Leu 340 345 350 Val Lys Arg lie Gly Gly Val Leu His Gly Leu Val His Ala Arg Val 355 360 365 Glu Ala Gly Tyr Lys Trp Thr Ala Glu lie Ala Pro Thr Val Gin Cys 370 375 380 Ser Val Ala Asn Tyr Gin Ser Thr Pro Ser Asn Asp Trp Pro Pro Phe 385 390 395 400 Leu Asp Asp Val Leu Thr Ala Asp Pro Glu Thr Val Arg Tyr Glu Ser 405 410 415 工le Leu Ser Glu Glu Gly Gly Arg Phe Tyr Gin Ala Gin Asn Arg Tyr 420 425 430 Arg lie lie Glu Val His Glu Asp Phe Ala Ala Arg Pro Pro Ser Asp 435 440 445 Phe Arg Trp Met Thr Leu Gly Gin Leu Gly Glu Leu Leu Arg Ser Thr • 188 - (請先閲讀背面之注意事項再填寫本頁) 訂 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 450 455 460
His Phe Leu Asn lie Gin Ala Arg Ser Leu Val Ala Ser Leu His Ser 465 470 475 480
Leu Trp Ala Leu Gly Arg 485 (2)序列辨識號碼:17之資料： (i) 序列特徵： (A) 長度：455個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:17
Val lie Leu Gly Met Leu Pro Gly Cys Ser lie Ala lie Gly Glu Phe 15 10 15
Met Arg Val Leu Phe Thr Pro Leu Pro Ala Ser Ser His Phe Phe Asn 20 25 30
Leu Val Pro Leu Ala Trp Ala Leu Arg Ala Ala Gly His Glu Val Arg 35 40 45
Val Ala lie Cys Pro Asn Met Val Ser Met Val Thr Gly Ala Gly Leu 50 55 60
Thr Ala Val Pro Val Gly Asp Glu Leu Asp Leu lie Ser Leu Ala Ala 65 70 75 80
Lys Asn Glu Leu Val Leu Gly Ser Gly Val Ser Phe Asp Glu Lys Gly 85 90 95
Arg His Pro Glu Leu Phe Asp Glu Leu Leu Ser lie Asn Ser Gly Arg 100 105 110
Asp Thr Asp Ala Val Glu Gin Leu His Leu Val Asp Asp Arg Ser Leu 115 120 125
Asp Asp Leu Met Gly Phe Ala Glu Lys Trp Gin Pro Asp Leu Val Val 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閲讀背面之注意事項再填寫本頁)
1237058 Λ7 B7 五、發明説明（） 130 135 140
Trp Asp Ala Met Val Cys Ser Gly Pro Val Val Ala Arg Ala Leu Gly 145 150 155 160
Ala Arg His Val Arg Met Leu Val Ala Leu Asp Val Ser Gly Trp Leu 165 170 175
Arg Ser Gly Phe Leu Glu Tyr Gin Glu Ser Lys Pro Pro Glu Gin Arg 180 185 190
Val Asp Pro Leu Gly Thr Trp Leu Gly Ala Lys Leu Ala Lys Phe Gly 195 200 205
Ala Thr Phe Asp Glu Glu 工le Val Thr Gly Gin Ala Thr lie Asp Pro 210 215 220 工le Pro Ser Trp Met Arg Leu Pro Val Asp Leu Asp Tyr lie Ser Met 225 230 235 240
Arg Phe Val Pro Tyr Asn Gly Pro Ala Val Leu Pro Glu Trp Leu Arg 245 250 255
Glu Arg Pro Thr Lys Pro Arg Val Cys lie Thr Arg Gly Leu Thr Lys 260 265 270
Arg Arg Leu Ser Arg Val Thr Glu Gin Tyr Gly Glu Gin Ser Asp Gin 275 280 285
Glu Gin Ala Met Val Glu Arg Leu Leu Arg Gly Ala Ala Arg Leu Asp 290 295 300
Val Glu Val 工le Ala Thr Leu Ser Asp Asp Glu Val Arg Glu Met Gly 305 310 315 320
Glu Leu Pro Ser Asn Val Arg Val His Glu Tyr Val Pro Leu Asn Glu 325 330 335
Leu Leu Glu Ser Cys Ser Val lie lie His His Gly Ser Thr Thr Thr 340 345 350
Gin Glu Thr Ala Thr Val Asn Gly Val Pro Gin Leu lie Leu Pro Gly 355 360 365
Thr Phe Trp Asp Glu Ser Arg Arg Ala Glu Leu Leu Ala Asp Arg Gly 370 375 380 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 、?! 經濟部智慧財產局員工消費合作社印製 1237058 Λ7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（）
Ala Gly Leu Val Leu Asp Pro Ala Thr Phe Thr Glu Asp Asp Val Arg 385 390 395 400 Gly Gin Leu Ala Arg Leu Leu Asp Glu Pro Ser Phe Ala Ala Asn Ala 405 410 415 Ala Leu lie Arg Arg Glu lie Glu Glu Ser Pro Ser Pro His Asp lie 420 425 Val Pro Arg Leu Glu Lys Leu Val Ala Glu 435 440 Gly Gin Ser Asp Gly His Pro 450 455 (2)序列辨識號碼:18之資料·· (i) 序列特徵： (A) 長度：462個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:18
Met Gin Ser Arg Lys 1 5 Thr Ser Cys Asp Asp 20 430
Glu Asn 445
Ala Leu Gly Lys Gly Arg Ala
Val 0! (請先閲讀背面之注意事項再填寫本頁)
、1T 10 15
Glu Met Val Pro Asp 30 Tyr His Arg Glu Gin 45 p Thr Cys Ala Thr Ala r 25 Ala Lys Asp Arg lie Leu Ala Ser Val Arg j 35 40 Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro lie Arg Pro Ser Gly 50 55 60 Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu 65 70 75 80 Glu Leu Arg lie Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu 85 90 95 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 1237058 A7 B7 經濟智慧財產局員工消費合作社印製 五、發明説明（）
Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly 100 105 110 Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu 115 120 125 Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val lie Thr Ala Ala Val 130 135 140 Gly Phe Pro Thr Thr lie Asn Pro Ala Val Gin Asn Gly Leu Val Pro 145 150 155 160 Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg 165 170 175 工le Lys Ala Ala Val Thr Glu Arg Thr Arg Ala lie Met Leu Ala His 180 185 190 Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu lie Ala Glu lie Ala Lys 195 200 205 Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 210 215 220 Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu 225 230 Ser Phe Tyr Pro Ala His His lie 〔 245 ' Thr Val 235 240 Ser Gly Glu Gly Gly Cys Val 250 255
Leu Thr Gly Ser Leu Glu Leu Ala Arg lie lie Glu Ser Leu Arg Asp 260 265 270 Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg 275 280 285 Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His 290 295 300 Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu 305 310 315 320 Gin Ala Ala Leu Ala Leu Ser Gin Leu Ser Lys lie Ser Ala Phe Gly 325 330 335 Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（) 340 345 350
Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser 355 360 365
Trp Phe Gly Phe Ala lie Thr lie Ser Ala Asp Ala Gly Phe Thr Arg 370 375 380
Ala Ala Leu V&1 Asn Phe Leu Glu Ser Arg Asn lie Gly Thr Arg Leu 385 390 395 400
Leu Phe Gly Gly Asn lie Thr Arg His Pro Ala Phe Glu Gin Val Arg 405 410 415
Tyr Arg lie Ala Asp Ala Leu Thr Asn Ser Asp lie Val Thr Asp Arg 420 425 430
Thr Phe Trp Val Gly Val Tyr Pro Gly lie Thr Asp Gin Met lie Asp 435 440 445
Tyr Val Val Glu Ser lie Ala Glu Phe Val Ala Lys Ser Ser 450 455 460 (2)序列辨識號碼:19之資料： ①序列特徵： (A) 長度：385個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:19
Val lie Asn Leu His Gin Pro lie Leu Gly Thr Glu Glu Leu Asp Ala 15 10 15 工le Ala Glu Val Phe Ala Ser Asn Trp lie Gly Leu Gly Pro Arg Thr 20 25 30
Arg Thr Phe Glu Ala Glu Phe Ala His His Leu Gly Val Asp Pro Glu 35 40 45
Gin Val Val Phe Leu Asn Ser Gly Thr Ala Ala Leu Phe Leu Thr Val -193 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閱讀背面之注意事項再填寫本頁)
1237058 Λ7 B7 五、發明説明（） 50 55 60
Gin Val Leu Asp Leu Gly Pro Gly Asp Asp Val Val Leu Pro Ser lie 65 70 75 80
Ser Phe Val Ala Ala Ala Asn Ala lie Ala Ser Ser Gly Ala Arg Pro 85 90 95
Val Phe Cys Asp Val Asp Pro Arg Thr Leu Asn Pro Thr Leu Asp Asp 100 105 110
Val Ala Arg Ala lie Thr Pro Ala Thr Lys Ala Val Leu Leu Leu His 115 120 125
Tyr Gly Gly Ser Pro Gly Glu Val Thr Ala lie Ala Asp Phe Cys Arg 130 135 140
Glu Lys Gly Leu Met Leu lie Glu Asp Ser Ala Cys Ala Val Ala Ser 145 150 155 160
Ser Val His Gly Thr Ala Cys Gly Thr Phe Gly Asp Leu Ala Thr Trp 165 170 175
Ser Phe Asp Ala Met Lys lie Leu Val Thr Gly Asp Gly Gly Met Phe 180 185 190
Tyr Ala Ala Asp Pro Glu Leu Ala His Arg Ala Arg Arg Leu Ala Tyr 195 200 205
His Gly Leu Glu Gin Met Ser Gly Phe Asp Ser Ala Lys Ser Ser Asn 210 215 220
Arg Trp Trp Asp lie Arg Val Glu Asp lie Gly Gin Arg Leu lie Gly 225 230 235 240
Asn Asp Met Thr Ala Ala Leu Gly Ser Val Gin Leu Arg Lys Leu Pro 245 250 255
Glu Phe lie Asn Arg Arg Arg Glu lie Ala Thr Gin Tyr Asp Arg Leu 260 265 270
Leu Ser Asp Val Pro Gly Val Leu Leu Pro Pro Thr Leu Pro Asp Gly 275 280 285
His Val Ser Ser His Tyr Phe Tyr Trp Val Gin Leu Ala Pro Glu lie 290 295 300 -194 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) •^91. 、訂 經濟部智慧財產局員工消費合作社印製 1237058 Λ7 B7 五、發明説明（）
Arg Asp Gin Val Ala Gin Gin Met Leu Glu Arg Gly lie Tyr Thr Ser 305 310 315 320
Tyr Arg Tyr Pro Pro Leu His Lys Val Pro lie Tyr Arg Ala Asp Cys 325 330 335
Lys Leu Pro Ser Ala Glu Asp Ala Cys Arg Arg Thr Leu Leu Leu Pro 340 345 350
Leu His Pro Ser Leu Asp Asp Ala Glu Val Arg Thr Val Ala Asp Glu 355 360 365
Phe Gin Lys Ala Val Glu His His lie Ser Gin Arg Ser Pro Leu Arg 370 375 380
Lys 385 (2)序列辨識號碼:20之資料： (i) 序列特徵： (A) 長度：249個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:20
Met Ser Arg Val Ser Asp Thr Phe Ala Glu Thr Ser Ser Val Tyr Ser 15 10 15
Pro Asp His Ala Asp lie Tyr Asp Ala lie His Ser Ala Arg Gly Arg 20 25 30
Asp Trp Ala Ala Glu Ala Gly Glu Val Val Gin Leu Val Arg Thr Arg 35 40 45
Leu Pro Glu Ala Gin Ser Leu Leu Asp Val Ala Cys Gly Thr Gly Ala 50 55 60
His Leu Glu Arg Phe Arg Ala Glu Tyr Ala Lys Val Ala Gly Leu Glu 65 70 75 80 本紙張尺度適用中國國家標準（CNS ) A4規格（210X：Z97公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製
Val Pro Glu Val 95 175 Ser Arg Met Thr 190 Asp Phe Thr Glu 205 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（
Leu Ser Asp Ala Met Arg Glu lie Ala lie Arg ί 85 90
Pro lie His lie Gly Asp lie Arg Asp Phe Asp Leu Gly Glu Pro Phe 100 105 110
Asp Val lie Thr Cys Leu Cys Phe Thr Ala Ala Tyr Met Arg Thr Val 115 120 125
Asp Asp Leu Arg Arg Val Thr Arg Asn Met Ala Arg His Leu Ala Pro 130 135 140
Gly Gly Val Ala Val lie Glu Pro Trp Trp Phe Pro Asp Lys Phe lie 145 150 155 160
Asp Gly Phe Val Thr Gly Ala Val Ala His His Gly Glu Arg Val lie 165 170
Ser Arg Leu Ser His Ser Val Leu Glu Gly Arg r 180 185
Val Arg Tyr Thr Val Ala Glu Pro Thr Gly lie J 195 200
Phe Glu lie Leu Ser Leu Phe Thr Glu Asp Glu Tyr Thr Ala Ala Leu 210 215 220
Glu Asp Ala Gly lie Arg Ala Glu Tyr Leu Pro Gly Ala Pro Asn Gly 225 230 235 240
Arg Gly Leu Phe Val Gly lie Arg Asn 245 (2)序列辨識號碼:21之資料： (i) 序列特徵： (A) 長度：255個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式··蛋白質 (xi)序列敘述：序列辨識編號:21 本紙張尺度適用中國國家標準（CNS ) Α4規格（21〇X297公釐） 舞— (請先閱讀背面之注意事項再填寫本頁) 、?τ 1237058 at B7 五、發明説明（）
Met Val Leu Val Pro Arg Arg Phe Arg Ala Thr Leu Glu Ser Met Ser 15 10 15
Glu Gin Thr lie Ala Leu Val Thr Gly Ala Asn Lys Gly lie Gly Tyr 20 25 30
Glu lie Ala Ala Gly Leu Gly Ala Leu Gly Trp Ser Val Gly lie Gly 35 40 45
Ala Arg Asp His Gin Arg Gly Glu Asp Ala Val Ala Lys Leu Arg Ala 50 55 60
Asp Gly Val Asp Ala Phe Ala Val Ser Leu Asp Val Thr Asp Asp Ala 65 70 75 80
Ser Val Ala Ala Ala Ala Ala Leu Leu Glu Glu Arg Ala Gly Arg Leu 85 90 95
Asp Val Leu Val Asn Asn Ala Gly lie Ala Gly Ala Trp Pro Glu Glu 100 105 110
Pro Ser Thr Val Thr Pro Ala Ser Leu Arg Ala Val Val Glu Thr Asn 115 120 125
Val 工 le Gly Val Val Arg Val Thr Asn Ala Met Leu Pro Leu Leu Arg 130 135 140
Arg Ser Glu Arg Pro Arg lie Val Asn Gin Ser Ser His Val Ala Ser 145 150 155 160
Leu Thr Leu Gin Thr Thr Pro Gly Val Asp Leu Gly Gly lie Ser Gly 165 170 175
Ala Tyr Ser Pro Ser Lys Thr Phe Leu Asn Ala lie Thr lie Gin Tyr 180 185 190
Ala Lys Glu Leu Ser Asp Thr Asn lie Lys 工le Asn Asn Ala Cys Pro 195 200 205
Gly Tyr Val Ala Thr Asp Leu Asn Gly Phe His Gly Thr Ser Thr Pro 210 215 220
Ala Asp Gly Ala Arg lie Ala lie Arg Leu Ala Thr Leu Pro Asp Asp 225 230 235 240
Gly Pro Thr Gly Gly Met Phe Asp Asp Ala Gly Asn Val Pro Trp 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） 245 250 255 (2)序列辨識號碼:22之資料： ①序列特徵： (A) 長度：278個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:22
Met Glu Thr Arg Glu Leu Arg Tyr Phe Val Ala Val Ala Glu Glu Leu 1 5 10 15
His Phe Gly Arg Ala Ala Gin Arg Leu Gly lie Ala Gin Pro Pro Leu 20 25 30
Ser Arg Thr lie Ala Gin Leu Glu Gin Arg Leu Gly Val Val Leu Leu 35 40 45
Gin Arg Thr Ser Arg Lys Val Ser Leu Tlir Glu Ala Gly Ala Met Leu 50 55 60
Leu Thr Glu Gly Arg Ala lie Leu Gly Ala Leu Ala Ala Ala Glu Arg 65 70 75 80
Arg Thr Gin Arg Ala Ala Thr Ser Gin Pro Ser Leu Val Leu Ala Ala 85 90 95
Lys Ala Gly Ala Ser Gly Glu Leu Leu Ala Lys Leu Leu Asp Ala Tyr 100 105 110
Ala Ala Glu Pro Gly Ala Val Ala Val Asp Leu Leu Leu Cys Glu Ser 115 120 125
Gin Pro Gin Lys Thr Leu His Asp Gly Arg Ala Asp Val Ala Leu Leu 130 135 140
His Gin Pro Phe Asp Pro Thr Ala Glu Leu Asp lie Glu lie Leu Asn 145 150 155 160
Thr Glu Gin Gin Val Ala lie Leu Pro Thr Ser His Pro Leu Ala Ser -198 - 一 - ---- ------- - _ --------------- 丨丨丨· 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先閲讀背面之注意事項再填寫本頁)
、1T 經濟部智慧財產局員工消費合作社印製 255 Ala Leu Ala Gly Leu Val 270 1237058 at B7 五、發明説明（） 165 170 175
Glu Pro His Val Arg Met Ala Asp Val Ser Ser Leu Pro Asp Leu Pro 180 185 190
Leu Ala Arg Trp Pro Gly Pro Asp Gly Val Tyr Pro Asp Gly Pro Gly 195 200 205
Val Glu Val Arg Asn Gin Thr Gin Leu Phe Gin Met lie Ala Leu Gly 210 215 220
Arg Thr Thr Val Val Met Pro Glu Ser Ser Arg Val Asn Leu Leu Glu 225 230 235 240
Gly Leu Ala Ala Val Pro Val Leu Asp Ala Pro Asp Val Thr Thr Val 245 250 工le Ala Trp Pro Pro His Ser Arg Ser j 260 265
Arg Val Ala Thr Leu Leu 275 (2)序列辨識號碼:23之資料： (i) 序列特徵： (A) 長度：198個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:23
Met Met Leu Lys Arg His Arg Leu Thr Thr Ala lie Thr Gly Leu Leu 15 10 15
Gly Gly Val Leu Leu Val Ser Gly Cys Gly Thr Ala Ala Ala Leu Gin 20 25 30
Ser Ser Pro Ala Pro Gly His Asp Ala Arg Asn Val Gly Met Ala Ser 35 40 45
Gly Gly Gly Gly Gly Asp lie Gly Thr Ser Asn Cys Ser Glu Ala Asp 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（) 50 55 60
Phe Leu Ala Thr Ala Thr Pro Val Lys Gly Asp Pro Gly Ser Phe lie 65 70 75 80
Val Ala Tyr Gly Asn Arg Ser Asp Lys Thr Cys Thr lie Asn Gly Gly 85 90 95
Val Pro Asn Leu Lys Gly Val Asp Met Ser Asn Ser Pro lie Glu Asp 100 105 110
Leu Pro Val Glu Asp Val Arg Leu Pro Asp Ala Pro Lys Glu Phe Thr 115 120 125
Leu Gin Pro Gly Gin Ser Ala Tyr Ala Gly lie Gly Met Val Leu Ala 130 135 140
Asp Ser Gly Asp Pro Asn Ala His Val Leu Thr Gly Phe Gin Ser Ser 145 150 155 160
Leu Pro Asp Met Ser Glu Ala Gin Pro Val Asn Val Leu Gly Asp Gly 165 170 175
Asn Val Lys Phe Ala Ala Lys Tyr Leu Arg Val Ser Ser Leu Val Ser 舞— (請先閱讀背面之注意事項再填寫本頁) -訂 經濟部智慧財產局員工消費合作社印製 180 185 Thr Ala Asp Glu Leu Arg 195 (2)序列辨識號碼:24之資料： (i) 序列特徵： (A) 長度：751個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:24 Val Leu Ser Val Glu Lys Gly Arg Glu Ser Ala 1 5 10 190
Trp Thr Ala Val 15
Leu Glu Gly Thr Leu Glu Arg lie Thr Phe Ala Asn Glu Glu Ser Gly 、紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（） 20 25 30
Tyr Thr Val Ala Arg lie Asp Thr Gly Arg Gly Gly Asp Leu Val Thr 35 40 45
Val Val Gly Ala Leu Leu Gly Ala Gin Pro Gly Glu Ala Leu Arg Met 50 55 60
Arg Gly Arg Trp Gly Ser His Pro Gin Tyr Gly Arg Gin Phe His Val 65 70 75 80
Asp Asp Tyr Thr Thr Val Leu Pro Ala Thr Val Gin Gly lie Arg Arg 85 90 95
Tyr Leu Gly Ser Gly Leu lie Lys Gly lie Gly Pro Lys Leu Ala Glu 100 105 110
Lys lie Val Asp His Phe Gly Val Ala Ala Leu Asp Val lie Glu Gin 115 120 125
Glu Pro Ala Arg Leu lie Glu Val Pro Lys Leu Gly Pro Lys Arg Thr 130 135 140
Lys Leu lie Ala Asp Ala Trp Glu Glu Gin Lys Ala lie Lys Glu Val 145 150 155 160
Met lie Phe Leu Gin Gly Val Gly Val Ser Thr Ser Leu Ala Val Lys 165 170 175 工le Tyr Lys Gin Tyr His Asp Asp Ala lie Arg Thr Val Lys Glu Glu 180 185 190
Pro Tyr Arg Leu Ala Gly Asp Val Trp Gly lie Gly Phe Lys Thr Ala 195 200 205
Asp Thr lie Ala Lys Ala Val Gly lie Pro His Asp Ser Pro Gin Arg 210 215 220
Val Lys Ala Gly Leu Gin Phe Thr Leu Ser Glu Ser Thr Gly Asp Gly 225 230 235 240
Asn Cys Tyr Leu Pro Glu Asn Glu Leu lie Ala Glu Ala Val Lys lie 245 250 255
Leu Ala Val Asp Thr Gly Leu Val lie Glu Cys Leu Ala Glu Leu Val 260 265 270 本紙張尺度適用中國國家標準（CNS ) A4規格（2Η)Χ297公釐） #.1 (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（）
Thr Glu Glu Gly Val Val Arg Glu Glu He Pro Thr Asp Asp Asp Glu 275 280 285
Val Pro Thr Val Ala lie Tyr Leu Val Pro Phe His Arg Ala Glu Val 290 295 300
Ala Leu Ala Asn Gin Leu Ser Arg Leu Leu Asn Thr Ser Ala Asp Arg 305 310 315 320
Met Pro Val Phe Ala Asp Val Asp Trp His Lys Ala Leu Asp Trp Leu 325 330 335
Arg Arg Ala Thr Gly Ala Glu Leu Ala Glu Ala Gin Glu Arg Ala Val 340 345 350
Lys Leu Ala Leu Thr Glu Lys Val Ala Val Leu Thr Gly Gly Pro Gly 355 360 365
Cys Gly Lys Ser Phe Thr Val Arg Ser lie lie Ala Leu Ala Gin Ala 370 375 380
Lys Lys Ala Lys Val lie Leu Ala Ala Pro Thr Gly Arg Ala Ala Lys 385 390 395 400
Arg Leu Thr Glu Leu Thr Gly His Asp Ala Ala Thr Val His Arg Leu 405 410 415
Leu Gin Leu Gin Pro Gly Gly Asp Ala Ala Tyr Asp Arg Asp Asn Pro 420 425 430
Leu Asp Ala Asp Leu Val Val Val Asp Glu Ala Ser Met Leu Asp Leu 435 440 445
Leu Leu Ala Asn Lys Leu Ala Lys Ala lie Ala Pro Gly Ala His Leu 450 455 460
Leu Leu Val Gly Asp Val Asp Gin Leu Pro Ser Val Gly Ala Gly Glu 465 470 475 480
Val Leu Arg Asp Leu Leu Ala Pro Gly Thr Pro lie Pro His Val Arg 485 490 495
Leu Asn Glu Val Phe Arg Gin Ala Ala Glu Ser Gly Val Val Thr Asn 500 505 510
Ala His Arg lie Asn Ala Gly Asp Tyr Pro Leu Thr His Gly Leu Thr 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 舞— (請先閱讀背面之注意事項再填寫本頁) ’tr 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 515 520 525
Asp Phe Phe Leu Phe His Val Glu Glu Ser Glu Pro Thr Ala Glu Leu 530 535 540
Thr Val Asp Val Val Ala Arg Arg lie Pro Arg Lys Phe Arg Phe Asn 545 550 555 560
Pro Arg Thr Asp Val Gin Val Leu Ala Pro Met His Arg Gly Pro Ala 565 570 575
Gly Ala Gly Ala Leu Asn Gin Leu Leu Gin Glu Ala lie Thr Pro Ala 580 585 590
Arg Glu Gly Leu Pro Glu Arg Arg Phe Gly Gly Arg lie Phe Arg Val 595 600 605
Gly Asp Lys Val Thr Gin lie Arg Asn Asn Tyr Asp Lys Gly Ala Asn 610 615 620
Gly Val Phe Asn Gly Thr Gin Gly Val Val Ser Ala Leu Asp Asn Glu 625 630 635 640
Ala Gin Thr Met Thr Val Arg Thr Asp Glu Asp Glu Asp lie Asp Tyr 645 650 655
Asp Phe Thr Glu Leu Asp Glu Leu Val His Ala Tyr Ala Val Thr lie 660 665 670
His Arg Ser Gin Gly Ser Glu Tyr Pro Cys Val Val lie Pro Leu Thr 675 680 685
Thr Ser Ala Trp Met Met Leu Gin Arg Asn Leu Leu Tyr Thr Ala Val 690 695 700
Thr Arg Ala Lys Lys Val Val Val Leu Val Gly Ser Lys Lys Ala Leu 705 710 715 720
Gly Gin Ala Val Arg Thr Val Gly Ser Gly Arg Arg His Thr Ala Leu 725 730 735
Asp His Arg Leu Arg Arg Gly Gly Thr Gly Ser Arg Pro Ala Ala 740 745 750 (2)序列辨識號碼:25之資料： 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（） (i) 序列特徵： (A) 長度：2310個氮鹼基對 (B) 型式：核酸 (D)股型：雙股 (D)拓樸學：線形 (ii) 分子形式：DNA(基因組的） (ix)特徵：
(A) 名稱/關鍵：CDS (B) 位置：88..1077 (ix)特徵：
(A) 名稱/關鍵：CDS (B) 位置：1165. .1992 (Xi)序列敘述：序列辨識編號:25 GGATCCTGCT TCGTAGCTCXj GTGTGTCA.TG CCAGACTGCG CACGCGGhCC TGCAGCGGGC 60 CGCGAAATCC 03GCGAGGAA GGGCGCG ATG CX3G ATT CTG GTC ACC GGC GGA 111
Met Arg lie Leu Val Thr Gly Gly 1 5 GCC GGT TTC ATC GGC TCG CAC TAC GTT CGG CAG TTG CTC GGT GGT GCG 159
Ala Gly Phe lie Gly Ser His Tyr Val Arg Gin Leu Leu Gly Gly Ala 10 15 20 TAC CCC GCA TTC GCC GAC GCC GAC GTG GTC GTG CTC GAC AAG CTC ACC 207
Tyr Pro Ala Phe Ala Asp Ala Asp Val Yel ▽丑 1 Iaeu ^sp Lys lieu Thr 25 30 35 40 TAC GCC GGC AAC GAG GCG AAC CTG GCG CCG GTC GCG GAC AAC CCC CGG 255
Tyr Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg 45 50 55 CTG AAG TTC GTC TGC GGC GAC ATC TGC GAC CGC GAA CTG GTT GGC GGC 303
Leu Lys Phe Val Cys Gly Asp lie Cys Asp Arg Glu Leu Val Gly Gly 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） 60 65 70 CTG ATG TCC GGC GTG GAC GTG GTG GTG CAC TTC GCC GCC GAA ACC CAC 351
Leu Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His 75 80 85 GTC GAC CGC TCG ATC ACC GGC TCG GAC GCC TTC GTG ATC ACC AAC GTG 399
Val Asp Arg Ser lie Thr Gly Ser Asp Ala Phe Val lie Thr Asn Val 90 95 100 GTC GGC ACC AAC GTG CTG CTG CAG GCC GCG CTC GAC GCC GAG ATC GGC 447
Val Gly Thr Asn Val Leu Leu Gin Ala Ala Leu Asp Ala Glu lie Gly 105 110 115 120 AAG TTC GTG CAC GTT TCC ACC GAC GAG GTC TAC GGC TCC ATC GAG GAC 495
Lys Phe Val His Val Ser Thr Asp Glu Val Tyr Gly Ser lie Glu Asp 125 130 135 GGC TCG TGG CCC GAA GAC CAC GCG CTG GAG CCG AAT TCC CCG TAC TCG 543
Gly Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser 140 145 150 GCG GCG AAA GCG GGC TCG GAC CTG CTG GCC CGC GCC TAC CAC CGC ACC 591
Ala Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr 155 160 165 CAC GGA CTG CCG GTG TGC ATC ACC CGC TGC TCC AAC AAC TAC GGG CCC 639
His Gly Leu Pro Val Cys lie Thr Arg Cys Ser Asn Asn Tyr Gly Pro 170 175 180 TAC CAG TTC CCX3 GAG AAG GTG CTG CCG CTG TTC ATC ACG AAC CTG ATG 687
Tyr Gin Phe Pro Glu Lys Val Leu Pro Leu Phe lie Thr Asn Leu Met 185 190 195 200 GAC GGC AGC CAG GTG CCG CTC TAC GGC GAC GGG CTC AAC GTG CX3G GAC 735
Asp Gly Ser Gin Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp 205 210 215 TCG CTC CAC GTC AGC GAC CAC TGC CX3G GGC ATC CAG CTG GTG GCC GAC 783
Trp Leu His Val Ser Asp His Cys Arg Gly lie Gin Leu Val Ala Asp 220 225 230 TCC GGG CGC GCG GGC GAG ATC TAC AAC ATC GGC GGC GGC ACC GAG CTG 831
Ser Gly Arg Ala Gly Glu lie Tyr Asn lie Gly Gly Gly Thr Glu Leu 235 240 245 -205 - 本纸張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） (請先聞讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
ACC AAC AAC GAG CTG ACC GAG CX3G CTG CTG GCA GAG CTG GGC CTC GAC Thr Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp 250 255 260 TGG TCG GTG GTG CGG CCG GTC ACC GAC CGC AAG GGC CAC GAC CGC CGC Trp Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg 265 270 275 280 TAC TCX3 GTG GAC CAC AGC AAG ATC GTC GAG GAA CTG GGG TAC GCX3 CCG Tyr Ser Val Asp His Ser Lys lie Val Glu Glu Leu Gly Tyr Ala Pro 285 290 295 CAG GTC GAC TTC GAG ACC GGG CTG CX3C GAG ACA ATC CX3C TGG TAC CAG 879 927 975 1023
Gin Val Asp Phe Glu 300 GAC AAC CGG GAC TGG Asp Asn Arg Asp Trp 315
Gly Leu Arg Glu Thr lie Arg Trp Tyr Gin 305 310 GAG CCG CTG AAG GCC CGh TCX5 GCG GTG GCT Glu Pro Leu Lys Ala Arg Ser Ala Val Ala 320 325
CGA TGA. GTCX3CCTCX3C CGTGCTGG1T GCCCX3GCGGC Arg * 329 GCTGGCCCGG ATCCTCGCCG CGCGGACGGG
GA.C GTC ACC GAC GCC
GTG CAC CX3G CCG GGT TCC Val His Arg Pro Gly Ser 1 5 JTC GCC GAC GCG TTG GGT
Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala Asp Ala Leu Gly 20 10 15 TCC TTC GCG GAG ACG GCG AAG GAC GCG GAG CTG Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu Leu 25 30 AAC GCC GCG GCG TAC ACG GCG GTG GAC GCG GCC Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu Ser Asp Pro Asp 40 45 50 CGC GCG GCC CCG ATC AAC GCC GAA GGC GCG GCC TCG CTG GCG AAA GCX3 Arg Ala Ala Arg lie Asn Ala Glu Gly Ala Ala Ser Leu Ala Lys Ala
CCG GTG GTG ATC Pro Val Val lie 35 TCC GAC CCG GAC (請先閲讀背面之注意事項再填寫本頁) 1071 1127 1182 1230 1278 1326 1374 訂 55
60 65 ΠΌ CCC CTG GTG CAC GTG
ACG GAT TAC 70 1422 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 1237058 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（
Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser Thr Asp Tyr Val 75 80 85 TTC CCC CGT GAT GGG GCC CX3G CCG TAC GAG CCX3 ACG GAC CCG ACC GGG Phe Pro Arg Asp Gly Ala Arg Pro Tyx Glu Pro Thr Asp Pro Thr Gly 90 95 loo CCG CGA TCG GTC TAC GGG CGC ACC AA.G CTC GAA GGC GAA COG GCC GTC Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly Glu Arg Ala Val 105 110 115 CTG GAG TCC GGC GCG CX3G GCC TGG GTG GTG CGC ACG GCA TCG GTC TAC Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr Ala Trp Val Tyr 120 125 130 GGC GCG AGC GGC AA.G AAC TTC CTG AAA ACG ATG ATC CX3C CTC TCG GGG Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met lie Arg Leu Ser Gly 135 140 145 150 GAG CX3C GAC ACG CTG TCC GTT GTG GAC AAT CAG ATC GGC TCX3 CCX3 ACT Glu Arg Asp Thr Leu Ser Val Val Asp Asn Gin lie Gly Ser Pro Thr 155 160 165 TGG GCG GCG GAC CTG GCG AGC GGC CTG CTG GAG CTG GCC GAA CGG GTC Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu Ala Glu Arg Val 170 175 180 GCC GAA CX3C CX3T GGA CCG GAG CAG AAG GTG CTG CAC TGC ACC AAT TCC Ala Glu Arg Arg Gly Pro Glu Gin Lys Val Leu His Cys Thr Asn Ser 185 190 GGC CAG GTG ACC TGG TAC GAG TTC GCG CX3G Gly Gin Val Thr Trp Tyr Glu Phe Ala Arg 200 205 GGC CTG GAC GAG AAC CGC GTC CAC CCG TGC Gly Leu Asp Glu Asn Arg Val His Pro Cys 195 GCG ATC TTC GCG GAA TTC Ala lie Phe Ala Glu Phe 210 ACG ACG GCG GAC TTC CCC Thr Thr Ala Asp Phe Pro 215 220 CTC CCG GCG CAC CGC CCG GCC TAC TCG GTC CTG TCC GAC GTG GCG TGG Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser Asp Val Ala Trp 235 CGA. GAG GCG GGC CTG ACC CCG ATG Arg Glu Ala Gly Leu Thr Pro Met 1470 1518 1566 1614 1662 1710 1758 1806 1854 舞—(請先閲讀背面之注意事項再填寫本頁) 225 230 1902 240 ACC TGG Thr Trp •207 - 245 GAA GCC CTG GCG Glu Ala Leu Ala 1950 本紙張尺度適用中國國家標準（CNS ) Α4規格（210X297公釐） 1237058 at B7 五、發明説明（） 250 255 260 GCG GCC TTC GAG AAA GAC GGC GAA ACC CTC CX3A. ACC CX3C TGA 1992
Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr Arg * 265 270 275 CCAGTCACCC GGA.GGGCX3CG AGTAGCCCCX3 GCAGGGCCGT TTCX3ACGCGA TATCX3GCTGG 2052 CX3CX3GTGCGC ACAATGGGTG TCX3CCX3GGGC GAGGAAGGAA GGCCAGGTGC CCCX3GGGGCA. 2112 TGACTGGGAG CCTGGCCTGA TGCCTGTCCG GGGCGTTCAG CCTGCGGCGA GGCGGTATGC 2172 GTTCAGGGTT GCTTCGGCGC AGGTTCX3CCA GGTGAAGGCT TTAGCTTGGG CAOSGCCCTT 2232 TTCCX3CGTCT GGGGGACTGG TCAGGGCTTG GTGCAGGGCT TCGTTGZ^GGG CCX5TCX3GGTC 2292 GCCGTGGGGG AAGCGGAT 2310 (2)序列辨識號碼:26之資料： (i) 序列特徵： (A) 長度：329個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:26
Met Arg lie Leu Val Thr Gly Gly Ala Gly Phe lie Gly Ser His Tyr 15 10 15
Val Arg Gin Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 20 25 30
Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 35 40 45
Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp lie 50 55 60
Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 65 70 75 80
Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser lie Thr Gly Ser 85 90 95
Asp Ala Phe Val lie Thr Asn Val Val Gly Thr Asn Val Leu Leu Gin 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（ 100 105 110
Ala Ala Leu Asp Ala Glu He Gly Lys Phe Val His Val Ser Thr Asp 115 120 125
Glu Val Tyr Gly Ser lie Glu Asp Gly Ser Trp Pro Glu Asp His Ala 130 135 140
Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 145 150 155 160
Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys lie Thr 165 170 175
Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gin Phe Pro Glu Lys Val Leu 180 185 190
Pro Leu Phe lie Thr Asn Leu Met Asp Gly Ser Gin Val Pro Leu Tyr 195 200 205
Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 210 215 220
Arg Gly lie Gin Leu Val Ala Asp Ser Gly Arg Ala Gly Glu lie Tyr 225 230 235 240
Asn lie Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 245 250 255
Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 260 265 270
Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys lie 280 285 .Ala Pro Gin Val Asp Phe Glu Thr Gly Leu 295 300
Arg Glu Thr lie Arg Trp Tyr Gin Asp Asn Arg Asp Trp Trp Glu Pro 305 310 315 320
Leu Lys Ala Arg Ser Ala Val Ala Arg 325 (2)序列辨識號碼:27資料： 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 舞丨 (請先閲讀背面之注意事項再填寫本頁) 訂 275 Val Glu Glu Leu Gly 290 經濟部智慧財產局員工消費合作社印製 1237058 A7 B7 五、發明説明（) (0序列特徵： (請先聞讀背面之注意事項再填寫本頁) (A) 長度：275個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii)分子形式：蛋白質 (xi)序列敘述：序列辨識編號:27
Val His Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu 1 5 10 15
Val Ala Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu 20 25 30
Leu Arg Pro Val Val lie Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala 35 40 45
Ala Glu Ser Asp Pro Asp Arg Ala Ala Arg lie Asn Ala Glu Gly Ala 50 55 60
Ala Ser Leu Ala Lys Ala Cys Arg Ser Ser Gly Ijeu Pro Leu Val His 65 70 75 80
Val Ser Thr Asp Tyr Val Phe Pro Arg Asp Gly Ala Arg Pro Tyr Glu 85 90 95
Pro Thr Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu 100 105 110 經濟部智慧財產局員工消費合作社印製
Glu Gly Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val 115 120 125
Arg Thr Ala T:cp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr 130 135 140
Met lie Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asn 145 150 155 160
Gin lie Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu 165 170 175
Glu Leu Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gin Lys Val 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 1237058 at B7 五、發明説明（） 180 185 190
Leu His Cys Thr Asn Ser Gly Gin Val Thr Trp Tyr Glu Phe Ala Arg 195 200 205
Ala He Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys 210 215 220
Thr Thr Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val 225 230 235 240
Leu Ser Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr 245 250 255
Trp Arg Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu 260 265 270
Arg Thr Arg 275 (2)序列辨識號碼:28之資料： (i) 序列特徵： (A) 長度：1272個氮鹼基對 (B) 型式：核酸 (D)股型：雙股 (D)拓樸學：線形 (ii) 分子形式：DNA (基因組的） (ix)特徵：
(A) 名稱/關鍵：CDS (B) 位置：334..1119 (xi)序列敘述：序列辨識編號:28 AA.GGCCACCG GCAAGGTCGT GCAGGGCATC TCX3CAGGACG TO30GAAGAA GATCTCCAAG 60 AAGA.TCCGCX3 ACGAGGGCCC GAAGGGCXSTT CAGGCCCAGA TCCAGGGCGA GCAGCTGCGG 120 GTCTCCGGCA AGAAGAAGGA (^CCTGCAG GCCX3TGATCC AGTTGCTGAA GTCGAGCGAC 180 TTCGACGTCG CGCTCCAGTT CGAGAATTTC CGGTAATCCA CCGCTGGAGG TATCCGGGTG 240 本紙張尺度適用中國國家標準（CNS ) Α4規格（21〇χ297公釐） #1 (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） AAGGGGATCG TGCTGGCGGG TGGCAACX3GG ACC03GCTGC ATCCX3CTGA.C GCAGGCCXjTC 300 TCCAAACAGC TACTTCCX3GT GTACGACAAG CCG ATG ATC TAC TAC CCG CTG TCX5 354
Met lie Tyr Tyr Pro Leu Ser 1 5 GTG CTG ATG CTG GCC GGC ATC CGG GAC GTG CTG CTG ATC TCG ACC CCX3 402
Val Leu Met Leu Ala Gly lie Arg Asp Val Leu Leu lie Ser Thr Pro 10 15 20 GCC GAC ATG CCX3 TTG TTC CAG CX3G CTG CTC GGG AAC GGG TCG CAG TTC 450
Ala Asp Met Pro Leu Phe Gin Arg Leu Leu Gly Asn Gly Ser Gin Phe 25 30 35 GGC ATT CGG ATC GAG TAC GCC GAG CAG TCC CAG CCC AAC GGG CTA GCC 498
Gly lie Arg lie Glu Tyr Ala Glu Gin Ser Gin Pro Asn Gly Leu Ala 40 45 50 55 GAG GCG TTC GTG ATC GGT GCC GAC TTC GTC GGC GAC GAC TCG GTG GCG 546
Glu Ala Phe Val lie Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala 60 65 70 TTG GTG CTC GGC GAC AAC ATC TTT TAC GGG CAG GGC ΤΓΤ TCC GGG ATC 594
Leu Val Leu Gly Asp Asn lie Phe Tyr Gly Gin Gly Phe Ser Gly lie 75 80 85 CTC CAG CAG TGC GTC CGG GAG CTC GAC GGC TGC ACG CTG TTC GGC TAC 642
Leu Gin Gin Cys Val Arg Glu Leu Asp Gly Cys ΊΊιτ Leu Phe Gly Tyr 90 95 100 CCG GTC CGC GAC CCG CAG CGC TAC GGC GTC GGT GAG GTG GAC GAC GAC 690
Pro Val Arg Asp Pro Gin Arg Tyr Gly Val Gly Glu Val Asp Asp Asp 105 110 115 GGT CGG CTG ΊΊΌ TCC ATC GTG GAG AAG CCG GAG CGG CCG AAG TCC AAC 738
Gly Arg Leu Leu Ser lie Val Glu Lys Pro Glu Arg Pro Lys Ser Asn 120 125 130 135 ATG GCC ATC ACC GGC CTG TAC TTC TAC GAC AAC GAC GTG GTG CGC ATC 786
Met Ala lie Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg lie 140 145 150 GCC AAG GGG CTC ACG CCG TCG GCC CGC GGC GAG CTG GAG ATC ACC GAC 834
Ala Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu lie Thr Asp 155 160 165 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） (請先閱讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（ GTC AAC CTG GCC TAC CTG CAG GAG GGC CGG GCG CAC CTG ACC AAG CTC Val Asn Leu Ala Tyr Leu Gin Glu Gly Arg Ala His Leu Thr Lys Leu 170 175 180 GGC CX3C GGG TTC GCC TGG CTG GAC ACC GGG ACC CAC GAC TCG CTA GTC Gly Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val 185 190 195 GAG GCC TCG CAG TTC GTG CAG GTG CTG GAG CAC CGG CAG GGC GTG CGG Glu Ala Ser Gin Phe Val Gin Val Leu Glu His 200 205 210 ATC GCC TGC CTG GAG GAG ATC NCC CTG CGC ATG 工le Ala Cys Leu Glu Glu lie ??? Leu Arg Met Gly Tyr lie Ser Ala 220 225 230 GAC GAC TGT TTC GCG CTG GGC GTG AAG CTG GCC AAG TCG GGC TAC AGC Asp Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Ser 235 240 245 GAG TAC GTC ATG GAC GTC GCC CX3C AAC TCC GGC GCG CGG GGC TGA Glu Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly 250 255 260 CCCGAGCTCG TCCGATTTCC ATTGAAATCX3 CX3GACCGTCX? GCX5TGTCGTA GTCCX3GTGCG CCX3ATATTCC GGGCX3GCGTC ACCAGGCCGG GGGTAG1TGG TGGCCGGCCA TGCCCTCCAG GCGGCGAAAT GCGGTCGGCC ATCGGCGGGT TGC (2)序列辨識號碼:29資料： (i) 序列特徵： (A) 長度：261個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (ix)特徵： (A) 名稱/關鍵：不確定 (B) 位置：223 -213 - 本紙張又度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） 882 930 978
Gin Gly Val Arg 215 TAC ATC TCG GCC 1026 1074 1119 1179 1239 1272 ----------(請先閲讀背面之注意事項再填寫本頁)
、1T 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） (xi)序列敘述：序列辨識編號:29
Met lie Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly lie Arg Asp 15 10 15
Val Leu Leu lie Ser Thr Pro Ala Asp Met Pro Leu Phe Gin Arg Leu 20 25 30
Leu Gly Asn Gly Ser Gin Phe Gly lie Arg lie Glu Tyr Ala Glu Gin 35 40 45
Ser Gin Pro Asn Gly Leu Ala Glu Ala Phe Val lie Gly Ala Asp Phe 50 55 60
Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn lie Phe Tyr 65 70 75 80
Gly Gin Gly Phe Ser Gly lie Leu Gin Gin Cys Val Arg Glu Leu Asp 85 90 95
Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gin Arg Tyr Gly 100 105 110
Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser lie Val Glu Lys 115 120 125
Pro Glu Arg Pro Lys Ser Asn Met Ala lie Thr Gly Leu Tyr Phe Tyr 130 135 140
Asp Asn Asp Val Val Arg lie Ala Lys Gly Leu Thr Pro Ser Ala Arg 145 150 155 160
Gly Glu Leu Glu lie Thr Asp Val Asn Leu Ala Tyr Leu Gin Glu Gly 165 170 175
Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 180 185 190
Gly Thr His Asp Ser Leu Val Glu Ala Ser Gin Phe Val Gin Val Leu 195 200 205
Glu His Arg Gin Gly Val Arg lie Ala Cys Leu Glu Glu lie Xaa Leu 210 215 220 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 訂 線 (請先閲讀背面之注意事項再填寫本頁) 1237058 at B7 五、發明説明（）
Arg Met Gly Tyr lie Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 225 230 235 240 (請先閲讀背面之注意事項再填寫本頁)
Leu Ala Lys Ser Gly Tyr Ser Glu Tyr Val Met Asp Val Ala Arg Asn 245 250 255
Ser Gly Ala Arg Gly 260 (2)序列辨識號碼:30之資料： (i) 序列特徵： (A) 長度：23個氮鹼基對 (B) 型式：核酸 (D)股型：單股 (D)拓樸學：線形 (ii) 分子形式：DNA (ix)特徵： (A) 名稱/關鍵：經修飾的氮鹼基 (B) 位置：1 (D)其他資料：/經修飾的氮鹼基=i (ix)特徵： (A) 名稱/關鍵：經修飾的氮鹼基 經濟部智慧財產局員工消費合作社印製 (B) 位置：10 (D)其他資料：/經修飾的氮鹼基=i (xi)序列敘述：序列辨識編號:30 NGSGTSGGSN SSCCACCTTC CGG 23 (2)序列辨識號碼:31之資料： (i)序列特徵： 本紙張尺度適用中國國家標準（CNS ) A4規格（210X 297公釐） 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） (A) 長度：33個氮鹼基對 (B) 型式：核酸 (D)股型：單股 (D)拓樸學：線形 (ii)分子形式：DNA (ix)特徵： (A) 名稱/關鍵：經修飾的氮鹼基 (B) 位置：6 (D)其他資料：/經修飾的氮鹼基=i (ix)特徵： (A) 名稱/關鍵：經修飾的氮鹼基 (B) 位置：18 (D)其他資料：/經修飾的氣驗基=i (xi)序列敘述：序列辨識編號:31 CATSANGTCG TCYTCSANSG CSACGAACGC GTG 33 (2)序列辨識號碼:32之資料： (i) 序列特徵： (A) 長度：1165個氮鹼基對 (B) 型式：核酸 (D)股型：單股 〇0)拓樸學：線形 (ii) 分子形式：DNA (ix)特徵：
(A)名稱/關鍵：CDS 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） 訂 線 (請先閱讀背面之注意事項再填寫本頁) 1237058 at B7 經濟部智慧財產局員工消費合作社印製 五、發明説明（） (B)位置：226· .834 (xi)序列敘述：序列辨識編號:32 GGGATCAACA ACAACTTCAC CAGCAGGTTC AAC^TTTGT OVATCCCACT TGGCA.GTACG CGCGTCCTTT TTGGATCGGG ATTGCGGCAG TACGTGCACC CGGTTTCAGT GCCCCATTTC GCAGTACX3TA CGTCCGITIT GAATATGGCG ATCAATGGCT CGCA.TGA.CCC ATATCAACTC CGCCCCACCX3 AACCX3CATTC CAACCAACGT CATAGGCTTT CGGCC GTG CAG GTA Val Gin Val 1 CGT CX3A CTT GAC ATC ACX3 GGT GCA TAC GAG TTC ACC CCG AAG GCC TTC Arg Arg Leu Asp lie Thr Gly Ala Tyr Glu Phe Thr Pro Lys Ala Phe 5 10 15 CCC GA.C CAC CX3G GGC CTG TTC GTG GCC CCG TTC CAG GAG GCG GCG TTC Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gin Glu Ala Ala Phe 20 25 30 35 ATC GAC GCC ACG GGG CAC CCG CTG CGA GTC GCG CAG ACC AAC CAC AGC 工le Asp Ala Thr Gly His Pro Leu Arg Val Ala Gin ΊΤιτ Asn His Ser 60 120 180 234 282 330 378
GTC
40 AAC GTC ATC
45 50 GTG CAC TTC TCG GAC GTG CCG 426
Val Ser Ala Arg Asn Val lie Arg Gly Val His Phe Ser Asp Val Pro 55 60 65 CCG GGC CAA GCG AAG TAC GTG TAC TGC CCG CAG GGC GCG CTG CTC GAC Pro Gly Gin Ala Lys Tyr Val Tyr Cys Pro Gin Gly Ala Leu Leu Asp 70 75 80 GTG GTC ATC GAC ATC CGG GTC GGT TCC CCX3 ACC TTC GGC CGC TGG GAG Val Val lie Asp lie Arg Val Gly Ser Pro Thr Phe Gly Arg Trp Glu
85 90 GCG GTC CGG CTC GAC GAC ACC GAG TAC Ala Val Arg Leu Asp Asp Thr Glu Tyr 100 105 GGA CTC GC3G CAC GCG TTC GCC GCG CTG
95 CGG GCC GTC TAC CTA GCC GAA Arg Ala Val Tyr Leu Ala Glu 110 115 ACC GAC GAC ACC GTG ATG ACC
Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr Val Met
TAC
120 125 130 ACG CCC TAC ACC CCG GGC GCC GAG CAC GGC ATC GAC 本紙張尺度適用中國國家標準（CNS ) A4規格（210 X 297公釐） 474 522 570 618 666 I I I I I I II 訂— — —— I 線 (請先閱讀背面之注意事項再填寫本頁) 1237058 A7 B7 五、發明説明（ 經濟部智慧財產局員工消費合作社印製 :Pro Gly Ala Glu His Gly lie Asp 140 145 J CCG TGG TCC GAC CTC GAC GGT GAA Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu Asp Gly Glu 150 155 160 CCG GTC CTG TCC GAA AAG GAC CGG ACC GCC CCX3 AGC CTC GCG GAA GCC Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu Ala Glu Ala 165 170 175 GCC GAC AAC GGC CTG CTT CCG GAC TAC GAA ACA TGC CTC GCC CAC TAC Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu Ala His Tyr 180 185 190 195 GAA GGC CTG CGC AGC CCC GGC TGA ACX3GTCA.CCG CAAGCGGCCC GGCTTCX3GCC Glu Gly Leu Arg Ser Pro Gly * 200 AGAGGCGCCA CCGGATAATG CCX3AGCACCT CGGCCGGGCC GAGCTCCCGC GA.GTCCX3TCG AGCCX3AAGTT GTTGTCX3CCC TCGACGTACC AGCCATCX3CC CTCGCGGCGC AGCGCX3CGCT TCACCGACAA CTGCCCCGGG CGCTGGGCCC AACGCACCAG CACGACGTTT CCCCGGCCGG GCGGAACCCC GAAGCCGCAG CAGCACCACT TCX3CGATCCC GCAGGGTGGG AACCATAAAC GGCCCGCGCA CCACCAACCG CCGCCAGGGC CAGCGCCCGA GGGMTTCAC ATCCACCTCC A (2)序列辨識號碼:33資料： (i) 序列特徵： (A) 長度：202個胺基酸 (B) 型式：胺基酸 (D)拓樸學：線形 (ii) 分子形式：蛋白質 (xi)序列敘述：序列辨識編號:33 Val Gin Val Arg Arg Leu Asp lie r
Tyr Leu Cys Ser Thr Pro Tyr 135 CCG TTC GAC CC!G GAA CTC GCG 714 762 810 864 924 984 1044 1104 1164 1165
Gly Ala Tyr Glu Phe Thr Pro 10 15
Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gin Glu -218 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） I----------M0 — (請先閲讀背面之注意事項再填寫本頁) 訂 -線； 經濟部智慧財產局員工消費合作社印製 1237058 五、發明説明（） 20 25 30
Ala Ala Phe lie Asp Ala Thr Gly His Pro Leu Arg Val Ala Gin Thr 35 40 45
Asn His Ser Val Ser Ala Arg Asn Val lie Arg Gly Val His Phe Ser 50 55 60
Asp Val Pro Pro Gly Gin Ala Lys Tyr Val Tyr Cys Pro Gin Gly Ala 65 70 75 80
Leu Leu Asp Val Val lie Asp lie Arg Val Gly Ser Pro Thr Phe Gly 85 90 95
Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 100 105 110
Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 115 120 125
Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 130 135 140
Gly lie Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 145 150 155 160
Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 165 170 175
Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 180 185 190
Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 195 200 (2)序列辨識號碼:34之資料： (i)序列特徵： (A) 長度：28個氮鹼基對 (B) 型式：核酸 (D)股型：單股 (D)拓樸學：線形 -219 - 本紙張尺度適用中國國家標準（CNS )八4規格（21〇χ297公董） ----------—-----訂------線 (請先閲讀背面之注意事項再填寫本頁) 1237058 at B7 五、發明説明（）
(ii)分子形式：DNA (xi)序列敘述：序列辨識編號:34 CCCGAATTCG AGCTGCTGTC AATCAACT 28 (2)序列辨識號碼:35之資料： (i) 序列特徵： (A) 長度：29個氮鹼基對 (B) 型式：核酸 (D)股型：單股 (D)拓樸學：線形
(ii) 分子形式：DNA (xi)序列敘述：序列辨識編號:35 GGGAAGCTTG TTGACCGTGG CGGTTTCCT 29 (2)序列辨識號碼:36之資料： (i) 序列特徵： (A) 長度：42個氮鹼基對 (B) 型式：核酸 (D)股型：單股 (D)拓樸學：線形
(ii) 分子形式：DNA (xi)序列敘述：序列辨識編號:36 CTGGTTCATT CGGCCGCCTC ACCGGTGGGG ATGGCCGCGA TC 42 (2)序列辨識號碼:37之資料： (i)序列特徵： (A)長度：42個氮鹼基對 本紙張尺度適用中國國家標準（CNS ) Α4規格（210Χ297公釐） I--------- (請先聞讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製 1237058 at B7 五、發明説明（） (B)型式：核酸 (D)股型：單股 (D)拓樸學：線形 (ii)分子形式：DNA (xi)序列敘述：序列辨識編號:37 GATCGCGGCC ATCCCCACCG GTGAGGCGGC CGAATGAACC AG 42 (2)序列辨識號碼:38之資料： (i) 序列特徵： (A) 長度：20個氮鹼基對 (B) 型式：核酸 (D)股型：單股 (D)拓樸學：線形
(ii) 分子形式：DNA (xi)序列敘述：序列辨識編號:38 GCTGCTCGAA ATCGCACGTC 20 (2)序列辨識號碼:39之資料： ①序列特徵： (A) 長度：19個氮鹼基對 (B) 型式：核酸 (D)股型：單股 (D)拓樸學：線形
(ii)分子形式：DNA (xi)序列敘述：序列辨識編號:39 GCATCGCTGG GCAGTGAGG 19 -221 - 本紙張尺度適用中國國家標準（CNS ) A4規格（210X297公釐） I---------^0 — (請先閲讀背面之注意事項再填寫本頁) 訂 經濟部智慧財產局員工消費合作社印製

Claims (1)

1237058 W日修正， 補无六、申請專利範圍 第088 103537號專利再審查案申請專利範圍修正本 94年5月 1. 一種分離的DNA分子，其由一個編碼史賓諾辛生物合成 酵素的DNA序列所組成，其中該酵素係為一値擇自於下 面所示的序歹)J辨識編號：2-5、7-24、26、27、29、33 之組群中的胺基酸序列所定義： 序列辨識編號:2 Met Ser Glu Ala Gly Asn Leu lie Ala Val lie Gly Leu Ser Cys Arg 1 5 10 15 Leu Pro Gin Ala Pro Asp Pro Ala Ser Phe Trp Arg Leu Leu Arg Thr 20 25 30 Gly Thr Asp Ala lie Thr Thr Val Pro Glu Gly Arg Trp Gly Asp Pro 35 40 45 Leu Pro Gly Arg Asp Ala Pro Lys Gly Pro Glu Trp Gly Gly Phe Leu 50 55 60 Ala Asp Val Asp Cys Phe Asp Pro Glu Phe Phe Gly lie Ser Pro Arg 65 70 75 80 Glu Ala Ala Thr Val Asp Pro Gin Gin Arg Leu Ala Leu Glu Leu Ala 85 90 95 Trp Glu Ala Leu Glu Asp Ala Gly lie Pro Ala Gly Glu Leu Arg Gly 100 105 110 Thr Ala Ala Gly Val Phe Met Gly Ala lie Ser Asp Asp Tyr Ala Ala 115 120 125 Leu Leu Arg Glu Ser Pro Pro Glu Val Ala Ala Gin Tyr Arg Leu Thr 130 135 140 Gly Thr His Arg Ser Leu lie Ala Asn Arg Val Ser Tyr Val Leu Gly 145 150 155 160 Leu Arg Gly Pro Ser Leu Thr Val Asp Ser Gly Gin Ser Ser Ser Leu 165 170 175 Val Gly Val His Leu Ala Ser Glu Ser Leu Arg Arg Gly Glu Cys Thr 180 185 190 lie Ala Leu Ala Gly Gly Val Asn Leu Asn Leu Ala Ala Glu Ser Asn 195 200 205 Ser Ala Leu Met Asp Phe Gly Ala Leu Ser Pro Asp Gly Arg Cys Phe 210 215 220 Thr Phe Asp Val Arg Ala Asn Gly Tyr Val Arg Gly Glu Gly Gly Gly
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1237058 六 、申請專利範圍 225 230 235 240 Leu Val Val Leu Lys Lys Ala Asp Gin Ala His Ala Asp Gly Asp Arg 245 250 255 lie Tyr Cys Leu lie Arg Gly Ser Ala Val Asn Asn Asp Gly Gly Gly 260 265 270 Ala Gly Leu Thr Val Pro Ala Ala Asp Ala Gin Ala Glu Leu Leu Arg 2 75 280 285 Gin Ala Tyr Arg Asn Ala Gly Val Asp Pro Ala Ala Val Gin Tyr Val 290 295 300 Glu Leu His Gly Ser Ala Thr Arg Val Gly Asp Pro Val Glu Ala Ala 305 310 315 320 Ala Leu Gly Ala Val Leu Gly Ala Ala Arg Arg Pro Gly Asp Glu Leu 325 330 335 Arg Val Gly Ser Ala Lys Thr Asn Val Gly His Leu Glu Ala Ala Ala 340 345 350 Gly Val Thr Gly Leu Leu Lys Thr Ala Leu Ser lie Trp His Arg Glu 355 360 365 Leu Pro Pro Ser Leu His Phe Thr Ala Pro Asn Pro Glu lie Pro Leu 370 375 380 Asp Glu Leu Asn Leu Arg Val Gin Arg Asp Leu Arg Pro Trp Pro Glu 385 390 395 400 Ser Glu Gly Pro Leu Leu Ala Gly Val Ser Ala Phe Gly Met Gly Gly 405 410 415 Thr Asn Cys His Leu Val Leu Ser Gly Thr Ser Arg Val Glu Arg Arg 420 425 430 Arg Ser Gly Pro Ala Glu Ala Thr Met Pro Trp Val Leu Ser Ala Arg 435 440 445 Thr Pro Val Ala Leu Arg Ala Gin Ala Ala Arg Leu His Thr His Leu 450 455 460 Asn Thr Ala Gly Gin Ser Pro Leu Asp Val Ala Tyr Ser Leu Ala Thr 465 470 4 75 480 Thr Arg Ser Ala Leu Pro His Arg Ala Ala Leu Val Ala Asp Asp Glu 485 490 495 Pro Lys Leu Leu Ala Gly Leu Lys Ala Leu Ala Asp Gly Asp Asp Ala 500 505 510 Pro Thr Leu Cys His Gly Ala Thr Ser Gly Glu Arg Ala Ala Val Phe 515 520 525 Val Phe Pro Gly Gin Gly Ser Gin Trp lie Gly Met Gly Arg Gin Leu 530 535 540 Leu Glu Thr Ser Glu Val Phe Ala Ala Ser Met Ser Asp Cys Ala Asp
2 1237058 六 、申請專利範圍 545 550 555 560 Ala Leu Ala Pro His Leu Asp Trp Ser Leu Leu Asp Val Leu Arg Asn 565 570 575 Ala Ala Gly Ala Ala His Leu Asp His Asp Asp Val Val Gin Pro Ala 580 585 590 Leu Phe Ala lie Met Val Ser Leu Ala Glu Leu Trp Arg Ser Trp Gly 595 600 605 Val Arg Pro Val Ala Val Val Gly His Ser Gin Gly Glu lie Ala Ala 610 615 620 Ala Cys Val Ala Gly Ala Leu Ser Val Arg Asp Ala Ala Arg Val Val 625 630 635 640 Ala Val Arg Ser Arg Leu Leu Thr Ala Leu Ala Gly Ser Gly Ala Met 645 650 655 Ala Ser Leu Gin His Pro Ala Glu Glu Val Arg Gin lie Leu Leu Pro 660 665 670 Trp Arg Asp Arg He Gly Val Ala Gly Val Asn Gly Pro Ser Ser Thr 675 680 685 Leu Val Ser Gly Asp Arg Glu Ala Met Ala Glu Leu Leu Ala Glu Cys 690 695 700 Ala Asp Arg Glu Leu Arg Met Arg Arg lie Pro Val Glu Tyr Ala Ser 705 710 715 720 His Ser Pro His lie Glu Val Val Arg Asp Glu Leu Leu Gly Leu Leu 725 730 735 Ala Pro Val Glu Pro Arg Thr Gly Ser lie Pro lie Tyr Ser Thr Thr 740 745 750 Thr Gly Asp Leu Leu Asp Arg Pro Met Asp Ala Asp Tyr Trp Tyr Arg 755 760 765 Asn Leu Arg Gin Pro Val Leu Phe Glu Ala Ala Val Glu Ala Leu Leu 7 70 775 780 Lys Arg Gly Tyr Asp Ala Phe lie Glu lie Ser Pro His Pro Val Leu 7 85 790 7 95 800 Thr Ala Asn lie Gin Glu Thr Ala Val Arg Ala Gly Arg Glu Val Val 805 810 815 Ala Leu Gly Thr Leu Arg Arg Gly Glu Gly Gly Met Arg Gin Ala Leu 820 825 830 Thr Ser Leu Ala Arg Ala His Val His Gly Val Ala Ala Asp Trp His 835 840 845 Ala Val Phe Ala Gly Thr Gly Ala Gin Arg Val Asp Leu Pro Thr Tyr 850 855 860 Ala Phe Gin Arg Gin Arg Tyr Trp Leu Asp Ala Lys Leu Pro Asp Val
3 1237058 / \ 、申請專利範圍 865 870 875 880 Ala Met Pro Glu Ser Asp Val Ser Thr Ala Leu Arg Glu Lys Leu Arg 885 890 895 Ser Ser Pro Arg Ala Asp Val Asp Ser Thr Thr Leu Thr Met lie Arg 900 905 910 Ala Gin Ala Ala Val Val Leu Gly His Ser Asp Pro Lys Glu Val Asp 915 920 925 Pro Asp Arg Thr Phe Lys Asp Leu Gly Phe Asp Ser Ser Met Val Val 930 935 940 Glu Leu Cys Asp Arg Leu Asn Ala Ala Thr Gly Leu Arg Leu Ala Pro 945 950 955 960 Ser Val Val Phe Asp Cys Pro Thr Pro Asp Lys Leu Ala Arg Gin Val 965 970 975 Arg Thr Leu Leu Leu Gly Glu Pro Ala Pro Met Thr Ser His Arg Pro 980 985 990 Asp Ser Asp Ala Asp Glu Pro lie Ala Val lie Gly Met Gly Cys Arg 995 1000 1005 Phe Pro Gly Gly Val Ser Ser Pro Glu Glu Leu Trp Gin Leu Val Ala 1010 1015 1020 Ala Gly Arg Asp Val Val Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp 1025 1030 1035 1040 Leu Glu Arg Ala Gly Thr Ser His Val Arg Ala Gly Gly Phe Leu His 1045 1050 1055 Gly Ala Pro Asp Phe Asp Pro Gly Phe Phe Arg lie Ser Pro Arg Glu 1060 1065 1070 Ala Leu Ala Met Asp Pro Gin Gin Arg Leu Leu Leu Glu lie Ala Trp 1075 1080 1085 Glu Ala Val Glu Arg Gly Gly lie Asn Pro Gin His Leu His Gly Ser 1090 1095 1100 Gin Thr Gly Val Phe Val Gly Ala Thr Ser Leu Asp Tyr Gly Pro Arg 1105 1110 1115 1120 Leu His Glu Ala Ser Glu Glu Ala Ala Gly Tyr Val Leu Thr Gly Ser 1125 1130 1135 Thr Thr Ser Val Ala Ser Gly Arg Val Ala Tyr Ser Phe Gly Phe Glu 1140 1145 1150 Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 1155 1160 1165 Leu His Leu Ala Cys Gin Ser Leu Arg Ser Gly Glu Cys Asp Leu Ala 1170 117 5 1180 Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Gly Met Phe Val Glu
4 1237058 六 、申請專利範圍 1185 1190 1195 1200 Phe Ser Arg Gin Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe 1205 1210 1215 Ala Glu Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly Leu Val 1220 1225 1230 Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Glu Val Leu 1235 1240 1245 Ala Val Val Arg Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn Gly 1250 1255 1260 Leu Thr Ala Pro Asn Gly Ser Ser Gin Gin Arg Val lie Ala Gin Ala 1265 1270 1275 1280 Leu Ala Ser Ala Gly Leu Ser Val Ser Asp Val Asp Ala Val Glu Ala 1285 1290 1295 His Gly Thr Gly Thr Arg Leu Gly Asp Pro lie Glu Ala Gin Ala Leu 1300 1305 1310 lie Ala Thr Tyr Gly Gin Gly Arg Leu Pro Glu Arg Pro Leu Trp Leu 1315 1320 1325 Gly Ser Met Lys Ser Asn lie Gly His Ala Gin Ala Ala Ala Gly lie 1330 1335 1340 Ala Gly Val Met Lys Met Val Met Ala Met Arg His Gly Gin Leu Pro 1345 1350 1355 1360 Arg Thr Leu His Val Asp Glu Pro Thr Ser Gly Val Asp Trp Ser Ala 1365 13 7 0 1375 Gly Thr Val Gin Leu Leu Thr Glu Asn Thr Pro Trp Pro Gly Ser Gly 1380 1385 1390 Arg Val Arg Arg Val Gly Val Ser Ser Phe Gly lie Ser Gly Thr Asn 1395 1400 1405 Ala His Val lie Leu Glu Gin Pro Pro Gly Val Pro Ser Gin Ser Ala 1410 1415 1420 Gly Pro Gly Ser Gly Ser Val Val Asp Val Pro Val Val Pro Trp Met 1425 1430 1435 1440 Val Ser Gly Lys Thr Pro Glu Ala Leu Ser Ala Gin Ala Thr Ala Leu 1445 1450 1455 Met Thr Tyr Leu Asp Glu Arg Pro Asp Val Ser Ser Leu Asp Val Gly 1460 1465 1470 Tyr Ser Leu Ala Leu Thr Arg Ser Ala Leu Asp Glu Arg Ala Val Val 1475 1480 1485 Leu Gly Ser Asp Arg Glu Thr Leu Leu Cys Gly Val Lys Ala Leu Ser 1490 1495 1500 Ala Gly His Glu Ala Ser Gly Leu Val Thr Gly Ser Val Gly Ala Gly
5 1237058 六 、申請專利範圍 1505 1510 1515 1520 Gly Arg lie Gly Phe Val Phe Ser Gly Gin Gly Gly Gin Trp Leu Gly 1525 1530 1535 Met Gly Arg Gly Leu Tyr Arg Ala Phe Pro Val Phe Ala Ala Ala Phe 1540 1545 1550 Asp Glu Ala Cys Ala Glu Leu Asp Ala His Leu Gly Gin Glu lie Gly 1555 1560 1565 Val Arg Glu Val Val Ser Gly Ser Asp Ala Gin Leu Leu Asp Arg Thr 15 7 0 1575 1580 Leu Trp Ala Gin Ser Gly Leu Phe Ala Leu Gin Val Gly Leu Leu Lys 1585 1590 1595 1600 Leu Leu Asp Ser Trp Gly Val Arg Pro Ser Val Val Leu Gly His Ser 1605 1610 1615 Val Gly Glu Leu Ala Ala Ala Phe Ala Ala Gly Val Val Ser Leu Ser 1620 1625 1630 Gly Ala Ala Arg Leu Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu 1635 1640 1645 Pro Ser Gly Gly Gly Met Leu Ala Val Pro Ala Gly Glu Glu Leu Leu 1650 1655 1660 Trp Ser Leu Leu Ala Asp Gin Gly Asp Arg Val Gly lie Ala Ala Val 1665 1670 1675 1680 Asn Ala Ala Gly Ser Val Val Leu Ser Gly Asp Arg Asp Val Leu Asp 1685 1690 1695 Asp Leu Ala Gly Arg Leu Asp Gly Gin Gly lie Arg Ser Arg Trp Leu 1700 1705 1710 Arg Val Ser His Ala Phe His Ser Tyr Arg Met Asp Pro Met Leu Ala 1715 1720 1725 Glu Phe Ala Glu Leu Ala Arg Thr Val Asp Tyr Arg Arg Cys Glu Val 1730 1735 1740 Pro lie Val Ser Thr Leu Thr Gly Asp Leu Asp Asp Ala Gly Arg Met 1745 1750 1755 1760 Ser Gly Pro Asp Tyr Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe 1765 1770 1775 Ala Asp Gly Val Gin Ala Leu Val Glu His Asp Val Ala Thr Val Val 1780 1785 1790 Glu Leu Gly Pro Asp Gly Ala Leu Ser Ala Leu lie Gin Glu Cys Val 1795 1800 1805 Ala Ala Ser Asp His Ala Gly Arg Leu Ser Ala Val Pro Ala Met Arg 1810 1815 1820 Arg Asn Gin Asp Glu Ala Gin Lys Val Met Thr Ala Leu Ala His Val
-6 - 1237058 六 、申請專利範圍 1825 1830 1835 1840 His Val Arg Gly Gly Ala Val Asp Trp Arg Ser Phe Phe Ala Gly Thr 1845 1850 1855 Arg Ala Lys Gin He Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin Arg I860 1865 18 70 Tyr Trp Leu Asn Ala Leu Arg Glu Ser Ser Ala Gly Asp Met Gly Arg 18 75 1880 1885 Arg Val Glu Ala Lys Phe Trp Gly Ala Val Glu His Glu Asp Val Glu 1890 1895 1900 Ser Leu Ala Arg Val Leu Gly lie Val Asp Asp Gly Ala Ala Val Asp 1905 1910 1915 1920 Ser Leu Arg Ser Ala Leu Pro Val Leu Ala Gly Trp Gin Arg Thr Arg 1925 1930 1935 Thr Thr Glu Ser lie Met Asp Pro Arg Cys Tyr Arg lie Gly Trp Arg 1940 1945 1950 Gin Val Ala Gly Leu Pro Pro Met Gly Thr Val Phe Gly Thr Trp Leu 1955 1960 1965 Val Phe Ala Pro His Gly Trp Ser Ser Glu Pro Glu Val Val Asp Cys 1970 1975 1980 Val Thr Ala Leu Arg Ala Arg Gly Ala Ser Val Val Leu Val Glu Ala 1985 1990 1995 2000 Asp Pro Asp Pro Thr Ser Phe Gly Asp Arg Val Arg Thr Leu Cys Ser 2005 2010 2015 Gly Leu Pro Asp Leu Val Gly Val Leu Ser Met Leu Cys Leu Glu Glu 2020 2025 2030 Ser Val Leu Pro Gly Phe Ser Ala Val Ser Arg Gly Phe Ala Leu Thr 2035 2040 2045 Val Glu Leu Val Arg Val Leu Arg Ala Ala Gly Ala Thr Ala Arg Leu 2050 2055 2060 Trp Leu Leu Thr Cys Gly Gly Val Ser Val Gly Asp Val Pro Val Arg 2065 2070 2075 2080 Pro Ala Gin Ala Leu Ala Trp Gly Leu Gly Arg Val Val Gly Leu Glu 2085 2090 2095 His Pro Asp Trp Trp Gly Gly Leu lie Asp lie Pro Val Leu Phe Asp 2100 2105 2110 Glu Asp Ala Gin Glu Arg Leu Ser lie Val Leu Ala Gly Leu Asp Glu 2115 2120 2125 Asp Glu Val Ala lie Arg Pro Asp Gly Met Phe Ala Arg Arg Leu Val 2130 2135 2140 Arg His Thr Val Ser Ala Asp Val Lys Lys Ala Trp Arg Pro Arg Gly
7 1237058 六 、申請專利範圍 2145 2150 2155 2160 Ser Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Ala His Val Ala 2165 217 0 2175 Arg Trp Leu Ala Asp Ala Gly Ala Glu His Val Ala Met Val Ser Arg 2180 2185 2190 Arg Gly Glu Gin Ala Pro Ser Ala Glu Lys Leu Arg Thr Glu Leu Glu 2195 2200 2205 Asp Leu Gly Thr Arg Val Ser lie Val Ser Cys Asp Val Thr Asp Arg 2210 2215 2220 Glu Ala Leu Ala Glu Val Leu Lys Ala Leu Pro Ala Glu Asn Pro Leu 2225 2230 2235 2240 Thr Ala Val Val His Ala Ala Gly Val lie Glu Thr Gly Asp Ala Ala 2245 2250 2255 Ala Met Ser Leu Ala Asp Phe Asp His Val Leu Ser Ala Lys Val Ala 2260 2265 2270 Gly Ala Ala Asn Leu Asp Ala Leu Leu Ala Asp Val Glu Leu Asp Ala 2275 2280 2285 Phe Val Leu Phe Ser Ser Val Ser Gly Val Trp Gly Ala Gly Gly His 2290 2295 2300 Gly Ala Tyr Ala Ala Ala Asn Ala Tyr Leu Asp Ala Leu Ala Glu Gin 2305 2310 2315 2320 Arg Arg Ser Arg Gly Leu Val Ala Thr Ala Val Ala Trp Gly Pro Trp 2325 2330 2335 Ala Gly Glu Gly Met Ala Ser Gly Glu Thr Gly Asp Gin Leu Arg Arg 2340 2345 2350 Tyr Gly Leu Ser Pro Met Ala Pro Gin His Ala He Ala Gly lie Arg 2355 2360 2365 Gin Ala Val Glu Gin Asp Glu lie Ser Leu Val Val Ala Asp Val Asp 2370 2375 2380 Trp Ala Arg Phe Ser Ala Gly Leu Leu Ala Ala Arg Pro Arg Pro Leu 2385 2390 2395 2400 Leu Asn Glu Leu Ala Glu Val Lys Glu Leu Leu Val Asp Ala Gin Pro 2405 2410 2415 Glu Ala Gly Val Leu Ala Asp Ala Ser Leu Glu Trp Arg Gin Arg Leu 2420 2425 2430 Ser Ala Ala Pro Arg Pro Thr Gin Glu Gin Leu lie Leu Glu Leu Val 2435 2440 2445 Arg Gly Glu Thr Ala Leu Val Leu Gly His Pro Gly Ala Ala Ala Val 2450 2455 2460 Ala Ser Glu Arg Ala Phe Lys Asp Ser Gly Phe Asp Ser Gin Ala Ala
8 1237058 六 、申請專利範圍 2465 24 7 0 2475 2480 Val Glu Leu Arg Val Arg Leu Asn Arg Ala Thr Gly Leu Gin Leu Pro 2485 2490 2495 Ser Thr lie Ue Phe Ser His Pro Thr Pro Ala Glu Leu Ala Ala Glu 2500 2505 2510 Leu Arg Ala Arg Leu Leu Pro Glu Ser Ala Gly Ala Gly lie Pro Glu 2515 2520 2525 Glu Asp Glu Ala Arg lie Arg Ala Ala Leu Thr Ser lie Pro Phe Pro 2530 2535 2540 Ala Leu Arg Glu Ala Gly Leu Val Ser Pro Leu Leu Ala Leu Ala Gly 2545 2550 2555 2560 His Pro Val Asp Ser Gly lie Ser Ser Asp Asp Ala Ala Ala Thr Ser 2565 2570 2575 lie Asp Ala Met Asp Val Ala Gly Leu Val Glu Ala Ala Leu Gly Glu 2580 2585 2590 Arg Glu Ser 2595 序列辨識號碼:3 Met Thr Val Thr Thr Ser Tyr Glu Glu Val Val Glu Ala Leu Arg Ala 1 5 10 15 Ser Leu Lys Glu Asn Glu Arg Leu Arg Arg Gly Arg Asp Arg Phe Ser 20 25 30 Ala Glu Lys Asp Asp Pro lie Ala lie Val Ala Met Ser Cys Arg Tyr 35 40 45 Pro Gly Gin Val Ser Ser Pro Glu Asp Leu Trp Gin Leu Ala Ala Gly 50 55 60 Gly Val Asp Ala lie Ser Glu Val Pro Gly Asp Arg Gly Trp Asp Leu 65 70 75 80 Asp Gly Val Phe Val Pro Asp Ser Asp Arg Pro Gly Thr Ser Tyr Ala 85 90 95 Cys Ala Gly Gly Phe Leu Gin Gly Val Ser Glu Phe Asp Ala Gly Phe 100 105 110 Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin Arg 115 120 125 Leu Leu Leu Glu Val Ala Trp Glu Val Phe Glu Arg Ala Gly Leu Glu 130 135 140 Gin Arg Ser Thr Arg Gly Ser Arg Val Gly Val Phe Val Gly Thr Asn 145 150 155 160 Gly Gin Asp Tyr Ala Ser Trp Leu Arg Thr Pro Pro Pro Ala Val Ala 165 170 175 Gly His Val Leu Thr Gly Gly Ala Ala Ala Val Leu Ser Gly Arg Val
9 1237058 -Λ- /、 、申請專利範圍 180 185 190 Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala 195 200 205 Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gin Ala Leu Arg 210 215 220 Ala Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ser 225 230 235 240 Thr Pro Lys Val Phe Leu Glu Phe Ser Arg Gin Arg Gly Leu Ala Pro 245 250 255 Asp Gly Arg Cys Lys Ser Phe Ala Ala Gly Ala Asp Gly Thr Gly Trp 260 265 270 Gly Glu Gly Ala Gly Leu Leu Leu Leu Glu Arg Leu Ser Asp Ala Arg 275 280 285 Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Val Asn 290 295 300 Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Ser Ser Gin 305 310 315 320 Gin Arg Val lie Thr Gin Ala Leu Ala Ser Ala Gly Leu Ser Val Ser 325 330 335 Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp 340 345 350 Pro lie Glu Ala Gin Ala Leu He Ala Thr Tyr Gly Arg Asp Arg Asp 355 360 365 Pro Gly Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly His 3 70 375 380 Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val Met Ala 385 390 395 400 Met Arg His Gly Gin Leu Pro Arg Thr Leu His Val Glu Ser Pro Ser 405 410 415 Pro Glu Val Asp Trp Ser Ala Gly Thr Val Gin Leu Leu Thr Glu Asn 420 425 430 Thr Pro Trp Pro Arg Ser Gly Arg Val Arg Arg Val Gly Val Ser Ser 435 440 445 Phe Gly lie Ser Gly Thr Asn Ala His Val lie Leu Glu Gin Pro Pro 450 455 460 Gly Val Pro Ser Gin Ser Ala Gly Pro Gly Ser Gly Ser Val Val Asp 465 470 475 480 Val Pro Val Val Pro Trp Met Val Ser Gly Lys Thr Pro Glu Ala Leu 485 490 495 Ser Ala Gin Ala Thr Ala Leu Met Thr Tyr Leu Asp Glu Arg Pro Asp ίο
1237058 六 、申請專利範圍 500 505 510 Val Ser Ser Leu Asp Val Gly Tyr Ser Leu Ala Leu Thr Arg Ser Ala 515 520 525 Leu Asp Glu Arg Ala Val Val Leu Gly Ser Asp Arg Glu Thr Leu Leu 530 535 540 Cys Gly Val Lys Ala Leu Ser Ala Gly His Glu Ala Ser Gly Leu Val 545 550 555 560 Thr Gly Ser Val Gly Ala Gly Gly Arg lie Gly Phe Val Phe Ser Gly 565 570 575 Gin Gly Gly Gin Trp Leu Gly Met Gly Arg Gly Leu Tyr Arg Ala Phe 580 585 590 Pro Val Phe Ala Ala Ala Phe Asp Glu Ala Cys Ala Glu Leu Asp Ala 595 600 605 His Leu Gly Gin Glu lie Gly Val Arg Glu Val Val Ser Gly Ser Asp 610 615 620 Ala Gin Leu Leu Asp Arg Thr Leu Trp Ala Gin Ser Gly Leu Phe Ala 625 630 635 640 Leu Gin Val Gly Leu Leu Lys Leu Leu Asp Ser Trp Gly Val Arg Pro 645 650 655 Ser Val Val Leu Gly His Ser Val Gly Glu Leu Ala Ala Ala Phe Ala 660 665 670 Ala Gly Val Val Ser Leu Ser Gly Ala Ala Arg Leu Val Ala Gly Arg 6 75 680 685 Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Gly Met Leu Ala Val 690 695 700 Pro Ala Gly Glu Glu Leu Leu Trp Ser Leu Leu Ala Asp Gin Gly Asp 705 710 715 720 Arg Val Gly lie Ala Ala Val Asn Ala Ala Gly Ser Val Val Leu Ser 725 730 735 Gly Asp Arg Asp Val Leu Asp Asp Leu Ala Gly Arg Leu Asp Gly Gin 740 745 750 Gly lie Arg Ser Arg Trp Leu Arg Val Ser His Ala Phe His Ser Tyr 755 760 765 Arg Met Asp Pro Met Leu Ala Glu Phe Ala Glu Leu Ala Arg Thr Val 77 0 775 780 Asp Tyr Arg Arg Cys Glu Val Pro He Val Ser Thr Leu Thr Gly Asp 785 790 795 800 Leu Asp Asp Ala Gly Arg Met Ser Gly Pro Asp Tyr Trp Val Arg Gin 805 810 815 Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Gin Ala Leu Val Glu
1237058 六 、申請專利範圍 820 825 830 His Asp Val Ala Thr Val Val Glu Leu Gly Pro Asp Gly Ala Leu Ser 835 840 845 Ala Leu lie Gin Glu Cys Val Ala Ala Ser Asp His Ala Gly Arg Leu 850 855 860 Ser Ala Val Pro Ala Met Arg Arg Asn Gin Asp Glu Ala Gin Lys Val 865 870 8 75 880 Met Thr Ala Leu Ala His Val His Val Arg Gly Gly Ala Val Asp Trp 885 890 895 Arg Ser Phe Phe Ala Gly Thr Gly Ala Lys Gin lie Glu Leu Pro Thr 900 905 910 Tyr Ala Phe Gin Arg Gin Arg Tyr Trp Leu Val Pro Ser Asp Ser Gly 915 920 925 Asp Val Thr Gly Ala Gly Leu Ala Gly Ala Glu His Pro Leu Leu Gly 930 935 940 Ala Val Val Pro Val Ala Gly Gly Asp Glu Val Leu Leu Thr Gly Arg 945 950 955 960 He Ser Val Arg Thr His Pro Trp Leu Ala Glu His Arg Val Leu Gly 965 97 0 975 Glu Val lie Val Ala Gly Thr Ala Leu Leu Glu lie Ala Leu His Ala 980 985 990 Gly Glu Arg Leu Gly Cys Glu Arg Val Glu Glu Leu Thr Leu Glu Ala 995 1000 1005 Pro Leu Val Leu Pro Glu Arg Gly Ala lie Gin Val Gin Leu Arg Val 1010 1015 1020 Gly Ala Pro Glu Asn Ser Gly Arg Arg Pro Met Ala Leu Tyr Ser Arg 1025 1030 1035 1040 Pro Glu Gly Ala Ala Glu His Asp Trp Thr Arg His Ala Thr Gly Arg 1045 1050 1055 Leu Ala Pro Gly Arg Gly Glu Ala Ala Gly Asp Leu Ala Asp Trp Pro 1060 1065 1070 Ala Pro Gly Ala Leu Pro Val Asp Leu Asp Glu Phe Tyr Arg Asp Leu 1075 1080 1085 Ala Glu Leu Gly Leu Glu Tyr Gly Pro lie Phe Gin Gly Leu Lys Ala 1090 1095 1100 Ala Trp Arg Gin Gly Asp Glu Val Tyr Ala Glu Ala Ala Leu Pro Gly 1105 1110 1115 1120 Thr Glu Asp Ser Gly Phe Gly Val His Pro Ala Leu Leu Asp Ala Ala 1125 1130 1135 Leu His Ala Thr Ala Val Arg Asp Met Asp Asp Ala Arg Leu Pro Phe
1237058 六 、申請專利範圍 1140 1145 1150 Gin Trp Glu Gly Val Ser Leu His Ala Lys Ala Ala Pro Ala Leu Arg 1155 1160 1165 Val Arg Val Val Pro Ala Gly Asp Asp Ala Lys Ser Leu Leu Val Cys 1170 1175 1180 Asp Gly Thr Gly Arg Pro Val lie Ser Val Asp Arg Leu Val Leu Arg 1185 1190 1195 1200 Ser Ala Ala Ala Arg Arg Thr Gly Ala Arg Arg Gin Ala His Gin Ala 1205 1210 1215 Arg Leu Tyr Arg Leu Ser Trp Pro Thr Val Gin Leu Pro Thr Ser Ala 1220 1225 1230 Gin Pro Pro Ser Cys Val Leu Leu Gly Thr Ser Glu Val Ser Ala Asp 1235 1240 1245 lie Gin Val Tyr Pro Asp Leu Arg Ser Leu Thr Ala Ala Leu Asp Ala 1250 1255 1260 Gly Ala Glu Pro Pro Gly Val Val lie Ala Pro Thr Pro Pro Gly Gly 1265 1270 12 75 1280 Gly Arg Thr Ala Asp Val Arg Glu Thr Thr Arg His Ala Leu Asp Leu 1285 1290 1295 Val Gin Gly Trp Leu Ser Asp Gin Arg Leu Asn Glu Ser Arg Leu Leu 1300 1305 1310 Leu Val Thr Gin Gly Ala Val Ala Val Glu Pro Gly Glu Pro Val Thr 1315 1320 1325 Asp Leu Ala Gin Ala Ala Leu Trp Gly Leu Leu Arg Ser Thr Gin Thr 1330 1335 1340 Glu His Pro Asp Arg Phe Val Leu Val Asp Val Pro Glu Pro Ala Gin 1345 1350 1355 1360 Leu Leu Pro Ala Leu Pro Gly Val Leu Ala Cys Gly Glu Pro Gin Leu 1365 1370 1375 Ala Leu Arg Arg Gly Gly Ala His Ala Pro Arg Leu Ala Gly Leu Gly 1380 1385 1390 Ser Asp Asp Val Leu Pro Val Pro Asp Gly Thr Gly Trp Arg Leu Glu 1395 1400 1405 Ala Thr Arg Pro Gly Ser Leu Asp Gly Leu Ala Leu Val Asp Glu Pro 1410 1415 1420 Thr Ala Thr Ala Pro Leu Gly Asp Gly Glu Val Arg lie Ala Met Arg 1425 1430 1435 1440 Ala Ala Gly Val Asn Phe Arg Asp Ala Leu lie Ala Leu Gly Met Tyr 1445 1450 1455 Pro Gly Val Ala Ser Leu Gly Ser Glu Gly Ala Gly Val Val Val Glu
1237058 六 、申請專利範圍 1460 1465 1470 Thr Gly Pro Gly Val Thr Gly Leu Ala Pro Gly Asp Arg Val Met Gly 1475 1480 1485 Met He Pro Lys Ala Phe Gly Pro Leu Ala Val Ala Asp His Arg Met 1490 1495 1500 Val Thr Arg lie Pro Ala Gly Trp Ser Phe Ala Arg Ala Ala Ser Val 1505 1510 1515 1520 Pro lie Val Phe Leu Thr Ala Tyr Tyr Ala Leu Val Asp Leu Ala Gly 1525 1530 1535 Leu Arg Pro Gly Glu Ser Leu Leu Val His Ser Ala Ala Gly Gly Val 1540 1545 1550 Gly Met Ala Ala lie Gin Leu Ala Arg His Leu Gly Ala Glu Val Tyr 1555 1560 1565 Ala Thr Ala Ser Glu Asp Lys Trp Gin Ala Val Glu Leu Ser Arg Glu 1570 1575 1580 His Leu Ala Ser Ser Arg Thr Cys Asp Phe Glu Gin Gin Phe Leu Gly 1585 1590 1595 1600 Ala Thr Gly Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Ala Gly 1605 1610 1615 Glu Phe Ala Asp Ala Ser Leu Arg Met Leu Pro Arg Gly Gly Arg Phe 1620 1625 1630 Leu Glu Leu Gly Lys Thr Asp Val Arg Asp Pro Val Glu Val Ala Asp 1635 1640 1645 Ala His Pro Gly Val Ser Tyr Gin Ala Phe Asp Thr Val Glu Ala Gly 1650 1655 1660 Pro Gin Arg He Gly Glu Met Leu His Glu Leu Val Glu Leu Phe Glu 1665 1670 1675 1680 Gly Arg Val Leu Glu Pro Leu Pro Val Thr Ala Trp Asp Val Arg Gin 1685 1690 1695 Ala Pro Glu Ala Leu Arg His Leu Ser Gin Ala Arg His Val Gly Lys 1700 1705 1710 Leu Val Leu Thr Met Pro Pro Val Trp Asp Ala Ala Gly Thr Val Leu 1715 1720 1725 Val Thr Gly Gly Thr Gly Ala Leu Gly Ala Glu Val Ala Arg His Leu 1730 1735 1740 Val lie Glu Arg Gly Val Arg Asn Leu Val Leu Val Ser Arg Arg Gly 1745 1750 1755 1760 Pro Ala Ala Ser Gly Ala Ala Glu Leu Val Ala Gin Leu Thr Ala Tyr 1765 1770 1775 Gly Ala Glu Val Ser Leu Gin Ala Cys Asp Val Ala Asp Arg Glu Thr
1237058 六 、申請專利範圍 1780 1785 1790 Leu Ala Lys Val Leu Ala Ser lie Pro Asp Glu His Pro Leu Thr Ala 1795 1800 1805 Val Val His Ala Ala Gly Val Leu Asp Asp Gly Val Ser Glu Ser Leu 1810 1815 1820 Thr Val Glu Arg Leu Asp Gin Val Leu Arg Pro Lys Val Asp Gly Ala 1825 1830 1835 1840 Arg Asn Leu Leu Glu Leu lie Asp Pro Asp Val Ala Leu Val Leu Phe 1845 1850 1855 Ser Ser Val Ser Gly Val Leu Gly Ser Gly Gly Gin Gly Asn Tyr Ala 1860 1865 1870 Ala Ala Asn Ser Phe Leu Asp Ala Leu Ala Gin Gin Arg Gin Ser Arg 1875 1880 1885 Gly Leu Pro Thr Arg Ser Leu Ala Trp Gly Pro Trp Ala Glu His Gly 1890 1895 1900 Met Ala Ser Thr Leu Arg Glu Ala Glu Gin Asp Arg Leu Ala Arg Ser 1905 1910 1915 1920 Gly Leu Leu Pro lie Ser Thr Glu Glu Gly Leu Ser Gin Phe Asp Ala 1925 1930 1935 Ala Cys Gly Gly Ala His Thr Val Val Ala Pro Val Arg Phe Ser Arg 1940 1945 1950 Leu Ser Asp Gly Asn Ala lie Lys Phe Ser Val Leu Gin Gly Leu Val 1955 I960 1965 Gly Pro His Arg Val Asn Lys Ala Ala Thr Ala Asp Asp Ala Glu Ser 1970 1975 1980 Leu Arg Lys Arg Leu Gly Arg Leu Pro Asp Ala Glu Gin His Arg lie 1985 1990 1995 2000 Leu Leu Asp Leu Val Arg Met His Val Ala Ala Val Leu Gly Phe Ala 2005 2010 2015 Gly Ser Gin Glu lie Thr Ala Asp Gly Thr Phe Lys Val Leu Gly Phe 2020 2025 2030 Asp Ser Leu Thr Val Val Glu Leu Arg Asn Arg lie Asn Gly Ala Thr 2035 2040 2045 Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asn Tyr Pro Thr Pro Asp 2050 2055 2060 Ala Leu Ala Ala His Leu Val Thr Ala Leu Ser Ala Asp Arg Leu Ala 2065 2070 2075 2080 Gly Thr Phe Glu Glu Leu Asp Arg Trp Ala Ala Asn Leu Pro Thr Leu 2085 2090 2095 Ala Arg Asp Glu Ala Thr Arg Ala Gin lie Thr Thr Arg Leu Gin Ala
15 1237058 六 、申請專利範圍 2100 2105 2110 lie Leu Gin Ser Leu Ala Asp Val Ser Gly Gly Thr Gly Gly Gly Ser 2115 2120 2125 Val Pro Asp Arg Leu Arg Ser Ala Thr Asp Asp Glu Leu Phe Gin Leu 2130 2135 2140 Leu Asp Asn Asp Leu Glu Leu Pro 2145 2150 序列辨識號碼:4 Met Ser Asn Glu Glu Lys Leu Arg Glu Tyr Leu Arg Arg Ala Leu Val 1 5 10 15 Asp Leu His Gin Ala Arg Glu Arg Leu His Glu Ala Glu Ser Gly Glu 20 25 30 Arg Glu Pro lie Ala lie Val Ala Met Gly Cys Arg Tyr Pro Gly Gly 35 40 45 Val Gin Asp Pro Glu Gly Leu Trp Lys Leu Val Ala Ser Gly Gly Asp 50 55 60 Ala lie Gly Glu Phe Pro Ala Asp Arg Gly Trp His Leu Asp Glu Leu 65 70 75 80 Tyr Asp Pro Asp Pro Asp Gin Pro Gly Thr Cys Tyr Thr Arg His Gly 85 90 95 Gly Phe Leu His Asp Ala Gly Glu Phe Asp Ala Gly Phe Phe Asp lie 100 105 110 Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin Arg Leu Leu Leu 115 120 125 Glu lie Ser Trp Glu Thr Val Glu Ser Ala Gly Met Asp Pro Arg Ser 130 135 140 Leu Arg Gly Ser Arg Thr Gly Val Phe Ala Gly Leu Met Tyr Glu Gly 145 150 155 160 Tyr Asp Thr Gly Ala His Arg Ala Gly Glu Gly Val Glu Gly Tyr Leu 165 170 175 Gly Thr Gly Asn Ala Gly Ser Val Ala Ser Gly Arg Val Ala Tyr Ala 180 185 190 Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser 195 200 205 Ser Leu Val Ala Leu His Leu Ala Cys Gin Ser Leu Arg Gin Gly Glu 210 215 220 Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ser Thr Pro Glu 225 230 235 240 Arg Phe Val Glu Phe Ser Arg Gin Arg Gly Leu Ala Pro Asp Gly Arg 245 250 255 Cys Lys Ser Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Gly Glu Gly
1237058 六 、申請專利範圍 260 265 2 70 Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly 2 75 280 285 His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gin Asp Gly 290 295 300 Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Leu Ala Gin Glu Arg Val 305 310 315 320 lie Gin Gin Val Leu Thr Ser Ala Gly Leu Ser Ala Ser Asp Val Asp 325 330 335 Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro lie Glu 340 345 350 Ala Gin Ala Leu lie Ala Ala Tyr Gly Gin Asp Arg Asp Arg Asp Arg 355 360 365 Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly His Thr Gin Ala 370 375 380 Ala Ala Gly Val Ala Gly Val lie Lys Met Val Met Ala Met Arg His 385 390 395 400 Gly Glu Leu Pro Arg Thr Leu His Val Asp Glu Pro Asn Ser His Val 405 410 415 Asp Trp Ser Ala Gly Ala Val Arg Leu Leu Thr Glu Asn lie Arg Trp 420 425 430 Pro Gly Thr Gly Thr Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser 435 440 445 Gly Thr Asn Ala His Val lie Leu Glu His Asp Pro Leu Ala Val Thr 450 455 460 Glu Asn Glu Glu Ala Ala Gin Ser Pro Ala Pro Gly lie Val Pro Trp 465 470 475 480 Ala Leu Ser Gly Arg Ser Ser Thr Ala Leu Arg Ala Gin Ala Glu Arg 485 490 495 Leu Arg Glu Leu Cys Glu Gin Thr Asp Pro Asp Pro Val Asp Val Gly 500 505 510 Phe Ser Leu Ala Ala Thr Arg Thr Ala Trp Glu His Arg Ala Val Val 515 520 525 Leu Gly Arg Asp Ser Ala Thr Leu Arg Ser Gly Leu Gly Val Val Ala 530 535 540 Ser Gly Glu Pro Ala Val Asp Val Val Glu Gly Ser Val Leu Asp Gly 545 550 555 560 Glu Val Val Phe Val Phe Pro Gly Gin Gly Trp Gin Trp Ala Gly Met 565 570 575 Ala Val Asp Leu Leu Asp Ala Ser Pro Thr Phe Ala Arg His Met Asp
17 1237058 六 、申請專利範圍 580 585 590 Glu Cys Ala Thr Ala Leu Arg Arg Tyr Val Asp Trp Ser Leu Val Asp 595 600 605 Val Leu Arg Gly Ala Glu Asn Ser Pro Pro Leu Asp Arg Val Asp Val 610 615 620 Leu Gin Pro Ala Ser Phe Ala Val Met Val Ser Leu Ala Glu Val Trp 625 630 635 640 Arg Ser Tyr Gly Val Arg Pro Ala Ala Val Val Gly His Ser Gin Gly 645 650 655 Glu lie Ala Ala Ala Cys Ala Ala Gly Val Leu Pro Leu Glu Asp Ala 660 665 670 Ala Arg Leu Val Ala Leu Arg Ser Arg Ala Leu Lys Gly Leu Ser Gly 675 680 685 Arg Gly Gly Met Ala Ser Leu Ala Cys Pro Ala Asp Glu Val Ala Ala 690 695 700 Leu Phe Ala Gly Ser Gly Gly Arg Leu Glu Val Ala Ala lie Asn Gly 705 710 715 720 Pro Arg Ser Val Val Val Ser Gly Asp Leu Glu Ala Val Asp Glu Leu 725 730 735 Leu Ala Glu Cys Ala Glu Lys Asp Met Arg Ala Arg Arg lie Pro Val 740 745 750 Asp Tyr Ala Ser His Ser Ala His Val Glu Val Val Arg Ser Pro Val 755 760 765 Leu Ala Ala Ala Ala Gly Val Arg His Arg Asp Gly Gin Val Pro Trp 77 0 775 780 Trp Ser Thr Val lie Gly Asp Trp Val Asp Pro Ala Arg Leu Asp Gly 785 790 7 95 800 Glu Tyr Trp Tyr Arg Asn Leu Arg Gin Pro Val Arg Phe Glu His Ala 805 810 815 Val Gin Gly Leu Val Glu Arg Gly Phe Gly Leu Phe lie Glu Met Ser 820 825 830 Ala His Pro Val Leu Thr Thr Ala Val Glu Glu Thr Gly Ala Glu Ser 835 840 845 Glu Thr Ala Val Ala Ala Val Gly Thr Leu Arg Arg Asp Ser Gly Gly 850 855 860 Leu Arg Arg Leu Leu His Ser Leu Ala Glu Ala Tyr Val Arg Gly Ala 865 870 875 880 Thr Val Asp Trp Ala Val Ala Phe Gly Gly Ala Gly Arg Arg Leu Asp 885 890 895 Leu Pro Thr Tyr Pro Phe Gin Arg Gin Arg Tyr Trp Leu Asp Lys Gly 18 1237058 六 、申請專利範圍 900 905 910 Ala Ala Ser Asp Glu Ala Arg Ala Val Ser Asp Pro Ala Ala Gly Trp 915 920 925 Phe Trp Gin Ala Val Ala Arg Gin Asp Leu Lys Ser Val Ser Asp Ala 930 935 940 Leu Asp Leu Asp Ala Asp Ala Pro Leu Ser Ala Thr Leu Pro Ala Leu 945 950 955 960 Ser Val Trp His Arg Gin Glu Arg Glu Arg Val Leu Ala Asp Gly Trp 965 970 975 Arg Tyr Arg Val Asp Trp Val Arg Val Ala Pro Gin Pro Val Arg Arg 980 985 990 Thr Arg Glu Thr Trp Leu Leu Val Val Pro Pro Gly Gly lie Glu Glu 995 1000 1005 Ala Leu Val Glu Arg Leu Thr Asp Ala Leu Asn Thr Arg Gly lie Ser 1010 1015 1020 Thr Leu Arg Leu Asp Val Pro Pro Ala Ala Thr Ser Gly Glu Leu Ala 1025 1030 1035 1040 Thr Glu Leu Arg Ala Ala Ala Asp Gly Asp Pro Val Lys Ala lie Leu 1045 1050 1055 Ser Leu Thr Ala Leu Asp Glu Arg Pro His Pro Glu Cys Lys Asp Val 1060 1065 1070 Pro Ser Gly lie Ala Leu Leu Leu Asn Leu Val Lys Ala Leu Gly Glu 1075 1080 1085 Ala Asp Leu Arg lie Pro Leu Trp Thr lie Thr Arg Gly Ala Val Lys 1090 1095 1100 Ala Gly Pro Ala Asp Arg Leu Leu Arg Pro Met Gin Ala Gin Ala Trp 1105 1110 1115 1120 Gly Leu Gly Arg Val Ala Ala Leu Glu His Pro Glu Arg Trp Gly Gly 1125 1130 1135 Leu lie Asp Leu Pro Asp Ser Leu Asp Gly Asp Val Leu Thr Arg Leu 1140 1145 1150 Gly Glu Ala Leu Thr Asn Gly Leu Ala Glu Asp Gin Leu Ala lie Arg 1155 1160 1165 Gin Ser Gly Val Leu Ala Arg Arg Leu Val Pro Ala Pro Ala Asn Gin 1170 1175 1180 Pro Ala Gly Arg Lys Trp Arg Pro Arg Gly Ser Ala Leu lie Thr Gly 1185 1190 1195 1200 Gly Leu Gly Ala Val Gly Ala Gin Val Ala Arg Trp Leu Ala Glu lie 1205 1210 1215 Gly Ala Glu Arg lie Val Leu Thr Ser Arg Arg Gly Asn Gin Ala Ala
19 1237058 六 、申請專利範圍 1220 1225 1230 Gly Ala Ala Glu Leu Glu Ala Glu Leu Arg Ala Leu Gly Ala Gin Val 1235 1240 1245 Ser He Val Ala Cys Asp Val Thr Asp Arg Ala Glu Met Ser Ala Leu 1250 1255 1260 Leu Ala Glu Phe Asp Val Thr Ala Val Phe His Ala Ala Gly Val Gly 1265 1270 1275 1280 Arg Leu Leu Pro Leu Ala Glu Thr Asp Gin Asn Gly Leu Ala Glu lie 1285 1290 1295 Cys Ala Ala Lys Val Arg Gly Ala Gin Val Leu Asp Glu Leu Cys Asp 1300 1305 1310 Ser Thr Asp Leu Asp Ala Phe Val Leu Phe Ser Ser Gly Ala Gly Val 1315 1320 1325 Trp Gly Gly Gly Gly Gin Gly Ala Tyr Gly Ala Ala Asn Ala Phe Leu 1330 1335 1340 Asp Thr Leu Ala Glu Gin Arg Arg Ala Arg Gly Leu Pro Ala Thr Ser 1345 1350 1355 1360 He Ser Trp Gly Ser Trp Ala Gly Gly Gly Met Ala Asp Gly Ala Ala 1365 1370 1375 Gly Glu His Leu Arg Arg Arg Gly lie Arg Pro Met Pro Ala Ala Ser 1380 1385 1390 Ala lie Leu Ala Leu Gin Glu Val Leu Asp Gin Asp Glu Thr Cys Val 1395 1400 1405 Ser lie Ala Asp Val Asp Trp Asp Arg Phe Val Pro Thr Phe Ala Ala 1410 1415 1420 Thr Arg Ala Thr Arg Leu Phe Asp Glu Val Pro Ala Ala Arg Lys Ala 1425 1430 1435 1440 Met Pro Ala Asn Gly Pro Ala Glu Pro Gly Gly Ser Pro Phe Ala Arg 1445 1450 1455 Asn Leu Ala Glu Leu Pro Glu Ala Gin Arg Arg His Glu Leu Val Asp 1460 1465 1470 Leu Val Cys Ala Gin Val Ala Thr Val Leu Gly His Gly Ser Arg Glu 14 75 1480 1485 Glu Val Gin Pro Glu Arg Ala Phe Arg Ala Leu Gly Phe Asp Ser Leu 1490 1495 1500 Met Ala Val Asp Leu Arg Asn Arg Leu Thr Thr Ala Thr Gly Leu Arg 1505 1510 1515 1520 Leu Pro Thr Thr Thr Val Phe Asp Tyr Pro Asn Pro Ala Ala Leu Ala 1525 1530 1535 Ala His Leu Leu Glu Glu Leu Val Gly Asp Val Ala Ser Ala Ala Val
20 1237058 -A-/ \ 、申請專利範圍 1540 1545 1550 Thr Ala Ala Ser Ala Pro Ala Ser Asp Glu Pro lie Ala lie Val Ala 1555 1560 1565 Met Ser Cys Arg Phe Pro Gly Gly Ala His Ser Pro Glu Asp Leu Trp 1570 1575 1580 Arg Leu Val Ala Ala Gly Thr Glu Val lie Gly Glu Phe Pro Ser Asp 1585 1590 1595 1600 Arg Gly Trp Asp Ala Glu Gly Leu Tyr Asp Pro Asp Ala Ser Arg Pro 1605 1610 1615 Gly Thr Thr Tyr Ala Arg Met Ala Gly Phe Leu Tyr Asp Ala Gly Glu 1620 1625 1630 Phe Asp Ala Asp Leu Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met 1635 1640 1645 Asp Pro Gin Gin Arg Leu Val Leu Glu lie Ala Trp Glu Ala Leu Glu 1650 1655 1660 Arg Ala Gly lie Asp Pro Leu Ser Leu Lys Gly Ser Gly Val Gly Thr 1665 1670 1675 1680 Tyr lie Gly Ala Gly Ser Arg Gly Tyr Ala Thr Asp Val Arg Gin Phe 1685 1690 1695 Pro Glu Glu Ala Glu Gly Tyr Leu Leu Thr Gly Thr Ser Ala Ser Val 1700 1705 1710 Leu Ser Gly Arg Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val 1715 1720 1725 Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 1730 1735 1740 Cys Gin Ser Leu Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly 1745 1750 1755 1760 Val Thr Val Met Ser Thr Pro Glu Met Phe Val Glu Phe Ser Arg Gin 1765 1770 17 75 Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ala Glu Ser Ala 1780 1785 1790 Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Leu Leu Leu Leu Glu Arg 1795 1800 1805 Leu Ser Asp Ala His Arg Asn Gly His Arg Val Leu Ala Val Val Arg 1810 1815 1820 Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn Gly Leu Ala Ala Pro 1825 1830 1835 1840 Asn Gly Pro Ser Gin Gin Arg Val lie Asn Gin Ala Leu Ala Asn Ala 1845 1850 1855 Ala Leu Ser Ala Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly
21 1237058 六 、申請專利範圍 1860 1865 1870 Thr Arg Leu Gly Asp Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr 1875 1880 1885 Gly Gin Ala Arg Glu Arg Asp Arg Pro Leu Trp Leu Gly Ser Val Lys 1890 1895 1900 Ser Asn He Gly His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie 1905 1910 1915 1920 Lys Met Val Met Ala Met Arg His Gly Gin Leu Pro Ala Ser Leu His 1925 1930 1935 Ala Asp Glu Pro Thr Ser Glu Val Asp Trp Ser Ser Gly Ala Val Arg 1940 1945 1950 Leu Leu Ala Glu Gin Val Pro Trp Pro Glu Ser Asp Arg Val Arg Arg 1955 1960 1965 Val Gly Val Ser Ser Phe Gly lie Ser Gly Thr Asn Ala His Val lie 1970 1975 1980 Leu Glu Gin Ala Thr Asn Ala Pro Asp Ser Thr Ala Glu Thr Asp Lys 1985 1990 1995 2000 Thr Glu Ser Gly Ser Thr Val Asp lie Pro Val Val Pro Trp Leu Val 2005 2010 2015 Ser Gly Lys Thr Thr Asp Ser Leu Arg Gly Gin Ala Glu Arg Val Leu 2020 2025 2030 Ser Gin Val Glu Ser Arg Pro Glu Gin Arg Ser Leu Asp Val Ala Tyr 2035 2040 2045 Ser Leu Ala Ser Gly Arg Ala Ala Leu Asp Glu Arg Ala Val Val Leu 2050 2055 2060 Gly Ala Asp Arg Gly Glu Leu Val Ala Gly Leu Ala Ala Leu Ala Ala 2065 2070 2075 2080 Gly Gin Glu Ala Ser Gly Val lie Ser Gly Thr Arg Ala Ser Ala Arg 2085 2090 2095 Phe Gly Phe Val Phe Ser Gly Gin Gly Gly Gin Trp Leu Gly Met Gly 2100 2105 2110 Arg Ala Leu Tyr Ser Lys Phe Pro Val Phe Ala Ala Ala Phe Asp Glu 2115 2120 2125 Ala Cys Ala Glu Leu Glu Ala His Leu Gly Glu Asp Arg Arg Val Arg 2130 2135 2140 Asp Val Val Phe Gly Ser Asp Ala Gin Leu Leu Asp Gin Thr Leu Trp 2145 2150 2155 2160 Ala Gin Ser Gly Leu Phe Ala Leu Gin Ala Gly Leu Leu Gly Leu Leu 2165 2170 2175 Gly Ser Trp Gly Val Arg Pro Asp Val Val Met Gly His Ser Val Gly
1237058 六 、申請專利範圍 2180 2185 2190 Glu Leu Ala Ala Ala Phe Ala Ala Gly Val Leu Ser Leu Arg Asp Ala 2195 2200 2205 Ala Arg Leu Val Ala Ala Arg Ala Arg Leu Met Gin Ala Leu Pro Ser 2210 2215 2220 Asp Gly Ala Met Leu Ala Val Ala Ala Gly Glu Asp Leu Val Arg Pro 2225 2230 2235 2240 Leu Leu Ala Gly Arg Glu Glu Ser Val Ser Val Ala Ala Leu Asn Ala 2245 2250 2255 Pro Gly Ser Val Val Leu Ser Gly Asp Arg Glu Val Leu Ala Ser lie 2260 2265 2270 Val Gly Arg Leu Thr Glu Leu Arg Val Arg Thr Arg Arg Leu Arg Val 2275 2280 2285 Ser His Ala Phe His Ser His Arg Met Asp Pro Met Leu Gly Glu Phe 2290 2295 2300 Ala Gin lie Ala Glu Ser Ala Glu Phe Gly Lys Pro Thr Thr Pro Leu 2305 2310 2315 2320 Val Ser Thr Leu Thr Gly Glu Leu Asp Arg Ala Ala Glu Met Ser Thr 2325 2330 2335 Pro Gly Tyr Trp Val Arg Gin Ala Arg Glu Pro Val Arg Phe Ala Asp 2340 2345 2350 Gly Val Gin Ala Leu Ala Ala Gin Gly lie Gly Thr Val Val Glu Leu 2355 2360 2365 Gly Pro Asp Gly Thr Leu Ala Ala Leu Val Arg Glu Cys Ala Thr Glu 23 7 0 23 75 2380 Ser Asp Arg Val Gly Arg lie Ser Ser lie Pro Leu Met Arg Arg Glu 2385 2390 2395 2400 Arg Asp Glu Thr Arg Ser Val Met Thr Ala Leu Ala His Leu His Thr 2405 2410 2415 Arg Gly Gly Glu Val Asp Trp Gin Ala Phe Phe Ala Gly Thr Gly Ala 2420 2425 2430 Arg Gin Leu Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin His Tyr Trp 2435 2440 2445 lie Glu Ser Ser Ala Arg Pro Ala Arg Asp Arg Ala Asp lie Gly Glu 2450 2455 2460 Val Ala Glu Gin Phe Trp Thr Ala Val Asp Gin Gly Asp Leu Ala Thr 2465 2470 2475 2480 Leu Val Ala Ala Leu Asp Leu Gly Ala Asp Asp Asp Thr Cys Ala Ser 2485 2490 2495 Leu Ser Asp Val Leu Pro Ala Leu Ser Ser Trp Arg Ser Gly Leu Arg
23 1237058 六 、申請專利範圍 2500 2505 2510 Asn Arg Ser Leu Val Asp Ser Cys Arg Tyr Arg lie Ser Trp His Ser 2515 2520 2525 Ser Arg Glu Val Pro Ala Pro Lys lie Ser Gly Thr Trp Leu Leu Val 2530 2535 2540 Val Pro Gly Ala Ala Asp Asp Gly Leu Val Thr Ala Leu Thr Ser Ser 2545 2550 2555 2560 Leu Val Gly Gly Gly Ala Glu Val Val Arg lie Gly Leu Ser Glu Glu 2565 2570 2575 Asp Pro His Arg Glu Asp Val Ala Gin Arg Leu Ala Asn Ala Leu Thr 2580 2585 2590 Asp Ala Gly Gin Leu Gly Gly Val Leu Ser Leu Leu Gly Leu Asp Glu 2595 2600 2605 Ser Pro Ala Pro Gly Phe Ser Cys Leu Pro Thr Gly Phe Ala Leu Thr 2610 2615 2620 Val Gin Leu Leu Arg Ala Leu Arg Lys Ala Asp Val Glu Ala Pro Phe 2625 2630 2635 2640 Trp Ala Val Thr Arg Gly Gly Val Ala Leu Glu Asp Val Arg Val Ser 2645 2650 2655 Pro Glu Gin Ala Leu Val Trp Gly Leu Leu Arg Val Ala Gly Leu Glu 2660 2665 2670 His Pro Glu Phe Trp Gly Gly Leu lie Asp Leu Pro Ser Asp Trp Asp 2675 2680 2685 Asp Arg Leu Gly Ala Arg Leu Ala Gly Val Leu Ala Asp Gly Gly Glu 2690 2695 2700 Asp Gin Val Ala lie Arg Arg Gly Gly Val Phe Val Arg Arg Leu Glu 2705 2710 2715 2720 Arg Ala Gly Ala Ser Gly Ala Gly Ser Val Trp Arg Pro Arg Gly Thr 2725 2730 2735 Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Ala His Val Ala Arg 2740 2745 2750 Trp Leu Ala Gly Ala Gly Ala Glu His Val Val Leu Thr Ser Arg Arg 2755 2760 2 765 Gly Ala Asp Ala Pro Gly Ala Gly Glu Leu Arg Ala Glu Leu Glu Ala 2770 2 775 2780 Leu Gly Ala Arg Val Ser lie Val Pro Cys Asp Val Ala Asp Arg Asp 2785 2790 2795 2800 Ala Val Ala Gly Val Leu Ala Gly lie Gly Gly Glu Cys Pro Leu Thr 2805 2810 2815 Ala Val Val His Ala Ala Gly Val Gly Glu Ala Gly Asp Val Val Glu 1237058 六 、申請專利範圍 2820 2825 2830 Met Gly Leu Ala Asp Phe Ala Ala Val Leu Ser Ala Lys Val Arg Gly 2835 2840 2845 Ala Ala Asn Leu Asp Glu Leu Leu Ala Asp Ser Glu Leu Asp Ala Phe 2850 2855 2860 Val Met Phe Ser Ser Val Ser Gly Val Trp Gly Ala Gly Gly Gin Gly 2865 2870 2875 2880 Ala Tyr Ala Ala Ala Asn Ala Tyr Leu Asp Ala Leu Ala Glu Gin Arg 2885 2890 2895 Arg Ala Arg Gly Leu Val Gly Thr Ala Val Ala Trp Gly Pro Trp Ala 2900 2905 2910 Gly Asp Gly Met Ala Ala Gly Glu Thr Gly Ala Gin Leu His Arg Met 2915 2920 2925 Gly Leu Ala Ser Met Glu Pro Ser Ala Ala Leu Leu Ala Leu Gin Gly 2930 2935 2940 Ala Leu Asp Arg Asp Glu Thr Ser Leu Val Val Ala Asp Val Asp Trp 2945 2950 2955 2960 Ala Arg Phe Ala Pro Ala Phe Thr Ser Ala Arg Arg Arg Pro Leu Leu 2965 2970 2975 Asp Thr lie Asp Glu Ala Arg Ala Ala Leu Glu Thr Thr Gly Glu Gin 2980 2985 2990 Ala Gly Thr Gly Lys Pro Val Glu Leu Thr Gin Arg Leu Ala Gly Leu 2995 3000 3005 Ser Arg Lys Glu Arg Asp Asp Ala Val Leu Asp Leu Val Arg Ala Glu 3010 3015 3020 Thr Ala Ala Val Leu Gly Arg Asp Asp Ala Thr Ala Leu Ala Pro Ser 3025 3030 3035 3040 Arg Pro Phe Gin Glu Leu Gly Phe Asp Ser Leu Met Ala Val Glu Leu 3045 3050 3055 Arg Asn Arg Leu Asn Thr Ala Thr Gly lie Gin Leu Pro Ala Ser Thr 3060 3065 3070 lie Phe Asp Tyr Pro Asn Ala Glu Ser Leu Ser Arg His Leu Cys Ala 3075 3080 3085 Glu Leu Phe Pro Thr Glu Thr Thr Val Asp Ser Ala Leu Ala Glu Leu 3090 3095 3100 Asp Arg lie Glu Gin Gin Leu Ser Met Leu Thr Gly Glu Ala Arg Ala 3105 3110 3115 3120 Arg Asp Arg lie Ala Thr Arg Leu Arg Ala Leu His Glu Lys Trp Asn 3125 3130 3135 Ser Ala Ala Glu Val Pro Thr Gly Ala Asp Val Leu Ser Thr Leu Asp
25 1237058 六 、申請專利範圍 3140 3145 3150 Ser Ala Thr His Asp Glu lie Phe Glu Phe lie Asp Asn Glu Leu Asp 3155 3160 3165 Leu Ser 3170 序列辨識號碼:5 Val Glu lie Thr Met Ala Asn Glu Glu Lys Leu Phe Gly Tyr Leu Lys 1 5 10 15 Lys Val Thr Ala Asp Leu His Gin Thr Arg Gin Arg Leu Leu Ala Ala 20 25 30 Glu Ser Arg Ser Gin Glu Pro lie Ala lie Val Ser Ala Ser Cys Arg 35 40 45 Leu Pro Gly Gly Val Asp Ser Pro Glu Ala Leu Trp Gin Leu Val Arg 50 55 60 Thr Gly Thr Asp Ala lie Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp 65 70 75 80 Leu Gly Arg Leu Tyr Asp Pro Asp Pro Asn His Gin Gly Thr Ser Tyr 85 90 95 Thr Arg Ala Gly Gly Phe Leu Ala Gly Ala Gly Asp Phe Asp Pro Ala 100 105 110 Met Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin 115 120 125 Arg Leu Leu Leu Glu Leu Ser Trp Glu Ala Leu Glu Arg Ala Gly lie 130 135 140 Asp Pro Thr Ser Leu Arg Gly Ser Lys Thr Gly Val Phe Gly Gly Val 145 150 155 160 Thr Pro Gin Glu Tyr Gly Pro Ser Leu Gin Glu Met Ser Arg Asn Ala 165 17 0 175 Gly Gly Phe Gly Leu Thr Gly Arg Met Val Ser Val Ala Ser Gly Arg 180 185 190 Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr 195 200 205 Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Cys Gin Ser Leu 210 215 220 Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met 225 230 235 240 Ala Thr Pro Ala Thr Phe Val Glu Phe Ser Arg Gin Arg Gly Leu Ala 245 250 255 Pro Asp Gly Arg Cys Lys Ser Phe Ala Ala Ala Ala Asp Gly Thr Gly 260 265 2 70 Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp Ala
26 1237058 六 •申請專利範圍 275 280 285 Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg Gly Ser Ala Val 290 295 300 Asn Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser 305 310 315 320 Gin Gin Arg Val He Thr Gin Ala Leu Ala Ser Ala Gly Leu Ser Val 325 330 335 Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly 340 345 350 Asp Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr Gly Gin Gly Arg 355 360 365 Glu Lys Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly 370 375 380 His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val Leu 385 390 395 400 Ala Met Arg His Gly Gin Leu Pro Ala Thr Leu His Val Asp Glu Pro 405 410 415 Thr Ser Ala Val Asp Trp Ser Ala Gly Ser Val Arg Leu Leu Thr Glu 420 425 430 Asn Thr Pro Trp Pro Asp Ser Gly Arg Pro Cys Arg Val Gly Val Ser 435 440 445 Ser Phe Gly lie Ser Gly Thr Asn Ala His Val He Leu Glu Gin Ser 450 455 460 Pro Val Glu Gin Gly Glu Pro Ala Gly Pro Val Glu Gly Glu Arg Glu 465 470 475 480 Pro Asp Val Ala Val Pro Val Val Pro Trp Val Leu Ser Gly Lys Thr 485 490 495 Pro Glu Ala Ala Arg Ala Gin Ala Glu Arg Val His Ser His lie Glu 500 505 510 Asp Arg Pro Gly Leu Ser Pro Val Asp Val Ala Tyr Ser Leu Gly Met 515 520 525 Thr Arg Ala Ala Leu Asp Glu Arg Ala Val Val Leu Gly Ser Asp Arg 530 535 540 Ala Ala Leu Leu Thr Gly Leu Arg Ala Phe Ala Asp Gly Cys Asp Ala 545 550 555 560 Pro Glu Val Val Ser Gly Ser Val Gly Leu Gly Gly Arg Val Gly Phe 565 570 575 Val Phe Ser Gly Gin Gly Gly Gin Trp Pro Gly Met Gly Arg Gly Leu 580 585 590 Tyr Ser Val Phe Pro Val Phe Ala Asp Ala Phe Asp Glu Ala Cys Ala
27 1237058 六 、申請專利範圍 595 600 605 Glu Leu Asp Ala His Leu Gly Gin Glu Leu Arg Val Arg Asp Val Val 610 615 620 Phe Gly Ser Gin Ala Trp Leu Leu Asp Arg Thr Val Trp Ala Gin Ser 625 630 635 640 Gly Leu Phe Ala Leu Gin lie Gly Leu Leu Arg Leu Leu Gly Ser Trp 645 650 655 Gly Val Arg Pro Asp Val Val Leu Gly His Ser Val Gly Glu Leu Ala 660 665 670 Ala Val His Ala Ala Gly Val Leu Ser Leu Ser Glu Ala Ala Arg Leu 6 75 680 685 Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Ala 690 695 700 Met Leu Ala Val Ala Thr Gly Glu Phe Gin Val Asp Pro Leu Leu Asp 7 05 710 715 720 Gly Val Arg Asp Arg lie Gly lie Ala Ala Val Asn Gly Pro Glu Ser 725 730 735 Val Val Leu Ser Gly Asp Arg Glu Leu Leu Thr Glu lie Ala Asp Arg 740 745 750 Leu His Asp Gin Gly Cys Arg Thr Arg Trp Leu Arg Val Ser His Ala 755 760 765 Phe His Ser Pro His Met Glu Pro Met Leu Glu Glu Phe Ala Gin lie 770 775 780 Ser Arg Gly Arg Glu Tyr His Ala Pro Glu Leu Pro lie lie Ser Thr 785 790 7 95 800 Leu lie Gly Glu Leu Asp Gly Gly Arg Val Met Gly Thr Pro Glu Tyr 805 810 815 Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe Ala Glu Gly Val Gin 820 825 830 Ala Leu Val Gly Gin Gly Val Gly Thr lie Val Glu Leu Gly Pro Asp 835 840 845 Gly Ala Leu Ser Thr Leu Val Glu Glu Cys Val Ala Glu Ser Gly Arg 850 855 860 Val Ala Gly lie Pro Leu Met Arg Lys Asp Arg Asp Glu Ala Arg Thr 865 870 875 880 Val Leu Ala Ala Leu Ala Gin lie His Thr Arg Gly Gly Glu Val Asp 885 890 895 Trp Arg Ser Phe Phe Ala Gly Thr Gly Ala Lys Gin Val Asp Leu Pro 900 905 910 Thr Tyr Ala Phe Gin Arg Gin Arg Tyr Trp Leu Ala Ser Thr Gly Arg
28 1237058 六 、申請專利範圍 915 920 925 Ala Gly Asp Val Thr Ala Ala Gly Leu Ala Glu Ala Asp His Pro Leu 930 935 940 Leu Gly Ala Val Val Ala Leu Ala Asp Gly Glu Gly Val Val Leu Thr 945 950 955 960 Gly Arg Leu Thr Ala Gly Ser His Pro Trp Leu Ser Asp His Arg Val 965 970 975 Leu Gly Glu lie Val Val Pro Gly Thr Ala lie Val Glu Leu Val Trp 980 985 990 His Val Gly Glu Arg Leu Gly Cys Gly Arg Val Glu Glu Leu Ala Leu 995 1000 1005 Glu Ala Pro Leu lie Leu Pro Asp His Gly Ala Val Gin Val Gin Val 1010 1015 1020 Leu Val Gly Pro Pro Gly Glu Ser Gly Ala Arg Ser Val Ala Leu Tyr 1025 1030 1035 1040 Ser Cys Pro Gly Glu Ala lie Glu Pro Glu Trp Lys Lys His Ala Thr 1045 1050 1055 Gly Val Leu Leu Pro Pro Val Ala Ala Glu Asn His Glu Leu Thr Ala 1060 1065 1070 Trp Pro Pro Glu Asn Ala Thr Glu lie Asp Ala Asp Gly Val Tyr Ala 1075 1080 1085 Phe Leu Glu Gly His Gly Phe Ala Tyr Gly Pro Ala Phe Arg Cys Leu 1090 1095 1100 Arg Gly Ala Trp Arg Arg Gly Gly Glu Val Phe Ala Glu Val Ala Leu 1105 1110 1115 1120 Pro Asp Asp Met Gin Ala Gly Val Asp Arg Phe Gly Val His Pro Ala 1125 1130 1135 Leu Leu Asp Ala Val Leu His Ala Ala Ala Ala Glu Thr Ser Val Val 1140 1145 1150 Gin Ser Glu Ala Arg Val Pro Phe Ser Trp Arg Gly Val Glu Leu Arg 1155 1160 1165 Ala Thr Glu Ser Ala Val Val Arg Ala Arg Leu Ser Leu Thr Ser Asp 117 0 1175 1180 Asp Glu Leu Ser Leu Val Ala Val Asp Pro Ala Gly Arg Phe Val Ala 1185 1190 1195 1200 Thr Val Asp Ser Leu Val Thr Arg Pro lie Ser Arg Gin Gin Val Arg 1205 1210 1215 Ser Gly Ala lie Gly Asp Cys Leu Phe Glu Val Glu Trp His Arg Lys 1220 1225 1230 Ala Leu Leu Gly Thr Thr Ala Gly Asp Asp Leu Ala lie Val Gly Asp
29 1237058 -Λ-/ \ 、申請專利範圍 1235 1240 1245 Gly Pro Ser Trp Pro Glu Ser Val Arg Ala Thr Ala Arg Phe Ala Thr 1250 1255 1260 Leu Asp Glu Phe Arg Ala Ala Val Asp Ser Asp Val Pro Ala Pro Gly 1265 1270 1275 1280 Ser Val Leu Val Ala Ala Met Ser Ala Glu Glu Val Glu Gly Gly Ser 1285 1290 1295 Leu Pro Ser Arg Ala Gin Glu Ser Thr Ser Asp Leu Leu Ala Leu Val 1300 1305 1310 Gin Ser Trp Leu Ala Asp Glu Arg Phe Ala Glu Ser Gin Leu Val Val 1315 1320 1325 Val Thr Arg Ala Ala Val Ser Ala Asp Ser Asp Ser Asp Val Ala Asp 1330 1335 1340 Leu Val Gly Ala Ser Ser Trp Gly Leu Leu Ser Ser Ala Gin Ser Glu 1345 1350 1355 1360 Asn Pro Gly Arg Phe Val Leu Val Asp Val Asp Gly Thr Pro Glu Ser 1365 1370 1375 Trp Gin Ala Leu Pro Ala Ala Val Arg Ala Gly Glu Pro Gin Leu Ala 1380 1385 1390 Leu Arg Arg Gly Val Ala Leu Val Pro Arg Leu Ala Arg Leu Thr Val 1395 1400 1405 Arg Glu Glu Gly Ser Ser Pro Gin Leu Asp Thr Asp Gly Thr Val Leu 1410 1415 1420 lie Thr Gly Gly Thr Gly Ala Leu Gly Gly Val Val Ala Arg His Leu 1425 1430 1435 1440 Val Glu Glu His Gly lie Arg Arg Leu Val Leu Ala Gly Arg Arg Gly 1445 1450 1455 Trp Asn Ala Pro Gly Val His Glu Leu Val Asp Glu Leu Ala Arg Ala 1460 1465 1470 Gly Ala Val Val Glu Val Val Ala Cys Asp Val Ala Asp Arg Thr Asp 1475 1480 1485 Leu Glu His Val Leu Ala Ala lie Pro Val Asp Trp Pro Leu Arg Gly 1490 1495 1500 lie Val His Thr Ala Gly Val Leu Ala Asp Gly Val lie Gly Ser Leu 1505 1510 1515 1520 Ser Ala Ala Asp Val Gly Thr Val Phe Ala Pro Lys Val Thr Gly Ala 1525 1530 1535 Trp His Leu His Glu Leu Thr Arg Asp Leu Asp Leu Ser Phe Phe Val 1540 1545 1550 Leu Phe Ser Ser Phe Ser Gly He Ala Gly Ala Ala Gly Gin Ala Asn
30 1237058 六 、申請專利範圍 1555 1560 1565 Tyr Ala Ala Ala Asn Thr Phe Leu Asp Ala Leu Ala Arg Tyr Arg Arg 15 7 0 1575 1580 Ala Arg Gly Leu Pro Gly Leu Ser Leu Ala Trp Gly Leu Trp Ala Gin 1585 1590 1595 1600 Pro Ser Gly Met Thr Ser Gly Leu Asp Ala Ala Ser Val Glu Arg Leu 1605 1610 1615 Ala Arg Thr Gly lie Ala Glu Leu Ser Thr Glu Asp Gly Leu Arg Leu 1620 1625 1630 Phe Asp Ala Ala Phe Ala Lys Asp Arg Ala Cys Val Val Ala Ala Arg 1635 1640 1645 Leu Asp Arg Ala Leu Leu Val Gly Asn Gly Arg Ser His Ala lie Pro 1650 1655 1660 Ala Leu Leu Ser Ala Leu Val Pro Val Arg Gly Gly Val Ala Arg Lys 1665 16 7 0 1675 1680 Thr Ala Asn Ser Gin Ala Ala Asp Glu Asp Ala Leu Leu Gly Leu Val 1685 1690 1695 Arg Glu His Val Ser Ala Val Leu Gly Tyr Ser Gly Ala Val Glu Val 17 00 1705 1710 Gly Gly Asp Arg Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Ser Gly 1715 1720 1725 Val Glu Leu Arg Asn Arg Leu Ala Gly Val Leu Gly Val Arg Leu Pro 1730 1735 1740 Ala Thr Ala Val Phe Asp Tyr Pro Thr Pro Arg Ala Leu Ala Arg Phe 1745 1750 1755 1760 Leu His Gin Glu Leu Ala Gly Glu Val Ala Ser Thr Ser Thr Pro Val 1765 177 0 1775 Thr Arg Ala Ala Ser Ala Glu Glu Asp Leu Val Ala lie Val Gly Met 1780 1785 1790 Gly Cys Arg Phe Pro Gly Gly Val Ser Ser Pro Glu Glu Leu Trp Arg 1795 1800 1805 Leu Val Ala Gly Gly Val Asp Ala Val Ala Gly Phe Pro Asp Asp Arg 1810 1815 1820 Gly Trp Asp Leu Ala Ala Leu Tyr Asp Pro Asp Pro Asp Arg Leu Gly 1825 1830 1835 1840 Thr Ser Tyr Val Cys Glu Gly Gly Phe Leu Arg Asp Ala Ala Glu Phe 1845 1850 1855 Asp Ala Asp Met Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp 1860 1865 187 0 Pro Gin Gin Arg Leu Leu Leu Glu Val Ala Trp Glu Thr Leu Glu Arg
31 1237058 六 、申請專利範圍 1875 1880 1885 Ala Gly lie Asp Pro Phe Ser Leu His Gly Ser Arg Thr Gly Val Phe 1890 1895 1900 Ala Gly Leu Met Tyr His Asp Tyr Gly Ala Arg Phe lie Thr Arg Ala 1905 1910 1915 1920 Pro Glu Gly Phe Glu Gly His Leu Gly Thr Gly Asn Ala Gly Ser Val 1925 1930 1935 Leu Ser Gly Arg Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val 1940 1945 1950 Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 1955 1960 1965 Gly Gin Ala Leu Arg Ala Gly Glu Cys Glu Phe Ala Leu Ala Gly Gly 1970 1975 1980 Val Thr Val Met Ser Thr Pro Thr Thr Phe Val Glu Phe Ser Arg Gin 1985 1990 1995 2000 Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ala Ala Ala Ala 2005 2010 2015 Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg 2020 2025 2030 Leu Ser Asp Ala Arg Arg Asn Gly His Glu Val Leu Ala Val Val Arg 2035 2040 2045 Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 2050 2055 2060 Asn Gly Pro Ser Gin Gin Arg Val lie Thr Gin Ala Leu Thr Ser Ala 2065 2070 2075 2080 Gly Leu Ser Val Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly 2085 2090 2095 Thr Arg Leu Gly Asp Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr 2100 2105 2110 Gly Arg Asp Arg Asp Pro Gly Arg Pro Leu Trp Leu Gly Ser Val Lys 2115 2120 2125 Ser Asn lie Gly His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie 2130 2135 2140 Lys Met Val Met Ala Met Arg Gin Gly Glu Leu Pro Arg Thr Leu His 2145 2150 2155 2160 Val Asp Glu Pro Ser Ala Gin Val Asp Trp Ser Ala Gly Thr Val Gin 2165 2170 2175 Leu Leu Thr Glu Asn Thr Pro Trp Pro Asp Ser Gly Arg Leu Arg Arg 2180 2185 2190 Ala Gly Val Ser Ser Phe Gly lie Ser Gly Thr Asn Ala His Leu lie 32 1237058 六 、申請專利範圍 2195 2200 2205 Leu Glu Gin Pro Pro Arg Glu Ser Gin Arg Ser Thr Glu Pro Asp Ser 2210 2215 2220 Gly Ser Val Arg Asp Phe Pro Val Val Pro Trp Met Val Ser Gly Lys 2225 2230 2235 2240 Thr Pro Glu Ala Leu Ser Ala Gin Ala Asp Ala Leu Met Ser Tyr Leu 2245 2250 2255 Ser Asn Arg Val Asp Ala Ser Pro Arg Asp lie Gly Tyr Ser Leu Ala 2260 2265 2270 Val Thr Arg Pro Ala Leu Asp His Arg Ala Val Val Leu Gly Ala Asp 2275 2280 2285 Arg Ala Ala Leu Leu Pro Gly Leu Lys Ala Leu Ala Val Ser Asn Asp 2290 2295 2300 Ala Ala Glu Val lie Thr Gly Thr Arg Ala Ala Gly Pro Val Gly Phe 2305 2310 2315 2320 Val Phe Ser Gly Gin Gly Gly Gin Trp Pro Gly Met Gly Ser Gly Leu 2325 2330 2335 His Ser Ala Phe Pro Val Phe Ala Asp Ala Phe Asp Glu Ala Cys Cys 2340 2345 2350 Glu Leu Asp Ala His Leu Gly Gin Met Ala Arg Leu Arg Asp Val Leu 2355 2360 2365 Ser Gly Ser Asp Thr Gin Leu Leu Asp Gin Thr Leu Trp Ala Gin Pro 2370 2375 2380 Gly Leu Phe Ala Leu Gin Val Gly Leu Trp Glu Leu Leu Gly Ser Trp 2385 2390 2395 2400 Gly Val Arg Pro Ala Val Val Leu Gly His Ser Val Gly Glu Leu Ala 2405 2410 2415 Ala Ala Phe Ala Ala Gly Val Leu Ser Leu Arg Asp Ala Ala Arg Leu 2420 2425 2430 Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu Pro Thr Gly Gly Ala 2435 2440 2445 Met Leu Ala Ala Ala Ala Gly Glu Glu Gin Leu Arg Pro Leu Leu Ala 2450 2455 2460 Asp Cys Gly Asp Arg Val Gly lie Ala Ala Val Asn Ala Pro Gly Ser 2465 2470 2475 2480 Val Val Leu Ser Gly Asp Arg Asp Val Leu Asp Asp He Ala Gly Arg 2485 2490 2495 Leu Asp Gly Gin Gly lie Arg Ser Arg Trp Leu Arg Val Ser His Ala 2500 2505 2510 Phe His Ser His Arg Met Asp Pro Met Leu Ala Glu Phe Thr Glu lie
-33 - 1237058 六 、申請專利範圍 2515 2520 2525 Ala Arg Ser Val Asp Tyr Arg Ser Ser Gly Leu Pro lie Val Ser Thr 2530 2535 2540 Leu Thr Gly Glu Leu Asp Glu Val Gly Met Pro Ala Thr Pro Glu Tyr 2545 2550 2555 2560 Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Ala 2565 2570 2575 Ala Leu Ala Ala His Gly Val Ser Thr Val Val Glu Val Gly Pro Asp 2580 2585 2590 Gly Val Leu Ser Ala Leu Val Gin Glu Cys Ala Ala Gly Ser Asp Gin 2595 2600 2605 Gly Gly Arg Val Ala Ala Val Pro Leu Met Arg Ser Asn Arg Asp Glu 2610 2615 2620 Ala His Thr Val Thr Thr Ala Leu Ala Gin lie His Val Arg Gly Ala 2625 2630 2635 2640 Glu Val Asp Trp Arg Ser Phe Phe Ala Gly Thr Gly Ala Lys Gin Val 2645 2650 2655 Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin Arg Tyr Trp Leu Asp Ser 2660 2665 2670 Pro Ser Glu Pro Val Gly Gin Ser Ala Asp Pro Ala Arg Gin Ser Gly 2675 2680 2685 Phe Trp Glu Leu Val Glu Gin Glu Asp Val Ser Ala Leu Ser Ala Ala 2690 2695 2700 Leu His lie Thr Gly Asp His Asp Val Gin Ala Ser Leu Glu Ser Val 2705 2710 2715 2720 Val Pro Val Leu Ser Ser Trp His Arg Arg He Arg Asn Glu Ser Leu 2 725 2730 2735 Val His Gin Trp Arg Tyr Arg lie Ser Trp His Glu Arg Ala Asp Leu 2 740 2745 2750 Pro Asp Pro Ser Leu Ser Gly Thr Trp Leu Val Val Val Pro Glu Gly 2755 2760 2765 Trp Ser Ala Ser Arg Gin Val Leu Arg Phe Asn Glu Met Phe Glu Glu 2770 2775 2780 Arg Gly Cys Pro Ala Val Leu Phe Glu Leu Ala Gly His Asp Glu Glu 2785 2790 2795 2800 Ala Leu Ala Gin Arg Phe Arg Ser Leu Pro Val Ala Ser Gly Gly lie 2805 2810 2815 Ser Gly Val Leu Ser Leu Leu Ala Leu Asp Glu Ser Pro Ser Ser Pro 2820 2825 2830 Asn Ala Ala Leu Pro Asn Gly Ala Leu Asn Ser Leu Val Leu Leu Arg
34 1237058 六 、申請專利範圍 2835 2840 2845 Ala Leu Arg Ala Ala Asp Val Ser Ala Pro Leu Trp Leu Ala Thr Cys 2850 2855 2860 Gly Gly Val Ala Val Gly Asp Val Pro Val Asn Pro Gly Gin Ala Leu 2865 2870 2875 2880 Val Trp Gly Leu Gly Arg Val Val Gly Leu Glu His Pro Ala Trp Trp 2885 2890 2895 Gly Gly Leu Val Asp Val Pro Cys Leu Leu Asp Glu Asp Ala Arg Glu 2900 2905 2910 Arg Leu Ser Val Val Leu Ala Gly Leu Gly Glu Asp Glu lie Ala Val 2915 2920 2925 Arg Pro Gly Gly Val Phe Val Arg Arg Leu Glu Arg Ala Gly Ala Ala 2930 2935 2940 Ser Gly Ala Gly Ser Val Trp Arg Pro Arg Gly Thr Val Leu Val Thr 2945 2950 2955 2960 Gly Gly Thr Gly Gly Leu Gly Ala His Val Ala Arg Trp Leu Ala Gly 2965 2970 2975 Ala Gly Ala Glu His Val Val Leu Thr Ser Arg Arg Gly Ala Ala Ala 2980 2985 2990 Pro Gly Ala Gly Asp Leu Arg Ala Glu Leu Glu Ala Leu Gly Ala Arg 2995 3000 3005 Val Ser lie Thr Ala Cys Asp Val Ala Asp Arg Asp Ala Leu Ala Glu 3010 3015 3020 Val Leu Ala Thr lie Pro Asp Asp Cys Pro Leu Thr Ala Val Met His 3025 3030 3035 3040 Ala Ala Gly Val Val Glu Val Gly Asp Val Ala Ser Met Cys Leu Thr 3045 3050 3055 Asp Phe Val Gly Val Leu Ser Ala Lys Ala Gly Gly Ala Ala Asn Leu 3060 3065 3070 Asp Glu Leu Leu Ala Asp Val Glu Leu Asp Ala Phe Val Leu Phe Ser 3075 3080 3085 Ser Val Ser Gly Val Trp Gly Ala Gly Gly Gin Gly Ala Tyr Ala Ala 3090 3095 3100 Ala Asn Ala Tyr Leu Asp Ala Leu Ala Gin Gin Arg Arg Ala Arg Gly 3105 3110 3115 3120 Leu Val Gly Thr Ala Val Ala Trp Gly Pro Trp Ala Gly Asp Gly Met 3125 3130 3135 Ala Ala Gly Glu Gly Gly Ala Gin Leu Arg Arg Ala Gly Leu Val Pro 3140 3145 3150 Met Ala Ala Asp Arg Ala Leu Leu Ala Leu Gin Gly Ala Leu Asp Arg
35 1237058 六 、申請專利範圍 3155 3160 3165 Asp Glu Thr Ser Leu Val Val Ala Asp Met Ala Trp Glu Arg Phe Ala 3170 3175 3180 Pro Val Phe Ala Met Ser Arg Arg Arg Pro Leu Leu Asp Glu Leu Pro 3185 3190 3195 3200 Glu Ala Gin Gin Ala Leu Ala Asp Ala Glu Asn Thr Thr Asp Ala Ala 3205 3210 3215 Asp Ser Ala Val Pro Leu Pro Arg Leu Ala Gly Met Ala Ala Ala Glu 3220 3225 3230 Arg Arg Arg Ala Met Leu Asp Leu Val Leu Ala Glu Ala Ser lie Val 3235 3240 3245 Leu Gly His Asn Gly Ser Asp Pro Val Gly Pro Asp Arg Ala Phe Gin 3250 3255 3260 Glu Leu Gly Phe Asp Ser Leu Met Ala Val Glu Leu Arg Asn Arg Leu 3265 3270 3275 3280 Gly Glu Ala Thr Gly Leu Ser Leu Pro Ala Thr Leu lie Phe Asp Tyr 3285 3290 3295 Pro Ser Pro Ser Ala Leu Ala Glu Gin Leu Val Gly Glu Leu Val Gly 3300 3305 3310 Ala Gin Pro Ala Thr Thr Val Val Ala Gly Ala Asp Pro Val Asp Asp 3315 3320 3325 Pro Val Val Val Val Ala Met Gly Cys Arg Tyr Pro Gly Asp Val Cys 3330 3335 3340 Ser Pro Glu Glu Leu Trp Gin Leu Val Ser Ala Gly Arg Asp Ala Val 3345 3350 3355 3360 Ser Thr Phe Pro Val Asp Arg Gly Trp Asp Cys Asn Thr Leu Phe Asp 3365 3370 3375 Pro Asp Pro Asp Arg Ala Gly Ser Thr Tyr Val Arg Glu Gly Ala Phe 3380 3385 3390 Leu Thr Gly Ala Asp Arg Phe Asp Ala Gly Phe Phe Gly lie Ser Pro 3395 3400 3405 Arg Glu Ala Arg Ala Met Asp Pro Gin Gin Arg Leu Leu Leu Glu Val 3410 3415 3420 Ala Trp Glu Val Phe Glu Arg Ala Gly lie Ala Pro Leu Ser Leu Arg 3425 3430 3435 3440 Gly Ser Arg Thr Gly Val Phe Ala Gly Thr Asn Gly Gin Asp His Gly 3445 3450 3455 Ala Lys Val Ala Ala Ala Pro Glu Ala Ala Gly His Leu Leu Thr Gly 3460 3465 3470 Asn Ala Ala Ser Val Leu Ala Gly Arg Leu Ser Tyr Thr Phe Gly Leu
36 1237058 六 、申請專利範圍 34 75 3480 3485 Glu Gly Pro Ala Val Ala Val Asp Thr Ala Cys Ser Ser Ser Leu Val 3490 3495 3500 Ala Leu His Leu Ala Cys Gin Ser Leu Arg Ser Gly Glu Cys Asp Met 3505 3510 3515 3520 Ala Leu Ala Gly Gly Val Thr Val Met Ser Thr Pro Leu Ala Phe Leu 3525 3530 3535 Glu Phe Ser Arg Gin Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser 3540 3545 3550 Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Leu 3555 3560 3565 Val Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Arg Val 3570 3575 3580 Leu Ala Val Val Arg Gly Ser Ala Val Asn Gin Asp Gly Ala Ser Asn 3585 3590 3595 3600 Gly Leu Thr Ala Pro Asn Gly Pro Ser Gin Gin Arg Val lie Arg Gin 3605 3610 3615 Ala Leu Ala Asn Ala Gly Leu Ser Ala Ser Asp Val Asp Val Val Glu 3620 3625 3630 Ala His Gly Thr Gly Thr Gly Leu Gly Asp Pro lie Glu Ala Gin Ala 3635 3640 3645 Leu lie Ala Thr Tyr Gly Gin Glu Arg Asp Pro Glu Arg Ala Leu Trp 3650 3655 3660 Leu Gly Ser lie Lys Ser Asn lie Gly His Thr Gin Ala Ala Ala Gly 3665 3670 3675 3680 Val Ala Gly Val lie Lys Met Val Gin Ala Met Arg His Gly Glu Leu 3685 3690 3695 Pro Ala Thr Leu His Val Asp Lys Pro Thr Pro Gin Val Asp Trp Ser 3700 3705 3710 Ala Gly Ala Val Arg Leu Leu Thr Gly Asn Thr Pro Trp Pro Glu Ser 3715 3720 3725 Gly Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly lie Ser Gly Thr 3730 3735 3740 Asn Ala His Leu lie Leu Glu Gin Pro Pro Ser Glu Pro Ala Glu lie 3745 3750 3755 3760 Asp Gin Ser Asp Arg Arg Val Thr Ala His Pro Ala Val lie Pro Trp 3 765 3770 3775 Met Leu Ser Ala Arg Ser Leu Ala Ala Leu Gin Ala Gin Ala Ala Ala 3780 3785 3790 Leu Gin Ala Arg Leu Asp Arg Gly Pro Gly Ala Ser Pro Leu Asp Leu 3 7
1237058 / \ 、申請專利範圍 3795 3800 3805 Gly Tyr Ser Leu Ala Thr Thr Arg Ser Val Leu Asp Glu Arg Ala Val 3810 3815 3820 Val Trp Gly Ala Asp Arg Glu Ala Leu Leu Ser Arg Leu Ala Ala Leu 3825 3830 3835 3840 Ala Asp Gly Arg Thr Ala Pro Gly Val lie Thr Gly Ser Ala Asn Ser 3845 3850 3855 Gly Gly Arg lie Gly Phe Val Phe Ser Gly Gin Gly Ser Gin Trp Leu 3860 3865 3870 Gly Met Gly Lys Ala Leu Cys Ala Ala Phe Pro Ala Phe Ala Asp Ala 3875 3880 3885 Phe Glu Glu Ala Cys Asp Ala Leu Ser Ala His Leu Gly Ala Asp Val 3890 3895 3900 Arg Gly Val Leu Phe Gly Ala Asp Glu Gin Met Leu Asp Arg Thr Leu 3905 3910 3915 3920 Trp Ala Gin Ser Gly lie Phe Ala Val Gin Val Gly Leu Leu Gly Leu 3925 3930 3935 Leu Arg Ser Trp Gly Val Arg Pro Ala Ala Val Leu Gly His Ser Val 3940 3945 3950 Gly Glu Leu Ala Ala Ala His Ala Ala Gly Val Leu Ser Leu Pro Asp 3955 3960 3965 Ala Ala Arg Leu Val Ala Ala Arg Ala His Leu Met Gin Ala Leu Pro 3970 3975 3980 Thr Gly Gly Ala Met Leu Ala Val Ala Thr Ser Glu Ala Ala Val Gly 3985 3990 3995 4000 Pro Leu Leu Ser Gly Val Cys Asp Arg Val Ser lie Ala Ala lie Asn 4005 4010 4015 Gly Pro Glu Ser Val Val Leu Ser Gly Asp Arg Asp Val Leu Val Glu 4020 4025 4030 Leu Ala Gly Glu Phe Asp Ala Arg Gly Leu Arg Thr Lys Trp Leu Arg 4035 4040 4045 Val Ser His Ala Phe His Ser His Arg Met Glu Pro lie Leu Asp Glu 4050 4055 4060 Tyr Ala Glu Thr Ala Arg Cys Val Glu Phe Gly Glu Pro Val Val Pro 4065 4070 4075 4080 lie Val Ser Ala Ala Thr Gly Ala Leu Asp Thr Thr Gly Leu Met Cys 4085 4090 4095 Ala Ala Asp Tyr Trp Thr Arg Gin Val Arg Asp Pro Val Arg Phe Gly 4100 4105 4110 Asp Gly Val Arg Ala Leu Val Gly Gin Gly Val Asp Thr lie Val Glu
38 1237058 六 、申請專利範圍 4115 4120 4125 Phe Gly Pro Asp Gly Ala Leu Ser Ala Leu Val Glu Gin Cys Leu Ala 4130 4135 4140 Gly Ser Asp Gin Ala Gly Arg Val Ala Ala lie Pro Leu Met Arg Arg 4145 4150 4155 4160 Asp Arg Asp Glu Val Glu Thr Ala Val Ala Ala Leu Ala His Val His 4165 4170 4175 Val Arg Gly Gly Ala Val Asp Trp Ser Ala Cys Phe Ala Gly Thr Gly 4180 4185 4190 Ala Arg Thr Val Glu Leu Pro Thr Tyr Ala Phe Gin Arg Gin Arg Tyr 4195 4200 4205 Trp Leu Ala Gly Gin Ala Asp Gly Arg Gly Gly Asp Val Val Ala Asp 4210 4215 4220 Pro Val Asp Ala Arg Phe Trp Glu Leu Val Glu Arg Ala Asp Pro Glu 4225 4230 4235 4240 Pro Leu Val Asp Glu Leu Cys lie Asp Arg Asp Gin Pro Phe Arg Glu 4245 4250 4255 Val Leu Pro Val Leu Ala Ser Trp Arg Glu Lys Gin Arg Gin Glu Ala 4260 4265 4270 Leu Ala Asp Ser Trp Arg Tyr Gin Val Arg Trp Arg Ser Val Glu Val 4275 4280 4285 Pro Ser Ala Ala Ala Leu Arg Gly Val Trp Leu Val Val Leu Pro Ala 4290 4295 4300 Asp Val Pro Arg Asp Gin Pro Ala Val Val lie Asp Ala Leu lie Ala 4305 4310 4315 4320 Arg Gly Ala Glu Val Ala Val Leu Glu Leu Thr Glu Gin Asp Leu Gin 4325 4330 4335 Arg Ser Ala Leu Val Asp Lys Val Arg Ala Val lie Ala Asp Arg Thr 4340 4345 4350 Glu Val Thr Gly Val Leu Ser Leu Leu Ala Met Asp Gly Met Pro Cys 4355 4360 4365 Ala Ala His Pro His Leu Ser Arg Gly Val Ala Ala Thr Val lie Leu 4370 4375 4380 Thr Gin Val Leu Gly Asp Ala Gly Val Ser Ala Pro Leu Trp Leu Ala 4385 4390 4395 4400 Thr Thr Gly Gly Val Glu Ala Gly Thr Glu Asp Gly Pro Ala Asp Pro 4405 4410 4415 Asp His Gly Leu lie Trp Gly Leu Gly Arg Val Val Gly Leu Glu His 4420 4425 4430 Pro Gin Trp Trp Gly Gly Leu He Asp Leu Pro Glu Thr Leu Asp Glu
39 1237058 六 、申請專利範圍 4435 4440 4445 Thr Ser Arg Asn Gly Leu Val Ala Ala Leu Ala Gly Thr Ala Ala Glu 4450 4455 4460 Asp Gin Leu Ala Val Arg Ser Ser Gly Leu Phe Val Arg Arg Val Val 4465 4470 44 75 4480 Arg Ala Ala Arg Asn Pro Arg Ser Glu Thr Trp Arg Ser Arg Gly Thr 4485 4490 4495 Val Leu lie Thr Gly Gly Thr Gly Ala Leu Gly Ala Glu Val Ala Arg 4500 4505 4510 Trp Leu Ala Arg Arg Gly Ala Glu His Leu Val Leu lie Ser Arg Arg 4515 4520 4525 Gly Pro Glu Ala Pro Gly Ala Ala Asp Leu Gly Ala Glu Leu Thr Glu 4530 4535 4540 Leu Gly Val Lys Val Thr Val Leu Ala Cys Asp Val Thr Asp Arg Asp 4545 4550 4555 4560 Glu Leu Ala Ala Val Leu Ala Ala Val Pro Thr Glu Tyr Pro Leu Ser 4565 4570 4575 Ala Val Val His Thr Ala Gly Val Gly Thr Pro Ala Asn Leu Ala Glu 4580 4585 4590 Thr Thr Leu Ala Gin Phe Ala Asp Val Leu Ser Ala Lys Val Val Gly 4595 4600 4605 Ala Ala Asn Leu Asp Arg Leu Leu Gly Gly Gin Pro Leu Asp Ala Phe 4610 4615 4620 Val Leu Phe Ser Ser He Ser Gly Val Trp Gly Ala Gly Gly Gin Gly 4625 4630 4635 4640 Ala Tyr Ser Ala Ala Asn Ala Tyr Leu Asp Ala Leu Ala Glu Arg Arg 4645 4650 4655 Arg Ala Cys Gly Arg Pro Ala Thr Cys lie Ala Trp Gly Pro Trp Ala 4660 4665 4670 Gly Ala Gly Met Ala Val Gin Glu Gly Asn Glu Ala His Leu Arg Arg 4675 4680 4685 Arg Gly Leu Val Pro Met Glu Pro Gin Ser Ala Leu Phe Ala Leu Gin 4690 4695 4700 Gin Ala Leu Ser Gin Arg Glu Thr Ala lie Thr Val Ala Asp Val Asp 4705 4710 4715 4720 Trp Glu Arg Phe Ala Ala Ser Phe Thr Ala Ala Arg Pro Arg Pro Leu 4725 4730 4735 Leu Glu Glu lie Val Asp Leu Arg Pro Asp Thr Glu Thr Glu Glu Lys 4740 4 745 4750 His Gly Ala Gly Glu Leu Gly Gin Gin Leu Ala Ala Leu Pro Pro Ala
40 1237058 、申請專利範圍 4755 4760 4765 Glu Arg Gly His Leu Leu Leu Glu Val Val Leu Ala Glu Thr Ala Ser 4 7 70 4775 4780 Thr Leu Gly His Asp Ser Ala Glu Ala Val Gin Pro Asp Arg Thr Phe 4785 4790 4795 4800 Ala Glu Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg 4805 4810 4815 Leu Asn Ala Val Thr Gly Leu Arg Leu Pro Pro Thr Leu Val Phe Asp 4820 4825 4830 His Pro Thr Pro Leu Ala Leu Ser Glu Gin Leu Val Pro Ala Leu Val 4835 4840 4845 Ala Glu Pro Asp Asn Gly lie Glu Ser Leu Leu Ala Glu Leu Asp Arg 4850 4855 4860 Leu Asp Thr Thr Leu Ala Gin Gly Pro Ser lie Pro Leu Glu Asp Gin 4865 4870 4875 4880 Ala Lys Val Ala Glu Arg Leu His Ala Leu Leu Ala Lys Trp Asp Gly 4885 4890 4895 Ala Arg Asp Gly Thr Ala Arg Ala Thr Ser Pro Gin Ser Leu Thr Ala 4900 4905 4910 Ala Thr Asp Asp Glu lie Phe Asp Leu lie Asp Arg Lys Phe Arg Arg 4915 4920 4925 序列辨識號碼:7 Val Leu Pro Gly Gly Ala Pro Thr Ser Gin Gin Val Gly Gin Met Tyr 1 5 10 15 Asp Leu Val Thr Pro Leu Leu Asn Ser Val Ala Gly Gly Pro Cys Ala 20 25 30 He His His Gly Tyr Trp Glu Asn Asp Gly Arg Ala Ser Trp Gin Gin 35 40 45 Ala Ala Asp Arg Leu Thr Asp Leu Val Ala Glu Arg Thr Val Leu Asp 50 55 60 Gly Gly Val Arg Leu Leu Asp Val Gly Cys Gly Thr Gly Gin Pro Ala 65 70 75 80 Leu Arg Val Ala Arg Asp Asn Ala lie Gin lie Thr Gly lie Thr Val 85 90 95 Ser Gin Val Gin Val Ala lie Ala Ala Asp Cys Ala Arg Glu Arg Gly 100 105 110 Leu Ser His Arg Val Asp Phe Ser Cys Val Asp Ala Met Ser Leu Pro 115 120 125 Tyr Pro Asp Asn Ala Phe Asp Ala Ala Trp Ala Met Gin Ser Leu Leu 130 135 140 Glu Met Ser Glu Pro Asp Arg Ala lie Arg Glu He Leu Arg Val Leu
41 1237058 六 、申請專利範圍 145 150 155 160 Lys Pro Gly Gly lie Leu Gly Val Thr Glu Val Val Lys Arg Glu Ala 165 170 175 Gly Gly Gly Met Pro Val Ser Gly Asp Arg Trp Pro Thr Gly Leu Arg 180 185 190 lie Cys Leu Ala Glu Gin Leu Leu Glu Ser Leu Arg Ala Ala Gly Phe 195 200 205 Glu lie Leu Asp Trp Glu Asp Val Ser Ser Arg Thr Arg Tyr Phe Met 210 215 220 Pro Gin Phe Ala Glu Glu Leu Ala Ala His Gin His Gly lie Ala Asp 225 230 235 240 Arg Tyr Gly Pro Ala Val Ala Gly Trp Ala Ala Ala Val Cys Asp Tyr 245 250 255 Glu Lys Tyr Ala His Asp Met Gly Tyr Ala lie Leu Thr Ala Arg Lys 260 265 270 Pro Val Gly 2 75 序列辨識號碼:8 Met Arg Val Leu Val Val Pro Leu Pro Tyr Pro Thr His Leu Met Ala 1 5 10 15 Met Val Pro Leu Cys Trp Ala Leu Gin Ala Ser Gly His Glu Val Leu 20 25 30 lie Ala Ala Pro Pro Glu Leu Gin Ala Thr Ala His Gly Ala Gly Leu 35 40 45 Thr Thr Ala Gly lie Arg Gly Asn Asp Arg Thr Gly Asp Thr Gly Gly 50 55 60 Thr Thr Gin Leu Arg Phe Pro Asn Pro Ala Phe Gly Gin Arg Asp Thr 65 7 0 75 80 Glu Ala Gly Arg Gin Leu Trp Glu Gin Thr Ala Ser Asn Val Ala Gin 85 90 95 Ser Ser Leu Asp Gin Leu Pro Glu Tyr Leu Arg Leu Ala Glu Ala Trp 100 105 110 Arg Pro Ser Val Leu Leu Val Asp Val Cys Ala Leu lie Gly Arg Val 115 120 125 Leu Gly Gly Leu Leu Asp Leu Pro Val Val Leu His Arg Trp Gly Val 130 135 140 Asp Pro Thr Ala Gly Pro Phe Ser Asp Arg Ala His Glu Leu Leu Asp 145 150 155 160 Pro Val Cys Arg His His Gly Leu Thr Gly Leu Pro Thr Pro Glu Leu 165 170 175 lie Leu Asp Pro Cys Pro Pro Ser Leu Gin Ala Ser Asp Ala Pro Gin
1237058 六 、申請專利範圍 180 185 190 Gly Ala Pro Val Gin Tyr Val Pro Tyr Asn Gly Ser Gly Ala Phe Pro 195 200 205 Ala Trp Gly Ala Ala Arg Thr Ser Ala Arg Arg Val Cys lie Cys Met 210 215 220 Gly Arg Met Val Leu Asn Ala Thr Gly Pro Ala Pro Leu Leu Arg Ala 225 230 235 240 Val Ala Ala Ala Thr Glu Leu Pro Gly Val Glu Ala Val lie Ala Val 245 250 255 Pro Pro Glu His Arg Ala Leu Leu Thr Asp Leu Pro Asp Asn Ala Arg 260 265 270 lie Ala Glu Ser Val Pro Leu Asn Leu Phe Leu Arg Thr Cys Glu Leu 275 280 285 Val lie Cys Ala Gly Gly Ser Gly Thr Ala Phe Thr Ala Thr Arg Leu 290 295 300 Gly lie Pro Gin Leu Val Leu Pro Gin Tyr Phe Asp Gin Phe Asp Tyr 305 310 315 320 Ala Arg Asn Leu Ala Ala Ala Gly Ala Gly lie Cys Leu Pro Asp Glu 325 330 335 Gin Ala Gin Ser Asp His Glu Gin Phe Thr Asp Ser lie Ala Thr Val 340 345 350 Leu Gly Asp Thr Gly Phe Ala Ser Ala Ala lie Lys Leu Ser Asp Glu 355 360 365 lie Thr Ala Met Pro His Pro Ala Ala Leu Val Arg Thr Leu Glu Asn 370 3 75 380 Thr Ala Ala lie Arg Ala 385 390 序列辨識號碼:9 Met Pro Ser Gin Asn Ala Leu Tyr Leu Asp Leu Leu Lys Lys Val Leu 1 5 10 15 Thr Asn Thr lie Tyr Ser Asp Arg Pro His Pro Asn Ala Trp Gin Asp 20 25 30 Asn Thr Asp Tyr Arg Gin Ala Ala Arg Ala Lys Gly Thr Asp Trp Pro 35 40 45 Thr Val Ala His Thr Met lie Gly Leu Glu Arg Leu Asp Asn Leu Gin 50 55 60 His Cys Val Glu Ala Val Leu Ala Asp Gly Val Pro Gly Asp Phe Ala 65 70 75 80 Glu Thr Gly Val Trp Arg Gly Gly Ala Cys lie Phe Met Arg Ala Val 85 90 95 Leu Gin Ala Phe Gly Asp Thr Gly Arg Thr Val Trp Val Val Asp Ser
43 1237058 六 、申請專利範圍 100 105 110 Phe Gin Gly Met Pro Glu Ser Ser Ala Gin Asp His Gin Ala Asp Gin 115 120 125 Ala Met Ala Leu His Glu Tyr Asn Asp Val Leu Gly Val Ser Leu Glu 130 135 140 Thr Val Arg Gin Asn Phe Ala Arg Tyr Gly Leu Leu Asp Glu Gin Val 145 150 155 160 Arg Phe Leu Pro Gly Trp Phe Arg Asp Thr Leu Pro Thr Ala Pro lie 165 170 175 Gin Glu Leu Ala Val Leu Arg Leu Asp Gly Asp Leu Tyr Glu Ser Thr 180 185 190 Met Asp Ser Leu Arg Asn Leu Tyr Pro Lys Leu Ser Pro Gly Gly Phe 195 200 205 Val lie lie Asp Asp Tyr Phe Leu Pro Ser Cys Gin Asp Ala Val Lys 210 215 220 Gly Phe Arg Ala Glu Leu Gly lie Thr Glu Pro lie His Asp lie Asp 225 230 235 240 Gly Thr Gly Ala Tyr Trp Arg Arg Ser Trp 245 250 序列辨識號碼:10 Met Ser Glu lie Ala Val Ala Pro Trp Ser Val Val Glu Arg Leu Leu 1 5 10 15 Leu Ala Ala Gly Ala Gly Pro Ala Lys Leu Gin Glu Ala Val Gin Val 20 25 30 Ala Gly Leu Asp Ala Val Ala Asp Ala lie Val Asp Glu Leu Val Val 35 40 45 Arg Cys Asp Pro Leu Ser Leu Asp Glu Ser Val Arg lie Gly Leu Glu 50 55 60 lie Thr Ser Gly Ala Gin Leu Val Arg Arg Thr Val Glu Leu Asp His 65 7 0 75 80 Ala Gly Leu Arg Leu Ala Ala Val Ala Glu Ala Ala Ala Val Leu Arg 85 90 95 Phe Asp Ala Val Asp Leu Leu Glu Gly Leu Phe Gly Pro Val Asp Gly 100 105 110 Arg Arg His Asn Ser Arg Glu Val Arg Trp Ser Asp Ser Met Thr Gin 115 120 125 Phe Ser Pro Asp Gin Gly Leu Ala Gly Ala Gin Arg Leu Leu Ala Phe 130 135 140 Arg Asn Arg Val Ser Thr Ala Val His Ala Val Leu Ala Ala Ala Ala 145 150 155 160 Thr Arg Arg Ala Asp Leu Gly Ala Leu Ala Val Arg Tyr Gly Ser Asp
44 1237058 六 、申請專利範圍 165 170 175 Lys Trp Ala Asp Leu His Trp Tyr Thr Glu His Tyr Glu His His Phe 180 185 190 Ser Arg Phe Gin Asp Ala Pro Val Arg Val Leu Glu lie Gly lie Gly 195 200 205 Gly Tyr His Ala Pro Glu Leu Gly Gly Ala Ser Leu Arg Met Trp Gin 210 215 220 Arg Tyr Phe Arg Arg Gly Leu Val Tyr Gly Leu Asp lie Phe Glu Lys 225 230 235 240 Ala Gly Asn Glu Gly His Arg Val Arg Lys Leu Arg Gly Asp Gin Ser 245 250 255 Asp Ala Glu Phe Leu Glu Asp Met Val Ala Lys lie Gly Pro Phe Asp 260 265 270 lie Val lie Asp Asp Gly Ser His Val Asn Asp His Val Lys Lys Ser 275 280 285 Phe Gin Ser Leu Phe Pro His Val Arg Pro Gly Gly Leu Tyr Val lie 290 295 300 Glu Asp Leu Gin Thr Ala Tyr Trp Pro Gly Tyr Gly Gly Arg Asp Gly 305 310 315 320 Glu Pro Ala Ala Gin Arg Thr Ser lie Asp Met Leu Lys Glu Leu lie 325 330 335 Asp Gly Leu His Tyr Gin Glu Arg Glu Ser Arg Cys Gly Thr Glu Pro 340 345 350 Ser Tyr Thr Glu Arg Asn Val Ala Ala Leu His Phe Tyr His Asn Leu 355 360 365 Val Phe Val Glu Lys Gly Leu Asn Ala Glu Thr Ala Ala Pro Gly Phe 370 375 380 Val Pro Arg Gin Ala Leu Gly Val Glu Gly Gly 385 390 395 序列辨識號碼:11 Met lie Ser Ala Ala Gly Glu Gin Ser Gly Pro Val Arg Lys Gly Gly 1 5 10 15 Ala Val Pro Glu Phe His Asp Pro Ala Pro Met Asn Arg Arg Thr Pro 20 25 30 Gly Thr Glu He Thr Val Glu Pro Asp Asp Pro Arg Tyr Pro Asp Leu 35 40 45 Val Val Gly His Asn Pro Arg Phe Thr Gly Lys Pro Glu Arg lie His 50 55 60 He Ala Ser Ser Ala Glu Asp Val Val His Ala Val Ala Asp Ala Val 65 70 75 80 Arg Thr Gly Arg Arg Val Gly Val Arg Ser Gly Gly His Cys Phe Glu
45 1237058 -Λ- /、 、申請專利範圍 85 90 95 Asn Leu Val Ala Asp Pro Ala lie Arg Val Leu Val Asp Leu Ser Glu 100 105 110 Leu Asn Arg Val Tyr Tyr Asp Ser Thr Arg Gly Ala Phe Ala He Glu 115 120 125 Ala Gly Ala Ala Leu Gly Gin Val Tyr Arg Thr Leu Phe Lys Asn Trp 130 135 140 Gly Val Thr lie Pro Thr Gly Ala Cys Pro Gly Val Gly Ala Gly Gly 145 150 155 160 His lie Leu Gly Gly Gly Tyr Gly Pro Leu Ser Arg Arg Phe Gly Ser 165 170 175 Val Val Asp Tyr Leu Gin Gly Val Glu Val Val Val Val Asp Gin Ala 180 185 190 Gly Glu Val His lie Val Glu Ala Asp Arg Asn Ser Thr Gly Ala Gly 195 200 205 His Asp Leu Trp Trp Ala His Thr Gly Gly Gly Gly Gly Asn Phe Gly 210 215 220 He Val Thr Arg Phe Trp Leu Arg Thr Pro Asp Val Val Ser Thr Asp 225 230 235 240 Ala Ala Glu Leu Leu Pro Arg Pro Pro Ala Thr Val Leu Leu Arg Ser 245 250 255 Phe His Trp Pro Trp His Glu Leu Thr Glu Gin Ser Phe Ala Val Leu 260 265 270 Leu Gin Asn Phe Gly Asn Trp Tyr Glu Gin His Ser Ala Pro Glu Ser 275 280 285 Thr Gin Leu Gly Leu Phe Ser Thr Leu Val Cys Ala His Arg Gin Ala 290 295 300 Gly Tyr Val Thr Leu Asn Val His Leu Asp Gly Thr Asp Pro Asn Ala 305 310 315 320 Glu Arg Thr Leu Ala Glu His Leu Ser Ala lie Asn Ala Gin Val Gly 325 330 335 Val Thr Pro Ala Glu Gly Leu Arg Glu Thr Leu Pro Trp Leu Arg Ser 340 345 350 Thr Gin Val Ala Gly Ala lie Ala Glu Gly Gly Glu Pro Gly Met Gin 355 360 365 Arg Thr Lys Val Lys Ala Ala Tyr Leu Arg Thr Gly Leu Ser Glu Ala 370 375 380 Gin Leu Ala Thr Val Tyr Arg Arg Leu Thr Val Tyr Gly Tyr Asp Asn 385 390 395 400 Pro Ala Ala Ala Leu Leu Leu Leu Gly Tyr Gly Gly Met Ala Asn Ala
46 1237058 六 、申請專利範圍 405 410 415 Val Ala Pro Ser Ala Thr Ala Leu Ala Gin Arg Asp Ser Val Leu Lys 420 425 430 Ala Leu Phe Val Thr Asn Trp Ser Glu Pro Ala Glu Asp Glu Arg His 435 440 445 Leu Thr Trp lie Arg Gly Phe Tyr Arg Glu Met Tyr Ala Glu Thr Gly 450 455 460 Gly Val Pro Val Pro Gly Thr Arg Val Asp Gly Ser Tyr lie Asn Tyr 465 470 475 480 Pro Asp Thr Asp Leu Ala Asp Pro Leu Trp Asn Thr Ser Gly Val Ala 485 490 495 Trp His Asp Leu Tyr Tyr Lys Asp Asn Tyr Pro Arg Leu Gin Arg Ala 500 505 510 Lys Ala Arg Trp Asp Pro Gin Asn lie Phe Gin His Gly Leu Ser lie 515 520 525 Lys Pro Pro Ala Arg Leu Ser Pro Gly Gin Pro 530 535 序列辨識號碼:12 Met Ser Thr Thr His Glu lie Glu Thr Val Glu Arg lie lie Leu Ala 1 5 10 15 Ala Gly Ser Ser Ala Ala Ser Leu Ala Asp Leu Thr Thr Glu Leu Gly 20 25 30 Leu Ala Arg lie Ala Pro Val Leu lie Asp Glu lie Leu Phe Arg Ala 35 40 45 Glu Pro Ala Pro Asp lie Glu Arg Thr Glu Val Ala Val Gin lie Thr 50 55 60 His Arg Gly Glu Thr Val Asp Phe Val Leu Thr Leu Gin Ser Gly Glu 65 7 0 75 80 Leu lie Lys Ala Glu Gin Arg Pro Val Gly Asp Val Pro Leu Arg lie 85 90 95 Gly Tyr Glu Leu Thr Asp Leu lie Ala Glu Leu Phe Gly Pro Gly Ala 100 105 110 Pro Arg Ala Val Gly Ala Arg Ser Thr Asn Phe Leu Arg Thr Thr Thr 115 120 125 Ser Gly Ser lie Pro Gly Pro Ser Glu Leu Ser Asp Gly Phe Gin Ala 130 135 140 lie Ser Ala Val Val Ala Gly Cys Gly His Arg Arg Pro Asp Leu Asn 145 150 155 160 Leu Leu Ala Ser His Tyr Arg Thr Asp Lys Trp Gly Gly Leu His Trp 165 170 175 Phe Thr Pro Leu Tyr Glu Arg His Leu Gly Glu Phe Arg Asp Arg Pro
-47 - 1237058 六 、申請專利範圍 180 185 190 Val Arg lie Leu Glu lie Gly Val Gly Gly Tyr Asn Phe Asp Gly Gly 195 200 205 Gly Gly Glu Ser Leu Lys Met Trp Lys Arg Tyr Phe His Arg Gly Leu 210 215 220 Val Phe Gly Met Asp Val Phe Asp Lys Ser Phe Leu Asp Gin Gin Arg 225 230 235 240 Leu Cys Thr Val Arg Ala Asp Gin Ser Lys Pro Glu Glu Leu Ala Ala 245 250 255 Val Asp Asp Lys Tyr Gly Pro Phe Asp lie lie lie Asp Asp Gly Ser 260 265 270 His lie Asn Gly His Val Arg Thr Ser Leu Glu Thr Leu Phe Pro Arg 275 280 285 Leu Arg Ser Gly Gly Val Tyr Val lie Glu Asp Leu Trp Thr Thr Tyr 290 295 300 Ala Pro Gly Phe Gly Gly Gin Ala Gin Cys Pro Ala Ala Pro Gly Thr 305 310 315 320 Thr Val Ser Leu Leu Lys Asn Leu Leu Glu Gly Val Gin His Glu Glu 325 330 335 Gin Pro His Ala Gly Ser Tyr Glu Pro Ser Tyr Leu Glu Arg Asn Leu 340 345 350 Val Gly Leu His Thr Tyr His Asn lie Ala Phe Leu Glu Lys Gly Val 355 360 365 Asn Ala Glu Gly Gly Val Pro Ala Trp Val Pro Arg Ser Leu Asp Asp 370 375 380 lie Leu His Leu Ala Asp Val Asn Ser Ala Glu Asp Glu 385 390 395 序列辨識號碼:13 Val Glu Ser lie Phe Asp Ala Leu Ala His Gly Arg Pro Leu His His 1 5 10 15 Gly Tyr Trp Ala Gly Gly Tyr Arg Glu Asp Ala Gly Ala Thr Pro Trp 20 25 30 Ser Asp Ala Ala Asp Gin Leu Thr Asp Leu Phe lie Asp Lys Ala Ala 35 40 45 Leu Arg Pro Gly Ala His Leu Phe Asp Leu Gly Cys Gly Asn Gly Gin 50 55 60 Pro Val Val Arg Ala Ala Cys Ala Ser Gly Val Arg Val Thr Gly lie 65 70 75 80 Thr Val Asn Ala Gin His Leu Ala Ala Ala Thr Arg Leu Ala Asn Glu 85 90 95 Thr Gly Leu Ala Gly Ser Leu Glu Phe Asp Leu Val Asp Gly Ala Gin
48 1237058 -Λ- /、 、申請專利範圍 100 105 110 Leu Pro Tyr Pro Asp Gly Phe Phe Gin Ala Ala Trp Ala Met Gin Ser 115 120 125 Val Val Gin lie Val Asp Gin Ala Ala Ala lie Arg Glu Val His Arg 130 135 140 lie Leu Glu Pro Gly Gly Arg Phe Val Leu Gly Asp lie lie Thr Arg 145 150 155 160 Val Arg Leu Pro Glu Glu Tyr Ala Ala Val Trp Thr Gly Thr Thr Ala 165 170 175 His Thr Leu Asn Ser Phe Thr Ala Leu Val Ser Glu Ala Gly Phe Glu 180 185 190 lie Leu Glu Val Thr Asp Leu Thr Ala Gin Thr Arg Cys Met Val Ser 195 200 205 Trp Tyr Val Asp Glu Leu Leu Arg Lys Leu Asp Glu Leu Ala Gly Val 210 215 220 Glu Pro Ala Ala Val Gly Thr Tyr Gin Gin Arg Tyr Leu Gly Asp lie 225 230 235 240 Ala Ala Lys His Gly Pro Gly Pro Ala Gin Leu lie Ala Ala Val Ala 245 250 255 Glu Tyr Arg Lys His Pro Asp Tyr Ala Arg Asn Glu Glu Ser Met Gly 260 265 270 Phe Met Leu Leu Gin Ala Arg Lys Lys Gin Ser 2 75 280 序列辨識號碼:14 Met Pro Asn Ala Val Ser Gly Thr Val Leu Val Pro Asn lie Pro Trp 1 5 10 15 Pro Arg Glu Asp Arg Pro lie lie Thr Phe Ala Val Gly Thr His Gly 20 25 30 Leu Gly Ser Gin Val Ala Pro Ser Tyr Leu Leu Arg Thr Gly Thr Glu 35 40 45 Pro Glu Thr Glu Leu lie Ala Val Ala Leu Asp Arg Gly Trp Ala Val 50 55 60 Val lie Thr Asp Tyr Glu Gly Leu Gly Thr Pro Gly Thr His Thr Tyr 65 7 0 75 80 Thr Val Gly Arg Ala Gin Gly His Ala Met Leu Asp Ala Ala Arg Ala 85 90 95 Ala Gin Arg Leu Pro Gly Ser Gly Leu Thr Thr Asp Cys Pro Val Gly 100 105 110 lie Trp Gly Tyr Ala Gin Gly Gly Gin Ala Ser Ala Phe Ala Gly Glu 115 120 125 Leu His Pro Thr Tyr Ala Pro Glu Leu Arg lie Arg Ala Ala Ala Ala
49 1237058 六 、申請專利範圍 130 135 140 Gly Ala Val Pro lie Asp Leu Leu Asp lie lie His Arg Asn Asp Gly 145 150 155 160 Val Phe Thr Gly Pro Val Leu Ala Gly Leu Val Gly His Ala Ala Ala 165 170 175 Tyr Pro Asp Leu Pro Phe Asp Glu Leu Leu Thr Glu Ala Gly Arg Thr 180 185 190 Ala Val Asp Gin Val Arg Glu Leu Gly Ala Pro Glu Leu Val Thr Arg 195 200 205 Phe Leu Gly Arg Glu Leu Ser Asp Phe Leu Asp Thr Ser Gly Leu Phe 210 215 220 Glu Gin Pro Arg Trp Arg Ala Arg Leu Ala Glu Ser Val Ala Gly Arg 225 230 235 240 Asn Gly Gly Pro Val Val Pro Thr Leu Val Tyr His Ser Thr Asp Asp 245 250 255 Glu lie Val Pro Phe Ala Phe Gly Glu Arg Leu Arg Asp Ser Tyr Arg 260 265 270 Ala Ala Gly Thr Pro Val Arg Trp His Pro Leu Ser Gly Leu Ala His 275 280 285 Phe Pro Ala Ala Leu Ala Ser Ser Arg Val Val Val Ser Trp Phe Asp 290 295 300 Glu His Phe Ser Glu Pro Ser Ala lie Ser Gly Pro Arg Asp Ala Arg 305 310 315 320 序列辨識號碼:15 Met Arg Lys Pro Val Arg lie Gly Val Leu Gly Cys Ala Ser Phe Ala 1 5 10 15 Trp Arg Arg Met Leu Pro Ala Met Cys Asp Val Ala Glu Thr Glu Val 20 25 30 Val Ala Val Ala Ser Arg Asp Pro Ala Lys Ala Glu Arg Phe Ala Ala 35 40 45 Arg Phe Glu Cys Glu Ala Val Leu Gly Tyr Gin Arg Leu Leu Glu Arg 50 55 60 Pro Asp lie Asp Ala Val Tyr Val Pro Leu Pro Pro Gly Met His Ala 65 70 75 80 Glu Trp lie Gly Lys Ala Leu Glu Ala Asp Lys His Val Leu Ala Glu 85 90 95 Lys Pro Leu Thr Thr Thr Ala Ser Asp Thr Ala Arg Leu Val Gly Leu 100 105 110 Ala Arg Arg Lys Asn Leu Leu Leu Arg Glu Asn Tyr Leu Phe Leu His 115 120 125 His Gly Arg His Asp Val Val Arg Asp Leu Leu Gin Ser Gly Glu lie
50 1237058 六 、申請專利範圍 130 135 140 Gly Glu Leu Arg Glu Phe Thr Ala Val Phe Gly lie Pro Pro Leu Pro 145 150 155 160 Asp Thr Asp lie Arg Tyr Arg Thr Glu Leu Gly Gly Gly Ala Leu Leu 165 170 175 Asp lie Gly Val Tyr Pro Ala Arg Ala Ala Arg His Phe Leu Leu Gly 180 185 190 Pro Leu Thr Val Leu Gly Ala Ser Ser His Glu Ala Gin Glu Ser Gly 195 200 205 Val Asp Leu Ser Gly Ser Val Leu Leu Gin Ser Glu Gly Gly Thr Val 210 215 220 Ala His Leu Gly Tyr Gly Phe Val His His Tyr Arg Ser Ala Tyr Glu 225 230 235 240 Leu Trp Gly Ser Arg Gly Arg lie Val Val Asp Arg Ala Phe Thr Pro 245 250 255 Pro Ala Glu Trp Gin Ala Val lie Arg lie Glu Arg Lys Gly Val Val 260 265 270 Asp Glu Leu Ser Leu Pro Ala Glu Asp Gin Val Arg Lys Ala Val Thr 275 280 285 Ala Phe Ala Arg Asp lie Arg Ala Gly Thr Gly Val Asp Asp Pro Ala 290 295 300 Val Ala Gly Asp Ser Gly Glu Ser Met lie Gin Gin Ala Ala Leu Val 305 310 315 320 Glu Ala lie Gly Gin Ala Arg Arg Cys Gly Ser Thr 325 330 序列辨識號碼:16 Met Ser Ser Ser Val Glu Ala Glu Ala Ser Ala Ala Ala Pro Leu Gly 1 5 10 15 Ser Asn Asn Thr Arg Arg Phe Val Asp Ser Ala Leu Ser Ala Cys Asn 20 25 30 Gly Met lie Pro Thr Thr Glu Phe His Cys Trp Leu Ala Asp Arg Leu 35 40 45 Gly Glu Asn Ser Phe Glu Thr Asn Arg lie Pro Phe Asp Arg Leu Ser 50 55 60 Lys Trp Lys Phe Asp Ala Ser Thr Glu Asn Leu Val His Ala Asp Gly 65 70 75 80 Arg Phe Phe Thr Val Glu Gly Leu Gin Val Glu Thr Asn Tyr Gly Ala 85 90 95 Ala Pro Ser Trp His Gin Pro lie lie Asn Gin Ala Glu Val Gly lie 100 105 110 Leu Gly lie Leu Val Lys Glu lie Asp Gly Val Leu His Cys Leu Met 51 1237058 六 、申請專利範圍 115 120 125 Ser Ala Lys Met Glu Pro Gly Asn Val Asn Val Leu Gin Leu Ser Pro 130 135 140 Thr Val Gin Ala Thr Arg Ser Asn Tyr Thr Gin Ala His Arg Gly Ser 145 150 155 160 Val Pro Pro Tyr Val Asp Tyr Phe Leu Gly Arg Gly Arg Gly Arg Val 165 170 175 Leu Val Asp Val Leu Gin Ser Glu Gin Gly Ser Trp Phe Tyr Arg Lys 180 185 190 Arg Asn Arg Asn Met Val Val Glu Val Gin Glu Glu Val Pro Val Leu 195 200 205 Pro Asp Phe Cys Trp Leu Thr Leu Gly Gin Val Leu Ala Leu Leu Arg 210 215 220 Gin Asp Asn lie Val Asn Met Asp Thr Arg Thr Val Leu Ser Cys lie 225 230 235 240 Pro Phe His Asp Ser Ala Thr Gly Pro Glu Leu Ala Ala Ser Glu Glu 245 250 255 Pro Phe Arg Gin Ala Val Ala Arg Ser Leu Ser His Gly lie Asp Ser 260 265 270 Ser Ser lie Ser Glu Ala Val Gly Trp Phe Glu Glu Ala Lys Ala Arg 275 280 285 Tyr Arg Leu Arg Ala Thr Arg Val Pro Leu Ser Arg Val Asp Lys Trp 290 295 300 Tyr Arg Thr Asp Thr Glu lie Ala His Gin Asp Gly Lys Tyr Phe Ala 305 310 315 320 Val lie Ala Val Ser Val Ser Ala Thr Asn Arg Glu Val Ala Ser Trp 325 330 335 Thr Gin Pro Met lie Glu Pro Arg Glu Gin Gly Glu lie Ala Leu Leu 340 345 350 Val Lys Arg lie Gly Gly Val Leu His Gly Leu Val His Ala Arg Val 355 360 365 Glu Ala Gly Tyr Lys Trp Thr Ala Glu lie Ala Pro Thr Val Gin Cys 370 375 380 Ser Val Ala Asn Tyr Gin Ser Thr Pro Ser Asn Asp Trp Pro Pro Phe 385 390 395 400 Leu Asp Asp Val Leu Thr Ala Asp Pro Glu Thr Val Arg Tyr Glu Ser 405 410 415 lie Leu Ser Glu Glu Gly Gly Arg Phe Tyr Gin Ala Gin Asn Arg Tyr 420 425 430 Arg Ue lie Glu Val His Glu Asp Phe Ala Ala Arg Pro Pro Ser Asp
1237058 -Λ~ /、 、申請專利範圍 435 440 445 Phe Arg Trp Met Thr Leu Gly Gin Leu Gly Glu Leu Leu Arg Ser Thr 450 455 460 His Phe Leu Asn He Gin Ala Arg Ser Leu Val Ala Ser Leu His Ser 465 4 70 475 480 Leu Trp Ala Leu Gly Arg 485 序列辨識號碼:17 Val lie Leu Gly Met Leu Pro Gly Cys Ser lie Ala lie Gly Glu Phe 1 5 10 15 Met Arg Val Leu Phe Thr Pro Leu Pro Ala Ser Ser His Phe Phe Asn 20 25 30 Leu Val Pro Leu Ala Trp Ala Leu Arg Ala Ala Gly His Glu Val Arg 35 40 45 Val Ala lie Cys Pro Asn Met Val Ser Met Val Thr Gly Ala Gly Leu 50 55 60 Thr Ala Val Pro Val Gly Asp Glu Leu Asp Leu lie Ser Leu Ala Ala 65 70 75 80 Lys Asn Glu Leu Val Leu Gly Ser Gly Val Ser Phe Asp Glu Lys Gly 85 90 95 Arg His Pro Glu Leu Phe Asp Glu Leu Leu Ser lie Asn Ser Gly Arg 100 105 110 Asp Thr Asp Ala Val Glu Gin Leu His Leu Val Asp Asp Arg Ser Leu 115 120 125 Asp Asp Leu Met Gly Phe Ala Glu Lys Trp Gin Pro Asp Leu Val Val 130 135 140 Trp Asp Ala Met Val Cys Ser Gly Pro Val Val Ala Arg Ala Leu Gly 145 150 155 160 Ala Arg His Val Arg Met Leu Val Ala Leu Asp Val Ser Gly Trp Leu 165 170 175 Arg Ser Gly Phe Leu Glu Tyr Gin Glu Ser Lys Pro Pro Glu Gin Arg 180 185 190 Val Asp Pro Leu Gly Thr Trp Leu Gly Ala Lys Leu Ala Lys Phe Gly 195 200 205 Ala Thr Phe Asp Glu Glu lie Val Thr Gly Gin Ala Thr lie Asp Pro 210 215 220 lie Pro Ser Trp Met Arg Leu Pro Val Asp Leu Asp Tyr lie Ser Met 225 230 235 240 Arg Phe Val Pro Tyr Asn Gly Pro Ala Val Leu Pro Glu Trp Leu Arg 245 250 255 Glu Arg Pro Thr Lys Pro Arg Val Cys lie Thr Arg Gly Leu Thr Lys
53 1237058 六 、申請專利範圍 260 265 270 Arg Arg Leu Ser Arg Val Thr Glu Gin Tyr Gly Glu Gin Ser Asp Gin 275 280 285 Glu Gin Ala Met Val Glu Arg Leu Leu Arg Gly Ala Ala Arg Leu Asp 290 295 300 Val Glu Val lie Ala Thr Leu Ser Asp Asp Glu Val Arg Glu Met Gly 305 310 315 320 Glu Leu Pro Ser Asn Val Arg Val His Glu Tyr Val Pro Leu Asn Glu 325 330 335 Leu Leu Glu Ser Cys Ser Val lie lie His His Gly Ser Thr Thr Thr 340 345 350 Gin Glu Thr Ala Thr Val Asn Gly Val Pro Gin Leu lie Leu Pro Gly 355 360 365 Thr Phe Trp Asp Glu Ser Arg Arg Ala Glu Leu Leu Ala Asp Arg Gly 370 375 380 Ala Gly Leu Val Leu Asp Pro Ala Thr Phe Thr Glu Asp Asp Val Arg 385 390 395 400 Gly Gin Leu Ala Arg Leu Leu Asp Glu Pro Ser Phe Ala Ala Asn Ala 405 410 415 Ala Leu lie Arg Arg Glu lie Glu Glu Ser Pro Ser Pro His Asp lie 420 425 430 Val Pro Arg Leu Glu Lys Leu Val Ala Glu Arg Glu Asn Arg Arg Thr 435 440 445 Gly Gin Ser Asp Gly His Pro 450 455 序列辨識號碼:18 Met Gin Ser Arg Lys Thr Arg Ala Leu Gly Lys Gly Arg Ala Arg Val 1 5 10 15 Thr Ser Cys Asp Asp Thr Cys Ala Thr Ala Thr Glu Met Val Pro Asp 20 25 30 Ala Lys Asp Arg lie Leu Ala Ser Val Arg Asp Tyr His Arg Glu Gin 35 40 45 Glu Ser Pro Thr Phe Val Ala Gly Ser Thr Pro lie Arg Pro Ser Gly 50 55 60 Ala Val Leu Asp Glu Asp Asp Arg Val Ala Leu Val Glu Ala Ala Leu 65 70 75 80 Glu Leu Arg lie Ala Ala Gly Gly Asn Ala Arg Arg Phe Glu Ser Glu 85 90 95 Phe Ala Arg Phe Phe Gly Leu Arg Lys Ala His Leu Val Asn Ser Gly 100 105 110 Ser Ser Ala Asn Leu Leu Ala Leu Ser Ser Leu Thr Ser Pro Lys Leu
1237058 -Λ- /、 、申請專利範圍 115 120 125 Gly Glu Ala Arg Leu Arg Pro Gly Asp Glu Val lie Thr Ala Ala Val 130 135 140 Gly Phe Pro Thr Thr lie Asn Pro Ala Val Gin Asn Gly Leu Val Pro 145 150 155 160 Val Phe Val Asp Val Glu Leu Gly Thr Tyr Asn Ala Thr Pro Asp Arg 165 170 175 lie Lys Ala Ala Val Thr Glu Arg Thr Arg Ala lie Met Leu Ala His 180 185 190 Thr Leu Gly Asn Pro Phe Ala Ala Asp Glu lie Ala Glu lie Ala Lys 195 200 205 Glu His Glu Leu Phe Leu Val Glu Asp Asn Cys Asp Ala Val Gly Ser 210 215 220 Thr Tyr Arg Gly Arg Leu Thr Gly Thr Phe Gly Asp Leu Thr Thr Val 225 230 235 240 Ser Phe Tyr Pro Ala His His He Thr Ser Gly Glu Gly Gly Cys Val 245 250 255 Leu Thr Gly Ser Leu Glu Leu Ala Arg lie lie Glu Ser Leu Arg Asp 260 265 270 Trp Gly Arg Asp Cys Trp Cys Glu Pro Gly Val Asp Asn Thr Cys Arg 275 280 285 Lys Arg Phe Asp Tyr His Leu Gly Thr Leu Pro Pro Gly Tyr Asp His 290 295 300 Lys Tyr Thr Phe Ser His Val Gly Tyr Asn Leu Lys Thr Thr Asp Leu 305 310 315 320 Gin Ala Ala Leu Ala Leu Ser Gin Leu Ser Lys lie Ser Ala Phe Gly 325 330 335 Ser Ala Arg Arg Arg Asn Trp Arg Arg Leu Arg Glu Gly Leu Ser Gly 340 345 350 Leu Pro Gly Leu Leu Leu Pro Val Ala Thr Pro His Ser Asp Pro Ser 355 360 365 Trp Phe Gly Phe Ala lie Thr lie Ser Ala Asp Ala Gly Phe Thr Arg 370 3 75 380 Ala Ala Leu Val Asn Phe Leu Glu Ser Arg Asn lie Gly Thr Arg Leu 385 390 395 400 Leu Phe Gly Gly Asn lie Thr Arg His Pro Ala Phe Glu Gin Val Arg 405 410 415 Tyr Arg Ue Ala Asp Ala Leu Thr Asn Ser Asp lie Val Thr Asp Arg 420 425 430 Thr Phe Trp Val Gly Val Tyr Pro Gly lie Thr Asp Gin Met lie Asp
55 1237058 六 、申請專利範圍 435 440 445 Tyr Val Val Glu Ser lie Ala Glu Phe Val Ala Lys Ser Ser 450 455 460 序列辨識號碼:19 Val lie Asn Leu His Gin Pro lie Leu Gly Thr Glu Glu Leu Asp Ala 1 5 10 15 lie Ala Glu Val Phe Ala Ser Asn Trp lie Gly Leu Gly Pro Arg Thr 20 25 30 Arg Thr Phe Glu Ala Glu Phe Ala His His Leu Gly Val Asp Pro Glu 35 40 45 Gin Val Val Phe Leu Asn Ser Gly Thr Ala Ala Leu Phe Leu Thr Val 50 55 60 Gin Val Leu Asp Leu Gly Pro Gly Asp Asp Val Val Leu Pro Ser lie 65 70 75 80 Ser Phe Val Ala Ala Ala Asn Ala lie Ala Ser Ser Gly Ala Arg Pro 85 90 95 Val Phe Cys Asp Val Asp Pro Arg Thr Leu Asn Pro Thr Leu Asp Asp 100 105 110 Val Ala Arg Ala lie Thr Pro Ala Thr Lys Ala Val Leu Leu Leu His 115 120 125 Tyr Gly Gly Ser Pro Gly Glu Val Thr Ala lie Ala Asp Phe Cys Arg 130 135 140 Glu Lys Gly Leu Met Leu lie Glu Asp Ser Ala Cys Ala Val Ala Ser 145 150 155 160 Ser Val His Gly Thr Ala Cys Gly Thr Phe Gly Asp Leu Ala Thr Trp 165 170 175 Ser Phe Asp Ala Met Lys lie Leu Val Thr Gly Asp Gly Gly Met Phe 180 185 190 Tyr Ala Ala Asp Pro Glu Leu Ala His Arg Ala Arg Arg Leu Ala Tyr 195 200 205 His Gly Leu Glu Gin Met Ser Gly Phe Asp Ser Ala Lys Ser Ser Asn 210 215 220 Arg Trp Trp Asp lie Arg Val Glu Asp lie Gly Gin Arg Leu lie Gly 225 230 235 240 Asn Asp Met Thr Ala Ala Leu Gly Ser Val Gin Leu Arg Lys Leu Pro 245 250 255 Glu Phe lie Asn Arg Arg Arg Glu lie Ala Thr Gin Tyr Asp Arg Leu 260 265 270 Leu Ser Asp Val Pro Gly Val Leu Leu Pro Pro Thr Leu Pro Asp Gly 2 75 280 285 His Val Ser Ser His Tyr Phe Tyr Trp Val Gin Leu Ala Pro Glu He
1237058 -Λ- /、 、申請專利範圍 290 295 300 Arg Asp Gin Val Ala Gin Gin Met Leu Glu Arg Gly lie Tyr Thr Ser 305 310 315 320 Tyr Arg Tyr Pro Pro Leu His Lys Val Pro lie Tyr Arg Ala Asp Cys 325 330 335 Lys Leu Pro Ser Ala Glu Asp Ala Cys Arg Arg Thr Leu Leu Leu Pro 340 345 350 Leu His Pro Ser Leu Asp Asp Ala Glu Val Arg Thr Val Ala Asp Glu 355 360 365 Phe Gin Lys Ala Val Glu His His lie Ser Gin Arg Ser Pro Leu Arg 370 375 380 Lys 385 序列辨識號碼:20 Met Ser Arg Val Ser Asp Thr Phe Ala Glu Thr Ser Ser Val Tyr Ser 1 5 10 15 Pro Asp His Ala Asp lie Tyr Asp Ala lie His Ser Ala Arg Gly Arg 20 25 30 Asp Trp Ala Ala Glu Ala Gly Glu Val Val Gin Leu Val Arg Thr Arg 35 40 45 Leu Pro Glu Ala Gin Ser Leu Leu Asp Val Ala Cys Gly Thr Gly Ala 50 55 60 His Leu Glu Arg Phe Arg Ala Glu Tyr Ala Lys Val Ala Gly Leu Glu 65 70 75 80 Leu Ser Asp Ala Met Arg Glu lie Ala lie Arg Arg Val Pro Glu Val 85 90 95 Pro lie His lie Gly Asp lie Arg Asp Phe Asp Leu Gly Glu Pro Phe 100 105 110 Asp Val lie Thr Cys Leu Cys Phe Thr Ala Ala Tyr Met Arg Thr Val 115 120 125 Asp Asp Leu Arg Arg Val Thr Arg Asn Met Ala Arg His Leu Ala Pro 130 135 140 Gly Gly Val Ala Val lie Glu Pro Trp Trp Phe Pro Asp Lys Phe lie 145 150 155 160 Asp Gly Phe Val Thr Gly Ala Val Ala His His Gly Glu Arg Val lie 165 170 175 Ser Arg Leu Ser His Ser Val Leu Glu Gly Arg Thr Ser Arg Met Thr 180 185 190 Val Arg Tyr Thr Val Ala Glu Pro Thr Gly lie Arg Asp Phe Thr Glu 195 200 205 Phe Glu lie Leu Ser Leu Phe Thr Glu Asp Glu Tyr Thr Ala Ala Leu
57 1237058 六 、申請專利範圍 210 215 220 Glu Asp Ala Gly lie Arg Ala Glu Tyr Leu Pro Gly Ala Pro Asn Gly 225 230 235 240 Arg Gly Leu Phe Val Gly He Arg Asn 245 序列辨識號碼:21 Met Val Leu Val Pro Arg Arg Phe Arg Ala Thr Leu Glu Ser Met Ser 1 5 10 15 Glu Gin Thr lie Ala Leu Val Thr Gly Ala Asn Lys Gly lie Gly Tyr 20 25 30 Glu lie Ala Ala Gly Leu Gly Ala Leu Gly Trp Ser Val Gly lie Gly 35 40 45 Ala Arg Asp His Gin Arg Gly Glu Asp Ala Val Ala Lys Leu Arg Ala 50 55 60 Asp Gly Val Asp Ala Phe Ala Val Ser Leu Asp Val Thr Asp Asp Ala 65 70 75 80 Ser Val Ala Ala Ala Ala Ala Leu Leu Glu Glu Arg Ala Gly Arg Leu 85 90 95 Asp Val Leu Val Asn Asn Ala Gly lie Ala Gly Ala Trp Pro Glu Glu 100 105 110 Pro Ser Thr Val Thr Pro Ala Ser Leu Arg Ala Val Val Glu Thr Asn 115 120 125 Val lie Gly Val Val Arg Val Thr Asn Ala Met Leu Pro Leu Leu Arg 130 135 140 Arg Ser Glu Arg Pro Arg lie Val Asn Gin Ser Ser His Val Ala Ser 145 150 155 160 Leu Thr Leu Gin Thr Thr Pro Gly Val Asp Leu Gly Gly lie Ser Gly 165 170 175 Ala Tyr Ser Pro Ser Lys Thr Phe Leu Asn Ala lie Thr lie Gin Tyr 180 185 190 Ala Lys Glu Leu Ser Asp Thr Asn lie Lys lie Asn Asn Ala Cys Pro 195 200 205 Gly Tyr Val Ala Thr Asp Leu Asn Gly Phe His Gly Thr Ser Thr Pro 210 215 220 Ala Asp Gly Ala Arg lie Ala lie Arg Leu Ala Thr Leu Pro Asp Asp 225 230 235 240 Gly Pro Thr Gly Gly Met Phe Asp Asp Ala Gly Asn Val Pro Trp 245 250 255 序列辨識號碼:22 Met Glu Thr Arg Glu Leu Arg Tyr Phe Val Ala Val Ala Glu Glu Leu
58 1237058 六 、申請專利範圍 1 5 10 15 His Phe Gly Arg Ala Ala Gin Arg Leu Gly lie Ala Gin Pro Pro Leu 20 25 30 Ser Arg Thr lie Ala Gin Leu Glu Gin Arg Leu Gly Val Val Leu Leu 35 40 45 Gin Arg Thr Ser Arg Lys Val Ser Leu Thr Glu Ala Gly Ala Met Leu 50 55 60 Leu Thr Glu Gly Arg Ala lie Leu Gly Ala Leu Ala Ala Ala Glu Arg 65 70 75 80 Arg Thr Gin Arg Ala Ala Thr Ser Gin Pro Ser Leu Val Leu Ala Ala 85 90 95 Lys Ala Gly Ala Ser Gly Glu Leu Leu Ala Lys Leu Leu Asp Ala Tyr 100 105 110 Ala Ala Glu Pro Gly Ala Val Ala Val Asp Leu Leu Leu Cys Glu Ser 115 120 125 Gin Pro Gin Lys Thr Leu His Asp Gly Arg Ala Asp Val Ala Leu Leu 130 135 140 His Gin Pro Phe Asp Pro Thr Ala Glu Leu Asp lie Glu lie Leu Asn 145 150 155 160 Thr Glu Gin Gin Val Ala lie Leu Pro Thr Ser His Pro Leu Ala Ser 165 170 175 Glu Pro His Val Arg Met Ala Asp Val Ser Ser Leu Pro Asp Leu Pro 180 185 190 Leu Ala Arg Trp Pro Gly Pro Asp Gly Val Tyr Pro Asp Gly Pro Gly 195 200 205 Val Glu Val Arg Asn Gin Thr Gin Leu Phe Gin Met lie Ala Leu Gly 210 215 220 Arg Thr Thr Val Val Met Pro Glu Ser Ser Arg Val Asn Leu Leu Glu 225 230 235 240 Gly Leu Ala Ala Val Pro Val Leu Asp Ala Pro Asp Val Thr Thr Val 245 250 255 lie Ala Trp Pro Pro His Ser Arg Ser Arg Ala Leu Ala Gly Leu Val 260 265 270 Arg Val Ala Thr Leu Leu 275 序列辨識號碼:23 Met Met Leu Lys Arg His Arg Leu Thr Thr Ala lie Thr Gly Leu Leu 1 5 10 15 Gly Gly Val Leu Leu Val Ser Gly Cys Gly Thr Ala Ala Ala Leu Gin
-59 - 1237058 六 、申請專利範圍 20 25 30 Ser Ser Pro Ala Pro Gly His Asp Ala Arg Asn Val Gly Met Ala Ser 35 40 45 Gly Gly Gly Gly Gly Asp lie Gly Thr Ser Asn Cys Ser Glu Ala Asp 50 55 60 Phe Leu Ala Thr Ala Thr Pro Val Lys Gly Asp Pro Gly Ser Phe lie 65 70 75 80 Val Ala Tyr Gly Asn Arg Ser Asp Lys Thr Cys Thr lie Asn Gly Gly 85 90 95 Val Pro Asn Leu Lys Gly Val Asp Met Ser Asn Ser Pro lie Glu Asp 100 105 110 Leu Pro Val Glu Asp Val Arg Leu Pro Asp Ala Pro Lys Glu Phe Thr 115 120 125 Leu Gin Pro Gly Gin Ser Ala Tyr Ala Gly lie Gly Met Val Leu Ala 130 135 140 Asp Ser Gly Asp Pro Asn Ala His Val Leu Thr Gly Phe Gin Ser Ser 145 150 155 160 Leu Pro Asp Met Ser Glu Ala Gin Pro Val Asn Val Leu Gly Asp Gly 165 170 175 Asn Val Lys Phe Ala Ala Lys Tyr Leu Arg Val Ser Ser Leu Val Ser 180 185 190 Thr Ala Asp Glu Leu Arg 195 序列辨識號碼:24 Val Leu Ser Val Glu Lys Gly Arg Glu Ser Ala Thr Trp Thr Ala Val 1 5 10 15 Leu Glu Gly Thr Leu Glu Arg lie Thr Phe Ala Asn Glu Glu Ser Gly 20 25 30 Tyr Thr Val Ala Arg lie Asp Thr Gly Arg Gly Gly Asp Leu Val Thr 35 40 45 Val Val Gly Ala Leu Leu Gly Ala Gin Pro Gly Glu Ala Leu Arg Met 50 55 60 Arg Gly Arg Trp Gly Ser His Pro Gin Tyr Gly Arg Gin Phe His Val 65 70 75 80 Asp Asp Tyr Thr Thr Val Leu Pro Ala Thr Val Gin Gly lie Arg Arg 85 90 95 Tyr Leu Gly Ser Gly Leu lie Lys Gly lie Gly Pro Lys Leu Ala Glu 100 105 110 Lys lie Val Asp His Phe Gly Val Ala Ala Leu Asp Val lie Glu Gin 115 120 125 Glu Pro Ala Arg Leu lie Glu Val Pro Lys Leu Gly Pro Lys Arg Thr
60 1237058 六 、申請專利範圍 130 135 140 Lys Leu lie Ala Asp Ala Trp Glu Glu Gin Lys Ala lie Lys Glu Val 145 150 155 160 Met He Phe Leu Gin Gly Val Gly Val Ser Thr Ser Leu Ala Val Lys 165 170 175 lie Tyr Lys Gin Tyr His Asp Asp Ala lie Arg Thr Val Lys Glu Glu 180 185 190 Pro Tyr Arg Leu Ala Gly Asp Val Trp Gly lie Gly Phe Lys Thr Ala 195 200 205 Asp Thr lie Ala Lys Ala Val Gly lie Pro His Asp Ser Pro Gin Arg 210 215 220 Val Lys Ala Gly Leu Gin Phe Thr Leu Ser Glu Ser Thr Gly Asp Gly 225 230 235 240 Asn Cys Tyr Leu Pro Glu Asn Glu Leu lie Ala Glu Ala Val Lys lie 245 250 255 Leu Ala Val Asp Thr Gly Leu Val lie Glu Cys Leu Ala Glu Leu Val 260 265 270 Thr Glu Glu Gly Val Val Arg Glu Glu lie Pro Thr Asp Asp Asp Glu 275 280 285 Val Pro Thr Val Ala lie Tyr Leu Val Pro Phe His Arg Ala Glu Val 290 295 300 Ala Leu Ala Asn Gin Leu Ser Arg Leu Leu Asn Thr Ser Ala Asp Arg 305 310 315 320 Met Pro Val Phe Ala Asp Val Asp Trp His Lys Ala Leu Asp Trp Leu 325 330 335 Arg Arg Ala Thr Gly Ala Glu Leu Ala Glu Ala Gin Glu Arg Ala Val 340 345 350 Lys Leu Ala Leu Thr Glu Lys Val Ala Val Leu Thr Gly Gly Pro Gly 355 360 365 Cys Gly Lys Ser Phe Thr Val Arg Ser Ue lie Ala Leu Ala Gin Ala 370 375 380 Lys Lys Ala Lys Val lie Leu Ala Ala Pro Thr Gly Arg Ala Ala Lys 385 390 395 400 Arg Leu Thr Glu Leu Thr Gly His Asp Ala Ala Thr Val His Arg Leu 405 410 415 Leu Gin Leu Gin Pro Gly Gly Asp Ala Ala Tyr Asp Arg Asp Asn Pro 420 425 430 Leu Asp Ala Asp Leu Val Val Val Asp Glu Ala Ser Met Leu Asp Leu 435 440 445 Leu Leu Ala Asn Lys Leu Ala Lys Ala lie Ala Pro Gly Ala His Leu
61 1237058 六 、申請專利範圍 450 455 460 Leu Leu Val Gly Asp Val Asp Gin Leu Pro Ser Val Gly Ala Gly Glu 465 470 475 480 Val Leu Arg Asp Leu Leu Ala Pro Gly Thr Pro lie Pro His Val Arg 485 490 495 Leu Asn Glu Val Phe Arg Gin Ala Ala Glu Ser Gly Val Val Thr Asn 500 505 510 Ala His Arg lie Asn Ala Gly Asp Tyr Pro Leu Thr His Gly Leu Thr 515 520 525 Asp Phe Phe Leu Phe His Val Glu Glu Ser Glu Pro Thr Ala Glu Leu 530 535 540 Thr Val Asp Val Val Ala Arg Arg lie Pro Arg Lys Phe Arg Phe Asn 545 550 555 560 Pro Arg Thr Asp Val Gin Val Leu Ala Pro Met His Arg Gly Pro Ala 565 570 575 Gly Ala Gly Ala Leu Asn Gin Leu Leu Gin Glu Ala lie Thr Pro Ala 580 585 590 Arg Glu Gly Leu Pro Glu Arg Arg Phe Gly Gly Arg lie Phe Arg Val 595 600 605 Gly Asp Lys Val Thr Gin lie Arg Asn Asn Tyr Asp Lys Gly Ala Asn 610 615 620 Gly Val Phe Asn Gly Thr Gin Gly Val Val Ser Ala Leu Asp Asn Glu 625 630 635 640 Ala Gin Thr Met Thr Val Arg Thr Asp Glu Asp Glu Asp lie Asp Tyr 645 650 655 Asp Phe Thr Glu Leu Asp Glu Leu Val His Ala Tyr Ala Val Thr lie 660 665 670 His Arg Ser Gin Gly Ser Glu Tyr Pro Cys Val Val lie Pro Leu Thr 675 680 685 Thr Ser Ala Trp Met Met Leu Gin Arg Asn Leu Leu Tyr Thr Ala Val 690 695 700 Thr Arg Ala Lys Lys Val Val Val Leu Val Gly Ser Lys Lys Ala Leu 705 710 715 720 Gly Gin Ala Val Arg Thr Val Gly Ser Gly Arg Arg His Thr Ala Leu 725 730 735 Asp His Arg Leu Arg Arg Gly Gly Thr Gly Ser Arg Pro Ala Ala 740 745 750 序列辨識號碼:26 Met Arg He Leu Val Thr Gly Gly Ala Gly Phe lie Gly Ser His Tyr 1 5 10 15
62 1237058 六 、申請專利範圍 Val Arg Gin Leu Leu Gly Gly Ala Tyr Pro Ala Phe Ala Asp Ala Asp 20 25 30 Val Val Val Leu Asp Lys Leu Thr Tyr Ala Gly Asn Glu Ala Asn Leu 35 40 45 Ala Pro Val Ala Asp Asn Pro Arg Leu Lys Phe Val Cys Gly Asp lie 50 55 60 Cys Asp Arg Glu Leu Val Gly Gly Leu Met Ser Gly Val Asp Val Val 65 70 75 80 Val His Phe Ala Ala Glu Thr His Val Asp Arg Ser lie Thr Gly Ser 85 90 95 Asp Ala Phe Val lie Thr Asn Val Val Gly Thr Asn Val Leu Leu Gin 100 105 110 Ala Ala Leu Asp Ala Glu lie Gly Lys Phe Val His Val Ser Thr Asp 115 120 125 Glu Val Tyr Gly Ser lie Glu Asp Gly Ser Trp Pro Glu Asp His Ala 130 135 140 Leu Glu Pro Asn Ser Pro Tyr Ser Ala Ala Lys Ala Gly Ser Asp Leu 145 150 155 160 Leu Ala Arg Ala Tyr His Arg Thr His Gly Leu Pro Val Cys lie Thr 165 170 175 Arg Cys Ser Asn Asn Tyr Gly Pro Tyr Gin Phe Pro Glu Lys Val Leu 180 185 190 Pro Leu Phe lie Thr Asn Leu Met Asp Gly Ser Gin Val Pro Leu Tyr 195 200 205 Gly Asp Gly Leu Asn Val Arg Asp Trp Leu His Val Ser Asp His Cys 210 215 220 Arg Gly lie Gin Leu Val Ala Asp Ser Gly Arg Ala Gly Glu lie Tyr 225 230 235 240 Asn lie Gly Gly Gly Thr Glu Leu Thr Asn Asn Glu Leu Thr Glu Arg 245 250 255 Leu Leu Ala Glu Leu Gly Leu Asp Trp Ser Val Val Arg Pro Val Thr 260 265 270 Asp Arg Lys Gly His Asp Arg Arg Tyr Ser Val Asp His Ser Lys lie 275 280 285 Val Glu Glu Leu Gly Tyr Ala Pro Gin Val Asp Phe Glu Thr Gly Leu 290 295 300 Arg Glu Thr lie Arg Trp Tyr Gin Asp Asn Arg Asp Trp Trp Glu Pro 305 310 315 320 Leu Lys Ala Arg Ser Ala Val Ala Arg 325 序列辨識號碼:27
1237058 六 、申請專利範圍 Val His Arg Pro Gly Ser Gly Glu Leu Asp Val Thr Asp Ala Glu Glu 1 5 10 15 Val Ala Asp Ala Leu Gly Ser Phe Ala Glu Thr Ala Lys Asp Ala Glu 20 25 30 Leu Arg Pro Val Val lie Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala 35 40 45 Ala Glu Ser Asp Pro Asp Arg Ala Ala Arg lie Asn Ala Glu Gly Ala 50 55 60 Ala Ser Leu Ala Lys Ala Cys Arg Ser Ser Gly Leu Pro Leu Val His 65 70 75 80 Val Ser Thr Asp Tyr Val Phe Pro Arg Asp Gly Ala Arg Pro Tyr Glu 85 90 95 Pro Thr Asp Pro Thr Gly Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu 100 105 110 Glu Gly Glu Arg Ala Val Leu Glu Ser Gly Ala Arg Ala Trp Val Val 115 120 125 Arg Thr Ala Trp Val Tyr Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr 130 135 140 Met lie Arg Leu Ser Gly Glu Arg Asp Thr Leu Ser Val Val Asp Asn 145 150 155 160 Gin lie Gly Ser Pro Thr Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu 165 170 175 Glu Leu Ala Glu Arg Val Ala Glu Arg Arg Gly Pro Glu Gin Lys Val 180 185 190 Leu His Cys Thr Asn Ser Gly Gin Val Thr Trp Tyr Glu Phe Ala Arg 195 200 205 Ala lie Phe Ala Glu Phe Gly Leu Asp Glu Asn Arg Val His Pro Cys 210 215 220 Thr Thr Ala Asp Phe Pro Leu Pro Ala His Arg Pro Ala Tyr Ser Val 225 230 235 240 Leu Ser Asp Val Ala Trp Arg Glu Ala Gly Leu Thr Pro Met Arg Thr 245 250 255 Trp Arg Glu Ala Leu Ala Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu 260 265 270 Arg Thr Arg 275 序列辨識號碼:29 Met lie Tyr Tyr Pro Leu Ser Val Leu Met Leu Ala Gly lie Arg Asp 1 5 10 15 Val Leu Leu lie Ser Thr Pro Ala Asp Met Pro Leu Phe Gin Arg Leu 20 25 30
1237058 六 、申請專利範圍 Leu Gly Asn Gly Ser Gin Phe Gly lie Arg lie Glu Tyr Ala Glu Gin 35 40 45 Ser Gin Pro Asn Gly Leu Ala Glu Ala Phe Val lie Gly Ala Asp Phe 50 55 60 Val Gly Asp Asp Ser Val Ala Leu Val Leu Gly Asp Asn lie Phe Tyr 65 7 0 75 80 Gly Gin Gly Phe Ser Gly lie Leu Gin Gin Cys Val Arg Glu Leu Asp 85 90 95 Gly Cys Thr Leu Phe Gly Tyr Pro Val Arg Asp Pro Gin Arg Tyr Gly 100 105 110 Val Gly Glu Val Asp Asp Asp Gly Arg Leu Leu Ser lie Val Glu Lys 115 120 125 Pro Glu Arg Pro Lys Ser Asn Met Ala lie Thr Gly Leu Tyr Phe Tyr 130 135 140 Asp Asn Asp Val Val Arg lie Ala Lys Gly Leu Thr Pro Ser Ala Arg 145 150 155 160 Gly Glu Leu Glu lie Thr Asp Val Asn Leu Ala Tyr Leu Gin Glu Gly 165 170 175 Arg Ala His Leu Thr Lys Leu Gly Arg Gly Phe Ala Trp Leu Asp Thr 180 185 190 Gly Thr His Asp Ser Leu Val Glu Ala Ser Gin Phe Val Gin Val Leu 195 200 205 Glu His Arg Gin Gly Val Arg lie Ala Cys Leu Glu Glu lie Xaa Leu 210 215 220 Arg Met Gly Tyr lie Ser Ala Asp Asp Cys Phe Ala Leu Gly Val Lys 225 230 235 240 Leu Ala Lys Ser Gly Tyr Ser Glu Tyr Val Met Asp Val Ala Arg Asn 245 250 255 Ser Gly Ala Arg Gly 260 序列辨識號碼:33 Val Gin Val Arg Arg Leu Asp lie Thr Gly Ala Tyr Glu Phe Thr Pro 1 5 10 15 Lys Ala Phe Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gin Glu 20 25 30 Ala Ala Phe lie Asp Ala Thr Gly His Pro Leu Arg Val Ala Gin Thr 35 40 45 Asn His Ser Val Ser Ala Arg Asn Val lie Arg Gly Val His Phe Ser 50 55 60 Asp Val Pro Pro Gly Gin Ala Lys Tyr Val Tyr Cys Pro Gin Gly Ala 65 70 75 80
1237058 六、申請專利範圍 Leu Leu Asp Val Val lie Asp lie Arg Val Gly Ser Pro Thr Phe Gly 85 90 95 Arg Trp Glu Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr 100 105 110 Leu Ala Glu Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr 115 120 125 Val Met Thr Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His 130 135 140 Gly lie Asp Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu 145 150 155 160 Asp Gly Glu Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu 165 170 175 Ala Glu Ala Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu 180 185 190 Ala His Tyr Glu Gly Leu Arg Ser Pro Gly 195 200 ° 2.如申請專利範圍第1項之分離的DN A分子，其中該DN A 序列係擇自於由 spnA、spnB、spnC、spnD、spnE、 spnF 、spnG 、spnli 、spnl 、spnj、sprite 、spnL· 、 spnM、spnN、spnO、spnP、spnQ、spnR、spnS、 ORFL15、ORFL16、ORFR1、ORFR2、史賓多泡酵母 菌gii、史賓多泡酵母菌 、史賓多泡酵母菌和史賓多泡酵母菌免re所組成之 基因群組中，該等基因被載述於下面所示的序列辨識編 號：1之氮鹼基21 1 1 1-28898、28916-35374、35419-44931 ' 44966-59752 ' 59803-76569 ^ 20168- 20995、18541-19713、17749_18501、16556- 17743 ^ 14799-16418 ^ 13592-14785 > 12696- 13547 、 11530-12492 、 10436-11434 、 8967-10427 、 7083-8450 、 5363-6751 、 4168-5325 、 3416-4165 、 2024-2791 、 1135-1971 、 76932-77528 和 77729- 66 1237058 六、申請專利範圍 79984，序列辨識編號：28之氮鹼基334-1 1 19，序列辨 識編號：25之氮鹼基88-1077和1 165-1992，以及序列 辨識編號：32之氮鹼基226-834 :序列辨識編號：1 GATCTCCATG AAGCTCAAOG TAGGCACGGA CGGTCAGGTG GACTGGGTGA TCGCCCGCGA 60 CCTGCTGGCC GACGGGCTGA TCGCCGAGGC AGGCGAAGGC GATGIXjCGGA TCGGCCCTCG 120 ACGGGGTTTT CCGGGGTTGG TCGTGATCGA GATGAGCTCG CCGTCGGGGC AGGCCTCCTT 180 CGAGGTGAAT GCTGACCAGC TTGCX3GACTT CITGAACGAC ACCTACGACG TGGTCX3AACC 240 TGGTGATGAA CACCGGTGGh TGAACGTCGA CGAGGTGCTG AGCCAGCTGC TCTCGCCAAC 300 CTGTAATGGC CCAGCTCTCC CGAAGCGCCG CACGCCAAAG CGCTGGCTGC GGGACCTGGC 360 GGCX3CTGAAC ACCGCCACGC TGTGTCTCCG AGCTCCAGCT GGACCAC!GTC GGTGCCGTCC 420 GCCCX3GCTCG GTCAGGCCGA. AGGTGCTGAT CTTCTCCAGG CGCGCCAT03 GCGCAGGAAG 480 CGCroCTTCT GCTCCCGCCG CAGTACCGTC GTGTCATGGC CACX3GACAGC TTCGATTCCT 540 CGAAGCTACA GGCGGCCGTG GCATCGAGCG TCGCGTCGTC CGTCTCGGAA GTCAGCCGAG 600 ACGTCTACAC GCACCTGATT ACCXSAGGCTC CJGCAGTTGCG AGCCGATGAG ATCGTCCTCA 660 GCATTCTACG GACGAGTGTT GAGGAAAATA TCGCCACATT GCCGCACX^TT CTCGAATTCG 720 AGATTCCGTT GGGATATTCG CCGGGTCCTG CTGCGGTGTT GGAGTATCCG CGACGACTGG 780 CGAAACTVrTT CCATCAACGC GCTGATCAGG GCCAACCGCA TCGGGCACTT CCGCTrCCTG 840 TAGTGATGCC TCGACGAGAT CCGCCGCCAA TGCGCCX3ACG AGGCCGTATC C!GCAGCGACC 900 ACGCAACGAA 1X5CTCGCAAC CAGCTTCGGC TACATCGACC GCGTCACGGA GCAGATCGCC 960 GAAACCTACC AGCTCX3AACG GGACCGCTGG CTCCTGGCGA CX3GGACX3GCC GTGAGGTCTC 1020 TGCGGCATCC GCATAGCGTC TTCTCCCGCT GAGGCACATG AGGTGTTGCX5 CX5CGGTCGTT 1080 TCCGGCAGTC GCACGGCATT CGTCCTAGCT GCGGGCAATT GAGGGAGCGA AGATTTAGAG 1140 GAGTGTGGCC ACGCGGACCA AGCCGGCGAG TGCTCGGGAG CGGCTGTGGG GCGGCCAGGC 1200 GATGACTGTC GTCACGTCCG GCGCGTCTAG AACCGGTACO GCGGCGAGGC CTTCGAGCAG 1260 GTTGACGCGA CTGGATTCGG GCATGACCAC GGTAGTGCGG CCGAGTGCGA T(^TTTGGAA 1320 CAGTTGCGTC TGGTTGCGTA CTTCCACGCC GGGGCCATCT GGATAGACGC CGTCGGGGCC 1380 GGGCCAGCGC GCAAGCGGGA GATCCGGCAG TGAGCTGACA TCCGCCATCC GTACATGGGG 1440 CTCGCTGGCA AGCGGATGCG AGGTCGGAAG AATGGCGACT TGTTGCTCGG TGTTCAGAAT 1500 TTCGATGTCG AGTTCGGCCG TCGGGTCX3AA GGGTTGATGC AACAGCGCCA CX3TCX3GCCCG 1560 GCCGTCATGC AGCGTTTTCT GGGGCTGGGA ITCGCAGAGC AGCAGGTCGA CX3GCCACGGC 1620 TCCCGGCTCG GCGGCGTACG CX5TCGAGCAA CTTCGCCAGC AGCTCACCGG AGGCGCCX3GC 1680 CTTGGCAGCC AGGACTAGCG AGGGCTGGCT COTCGCGGCA CGCTGGGTGC GTCGCTCGGC 1740 TGCTGCCAGC GCGCCGAGGA TCGCCCGGCC TTCX3GTCAGC AGCATTGCCC CGGCTTCGGT 1800 GAGCGAGACT TTGCGGCTGG TGCGTTGCAG CAACACGACT CCGAGTCGTT GCTCGAGCTG 1860 GGCGATCGTC CGCGACAGCG GCGGCTGGGC GATGCCCAGG CGCTGGGCGG CCCGGCCX5AA 1920 GTGCAACTCC TCGGCGACTG CAACGAAGTA CCGCAACTCC CGCX3TCTCCA TCCGTCGAGC 1980 CTACCGCTGA TTCATATCAG CTGGGTATCG GTGTGAGACC TAGATGGIX3T TGGTTCCCCG 2040
1237058 六、申請專利範圍 CCGGTTTCGG GCCACGCTAG AAAGCATGAG CGAACAGACG ATTGCACTGG TCACCGGCGC 2100 AAACAAGGGA ATCGGATACG AGATCX3CGGC CGGGCTCX3GC GCGCTGGGGT GGAGCGTCGG 2160 AATCGGGGCA CGGGACCACC AGCGCGGGGA GGATGCCGTG GCGAAATTGC GTGCGGACGG 2220 CGTCGATGCX3 TTCX3CGGTAT CCCTGGACGT GACAGACX5AC GCGAGCGTCG CGGCTGCTGC 2280 GGCTCTGCTC GAGGAGCGCG CCGGCCGGCT CX5ATGTGCTG GTTAATAACG CCGGCATCGC 2340 CX3GGGCATGG CCGGAGGAGC CCTCX5ACCGT CACACCGGCG AGCCTCCGGG CX3GTGGTGGA 2400 GACCAACGTG ATCGGCX3TCG TTCGGGTTAC CAACX5CTATG CTCCCGTTGC TACGCCGCTC 2460 CGAGCX5CCCG CGGATCGTCA ACCAGTCCAG CCACX^TCGCT TCCCTGACCT TGCAAACCAC 2520 GCCGGGCGTC GACCTCX3GCG GGATCAGCGG AGCCTACTCA CCGTCGAAGA CX^TTCCTCAA 2580 CGCGATCACC ATCCAGTACG CCAAGGAACT CAGC!GATACC AACATCAAAA TCAACAACGC 2640 CTGCCCCGGC TACGTCGCGA CCGACCTTAA CGGCTTCCAC GGAACCAGCA CGCCGGCAGA 2700 CGGTGCCAGG ATCGCCATTC GGCTCX3CCAC GCTGCCAGAC GACGGCCCGA CCGGAGGCAT 2760 GTTCGACGAC GCCGGGAATG TGCCCTGGTG AGGCGCTCAG TCGGCGATGG TGCAATCGAA 2820 GTCGGAGAGG CTCGCTGCGA CCGGGTACGC CGAACAACAC CIOTTCCTGT GGGTACGGAT 2880 GTCGGCCTTC GCCJGTCTCGG TCATTGACAA CCTGTACTTC GGGCGCCGTT ACCGCCGGTG 2940 CGCC!GCGGTT GCCTGGCGAC ACTGGGCCAG CCGTGGCTCA CCGGCGGCTT AGGTCAGGCG 3000 TGGGCGGTTG CCAGCATGGC GGGTGCGGCT TTGCGTAGGT CX3GGTAGGCG CATCCGGCGC 3060 GGGAGCCGGT CX^AGTTCTTC GCCGATGGCC GGTGCTTTGG GGCTGCTCAG GAGCCGAACA 3120 CCTCCCAGCC GCAGGTGCCX5 GGCTGAACCG AGTGGTTCTC GTCGGCTCGG ATCACAACGT 3180 CTGCCGGAAC AGCTGCGGCG AGGTGGTCGC AGATTCGAGG CX3GGATCGTC CTCX3GCGACC 3240 TTGCCGACGA TCGCGGCTAG GGCCCAGGGC TTCGTCGACC TGGTTGGCAC CTAGATCACG 3300 ACGGTCAAAA CTIOCCGGCA TCAGAGACGA TCGAAGTGAT CCCGGGTCAC GTCX3GCTTAT 3360 CGGTCGAGTG AGTCCCGGGG CCTGCCCAGC CAGGTCTTGC GTCGTTGTTC CGGGCTCAGT 3420 TGCGGATTCC GACGAACAGG CCTCGGCCGT TCGGTGCTCC AGGAAGGTAT TCCXXGCGGA 3480 TCCCTGCGTC TTCGAGCGCG GCGGTGTACT CGTCCTCAGT GAACAGCGAG AGGATITCGA 3540 ACTCTGTGAA GTCCCGGATC CCGGTGGGTT CX3GCGACTGT GTAGCGGACG GTCATCCGGC 3600 TCGTACGGCC CTCCAGGACC GAGTGCGATA GCCGGCTGAT CACCCGCTCG CCGTGGTGCG 3660 CGACGGCTCC GGTGACGAAC CCGTCGATGA ACTTGTCGGG AAACCACCAG GGTTCGATGA 3720 CCGCGACTCC ACCAGGGGCC AGGTGCCGGG CCATGTTCCG CGTCACGCGT CGCAGGTCGT 3780 CAACGGTCCG CATGTAAGCC GCGGTAAAGC ACAGGCAGGT GATGACGTCG AATGGCTCGC 3840 CGAGGTCGAA ATCGCGGATG TCACCGATGT GAATCGGTAC CTCAGGGACT CGTCTGATCG 3900 CGATCTCCCG CATCX5CATCG GACAGTTCAA GCCCCGCX3AC CTTCGCGTAT TCGGCACGGA 3960 ATCGCTCTAG GTGCGCCCCG GTCCCACAGG CGACGTCX3AG TAGGGACTGT GCTTCGGGCA 4020 GCCTGGTGCG TACGAGCTGG ACTACTTCCC CGGCCTCGGC TGCCCAGTCC CGGCCACGCG 4080 CGGAGTGGAT CGCGTCGTAG ATGTCGGCAT GATCTGGGCT GTATACCGAG GAGGTTTCTG 4140 CGAATGTGTC GCTCACGCX3C GACATCCTCA CTTTCX3GAGT GGTG^TCTTT GGCTGATGTG 4200 GTGTTCGACG GCCTTCTGGA ACTCGTCAGC CACCGTGCGC ACCTCGGCGT CGTCAAGGCT 4260 TGGGTGCAGT GGTAGCAGGA GTGITCTGCG GCAGGCGTCC TCCGCAGAAG GCAGCTTGCA 4320 GTCCGCGCGG TAGATGGGGA CCTTGTGCAG GGGCGGGTAG CGGTAGCTCG TGTAGATGCC 4380 GCGTTCCAGC ATTTGCTGCG CCACCTGGTC GCGGATCTCC GGAGCCAGCT GGACCCAGTA 4440 GAAGTAGTCT GACGAGACGT GCCCATCCGG TAGCGTCGGC GGTAGGAGGA CACCCGGCAC 4500
68 1237058 六、申請專利範圍 ATCGGAAAGC AACCGGTCX5T ACTGCGTAGC GATTTCTCTA CGCCTGTTGA TGAATTCTGG 4560 CAGTTTGCGC AGCTGCACGC TGCCAAGCGC TGCCGTCATG TCGTTCCCGA TCAGCCGCTG 4620 GCCGATGTCT TCGACX5CGAA TATCCCACCA GCGGTTGGAA GACTTGGCCG AATCGAATCC 4680 GCTCATCTGC TCAAGACCGT GGTAGGCGAG TCGTCITGCG CGGTGCGCGA GCTCCGGATC 4740 CGCCGCGTAG AACATGCCCC CATCCCCGGT GACCAGGATC ITCATCGCAT CGAAACTCCA 4800 CGTGGCGAGG TCACCAAAGG TTCCGCT^GC GGTGCCGTGC ACGGACGATG CCACCGCGCA 4860 GGOSGAGTCC TCGATGAGCA TGAGGCCCTT TTCACGGCAG AAATCGGCGA TCGCGGTGAC 4920 TTCTCCCX3GC GATCCTCCAT AGTGGAGCAG CAATACGGCC TTGGTCGCCG GCGTGATGGC 4980 CCTCGCCACA TCATCCAGCG TGGGGTTCAA CGTCCGGGGG TCGACGTCGC AGAACACCGG 5040 GCGGGCACCO GAGGATGCGA TGGCGTTGGC CGCCGCCACG AAGCTTATCG AAGGAAGTAC 5100 CACGTCGTCG CCTGGGCCGA GGTCJGAGCAC CTGCACXSGTA AGGAACAGCG CGGCAGTCCC 5160 CGAGTTGAGG AACACGACCT GTTCGGGATC CACTCCCAGG TGGTGGGCGA ATTCGGCCTC 5220 GAACGTCCGG GTGCGCGGCC CXSAGCCCX^AT CCAGTTGGAG GCGAACACCT CCGCGATCGC 5280 GTCGAGTTCT TCGGTGCCGA GGATCGGCTG GTGCAGGTTG ATCACGTTGC TGAAATCCTC 5340 CGAGATGCCG CCATGCTGGA TGCTAGGAAC TCTTGGCCAC GAATTCAGCXS ATTGAITCGA 5400 CGACGTAGTC GATCATITGG TCCGTTATGC CTGGGTAGAC GCCGACCCAG AAGG1TCX3GT 5460 CGGTGACGAT GTCGCTGTTG GTGAGCX3CGT CGGCGATCCX3 GTACCGCACC TGCTCGAAGG 5520 CCGGGTGCCO GGTGATGTTA CCX5CCGAACA GCAGTCGGGT GCCGATGTTG CGGGATTCCA 5580 GGAAGTTCAC CAGGGCGGCA CGGGTGAACC CGGCGTCC!GC ACTGATGGTG ATCGCAAACC 5640 CGAACCAGCT CGGGTCGCTG TGCGGTGTGG CTACCGGCAG CAGCAGGCCC GGCAACCCGG 5700 ACAGCCCTTC GCGCAACCGT CGCCAGTTAC GGCGGCGTGC CGACCCJGAAT GCX3GAAATCT 5760 TGCTCAACTG GCTCAGCGCA AGTGCGGCCT GCAGGTCX3GT GGTCITGAGG TTGTAACCGA 5820 CGTGGGAGAA CGTGTACTTG TGGTCGTAGC CCGGTGGAAG GGTACCGAGG TGGTAGTCGA 5880 ACCTCTTGCG GCAGGTGTTG TCCACGCCGG GCTCGCACCA GCAATCCCGT CCCCAGTCAC 5940 GCAGCGACTC GATGATGCGA GCCAATTCCA GGCTGCCGGT CAACACGCAG CCACCCTCX3C 6000 CGCTGGTGAT GTGATGGGCA GGATAGAAGC TGACCGTTGT CAGGTCGCCG AAGGTTCCGG 6060 TCAGCCGTCC CCGGTAGGTG GATCCCACCG CATCACAGTT GTCTTCGACG AGGAACAGCT 6120 CGTGTTCTTT TGCGATCTCC GCGATTTCGT CAGCGGCGAA GGGGTTGCCC AGGGTGTGCG 6180 CCAGCATGAT GGCTCGCGTC CGTTCCGTGA CGGCGGCCTT GATGCGGTCT GGCGTTGCGT 6240 TGTAGGTGCC CAGTTCCACG TCGACGAATA CCGGGACX3AG TCCGTTTTGG ACCGCCGGAT 6300 TGATCGTCGT GGGGAAGCCG ACCGCCGCAG TGATCACTTC GTCGCCGGGC CGCAGTCGTG 6360 CCTCGCCGAG TTTGGGGGAG GTAAGCGAAC TCAGTGCCAG GAGATTGGCC GAOGAACCJGG 6420 AGTTGACGAG ATGAGCCTTG CGGAGGCCGA AGAAGCGGGC GAACTCGCTC TCX3AATCGCC 6480 GTGCATTCCC GCCCGCGGCG ATCCGGAGCT CCAGCGCGGC TTCCACCAGT GCCACCCGGT 6540 CGTCCTCGTC GAGCACGGCG CCCGATGGCC GGATCGGCX3T CGATCCAGCC ACGAAGGTCO 6600 GGGATTCCTG TTCGCGGTGG TAATCGCGTA CGGATGCCAA TATCCGGTCC TTGGCATCCO 6660 GCACCATCTC AGTAGCGGTA GCGCAAGTGT CGTCACACGA AGTCACTCTG GCGCGCCCTT 6720 TCCCCAGCGC TCIOGTTTTC CX3GCTCTGCA TGCAGGCX5AC GATCAGTCTT CGCGCCTTGC 6780 CTTCAGGAGA TCAGCGATGC CCGTGGCGAA TCGCGTTATG ACOTCCCAGC GGGACAGTGT 6840 GCTGTCTCGG CGCCTTACAC CTTCCTGCCC TGGTTCGATG CGGTGCGGGA CATCAGGACA 6900 GCGGAGCAAG GAGAAGCGCT CATTGACTCA GAAATCCTCG ATCTACCCGG CACACCCGAC 6960
69 1237058 六、申請專利範圍 TCGGTAGAGC CCAGGCTAGC GGGAACGACC TGCTCGCGCT TGTCT^GATC GCTACCATCA 7020 CCTGGAAGGC CTAAGATTTG GCTTGCGAAA GCGGCGTTTC CCX3GGGGATA TCAGAGATTT 7080 CTGTGATTCT TGGCATGCTT CCCGGGTGTT CAATTGCGAT CGGAGAGTTC ATGCGTGTCC 7140 TGTTCACCCC GCTGCCGGCG AGTTCGCACT TCTTCAACCT GGTGCCGTTG GCGTGGGCGT 7200 TGCGTGCCGC GGGGCACGAG GTCCGTGTCG CCATCTGCCC GAATATGGTG TCGATGGTCA 7260 CCGGAGCAGG ACTCACCX3CG GTTCCCGTCX5 GCGACGAGCT CGACCTCATC TCCTTGGCGG 7320 CCAAGAACGA ACTCGTTCTC GGCAGCGGGG TCTCGTTCGA CGAGAAGGGG CGGCATCCGG 7380 AACTCTTCGA CGAGCTGCTG TCAATCAACT CCX3GCAGA.GA CACGGACGCC GTGGAGCAAC 7440 TCCACCITGT GGATGACCGA TCGCTGGACG ATCTCATGGG GTTCX5CCGAG AAATGGCAGC 7500 CTGATCTCGT TGTGTGGGAC GCTATGGTGT GTTCGGGGCC AGTTGTGGCG CGAGCGCTCG 7560 GCGCACGACA COTGCX3GATG CTCGTCGCCC TCX5ATGTGTC GGGGTGGCTG CGGTCCGGTT 7620 TCCTCX3AATA CCAGGAATCG AAGCCGCCTG AGCAGCGCGT CGACCCXKTC GGGACGTGGC 7680 TGGGAGCGAA GCTCX3CCAAG TTCGGAGCCA CGTTCGATGA AGAGATCGTG ACX^3GCCAAG 7740 CGACCATAGA TCCGATTCCA TCCTGGATGC GCCTGCCTGT GGACTTGGAC TACATCTCGA 7800 TGCGTITCX3T GCCGTACAAC GGTCCGGCGG TGTTGCCGGA GTGGTTGCX^： GAACGACCGA 7860 CGAAGCCXXG CGTCTGCATC ACGCGCGGGC TGACCAAGCO GCX3GCTGAGC AGGGTGACCG 7920 AACAGTACGG GGAGCAAAGT GACCAGGAAC AAGCAATGGT GGAAAGGTTG TTGCGCGGCG 7980 CGGCCAGGCT CX3ACGTCX3AG GTGATCGCCA CCITGTCTGA CGACGAAGTA CGGGAGATGG 8040 GGGAGTTGCC CTCGAACGTC CGGGTCCACG AATACGTACC GCTCAACXSAA CTGCTGGAGT 8100 CGTGTTCAGT GATCATCCAT CATGGCTCGA CGACGACGCA GGAAACCGCC ACGGTCAACG 8160 GCGTACCGCA GITGATTCTC CCTGGGACCT TCTGGGACGA ATCTCGTAGG GCGGAGCTCC 8220 TAGCCGATCG GGGAGCCGGT CTGGTCCTCO ACCCCGCGAC GTTTACCGAA GACX3ACGTGC 8280 GAGGTCAGCT GGCCCGCCTG CTCGACGAGC CGTCGTTCGC TGCCAACGCG GCGCTGATCC 8340 GCCGTGAAAT CGAGGAAAGT CCCAGCCCGC ACGACATCGT TCCACGTCTG GAAAAGCTAG 8400 TTGCCGAACG TGAGAACCGC CGCACTGGGC AGTCTGATGG CCATCCGTGA GCAACGTGTG 8460 GCCGGAAACA TGGACGCCGG GGTTTGGCAG GTGTTCATCG CTGTTGCGTC GACTCGGATT 8520 CCGCCGTGAC CGGGACGATG CCAGGCGAGT CCCGAAGTCA GATTCTTGTC CAGAATCGTC 8580 CAATGGGGTG TTGATCTCCC CAGAGGTTTG CX5CTCCAACC GATTTCCGAC GAGGATCGTG 8640 GCGCCCGCTG AGCAACGACT ACCGTGCGGT CGAGACATAC CGCTGTGCGC CAGGAGCGAA 8700 GGTGGG1TGC CCGATCACCG TGCTGGTGGT AGATGCCGAG CCGAAGGTCA CCTTGGATGA 8760 GGCGGAAGCC TGGCGAGAGC ACACCGAGGC CGTGGCCGAC GTCCGTGTCT TCTCCGGCGG 8820 GCATTTCTTC ATGACCGAAC GCCAGGACGA GGTGCTCGCG GTCCTTACGG GCGGATCGCT 8880 TCGATGATCC TCGCCAGGCC GCTGGACCAG ACCGCGACGC CCCTGGGAGC CGGCGTGCAC 8940 ATCGTCACGG CAGTGAGGGA TTGGGCATGA GCAGTTCTGT OSAAGCTGAG GCAAGTGCTG 9000 CTGCGCCGCT CGGCAGCAAC AACACGCGGC GGTTCGTCGA CTCTGCXiCTG AGCGCTTGCA 9060 ATGGCATGAT TCCX3ACCACG GAGTTCCACT GCTGGCTCGC CGATCGGCTG GGCGAGAACA 9120 GCTTCGAGAC CAATCGCATC CCGTTCGACC GCCTGTCGAA ATGGAAATTC GATGCCAGCA 9180 CGGAGAACCT GGTTCATGCC GACGGTAGGT TCTTCACGGT AGAAGGCCTG CAGGTCGAGA 9240 CCAACTATGG CGCGGCACCC AGCTGGCACC AGCCGATCAT CAACCAGGCT GAAGTAGGTA 9300 TCCTCGGCAT TCTCGTCAAG GAGATCGACG GCGTGCTGCA CTGCCTCATG TCAGCAAAGA 9360 TGGAACCGGG CAACGTCAAC GTCCTGCAGC TCTCGCCGAC GGTTCAGGCA ACTCGGAGCA 9420
70 1237058 六、申請專利範圍 ACTACACGCA GGCACACCGT GGCAGCGTTC CGCCCTATGT GGACTACTTC CTCGGGCGGG 9480 GCCGCGGCCG CGTGCTGGTA GACGTGCTCC AGTCTGAACA GGGGTCCTGG TTCTACCGGA 9540 AGCGCAACCG GAACATGGTG GTGGAAGTCC AGGAGGAAGT GCCAGTCCTG CCAGACTTCT 9600 GCTGGTTGAC GCTCGGCCAG GTGCTGGCTC TCCTTCGTCA GGACAAGATC GTCAACATGG 9660 ACACCCGGAC GGTGCTGTCT TGCATCCCGT TCCACX5ATTC CGCCACCX3GA CCCGAACTAG 9720 CCGCCTCGGA GGAGCCCTTC CGACAGGCGG TGGCCAGGTC GCTCTCGCAC GGCATCGATT 9780 CGTCGAGTAT CTCCGAGGCG GTCGGTTGGT TCGAGGAAGC CAAGGCCCGC TACCGCTTGC 9840 GGGCAACGCG CGTTCCGCTG AGCAGGGTCG ACAAGTGGTA TCGCACCGAT ACCGAGATCG 9900 CCCACCAGGA CGGCAAGTAC TTCGCGGTGA TCGCGGTGTC GGTGTCCGCG ACCAATCGTG 9960 AGGTCGCCAG CTGGACGCAG CCGATGATCG AACCGCGAGA ACAAGGTGAG ATCGCACTGT 10020 TGGTCAAGCG GATCGGCGGA GTGCTGCACG GTTTGGTCCA CGCTCGGGTG GAGGCTGGGT 10080 ATAAGTGGAC TGCGGAAATC GCTCCCACGG TCCAGTGCAG TGTGGCCAAC TACCAAAGCA 10140 CCCCGTCGAA CGACTGGCCG CCGTTCTTGG ACGACGTGCT CACCGCCGAT CCCGAAACCG 10200 TGCGGTACGA ATCGATCCTG TCCGAAGAAG GCGGTCGGTT CTACCAGGCG CAGAACAGGT 10260 ACCX3GATCAT G2AGGTGCAT GAGGACTTCG CGGCACXSACC TCCCAGCGAC TTCCGGTGGA 10320 TGACTTTGGG ACAGTTGGGC GAGCTGCTCC GGAGCACCCA CTTCTTGAAC ATCCAGGCGC 10380 GCAGCTTGGT CGCCTCCCTG CATAGCTTGT GGGCGTTGGG GCGATGACCA GCTCX5ATGCO 10440 AAAGCCGGTG CGCATCGGTC TGCTCGGGTG CGCTTCCTTC GCGTGGCGAC GGATGCTGCC 10500 CGCGATGTGC GACGTGGCCG AAACAGAGGT GGTGGCGGTG GCGAGCCGTG ATCCGGCGAA 10560 AGCCGAACGG TTCGCAGCGC GATTCGAATG CGAGGCGGTG CTGGGTTACC AGCGGCTCCT 10620 GGAGCGGCCG GACATCGATG CCGTCTACGT GCCGTTGCCO CCTGGGATGC ATGCAGAGTG 10680 GATCGGCAAG GCGCTTGAGG CAGACAAACA CX5TGCTTGCG GAGAAACCGC TGACGACGAC 10740 GGCGTCCGAC ACCGCTCGCC TGGTCGGGCT GGCCAGGAGG AAGAACCTGC TGCTGCX3GGA 10800 GAATTACCTG TTCCTCCACC ACGGCCGGCA CGACGTGGTC CGCGACCTGC TGCT^TCCGG 10860 GGAGATCGGT GAGCTCCGGG AGTTCACCGC CGTGTTCGGA ATTCCGCCGC TTCCCGACAC 10920 GGACATCCGC TATCGCACCG AACTCGGTGG CGGAGCGTTG CTGGACATCG GTGTCTATCC 10980 CGCCCOTGCC GCTCGGCACT ITCTCCTCGG TCCGCTCACX3 GTTCTCGGCG CAAGCTCGCA 11040 CGAGGCCCAG GAGTCGGGCG TCGACTTGTC GGGCAGCGTG CTGCTCCAAT CGGAAGGTGG 11100 CACCGTTGCC CACCTCGGAT ACGGT1TCGT GCACCACTAC CGCAGCGCGT ACGAGCTGTG 11160 GGGGAGTCGT GGGCGAATCG TCGTCGACCG GGCGTTCACG CCGCCCGCCG AGTGGCAGGC 11220 CGTGATCCGA ATCGAGCGGA AGGGCGTTGT CX3ACGAGTTG TCCTTGCCAG CGGAAGATCA 11280 GGTTCGCAAG GCGGTCACCG CCTTCGCACG CGACATCAGA GCAGGGACAG GCGTGGACGA 11340 CCCTGCGGTG GCCGGAGATT CGGGCX3AATC GATGATCCAG CAGGCCGCGC TGGTGGAGGC 11400 GATCGGTCAG GCCCGTCGGT GCGGGTCCAC ATAGCCGCCC GGCATCCGCG GGTAGTAGTT 11460 O^CTCGAAG CCTGACCGGG CATCCX3GAAG CCAGCGGGGA AGCCGCTGGA GAGGCTCACC 11520 GCCATCCGCT CACCTGGCAT CTCX5CX3GACC GCTGATCGCG GACGGCTCGG AGAAGTGCTC 11580 GTCGAACCAC GAGACGACCA CTCGCX5AGCT GGCCAGGGCG GCGGGAAAGT GAGCCAATCC 11640 GGAGAGCGGA TGCCACCGCA CTGGCGTACC CGCCGCGCGG TAGCTGTCCC GGAGTCGCTC 11700 GCCGAATGCG AACGGAACGA TCTCGTCGTC CGTGCTGTGG TAGACGAGCG TGGGGACCAC 11760 CGGGCCACCG TTCCTACCTG CGACGCTTTC GGCCAGTCGT GCGCGCCATC GAGGTTGCTC 11820 GAAAAGGCCG GAAGTGTCGA GGAAGTCGCT CAGCTCGCGG CCGAGGAAGC GGGTGACGAG 11880
71 1237058 六、申請專利範圍 CTCCGGTGCA CCGAGCTCGC GCACTTGATC AACGGCGGTA CGACCCGCTT CGGTGAGAAG CTCGTCX3AAT GGCAGATCGG GGTAGGCAGC GGCATGCCCG ACCAGGCCGG CCAGCACCGG CCCGGTGAAC ACCCCGTCAT TTCX3GTGGAT GATGTCCAGC AGATCGATCG GCACCGCACC TGCGGCCX3CA GCGCGGATTC GCAGTTCAGG TGCGTAGGTG GGGTGCAG1T CGCCGGCGAA GGCCGACGCT TGCCCACCCT GCGCATAGCC CCAGATGCCG ACCGGGCAGT CGGTCGTCAG GCCGGAGCCC GGTAGCCGTT GCGCAGCGCG GGCGGCATCG AGCATGGCGT GTCCCTGCGC CCTGCCGACO GTGTAGGTGT GGGTTCCAGG AGTACCGAGG CCTTCGTAGT CGGTGATGAC CACGGCCCAC CCGCGGTCGA GGGCCACGGC GATCAGCTCO GTCTCCGGCT CGGTTCCGGT TCGAAGCAGG TACGACGGGG CAACTTGGCT ACCGAGGCCG TGGGTGCCCA CTGCGAAAGT GATGATGGGG CX^TCITCGC GCGGCCACX3G GATGTTCGGC ACCAGAACX3G TGCCGGAGAC GGCGTTCGGC ATGCCAAGGG CGGAGTTGGA CCGGTAGAGG ATTTGCCAGG CCTTGGCTGC GACGGGTTCG CCCGTGCCGC GCAGTGCCGA GACGGGCCGG GCCCTGA.GGA GCGTGCCCX3G GACACCCGGC GGTAGCGGCG TCGGCGGTCG GTAGAAGGGA TCATCCGCGG GTGCCCGCAG ATCGTCGCCG ACGAGGCTGG CGTGCTCX3GA GGCCATCAGG ACIOCTTCTT TCGAGCCTGC AGGAGCATGA AACCCATGCT TTCCTCOTTT CTGGCOTAAT CQ3GATGTTT CCX3GTATTCC GCAACCGCGG CGATCAGCTG TGCTGGTCCC GGTCCGTGCT TCXSCCGCX5AT GTCTCCCAAG TAGCGTTGCT GGTAGGTGCC GACAGCCGCA GGCTCGACGC CGGCGAGCTC ATCX3AGTTTC CX3GAGCAACT CGTCGACGTA CCAGGAGACC ATGCACCTGG TCTGTGCCX3T GAGGTCGGTG ACTTCX^AGAA TCTCGAACCC GGCTTCGCTG ACCAGCGCCO TGAAGCTGTT CAAGGTATGG GCGGTCGTGC CCGTCCAAAC CGCCGCGTAC TCITCCGGGA GTCGAACCCG AGTGATGATG TCTCCGAGGA CGAACCGGCC GCCGGGTTCC AGGATTCGGT GGACCTCGCG GATCGCGGCG GCCTGGTCCA CGATCTGCAC GACGGACTGC ATCGCCCATG CGGCCTGAAA GAAACCGTCC GGGTAGGGCA GCTGGGCGCC GTCGACTAGA TCGAACTCAA GACTGCCX3GC CAGTCCGGTC TCGTTGGCGA GCCTGGTGGC GGCGGCGAGA TGCTGGGCGT TCACX3GTGAT TCCX3GTGACT CX3AACGCCGC TGGCGCATGC CGCACGGACT ACGGGCTGCC CATTGCCGCA GCCCAGGTCG AACAGGTGCG CTCCGGGACG GAGCGCGGCC TTGTCGATGA ACAGGTCGGT CAGTTGGTCG GCAGCATCCX3 ACCACGGTGT GGCACCGGCA TCCTCCCGAT ACCCX5CCCGC CCAGTAACCG TGGTGCAGGG GACGCCCGTG CGCCAACGCA TCGAAGATGG ACTCCACCTG ATCCGCGGTC GGAAATGCCT GTGTGTTCGC CCCTCTGCTG TTGACTCGTC CTCCGCGCTG TTCACGTCGG CCAGGTGCAA TATGTCGTCC AGACTCCTTG GCACCCAAGC AGGAACGCCG CCTTCGGCOT TGACGCCTTT CTCCAGGAAC GCGATGTTGT GGTAGGTGTG GAGGCCGACC AAATTGCGTT CCAGGTAGCT CGGCTCGTAC GAGCCCGCAT GCGGCTGCTC CTCGTGCTGA ACGCCTTCCA ACAGG1TCTT GAGCAGGCTG ACCGTGGTGC CGGGTGCGGC CGGGCACTGC GCCTGCCCGC CGAATCCX3GG AGCATAGGTC GTCCACAGAT CCTCGATCAC GTATACGCCA CCGCTGCGCA ACCX3GGGGAA CAGCGTTTCC AGGGATGTGC GCACGTGTCC GTTGATXSTGG CTGCCATCGT CGATGATGAT GTCX5AACGGT CCGTACITGT CGTCAACX3GC GGCCAGCTCC TCGGGCTTGC TCTGGTCGGC GCGGACGGTG CAGAGCCTCT GCTGGTCGAG GAAGGACTTG TCGAAAACGT CCATCCCGAA CACGAGGCCG CGGTGGAAGT AGCGCTTCCA CATCTTCAGG GATTCGCCGC CGCCACCGTC GAAGTTGTAG CCACCGACAC CGATCTCCAG GATGCGCACC GGGCGATCAC GGAACTCGCC GAGGTGTCGC TCGTATAGCG GGGTGAACCA GTGCAGGCCG CCCCACTTGT CCGTGCGGTA GTGGGAGGCG AGCAAGTTGA GGTCGGGACG TCGGTGCCCG CAGCCGGCGA 11940 12000 12060 12120 12180 12240 12300 12360 12420 12480 12540 12600 12660 12720 12780 12840 12900 12960 13020 13080 13140 13200 13260 13320 13380 13440 13500 13560 13620 13680 13740 13800 13860 13920 13980 14040 14100 14160 14220 14280 14340 1237058 六、申請專利範圍 CCACTGCGGA GATGGCCTGG AAGCCATCX3G ACAGTTCCGA CGGACCGGGT ATCGAACCGG 14400 ATGTGGTGGT TCGGAGGAAG TTGGTGCTCC GGGCX5CCGAC GGCCCTGGGA GCTCCTGGGC 14460 CX^AACAACTC GGCGATGAGA TCX3GTGAGCT COTAACCGAT CCGCAGCGGG ACGTCTCCGA 14520 CCGGTCGTTG CTCGGCCTTG ATCAGCTCAC CGGACTGTAG CGTCAGGACG AAGTGAACGG 14580 TCTCGCCTCG GTGGGTGATC TGGACCGCGA CCTCX3GTCCG TTCGATGTCG GGGGCCGGTT 14640 CCGCGCGGAA GAGGATCTCG TCGATCAGCA CGGGTGCGAT CCTGGCGAGT CCGAGTTCGG 14700 TGGTCAGGTC GGCCAGGCTC GCOGCACTGG ATCCGGCGGC GAGGATGATG CGTTCCACGG 14760 TTTCGATCTC GTGCOTTGTG GACATCGTGA TGAGCTCCTC ATGGCTGACC GGGTGAAAGC 14820 CGTGCCGGCG GTITGATCGA CAGGCCGTGC TGGAAGATGT TCTGCGGATC CCACCGCX3CT 14880 TTGGCCCGCT GCAGCCGCGG GTAGTTGTCT TTGTAGTACA GGTCGTGCCA GGCAACACCG 14940 GAGGTGTTCC ACAATGGATC GGCCAAGTCG GTGTCCGGGT AGTTGAIOTA GGAGCCGTCG 15000 ACACGGGTAC CTGGCACCGG AACTCCGCCG GTITCGGCGT ACATCTCGCG GTAGAAACCG 15060 CGAATCCAGG TCAGATGCCX5 CTCGTCCTCX3 GCGGGCTCCG ACCAGTTCGT GACGAACAGC 15120 GCTTTGAGAA CCGAGTCGCG CTGAGCJGAGT GCGGTGGCCG ACX3GAGCCAC GGCATTCGCC 15180 ATACCGCCGT AACCGAGCAG CAACAGCGCC GCCGCAGGGT TGTCOTATCC GTAGACGGTC 15240 AGCCGCCGGT AAACCGTGGC TAGTTGAGCT TCGGACAGCC CGGTGCGCAA GTAGGCGGCT 15300 TTOACCTTGG TCCGTTGCAT GCCCGGTTCG CCOCCTTCGG CGATCGCCCC GGCCACCTGG 15360 GTCGATCGCA ACCACGGCAG GGTTTCCCGC AGCCCTTCGG CTGGAGTCAC GCCGACCTGG 15420 GCGTTGATCG CCGACAGGTG TTCGGCCAGG GTGCG1TCC!G CGTTCX3GATC CGTGCCGTCC 15480 AGGTGAACGT TCAGCGTGAC GTAGCCAGCT TGCCX3GTGTG CGCAGACGAG COTGCTGAAC 15540 AACCCX3AGTT GCGTGGATTC AGGCX3CGCTG TGCTGCTCGT ACCAATTGCC GAAGTTCTGT 15600 AGGAGCACGG CGAATGACTG CTCTGTCAGT TCX5TGCCACG GCCAGTGGAA CGATCGGAGC 15660 AGCACTGTCG CGGGCX3GCCG TGGCAGGAGC TCTGCGGCGT CGGTGCTGAC CACGTCCGGC 15720 GTTCGGAGCC AAAACCTGGT GACX3ATCCCG AAGTTGCCGC CACCGCCACC GGTGTGCGCC 15780 CACCACAAGT CGTGACCGGC GCCCGTGGAG TTCCX3GTCGG CCTCGACGAT GTGCACTTCA 15840 CCX3GCCTGGT CGACCACX3AC GACCTCGACO CCTTGAAGGT AGTCGACGAC CGAACCGAAT 15900 CGGCGCGACA GCGGGCCGTA TCCCCCGCCG AGGATGTGCC CGCCTGCGCC CACCCCGGGA 15960 CATGCGCCGG TCGGGATCGT CACGCCCCAG TTCTTGAACA GGGTTCGGTA CACCTGCCCJG 16020 AGGGCX3GCGC CCGCCTCGAT CGCGAATGCC CCGCX3CGTGC TGTCGTAGTA CACX3CGGTTG 16080 AGCTCGGAGA GGTCGACGAG CACTCGGATC GCCGGGTCCG CAACX^AGATT CTCGAAGCAG 16140 TGCCCGCCGC TGCGGACCCC TACCCGCCTG CCGGTGCGCA CGGCGTCGGC GACX3GCGTGC 16200 ACGACGTCTT CGGCGGAGCT GGCGATGTGG ATGCGTTCGG GTTTTCCGGT GAAACGGGGG 16260 TTGTGCCCGA CGACGAGGTC CGGATAACGA GGATCGTCGG GCTCGACGGT GATCTCTGTT 16320 CCTGGGGTTC GACGATTCAT GGGTGCCGGG TCATGGAATT CGGGCACCGC CCCTCdTTT 16380 CTGACTGGTC (^CTTTGTTC GCCCX5CAGCC GAGATCATCT ACGCX3TCCGG GTGATTATCT 16440 GTGTGTTTCA GCTCATACGT GAAACCCGGT CX3CCTCCGCC GGCTCTACTT TGTGGATCGA 16500 TATCGCGGTG CGCATGGTGC CGTATGCGCT GGAACCGAAA AGGTGATGAC TTACCATGAG 16560 TGAGATCGCA GTTGCCCCCT GGTCGGTGGT GGAGCGTTTG CTGCTCGCGG CGGGTGCGGG 16620 CCCGGCGAAG CTCCAGGAAG CAGTGCAGGT GGCCGGACTG GACGCGGTGG CCGACGCCAT 16680 CGTCGACGAA CTCGTCGTAC GCTGCGATCC GCTGTCGTTG GACGAGTCGG TGCGAATCGG 16740 CCTGGAGATC ACTTCTGGCG CTCAGCTGGT CCGGAGAACC GTTGAGCTCG ATCACGCAGG 16800
1237058 六、申請專利範圍 CCTGCGGCTC GCGGCGGTCG CCGAAGCAGC TGCTGTTCTC CGGTTCGACG CGGTGGATCT 16860 GCTGGAAGGG CTCTTCX3GCC CGGTTGACGG CAGGCGGCAC AACAGCCX5TG AAGTCCGCTG 16920 GTCGGACAGC ATGACGCAGT TCTCGCCCGA CCAGGGCCTC GCCGGCGCGC AGCGCCTGCT 16980 GGCGTTCCGG AACAGGGTGT CCACCGCGGT GCACGCCGTG CTGGCCGCAG CCGCCACCAG 17040 GCGCGCGGAC CTCGGTGCX5C TGGCAGTCCG CTACGGATCC GACAAATGGG CGGACCTGCA 17100 CTGGTACACC GAACACTACG AGCACCACTT CTCCCGATTC CAGGATGCCC CGGTGCGAGT 17160 GTTGGAAATA GGAATCGGTG GTTATCACGC ACCCGAACTC GGTGGTGCTT CGCTGCGCAT 17220 GTGGCAGCGG TACTTCCGGC GAGGTCTCGT TTACGGGCTG GACATTTTCG AGAAAGCCX3G 17280 GAACGAAGGG CACCGAGTGC GAAAGCTGCG AGGTGACCAG AGCGATGCX3G AATTCCTGGA 17340 AGACATGGTG GCGAAGATCG GCCCGTTCGA CATTGTCATC GACGACGGCA GCCATGTCAA 17400 CGACCACGTC AAGAAATCCT TCCAATCCCT GTTTCCGCAC GTCCGCCCAG GTGGTITGTA 17460 CGTCATCGAG GATCTCCAGA CGGCGTACTG GCCCGGCTAC GGCGGTCGCG ATGGGGAACC 17520 CGCGGCCCAG CGCACCTCGA TCGACATGCT C7\AAGAACTG ATCX^ACGGCC TGCATTATCA 17580 GGAGCGCGAA TCGCGGTGCG GGACCGAGCC CTCCTACACG GAACGGAACG TGGCGGCCCT 17640 GCACTTCTAC CACAACCTGG TATTCGTGGA GAAAGGGCTC AACGCTGAGA CTGCCGCX3CC 17700 GGGGTTCGTG CCCCX3GCAAG CGCTCGGCGT CGAGGGCGGC TGAGCCGTTC ACCAGCTGCG 17760 GCGCCAGTAG GCGCCCGTGC CGTCGATGTC GTGGATGGGT TCCX3TGATCC CGAGTTCCGC 17820 GCGGAACCCC TTCACCGCGT CCTGGCAGGA CGGCAGAAAA TAGTCGTCX3A TGATGACGAA 17880 TCCGCCCX3GC GAGAGCTTCG GGTACAGGTT CCGCAATGAG TCCATTGTGG ATTCGTAGAG 17940 GTCGCCGTCG AGTCGTAGCA CGGCGAGTTC CTGGATGGGG GCGGTGGGCA AGGTGTCCCX3 18000 GAACCAGCCG GGGAGGAACC TGACCTGTTC GTCGAGCAGC CCX5TAGCGGG CGAAGTTCTG 18060 CCGGACX3GTC TCAAGCGATA CGCCAAGCAC GTCGTTGTAC TCGTGCAGCX3 CCATAGCCTG 18120 GTCCGCTTGG TGGTCTTGCG CAGAGCTITC CGGCATTCCC TGGAAGGAAT CCACTACCCA 18180 GACGGTACGT CCGGTATCTC CGAATGCCTG GAGAACCGCO CGCATGAAGA TGCATGCGCC 18240 GCCCCGCCAG ACACCGGTCT CGGCGAAATC CCCGGGAACA CCGTCTGCGA GCACGGCTTC 18300 CACGCAGTGC TGGAGGTTGT CCAGCCGCTC CAGACCGATC ATCX3TGTGCG CGACAGTTGG 18360 CCAGTCCGTG CCTTTGGCCC GAGCGGCCTG CCTGTAGTCG GTGTTGTCCT GCCAGGCGTT 18420 CX3GATGCGGC CGATCACTGT AAATCGTGTT GGTGAGTACC TTCTTGAGCA GGTCCAGGTA 18480 CAGCGCGTTC TGGGAGGGCA TCGGTTCTCC GGATCCAGCT GTTCTCX3GGT GACTAGTTCA 18540 TCAGGCACGG ATGGCCGCAG TGTTCTCCAG TGTCCGCACC AGCGCGGCGG GATGGGGCAT 18600 GGCCGTGATC TCGTCXOTGA GTTTGATTGC CGCAGAAGCG AAGCCGGTGT CGCCGAGCAC 18660 CGTTGCGATT GAGTCGGTGA ACTGTTCGTG GTCGGACTGG GCCTGCTCAT CCGGCAAGCA 18720 GATGCCCGCC CCGGCAGCGG CGAGGTTGCG CGCGTAGTCG AACTGGTCGA AGTACTGGGG 18780 AAGCACGAGT TGCGGGATGC CGAGTCGGGT CGCGGTGAAT GCCGTTCCCG AGCCX3CCCGC 18840 GCAGATGACC AGCTCGCAGG TACGCAGGAA CAGGTTGAGC GGGACCGATT CGGCGATCCG 18900 GGCGTTGTCG GGTAGGTCX3G TGAGAAGTGC CCGGTGCTCG GGGGGAACGG CGATCACGGC 18960 CTCGACX^CO GGCAACTCGG TGGCAGCCGC TACTGCGCGC AGCAGCGGAG CCGGCCCGGT 19020 GGCGTTCAGC ACCATGCGGC CCATGCAGAT GCAGACCCGC CGTGCTGAGG TGCGCGCCX3C 19080 GCCCCATGCC GGGAATGCGC CGCTTCCGTT GTACGGCACG TACTGGACCG GTGCGCCTTG 19140 CGGCGCGTCG CTIOCTTGCA GGCTCGGCGG ACAGGGATCG AGGATGAGCT CGGGAGTGGG 19200 CAGGCCGGTC AGTCCGTGGT GCCGGCACAC CGGGTCAAGC AACTCGTGGG CTCGATCGCT 19260
1237058 六、申請專利範圍 GAAGGGGCCT GCGGTGGGGT CGACTCCCCA GCGGTGCAGC ACGACCGGCA GGTCGAGCAA 19320 TCCGCCGAGC ACCCGGCCGA TCAGCGCGCA GACGTCGACC AACAGCACTG ACGGTCGCCA 19380 GGCCTCGGCC AGTCGAAGGT ATTCGGGGAG CTGATCGAGC GAGCTTTGCG CGACATTGGA 19440 CGCX3GTCTGC TCCCAGAGTT GCCGGCCTGC CTCGGTGTCG CGCTGACCGA ACGCCGGATT 19500 GGGAAAGCGC AGCTGCGTGG TTCCACCCGT ATCGCCGGTC CTGTCGTTCC CGCGGATCCC 19560 GGCCGTGGTG AGACCTGCAC CATGCGCGGT CGCCTGCAGC TCTGGTGGTG CGGCGATCAG 19620 GACCTCGTGC CCGGATGCTT GCAGCGCCCA GCACAGCGGC ACCATTGCCA TGAGATGCGT 19680 CGGATAGGGC AAGGGAACGA CGAGTACGCG CATACTTCGG ACCCCAGTCT CTTTCCCCCG 19740 ATTAGCGCAG CAGCCCCTAC TCCCATTGGC CAGGATTTGG AAAATGCGCT GCGTATGTCG 19800 ATCGCCGTTG ACGTCCAACG GACTTCCGGC GGCAACAATA GTGTGTCACG GCAGGAATGT 19860 CACGCGACCA TCGAAGATCT TTGGGTCGCC GCACCTGGTT TCACGCGAAC GAGTGAAATG 19920 CGCGAGCTCC GCTCGATCGG GGTGGGCCGG ACCTGTACGG imTCACCGT TGGTTCTGCG 19980 GGGATTCATG GGGAAGATTT GCGCTGGCTG TTTGCCTCCT GGCCGGATAG TTATAGTCX3G 20040 TACCGCCGCA TGCGGCGGTA ACCGCGAATT AACTGACGGC TAGTTTGCCG TCTTTTCTCT 20100 CTGTGTG1TT CCTGCTCGGT TCCAGAAAAT TACGAGAAGG TGAACGTTGC AGAGATCAGG 20160 CATACCGGTG TTGCCAGGTG GCGCACCAAC ATCGCAGCAG GTTGGGCAGA TGTATGACCT 20220 GGTCACGCCG TTGCTGAACT CGGTCGCGGG CX3GCCCCTGC GCCATCCACC ACGGCTACTG 20280 GGAGAACGAC GGGCGGGCTT CCTGGCAGCA GGCCGCCGAC CGGCTCACCG ACCTTGTCGC 20340 CGAACGGACC GTGCTCX^TG GCGGCGTTCG ACTGCTCGAT GTGGGGTGCG GTACCGGACA 20400 ACCAGCGCTG CGCGTCGCGC GCGACAACGC GATCCAGATC ACCGGCATCA CCGTCAGCCA 20460 GGTGCAAGTG GCCATCGCCG CTGATTGCXX： ACGCGAACGC GGACTAAGCC ACCX3GGTGGA 20520 CTTCTCOTGC GTCX3ATGCCA TGTCCCTGCC GTACCCGGAC AATGCTTTCG ACX3CCGCCTG 20580 GGCCATGCAG TCGCTGTTGG AGATGTCCGA ACC!GGACCGT GCCATCCGGG AAATCCTTCG 20640 AGTACTCAAA CCCGGTGGCA TCCTCGGCGT CACCGAGGTC GTCAAACGAG AAGCGGGCGG 20700 CGGGATGCCG GTGTCCX3GGG ACAGGTGGCC GACCJGGCCTT CGGATCTGCC TGGCTGAGCA 20760 ACTTCTGGAA TCOCTGCGTG CAGCGGGGTT CGAGATCCTC GATTGGGAGG ACGTGTCX3TC 20820 GAGGACCCGG TACTTCATGC CJGCAGTTCGC CX^AAGAGCTC GCTGCGCACC AGCACGGGAT 20880 CGCGGACAGG TACGGGCCGG CTGTCGCCGG CTGGGCCGCC GCGGTCTGCG ATTATGAGAA 20940 ATATGCCCAC GACATGGGCT ATGCGATTCT GACGGCGCGG AAGCCGGTCG GCTGAGGGCG 21000 CGCCGCAATT CGATGACGIT CATGCGCCGT GTCGGAGAAT CGCCGGTGGC GGCGCCAGCA 21060 QAGGCTGAAC TTACTGGTGG TGTGTCCAGG AATCX3GAGGG GCAGTACCX3A ATGAGCGAAG 21120 CCX3GGAACCT GATAGCCGTC ATCGGACTGT CCTGCCGCCT ACCCCAGGCG CCTGACCCX3G 21180 CTTCCTTCrG GCX3GTTGCTG CGCACCGGAA CGGACGCCAT CACCACGGTC CCX3GAAGGGC 21240 GGTGGGGCGA CCCGTTGCCT GGTCGGGATG CGCCCAAGGG CCCGGAATGG GGTGGTTTCC 21300 TGGCTGATGT CGACTGCTTC GATCCCGAGT TCTTCX3GGAT CTCGCCGCGA GAAGCGGCAA 21360 CCGTGGATCC CCAGCAGAGG CTGGCTCTGG AGCTCGCCTG GGAGGCACTC GAAGACGCCG 21420 GTATCCCCGC CGGCGAGCTG CGCGGTACTG CCGCCGGTGT GTTCATGGGG GCGATCTCTG 21480 ACGACTACGC CGCCCTGCTG CGCGAGAGCC CGCCGGAAGT GGCTGCGCAG TACCX3CCTCA 21540 CCGGCACCCA TCGAAGCCTG ATCGCCAACC GCGTGTCCTA TGTGCTCGGC CTGCGCGGGC 21600 CAAGCCTGAC GGTGGATTCA GGTCAGTCCT CGTCCCTGGT CGGCGTGCAT CTCGCCAGCG 21660 AGAGCCTGCG ACGGGGTGAG TGCACGATCG CACTCGCCGG CGGCGTGAAC CTCAACCTGG 21720
75 1237058 六、申請專利範圍 CCGCCGAGAG CAACAGCGCT CTGATGGACT TCGGCGCGCT CTCCCCGGAC GGTCGCTGCT 21780 TCACCTTCGA TGTGCX3GGCG AACGGTTACG TCCGTGGTGA GGGCGGCGGC CTTGTCGTGC 21840 TGAAGAAGGC CGATCAGGCG CACGCCGATG GCXSACCGGAT CTACTGCCTC ATCCGCGGCA 21900 GCGCGGTCAA CAACGATGGG GGCGGTGCCX5 GGCTCACCGT TCCGGCX3GCG GACGCCCAGG 21960 COGAGCTGCT GCGCCAGGCA TACCGGAACG CGGGCGTCGA CCCGGCCGCC GTGCAGTATG 22020 TCGAGCTCCA CGGCAGCGCG ACCAGGGTCG GGGATCCCGT CXSAAGCAGCA GCCCTCX3GAG 22080 CTGTCCTGGG GGCGGCGAGh CGGCCCGGCG ACGAGCTGCG TGTGGGGTCG GCGAAGACCA 22140 ACGTCGGCCA TCTGGAAGCA GCGGCGGGCG TCACCGGGTT GCTGAAGACC GCACTCAGCA 22200 TCTGGCACCG CGAACTGCCG CCGAGTCTTC ATTTCACCGC CCCCAACCCG GAAATCCCGC 22260 TGGACGAATT GAACCTACGC GTCCAGCGTG ATCTGCGGCC GTGGCCGGAG AGCGAGGGGC 22320 CGCTGCTGGC CGGCGTCAGC GCCTTCGGAA TGGGAGGCAC GAACTGCCAC CTGGTGCTCT 22380 CCGGCACGTC CCGGGTGGAG CGACGGCGCA GTGGACCCGC TGAGGCGACC ATGCCGTGGG 22440 TCTTGTCGGC CAGAACACCG GTCGCATTGC GTGCGCAGGC GGCGCGCTTG CACACX5CACC 22500 TCAATACGGC CGGTCAAAGT CCGTTGGACG TCGCCTACTC ACTGGCGACC ACTCGATCCG 22560 CGCTACCGCA CCGGGCCGCG CTGGTCGCGG ACX3ACX3AACC GAAACTGCTC GCCX3GGTTGA 22620 AGGCCCTCGC TGACGGCGAC GACGCGCCCA CGCTGTGCCA CGGCGCGACT TCCX3GCGAGC 22680 GGGCAGCGGT CTTCGTCTTT CCCX3GACAGG GCAGCCAGTG GATCGGGAIO GGTAGGCAGC 22740 TGCTCGAAAC CTCCGAGGTT TTCGCGGCGT CGATGTCGGA CTGCGCCGAC GCATTGGCGC 22800 CACACCTGGA TTGGTCCCTG CTGGATGTGC TGCGCAACGC GGCCGGCGCT GCGCACCTTG 22860 ACCACGACGh TGTCX3TCCAG CCCGCGCTGT TCGCCATCAT GGTCTCGCTC GCGGAGCTCT 22920 GGCGTTCGTG GGGCGTGCGT CCGGTGGCGG TCGTCX3GGCA CTCGCAGGGG GAGATCGCJGG 22980 CGGCCTGCGT CGCCGGGGCC CTGTCCGTCC GCGATGCCGC CAGGGTGGTG GCX3GTGCX3CA 23040 GCAGGCTTCT GACX3GCGCTG GCCGGCAGTG GCGCGATGGC CTCGTTGCAG CATCCCX3CCG 23100 AAGAGGTGCG GCAAATCCTG TTGCCCTGGC GCGATCGGAT CGGCGTGGCG GGGGTGAACO 23160 GhCCGTCGTC GACCCTGGTG TCAGGGGACC GGGAGGCJGAT GGCGGAACTG CTGGCCGAGT 23220 GCGCAGACCG AGAGCTCCGG ATGCGCCX3GA TTCCCGTTGA ATACX5CCTCC CATTC!GCCTC 23280 ACATCGAGGT TGTCCGGGAT GAGCTGCTGG GGCTGTTGGC GCCGGTCGAA CCCAGGACGG 23340 GAAGCATCCC GATCTATTCG ACGACGACCG GGGACCTGCT GGACCGGCCG ATGGACX3CCO 23400 ACTACTGGTA C(^CAACCTT CGTCAACCGG TGCTGTTCGA AGCGGCCGTC GAGGCCCTGT 23460 TGAAGCGGGG GTACGACGCA TTCATCX3AGA TCAGCCCACA CCCGGTGCTG ACTGCGAACA 23520 TCCAGGAAAC CGCCGTGCGA GCAGGGCGGG AGGTAGTGGC GCTCGGGACA CTCCGCCGCG 23580 GCGAAGGTGG CATGCGGCAG GCGCTGACGT CGCTGGCCAG AGCACACGTA CACGGAGTGG 23640 CCX3CGGACTG GCACX3CGGTC TTCGCCGGTA CCX3GGGCGCA GCGGGTCGAC CTGCCGACGT 23700 ACGCCTTTCA GCmCAGCGC TACTGGCTGG ACGCGAAGCT TCCCGACGTC GCCATGCCCG 23760 AGAGCGACGT GTCGACGGCG TTGCGGGAAA AGCTGCGGTC TTCGCCGAGG GCGGACGTGG 23820 ACTCGhCGhC CCTCACGATG ATCCGGGCAC AGGCAGCCGT GGTCCTCGGC CACTCCGATC 23880 CGAAAGAGGT GGACCCGGAT CGGACGTTCA AGGACCTGGG CTTCGATTCC TCGATGGTGG 23940 TCGAGCTGTG CGACCGCCTA AACGCCGCCA CAGGTCTGCG ACTCGCACCG AGCGTCGTTT 24000 TCGACTGTCC TACGCCGGAC AAGCTCGCCC GCCAGGTACO GACGTTGTTG TTGGGCGAGC 24060 CGGCTCCCAT GACGTCACAC CGGCCGGACT CCGATGCGGA CX^AGCCTATC GCCGTGATCG 24120 GGATGGGCTG TCGGTTTCCO GGTGGGGTGT CCTCGCCCGA GGAGTTGTGG CAGTTGGTCG 24180
76 1237058 六、申請專利範圍 CCGCTGGGCG GGACGTCGTG TCCGAGTTCC CGGCTGACCG AGGTTGGGAC CTGGAGCGTG 24240 CGGGGACATC GCACX3TGCGC GCCGGCGGGT TCITGCATGG CGCCCCGGAT TTTGACCCCG 24300 GGTTCTTCCG GhTYTCGCCG G3CGAGGCGT TGGCX5ATGGA TCGACAGCAG CGGTTGCTGC 24360 TGGAAATCX3C CTGGGAAGCA GTCX3AACGAG GCX3GGATCAA CCCGCAGCAC CTGCACGGAA 24420 GTCAAACCGG GGTCTTCGTC GGCGCGACCT CCCTGGACTA CGGGCCACGC CTGCACJGAAG 24480 CX5TCCGAGGA GGCGGCCX3GG TACGTGCTCA COGGCAGCAC CACX5AGTGTG GCGTCGGGTC 24540 GGGTTGCGTA TTCGTTCGGG ITCGAGGGCC CTGCX3GTGAC GGTGGATACG GCGTGTTCGT 24600 CGTCGTTGGT GGCCCTGCAT TTGGCGTGTC AGTCG1TGCX3 TTCGGGTGAG TGTGATCTGG 24660 CGTTGGCCX3G TGGTGTGACC GTGATGGCCA CGCCGGGGAT GTTCGTGGAG TTTTCX3CX3GC 24720 AGCGTGGTTT GGCGCCGGAT GGGCGGTGCA AGTCGTTCGC GGAGGCCXX：C GACX^GCACCG 24780 GCTGGTCCGA GGGTGCTGGC CTGGTTCTAC TGGAGCGGTT GTCGGATGCC CGGCGGAATG 24840 GGCATGAGGT GCTGGCGGTT GTTCGTGGTA GTGCGGTGAA TCAGGACGGT GCGTCGAATG 24900 GTTTGACCGC GCCGAATGGT TCOTCX3CAGC AGCGGGTGAT TGCCCAGGCA TTGGCGAGTG 24960 CGGGGTTGTC GGTGTCCGAT GTGGATGCTG TGGAGGCGCA TGGGACGGGC ACm^GCTTG 25020 GTGATCCGAT CGAGGCGCAG GCGCTGATCG CCACCTACGG CCAGGGCCGG CTTCCGGAAC 25080 GGCCATTGTG GTTGGGCTCG ATGAAGTCGA ACATCGGTCA CGCGCAGGCA GCTGCGGGGA 25140 TAGCCGGCGT CATGAAGAIO GTGATGGCGA TGCX3GCACGG GCAGCTACCX5 CGCACGTTGC 25200 ACX3TGGATGA GCCGACTTCT GGGGTGGATT GGTCGGCGGG GACGGTTCAA CTCCITACGG 25260 AGAACACGCC CTGGCCCGGG AGTGGTCGTG TTCGTCGGGT GGGGGTGTCG TCGTTCGGGA 25320 TCAGTGGTAC TAACGCGCAC GTCATCCTCO AACAGCCCCC GGGAGTGCCG AGTCAGTCTG 25380 CGGGGCCGGG TTCGGGCTCT GTCGTGGATG TTCCGGTGGT GCCGTGGATG GTGTCX3GGCA 25440 AAACACCCGA AGCGCTATCC GCGCAGGCAA CGGCGTTGAT GACCTATCTG GACGAGCGAC 25500 CTGATGTCTC CTCGCTGGAT GTTGGGTACT CGCTGGCGTT GACACGGTCG GCGCTGGATG 25560 AGCGAGCGGT GGTGCTGGGG TCGGACCGTG AAACGITGTT GTGCGGTGTG AAAGCGCTGT 25620 CTGCCGGTCA TGAGGCTTCT GGGTTGGTGA CCGGATCTGT GGGGGCTGGG GGCCGCATCG 25680 GGTTTGTGTT TTCCGGTCAG GGTGGTCAGT GGCTGGGGAT GGGCCGGGGG CTITACCGGG 25740 CTTITCCGGT GTTCGCTGCT GCCTTTGACG AAGCTTGTGC CGAGCTGGAT GCGCATCTGG 25800 GCCAGGAAAT CGGGGTTCGG GAGGTGGTGT CCGGTTCGGA TGCGCAGTTG CTGGATCGGA 25860 CGTTGTGGGC GCAGTCGGGT TTGTTCGCGT TGCAGGTGGG CTIOCTGAAG TTGCTGGATT 25920 CGTGGGGGGT TCGGCCGAGT GTGGTGTTGG GGCATTCGGT GGGCGAGTTG GCGGCGGCGT 25980 TCGCGGCGGG TGTGGTGTCG TTGTCGGGTG CGGCTCGGTT GGTGGCGGGT CGTGCCCGGT 26040 TGATGCAGGC GTTGCCGTCT GGCGGTGGGA TCCTGGCGGT GCCTGCTGGT GAGGAGCTGT 26100 TGTGGTCGTT GTTGGCCGAT CAGGGTGATC GTGTGGGGAT CGCCGCGGTC AA05CTGCGG 26160 GGTCGGTGGT GCTCTCTGGT GATCGGGATG TGCTCGATGA CCTTGCCGGT CGGCTGGACG 26220 GGCAAGGGAT CCGGTCGAGG TGGTTGCX^3G TGTCGCATGC GTTTCATTCG TATCGGATGG 26280 ATCCGATGCT GGCGGAGTTC GCCGAATTGG CACGAACCGT GGATTACCGG CGTTGTGAAG 26340 TGCCGATCGT GTCX^ACCTTG ACCGGAGACC TCGATGACGC TGGCAGGATG AGCGGGCCCG 26400 ACTACTGGGT GCGTCAGGTG CGAGAGCCX3G TCCGCTTCGC CGACX3GTGTC CAGGCX3CTGG 26460 TCGAGCACGA TGTGGCCACC GTTGTCGAGC TCGGTCCGGA CGGGGCGTTG TCX3GCGCTGA 26520 TCCAGGAATG TGTCGCCGCA TCCGATCACG CCGGGCGGCT GAGCGCGGTC CCGGCGATGC 26580 GCAGGAACCA GGACGAGGCG CAGAAGGIX^A TGACGGCCCT GGCACACGTC CACGTACGTG 26640
77 1237058 六、申請專利範圍 GTGGTGCGGT GGACTGGCGG TCX^TTCTTCG CCGGTACAAG GGCGAAGCAA ATCGAGCTGC 26700 CCACCTACGC CTTCCAACGA CAGCGGTACT GGCTGAACGC GCTGCGTGAA TCTTCCGCCG 26760 GCGACATGGG CAGGCGTGTC GAAGCGAAGT TCTGGGGCGC CGTCGAGCAC GAAGATGTGG 26820 AATCGCTTGC ACGCGTATTG GGCATTGTGG ACGACGGCGC TGCTGTGGAT TCCCTGAGAA 26880 GCGCCCTTCC GGTGTTGGCC GGTTGGCAGC GAACCCGCAC CACCGAGTCC ATTATGGATC 26940 AGCGGTGTTA CCGAATTGGC TGGCGGCAGG TAGCCGGACT CCCGCCGATG GGAACTGTTT 27000 TCX^GTACCTG GCTGGTCTTC GCGCCTCATG GCTGGTCCAG CGAACCGGAG GTGGTGGACT 27060 GCGTTACGGC ACTGCGGGCA CGTGGTGCCT CGGTGGTGTT GGTGGAAGCT GATCCCGACC 27120 CGACCTCCTT CGGCGACCGG GTACGAACCC TGTGTTCGGG CCTTCCX^GAT CITCTTGGCG 27180 TGTTGTCAAT GTTGIXXTTG GAAGAATCGG TCCTTCCGGG ATITTCTGCG GTGTCACX3GG 27240 GTTTTGCGTT GACCGTGGAG TTGGTGCGGG TITTGCGGGC AGCTGGTGCG ACTGCCCGGT 27300 TGTGGTTGCT GACGTGTGGT GGCGTGTCGG TGGGAGATGT ACCX3GTTCGT CCAGCX5CAGG 27360 CCCTGGCGTG GGGGTTGGGG CGTGTTGTGG GGTTGGAGCA TCCGGACTGG TGGGGCGGCT 27420 TGATCGATAT TCCX3GTCTTG TTCGACGAAG ACGCTCAAGA GCGGTTGTCG ATTGTGCTGG 27480 CAGGTCTCGA TGAGGACGAG GTCGCX3ATCC GTCCTGACGG CATGTTCGCG CGTCX3GTTGG 27540 TACGCCACAC TGTCTCAGCT GATGTGAAGA AGGCGTGGCG CCCCAGGGGA TCGGTGCTGG 27600 TGACGGGCGG CACGGGTGGT TTGGGGGCGC ACGTTGCTCG CTGGCTGGCC GACGCCGGAG 27660 CCGAACAIOT GGCGATGGTG AGTCGACGCG GCGAGCAGGC ACCGAGTGCT GAGAAGTTGC 27720 GGACGGAACT GGAGGATCTG GGTACCCGGG TGTCGATCGT GTCATGCGAT GTGACCGATC 27780 GCGAGGCX5CT CGCCGAAGTG CTGAAAGCCC TTCCGGCTGA AAACCCG1TG ACCGCGGTAG 27840 TGCATGCGGC AGGCGTGATC GAGACTGGTG ATGCGGCGGC AAIXSAGCCIG GCTGATITCG 27900 ATCACGTGTT GTCCGCAAAG GTGGCCGGTG CCXK：GAATCT GGATGCCTTG TTGGCCGATG 27960 TGGAATTGGA CX3CGTTCGTC TTGTTCTCAT CGGTGTCAGG AGTTTGGGGC GCTGGGGGAC 28020 ACGGGGCTTA CGCAGCGGCG AATGCCTATC TGGATGCGCT CGCGGAACAG CGTCX3GTCX5C 28080 GAGGGCTGGT CGCGACTGCG GTGGCCTGGG GGCCGTGGGC CGGCX5AGGGC ATGGCCTCCG 28140 GAGAAACAGG AGACCAGCTG CGCCGATACG GCCTTTCCCC AATGGCTCCG CAGCACXXICA 28200 TCGCCGGAAT CCGGCAGGCC GTGGAACAGG ACGAAATTTC CCTGGTAGTG GCCGATGTCX3 28260 ATTGGGCACG TTTCAGCGCG GGATTGCTGG CGGCTAGGCC GCGGCCGCTG CTGAACGAAC 28320 TGGCCGAGGT CAAGGAACTC CTCGTCGATG CCCAGCCCGA GGCGGGAGTC CTTGCCGACG 28380 CGTCGTTGGA ATGGCGGCAG CGA1TGTCCG CGGCACCGAG GCCGACACAG GAACAGCTGA 28440 TCCTGGAGCT GGTACGCGGC GAAACCGCTC TGGTGCTGGG ACACCCCGGG GCAGCGGCCG 28500 TTGCATCGGA ACGAGCCTTC AAGGACAGCG GATTCGACTC GCAGGCCGCG GTCGAACTCC 28560 GCGTTCGGCT CAATCGAGCT ACCGGCCTCC AGTTGCCATC GACAATTATC TTCAGCCATC 28620 CCACGCCTGC GG^CTGGCT GCGGAGCTGC GGGCGAGGCT TCTTCCCGAG TCCGCAGGAG 28680 CAGGCATTCC CGAGGAGGAC GAGGCGCGAA TCAGAGCGGC ACTGACGTCG ATCCCGTTCC 28740 CGGCCTTGCG CGAGGCAGGC TTGGTGAGTC CGCTGCTCGC ACTTGCCGGA CACCCGGTCG 28800 ACTCCGGTAT CTCCTCGGAC GATGCGGCCG CGACCTCGAT CGATGCGATG GATGTAGCCG 28860 GCCTCGTCGA AGCAGCGCTG GGCXSAACGCG AGTCCTGAGA CCGCCGACCT GGGAGATGAC 28920 GGTGACCACC AGTTACGAAG AAGTTGTCGA GGCACTGCGA GCATCGCTCA AGGAGAACGA 28980 ACGCCTCCGG CGCGGCAGGG ATCGGTTCTC CGCGGAGAAG GACGATCCCA TCGCGATCGT 29040 GGCGATGAGT TGTCGTTATC CCGGTCAGGT CTCCTCGCCG GAGGACCTGT GGCAACTGGC 29100
7 8 1237058 六、申請專利範圍 TGCCGGCGGT GTGGACGCGA TCTCCGAAGT TCCGGGGGAT CGCGGATGGG ACCTGGATGG 29160 CGTGTTCGTT CCGGACTCCG ATCGTCCTGG CACGTCGTAT GCCTGCGCGG GCGGTTTTCT 29220 TCAGGGCGTG TCGGAGTTCG ACGCGGGTTT CTTCGGGATT TCGCCGCGTG AGGCGCTGGC 29280 GATGGATCCG CAGCAGCGGT TGCTCCTGGA AGTCGCGTGG GAGGTCTTCG AGCGGGCTGG 29340 GCTGGAGCAG CGGTCGACAC GCGGTTCCCG CGTTGGCGTG TTCGTCGGCA CCAATGGCCA 29400 GGACTACGCG TCGTGGTTGC GGACGCCGCC GCCTGCGGTG GCAGGTCATG TGCTGACGGG 29460 CGGTGCGGCA GCGGTTCTTT CGGGCCGGGT TGCGTATTCG 1TCGGGTTCG AGGGTCCTGC 29520 GGTGACGGTG GATACGGCGT GTTCGTCGTC GTTGGTGGCG TTGCACCTGG CGGGGCAAGC 29580 ACTGCGGGCC GGTGAGTGCG ACCTTGCCCT TGCCGGTGGC GTCACGGTGA TGTCGACGCC 29640 GAAGGTGTTC CTGGAGTTCT CCCGCCAACG GGGTCTCGCG CCGGATGGGC GGTGCAAGTC 29700 GTTCGCGGCG GGTGCGGATG GCACTGGATG GGGTGAGGGT GCCGGACTGT TGTTGCTGGA 29760 GCGGTTGTCG GATGCCCGGC GGAATGGGCA TGAGGTGCTG GCGGTTGTTC GTGGTAGTGC 29820 GGTGAATCAG GACGGTGCGT CGAATGGTTT GACCGCGCCG AATGGTTCGT CGCAGCAGCG 29880 GGTGATTACC CAGGCGTTGG CGAGTGCGGG GTTGTCGGTG TCCGATGTGG ATGCTGTGGA 29940 GGCGCATGGG ACGGGCACGC GGCTTGGTGA TCCGATCGAG GCGCAGGCGC TGATCGCCAC 30000 CTACGGCCGT GATCGTGATC CTGGCCGGCC GTTGTGGTTG GGGTCGGTCA AGTCGAACAT 30060 CGGTCATACG CAAGCGGCGG CGGGTGTGGC TGGTGTGATC AAGATGGTGA TGGCGATGCG 30120 GCACGGGCAG CTGCCACGCA CGTTGCACGT GGAATCGCCG TCGCCGGAGG TGGATTGGTC 30180 GGCGGGGACG GTTCAACTCC TTACGGAGAA CACGCCCTGG CCCAGGAGTG GTCGTGTTCG 30240 TCGGGTGGGG GTGTCGTCGT TCGGGATCAG TGGTACTAAC GCGCACGTCA TCCTCGAACA 30300 GCCCCCGGGA GTGCCGAGTC AGTCTGCGGG GCCGGGTTCG GGTTCTGTCG TGGATGTTCC 30360 GGTGGTGCCG TGGATGGTGT CGGGCAAAAC ACCCGAAGCG CTATCCGCGC AGGCAACGGC 30420 GTTGATGACC TATCTGGACG AGCGACCTGA TGTCTCCTCG CTGGATGTTG GGTACTCGCT 30480 GGCGTTGACA CGGTCGGCGC TGGATGAGCG AGCGGTGGTG CTGGGGTCGG ACCGTGAAAC 30540 GTTGTTGTGC GGTGTGAAAG CGCTGTCTGC CGGTCATGAG GCTTCTGGGT TGGTGACCGG 30600 ATCTGTGGGG GCTGGGGGCC GCATCGGGTT TGTGTTTTCC GGTCAGGGTG GTCAGTGGCT 30660 GGGGATGGGC CGGGGGdTT ACCGGGCTTT TCCGGTGTTC GCTGCTGCCT TTGACGAAGC 30720 TTGTGCCGAG CTGGATGCAC ATCTGGGCCA GGAAATCGGG GTTCGGGAGG TGGTGTCCGG 30780 TTCGGATGCG CAGTTGCTGG ATCGGACGTT GTGGGCGCA.G TCGGGTTTGT TCGCGTTGCA 30840 GGTGGGCTTG CTGAAGTTGC TGGATTCGTG GGGGGTTCGG CCGAGTGTGG TGTTGGGGCA 30900 TTCGGTGGGC GAGTTGGCGG CGGCGTTCGC GGCGGGTGTG GTGTCGTTGT CGGGTGCGGC 30960 TCGGTTGGTG GCGGGTCGTG CCCGGTTGAT GCAGGCGTTG CCGTCTGGCG GTGGGATGCT 31020 GGCGGTGCCT GCTGGTGAGG AGCTGTTGTG GTCGTTGTTG GCCGATCAGG GTGATCGTGT 31080 GGGGATCGCC GCGGTCAACG CTGCGGGGTC GGTGGTGCTC TCTGGTGATC GGGATGTGCT 31140 CGATGACCTT GCCGGTCGGC TGGACGGGCA AGGGATCCGG TCGAGGTGGT TGCGGGTGTC 31200 GCATGCGTTT CATTCGTATC GGATGGATCC GATGCTGGCG GAGTTCGCCX3 AATTGGCACG 31260 AACCGTGGAT TACCGGCGTT GTGAAGTGCC GATCGTGTCG ACCTTGACCG GAGACCTCGA 31320 TGACGCTGGC AGGATGAGCG GGCCCGACTA CTGGGTGCGT CAGGTGCGAG AGCCGGTCCG 31380 CTTCGCCGAC GGTGTCCAGG CGCTGGTCGA GCACGATGTG GCCACTGTTG TCGAGCTCGG 31440 TCCGGACGGG GCGTTGTCGG CGCTGATCCA GGAATGTGTC GCCGCATCCG ATCACGCCGG 31500 GCGGCTGAGC GCGGTCCCGG CGATGCGCAG GAACCAGGAC GAGGCGCAGA AGGTGATGAC 31560 Ί9
1237058 申請專利範圍 GGCCCTGGCA TACGGGAGCG GGTGCCATCG GTTGGGTGCT GGTGCGGACG CACCGCGTTG AGAGCTCACC GCGAGTGGGC AGGGGCGGCG CGAGGCGGCT CGAATTCTAT CAAGGCGGCC AGATTCTGGT CCGAGACATG GGCCGCGCCG 3TGAT :CCGG CTGGCCAACG CTCAGAAGTG GGATGCCGGT AACAGCGGAT CGATCAGCGA GCCGGGCGAA GCAGACCGAA CCCCGCGCTG CGCTCATGCG CACCGGGTGG CGAACCGACG CGGGGTGAAC GGGCAGTGAG CGGCGACCGC TCGCATGGTG COTCTTTCTC GTTGCTGGTT CCTCGGTGCA CCGAGAACAC CGGCGGACGC TCTGCGAATG CCCCGTCGAG GGCAGGCCCG CGTGCTGGAG CACGTCCACG AAACAAATCG GATTCCGGTG GTGGTGCCGG CATCCGTGGC CTGGAGATCG CTGGAAGCAC GCGCCCGAGA GAGCATGACT GGAGACCTGG CGGGACCTCG TGGCGGCAAG TTCGGGGTGC GATGACGCAC GCTITGCGGG GGCACCGGTC CGGACCGGTG GTTCAACTGC TCCGCTGACA GCCGAACCAC GTCCGGGAGA CTCAACGAAT CCCGTGACCG CACCCTGA.TC CCGGGGGTGC CCCAGACTGG CGATTGGAGG GCCACGGCAC TTCCGGGATG GGCGCCGGGG GTGATGGGAA ACGAGGATTC ACCGCCTACT CATTCGGCCG GAGGTGTACX3 CTCGCTTCGT GGCGTCGACG CTGCCGCGCG GTCGCCGATG CAGCGAATCG CCCCTGCCTG TACGTGGTGG AGCTGCCCAC ATGTGACAGG TCGCGGGTGG TGGCCGAACA CCTTGCACGC CGCTGGTCCT ATTCCGGACG GGACGCGGCA CCGACTGGCC CAGAGCTTGG GGGACGAGGT ATCCGGCACT GCTTGCCGTT TCCGCGTGGT GACCGGTGAT CGCGCCGACA CGACATCCGC TACAGGTGTA CCGGCGTCGT CGACTCGGCA CCCGATTGCT ATCTGGCGCA GCTTCGTCCT TGGCCTGCGG CTGGACTGGG CCACGCGCCC CGCTGGGTGA CGCTCATCGC TCGTGGTGGA TGATCCCGAA CCGCTGGTTG ACGCGCTGGT CCGGTGGGGT CCACCGCTAG CGCGGACGTG TCGTGCTCAA GTGGCCGTTT CGCATCCGGG GCGAGATGCT TCACGGCTTG TGCGGTGGAC CTACGCCTTC TGCCGGTCTG TGACGAGGTG CCGGGTGCTG GGGGGAACGT GCCGGAGCGC CAGGCCGATG CGCCACGGGC GGCTCCTGGC GCTGGAGTAC GTACGCCGAA GCTGGACGCG CCAGTGGGAA CCCGGCTGGT CTCGGTGGAC GGCCCATCAA TCAGCCACCG TCCGGACCTC CATCGCACCC TGCACTCGAC CCTGGTGACA GGCCGCGCTC CGTCGATGTG CGAACCTCAG CA.GCGATGAC GGGAAGCCTG CGGTGAGGTC GCTCGGTATG GACCGGCCCC GGCGTTCGGG GAGCTTCGCG TGATCTCGCC GGGGATGGCC CGAGGACAAG CGATTTCGAG CTCCCTCGCC CCTGGAGTTG CGTGTCTTAC TCACGAGCTG GGACGTTCGG TGGCGGTCGT CAACGACAGC GCCGGGGCGG TTGCTGACCG GGTGAAGTGA CTTGGTTGTG GGGGCGATCC GCGCTGTATT CGGTTGGCGC GCGCTGCCGG GGCCCGATCT GCCGCGCTGC GCTCTGCACG GGTGTGTCCC GACGATGCCA CGACTCGTAT GCTCGGTTGT TCCTGCGTGC CGGTCGTTGA ACGCCCCCCG CTGGTACAAG CAGGGAGCAG TGGGGACTGC CCTGAGCCCG CTCGCGTTGC GTCCTGCCCG GATGGGTTGG AGGA1： TATCCCGGTG GGCGTCACCG CCGCTCGCGG CGGGCCGCAT GGGTTGAGAC GCGATCCAAC TGGCAAGCCG CAGCAGTTCC GGGGAGTTCG GGGAAGACGG CAGGCTTTCG GTGGAGTTGT CAGGCGCCCG TCTTCGCCGG GGTACTGGCT AGCATCCGCT GCAGGATTTC TCGTTGCGGG AACGGGTGGA AGGTTCAGCT CACGCCCCGA CAGGCCGCGG TCGACCTCGA TCCAAGGGCT CGGGAACGGA CAACGGCTGT TGCACGCCAA AGTCCCTGCT TGCGGTCGGC ACCGGTTGAG TTCTCGGCAC CGGCTGCGTT GCGGTGGACG GCTGGCTTTC TGGCCGTGGA TGCGGTCGAC CGCAACTCCT GACGTGGCGG TGCCGGACGG CAITGGTGGA TGCGCGCGGC TGGCATCGCT GCCTGGCACC TCGCCGACCA CGGTGCCGAT CAGGGGAGTC TCGCCAGGCA TGGAGCTGAG TCGGGGCAAC CCGATGCGTC ATGTTCGTGA ATACCGTAGA TCGAGGGACG AGGCGCTACG 31620 31680 31740 31800 31860 31920 31980 32040 32100 32160 32220 32280 32340 32400 32460 32520 32580 32640 32700 32760 32820 32880 32940 33000 33060 33120 33180 33240 33300 33360 33420 33480 33540 33600 33660 33720 33780 33840 33900 33960 34020 80 - 1237058 申請專利範圍 GCACCTGAGC CGCCGCAGGC GCACCTCGTG AGCCAGTGGC GCAGGCTTGC CGAGCATCCG ATCGCTCACC TCTGCTCGAG GCTCGGCAGC GCAGCAAAGG ACATGGCATG GCTGCCGATC TACCGTGGTG CGTCCTGCAA CGAGhGCCTC GGACCTCGTC CGCGGhCGGC CCGGATCAAC GCCGGATGCG ATTCGAGGAA GCGGGCGCAG CGGAACCGGC CCAACTCCTC CCTGGAGGGA CTCGTGGATC CCCATCGCGA CTGTGGAAAC TGGCACCTCG CACGGCGGCT CGTGAGGCGC GTCGAATCCG GGAITGATGT TATCTCGGAA TTCGAGGGCC TTGGCGTGTC GTGATGTCGA GGGCGGTGTA TTGGTGTTGC GTTCGTGGTA CTGGCCCAGG GTGGACGCTG CAAGCGCGGC ACGGTTCTGG ATCGAGCGCG GCTGCTGAGC GATGTCGCCG TTGACCGCCG GTGGAGCGGC CTGATCGACC GGTGGGCAGG CAGTCGCGCG GCCAGCACCT TCGACCGAGG CGGAAACGGT CGCATGCATG ACGTTCAAGG GGGGCGACGG CTCGCCGCGC CTCGACAGGT ATCACCACCC GGCGGCTCCG GACAACGATC AACGCCACAT TGCACCAGGC TCGTGGCGAT TGGTCGCCTC ACGAGCTCTA TCCTCCACGA TCGCGATGGA CTGGGATGGA ACGAGGGCTA CCGGCAATGC CAGCGGTGAC AGTCGTTGCG CGCCGGAGAG AGTCGTTCGC TGGAGCGGCT ATGTGGGAAA TTACCGGCGG GGGTGCGAAA TCGTGGCGCA ATCGTGAGAC TGGTGCACGC TGGACCAGGT CGGACGTGGC GTAACTACGC GCCTACCGAC TGCGCGAAGC AGGGGTTGTC GATTCAGCCG GGGCGCATCG TGGGACGCTT TGGCGGCAGT TGCTGGGCTT GGCTGCGACT ACCTCGTCAC GGGCGGCGAA GGCTACAGGC TGCCGGACCG TCGAACTTCC GTCGAATGAA GCGCGAGCGG GGGCTGCCGG CGGTGGCGAC CGATCCCGAC CGCCGGCGAG CCCGCAGCAG CCCGAGGTCC TGACACCGGC GGGAAGCGTC GGTAGACACG GCAGGGCGAG GTTCGTGGAG GCTGGTGCTC AACGGGAGCA CCTGGTCCTC ACTGACGGCC CTTGGCGAAG GGCTGGTGTT TCTGCGCCCG CCTCGTGTTG GGCGGCCAAC GAGATCATTG CGAGCAGGAT CCAGTTCGAC CITGTCCGAC CGTCAACAAA GCCGGATGCA GCTCGGATTC CGACTCGTTG GCCCX3CCACC CGCGCTGTCC CCTGCCCACG GATCTTGCAG GCTCAGATCG CTGATGCCTC GAGAAGCTCC CTGCACGAGG TACCCGGGTG GCCATCGGTG CCGGATCAGC TTCGACGCGG AGCGGGTCAT TGGAGGCGCA GTCAGACGCC TCAGGACGGT TCAGCAGGTG TGGAACGGGT GCCCACCGGG GCCTCTGGTC GCGTGCTCGT TGTGATCTGG TTCTCCCGTC GATGGAACCG AGGCX3GAACG GCGTCGAACG CTCACGAGTG ACGCGGCTTG ACCATGCCTC CTTGGCGCAG GTCAGCAGGC TACGGTGCCG GTGCTTGCCA CTCGACGACG AAGGTCGATG TTCTCGTCGG TCCTTCCTCG GCCTGGGGGC CGATTGGCGC GCCGCGTGCG GGGAACGCGA GCGGCGACTG GAACAACATC GCCGGTTCTC ACCGTGGTCG CTGGTGTTCA GCAGACCGCC CTGGCCAGGG AGCCTGGCGG GCCACGGACG AGCCGGAGCC GGGAGTACTT CGGAGTCGGG GGGTGCAGGA AATTCCCCGC CCGGAACCTG GATTCTTCGA TGGAAATCTC GCCGCACCGG CAGGAGAAGG GGGTTGCGTA CGTCGTTGGT CGCTGGCCGG AGCGTGGTCT GITGGGGTGA GGCATCGGGT GATTGACGGC CGGGGCTGTC GTGATCCGAT CGGTGTGGGA AGGTCGCCCG GCGGTCCCGC AGGTTTCCTT GCATCCCGGA GAGTGTCCGA GCGCGCGGAA TGTCGGGTGT ACGCATTGGC CCTGGGCGGA GATCTGGG1T TCAAGTTCTC CGGATGATGC GGATTCTGCT AGGAGATCAC AGTTGCGCAA ACTACCCGAC TGGCCGGGAC ATGAGGCCAC ACGTGTCCGG ACGAGCITTT TTCGCAACTT GCGGCGTGCG AGAGCGGGAA CCCGGAAGGG TGATCGTGGT CTACACCCGG CATCAGCCCC CTGGGAGACC GGTGTTCGCG TGTCGAAGGC TGCGTTCGGG GGCGCTGCAT TGGAGTGACG CGCACCGGAT GGGTGCCGGT ACTGGCGGTT CCCGAACGGG GGCGTCCGAT CGAGGCGCAG 34080 34140 34200 34260 34320 34380 34440 34500 34560 34620 34680 34740 34800 34860 34920 34980 35040 35100 35160 35220 35280 35340 35400 35460 35520 35580 35640 35700 35760 35820 35880 35940 36000 36060 36120 36180 36240 36300 36360 36420 36480 81 1237058 六、申請專利範圍 GCTCTGATAG CCGCCTATGG ACAGGATCGG GACCGGGACC GGCCGCTGTG GTTGGGGTCG 36540 GTCAAGTCCA ACATCGGTCA TACGCAGGCG GCTGCGGGCG TCGCTGGTGT GATCAAGATG 36600 GTCATGGCGA TGCGGCACGG GGAGCTGCCG CGCACGTTGC ACGTGGACGA GCCGAATTCG 36660 CACGTGGACT GGTCGGCTGG TGCGGTCCGA CTCCTGACCG AGAACATCCG CTGGCCAGGG 36720 ACGGGTACGC GCCGCGCTGG AGTGTCGTCG TTCX3GGGTAA GCGGTACCAA CGCACACGTC 36780 ATCCTCGAAC ACGACCCGCT CGCCGTGACC GAGAACGAGG AAGO^GCGCA GTCCCCAGCA 36840 CCTGGGATCG TGCCCTGGGC GTTGTCCGGG CX3GTCGTCGA CGGCGCTGCG GGCCCAGGCC 36900 GAACGGCTGC GCGAGCTGTG CGAGCAGACC GATCCCGACC CCGTCGATGT CGGTTTCTCA 36960 CTGGCCGCCA CGCGCACGGC TTGGGAGCAC CGAGCGGTGG TGCTTGGTCG GGACAGCGCT 37020 ACGTTGCGCT CCGGGCTTGG CGTTGTTGCC AGCGGTGAAC CAGCGGTCGA TGTCGTTGAG 3708。 GGGAGCGTCC TGGACGGCGA GGTCGTCTTC GTCITCCCCG GTCAGGGCTG GCAGTGGGCC 37140 GGTATGGCAG TCGACCTGCT GGACGCTTCG CCX3ACGTTCG CGCX3CCACAT GGACGAGTGC 37200 GCCACCGCGC TGCGGAGGTA CGTGGACTGG TCGTTGGTCG ACGTGCTGCG CGGAGCGGAG 37260 AACTCCCCAC CGCTGGACCG GGTGGACGTG CTCCAGCCCG CGTCCTTCGC GGTGATGGTG 37320 TCGCTCGCCG AGGTGTGGCG TTCCTACGGG GTGAGGCCGG CGGCCGTCGT CGGCCACAGT 37380 CAAGGCGAAA TCGCCGCGGC CTGCGCAGCC GGGGTGCTGC CGCTGGAGGA TGCGGCCAGG 37440 CTTGTCGCAT TGCGCAGCAG AGCGTTGAAG GGACTTTCGG GGCGGGGTGG CATGGCGTCG 37500 CTGGCCTGCC CTGCGGATGA GGTCGCGGCA TTGTTCGCGG GATCGGGCGG CCGTCTGGAA 37560 GTTGCGGCXSA TCAACGGCCC GCGATCGGTC GTGGTGTCCG GCGATCTGGA AGCX3GTGGAC 37620 GAACTGCTGG CAGAGTGCX5C TGAAAAGGAC ATGCGTGCAC GCCGTATCCC COTCGACTAC 37680 GCCTCGCATT CAGCGCACOT GGAGGTGGTT CGGAGCCCGG TGCTGGCGGC CGCCGCCX3GG 37740 GTGCGACACC GGGACGGCCA GGTGCCGTGG TGGTCGACGG TGATCGGCGA CTGGGTGGAT 37800 CCGGCGAGGC TGGACGGCGA GTATTGGTAT CGGAACCTCC GGCAGCCGGT CCGGTTCGAA 37860 CACGCCGTGC AGGGCCTGGT CGAGCGGGGA TTCGGCCTGT TCATCGAAAT GAGTGCGCAT 37920 CCGGTGCTGA CCACGGCGGT CGAGGAAACC GGTGCX3GAGT CGGAGACCGC CGTGGCCGCG 37980 GTAGGTACCT TGCGACGTGA CTCGGGCGGC CTCCGGAGGT TGTTGCATTC GCTGGCCGAG 38040 GCGTACGTGC GCGGCGCCAC CGTGGACTGG GCCGTGGCGT TCGGGGGCGC GGGCCGACGG 38100 CTCGACCTGC CGACCTACCC GTTCCAGCGC CAGCGGTACT GGCTGGACAA GGGAGCTGCC 38160 TCCGACGAGG CTCGTGCGGT CTCGGACCCG GCX3GCGGGCT GGTTCTGGCA AGCCGTGGCG 38220 CGCCAAGACC TGAAAAGCGT GTCCGATGCC CTCX5ATCTCG ACGCCGACGC ACCGCTGAGC 38280 GCAACACTTC CAGCCCTGTC CGTCTGGCAC CGTCAGGAAC GAGAAAGGGT CTTGGCAGAC 38340 GGTTGGCGGT ACCGAGTCGA CTGGGTACGG GTGGCCCCGC AGCCGGTCCG GAGAACGCGG 38400 GAAACCTGGC TCCTGGTCGT TCCCCCX3GGC GGCATCGAGG AAGCGCTGGT CGAACGGCTG 38460 ACGGATGCGT TGAACACGCG AGGGATCAGC ACCCTGCGCC TCGACGTGCC ACCGGCGGCG 38520 ACCAGTGGCG AACTCX3CAAC CGAACTCCGC GCCGCAGCCG ACX3GTGACCC GGTGAAGGCA 38580 ATCCTGTCGC TCACCGCGTT GGACGAGCGA CCCCACCCCG AATGCAAGGA CGTCCCGAGC 38640 GGGATTGCCT TG(nOCTGAA CCTGGTCAAG GCGCTCGGTG AAGCCGACCT CAGAATTCCT 38700 CTGTGGACCA TCACX5CGTGG TGCGGTCAAG GCAGGCCCCG CAGATCGGCT GCTGCGCCCG 38760 ATGCAGGCGC AAGCATGGGG TCTGGGGCGA GTAGCCGCAC TCGAACACCC CGAGCGCTGG 38820 GGTGGGCTGA TCGACCTGCC GGATTCGCTG GACGGCGACG TCCTCACGAG GCTGGGCGAA 38880 GCGCTCACCA ACGGCTTGGC GGAAGACCAA CTGGCGATTC GCCAGTCGGG CGTGCTGGCC 38940
1237058 六、申請專利範圍 CGGCGACTGG TACCCGCCCC GGCGAATCAG CCCGCTGGAC GTAAGTGGCG CCCCCGAGGG 39000 AGCGCGCTGA TCACGGGCGG ACTCGGCGCG GTGGGCGCAC AGGTGGCGAG GTGGTTGGCC 39060 GAAATCGGAG CCGAGCGAAT CGTGCTCACC AGTCGACGGG GCAACCAAGC AGCAGGCGCC 39120 GCCGAGCTGG AAGCCGAACT CCGGGCCCTT GGAGCGCAAG TGTCCATCGT GGCTTGCGAC 39180 GTGACCGATC GTGCCGAGAT GTCCGCACTA CTGGCCGAGT TCGACGTCAC CGCGGTGTTC 39240 CACGCGGCCG GAGTCGGTCG GCTGCTGCCG TTGGCGGAGA CCGACCAGAA CGGCCTGGCC 39300 GAAATATGCG CGGCGAAGGT CCGCGGCGCT CAGGTGCTGG ACGAACTGTG CGACAGCACC 39360 GATCTCGATG CCTTCGTCCT GTTCTCCTCG GGTGCCGGGG TATGGGGCGG GGGCGGTCAG 39420 GGCGCTTACG GCGCGGCGAA CGCATTCITG GACACACTCG CCGAACAACG CCGAGCACGC 39480 GGTCTGCCGG CAACCTCGAT CTCCTGGGGC AGTTGGGCCG GCGGCGGCAT GGCCGACGGC 39540 GCGGCGGGCG AACACCTGCG GCGACGCGGG ATACOTCCGA TGCCGGCGGC GTCGGCCATC 39600 CTGGCTCTGC AGGAAGTACT TGACCAGGAT GAGACGTGCG TGTCGATCGC TGATGTGGAC 39660 TGGGACCGAT TCGTTCCCAC GTTCGCCGCG ACTCGCGCCA CCCGGTTGTT CGACGAAGTG 39720 CCGGCGGCGA GAAAGGCGAT GCCCGCGAAT GGGCCGGCAG AACCAGGCGG CTCGCCGTTC 39780 GCCCGCAATC TCGCGGAGCT GCCGGAAGCC CAACGACGCC ACGAACTGGT GGATCTGGTG 39840 TGCGCCCAGG TGGCAACCGT GCTCGGGCAC GGCAGTCGCG AGGAAGTCCA GCCCGAGCGG 39900 GCGTTCCGCG CGCTCGGGTT CGACTCCCTC ATX3GCGGTGG ATCTGCGCAA TCGTTTGACC 39960 ACCGCCACCG GGTTGCGCCT GCCGACCACA ACCGTCTTCG 40000 ACTACCCGAA TCCGGCCGCC TTGGCCGCTC ACCTGCTCGA GGAGCTGGTG GGTGATGTCG 40060 CGTCGGCTGC GGTGACCGCT GCCAGCGCGC CCGCGAGTGA CGAACCGATC GCGATCGTCG 40120 CGATGAGCTG CCGGTITCCG GGTGGCGCGC ACTCGCCGGA AGACCTGTGG CGGCTGGTCG 40180 CCGCCGGCAC GGAGGTGATC GGCGAGTTCC CCTCCGACCG GGGCTGGGAT GCGGAAGGCC 40240 TTTACGATCC GGATGCTTCC AGGCCTGGAA CGACGTATGC GCGGATGGCG GGATTCCTCT 40300 ACGACGCCGG TGAGTTCGAT GCCGACCTGT TCGGCATCAG CCCACGTGAG GCGTTGGCGA 40360 TGGATCCGCA GCAGCGGTTG GTGCTCGAAA TCGCCTGGGA AGCCCTCGAA CX3GGCCGGAA 40420 TCGATCCGTT GTCCTTGAAG GGCAGTGGGG TCGGCACGTA CATCGGCGCT GGAAGCCGTG 40480 GGTACGCGAC GGATGTGCX3G CAGTTTCCCG AGGAGGCGGA GGGCTACCTG CTGACGGGTA 40540 CCTCGGCCAG TGTGCTGTCG GGTCGGGTCG CGTATTCGTT TGGTTTCGAG GGTCCTGCGG 40600 TGACGGTGGA TACGGCTTGT TCGTCGTCGT TGGTGGCG1T GCATCTGGCG TGCCAGTCGT 40660 TGCG1TCGGG CGAGTGTGAT CTGGCGTTGG CCGGTGGTGT GACCGTGATG TCGACGCCGG 40720 AGATGTTCGT GGAGTTCTCC CGTCAGCGCG GTITGGCGCC GGATGGGCGG TGCAAGTCGT 40780 TCGCGGAGAG CGCGGACGGC ACCGGCTGGG GCGAAGGCGC GGGCCTGTTG TTGCTGGAGC 40840 GGTTGTCGGA CGCCCACCGG AATGGGCATC GGGTGTTGGC GGTGGTTCGT GGGTCAGCGG 40900 TGAATCAGGA CGGCGCCTCO AACGGACTGG CGGCGCCGAA CGGTCCGTCG CAGCAGCGGG 40960 TGATCAACCA GGCACTCGCG AATGCGGCTC TTTCGGCGTC CGATGTGGAT GCGGTGGAGG 41020 CACATGGCAC CGGGACCAGG CTGGGTGATC CGATCGAGGC GCAGGCATTG ATCGCAACGT 41080 ATGGGCAGGC CCGGGAGCGG GATCGGCCCT TGTGGCTGGG GTCGGTCAAG TCGAACATCG 41140 GTCATACGCA GGCCGCGGCG GGTGTTGCCG GTGTGATCAA GATGGTGATG GCCATGCGGC 41200 ACGGGCAGCT GCCCGCCTCG CTGCACGCGG ATGAGCCCAC GTCGGAGGTC GATTGGTCGT 41260 CGGGGGCGGT CCGGCTCCTC GCCGAACAGG TACCTTGGCC GGAGTCTGAC CGTGTTCGTC 41320 GGGTGGGGGT TTCGTCGTTC GGGATCAGCG GCACCAACGC ACATGTGATC CTCGAACAAG 41380
1237058 六、申請專利範圍 CTACGAATGC GCCAGATAGT ACAGCX3GAGA CGGACAAAAC AGAATCCGGA TCTACTGTCG 41440 ATATTCCGGT CGTTCCCTGG 1TGGTGTCGG GAAAGACGAC GGATTCCCTG CGGGGACAAG 41500 CCGAACGAGT CITGTCTCAG GTCX3AGTCCC GGCCGGAGCA GCGTTCGCTG GATGTTGCCT 41560 ACTCGCTTGC TTCTGGCCGA GCCGCGCTGG ATGAACGCGC TGTCGTGCTG GGTGCX3GACC 41620 GCGGTGAGCT GGTIOCTGGA CTGGCGGCGT TGGCCGCCGG TCAGGAGGCT TCTGGGGTGA 41680 TCAGCGGAAC TCGTGCTTCT GCTCGGTTCG GGTTCGTGTT CTCGGGGCAG GGTGGTCAGT 41740 GGTTGGGGAT GGGCAGAGCG CTCTACTCGA AGTITCCGGT GTTCGCTGCT GCGTTTGATG 41800 AGGCTTGCGC CGAGTTGGAG GCACATCTGG GGGAAGACCG CCGGGTTCGG GATGTGGTCT 41860 TCGGTTCCGA TGCGCAGCTG CTGGA.TCAGA CGCTGTGGGC GCAGTCX3GGT CTGTTCGCGC 41920 TGCAAGCCGG CCTCTTGGGG CTCCTGGGTT CGTGGGGCGT TCGGCCGGAT GTGGTGATGG 41980 GGCATTCGGT CX3GGGAG1TG GCCX3CCX3CGT TTGCGGCTGG CGTGTTGTCG TTGCGGGATG 42040 CGGCTCGGTT GGTGGCCGCG CGCGCCCGGT TGATGCAAGC CCTGCCCTCT GACGGCGCX3A 42100 TGTTGGCGGT GGCTGCTGGT GAAGACCITG TTCGGCCATT GCTGGCCGGT CGGGAGGAGT 42160 CCGTGAGCGT CX3CCX3CX3CTC AATGCCCCCG GTTCX3GTGGT GTTGTCGGGC GATCGGGAGG 42220 TGCTGGCCAG CATCGTCGGC CGGCTGACCG AGCTCCGAGT CCGGACGCGG CGCTTGCGGG 42280 TCTCCCATGC TTITCATTCG CACCGGATGG ACCCGATGTT GGGCGAGTTC GCCCAGATCG 42340 CCGAGTCTGC GGAGTTCX3GT AAGCCAACGA CACOSCTTGT GTCX^ACGTTG ACGGGTGAGC 42400 TCGACAGAGC CX3CGGAAATG AGCACACCAG GGTATTGGGT GCGCCAGGCG CGTGAACCCO 42460 TCCGTITCGC CGACGGTGTC CAGGCCCTGG CAGCGCAGGG CATAGGCAOG GTCGTCGAGC 42520 TCGGCCCGGA CGGAACGCTG GCGGCACTGG TTCGGGAGTG TGCGACCGAG TCCX3ATCGGG 42580 TTGGGCGGAT TTCGTCGATC CCACTGATGC GCAGGGAGCG GGACGAGACC CGTTCX^GTGA 42640 TGACAGCCCT GGCGCATCTC CACACCCX5TG GTGGTGAGGT GGACTGGCAG GCGTTTTTCG 42700 CCX3GTACCGG CGCTAGGCAG CTCGAGTTGC CAACX3TATGC CTTCCAACX5A CAGCACTACT 42760 GGATCGAGTC CAGTGCGCGG CCAGCACGCG ACCGCGCAGA CATCGGCGAG GTGGCX3GAAC 42820 AGTTCTGGAC CGCGGTTGAC CAAGGCGATC TGGCAACGTT GGTCGCCGCT CTGGATCTTG 42880 GGGCGGACGA CGACACATGC GCATCX3TTGA GCGATGTATT GCCGGCOTTG TCCTCCTGGC 42940 GAAGCGGACT CCGCAACCGT TCGCTCGTCG ATTCCTGCCG GTACCGAATC AGTTGGCATT 43000 CCTCTCGGGA GGTGCCGGCC CCGAAGATTT CCGGTACCTG GCTGTTGGTC GTGCCCX3GTG 43060 CTGCGGATGA CGGATTGGTC ACGGCTTTGA CGAGTTCACT GGTCGGAGGC GGCGCCGAGG 43120 TCGTCCGGAT CGGCCTGTCC GAAGAGGACC CGCACCGCGA GGACX5TCGCA CAGCGGCTGG 43180 CCAATGCGCT GACGGATGCC GGTCAACTCG GTGGCGTGCT TTCGCTGTTG GGGCTCX3ATG 43240 AATCGCCTGC TCCGGGA1TC TCCIOCTTGC C^CTGGTTT CGCGCTGACT GTGCAGCTTC 43300 TGCGGGCCIT GCGGAAGGCC GACGTCX3AGG COCCTTTITG GGCGGTGACG CGCGGCGGCG 43360 TCGCGTTGGA AGATGTACGC GTGTCTCCGG AGCAGGCCCT GGTCTGGGGG CTGCTGCGTG 43420 TCGCGGGACT GGAGCACCCG GAGTTCTGGG GTGGCTTGAT CGACCTGCCA TCGGACTGGG 43480 ACGACCGATT GGGTGCCCGG TTGGCGGGTG TGTTGGCGGA TGGTGGCGAG GATCAAGTCG 43540 CCATTCGCCO TGGTGGTGTG TTCGTGCGGC GGTTGGAACG CGCTGGTGCG TCGGGTGCCG 43600 GGTCGGTGTG GCGTCCTCGG GGGACGGTGT TGGTGACGGG TGGTACGGGC GGTTTGGGGG 43660 CGCATGTTGC CCGGTGGTTG GCCGGTGCCG GGGCTGAGCA CGTGGTGTTG ACCAGCCGTC 43720 GAGGAGCGGA CGCTCCGGGC GCTGGGGAAT TGCGGGCGGA GCTGGAGGCG CTGGGTGCTC 43780 GGGTGTCGAT TGTGCCCTGC GACGTGGCTG ATCGTGACGC AGTGGCTGGA GTGTTGGCAG 43840
1237058 六、申請專利範圍 GGATCGGTGG GGAGTGTCCX； CTGACTGCGG TGGTACACGC CGCCGGGGTC GGCGAGGCGG 43900 GCGACXBTAGT GGAGATGGGT TTGGCGGATT TTGCAGCGGT GTTGTCGGCO AAGGTGCGTG 43960 GTGCGGCGAA TCTGGACGAG TTGCTGGCCG ACTCX3GAGCT GGATGCGTTT GTGATGTTCT 44020 CCTCGGTGTC GGGGGTGTGG GGAGCCGGCG GACAGGGTGC GTATGCGGCT GCGAACXX：CT 44080 ACTTGGATGC GTTGGCCGAG CAGCGTCGGG CGAGGGGA1T GGTCX3GGACC GCGGTTGCGT 44140 GGGGACCGTG GGCCGGTGAC GGCATGGCCG CCGGCGAAAC CGGCGCACAG CTGCACCX3GA 44200 TGGGCCTGGC GTCGATGGAA CCGAGCGCGG CGCTGCTGGC ACTTCAGGGT GCATTGGACC 44260 GCGATGAGAC CTCCCTCGTC GTGGCCGATG TCGATTGGGC ACGGTTCGCC CCAGCCTTCA 44320 CCTCGGCACG TCGACGCCCG CTGCTGGACA CCATCGACGA GGCCCGAGCC GCATTGGAAA 44380 CCACCGGCGA ACAAGCGGGC ACAGGCAAAC CCGTTGAGCT GACGCAACX3C CTGGCCGGAC 44440 TGTCGCGGAA GGAACGCGAC GATGCGGTAT TGGATCTGGT GCGGGCGGAG ACGGCGGCTG 44500 TGCTGGGACG CGACGATGCC ACGGCCCTGG CGCCATCGCO GCCOTTCCAG GAACTCGGAT 44560 TCGACTCCTT GATGGCGGTG GAGCTGCGCA ACCGGCTGAA CACCGCCACC GGGATCCAGC 44620 TGCCCGCCAG CACGATTITC GACTACCCCA ATGCCGAGTC GCTGTCGCGT CACCTCTGCG 44680 CCGAGCTTTT CCCAACGGAG ACTACCGTGG ACTCGGCCCT TGCCGAGCTC GATCGAATCG 44740 AGCAGCAGCT CTCGATGCTC ACCGGCGAAG CGCGGGCACG GGACCGAATC GCGACACGAC 44800 TGCGAGCCCT CCACGAGAAG TGGAACAGCG CAGCTGAAGT ACCGACCGGA GCCGATGTCC 44860 TGAGCACGCT CGA1TCGGCG ACGCACGACO AGATATTCGA G1TCATCGAC AACGAGCTCG 44920 ACCTGTCCTG AGCAGTTCCT GCGGAACTTC AAGCGCCGAA ATCGGGTGGA AATCACAATG 44980 GCCAATGAAG AAAAGCTCTT CX3GCTATCTG AAGAAGGTAA CTGCGGACCT GCATCAGACC 45040 CGGGAGCGCC TGCTCGCGGC CGAGAGCCGG AGTCAGGAGC CGATCX3CGAT CGTCTCX3GCG 45100 AGCTGCCGAC TGCCCGGCGG CGTCGACTCT CCCGAAGCGC TCTGGCAACT CGTGCGCACT 45160 GGCACCGACG CCATCTCGGA GTTCCCCX3CC GACCGGGGCT GGGATCTCGG CCGGTTGTAC 45220 GATCCCGACC CGAACCACCA GGGAACGTCG TACACGCGGG CCGGCGGTTT CCTCGCAGGA 45280 GCX3GGCGATT TCGACCCCGC CATGTTCGGG ATTTCGCCGC GTGAGGCGTT GGCGATGGAC 45340 CCGCAGCAAC GGTTGTTGCT GGAGCTGTCC TGGGAGGCCC TCX3AACX3GGC GGGCATAGAC 45400 CCGACATCCC TGCGCGGCAG CAAGACCGGT GTCTTCGGTG GTGTCACGCC CCAGGAGTAC 45460 GGGCCGTCCT TGCAGGAGAT GAGCCGAAAC GCTGGGGGTT TTGGACTCAC CGGGCGGATG 45520 GI^GAGTGTGG CGTCGGGTCG GGTTGCGTAT TCGTTTGGTT TTGAGGGTCC TGCGGTGACG 45580 GTGGATACGG CGTGTTCGTC GTCGTTGGTG GCCCTGCATT TGGCGTGTCA GTCGTTGCGT 45640 TCCX3GCGAAT GCGATCTC!GC GCTGGCCX3GC GGTGTGACGG TGATGGCGAC ACCGGCGACG 45700 1TCGTGGAGT TCTCCCGTCA GCX3TGGTTTG GCTCCGGACG GGCGGTGCAA GTCGTTCGCG 45760 GCTGCCGCGG ATGGCACCGG GTGGGGTGAG GGTGCCGGTC TGGTGTTGCT GGAGCGGTTG 45820 TCGGATGCGC GGCX3GAATGG GCACGAGGTT CTGGCGGTGG TGCGGGGTAG CGCGGTGAAC 45880 CAGGACGGCG CGTCGAATGG TTTGACTGCG CCGAATGGTC CGTCGCAGCA GCGGGTGATC 45940 ACCCAGGCGT TGGCGAGTGC GGGGCTGTCG GTTTCCGATG TGGATGCGGT CGAGGCACAT 46000 GGGACCGGGA CCACX3TTGGG TGATCCGATC GAGGCACAGG CCCTGATCGC CACOTACGGG 46060 CAGGGCCGGG AGAAGGATCG GCCGTTGTGG 1TGGGGTCGG TCAAGTCCAA CATCGGTCAC 46120 ACGCAGGCGG CCGCTGGCGT TGCCX3GCGTC ATCAAGATGG TCITGGCGAT GCGGCACGGG 46180 CAGCTGCCCG CCACGTTGCA TGTGGATGAG CCCACGTCGG CGGTGGACTG GTCGGCGGGT 46240 TCX3GTCCGGC TTCTCACGGA GAACACGCCC TGGCCGGACA GTGGTCGTCC TTGCCGGGTG 46300
85 1237058 六、申請專利範圍 GGGGTGTCGT CGTTCGGGAT CAGCGGCACC AACGCACATG TGATTCTCGA ACAGTCTCCA 46360 GTCGAGCAGG GCGAACCGGC CGGGCCGGTC GAAGGCGAGC GGGAACCGGA TGTAGCCGTC 46420 CCCGTGGl^GC CITGGGTGCT GTCGGGTAAG ACACCGGAGG CTGCX3CGGGC GCAGGCCGAA 46480 CX3GGTGCA1T CGCATATCGA GGACCGGCCG GGGCTGTCGC CGGTGGATGT GGCGTATTCG 46540 CTAGGAATGA CACGCGCX3GC GCTGGATGAA CX5CGCAGTGG TGTTGGGCTC GGACCGTGCC 46600 GCGCTCCTGA CCX3GGTTGAG GGCATTCGCC GACGGCTGCG ATGCGCCCGA AGTGGTTTCG 46660 GGGTCTGTGG GGCTTGGTGG CCGCiGTCGGG TTCGTGTTCT CGGGTCAGGG TGGTCAGTGG 46720 CCGGGGATGG GCCGGGGGCT CTACTCGGTG TTTCCGGTGT TCGCCGACGC GTTCGACGAG 46780 GCTTGCGCGG AGTTGGATGC ACACCTGGGC CAGGAACTGC GGGTTCGGGA TGTGGTGTTC 46840 GGTTCGCAAG CGTGGTTGCT GGATCGGACG GTGTGGGCGC AGTCGGGTTT GTTCGCGTTG 46900 CAGATTGGCT TGCTGCX3GCT GCTGGGTTCG TGGGGTGTTC GGCCX3GATGT GGTGTTGGGG 46960 CACTCX3GTGG GTGAGCTGGC TGCGGTGCAT GCGGCTGGTG TGTTGTCGTT GTCX3GAGGCC 47020 GCXXX3G1TGG TGGCGGGTCO CGCCCX3GTTG ATGCAGGCGT TGCCTTCTGG TGGTGCCATG 47080 CTCX3CGGTCG CTACGGGTGA GTTTCAGGTC GATCCTCTGC TGGATGGGGT GCGGGACCGG 47140 ATCGGTATCG CJGGCGGTGAA TGGCCCGGAA TCGGTTGTGC TCTCTGGTGA CCGCGAGCTG 47200 CTCACCGhGA TCGCTGATCG GTTGCACX3AT CAGGGGTGCC GGACCCX3GTG G1TGCX3GGTG 47260 TCGCATGCTT TCCATTCX3CC CCATATGGAG CCGATGCTGG AGGAGTTC!GC CCAGATCTCC 47320 CGAGGCCGCG AATATCACGC ACCGGAACTG CCGATCATCT CGACCCTGAT CGGTGAGCTG 47380 GACX3GTGGTC GAGTGATGGG CACTCCCGAG TACTGGGTGC GTCAGGTGCG TGAGCCCX3TC 47440 CGTTTCGCCG AGGGTGTCCA GGCGCTTGTC GGTCAGGGTG TCX3GCACGAT TGTCJGAATTG 47500 GGTCCGGACG GGGCGTTGTC GACGTTGGTC GAGGAGTGTG TGGCGGAATC CGGGCGGGTG 47560 GCCX3GGATCC CX3CTGATGCX3 CAAGGACCGC GACGAGGCGC GAACCGTGCT GGCAGCITTG 47620 GCGCAGATCC ACACCCGTGG TGGTGAGGTG GACTGGCGGT CGTTTTTCGC CGGTACCGGG 47680 GCGAAGCAAG TCGACCTGCC CACCTACGCC TTCCAGCGGC AGCX3GTACTG GCTGGCATCC 47740 ACCGGGCGTG CGGGTGACX5T GACCGCCGCC GGATTGGCCO AGGCGGACCA TCCGCTGCTC 47800 GGTGCGGTGG TTGCGTTGGC AGACGGCGAA GGTGTGGTGC TGACCGGTCG GTTGACAGCG 47860 GGTTCJGCATC CGTGGTTGTC CGATCACCGG GTGCTGGGCG AAATCGTCGT CCCCGGCACC 47920 GCGATCGTCG AGCTGGTGTG GCACGTCGGC GAGCGCCTCG GTTGTGGCCG GGTGGAAGAA 47980 CTCGCTTTGG AAGCGCCCCT GATCCTGCCG GATCATGGAG CGGTCCAGGT TCAGGTGCTG 48040 GTGGGACCGC CCGGGGAATC CGGAGCCCGG TCGGTGGCX3C TCTACTCCTG TCCTGGCGAG 48100 GCGATOHAAC CCGAGTGGAA GAAGCACX5CG ACGGGCGTGC TTCTCCCACC CGTGGCCGCC 48160 GAGAACCATG AGCTGACCGC ATGGCCCCCG GAGAATGCGA CCGAAATCGA TGCAQACGGG 48220 GTCTACGCAT TCCTTGAAGG GCACGGTTTC GCGTACGGAC CGGCCTTTAG ATGTCTGCGC 48280 GGTGCCTGGC GACGAGGCGG GGAGGTGTTC GCCGAAGTCO CATTGCCGGA TGACATGCAG 48340 GCGGGGGTCG ATCGATTCX^ CGTCCACCCC GCGTTGCTGG ACGCX3GTTCT GCATGCCGCC 48400 GCAGCCGAGA CGTCX3GIX3GT CCAGAGCGAA GCGCGGGTGC CGTTCTCGTG GCGTGGGGTG 48460 GAACTTCGCG CCACTGAAAG CGCGGTGGTG CGGGCGCGCC TCTCGTTGAC TTCX^ATGAC 48520 GAACTGTCX3T TGGTCGCAGT GGACCCGGCT GGCCGATTCG TGGCCACX3GT TGATTCX5CTG 48580 GTGACCCGAC CGATCTCCCX3 GCAGCAGGTG AGGTCTGGCG CGATCX3GTGA TTGCCTGITC 48640 GAGGTGGAGT GGCACCX^GAA GGCGTTGTTG GGAACAACCG CCGGCGACGA CCTTGCCATC 48700 GTCGGTGACG GTCCCAGTTG GCCGGAATCG GTGCGCGCAA CCGCACGGTT CGCGACCCTG 48760
1237058 六、申請專利範圍 GATGAGTTCC GTGCGGCCGT GGACTCGGAC GTTCCTGCCC CX3GGTTCGGT GTTGGTCGCA 48820 GCTATGTCGG CCGAAGAGGT CX5AGGGTGGA TCCCTGCCGT CGCGCGCCCA AGAGTCGACC 48880 TCCX5ATCTGC TGGCTCTCGT GCAGTCGTGG CTTGCGGACG AGCGGTTCGC CGAATCCCAG 48940 CTCX3TGGTCO TCACGCGTGC AGCX3GIOTCG GCCGACTCGG ATTCGGACGT CGCGGACCTG 49000 GTGGGTGCGT CGTCGTGGGG GTTGTTGAGT TCAGCCCAGT CGGAGAACCC GGGTCGCTTC 49060 GTGCTGGTGG ACGTGGACGG CACACCTGAG TCGTGGCAGG CGTTGCCGGC CGCCGTGCGA 49120 GCAGGAGAAC CGCAGCTGGC ACTTCGGCGC GGCGTGGCGC TGGTGCCTCG GTTGGCGCGA 49180 CTCACGGTGC GCGAGGAGGG CTCCTCCCCG CAACTCGACA CX3GACX3GGAC CGTCCTCATC 49240 ACGGGTGGCA CCGGTGCGTT GGGGGGAGTG G1TGCCCOTC ACCTGGTGGA GGAGCACGGG 49300 ATTCGGCGTT TGGTGTTGGC AGGCCGGCGT GGCTGGAATG (^CTGGAGT CCACGAGTTG 49360 GTGGATGAGC TGGCX3CGCGC GGGCGCCGTG GTTGAGGTGG TGGCTTGCGA TGTGGCTGAC 49420 CGCACCGATC TGGAGCACGT GCTGGCCGCC ATTCCGGTCG ACTGGCCGCT GCX3GGGGATC 49480 GTGCATACCG CTGGGGTGCT GGCCGACX3GA GTGATCGGGT CCTTGTCX3GC GGCGGATGTG 49540 GGCAOGGTGT ITGCCCCGAA GGTGACJGGGG GCATGGCATC TGCACGAGTT GACCCGCX5AT 49600 CTGGATCTGT CGTTCTTCGT TCTTITCTCT TCCTTCTCCX3 GGATTGCX3GG TGCCGCAGGG 49660 CAGGCCAACT ACGCGGCGGC GAACACGITC CTGGATGCAT TGGCGCGTTA TCGCCGGGCX； 49720 CGTGGGCTGC CTGGGTTGTC GTTGGCGTGG GGACTGTGGG CGCAACCCAG CGGTATGACG 49780 AGTGGCTTGG ACGCGGCX3TC GGTGGAGCGG TTGGCGCGGA CGGGCATCGC AGAACTTTCC 49840 ACGGAGGATG GACTCCGCCT GTTCX^TGCC GCGTTCGCGA AGGACCGGGC TTGCGTCGTT 49900 GCCGCTCGAT TGGACAGGGC GCTGCTGGTC GGGAACX3GAC GATCX3CACGC GATTCCGGCG 49960 CTGTTGAGCG CGTTGGTTCC TGTTCGCGGC GGTGTGGCGA GGAAAACAGC CAATTCTCAG 50020 GCCGCGGATG AGGACX5CACT GITGGGTTTG GTGCOGGAGC ACGTTTCX3GC CGTGCTGGGT 50080 TATTCGGGTG CGGTCGAGGT TGGGGGCGAC CGTGdTTCC GTGATCTGGG TTTTGATTCG 50140 TTGTCTGGCO TGGAGTTGCG GAACCGCCTT GCCGGGGTGC TGGGGGTGCG GTTGCCGGCG 50200 ACTGCGGTGT TCGACTATCC GACGCCGCGG GCGCTGGCGC GTTTCCTGCA TCAGGAACTG 50260 GCAGGCGAGG TCGCGTCCAC GTCX5ACGCCG GTGACCAGGG CAGCGAGTGC CGAAGAGGAT 50320 CTTGTTGCGA TTGTCGGGAT GGGATGTCGT TTTCCGGGTG GGGTGTCGTC GCCGGAGGAG 50380 CTTTGGCGGC TGGTGGCCGG CGGCGTGGAT GCGGTGGCTG GGTTCCCAGA CGATCGCGGC 50440 TGGGATCTCG CGGCG1TGTA CGATCCTGAT CCCGATCX5TC TCGGGACCTC GTATGTGTGT 50500 GAGGGCGGGT TTCTGCGGGA CGCGGCGGAG TTCGATGCTG ACATGTTCGG CATCAGCCCG 50560 CGTGAGGCGT TGGCGATGGA TCCGCAGCAG CGGTTGCTGC TGGAGGTCGC CTGGGAAACC 50620 TTGGAGCGGG CTGGGATCGA TCCGTTCTCG TTGCACGGCA GCCGGACCGG TGTGTTCGCG 50680 GGCTTGATGT ACCACGACTA TGGGGCCCGA TTCATTACCA GAGCACCGGA GGGCTTCGAA 50740 GGGCACCTCG GGACGGGCAA TGCGGGGAGC GTGCTGTCGG GTCGGGTTGC GTATTCGTTT 50800 GGTTTCGAGG GTCCTGCGGT GACGGTGGAT ACGGCGTGTT CGTCGTCGTT GGTGGCGTTA 50860 CACCTGGCGG GTCAAGCACT GCGGGCCGGT GAGTGCGAAT TCGCCCTTGC CGGTGGCGTC 50920 ACGGTGATGT CGACGCCGAC GACGTTCGTG GAGTTCTCCC GTCAACGGGG TCTGGCTCCG 50980 GATGGGCGGT GCAAGTCGTT CGCGGCGGCC GCGGATGGCA CCGGGTGGGG CGAGGGTGCC 51040 GGTCTGGTGT TGCTGGAGCG GTTGTCGGAT GCCCGGCGCA ATGGGCACGA GGTTCTGGCG 51100 GTGGTGCGGG GTAGCGCGGT GAACCAGGAC GGCGCGTCGA ATGGCTTGAC TGCGCCAAAT 51160 GGTCCGTCAC AGCAAAGGGT GATCACCCAG GCACTCACGA GTGCCGGGCT GTCCGTGTCC 51220
8 7 1237058 六、申請專利範圍 GACGTGGATG CTGTGGAGGC GCATGGGACG GGCACGCGGC TTGGTGATCC GATCGAGGCG 51280 CAGGCGTTGA TCGCTACX3TA CGGCCGGGAT CGTGATCCCG GTCGGCCGTT GTGGCTGGGG 51340 TCGGTGAAGT CGAATATTGG TCACACCCAG GCGGCGGCGG GTGTCGCTGG TGTGATCAAG 51400 ATGGTGATGG CGATGCGGCA GGGGGAGCTG CCGCGCACGT TGCACGTGGA CGAGCCCTCC 51460 GCGCAGGTGG ACTGGTCTGC GGGCACGGTC CAACTCCTCA CGGAGAACAC GCCCTGGCCC 51520 GACAGCGGTC GTCTTCGCCG GGCGGGCGTG TCATCGTTCG GGATCAGTGG CACCAACGCG 51580 CACCTGATCC TTGAACT^ACC TCCGCGAGAG TCGCAGCGCT CAACAGAGCC GGA1TCGGGT 51640 TCTGTCCGCG ATTTTCCGGT GGTGCCGTGG ATGGTGTCGG GCAAAACACC CGAAGCGCTA 51700 TCCGCCCAGG CAGATGCATT GATGTCCTAC TTGAGCAATC GCGTTGATGC TTCCCCGCGA 51760 GATATCGGTT ATTCGCTTGC GGTGACCCGT CCGGCGTTGG ACCACCGCGC TGTCGTGCTG 51820 GGTGCGGATC GTGCCX3CGTT GCTGCCGGGC TTGAAAGCGC TGGCCGTTAG TAATGACGCT 51880 GCCGAGGTGA TCACCX3GCAC TCGTGCCGCT GGGCCGGTCG GATTCGIOTT CTCCGGTCAA 51940 GGTGGTCAGT GGCCCGGGAT GGGAAGCGGG CTCCACTCGG CGTTTCCGGT GTTCGCCGAC 52000 GCGTTTGACO AAGCCTGCTG CGAGCTGGAT GCGCATCTCG GGCAGATGGC CCGGCTACGA 52060 GATGTGTTGT CCGGITCXSGA TACGCAACTT CTGGACCAGA CCTTGTGGGC GCAGCCGGGC 52120 CTGTTCGCGT TGCAAGTCGG ACTCTGGGAG TTGTTGGGTT COTGGGGTGT CCX3GCCCGCT 52180 GTGGTGCTGG GCCACTCGGT CGGTGAGCTG GCGGCX3GCGT TCGCGGCTGG AGTG1TGTCX3 52240 TTGCGGGATG CX3GCTCGGCT GGTGGCGGGC CGTGCCCGGT TGATGCAAGC CCTGCCAACT 52300 GGCGGTGCCA TGCTCGCTGC GGCIOCTGGA GAGGAGCAGC TGCGCCCGTT GCTGGCCGAC 52360 TGCGGTGATC GTGTGGGGAT CGCCGCGGTC AACGCTCCCG GGTCGGTGGT GCTCTCCGGT 52420 GATCGGGATG TGCTCGATGA CATTGCCGGT CGGCTGGACG GGCAAGGGAT CCGGTCCAGG 52480 TGGTTGCX3GG TTTCX5CATGC GTTTCATTCG CATCGGATGG ATCCGATGCT GGCX^GAGITC 52540 ACCGAAATCG CCCGGAGCGT GGACTACCGG TCGTCAGGGC TGCCGATCGT GTCX^ACGTTG 52600 ACGGGTGAGC TCGATGAGGT CGGCATGCCG GCTACGCCGG AGTATTGGGT GCGCCAGGTG 52660 CGAGAACCCG TCCGCTTCGC CGACGGTGTT GCTGCGCTCG CGGCTCACGG TGTGAGCACC 52720 GTCGTCGAGG TCGGTCCGGA TGGGGTGTTG TCGGCGCTGG TGCAGGAGTG CGCGGCCGGA 52780 TCCGATCAGG GCGGACX3GGT GGCCGCGGTT CCGCTCATGC GCAGCAATCG CGACGAGGCG 52840 CACACGGTGA CAACGGCATT GGCGCAGATC CATGTGCGTG GTGCTGAGGT GGACTGGCGG 52900 TCGTmTCG CCGGTACCGG GGGAAAGCAG GTCGAGCTGC CCACGTATGC CTTCCAACGA 52960 CAGCGGTACT GGCTTGACTC ACCATCCGAA CCGGTCGGGC AATCCGCCGA TCCCGCGCGC 53020 CAGTCGGGCT TCTGGGAACT CGTCGAGCAG GAAGATGTCA GCGCGCTCAG CGCCGCTCTG 53080 CACATTACCG GCGATCACGA CGTGCAGGCG TCCCTGGAAT CGGTGGTTCC GGTCCTCTCC 53140 TCCTCGCATC GCCGGATCCG CAACGAATCC CTGGTGCACC AGTGGCGGTA CCGGATTTCC 53200 TCGCATGAGC GGGCAGATTT GCCAGACCCC TCGTTGTCGG GGACATGGCT CGTCGTCGTG 53260 CCGGAGGGGT GGTCGGCGAG TCGGCAAGTT CTGCGTITCA ACGAGATGTT CGAGGAACX3G 53320 GGTTGCCCGG CAGTTCTGTT CGAGCTCGCC GGGCACGACO AGGAAGCCCT GGCGCAACGA 53380 1TCCGCTCGT TGCCTG1TGC GTCAGGGGGA ATAAGCGGCG TGTTGTCCIT GCIOGCGCTG 53440 GATCAATCGC CGTCCTCGCC GAACGCTGCT TTGCCGAATC GCGCGCTGAA CTCGTTGGTA 53500 CTCCTGCGAG CTCTGCGGGC CX5CGGATGTG TCGGCX^TCAT TGTGGTTGGC GACGTGTGGT 53560 GGTGTCGCGG TCGGGGATGT GCCGGTGAAC CCGGGGCAGG CGCTGGTGTG GGGACTGGGT 53620 CGCGTCGTCG GTCTGGAGCA TCCGGCCTGG TGGGGTGGCC TGGTCGACGT GCCGTGCTTG 53680
88 1237058 六、申請專利範圍 CTCGATGAGG ACGCTCGAGA ACGCTTGTCG GTCGTGTTGG CAGGTCTTGG CGAGGACGAG 53740 ATCGCGGTAC GTCCCGGTGG TGTGTTCGTG CGGCGGTTGG AACGCGCTGG TGCGGCGTCG 53800 GGTGCCGGGT CX3GTGTGGCG TCCTCGGGGG ACGGTGTTGG TGACGGGTGG TACGGGCGGT 53860 TTGGGGGCGC ATGTTGCCCG GTGGTTGGCG GGTGCCGGGG CTGAGCATGT GGTGTTGACC 53920 AGCCGTCGAG GCGCGGCGGC TCCGGGCGCT GGAGATTTGC GGGCGGAGCT GGAGGCGCTG 53980 GGCGCTCGGG TTTCGATCAC GGCCTGCGAC GTGGCCGATC GTGACX^CTTT GGCCGAAGTG 54040 TTGGCGACCA TTCCGGATGA TTGCCCGCTG ACCGCGGTGA TGCATGCGGC GGGGGTCGTT 54100 GAAGTCX3GCG ACX5TGGCGTC GATGTGTTTG ACCGACTTCG TTGGGGTGCT GTCX3GCGAAG 54160 GCAGGTGGTG CGGCGAATCT CGATGAGTTG CTCGCCGATG TCGAGCTGGA TGCCTTCX3TG 54220 CTGTTCTCAT CCGTCTCGGG TGTGTGGGGT GCTGGCGGGC AGGGCGCTTA TGCGGCX3GCG 54280 AATGCCTACT TGGATGCG1T GGCGCAGCAG CGTCGGGCAA GGGGGTTGGT GGGGACTGCG 54340 GTTGCGTGGG GCCCGTGGGC CGGTGACGGA ATGGCCGCAG GTGAAGGCGG TGCACAGCTG 54400 CGCCGGGCCG GCCTGGTGCC AAIX^GOTGCG GATCGGGCGT TGCTGGCACT TCAGGGCGCA 54460 TTGGATCGIO ACGAGACATC CCTGGTCGTG GCCGATATGG CGTGGGAGAG GTTCGCCCCG 54520 GTGTTCGCCA TGTCCCGTCG GCGTCCGCTG CTCGACGAGC TGCCCGAAGC ACAGCAGGCG 54580 TTGGCGGATG CGGAGAACAC CACTGATGCT GCGGACTCGG CCGTCCCGCT ACCGCX^3CTC 54640 GCGGGCATGG CAGCCGCCGA ACGCCGCCGC GCGATGCTGG ACCTGGTGCT GGCGGAGGCC 54700 TCGATTGTGT TGGGACACAA CGGGTCTGAC CCAGTTGGTC CCGACCGGGC GTTCCAGGAG 54760 CTCGGATTTG ATT03CTGAT GGCCGTCGAA CTGCGCAACA GGTTGGGCGA GGCAACAGGA 54820 TTGAGTCTGC CGGCCACGTT GATCTTCGAT TATCCGAGCC CATCCGCGCT GGCTGAGCAG 54880 CTGGTCGGCG AGCTGGTGGG AGCGCAGCCC GCGACCACCG TCGTGGCCX3G GGCCGATCCA 54940 GTGGATGATC CGGTTGTCGT GGTCGCGATG GGATGCCGGT ATCCGGGCGA CGTCTGCTCO 55000 CCCGAGGAGC TGTGGCAGCT GGTTTCTGCG GGACGTGATG CGGTATCX5AC GTTCCCCGTC 55060 GATCGGGGTT GGGACTGCAA CACOTTGTTC GACCCGGATC CGGATCX3GGC AGGCAGTACC 55120 TATGTGCGAG AAGGTGCCTT CCTGACCX3GT GCTGATCGGT TCGACGCCX3G GTTCTTCGGC 55180 ATCAGCCCTC GCGAGGCGCG CGCAATGGAT CCGCAGCAGA GGTTGrTGCT CGAAGIX3GCG 55240 TGGGAGGTIT TCGAACGAGC AGGAATCGCT CCGCTGTCGT TGCGGGGTAG CAGGACCGGT 55300 GTGTTCGCX3G GGACCAATGG GCAGGACCAC GGTGCGAAAG TGGCTGCCGC GCCX3GAGGCG 55360 GCGGGTCACC TCCTGACCGG AAACGCCGCG AGTGTCCTGG CCGGCCX3GCT TTCCTACACG 55420 TTCGGCCTTG AGGGGCCTGC GGTGGCGGTG GATACCGCGT GTTCGTCX3TC GTTGGTGGCG 55480 TTGCATTTGG CGTGCCAGTC GCTGCGTTCX3 GGTGAGTGTG ATATGGCGTT GGCAGGTGGT 55540 GTGACGGTGA TGTCGACACC CCJOGCTTTC CTCGAGTTCT CTCGTCAGCG CGGTTTGGCG 55600 CCAGATGGTC GGTGCAAGTC GTTTGCGGCC GCTGCGGATG GCACCGGGTG GGGTGAGGGT 55660 GCCGGCCTGG TGTIOCTGGA GCGGTTGTCG GATGCTCGTC GGAATGGTCA CCX3GGTGTTG 55720 GCCGTGGTTC GCGGGTCTGC GGTGAATCAG GATGGTGCGT CGAATGGCCT GACTGCGCCG 55780 AA1X3GTCCGT CGCAGCAGCG GGTGATTCGG CAGGCCCTCG CGAATGCGGG GCTGTCX3GCG 55840 TCCGATGTGG ATGTCGTGGA GGCGCACGGG ACCGGTACCG GGCTCGGGGA TCCGATCGAG 55900 GCGCAGGCGC TGATCGCGAC ATATGGGCAG GAGCGGGATC CTGAGCGGGC CCTGTGGCTG 55960 GGGTCGATCA AGTCCAACAT CGGCCACACG CAGGCGGCGG CCGGTGTGGC GGGGGTCATC 56020 AAGATGGTGC AGGCCATGCG GCACGGGGAG TTGCCTGCGA CGTTGCACGT GGACAAGCCC 56080 ACTCCACAGG TGGACTGGTC TGCCGGGGCC GTTCGGCTCC TCACCGGGAA CACGCCCTGG 56140
89 1237058 六、申請專利範圍 CCCGAGAGCG GCCGTCCTCG TCGAGCGGGG GTGTCGTCGT TCGGGATCAG CGGCACCAAC 56200 GCACACCTCA TCCTCGAACA ACCACCGTCG GAACCAGCX3G AGATCGACCA ATCX3GATCGG 56260 CGGGTCACTG CGCATCCAGC GGTGATCCCG TGGATGTTGT CGGCTAGGAG TCTCGCAGCG 56320 CTGCAGGCCC AAGCGGCTGC GCTGCAGGCC CGGCTGGACC GGGGTCCTGG COCOTCTCCO 56380 CTGGATTTGG GGTATTCACT CGCGACCACT CGTTCTGTGC TGGACGAACG CGCCGTCGTG 56440 TGGGGTGCCG ATCGGGAGGC ACTGCTGTCC AGGCTGGCAG CGCTCGCCGA TGGCCGGACX3 56500 GCGCCGGGGG TGATAACGGG CTCTGCGAAT TCCGGTGGCC GCATCGGATT CGTTTTTTCC 56560 GGTCAGGGCA GTCAGTGGCT GGGGATGGGA AAGGCGTTGT GCGCGGCTTT CCCGGCGTTC 56620 GCGGACGCCT TCGAGGAAGC CTGCGACGCG CTAAGCGCAC ACCTGGGCGC GGACGTTCGG 56680 GGTGTGCTGT TCGGTGCTGA TGAGCAGATG CTCGACCGGA CGCTGIXSGGC GCAGTCX3GGG 56740 ATCTTCGCGG TTCAAGTCGG CCTCCTGGGA TTGCTGAGGT CGTGGGGCGT GCGGCCGGCC 56800 GCGGTGCTGG GGCACTCGGT CGGCGAGTTG GCTGCGGCGC ACGCGGCTGG TGTG1TGTCC 56860 TTGCCGGACG CTGCACGGTT GGTTGCGGCT CGGGCCCACC TGATGCAGGC ATTGCCCACC 56920 GGCGGCGCAA TGCTCGCGGT CGCCACCAGC GAGGCGGCGG TCGGACCGCT GCTITCCGGG 56980 GTGTGCGATC GGGTCAGCAT CX5CTGCGATC AACGGCCCCG AGTCX3GTAGT GCTCTCCGGC 57040 GACCX3CGATG TGCTCGTGGA GCTCGCAGGC GAATTCGATG CCCGAGGGCT TAGGACCAAA 57100 TGGTTGCGGG TCTCCCATGC TTTCCACTCG CACCX3GATGG AACCXSATTCT GGACX3AGTAC 57160 GCGGAAACCG CCAGGTGCGT CGAGTTCGGT GAACCGGTGG TGCCGATCGT CTCCX3CCGCG 57220 ACCGGTGCGC TGGACACCAC CGGACTGATG TGCGCGGCCG ACTACTGGAC GCX3CCAAGTG 57280 CGTGATCCTG TCCGCTTCGG AGACGGTGTC CGGGCGCTCX5 TCGGCCAAGG CGTGGACACG 57340 ATCGTCGAGT TCGGCCCGGA CGGGGCGTTG TCX3GCCCTGG TCGAGCAGTG CITGGCCGGG 57400 TCCX5ACCAGG CTGGGAGGGT GGCGGCGATC CCX3CTGATGC GCAGGGACCG CGATGAGGTC 57460 GAGACCGCGG TGGCGGCCCT GGCGCACGTG CACGTCCGCG GTGGTGCX3GT GGACTGGTCG 57520 GCTTGCTTCG CCGGCACCGG CGCCCGCACC GTCGAGTTGC CCACCTACGC CITCCAACGC 57580 CAGCGGTACT GGCTGGCCGG GCAAGCGGAC GGGCGCGGCG GCGATGTGGT TGCCGACCCX5 57640 GTCGhCGCGC GCTTCTGGGA GTTGGTCGAG CGCGCCGATC CGGAACCGTT GGTGGATGAA 57700 CTCTGCATCG ACCGGGACCA GCCCTTCCGG GAGGTGCTGC CCGTTCTGGC TTCCTGGCX3C 57760 GAGAAACAAC GCCAGGAGGC CCTCGCGGAT TCCTGGCGCT ACCAGGTGCG CTGGAGGTCC 57820 GTCGAGGTGC CGTCCX5CAGC CGCCCTCCGG GGCGTGTGGC TGGTGGTGCT TCCAGCTGAC 57880 GTGCCCCX5AG ATCAACCGGC GGTCGTCATC GACGCGCTGA TCGCX3CGCX3G CGCCGAGGTC 57940 GGGGTCCTGG AATTGACCGA GCAGGACCTC CAACXSCAGTG CGCTTGTGGA CAAGGTGCGC 58000 GCCGTCATTG CGGACCGCAC CGAGGTGACG GGTGTGTTGT CTCTGTTGGC GATGGACGGC 58060 ATGCCCTGCG CGGCGCATCC GCACCTGTCC CGTGGTGTCX3 CCGCTACCX5T GATCCTGACG 58120 CAGGTGTTGG GCGATGCGGG TGTTTCCGCC CCGCTGTGGC TGGCCACGAC CGGTGGCGTC 58180 GAGGCCGGGA CCGAGGACGG TCCGGCCGAT CCGGACCACG GCTTGATCTG GGGGCTCGGC 58240 AGGGTCGTCG GCCTTGAACA TCCGCAGTGG TGGGGTGGCC TGATCX3ACCT TCCGGAGACA 58300 CTGGAC!GAGA COTCCCGGAA CGGGTTGGTG GCCGCACTCG CCX3GGACGGC GGCCGAAGAT 58360 CAGCTCGCCX5 TGCGTTCATC CGGGTTGTTC GTTCGCAGAG TGGTGCGCGC AGCGCGGAAC 58420 CCCCGGTCAG AGACATGGCG TAGCCGGGGA ACGGTCCTCA TCACGGGCGG AACAGGCX^CG 58480 CTCGGTGCCG AGGTCGCACG ATGGCTGGCC CGGCGGGGAG CTGAGCACCT GGTGTTGATC 58540 AGTCGCCGCG GCCCGGAAGC TCCCGGCGCA GCGGACCTAG GGGCCGAGCT GACTGAACTC 58600
90 1237058 六、申請專利範圍 GGCGTGAAAG TCACAGTCTT GGCCTGCGAT GTGACGGACC GCGACGAGCT GGCGGCGGTG 58660 CTGGCGGCCG TTCCCACGGA GTATCCGCTG TCGGCGGTCO TGCACACCX3C CGGCGTCGGG 58720 ACGCCTGCGA ACCTGGCCGA GACGACCTTG GCGCAGTTCG CCGACGTCTT GTCGGCCAAG 58780 GTCGTCGGCG CGGCGAACCT GGACCGGCTG CTTGGCGGGC AACCGTTGGA CGCCTTCGIO 58840 CTGTTCTCCT CGATCTCGGG AGTITGGGGA GCCGGCGGCC AAGGAGCCTA TTCGGCCGCC 58900 AATOCGTATC TCGATGCCCT TGCCGAGCGC CGACGGGCTT GCGGGCGGCC GGCGACGTGC 58960 ATCGCCTGGG GTCCGTGGGC GGGTGCGGGC ATGGCCGTTC AGGAAGGTAA CGAGGCGCAT 59020 CTCCGCCXSAA GGGGCCTGGT ACCGATGGAA CCX3CAGTCGG CCCTCTTCGC GCTGCAACAG 59080 GCCCTGTCCC AACGAGAAAC CGCCATCACC GTCGCAGATG TGGACTGGGA GCGATTCGCC 59140 GCCTCITTCA CCGCGGCCCG CCCGCGACCA CTGTTGGAAG AGATCGTGGA TCTACGGCCC 59200 GACACCGAGA CCGAGGAGAA GCACGGTGCC GGCGAGCTGG GGCAGCAGCT GGCCGCACTG 59260 CCGCCCGCTG AGCGCGGACA CCTGCTGCTG GAGGTGGTGC TGGCGGAAAC CGCCAGCACC 59320 CTGGGGCACG ATTCGGCGGA GGCTGTGCAA CCCGATCGGA CCTTCGCCGA ACTGGGCTTC 59380 GATTCGCTGA CCGCGGTAGA GCTGCGCAAC AGGTTGAACG CGGTGACCGG GCTTCGCCTG 59440 CCGCCGACGC TGGTTTTCGA CCACCCGAC!G CCGCTGGCGT TGTCCGAACA GTTGGTTCCG 59500 GCCCTGGTCG CGGAGCCGGA CAACGGCATC GAATCGCTGC TCGCCX3AGCT CGACAGGCTG 59560 GATACCACGT TGGCGCAAGG GCCTTCGATC CCACTGGAAG ACCAGGCCAA GGTGGCGGAG 59620 CGCTTGCACG CACTCCTCGC CAAGTGGGAC GGGGCGCGTG ACGGCACGGC CAGAGCGACG 59680 TCACCCCAAT CGCTGACGGC GGCCACGGAC GACGAAATCT TCGACCTCAT CGACCGGAAG 59740 TTCCGGCGCT GACCGCCCTT TCCTCGCCTC AGCTCCCCTG ATTACTGGAA CGGTGTATTT 59800 CGATGGCCAA TGAAGAAAAG CTCCGCGAGT ACCTCAAGCG TGTCGTCGTC GAACTGGAAG 59860 AGGCGCACX3A ACGCCTGCAC GAGTTGGAGC GCCAGGAGCA CGACCCCATC GCX3ATCGTGT 59920 CGATGGGATG TCGTTATCCC GGTGGCGTCT CCACTCCGGA GGAGCTGTGG COACTGGTCX^ 59980 TCGACGGAGG AGACGCGATC GCGAACTTCC CCGAAGACCG TGGCTGGAAT CTGGACGAGC 60040 TGTTCGATCC TGATCCGGGC CGAGCCGGGA CCTCCTACGT CCX5CGAGGGT GGTTTCCTGC 60100 GCGGGGTCGC GGACTTCGAT GCCX3GGCTCT TCGGGATCAG TCCGCGOGAG GCACAGGCGA 60160 TGGACCCGCA ACAGCGGITG CTGCTGGAGA TCTCGTGGGA GGTGTTCX5AG CGCGCCGGCA 60220 TTGACCCGTT TTCTITGCGG GGTACCAAGA CCGGTGTGTT CGCGGGCCTG ATCTACCACG 60280 ACTACGCGTC GCGGTTTCGC AAGACCCCCG CGGAGTTCGA GGGTTACrTC GCCACCGGCA 60340 ACGCGGGCAG CGTCGCATCC GGCCGGGTGG CTTACACCTT CGGGTTAGAG GGCCCGGCGG 60400 TCACCGTGGA CACCGCCTGC TCGTCGTCCC TGGTGGCGCT GCACCTGGCC TGCCAGTCCC 60460 TGCGGCTGGG CGAATGCX5AC CTCGCCCTGG CCGGTGGCAT TTCGGTGATG GCCACX3CCGG 60520 GAGCCTTCGT CGAGTTCAGC CGGCAACGCG CACTCGCCTC GGATGGCCX3G TGCAAGCCCT 60580 TCGCGGATGC CGCCGACGGC AC03GCTGGG GCGAGGGCGC CGGAATGCTG CIOCTGGAAC 60640 GGCTGTCGGA CGCACGACGA AACGGCCACC CGGTGCTGGC GGCGGTGGTC GGTTCCGCGA 60700 TCAACCAGGA CGGGACGTCC AACGGCCTGA CCGCGCCCAG CGGTCCCGCA CAGCAGCGAG β〇76〇 TGATCCGCCA AGCCCTGGCG AACGCCGGGT TGTCGCCCGC CGAGGTCGAT GTGGTCGAGG 60820 CXXACGGCAC GGGCACGGCC TTGGGCGACC CGATCGAGGC GCAGGCCCTG ATCGCCACCT 60880 ACGGGGCGAA CCGGTCGGCG GATCATCCGC TGCTGCTGGG TTCCCTCAAG TCGAACATCG 60940 GCCACACCCA GGCTGCCGCC GGTGTGGCCG GGGTGATCAA GTCGGTCCTG GCCATCAGGC 61000 ACCGGGAGAT GCCCCGCAGC CTGCACATCG ACCAGCCATC GCAGCACGTG GACTGGTCGG 61060
1237058 六、申請專利範圍 CGGGCGCGGT GCGGCTGCTC ACGGACAGCG TTGACTGGCC GGATCTCX3GC AGGCCGCGCC 61120 GAGCAGGGGT GTCCTCGTTC GGCATGAGCG GTACCAACGC ACACCTGATC GTCGAGGAAG 61180 TATCCGACGA GCCGGTCTCG GGCAGTACCG AGCCGACCGG GGCATTTCCC TGGCCGCTGT 61240 CCGGCAAGAC GGAGACGGCA TTGCGCGAGC AGGCTGCCGA GTTGCTCTCC GTAGTGACCG 61300 AGCACCCGGA GCCGGGACTG GGGGACGTCG GGTACTCGCT GGCCACCGGT CGCGCTGCGA 61360 TGGAGCACCG GGCTGTCGTG GTTGCCGACG ATCGGGACTC TTTCGTCGCC GGACTGACGG 61420 CGTTGGCTGC GGGCGTTCCG GCAGCCAACG TGGTGCAGGG CGCGGCCGAC TGCAAGGGAA 61480 AGGTCGCGTT CGTGTTCCCC GGCCAGGGCT CGCATTGGCA GGGGATGGCG AGGGAACTGT 61540 CCGAATCCTC GCCGGTGTTC CGGCGGAAGC TGGCGGAATG CGCGGCGGCT ACGGCCCCTT 61600 ACGTGGACTG GTCGCTGCTC GGCGTCCTTC GCGGTGATCC CGATGCACCC GCGCTGGATC 61660 GCGACGACGT GATTCAGCTC GCGCTGTTCG CCATGATGGT GTCGCTGGCC GAACTGTGGC 61720 GTTCGTGCGG AGTGGAGCCC GCCGCGGTGG TCGGTCATTC CCAGGGCGAG ATCGCCGCCG 61780 CCCATGTGGC AGGCGCITTG TCCTTGACTG ATGCGGTGCG CATCATCGCT GCCCGCTGCG 61840 ATGCGGTGTC GGCGCTGACC GGGAAGGGAG GCATGCTCGC GATTGCCTTG CCGGAAAGCG 61900 CGGTGGTGAA GCGAATCGCA GGCCTGCCGG AGCTGACCGT TGCGGCGGTC AACGGACCCG 61960 GCTCCACTGT CGTTTCCGGC GAACCGTCGG CTCTGGAGCG TCTGCAGACC GAACTGACCG 62020 CGGAAAACGT GCAGACCCGG CGGGTGGGAA TTGATTACGC CTCGCATTCG CCGCAGATCG 62080 CGCAGGTCCA GGGCCGGCIT CTGGACCGGC TGGGCGAAGT CGGGTCCGAA CCTCCTGAGA 62140 TCGdTTCTA CTCGACGGTC ACCGGCGAGC GGACGGACAC CGGCCGACTC GACGCCGACT 62200 ACTGGTACCA GAACCTTCGG CAGCCCGTCC GCTTCCAGCA GACCGTCGCC CGGATGGCAG 62260 ATCAGGGCTA TCGGTTCTTC GTCGAGGTGA GCCCGCACCC GCTGCTCACC GCCGGAATCC 62320 AGGAAACGCT GGAAGCCGCG GACGCGGGCG GGGTGGTGGT CGGTTCGCTG CGGCGTGGCG 62380 AGGGCGGCTC CCGGCGCTGG CTGACTTCGC TGGCCGAGTG CCAGGTGCGC GGACTGCCGG 62440 TGAATTGGGA ACAGGTATTC CTCAACACCG GAGCCCGACG CGTGCCGCTG CCGACCTACC 62500 CGTTCCAGCG GCAGCGGTAC TGGTTGGAGT CCGCCGAGTA CGACGCGGGC GATCTCGGTT 62560 CGGTGGGCTT GCTCTCCGCC GAGCATCCCC TGCTCGGGGC TGCGGTGACG CTGGCCGATG 62620 CGGGCGGGTT CCTGCTGACC GGCAAGCTGT CGGTCAAGAC CCAGCCCTGG TTGGCCGACC 62680 ACGTGGTCGG CGGGGCGATC CTGCTGCCCG GCACCGCGTT CGTGGAAATG CTGATACGCG 62740 CCGCGGACCA GGTCGGGTGC GATCTGATCG AGGAGTTGTC CCTGACGACT CCGCTGGTTT 62800 TGCCCGCGAC CGGTGCGGTG CAGGTGCAGA TCGCGGTTGG CGGTCCGGAC GAGGCCGGGC 62860 GCCGCTCGGT CCGCGTGCAT TCCTGTCGAG ACGACGCCGT GCCGCAGGAC TCGTGGACCT 62920 GCCACGCGAC CGGCACG1TG ACCTCCAGCG ATCACCAGGA CGCCGGCCAG GGCCCCGATG 62980 GGATTTGGCC GCCCAACGAT GCTGTCGCGG TTCCGCTGGA CAGCTTCTAC GCCCGCGCAG 63040 CTGAGCGGGG CTTCGATTTC GGCCCGGCGT TCCAGGGGTT GCAGGCGGCT TGGAAGCGCG 63100 GAGACGAGAT CTTCGCCGAG GTCGGCCTGC CCACCGCACA CCGCGAAGAC GCCGGCAGGT 63160 TCGGAATCCA CCCTGCTCTG CTGGATGCGG CACTGCAGGC GCTGGGCGCA GCCGAAGAGG 63220 ATCCGGACGA GGGATGGCTC CCGTTCGCGT GGCAAGCTGT GTCCCTCAAA GCGACGGGCG 63280 CACTTTCCCT TCGGGTGCAC CTCGTTCCGG CGGGCGCGAA TGCGGTGTCG GTGTTCACGA 63340 CCGACACGAC TGGCCAAGCC GTGCTCTCCA TCGATTCGCT GGTGCTGCGC CAGATTTCGG 63400 ACAAGCAGTT GGCAGCGGCC CGTGCGATGG AACACGAGTC CCTGTTCCGG GTCGACTGGA 63460 AGCGAATCTC GCCCGGCGCT GCCAAGCCGG TCTCCTGGGC AGTGATCGGC AATGACGAAC 63520
1237058 六、申請專利範圍 TCGCCCGAGC CTGCGGCTCG GCACTTGGCA CGGAACTCCA CCCCGACCTG ACCGGGTTGG CTGACCCGCC CCCGGACGTC GTGGTGGTGC CATGCGGTGC GTCTCGCCAG GACTTGGACO TTGCTTCCGA GGCACGTGCC GCGACACAAC GCATGCTTGA CCTGATCCAG GATTGGTTGG CGGCGGCGCG ATTCGCCGGA TCTCGCCTGG TGGTTGTGAC GTGTGGTGCG GCX5TCGACAG GTCCCGCCGA GGGTGTTTCC GACCTGGTGC ATGCTGCGTC GTGGGGTTTG TTGCGTTCX3G CGCAGTCGGA GAACCCGGAC CGATTCGTGT TGGTCGATGT GGACGGAACC GCCGAATCAT GGCGTGCGCT CGCGGCGGCC GTGCX5TTCCG GAGAACCX3CA GCTGGCGTTG CGCGCCGGTG AAGTCCX3GGT GCCTCX5CCTG GCGCJGATGTG TTGCCGCCGA GGACAGCCGG ATCCCAGTGC CCGGTGCX3GA TGGGACX3GTG TTGATTTCCG GCGGTACX3GG CCTGCTGGGC GGG1TGGTTG CCCGGCATTT GGTGGCGGAG CGCGGTGTCC GCCGCCTGGT GCTCX5CGGGG CGACGCGGCT GGAGCGCCCC CGGGGTCACC GACCTGGTGG ATGAGTTGGT GGGCCTGGGA GCTGCGGTCG AGGTGGCGAG CTGCGATGTC GGGGhTCGGG CCCAGTTGGA CCX3GCTGCTG ACGACGATCT CX3GCAGAGTT CCCGCTGCGC GGAGTGGTGC ATGCX3GCCGG GGCACTTGCC GACXSGGGTCO TCGAGTCGCT GACACCAGAG CACX3TGGCAA AGGIX3TTCGG CCCGAAGGCC GCCGGTGCGT GGCACCTGCA CGAGTTGACT CITGATCTGG ATCTCTCGTT CTTCGTGCTC TTCTCCTCGT TCTCCGGCGT GGOGGGGGCT GCGGGTCAGG GAAACTACGC GGCX3GCX3AAC GCG1TCCTGG ACGGCCTGGC TCAGCACCGG CGGACGGCGG GGCTGCCTGC GGTGTCX5CTG GCITGGGGCT TGTGGGAGCA GCCCAGCX3GG ATGACCX3GAG CGCTCX3ATGC GGCGGGCCOT AGCCGCATTG CGCGCACCAA TCCX3CCGATG TCCGCGCCGG ACJGGGTTGCG GCTGTTCGAG ATGGCGTITC GCGTTCCGGG CGAATCXX^TT CTGGTTCCGG TCCACGTCGA CCTGAACGCC CTGCX3CGCTG ATGCGGCCGA CGGCGGTGTG CCTGCGTTGT TGCGCGACCT GGTGCCAGCG CCCGTGCGGC GGAGCGCGGT CAACGAGTCG GCGGACX3TCA ACGGTCTGGT TGGTCGGCTG CGGAGGCTGC CGGACCTGGA TCAGGAAACC CAGCTGTTGG GTTTGGTGCG CGAGCATGTT TCGGCGGTGC TGGGGCATTC GGGTGCGGTC GAGGTCGGGG CCGATCGTGC TTTCCGGGAT TTGGGTTTTG ATTCGTTGTC CGGTGTGGAG TTTCGGAACC GGCTTGGCGG GGTGCTGGGC GTTCGGTTGC CGGCTACTGC GGTGTTCGAC TATCCGACAC CGCGGGCGTT GGTTCGGTTC TTGCTCGACA AACTGATTGG TGGCGTGGAG GCTCCGACTC CCGCACCGGC GGCTGTGGCG GCGGTGACTG CTGACGATCC CGTTGTGATC GTGGGGATGG GCTGTCGTTA TCCGGGTGGG GTGTCCTCXX CGGAGGAGCT TTGGCGTTTG GTGGCCGGGG GCITGGATGC GGTGGCGGAG TTCCCGGACG ATCGTGGCTG GGATCAGGCO GGG1TGTTCG ATCCGGATCC CGATCGTCTT GGGACCTCOT ATGTGTGTGA GGGTGGCTTC CTGCGAGAIO CGGCAGAGTT CGATGCCGGT TTCTTCGGGA TTTCCCCGCG TGAGGCGTTG GCGATGGATC CGCAGCAGCG GTTGCTGCTG GAAGTCGCTT GGGAAACCGT GGAGCGGGCG GGGA1TGATC CGCTTTCGTT GCGGGGGAGC CGGACCGGCG TGTTCGCGGG GCTGATGCAC CACGACTACG GCGCGCGGTT CATCACGAGG GCGCCGGhGG GTTTCGAGGG TTATCTAGGT AATGGCAGCG CGGGAGGCGT GTTTTCGGGT CGGGTTGCJGT ATTCGTTTGG TTTCGAGGGT CCTGCGGTGA CGGTGGATAC GGCGTGTTCG TCGTCGTTGG TGGCGCTGCA CCTGGCGGGT CAAGGACTGC GGTCTGGTGA GTGTGATCTG GCTCTTGCGG GTGGIOTGAC GGTGATGGCC ACX5CCGGGGA TGITCJGTGGA GTTTTCGCGT CAACGGGGCT TGGCGGCGGA TGGGCGGTGC AAGTCGTITG CGGCX3GCTGC GGATGGCACC GGTTGGGGAG AAGGCGCGGG CTTGGTGTTG TTGGAGCGGC TGTCGGATGC CCGGCGCAAC GGGCACGCGG TTCTGGCGGT CGTGCGGGGT AGCGCGGTGA ATCAGGATGG TGCGTCGAAT GGTTTGACGG 63580 63640 63700 63760 63820 63880 63940 64000 64060 64120 64180 64240 64300 64360 64420 64480 64540 64600 64660 64720 64780 64840 64900 64960 65020 65080 65140 65200 65260 65320 65380 65440 65500 65560 65620 65680 65740 65800 65860 65920 65980 93 1237058 六、申請專利範圍 CGCCGAATGG GCCCTCGCAG CAGCGGGTGA TCACGCAGGC GTTGGCGAGT GCTGGTTTGT 66040 CGGTGTCTGA TGTGGACGCC GTGGAQGCGC ATGGGACTGG AACCAGGCTT GGTGATCCGA 66100 TTGAGGCGCA GGCTCTGATT GCCACTTACG GGCAGGGGCG GGATAGCGAT CGGCCGTTGT 66160 GGTTGGGGTC GGTGAAGTCG AATATTGGTC ATACGCAGGC GGCGGCGGGT GTCX3CTGGIX3 66220 TGATCAAGAT GGTGATGGCG ATGCGGCACG GGCAGCTGCC CGCX^CGTTG CATGTGGAIO 66280 AACCTACGTC GGAAGTGGAT TGGTCGGCGG GGGATGTCCA GCTCCTCACG GAGAACACCC 66340 CCTGGCCCGG CAACAGCCAT CCTCGGCGGG TGGGCGTGTC GTCGTTCGGG ATCAGCGGCA 66400 CCAACGCACA CGTCATCCTC GAACAAGCCT CGAAAACACC AGAC!GAGACT GCGGACAAGA 66460 GCGGTCCCGA TTCGGAATCG ACCGTGGACC TTCCAGCGGT CCCGTTGATC GTGTCGGGGA 66520 GAACACCGGC AGCGCTCAGC GCTCAGGCGA GCGCATTGTT GTCCTAITTG GGTGAGCGTG 66580 GCGATATTTC CACGCTGGAT GCGGCGTTTT CGTTGGCTTC CTCCCGGGCC GCGTTGGAGG 66640 AGCGGGCGGT GGTGCTGGGA GCGGACCGCG AAACGTTGTT GTCCGGGTTG GAAGCX3CTGG 66700 CTTCCGGTCG CGAGGCTTCT GGGGTGGTGT CGGGATCCCC GGTCTCTGGC GGGGTTGGGT 66760 TCGTG1TCGC CGGTCAGGGC GGACAGTGGT TGGGGATGGG CCX3GGGGCTC TACTCGGITT 66820 TTCCGGTGTT CGCTGACGCG TTTGACGAAG CATGTGCCGG ACTGGACGCG CATCTGGGGC 66880 AGGACGTGGG GGTCCGGGAT GTGGTGTITG GTTCCGACGG GTCCTTGTTG GATCX3GACX3C 66940 TGTGGGCCCA GTCX3GGTTTG TTCGCGTTGC AGGTTGGTTT GCTGAGCCTG CTGGGTTCX3T 67000 GGGGTGTCCG GCCGGGTGTG GTGCTGGGCC ATTCGGTCX3G CGAGTTCGCG GCX3GCGGTTG 67060 CGGCGGGAGT GITGTCGTTG CCGGATGCGG CTCGGATGGT GGCGGGTCGT GCCCGGTTGA 67120 TGCAGGCGTT GCCTTCTGGC GGTGCCATGT TGGCGGTGGC TGCTGGTGAG GAGCAGCTGC 67180 GGCCGTTGTT GGCCXSATCGG GTTGATGGTG CGGGTATCGC CGCGGTCAAC GCTCCTGAGT 67240 CGGTGGTGCT CTCCGGCX3AT CGGGAGGTGC TTGACGACAT CGCCGGCGCG CTGGATGGGC 67300 AAGGGATTCG GTGGCX3GCGG TTGCGGGTTT CGCATGCGTT TCATTCOTAT CGGATGGACC 67360 CGATGTTGCA GGAGTTCGCC GAAATCGCAC GCAGCGTGGA CTACCGGCGT GGCGACCTAC 67420 CGGTCGTGTC GACGTTGACG GGTGAGCTCG ACACCGCAGG TGTGATGGCT ACGCCGGAGT 67480 ATTGGGTGCG TCAGGTTCGA GAGCCCGTCC GCTTCGCCGA CGGCGTCCGG GTGCTCGCGC 67540 AGCAAGGGGT CGCCACGATC TTCGAACTCG GCCCTGATGC GACGCTGTCG GCCCTGATTC 67600 CCGATTGTCA TTCGTGGGCT GATCAGGCCA TGCCGATTCC GATGCTGCGT AAAGACCGTA 67660 CGGAAACCGA AACTGTGGTC GCCGCGGTGG CGCGGGCGCA CACGCGTGGT GTTCCGGTCG 67720 AATGGTCGGC GTATTTCGCC GGCACCGGGG CACGGCGGGT CGAGTTGCCG ACGTATGCCT 67780 TCCAGCGGCA GCGGTACTGG CTGGAAACAT CGGATTACGG CGATGTGACG GGTATCX3GCC 67840 TGGCTGCGGC GGAGCATCCG TTGCTGGGGG CCGTGGTTGC GCTGGCCGAT GGTGATGGGA 67900 TGGTGCTGAC CGGCCGGTTG TCGGTGGGGA CGCATCCGTG GCTGGCCCAG CATCGCGTGC 67960 TGGGCGAGGT CGTCGTCCCC GGCACCGCCA TCCTGGAGAT GGCCCTGCAC GCAGGGGCGC 68020 GTCTCGGCTG TGACCGGGTG GAAGAGCTCA CCCTGGAAAC ACCGCTGGTG GTCCCCGAAC 68080 GCGCGGCGGG TGCCGGTAGT CGTGGCCCTG CGGGAGGGAC C^CAGTTTCA ATTGAAACTG 68140 CGGAAGAACG TGTGCGGACG AACGACGCCA TCGAAATCCA GCTGCTGGTG AACGCACCCG 68200 ACGAAGGCGG TCGGCGAAGG GTGTCGCTGT ATTCCCX^CCC GGCCGGTGGG TCGAGAGGTG 68260 GGGGTTGGAC GCGCCACGCC ACCGGCGAAC TCGTCGTCGG CACCACCGGT GGTAGGGCGG 68320 TTCCTGATTC GTCGGCTGAG GGTGCCGAGT CGATTGCTCT CGATGAGTTC TACGTCGCTC 68380 TGGCCGGAAA CGGGTTCGAG TACGGGCCGT TGTTCCAGGG GCTTCAGGCG GCATGGCGTC 68440
1237058 六、申請專利範圍 GTGGTGACGA GGTTCTCGCC GAAATCGCCC CGCCGGCCGA GGCCGATGCG ATGGCX5TCGG 68500 GATACCTGCT CGACCCAGCG TTGCTGGATG CCGCOCTGCA GGCGTCCGCG CTCGGCGACC 68560 GCCCGGAGCA AGGCGGCGCG TGGCTGCCGT TCTCATTCAC CGGCGTCGAA CTTTCCGCTC 68620 CGGCAGGGAC GATCAGCAGG GTGCGGCTGG AGACCAGGCG ACCCGACGCG ATATCX3GTGG 68680 CCGTGATGGA TGAGAGTGGG CGGTTGCTCG CCTCGATCGA TTCTCTCAGG CTACGAAGCG β8740 TGTCGTCGGG ACAGCTGGCG AATCGGGACG CTGTCCGCGA CGCGCTGTTC GAGGTGACCT 68800 GGGAGCCGGT GGCGACGCAG TCGACGGAAC CGGGTCGCTG GGCCCTCCTT GGTGATACTG 68860 CCTGCGGTAA AGACGATCTC ATCAAACTCG CAACGGATTC CGCCGACCGC TGCGCGGATC 68920 TGGCGGCGCT AGCCGAGAAA CTTGATTCCA GCGCGCTGGT TCCTGATGTC GTGGTCTACT 68980 GCGCCGGAGA ACAGGCGGAT CCCGGCACCO GCGCAGCCGC ACTTGCGGAG ACCCAGCAGA 69040 CGTTGGCTCT GCTCCAAGCG TGGTTGGCTG AGCCGCGGTT GGCCGAGGCA CGTCTGGTGG 69100 TGGTGACGTG TGCAGCGGTG ACGACGGCTC CGAGTGACGG TGCATCAGAG CTGGCACATG 69160 CGCCGTTGTG GGGGTTGTTG CGTGCCGCGC AGGTGGAGAA CCCGGGGCAG TTTGTGCTGG 69220 CGGACGTCGA CGGAACCGCC GAATCGTGGC GTGCGTTGCC GAGTGCGTTG GGCTCGATGG 69280 AACCGCAGTT GGCCCTGCX3G AAGGGCGCX3G TGCGAGCGCC CCGCTTGGCT TCGGTC!GCCG 69340 GGCAGATCGA CX3TGCCCGCG GTTGTGGCGG ATCCCGACCG AACCGTGCTG ATTTCGGGCG 69400 GCACGGGCCT GTTGGGGGGC GCGGTTGCCC GCCACCTGGT GACCGAACGC GGTGTCCGCC 69460 GATTGGTGTT GACX3GGCCGT CGTGGCTGGG AIXSCTCCTGG AATCACCGAG TTGGTGGGTG 69520 AGCTGAACGG CCTCGGTGCC GTGGTCGACO TGGTGGCGTG CGACGTCGCG GATCOTGCTG 69580 ATCTGGAGTC GTTGCTGGCG GCGGTCCCGG CGGAATITCC GTTGTGCGGC GTGGTGCATG 69640 CCGCGGGGGC GCTGGCCGAC GGGGTGATCG AGTCGTTGTC ACCGGACGAC GTGGGAGCGG 69700 TGTTCGGCCC GAAGGCGGCG GGGGCGTGGA ATCTGCACGA GCTGACTCGT GATACGGACC 69760 TGTCGTTCTT CGCGTTGTTC TCCTCGCITr CCGGTGTTGC CGGCGCTCCT GGTCAGGGCA 69820 ATTATGCGGC GGCGAACGCG TTCCTGGACG CATTGGCGCA TTACCGGCGG TCACAGGGAC 69880 TGCCTGCGGT GTCX3CTGGCC TGGGGCCTGT GGGAGCAGCC GAGCGGGATG ACGGAGACGC 69940 TCAGCGAGGT CGACCGGAGC AGGATCGCGC GCGCCAACCC GCCGTTGTCC ACCAAGGAGG 70000 GATTGCGGCT GTTCGATGCC GGGCTGGCGC T^GGACCGGGC AGCGGTAGTT CCGGCX3AAGT 70060 TGGACAGGAC TTTCCTGGCC GAGCAGGCGC GGTCGGGCTC GCTGCCCGCA TTG1TGACGG 70120 CACTGGTACC CCCCATCCGT CGTAATAGGC GGGCTAGCGG AACCX5AGCTC GCGGACGAGG 70180 GGACCCTGCT CX3GGGTGGTG CGGGAGCATG CCGCGGCCX3T GCTGGGGTAT TCX3AGCGCGG 70240 CTGACGTCGG GGTCGAGCGC GCTTTCCGGG ATCTGGGTTT TGATTCGTTG TCTGGTGTGG 70300 AGTTGCGGAA CCGCCTTGCC GGGGTGCTGG GGGTGCGGTT GCCGGCGACT GCX3GTGTTCG 70360 ACTATCCGAC GCCGAGGGCG CTGGCCCGGT TCCTGCACCA GGAACTGGCA GACGAGATCG 70420 CTACGACGCC AGCGCCGGTG ACGACGACCA GGGCACCGGT CGCCGAAGAC GATCTCGTCG 70480 CGATAGTCGG GATGGGATGC CGTTTTCCCG GTCAGGTGTC CTCGCCX3GAG GAGCTCTGGC 70540 GTTTGGTGGC CGGGGGCGTG GATGCGGTCG CGGACTTCCC AGCCGATCGC GGCTGGGATC 70600 TGGCAGGCTT GITCGATCCG GACCCGGAAC GGGCTGGGAA GACCTACGTG CGGGAAGGGG 70660 CCTTCCTCAC CGACGCCGAT CGGTTCGATG CX3GGTTTCTT CGGGATTTCC CCGCGTGAGG 70720 CGTTGGCGAT GGATCCGCAG CAACGGCTGT IX3CTGGAGCT GTCCTGGGAG GCCATTGAAC 70780 GGGCAGGGAT CGATCCGGGT TCGCTGAGGG GGAGTCGGAC CGGTGTGTTC GCGGGGCTGA 70840 TGTACCACGA CTATGGCGCC CGGTTCGCCA GCCGAGCCCC GGAAGGTTTC GAGGGGTATC 70900
1237058 六、申請專利範圍 TCGGCAATGG CAGTGCTGGG AGTGTCGCGT CGGGCCX3GAT TGCGTACTCG TTTGGTTTCG 70960 AGGGTCCTGC GGTGACGGTG GATACTGCGT GTTCGTCGTC GTTGGTGGCG TO^TTTGG 71020 CGGGTCAGTC GTTGCGTTCC GGCGAATGCG ATCTCX5CCCT TGCCGGTGGT GTGACGGTGA 71080 TGTCGACGCC CGGGACGTTT GTGGAATTCT CCCGTCAGCG GGGCCTGGCA CCX3GACX3GGC 71140 GGTGCAAGTC GTTCGCGGAG AGCGCGGACG GTACCX3GTTG GGGTGAGGGT GCTGGTTTGG 71200 TGTTGTTGGA GCGGTTGTCG GATGCTCX3GC GGANTGGGCA TCGGGTGTTG GCGGTGGTTC 71260 GTGGGTCGGC GGTGAATCAG GATGGTGCGT CGAATGGCTT GACCGCGCCX5 AATGGTCCCT 71320 CGCAGCAGCG GGTCATCCAG CAGGCGTTGG CGAGTGCGGG TCTGTCGGTG TCCGATGTGG 71380 ATGCCGTGGA GGCGGATGGG ACCGGGACCA GGITGGGTGA TCCGATTGAG GCGCAGGCTC 71440 TGATTGCTAC GTATGGGCGC GATCGTGATC CCGGTCGGCC GTTGTGGTTG GGGTCGGTGA 71500 AGTCCAACAT CGGTCATACG CAGGCGGCGG CX3GGTGTTGC CGGTGTGATC AAGATGGTGA 71560 TGGCGATGCG GGACGGGGAA CITCCGCGCA CGCTGCACGT GGATGCACCC TCCTCGCAGG 71620 TGGATTGGTC GGCGGGGAGG GTCCAGCTCC TGACX3GAGAA CACGCCCTGG CCCGACAGTG 71680 GTCGCCCCTG TCGGGTGGGG GTGTCGTCGT TCX3GGATCAG CX3GCACCAAC GCX5CACGTCA 71740 TCCTGGAACA GTCCACGGGG CAGATGGATC AGGCAGCGGh GCCGGATTCG AGTCCTGTTC 71800 TGGATGTTCC GGTGGTGCCO TGGGTGGTGT CGGGCAAAAC ACCCX3AAGCG CTATCCGCCC 71860 AGGCGGCAAC GTTGGCGACC TATTTGGACC AAAATGTTGA TGTCTCCCCT CTGGACGTTG 71920 GGATTTCGCT TGCGGTGACC CGTTCGGCGC TGGAIX3AGCG GGCGGTGGTG CTGGGGTCGG 71980 ATCGTGACAC GTTGTTGTCT GGCCTGAATG O^GGCTGC CGGTCATGAG GCTGCTGGCG 72040 TGGTTACGGG ACCTGTCGGG ATTGGTGGCC GGACCGGG1T TGTGTTCGCC GGTCAAGGCO 72100 GTCAGTGGTT GGGGATGGGC CGCCGGTTGT ACTCGGAGTT TCCGGCGTTC GCCX3GTGCTT 72160 TCGACGAAGC ATGCGCCGAG CTCX5ATGCGA ACCTGGGGAG GGAAGTCGGG GTTCGGGAIO 72220 TGGTGTTCGG CTCCGACGAG TCC^CTGCTGG ATCGGACTTT GTGGGC!GCAG TCGGGTITGT 72280 TCGCGTTGCA GGTCGGTCTC TGGGAA1TGT TGGGTACGTG GGGTGTTCGG CCCAGCGTAG 72340 TGCTGGGGCA TTCGGTCGGG GAGCTAGCCX5 CGGCGTTCGC CGCAGGTGTG CTGTCGATGG 72400 CGGAGGCGGC TCGGCTGGTG GCGGGTCGTG CGCGGTTGAT GCAGGCGTTG CCTTCTGGCG 72460 GTGCCATGCT GGCGGTGTCC GCGACCGAGG CCCGAGTCGG CCCGCTGCTC GATGGGGTGC 72520 GGGATCGTGT TGGTGTCGCA GCGGTTAACG CTCCGGGGTC GGTGGTGCTT TCCX3GTGACC 72580 GGGATGTGCT CGAIX^GCATT GCCGGTCGGC TGGACGGGCA AGGTATCCGG TCGAGGTGGT 72640 TGCX3GGTTTC GCACGCGTTT CATTCGCATC GGATGGATCC GATGCTGGCG GAGTTCGCCG 72700 AGCTCGCACG GAGCGTGGAC TACCGGTCTC CACGGCTGCC GATTGTCTCG ACX5CTGACCG 72760 GAAACCTCGA TGACGTGGGC GTGATGGCTA CGCCGGAGTA TTGGGTGCGC CAGGTGCGAG 72820 AGCCCGTCCG CTTCGCCGAC GGTGTCCAGG CGCTTGTGGA CCAAGGCGTC GACACGATTG 72880 TGGAACTCGG TCCGGACGGG GCGTTGTCGA GCTTGGTTCA AGAGTGTGTG GCGGAGTCCG 72940 GGCGGGCGAC GGGGATTCCG TTGGTGCGGA GAGACCGTGA TGAGGTCCGA ACGGTGCTGG 73000 ACGCTTTGGC GCAGACCCAC ACTCGTGGTG GCGCGGTGGA CTGGGGGTCA TTTTTCGCTG 73060 GTACGAGGGC AACGCAAGTC GACCTTCCCA CGTATGCCTT CCAACGACAG CGGTACTGGC 73120 TGGAGCCATC GGATTCCGGT GATGTGACCG GTGTTGGCCT GACCGGGGCG GAGCATCCGC 73180 TGTTGGGTGC CGTGGTGCCG GTCGCGGGCG GCGATGAGGT GCTGCTGACC GGCAGGCTGT 73240 CGGTGGGGAC GCATCCGTGG CTGGCGGAAC ACCGCGTGCT GGGCGAAGTC GTCGTCCCCG 73300 GCACCGCGTT GCTGGAGATG GCGTGGCGGG CCGGTAGCCA GGTCGGTTGT GAACGTGTGG 73360
96 1237058 六、申請專利範圍 AGGAGCTCAC CTTGGAGGCA CCX3CTGGTCC TGCCGGAGCG GGGCGCTGCG GCGGTGCAGT 73420 TGGCGGTGGG GGCTCCGGAT GAGGCCGGCC GGCGCAGTTT GCAGCTCTAT TCCCX3AGGCG 73480 CTGATGAAGA CGGCGACTGG COGCGGATTG CCTCCGGGCT GTTGGCCCAG GCCAATGCGG 73540 TGCCGCCGGC GGATTCGACG GCATGGCCGC CGGACGGCGC CGGGCAGGTC GATCTGGCGG 73600 AGTTCTACGA GCGCCTCGCC GAGCGCGGCT lOACCTACGG TCCGGTATTC CAAGGGCTCC 73660 GCGCCGCATG GCGGCACGGC GACGATATCT TCGCCGAATT GGCCGGGTCA CCAGACGCCT 73720 CGGGTTTCGG CATCCACCCG GCGCTGCTGG ACGCTGCACT GCACGCGATG GCGCTTGGTG 73780 CTTCGCCCGA CTCX3GAAGCG CGTCTGCCGT TTTCCTGGCG TGGCGCCCAG CTGTACCGCG 73840 CTGAAGGAGC AGCGCTTCGG GTACGGCTCT CGCCGCTGGG CTCCGGTGCA GTCTCATTGA 73900 CGTTGGTGGA TGCCACAGGG CX3ACX3AGTCG CTGCGGTGGA ATCGCTTTCG ACGCGACCGG 73960 TCTCCACCGA CCAGATCGGT GCCX3GTCGCG GCGATCAAGA GCGGCTGCTG CACGTCGAGT 74020 GGGTAAGGTC GGCTGAATCT GCX3GGGATGT CTCTGACCTC CTGCGCGGTG GTCGGTTTGG 74080 GCX3AACCX3GA GTGGCACGCT GCGCTGAAGA CCACTGGTGT CCAAGTCGAG TCCCATGCGG 74140 ACCTTGCITC GTTGGCCACC GAGGTTGCCA AGCGGGGTTC AGCTCCTGGT GCGGTCATCG 74200 TCCCGTGCCC GCGACCCCGA GCGATGCAGG AGCTGCCGAC CX^TCGCGCGA AGGGCGACGC 74260 AACAGGCGAT GGCGATGCTG CAGCAATGGC TTGCCGATGA CCGGTTCGTC AGTACGC!GCC 74320 TGATCCTGCT GACGCATCGG GCGGTCTCCG CAGTTGCTGG AGAAGACGTG CTCGACCTGG 74380 TACACGCGCC GCTGTGGGGC TTGGTCCGCA GCGCGCAAGC GGAGCACCCG GACCGATTCG 74440 CCTTGATCGA TATGGACGAC GAGCGAGCAT CGCAGACGGC ACTCGCCGAA GCGCTGACTG 74500 CGGGAGAAGC GCAGCTCGCG GTGCGGTCGG GAG1TGTGCT GGCGCCCCX3C CTCGGCCAGG 74560 TGAAGGTGAG TGGAGGTGAA GCGTTCAGGT GGGATGAAGG CACCGTGCTG GTCACCGGCG 74620 GAACCGGCGG GCTCGGGGCC CTGCTCGCAC GCCATCTGGT CAGCGCCCAC GGTGTGCGGC 74680 ACCTGTTGCT CGCAAGTCX5C CGTGGTCTGG CGGCGCCCGG AGCGGATGAG CTGGTGGCCG 74740 AGCTGGAGCA GGCCGGCGCC GACGTCGCGG TCX5TCGCGTG CGACTCGGCA GATCGGGACT 74800 CGCTTGCGCG GCTGGTGGCG TCGGTGCCTG CGGAAAACCC GTTGCGGGTG GTGGTGCACG 74860 CCGCCGGTGT GCTGGATGAC GGTGTGCTGA TGTCGATGTC GCCGGAGCGC TTGGACGCGG 74920 TGTTGCGGCC CAAAGTGGAT GCCGCGTGGT ACCTGCACXSA GCTGACTCGG GAACTCGGTC 74980 TGTCGGCGTT CGTGTTGTTC TCCTCGGTCG CGGGCCTGTT CX3GCGGTGCG GGGCAGAGCA 75040 ATTACGCTGC CGGCAACGCT TTCCTGGATG CCTTGGCGCA TTGCCGGCAG GCCCAGGGGC 75100 TGCCCGCGCT GTCGCTGGCC TCCGGGCTGT GGGCGAGTAT CGATGGAATG GCGGGCGACC 75160 TCGCTGCGGC AGATGTGGAG CX3GCTGTCX5C GGGCAGGCAT TGGCCCGCTT TCGGCACCGG 75220 GAGGGCTGGC CITGTTCGAC GCTGCCGTTG GCTCGGACGA ACCGTTGCTG GCACCGGTGC 75280 GACTGGATGT CGAAGCACTG CGTGTGCAGG CCCmTCCGT GCAGACCCX3G ATTCCGGAAA 75340 TCCTGCATGG CATGGCAATG GGGCCAAGCC GCOSCACTCC GTTCACTTCC AGGGTTGAGC 75400 CGITGCACGA ACGGCTGGCC GGA1TGTCGG AGGGCGAACG TCGGCAGCAA GTGCTCCAGC 75460 GCGTCCGCGC CGATATCGCG GTGGTACTGG GGCACGGCAG GTCGAGCGAT GTGGACATCG 75520 AGAAGCCTTT GGCCGAGCTG GGTTTCGACT CGCTGACX3GC CATCX5AACTC CGCAACCGTC 75580 TCX3CTACCGC CACCGGACTG CX3GCTTCCCO CGACGCTGGC CTTCGACCAC GGCACTGCGG 75640 CGGCACTCGC CCAGCAGGTG TGCGCGCAGC TAGGCACCGC GACCX5CGCCG GCACCGAGGC 75700 GAACCGACGA CAACGACGCC ACGGAGCCCG TGAGGTCGCT CTTCCAACAG GCGTATGCGG 75760 CTGGCCGGAT ACTTGACGGG ATGGATTTGG TGAAGGTCGC TGCCCAGTTG CGACCGGTGT 75820
1237058 六、申請專利範圍 TCGGTTCGCC TGGCGAGCTG GAATCCCTGC CGAAACCCGT CC^GCTTTCC COTGGTCCCG 75880 AAGAGCTTGC CTTGGTGTGC ATGCCGGCX3C TGATCGGGAT GCCGCCCX3CA CAGCAGTACG 75940 CGCGGATCGC CGCCGGGTTC CGCGATGTGC GGGACGTTTC GGTGATCCCG ATGCCTGGAT 76000 TCATTGCX3GG AGAACCGCTG CCGTCCGCCA TCGAGGTGGC GGTTCGGACG CAGGCGGAGG 76060 CGGTGCTGCA GGAATTCXSCC GGGGGCTCOT TCGTACTGGT CGGGCATTCC TCCGGGGGCT 76120 GGCTGGCGCA CGAGGTAGCC GGTGAGCTGG AGCGTCGCX3G GGTCOTCCCG GCCGGGGTCG 76180 TACTCCTGGA CACCTACATC CCCX3GTGAGA TCACGCCX^G GTTCTCCGTG GCGATGGCCC 76240 ACCGGACGTA TGAGAAGCTC GCGACITTCA CGGACATGCA GGATGTCGGT ATCACCGCGA 76300 TGGGCGGGTA CTTCCGGATG TTCACCGAGT GGACTCCX5AC GCCGATCX3GT GCTCC!GACGC 76360 TGTTCOTGCG GACCGAAGAT TGCOTCGCAG ACCCTGAAGG GCGGCCG1X3G ACAGATGACT 76420 CCTGGCGGCC AGGGTGGACT CTCGCGGATG CCACGGTCCA GGTGCCGGGC GACCACTTCT 76480 CGATGATGGA CX3AGCACGCC GGGTCCACCG CACAGGCAGT CGCGAGTTGG CITGACAAAC 76540 TCAACCAGCG CACCGCTCGG CAACGCTGAC GGGCGTCCTT TTAGGACCTT CTGGGCGGCA 76600 CCGGCCACCC CGGCGGTGCC GCCITCCGTG GTCCAGGCTC GCCGATCTTG ACX3GCGCACX5 76660 ATGCGCGGCA CGCX5CGCTGA TCX3TGATTCC GCTGCCGCTC GTGGCCATCG GCCTGGCGAA 76720 TCATGTCCTT TCGGGCAACG TCAAACGAAT TCGTCCX5AGC CCGCATTCCG AGGTGAGGGG 76780 CACCCTTGGG TGGCTGAGCC GCTCAAGGGT GCCCCTCACC TQ^AAATTCG TCCGATITGG 76840 GCGGTGGACG CAACCCCGGT GGGCX3TGGTG CGTCITTCTT GTTGACAGAG CGGTGAGAAG 76900 CCGCTGACAC ACCTGAGAGG AAAAGGGGAG CATGATGCTC AAGCGCCACC GTTTGACGAC 76960 CGCCATCACC GGCCTTCTGG GGGGAGTACT GCTGGTCAGC GGCTGCGGAA CCX3CCX5CCGC 77020 ACTTGAGTCC TCGCCGGCGC CCGGGCATGA CGCGCGCAAT GTTGGTATGG CCTCGGGCGG 77080 GGGCGGCGGG GACATCGGCA CGTCXSAACTG CTCGGAGGCC GATTTCCTCG CCACCX5CGAC 77140 ACCGGTGAAA GGCGACCCCG GCAGTTTCAT CGTGGCGTAC GGGAACCGGT CGGACAAGAC 77200 CTGCACGATC AACGGCGGCG TGCCGAACCT CAAGGGCGTG GACATGAGCA ACTCGCCX3AT 77260 CGAGGACCTG CCGGTCGAGG ACGTGCGGCT TCCCGACGCG CCCAAGGAAT TCACCCTCCA 77320 GCCCX3GTCAG AGCGCGTACG CCGGCATTGG CATGGTCCTG GCCXSACAGCG GCGACCCGAA 77380 CGCCCATGTC CTCACCGGGT TCCAGTCCTC GCTGCCGGAC ATGTCCGAGG CCCAGCCGGT 77440 CAACGTTCTC GGCGACGGCA ACGTGAAGTT CGCCGCX3AAG TACCTGCGAG TCAGCTCGCT 77500 GGTGTCTACC GCAGACGAGC TGCGCTAAAA CCCATGTGAG TCCCGCAGAT TCGACCTCGC 77560 CGTGCGGCGC CTCCGGCX3AA GCGTCCGTAC GTTTGTCGTT GTGACCAGCG TTGTTCACGT 77620 CCGGGCGCAG CGCTGGTACA TACTCAGGCG TCTCGGGCGC CTCCAACGGG GCCTGGCATC 77680 CX3GGGCCGTC GAGTGCGGCG GCGCTGACGC GTTCTCTGTC GGGCGTTGTC ACGCCGCCGG 77740 CCTCGAACCG GTCCCGCCCC GTCGGAGCCG GTGGTCCAGC GCGGTGTGGC GGCGGCCGGA 77800 GCCGACGGTG CGCACCGCCT GCCCGAGGGC CTITTTCGAA CCGACGAGGA CCACGACCTT 77860 CTTGGCCCGG GTGACCGCCG TGTAGAGCAG GTimXTGC AGCATCATCC AGGCGCTTGT 77920 GGTCAAGGGG ATCACCACX3C ACGGGTATTC GCTTCCCTGC GAACGATGGA TGGTCACCGC 77980 GTAGGCGTGG ACCAGTTCX5T CGAGTTCTGT GAAGTCGTAG TCGATGTCCT CGTCCTCX3TC 78040 GGTTCGCACG GTCATGGTCT GTGCTTCGTT GTCGAGGGCG GACACX3ACGC CCTGCOTGCC 78100 GTTGAACACG CCGTTGGCGC CCTTGTCGTA GTTGTTGCGG ATCTGCGTGA CCTTGTCGCC 78160 GACGCGGAAG ATCCGTCCGC CGAACCGCCG CTCTGGCAGG CCCTCCCTGG CCGGGGTGAT 78220 CGCTTCCTGC AACAGCTGGT TCAGCGCGCC TGCACCTGCG GGGCCTCGAT GCATCGGGGC 78280
98 1237058 六、申請專利範圍 GAGGACCTGC ACOTCGGTGC GCGGGTTGAA CCGGAACTTC CGCX3GAATCC GGCGGGCGAC 78340 GACX3TCGACG GTGAGCTCX3G CGGTCGGTTC GCTTTCCTCT ACX5TGGAACA GGAAGAAGTC 78400 GGTCAGCCCG TGTGTCAGCG GATAGTCCCC GGCGTTGATT CGGTGCGCGT TGGTCACCAC 78460 CCCX3GACTCG GCGGCCTGCC GGAACACCTC GTTGAGCCGC ACGTGTGGAA TCGGGGTGCC 78520 AGGGGCGAGC AGATCGCGCA GTACCTCACC GGCTCCGACC GACGGGAGCT GGTCGACGTC 78580 GCCGACCAGC AGCAGGTGCG CGCCGGGCGC GATCGCCTTG GCCAGTTTGT TGGCTAACAG 78640 CAGGTCGAGC ATGGACGCCT CGTCGACCAC GACGAGGTCG GCGTCCAGCG GGTTGTCCCG 78700 GTCGTAGGCG GCGTCCCCXX： CCGGCTGGAG TTGGAGCAGG CGGTGCACGG TCGCCGCGTC 78760 GTGTCCGGTG AGCTCGGTCA GCCGCTTCGC CGCTCGTCCC GTCGGCGCGG CGAGGATCAC 78820 CTIX^CTTT TTCGCCTGAG CTAATGCGAT GATCGACCGC ACGGTGAAGC TCTTGCCGCA 78880 GCCTGGACCT CCGGTGAGCA CGGCX5ACCTT CTCGGTCAGG GCCAGCTTGA CGGCGCGCTC 78940 CTGCGCCTCG GCGAGTTCGG CACCGGTAGC GCGGCGCAAC CAGTCGAGGG CCTTGTGCCA 79000 ATCGACGTCG GCGAAGACGG GCATCCGGTC CGCGCTGGTG TTCAGCAGCC GGGACAGCTG 79060 GTTGGCCAGG GCGACTTCGG CGCGGTGGAA GGGCACGAGG TAGATCGCGA CCGTCGGCAC 79120 CTCGTCGTCA TCGGTGGGGA TCTCCTCGCG GACCACACCT TCCTCX3GTGA CGAGTTCX3GC 79180 GAGGCATTCG ATCACCAGCC CGGTGTCGAC GGCGAGGATC TTCACCXX：CT CGGCGATCAG 79240 CTCGTTCTCC GGCAGGTAGC AGTTGCCGTC GCCX3GTGGAC TCCGACAGCG TGAACTGAAG 79300 GCCCGCCTTT ACCCGCTGCG GGGAGTCGTG CGGGATTCCC ACCGCTTTGG CX3ATGGTGTC 79360 GGCGGTCTTG AAACCX3ATTC CCCACACGTC GCCTGCCAGC CGGTATGGCT CTTCCTTGAC 79420 GGTCCGGATC GCGTCGTCGT GGTACTGCIT GTAGATCTTC ACCGCCAGCG AGGTCGAGAC 79480 GCCX^CGCCT TGCAGGAAGA TCATCACCTC CTTGATCGCC TTCTGCTCCT CCCACGCGTC 79540 GGCGATCAGC TTCGTCCX^T TCGGGCCGAG CTTGGGGACC TCGATCAGCC GCGCGGGTTC 79600 CTGCTCGATG ACGTCGAGCG CGGCGACGCC GAAGTGGTCG ACGATCTTCT CGGCGAGTTT 79660 GGGGCCGATG CCCTTGATCA GGCCAGACCC CAGGTAGCGG CX3GATACCTT GCACGGTCGC 79720 AGGCAGCACG GTCGTGTAGT CGTCGACX3TG GAACTGCCJGC CCGTACTGGG GGTGCX3ACCC 79780 CCACCGGCCG CGCATGCGCA ACGCCTCGCC GGGCTGCGCG CCCAGCAGCG CGCCGACGAC 79840 CGTCACCAGG TCACCX3CCCC GGCCGGTGTC GATCCGCGCG ACGGTGTAGC CGCTCTCCTC 79900 GTTGGCGAAC GTGATCCGCT CCAGCGTGCC CTCCAGCACC GCAGTCCACG TGGCCGACTC 79960 CCGTCCITIT TCCACCGACA ACACGTATCA CX3AACX3GCTG TCAAGCAAAC CGGCGGTCAC 80020 CACATGCAGC GGCATCTCCC GAACX3CCTCG GGCTCCGGCG TCAGCGGGTG GGCGTTCGCG 80080 ATGCCTTGGT GCGGCCGGTG GGAGTTGTAG ATTTTTTCGT CCTCGCGCAG GGCCTGGAGT 80140 AGGTGCCGCT GGCTCCAGAT C 80161 序列辨識號碼:28 AAGGCCACCG GCAAGGTCGT GCAGGGCATC TCGCAGGACG TCGCGAAGAA GATCTCCAAG 60 AAGATCCX3CG ACGAGGGCCC GAAGGGCGIT CAGGCCCAGA TCCA.GGGCGA GC^GCTGCGG 120 GTGTCCGGCA AGAAGAAGGA CX5ACCTGCAG GCCGTGATCC AGTTGCTGAA GTCX3AGCGAC 180 TTCGACGTCG CGCTCCAGTT CGAGAATTTC CGGTAATCCA CCGCTGGAGG TATCCGGGTG 240 AAGGGGATCG TGCTGGCGGG TGGCAACX3GG ACCCX3GCTGC ATCCGCTGAC GCAGGCCGTG 300 TCCAAACAGC TACTTCCGGT GTACGACAAG CCG ATG ATC TAC TAC CCG CTG TCG 354 Met lie Tyr Tyr Pro Leu Ser 1 5
99 1237058 t、申請專利範圍 GTG CTG ATG CTG GCC GGC ATC CGG GAC GTG CTG CTG ATC TCG ACC CCG 402 Val Leu Met Leu Ala Gly He Arg Asp Val Leu Leu He Ser Thr Pro 10 15 20 GCC GAC ATG CCG TTG TTC CAG CGG CTG CTC GGG AAC GGG TCG CAG TTC 450 Ala Asp Met Pro Leu Phe Gin Arg Leu Leu Gly Asn Gly Ser Gin Phe 25 30 35 GGC ATT CGG ATC GAG TAC GCC GAG CAG TCC CAG CCC AAC GGG CTA GCC 498 Gly He Arg He Glu Tyr Ala Glu Gin Ser Gin Pro Asn Gly Leu Ala 40 45 50 55 GAG GCG TTC GTG ATC GGT GCC GAC TTC GTC GGC GAC GAC TCG GTG GCG 546 Glu Ala Phe Val lie Gly Ala Asp Phe Val Gly Asp Asp Ser Val Ala 60 65 70 TTG GTG CTC GGC GAC AAC ATC TTT TAC GGG CAG GGC TTT TCC GGG ATC 594 Leu Val Leu Gly Asp Asn lie Phe Tyr Gly Gin Gly Phe Ser Gly lie 75 80 85 CTC CAG CAG TGC GTC CGG GAG CTC GAC GGC TGC ACG CTG TTC GGC TAC 642 Leu Gin Gin Cys Val Arg Glu Leu Asp Gly Cys Thr Leu Phe Gly Tyr 90 95 100 CCG GTC CGC GAC CCG CAG CGC TAC GGC GTC GGT GAG GTG GAC GAC GAC 690 Pro Val Arg Asp Pro Gin Arg Tyr Gly Val Gly Glu Val Asp Asp Asp 105 110 115 GGT CGG CTG TTG TCC ATC GTG GAG AAG CCX； GAG CGG CCG AAG TCC AAC 738 Gly Arg Leu Leu Ser lie Val Glu Lys Pro Glu Arg Pro Lys Ser Asn 120 125 130 135 ATG GCC ATC ACC GGC CTG TAC TTC TAC GAC AAC GAC GTG GTG CGC ATC 786 Met Ala lie Thr Gly Leu Tyr Phe Tyr Asp Asn Asp Val Val Arg lie 140 145 150 GCC AAG GGG CTC ACG CCG TCG GCC CGC GGC GAG CTG GAG ATC ACC GAC 834 Ala Lys Gly Leu Thr Pro Ser Ala Arg Gly Glu Leu Glu lie Thr Asp 155 160 165 GTC AAC CTG GCC TAC CTG CAG GAG GGC CGG GCG CAC CTG ACC AAG CTC 882 Val Asn Leu Ala Tyr Leu Gin Glu Gly Arg Ala His Leu Thr Lys Leu 170 175 180 GGC CGC GGG TTC GCC TGG CTG GAC ACC GGG ACC CAC GAC TCG CTA GTG 930 Gly Arg Gly Phe Ala Trp Leu Asp Thr Gly Thr His Asp Ser Leu Val 185 190 195 GAG GCC TCG CAG TTC GTG CAG GTG CTG GAG CAC CGG CAG GGC GTG CGG 978 Glu Ala Ser Gin Phe Val Gin Val Leu Glu His Arg Gin Gly Val Arg 200 205 210 215 ATC GCC TGC CTG GAG GAG ATC NCC CTG CGC ATG GGC TAC ATC TCG GCC 1026
1237058 六、申請專利範圍 lie Ala Cys Leu Glu Glu lie ??? Leu Arg Met Gly Tyr lie Ser Ala 220 225 230 GAC GAC TGT TTC GCG CTG GGC GTG AAG CTG GCC AAG TCG GGC TAC AGC 1074 Asp Asp Cys Phe Ala Leu Gly Val Lys Leu Ala Lys Ser Gly Tyr Ser 235 240 245 GAG TAC GTC ATG GAC GTC GCC CGC AAC TCC GGC GCG CGG GGC TGA 1119 Glu Tyr Val Met Asp Val Ala Arg Asn Ser Gly Ala Arg Gly 250 255 260 CCCGAGCTCG TCCGATTTCC ATTGAAATCX3 CGGACCGTCG GCGTGTCGTA GTCCX3GTGCG 1179 CCGATATTCC GGGCGGCGTC ACCAGGCCGG GGGTAGTTGG TGGCCGGCCA TGCCCTCCAG 1239 GCGGCGAAAT GCGGTCX3GCC ATCGGCGGGT TGC 1272 序列辨識號碼:25 GGATCCTGCT TCGTAGCTCG GTGTGTCATC CCAGACTGCG CACGCGGACC TGCAGCGGGC 60 CGCGAAATCC CGGCGAGGAA GGGCX3CG ATG CX3G ATT CTG GTC ACC GGC GGA 111 Met Arg He Leu Val Thr Gly Gly 1 5 GCC GGT 1TC ATC GGC TCG CAC TAC GTT CGG CAG TTG CTC GGT GGT GCG 159 Ala Gly Phe lie Gly Ser His Tyr Val Arg Gin Leu Leu Gly Gly Ala 10 15 20 TAC CCC GCA TTC GCC GAC GCC GAC GTG GTC GTG CTC GAC AAG CTC ACC 207 Tyr Pro Ala Phe Ala Asp Ala Asp Val Val Val Leu Asp Lys Leu TTir 25 30 35 40 TAC GCC GGC AAC GAG GCG AAC CTG GCG CCG GTC GCG GAC AAC CCC CGG 255 Tyr Ala Gly Asn Glu Ala Asn Leu Ala Pro Val Ala Asp Asn Pro Arg 45 50 55 CTG AAG TTC GTC TGC GGC GAC ATC TGC GAC CGC GAA CTG GTT GGC GGC 303 Leu Lys Phe Val Cys Gly Asp lie Cys Asp Arg Glu Leu Val Gly Gly 60 65 70 CTG ATG TCC GGC GTG GAC GTG GTG GTG CAC TTC GCC GCC GAA ACC CAC 351 Leu Met Ser Gly Val Asp Val Val Val His Phe Ala Ala Glu Thr His 75 80 85 GTC GAC CGC TCG ATC ACC GGC TCG GAC GCC TTC GTG ATC ACC AAC GTG 399 Val Asp Arg Ser lie Thr Gly Ser Asp Ala Phe Val lie Thr Asn Val 90 95 100 GTC GGC ACC AAC GTC CTG CTG CAG GCC GCG CTC GAC GCC GAG ATC GGC 447 Val Gly Thr Asn Val Leu Leu Gin Ala Ala Leu Asp Ala Glu lie Gly 105 110 115 120 AAG TTC GTG CAC GTT TCC ACC GAC GAG GTC TAC GGC TCC ATC GAG GAC 495 Lys Phe Val His Val Ser Thr Asp Glu Val Tyx Gly Ser lie Glu Asp 125 130 135 GGC TCG TGG CCC GAA GAC CAC GCG CTG GAG CCG ΑΆΤ TCC CCG TAC TCG 543
101 1237058 六、申請專利範圍 Gly Ser Trp Pro Glu Asp His Ala Leu Glu Pro Asn Ser Pro Tyr Ser 140 145 150 GCG GCG AAA GCG GGC TCG GAC CTG CTG GCC CGC GCC TAC CAC CGC ACC 591 Ala Ala Lys Ala Gly Ser Asp Leu Leu Ala Arg Ala Tyr His Arg Thr 155 160 165 CAC GGA CTG CCG GTG TGC ATC ACC CGC TGC TCC AAC ΆΑΟ TAC GGG CCC 639 His Gly Leu Pro Val Cys lie Thr Arg Cys Ser Asn Asn Tyr Gly Pro 170 175 180 TAC CAG TTC CCG GAG AAG GTG CTG CCG CTG TTC ATC ACG AAC CTG ATG 687 Tyr Gin Phe Pro Glu Lys Val Leu Pro Leu Phe lie Thr Asn Leu Met 185 190 195 200 GAC GGC AGC CAG GTG CCG CTC TAC GGC GAC GGG CTC AAC GTG CGG GAC 735 Asp Gly Ser Gin Val Pro Leu Tyr Gly Asp Gly Leu Asn Val Arg Asp 205 210 215 TGG CTG CAC GTC AGC GAC CAC TGC CGG GGC ATC CAG CTG GTG GCC GAC 783 Trp Leu His Val Ser Asp His Cys Arg Gly lie Gin Leu Val Ala Asp 220 225 230 TCC GGG CGC GCG GGC GAG ATC TAC AAC ATC GGC GGC GGC ACC GAG CTG 831 Ser Gly Arg Ala Gly Glu lie Tyr Asn lie Gly Gly Gly Thr Glu Leu 235 240 245 ACC AAC AAC GAG CTG ACC GAG CGG CTG CTG GCA GAG CTG GGC CTC GAC 879 Thr Asn Asn Glu Leu Thr Glu Arg Leu Leu Ala Glu Leu Gly Leu Asp 250 255 260 TGG TCG GTG GTG CGG CCG GTC ACC GAC CGC AAG GGC CAC GAC CGC CGC 927 Trp Ser Val Val Arg Pro Val Thr Asp Arg Lys Gly His Asp Arg Arg 265 270 275 280 TAC TCG GTG GAC CAC AGC AAG ATC GTC GAG GAA CTG GGG TAC GCG CCG 975 Tyr Ser Val Asp His Ser Lys lie Val Glu Glu Leu Gly Tyr Ala Pro 285 290 295 CAG GTC GAC TTC GAG ACC GGG CTG CGC GAG ACA ATC CGC TGG TAC CAG 1023 Gin Val Asp Phe Glu ΊΊίγ Gly Leu Arg Glu Thr lie Arg Trp Tyr Gin 300 305 310 GAC AAC CGG GAC TGG TGG GAG CCG CTG AAG GCC CGA TCG GCG GTG GCT 1071 Asp Asn Arg Asp Trp Trp Glu Pro Leu Lys Ala Arg Ser Ala Val Ala 315 320 325 CGA TGA GTCGCCTCGC CGTGCTGGTT GCCCX3GCGGC CGCGGCCAGC TGGGCTCGGA 1127 Arg ★ 329 GCTGGCCCGG ATCCTCGCCG CGCGGACGGG GGCGCTG GTG CAC CGG CCG GGT TCC 1182 Val His Arg Pro Gly Ser 1 5
102 1237058 t、申請專利範圍 GGG GAA CTG GAC GTC ACC GAC GCC GAG GAG GTC GCC GAC GCG TTG GGT Gly Glu Leu Asp Val Thr Asp Ala Glu Glu Val Ala Asp Ala Leu Gly 10 15 20 TCC TTC GCG GAG ACG GCG AAG GAC GCG GAG CTG CGA CCO GTG GTG ATC Ser Phe Ala Glu Ίΐατ Ala Lys Asp Ala Glu Leu Arg Pro Val Val lie 25 30 35 AAC GCC GCG GCG TAC ACG GCG GTG GAC GCG GCC GAG TCC GAC CCG GAC Asn Ala Ala Ala Tyr Thr Ala Val Asp Ala Ala Glu Ser Asp Pro Asp 40 45 50 CGC GCG GCC CGG ATC AAC GCC GAA GGC GCG GCC TCG CTG GCG AAA GCG Arg Ala Ala Arg lie Asn Ala Glu Gly Ala Ala Ser Leu Ala Lys Ala 55 60 65 70 TGC CGG AGC AGC GGT CTG CCC CTG GTG CAC GTG TCG ACG GAT TAC GTG Cys Arg Ser Ser Gly Leu Pro Leu Val His Val Ser Thr Asp Tyr Val 75 80 85 TTC CCC CGT GAT GGG GCC CGG CCG TAC GAG CCG ACG GAC CCG ACC GGG Phe Pro Arg Asp Gly Ala Arg Pro Tyr Glu Pro Thr Asp Pro Thr Gly 90 95 100 CCG CGA TCG GTC TAC GGG CGC ACC AAG CTC GAA GGC GAA CX3G GCC GTG Pro Arg Ser Val Tyr Gly Arg Thr Lys Leu Glu Gly Glu Arg Ala Val 105 110 115 CTG GAG TCC GGC GCG CGG GCC TGG GTG GTG CGC ACG GCA TGG GTG TAC Leu Glu Ser Gly Ala Arg Ala Trp Val Val Arg Thr Ala Trp Val Tyr 120 125 130 GGC GCG AGC GGC AAG AAC 1TC CTG AAA ACG ATG ATC CGC CTC TCG GGG Gly Ala Ser Gly Lys Asn Phe Leu Lys Thr Met lie Arg Leu Ser Gly 135 140 145 150 GAG CGC GAC ACG CTG TCC GTT GTG GAC AAT CAG ATC GGC TCO CCG ACT Glu Arg Asp Thr Leu Ser Val Val Asp Asn Gin lie Gly Ser Pro Thr 155 160 165 TGG GOG GCG GAC CTG GOG AGC GGC CTG CTG GAG CTG GCC GAA OGG GTC Trp Ala Ala Asp Leu Ala Ser Gly Leu Leu Glu Leu Ala Glu Arg Val 170 175 180 GCC GAA CGC CGT GGA CCG GAG CAG AAG GTG CTG CAC TGC ACC AAT TCC Ala Glu Arg Arg Gly Pro Glu Gin Lys Val Leu His Cys Thr Asn Ser 185 190 195 GGC CAG GTG ACC TGG TAC GAG TTC GCG CGG GCG ATC TTC GCG GAA TTC Gly Gin Val Thr Trp Tyr Glu Phe Ala Arg Ala lie Phe Ala Glu Phe 200 205 210 GGC CTG GAC GAG AAC CGC GTC CAC CCG TGC ACG ACG GCG GAC TTC CCC 1230 1278 1326 1374 1422 1470 1518 1566 1614 1662 1710 1758 1806 1854
103 1237058 六、申請專利範圍 Gly Leu Asp Glu Asn Arg Val His Pro Cys Thr Thr Ala Asp Phe Pro 215 220 225 230 CTC CCG GCG CAC CGC CCG GCC TAC TCG GTC CTG TCC GAC GTG GCG TGG Leu Pro Ala His Arg Pro Ala Tyr Ser Val Leu Ser Asp Val Ala Trp 235 240 245 CGA GAG GCG GGC CTG ACC CCG ATG CGC ACC TGG C!GG GAA GCC CTG GCG Arg Glu Ala Gly Leu Thr Pro Met Arg Thr Trp Arg Glu Ala Leu Ala 250 255 260 GCG GCC TTC GAG AAA GAC GGC GAA ACC CTC CGA ACC CGC TGA Ala Ala Phe Glu Lys Asp Gly Glu Thr Leu Arg Thr Arg * 265 270 275 CCAGTCACCC GGAGGGCX5CG AGTAGCCCCG GCAGGGCCGT TTCGACGCGA TATCGGCTGG CGCGGTGCGC ACAATGGGTG TCGCCGGGGC GAGGAAGGAA GGCCAGGTGC CCCX3GGGGCA TGACTGGGAG CCIOGCCTGA TGCCTGTCCG GGGCGTTCAG CCTGCGGCX5A GGCGGTATGC GTTCAGGGTT GCTTCGGCGC AGGTTCGCCA GGTGAAGGCT TTAGCITGGG CACGGCCCTT TTCCGCGTCT GGGGGACTGG TCAGGGCITG GTGCAGGGCT TCGTTGAGGG CCGTCGGGTC GCCGTGGGGG AAGCGGAT 序列辨識號碼:32 GGGATCAACA ACAACTTCAC CAGCAGGTTC AACAATTTGT CAATCCCACT TGGCAGTACG CGCGTCCTTT TTGGATCGGG ATTGCX3GCAG TACGTGCACC CGGTTTCAGT GCCCCATTTC GCAGTACGTA CGTCCGTTTT GAATATGGCG ATCAATGGCT CGCAIX5ACCC ATATCAACTC CGCCCCACCG AACCGCATTC CAACCAACGT CATAGGCTTT CGGCC GTG CAG GTA Val Gin Val 1 CGT CGA CTT GAC ATC ACG GGT GCA TAC GAG TTC ACC CCG AAG GCC TTC Arg Arg Leu Asp lie Thr Gly Ala Tyr Glu Phe Thr Pro Lys Ala Phe 5 10 15 CCC GAC CAC CGG GGC CTG TTC GTG GCC CCG TTC CAG GAG GCG GCG TTC Pro Asp His Arg Gly Leu Phe Val Ala Pro Phe Gin Glu Ala Ala Phe 20 25 30 35 ATC GAC GCC ACG GGG CAC CCG CTG CGA GTC GCG CAG ACC AAC CAC AGC lie Asp Ala Thr Gly His Pro Leu Arg Val Ala Gin Thr Asn His Ser 40 45 50 GTC TCG GCG CGC AAC GTC ATC CGC GGC GTG CAC TTC TCG GAC GTG CCG Val Ser Ala Arg Asn Val lie Arg Gly Val His Phe Ser Asp Val Pro 55 60 65 CCG GGC CAA GCG AAG TAC GTG TAC TGC CCG CAG GGC GCG CTG CTC GAC Pro Gly Gin Ala Lys Tyr Val Tyr Cys Pro Gin Gly Ala Leu Leu Asp 7〇 75 80 1902 1950 1992 2052 2112 2172 2232 2292 2310 60 120 180 234 282 330 378 426 474
104 1237058 t、申請專利範圍 GTG GTC ATC GAC ATC CGG GTC GGT TCC CCG ACC TTC GGC CGC TGG GAG 522 Val Val lie Asp lie Arg Val Gly Ser Pro Thr Phe Gly Arg Trp Glu 85 90 95 GCG GTC CGG CTC GAC GAC ACC GAG TAC CGG GCC GTC TAC CTA GCC GAA 570 Ala Val Arg Leu Asp Asp Thr Glu Tyr Arg Ala Val Tyr Leu Ala Glu 100 105 110 115 GGA CTC GGG CAC GCG TTC GCC GCX3 CTG ACC GAC GAC ACC GTG ATG ACC 618 Gly Leu Gly His Ala Phe Ala Ala Leu Thr Asp Asp Thr Val Met Thr 120 125 130 TAC CTC TGC TCG ACG CCC TAC ACC CCG GGC GCC GAG CAC GGC ATC GAC 666 Tyr Leu Cys Ser Thr Pro Tyr Thr Pro Gly Ala Glu His Gly lie Asp 135 140 145 CCG TTC GAC CCG GAA CTC GCG TTG CCG TGG TCC GAC CTC GAC GGT GAA 714 Pro Phe Asp Pro Glu Leu Ala Leu Pro Trp Ser Asp Leu Asp Gly Glu 150 155 160 CCG GTC CTG TCC GAA AAG GAC CGG ACC GCC CCG AGC CTC GCG GAA GCC 762 Pro Val Leu Ser Glu Lys Asp Arg Thr Ala Pro Ser Leu Ala Glu Ala 165 170 175 GCC GAC AAC GGC CTG CTT CCG GAC TAC GAA ACA TGC CTC GCC CAC TAC 810 Ala Asp Asn Gly Leu Leu Pro Asp Tyr Glu Thr Cys Leu Ala His Tyr 180 185 190 195 GAA GGC CTG CGC AGC CCC GGC TGA ACGGTCACCG CAAGCGGCCC GGCTTCGGCC 864 Glu Gly Leu Arg Ser Pro Gly ★ 200 AGAGGCGCCA CCGGATAATG CCGAGCACCT CGGCCGGGCC GAGCTCCCGC GAGTCCGTCG 924 AGCCGAAGTT GTTGTCGCCC TCGACGTACC AGCCATCGCC CTCGCGGCGC AGCGCGCGCT 984 TCACCGACAA CTGCCCCGGG CGCTGGGCCC AACGCACCAG CACGACGTTT CCCCGGCCGG 1044 GCGGAACCCC GAAGCCGCAG CAGCACCACT TCGCGATCCC GCAGGGTGGG AACCATAAAC 1104 GGCCCGCGCA CCACCAACCG CCGCCAGGGC CAGCGCCCGA GGGATTTCAC ATCCACCTCC 1164 A 1165 〇 3. —種分離的DNA分子，其由一個編碼史賓諾辛PKS區域 之DNA序列所組成，該區域係擇自於KSi、ATi、 ACPi、KS1、ATI、KR1和ACPI，此等分別對應於如 申請專利範圍第1項中所示之序列辨識編號：2的胺基酸 序列 6-423、528-853、895-977、998-141 3、1 525-1 858、2 1 58-2337 和 2432-25 1 3 °
105 1237058 六、申請專利範圍 4.如申請專利範圍第3項之分離DNA分子，其中該DNA序 列係擇自於由下列所構成之群組：如申請專利範圍第2項 中所示的序列辨識編號：1之鹼基21 126-22379、 22692-23669 、 23793-24041 、 24102-25349 、 25683-26684 、 27582-28121和28404-28649 。 5· —種分離的DNA分子，其由一個編碼史賓諾辛pks區域 之DNA序列所組成，其中該區域係擇自於KS2、AT2、 DH2、ER2、KR2和ACP2，此等分別對應於如申請專利 範圍第1項中所示的序列辨識編號：3之胺基酸序列j _ 424、536-866、892-1077、1338-1 683、1687-1866和 1955-2034 。 6.如申請專利範圍第5項之分離分子，其中該DNA序 列係擇自於由下列所構成之群組：如申請專利範圍第2項 中所示的序列辨識編號·· 1之鹼基29024-30295、 30629-31621 、 31697-32254 、 33035-34072 、 34082-34621 、 34886-35125 。 7· —種分離的DNA分子，其由一個編碼史賓諾辛PKS區域 之DNA序列所組成，該區域係擇自KS3、AT3、KR3、 ACP3、KS4、AT4、KR4和ACP4，此等分別對應於如 申請專利範圍第1項中所示的序列辨識編號：4之胺基酸 序列 1-423、53 1-280、1 159-1337、1425-1506、 1 529-1952、2066-2396、2700-2880和2972-3053。 8·如申請專利範圍第7項之分離DNA分子，其中該DNA序 列係擇自於由下列所構成之群組··如申請專利範圍第2項 中所示的序列辨識編號：！之鹼基355 1 8·36786、 106 1237058 六、申請專利範圍 37108-38097 > 38992-39528 > 39790-40035 ^ 40102-41373 、 41713-42705 、 43615·44157 和 44431- 44676 〇 9· 一種分離的DNA分子，其由一個編碼史賓諾辛pks區域 之DNA序列所組成，該區域係擇自於KS5、ΑΤ5、 DH5、KR5、ACP5、KS6、ΑΤ6、KR6、ACP6、 KS7、ΑΤ7、KR7和ACP7，此等分別對應於如申請專利 範圍第1項中所示之序列辨識編號：5的胺基酸序列1_ 424、539-866、893-1078、1384·1565、1645-1726、 1748-2172 、 2283-2613 、 2916-3095 、 3188-3269 、 3291-3713、3825-4153、4344-4638和4725-4806。 10·如申請專利範圍第9項之分離DNA分子，其中該DNA序 列係擇自於由下列所構成之群組：如申請專利範圍第2項 中所示的序列辨識編號：1之鹼基45077-46348、 46691-47674 、 47753-48310 、 49226-49771 、 50009-50254 ^ 50318-51592 - 51923-52915 - 53822- 54361 、 54638-54883 、 54947-56215 、 56549- 57535 、 58106-58990和59249-59494 。 11· 一種分離的DNΑ分子，其由一個編碼史賓諾辛PKS區域 之DNA序列所組成，該區域係擇自於KS8、AT8、 DH8、KR8、ACP8、KS9、AT9、DH9、KR9、 ACP9、KS10、AT10、DH10、KR10、ACP10 和 TE10，此等分別對應於下面所示的序列辨識編號：6之 胺基酸序列 1-424、530-848、883-1070、1369- 1 552、 1648-1726 、 1749-2173 、 2287-2614 、 2640-2800 、 107 1237058 六 、申請專利範圍 3157-3341 3422-3500 、3534-3948 \ 4060-4390 、 4413-4597 、4900-5078 、5 172-5253和 5302-5555 : 序列辨識編號：6 Met Ala Asn Glu Glu Lys Leu Arg Glu Tyr Leu Lys Arg Val Val Val 1 5 10 15 Glu Leu Glu Glu Ala His Glu Arg Leu His Glu Leu Glu Arg Gin Glu 20 25 30 His Asp Pro lie Ala lie Val Ser Met Gly Cys Arg Tyr Pro Gly Gly 35 40 45 Val Ser Thr Pro Glu Glu Leu Trp Arg Leu Val Val Asp Gly Gly Asp 50 55 60 Ala lie Ala Asn Phe Pro Glu Asp Arg Gly Trp Asn Leu Asp Glu Leu 65 70 75 80 Phe Asp Pro Asp Pro Gly Arg Ala Gly Thr Ser Tyr Val Arg Glu Gly 85 90 95 Gly Phe Leu Arg Gly Val Ala Asp Phe Asp Ala Gly Leu Phe Gly He 100 105 110 Ser Pro Arg Glu Ala Gin Ala Met Asp Pro Gin Gin Arg Leu Leu Leu 115 120 125 Glu lie Ser Trp Glu Val Phe Glu Arg Ala Gly lie Asp Pro Phe Ser 130 135 140 Leu Arg Gly Thr Lys Thr Gly Val Phe Ala Gly Leu lie Tyr His Asp 145 150 155 160 Tyr Ala Ser Arg Phe Arg Lys Thr Pro Ala Glu Phe Glu Gly Tyr Phe 165 170 175 Ala Thr Gly Asn Ala Gly Ser Val Ala Ser Gly Arg Val Ala Tyr Thr 180 185 190 Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser 195 200 205 Ser Leu Val Ala Leu His Leu Ala Cys Gin Ser Leu Arg Leu Gly Glu 210 215 220 Cys Asp Leu Ala Leu Ala Gly Gly lie Ser Val Met Ala Thr Pro Gly 225 230 235 240 Ala Phe Val Glu Phe Ser Arg Gin Arg Ala Leu Ala Ser Asp Gly Arg 245 250 255 Cys Lys Pro Phe Ala Asp Ala Ala Asp Gly Thr Gly Trp Gly Glu Gly 260 265 270 Ala Gly Met Leu Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly 275 280 285
108 1237058 六 、申請專利範圍 His Pro Val Leu Ala Ala Val Val Gly Ser Ala lie Asn Gin Asp Gly 290 295 300 Thr Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gin Gin Arg Val 305 310 315 320 lie Arg Gin Ala Leu Ala Asn Ala Gly Leu Ser Pro Ala Glu Val Asp 325 330 335 Val Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro lie Glu 340 345 350 Ala Gin Ala Leu lie Ala Thr Tyr Gly Ala Asn Arg Ser Ala Asp His 355 360 365 Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn lie Gly His Thr Gin Ala 370 375 380 Ala Ala Gly Val Ala Gly Val lie Lys Ser Val Leu Ala lie Arg His 385 390 395 400 Arg Glu Met Pro Arg Ser Leu His lie Asp Gin Pro Ser Gin His Val 405 410 415 Asp Trp Ser Ala Gly Ala Val Arg Leu Leu Thr Asp Ser Val Asp Trp 420 425 430 Pro Asp Leu Gly Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Met 435 440 445 Ser Gly Thr Asn Ala His Leu lie Val Glu Glu Val Ser Asp Glu Pro 450 455 460 Val Ser Gly Ser Thr Glu Pro Thr Gly Ala Phe Pro Trp Pro Leu Ser 465 470 475 480 Gly Lys Thr Glu Thr Ala Leu Arg Glu Gin Ala Ala Glu Leu Leu Ser 485 490 495 Val Val Thr Glu His Pro Glu Pro Gly Leu Gly Asp Val Gly Tyr Ser 500 505 510 Leu Ala Thr Gly Arg Ala Ala Met Glu His Arg Ala Val Val Val Ala 515 520 525 Asp Asp Arg Asp Ser Phe Val Ala Gly Leu Thr Ala Leu Ala Ala Gly 530 535 540 Val Pro Ala Ala Asn Val Val Gin Gly Ala Ala Asp Cys Lys Gly Lys 545 550 555 560 Val Ala Phe Val Phe Pro Gly Gin Gly Ser His Trp Gin Gly Met Ala 565 570 575 Arg Glu Leu Ser Glu Ser Ser Pro Val Phe Arg Arg Lys Leu Ala Glu 580 585 590 Cys Ala Ala Ala Thr Ala Pro Tyr Val Asp Trp Ser Leu Leu Gly Val 595 600 605
109 1237058 六 、申請專利範圍 Leu Arg Gly Asp Pro Asp Ala Pro Ala Leu Asp Arg Asp Asp Val lie 610 615 620 Gin Leu Ala Leu Phe Ala Met Met Val Ser Leu Ala Glu Leu Trp Arg 625 630 635 640 Ser Cys Gly Val Glu Pro Ala Ala Val Val Gly His Ser Gin Gly Glu 645 650 655 lie Ala Ala Ala His Val Ala Gly Ala Leu Ser Leu Thr Asp Ala Val 660 665 670 Arg lie lie Ala Ala Arg Cys Asp Ala Val Ser Ala Leu Thr Gly Lys 675 680 685 Gly Gly Met Leu Ala lie Ala Leu Pro Glu Ser Ala Val Val Lys Arg 690 695 7 00 lie Ala Gly Leu Pro Glu Leu Thr Val Ala Ala Val Asn Gly Pro Gly 705 710 715 720 Ser Thr Val Val Ser Gly Glu Pro Ser Ala Leu Glu Arg Leu Gin Thr 725 730 735 Glu Leu Thr Ala Glu Asn Val Gin Thr Arg Arg Val Gly lie Asp Tyr 740 745 750 Ala Ser His Ser Pro Gin lie Ala Gin Val Gin Gly Arg Leu Leu Asp 755 760 765 Arg Leu Gly Glu Val Gly Ser Glu Pro Ala Glu lie Ala Phe Tyr Ser 77 0 Ί15 780 Thr Val Thr Gly Glu Arg Thr Asp Thr Gly Arg Leu Asp Ala Asp Tyr 7 85 7 90 795 800 Trp Tyr Gin Asn Leu Arg Gin Pro Val Arg Phe Gin Gin Thr Val Ala 805 810 815 Arg Met Ala Asp Gin Gly Tyr Arg Phe Phe Val Glu Val Ser Pro His 820 825 830 Pro Leu Leu Thr Ala Gly lie Gin Glu Thr Leu Glu Ala Ala Asp Ala 835 840 845 Gly Gly Val Val Val Gly Ser Leu Arg Arg Gly Glu Gly Gly Ser Arg 850 855 860 Arg Trp Leu Thr Ser Leu Ala Glu Cys Gin Val Arg Gly Leu Pro Val 865 870 875 880 Asn Trp Glu Gin Val Phe Leu Asn Thr Gly Ala Arg Arg Val Pro Leu 885 890 895 Pro Thr Tyr Pro Phe Gin Arg Gin Arg Tyr Trp Leu Glu Ser Ala Glu 900 905 910 Tyr Asp Ala Gly Asp Leu Gly Ser Val Gly Leu Leu Ser Ala Glu His 915 920 925
-110 - 1237058 六 、申請專利範圍 Pro Leu Leu Gly Ala Ala Val Thr Leu Ala Asp Ala Gly Gly Phe Leu 930 935 940 Leu Thr Gly Lys Leu Ser Val Lys Thr Gin Pro Trp Leu Ala Asp His 945 950 955 960 Val Val Gly Gly Ala lie Leu Leu Pro Gly Thr Ala Phe Val Glu Met 965 970 975 Leu lie Arg Ala Ala Asp Gin Val Gly Cys Asp Leu lie Glu Glu Leu 980 985 990 Ser Leu Thr Thr Pro Leu Val Leu Pro Ala Thr Gly Ala Val Gin Val 995 1000 1005 Gin lie Ala Val Gly Gly Pro Asp Glu Ala Gly Arg Arg Ser Val Arg 1010 1015 1020 Val His Ser Cys Arg Asp Asp Ala Val Pro Gin Asp Ser Trp Thr Cys 1025 1030 1035 1040 His Ala Thr Gly Thr Leu Thr Ser Ser Asp His Gin Asp Ala Gly Gin 1045 1050 1055 Gly Pro Asp Gly lie Trp Pro Pro Asn Asp Ala Val Ala Val Pro Leu 1060 1065 1070 Asp Ser Phe Tyr Ala Arg Ala Ala Glu Arg Gly Phe Asp Phe Gly Pro 1075 1080 1085 Ala Phe Gin Gly Leu Gin Ala Ala Trp Lys Arg Gly Asp Glu lie Phe 1090 1095 1100 Ala Glu Val Gly Leu Pro Thr Ala His Arg Glu Asp Ala Gly Arg Phe 1105 1110 1115 1120 Gly lie His Pro Ala Leu Leu Asp Ala Ala Leu Gin Ala Leu Gly Ala 1125 1130 1135 Ala Glu Glu Asp Pro Asp Glu Gly Trp Leu Pro Phe Ala Trp Gin Gly 1140 1145 1150 Val Ser Leu Lys Ala Thr Gly Ala Leu Ser Leu Arg Val His Leu Val 1155 1160 1165 Pro Ala Gly Ala Asn Ala Val Ser Val Phe Thr Thr Asp Thr Thr Gly 1170 1175 1180 Gin Ala Val Leu Ser lie Asp Ser Leu Val Leu Arg Gin lie Ser Asp 1185 1190 1195 1200 Lys Gin Leu Ala Ala Ala Arg Ala Met Glu His Glu Ser Leu Phe Arg 1205 1210 1215 Val Asp Trp Lys Arg He Ser Pro Gly Ala Ala Lys Pro Val Ser Trp 1220 1225 1230 Ala Val lie Gly Asn Asp Glu Leu Ala Arg Ala Cys Gly Ser Ala Leu 1235 1240 1245
111 1237058 六 、申請專利範圍 Gly Thr Glu Leu His Pro Asp Leu Thr Gly Leu Ala Asp Pro Pro Pro 1250 1255 1260 Asp Val Val Val Val Pro Cys Gly Ala Ser Arg Gin Asp Leu Asp Val 1265 1270 1275 1280 Ala Ser Glu Ala Arg Ala Ala Thr Gin Arg Met Leu Asp Leu lie Gin 1285 1290 1295 Asp Trp Leu Ala Ala Ala Arg Phe Ala Gly Ser Arg Leu Val Val Val 1300 1305 1310 Thr Cys Gly Ala Ala Ser Thr Gly Pro Ala Glu Gly Val Ser Asp Leu 1315 1320 1325 Val His Ala Ala Ser Trp Gly Leu Leu Arg Ser Ala Gin Ser Glu Asn 1330 1335 1340 Pro Asp Arg Phe Val Leu Val Asp Val Asp Gly Thr Ala Glu Ser Trp 1345 1350 1355 1360 Arg Ala Leu Ala Ala Ala Val Arg Ser Gly Glu Pro Gin Leu Ala Leu 1365 1370 1375 Arg Ala Gly Glu Val Arg Val Pro Arg Leu Ala Arg Cys Val Ala Ala 1380 1385 1390 Glu Asp Ser Arg lie Pro Val Pro Gly Ala Asp Gly Thr Val Leu lie 1395 1400 1405 Ser Gly Gly Thr Gly Leu Leu Gly Gly Leu Val Ala Arg His Leu Val 1410 1415 1420 Ala Glu Arg Gly Val Arg Arg Leu Val Leu Ala Gly Arg Arg Gly Trp 1425 1430 1435 1440 Ser Ala Pro Gly Val Thr Asp Leu Val Asp Glu Leu Val Gly Leu Gly 1445 1450 1455 Ala Ala Val Glu Val Ala Ser Cys Asp Val Gly Asp Arg Ala Gin Leu 1460 1465 1470 Asp Arg Leu Leu Thr Thr lie Ser Ala Glu Phe Pro Leu Arg Gly Val 1475 1480 1485 Val His Ala Ala Gly Ala Leu Ala Asp Gly Val Val Glu Ser Leu Thr 1490 1495 1500 Pro Glu His Val Ala Lys Val Phe Gly Pro Lys Ala Ala Gly Ala Trp 1505 1510 1515 1520 His Leu His Glu Leu Thr Leu Asp Leu Asp Leu Ser Phe Phe Val Leu 1525 1530 1535 Phe Ser Ser Phe Ser Gly Val Ala Gly Ala Ala Gly Gin Gly Asn Tyr 1540 1545 1550 Ala Ala Ala Asn Ala Phe Leu Asp Gly Leu Ala Gin His Arg Arg Thr 1555 1560 1565
-112 - 1237058 六 、申請專利範圍 Ala Gly Leu Pro Ala Val Ser Leu Ala Trp Gly Leu Trp Glu Gin Pro 1570 1575 1580 Ser Gly Met Thr Gly Ala Leu Asp Ala Ala Gly Arg Ser Arg lie Ala 1585 1590 1595 1600 Arg Thr Asn Pro Pro Met Ser Ala Pro Asp Gly Leu Arg Leu Phe Glu 1605 1610 1615 Met Ala Phe Arg Val Pro Gly Glu Ser Leu Leu Val Pro Val His Val 1620 1625 1630 Asp Leu Asn Ala Leu Arg Ala Asp Ala Ala Asp Gly Gly Val Pro Ala 1635 1640 1645 Leu Leu Arg Asp Leu Val Pro Ala Pro Val Arg Arg Ser Ala Val Asn 1650 1655 1660 Glu Ser Ala Asp Val Asn Gly Leu Val Gly Arg Leu Arg Arg Leu Pro 1665 16 70 1675 1680 Asp Leu Asp Gin Glu Thr Gin Leu Leu Gly Leu Val Arg Glu His Val 1685 1690 1695 Ser Ala Val Leu Gly His Ser Gly Ala Val Glu Val Gly Ala Asp Arg 17 00 1705 1710 Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Ser Gly Val Glu Phe Arg 1715 1720 1725 Asn Arg Leu Gly Gly Val Leu Gly Val Arg Leu Pro Ala Thr Ala Val 1730 1735 1740 Phe Asp Tyr Pro Thr Pro Arg Ala Leu Val Arg Phe Leu Leu Asp Lys 1745 1750 1755 1760 Leu lie Gly Gly Val Glu Ala Pro Thr Pro Ala Pro Ala Ala Val Ala 1765 177 0 1775 Ala Val Thr Ala Asp Asp Pro Val Val lie Val Gly Met Gly Cys Arg 1780 1785 17 90 Tyr Pro Gly Gly Val Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Ala 1795 1800 1805 Gly Gly Leu Asp Ala Val Ala Glu Phe Pro Asp Asp Arg Gly Trp Asp 1810 1815 1820 Gin Ala Gly Leu Phe Asp Pro Asp Pro Asp Arg Leu Gly Thr Ser Tyr 1825 1830 1835 1840 Val Cys Glu Gly Gly Phe Leu Arg Asp Ala Ala Glu Phe Asp Ala Gly 1845 1850 1855 Phe Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin 1860 1865 18 7 0 Arg Leu Leu Leu Glu Val Ala Trp Glu Thr Val Glu Arg Ala Gly lie 1875 1880 1885
113 1237058 六 、申請專利範圍 Asp Pro Leu Ser Leu Arg Gly Ser Arg Thr Gly Val Phe Ala Gly Leu 1890 1895 1900 Met His His Asp Tyr Gly Ala Arg Phe lie Thr Arg Ala Pro Glu Gly 1905 1910 1915 1920 Phe Glu Gly Tyr Leu Gly Asn Gly Ser Ala Gly Gly Val Phe Ser Gly 1925 1930 1935 Arg Val Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp 1940 1945 1950 Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gin Ala 1955 I960 1965 Leu Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val 1970 1975 1980 Met Ala Thr Pro Gly Met Phe Val Glu Phe Ser Arg Gin Arg Gly Leu 1985 1990 1995 2000 Ala Ala Asp Gly Arg Cys Lys Ser Phe Ala Ala Ala Ala Asp Gly Thr 2005 2010 2015 Gly Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp 2020 2025 2030 Ala Arg Arg Asn Gly His Ala Val Leu Ala Val Val Arg Gly Ser Ala 2035 2040 2045 Val Asn Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro 2050 2055 2060 Ser Gin Gin Arg Val He Thr Gin Ala Leu Ala Ser Ala Gly Leu Ser 2065 2070 2075 2080 Val Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu 2085 2090 2095 Gly Asp Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr Gly Gin Gly 2100 2105 2110 Arg Asp Ser Asp Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie 2115 2120 2125 Gly His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val 2130 2135 2140 Met Ala Met Arg His Gly Gin Leu Pro Ala Thr Leu His Val Asp Glu 2145 2150 2155 2160 Pro Thr Ser Glu Val Asp Trp Ser Ala Gly Asp Val Gin Leu Leu Thr 2165 217 0 2175 Glu Asn Thr Pro Trp Pro Gly Asn Ser His Pro Arg Arg Val Gly Val 2180 2185 2190 Ser Ser Phe Gly lie Ser Gly Thr Asn Ala His Val lie Leu Glu Gin 2195 2200 2205
114 1237058 六 、申請專利範圍 Ala Ser Lys Thr Pro Asp Glu Thr Ala Asp Lys Ser Gly Pro Asp Ser 2210 2215 2220 Glu Ser Thr Val Asp Leu Pro Ala Val Pro Leu lie Val Ser Gly Arg 2225 2230 2235 2240 Thr Pro Ala Ala Leu Ser Ala Gin Ala Ser Ala Leu Leu Ser Tyr Leu 2245 2250 2255 Gly Glu Arg Gly Asp lie Ser Thr Leu Asp Ala Ala Phe Ser Leu Ala 2260 2265 2270 Ser Ser Arg Ala Ala Leu Glu Glu Arg Ala Val Val Leu Gly Ala Asp 2275 2280 2285 Arg Glu Thr Leu Leu Ser Gly Leu Glu Ala Leu Ala Ser Gly Arg Glu 2290 2295 2300 Ala Ser Gly Val Val Ser Gly Ser Pro Val Ser Gly Gly Val Gly Phe 2305 2310 2315 2320 Val Phe Ala Gly Gin Gly Gly Gin Trp Leu Gly Met Gly Arg Gly Leu 2325 2330 2335 Tyr Ser Val Phe Pro Val Phe Ala Asp Ala Phe Asp Glu Ala Cys Ala 2340 2345 2350 Gly Leu Asp Ala His Leu Gly Gin Asp Val Gly Val Arg Asp Val Val 2355 2360 2365 Phe Gly Ser Asp Gly Ser Leu Leu Asp Arg Thr Leu Trp Ala Gin Ser 2370 2375 2380 Gly Leu Phe Ala Leu Gin Val Gly Leu Leu Ser Leu Leu Gly Ser Trp 2385 2390 2395 2400 Gly Val Arg Pro Gly Val Val Leu Gly His Ser Val Gly Glu Phe Ala 2405 2410 2415 Ala Ala Val Ala Ala Gly Val Leu Ser Leu Pro Asp Ala Ala Arg Met 2420 2425 2430 Val Ala Gly Arg Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Ala 2435 2440 2445 Met Leu Ala Val Ala Ala Gly Glu Glu Gin Leu Arg Pro Leu Leu Ala 2450 2455 2460 Asp Arg Val Asp Gly Ala Gly lie Ala Ala Val Asn Ala Pro Glu Ser 2465 2470 2475 2480 Val Val Leu Ser Gly Asp Arg Glu Val Leu Asp Asp lie Ala Gly Ala 2485 2490 2495 Leu Asp Gly Gin Gly He Arg Trp Arg Arg Leu Arg Val Ser His Ala 2500 2505 2510 Phe His Ser Tyr Arg Met Asp Pro Met Leu Gin Glu Phe Ala Glu He 2515 2520 2525
-115 - 1237058 六 、申請專利範圍 Ala Arg Ser Val Asp Tyr Arg Arg Gly Asp Leu Pro Val Val Ser Thr 2530 2535 2540 Leu Thr Gly Glu Leu Asp Thr Ala Gly Val Met Ala Thr Pro Glu Tyr 2545 2550 2555 2560 Trp Val Arg Gin Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Arg 2565 2570 2575 Val Leu Ala Gin Gin Gly Val Ala Thr lie Phe Glu Leu Gly Pro Asp 2580 2585 2590 Ala Thr Leu Ser Ala Leu lie Pro Asp Cys His Ser Trp Ala Asp Gin 2595 2600 2605 Ala Met Pro lie Pro Met Leu Arg Lys Asp Arg Thr Glu Thr Glu Thr 2610 2615 2620 Val Val Ala. Ala Val Ala Arg Ala His Thr Arg Gly Val Pro Val Glu 2625 2630 2635 2640 Trp Ser Ala Tyr Phe Ala Gly Thr Gly Ala Arg Arg Val Glu Leu Pro 2645 2650 2655 Thr Tyr Ala Phe Gin Arg Gin Arg Tyr Trp Leu Glu Thr Ser Asp Tyr 2660 2665 2670 Gly Asp Val Thr Gly lie Gly Leu Ala Ala Ala Glu His Pro Leu Leu 2675 2680 2685 Gly Ala Val Val Ala Leu Ala Asp Gly Asp Gly Met Val Leu Thr Gly 2690 2695 2700 Arg Leu Ser Val Gly Thr His Pro Trp Leu Ala Gin His Arg Val Leu 2705 2710 2715 2720 Gly Glu Val Val Val Pro Gly Thr Ala lie Leu Glu Met Ala Leu His 2 725 2730 2 735 Ala Gly Ala Arg Leu Gly Cys Asp Arg Val Glu Glu Leu Thr Leu Glu 2740 2745 2750 Thr Pro Leu Val Val Pro Glu Arg Ala Ala Gly Ala Gly Ser Arg Gly 2 755 2760 2765 Pro Ala Gly Gly Thr Thr Val Ser lie Glu Thr Ala Glu Glu Arg Val 2770 27 7 5 2 7 80 Arg Thr Asn Asp Ala lie Glu lie Gin Leu Leu Val Asn Ala Pro Asp 2 7 85 2790 2795 2800 Glu Gly Gly Arg Arg Arg Val Ser Leu Tyr Ser Arg Pro Ala Gly Gly 2805 2810 2815 Ser Arg Gly Gly Gly Trp Thr Arg His Ala Thr Gly Glu Leu Val Val 2820 2825 2830 Gly Thr Thr Gly Gly Arg Ala Val Pro Asp Trp Ser Ala Glu Gly Ala 2835 2840 2845
-116 - 1237058 六 、申請專利範圍 Glu Ser lie Ala Leu Asp Glu Phe Tyr Val Ala Leu Ala Gly Asn Gly 2850 2855 2860 Phe Glu Tyr Gly Pro Leu Phe Gin Gly Leu Gin Ala Ala Trp Arg Arg 2865 2870 2875 2880 Gly Asp Glu Val Leu Ala Glu lie Ala Pro Pro Ala Glu Ala Asp Ala 2885 2890 2895 Met Ala Ser Gly Tyr Leu Leu Asp Pro Ala Leu Leu Asp Ala Ala Leu 2900 2905 2910 Gin Ala Ser Ala Leu Gly Asp Arg Pro Glu Gin Gly Gly Ala Trp Leu 2915 2920 2925 Pro Phe Ser Phe Thr Gly Val Glu Leu Ser Ala Pro Ala Gly Thr lie 2930 2935 2940 Ser Arg Val Arg Leu Glu Thr Arg Arg Pro Asp Ala lie Ser Val Ala 2945 2950 2955 2 96 0 Val Met Asp Glu Ser Gly Arg Leu Leu Ala Ser lie Asp Ser Leu Arg 2965 2970 2975 Leu Arg Ser Val Ser Ser Gly Gin Leu Ala Asn Arg Asp Ala Val Arg 2980 2985 2990 Asp Ala Leu Phe Glu Val Thr Trp Glu Pro Val Ala Thr Gin Ser Thr 2995 3000 3005 Glu Pro Gly Arg Trp Ala Leu Leu Gly Asp Thr Ala Cys Gly Lys Asp 3010 3015 3020 Asp Leu lie Lys Leu Ala Thr Asp Ser Ala Asp Arg Cys Ala Asp Leu 3025 3030 3035 3040 Ala Ala Leu Ala Glu Lys Leu Asp Ser Ser Ala Leu Val Pro Asp Val 3045 3050 3055 Val Val Tyr Cys Ala Gly Glu Gin Ala Asp Pro Gly Thr Gly Ala Ala 3060 3065 3070 Ala Leu Ala Glu Thr Gin Gin Thr Leu Ala Leu Leu Gin Ala Trp Leu 3075 3080 3085 Ala Glu Pro Arg Leu Ala Glu Ala Arg Leu Val Val Val Thr Cys Ala 3090 3095 3100 Ala Val Thr Thr Ala Pro Ser Asp Gly Ala Ser Glu Leu Ala His Ala 3105 3110 3115 3120 Pro Leu Trp Gly Leu Leu Arg Ala Ala Gin Val Glu Asn Pro Gly Gin 3125 3130 3135 Phe Val Leu Ala Asp Val Asp Gly Thr Ala Glu Ser Trp Arg Ala Leu 3140 3145 3150 Pro Ser Ala Leu Gly Ser Met Glu Pro Gin Leu Ala Leu Arg Lys Gly 3155 3160 3165
-117 - 1237058 六 、申請專利範圍 Ala Val Arg Ala Pro Arg Leu Ala Ser Val Ala Gly Gin lie Asp Val 3170 3175 3180 Pro Ala Val Val Ala Asp Pro Asp Arg Thr Val Leu lie Ser Gly Gly 3185 3190 3195 3200 Thr Gly Leu Leu Gly Gly Ala Val Ala Arg His Leu Val Thr Glu Arg 3205 3210 3215 Gly Val Arg Arg Leu Val Leu Thr Gly Arg Arg Gly Trp Asp Ala Pro 3220 3225 3230 Gly He Thr Glu Leu Val Gly Glu Leu Asn Gly Leu Gly Ala Val Val 3235 3240 3245 Asp Val Val Ala Cys Asp Val Ala Asp Arg Ala Asp Leu Glu Ser Leu 3250 3255 3260 Leu Ala Ala Val Pro Ala Glu Phe Pro Leu Cys Gly Val Val His Ala 3265 3270 3275 3280 Ala Gly Ala Leu Ala Asp Gly Val lie Glu Ser Leu Ser Pro Asp Asp 3285 3290 3295 Val Gly Ala Val Phe Gly Pro Lys Ala Ala Gly Ala Trp Asn Leu His 3300 3305 3310 Glu Leu Thr Arg Asp Thr Asp Leu Ser Phe Phe Ala Leu Phe Ser Ser 3315 3320 3325 Leu Ser Gly Val Ala Gly Ala Pro Gly Gin Gly Asn Tyr Ala Ala Ala 3330 3335 3340 Asn Ala Phe Leu Asp Ala Leu Ala His Tyr Arg Arg Ser Gin Gly Leu 3345 3350 3355 3360 Pro Ala Val Ser Leu Ala Trp Gly Leu Trp Glu Gin Pro Ser Gly Met 3365 3370 3375 Thr Glu Thr Leu Ser Glu Val Asp Arg Ser Arg lie Ala Arg Ala Asn 3380 3385 3390 Pro Pro Leu Ser Thr Lys Glu Gly Leu Arg Leu Phe Asp Ala Gly Leu 3395 3400 3405 Ala Leu Asp Arg Ala Ala Val Val Pro Ala Lys Leu Asp Arg Thr Phe 3410 3415 3420 Leu Ala Glu Gin Ala Arg Ser Gly Ser Leu Pro Ala Leu Leu Thr Ala 3425 3430 3435 3440 Leu Val Pro Pro lie Arg Arg Asn Arg Arg Ala Ser Gly Thr Glu Leu 3445 3450 3455 Ala Asp Glu Gly Thr Leu Leu Gly Val Val Arg Glu His Ala Ala Ala 3460 3465 34 7 0 Val Leu Gly Tyr Ser Ser Ala Ala Asp Val Gly Val Glu Arg Ala Phe 34 75 3480 3485
118 1237058 六 、申請專利範圍 Arg Asp Leu Gly Phe Asp Ser Leu Ser Gly Val Glu Leu Arg Asn Arg 3490 3495 3500 Leu Ala Gly Val Leu Gly Val Arg Leu Pro Ala Thr Ala Val Phe Asp 3505 3510 3515 3520 Tyr Pro Thr Pro Arg Ala Leu Ala Arg Phe Leu His Gin Glu Leu Ala 3525 3530 3535 Asp Glu He Ala Thr Thr Pro Ala Pro Val Thr Thr Thr Arg Ala Pro 3540 3545 3550 Val Ala Glu Asp Asp Leu Val Ala lie Val Gly Met Gly Cys Arg Phe 3555 3560 3565 Pro Gly Gin Val Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Ala Gly 357 0 3575 3580 Gly Val Asp Ala Val Ala Asp Phe Pro Ala Asp Arg Gly Trp Asp Leu 3585 3590 3595 3600 Ala Gly Leu Phe Asp Pro Asp Pro Glu Arg Ala Gly Lys Thr Tyr Val 3605 3610 3615 Arg Glu Gly Ala Phe Leu Thr Asp Ala Asp Arg Phe Asp Ala Gly Phe 3620 3625 3630 Phe Gly lie Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gin Gin Arg 3635 3640 3645 Leu Leu Leu Glu Leu Ser Trp Glu Ala lie Glu Arg Ala Gly lie Asp 3650 3655 3660 Pro Gly Ser Leu Arg Gly Ser Arg Thr Gly Val Phe Ala Gly Leu Met 3665 3670 3675 3680 Tyr His Asp Tyr Gly Ala Arg Phe Ala Ser Arg Ala Pro Glu Gly Phe 3685 3690 3695 Glu Gly Tyr Leu Gly Asn Gly Ser Ala Gly Ser Val Ala Ser Gly Arg 3700 3705 3710 lie Ala Tyr Ser Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr 3715 3720 3725 Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gin Ser Leu 3730 3735 3740 Arg Ser Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met 3745 3 7 50 3755 3760 Ser Thr Pro Gly Thr Phe Val Glu Phe Ser Arg Gin Arg Gly Leu Ala 3 765 3770 3 7 75 Pro Asp Gly Arg Cys Lys Ser Phe Ala Glu Ser Ala Asp Gly Thr Gly 3 7 80 3785 3 7 90 Trp Gly Glu Gly Ala Gly Leu Val Leu Leu Glu Arg Leu Ser Asp Ala 3795 3800 3805
-119 - 1237058 六 、申請專利範圍 Arg Arg Asn Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val 3810 3815 3820 Asn Gin Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser 3825 3830 3835 3840 Gin Gin Arg Val lie Gin Gin Ala Leu Ala Ser Ala Gly Leu Ser Val 3845 3850 3855 Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly 3860 3865 3870 Asp Pro lie Glu Ala Gin Ala Leu lie Ala Thr Tyr Gly Arg Asp Arg 38 75 3880 3885 Asp Pro Gly Arg Pro Leu Trp Leu Gly Ser Val Lys Ser Asn lie Gly 3890 3895 3900 His Thr Gin Ala Ala Ala Gly Val Ala Gly Val lie Lys Met Val Met 3905 3910 3915 3920 Ala Met Arg His Gly Gin Leu Pro Arg Thr Leu His Val Asp Ala Pro 3925 3930 3935 Ser Ser Gin Val Asp Trp Ser Ala Gly Arg Val Gin Leu Leu Thr Glu 3940 3945 3950 Asn Thr Pro Trp Pro Asp Ser Gly Arg Pro Cys Arg Val Gly Val Ser 3955 3960 3965 Ser Phe Gly lie Ser Gly Thr Asn Ala His Val lie Leu Glu Gin Ser 39 7 0 3975 3980 Thr Gly Gin Met Asp Gin Ala Ala Glu Pro Asp Ser Ser Pro Val Leu 3985 3990 3995 4000 Asp Val Pro Val Val Pro Trp Val Val Ser Gly Lys Thr Pro Glu Ala 4005 4010 4015 Leu Ser Ala Gin Ala Ala Thr Leu Ala Thr Tyr Leu Asp Gin Asn Val 4020 4025 4030 Asp Val Ser Pro Leu Asp Val Gly He Ser Leu Ala Val Thr Arg Ser 4035 4040 4045 Ala Leu Asp Glu Arg Ala Val Val Leu Gly Ser Asp Arg Asp Thr Leu 4050 4055 4060 Leu Ser Gly Leu Asn Ala Leu Ala Ala Gly His Glu Ala Ala Gly Val 4065 4070 40 75 4080 Val Thr Gly Pro Val Gly lie Gly Gly Arg Thr Gly Phe Val Phe Ala 4085 4090 4095 Gly Gin Gly Gly Gin Trp Leu Gly Met Gly Arg Arg Leu Tyr Ser Glu 4100 4105 4110 Phe Pro Ala Phe Ala Gly Ala Phe Asp Glu Ala Cys Ala Glu Leu Asp 4115 4120 4125
120 1237058 -Λ-/ \ 、申請專利範圍 Ala Asn Leu Gly Arg Glu Val Gly Val Arg Asp Val Val Phe Gly Ser 4130 4135 4140 Asp Glu Ser Leu Leu Asp Arg Thr Leu Trp Ala Gin Ser Gly Leu Phe 4145 4150 4155 4160 Ala Leu Gin Val Gly Leu Trp Glu Leu Leu Gly Thr Trp Gly Val Arg 4165 4170 4175 Pro Ser Val Val Leu Gly His Ser Val Gly Glu Leu Ala Ala Ala Phe 4180 4185 4190 Ala Ala Gly Val Leu Ser Met Ala Glu Ala Ala Arg Leu Val Ala Gly 4195 4200 4205 Arg Ala Arg Leu Met Gin Ala Leu Pro Ser Gly Gly Ala Met Leu Ala 4210 4215 4220 Val Ser Ala Thr Glu Ala Arg Val Gly Pro Leu Leu Asp Gly Val Arg 4225 4230 4235 4240 Asp Arg Val Gly Val Ala Ala Val Asn Ala Pro Gly Ser Val Val Leu 4245 4250 4255 Ser Gly Asp Arg Asp Val Leu Asp Gly lie Ala Gly Arg Leu Asp Gly 4260 4265 4270 Gin Gly lie Arg Ser Arg Trp Leu Arg Val Ser His Ala Phe His Ser 4275 4280 4285 His Arg Met Asp Pro Met Leu Ala Glu Phe Ala Glu Leu Ala Arg Ser 4290 4295 4300 Val Asp Tyr Arg Ser Pro Arg Leu Pro lie Val Ser Thr Leu Thr Gly 4305 4310 4315 4320 Asn Leu Asp Asp Val Gly Val Met Ala Thr Pro Glu Tyr Trp Val Arg 4325 4330 4335 Gin Val Arg Glu Pro Val Arg Phe Ala Asp Gly Val Gin Ala Leu Val 4340 4345 4350 Asp Gin Gly Val Asp Thr lie Val Glu Leu Gly Pro Asp Gly Ala Leu 4355 4360 4365 Ser Ser Leu Val Gin Glu Cys Val Ala Glu Ser Gly Arg Ala Thr Gly 4370 4375 4380 lie Pro Leu Val Arg Arg Asp Arg Asp Glu Val Arg Thr Val Leu Asp 4385 4390 4395 4400 Ala Leu Ala Gin Thr His Thr Arg Gly Gly Ala Val Asp Trp Gly Ser 4405 4410 4415 Phe Phe Ala Gly Thr Arg Ala Thr Gin Val Asp Leu Pro Thr Tyr Ala 4420 4425 4430 Phe Gin Arg Gin Arg Tyr Trp Leu Glu Pro Ser Asp Ser Gly Asp Val 4435 4440 4445
-121 - 1237058 六 、申請專利範圍 Thr Gly Val Gly Leu Thr Gly Ala Glu His Pro Leu Leu Gly Ala Val 4450 4455 4460 Val Pro Val Ala Gly Gly Asp Glu Val Leu Leu Thr Gly Arg Leu Ser 4465 4470 4475 4480 Val Gly Thr His Pro Trp Leu Ala Glu His Arg Val Leu Gly Glu Val 4485 4490 4495 Val Val Pro Gly Thr Ala Leu Leu Glu Met Ala Trp Arg Ala Gly Ser 4500 4505 4510 Gin Val Gly Cys Glu Arg Val Glu Glu Leu Thr Leu Glu Ala Pro Leu 4515 4520 4525 Val Leu Pro Glu Arg Gly Ala Ala Ala Val Gin Leu Ala Val Gly Ala 4530 4535 4540 Pro Asp Glu Ala Gly Arg Arg Ser Leu Gin Leu Tyr Ser Arg Gly Ala 4545 4550 4555 4560 Asp Glu Asp Gly Asp Trp Arg Arg lie Ala Ser Gly Leu Leu Ala Gin 4565 4570 4575 Ala Asn Ala Val Pro Pro Ala Asp Ser Thr Ala Trp Pro Pro Asp Gly 4580 4585 4590 Ala Gly Gin Val Asp Leu Ala Glu Phe Tyr Glu Arg Leu Ala Glu Arg 4595 4600 4605 Gly Leu Thr Tyr Gly Pro Val Phe Gin Gly Leu Arg Ala Ala Trp Arg 4610 4615 4620 His Gly Asp Asp lie Phe Ala Glu Leu Ala Gly Ser Pro Asp Ala Ser 4625 4630 4635 4640 Gly Phe Gly lie His Pro Ala Leu Leu Asp Ala Ala Leu His Ala Met 4645 4650 4655 Ala Leu Gly Ala Ser Pro Asp Ser Glu Ala Arg Leu Pro Phe Ser Trp 4660 4665 4670 Arg Gly Ala Gin Leu Tyr Arg Ala Glu Gly Ala Ala Leu Arg Val Arg 46 75 4680 4685 Leu Ser Pro Leu Gly Ser Gly Ala Val Ser Leu Thr Leu Val Asp Ala 4690 4695 4 7 00 Thr Gly Arg Arg Val Ala Ala Val Glu Ser Leu Ser Thr Arg Pro Val 4705 4710 4715 4 720 Ser Thr Asp Gin He Gly Ala Gly Arg Gly Asp Gin Glu Arg Leu Leu 4725 4730 4735 His Val Glu Trp Val Arg Ser Ala Glu Ser Ala Gly Met Ser Leu Thr 4740 4745 4750 Ser Cys Ala Val Val Gly Leu Gly Glu Pro Glu Trp His Ala Ala Leu 4 7 55 4 760 4765
122 1237058 /、 、申請專利範圍 Lys Thr Thr Gly Val Gin Val Glu Ser His Ala Asp Leu Ala Ser Leu 4770 4775 4 7 80 Ala Thr Glu Val Ala Lys Arg Gly Ser Ala Pro Gly Ala Val lie Val 4785 4790 4795 4800 Pro Cys Pro Arg Pro Arg Ala Met Gin Glu Leu Pro Thr Ala Ala Arg 4805 4810 4815 Arg Ala Thr Gin Gin Ala Met Ala Met Leu Gin Gin Trp Leu Ala Asp 4820 4825 4830 Asp Arg Phe Val Ser Thr Arg Leu lie Leu Leu Thr His Arg Ala Val 4835 4840 4845 Ser Ala Val Ala Gly Glu Asp Val Leu Asp Leu Val His Ala Pro Leu 4850 4855 4860 Trp Gly Leu Val Arg Ser Ala Gin Ala Glu His Pro Asp Arg Phe Ala 4865 4870 4875 4880 Leu lie Asp Met Asp Asp Glu Arg Ala Ser Gin Thr Ala Leu Ala Glu 4885 4890 4895 Ala Leu Thr Ala Gly Glu Ala Gin Leu Ala Val Arg Ser Gly Val Val 4900 4905 4910 Leu Ala Pro Arg Leu Gly Gin Val Lys Val Ser Gly Gly Glu Ala Phe 4915 4920 4925 Arg Trp Asp Glu Gly Thr Val Leu Val Thr Gly Gly Thr Gly Gly Leu 4930 4935 4940 Gly Ala Leu Leu Ala Arg His Leu Val Ser Ala His Gly Val Arg His 4945 4950 4955 4960 Leu Leu Leu Ala Ser Arg Arg Gly Leu Ala Ala Pro Gly Ala Asp Glu 4965 4970 4975 Leu Val Ala Glu Leu Glu Gin Ala Gly Ala Asp Val Ala Val Val Ala 4980 4985 4990 Cys Asp Ser Ala Asp Arg Asp Ser Leu Ala Arg Leu Val Ala Ser Val 4995 5000 5005 Pro Ala Glu Asn Pro Leu Arg Val Val Val His Ala Ala Gly Val Leu 5010 5015 5020 Asp Asp Gly Val Leu Met Ser Met Ser Pro Glu Arg Leu Asp Ala Val 5025 5030 5035 5040 Leu Arg Pro Lys Val Asp Ala Ala Trp Tyr Leu His Glu Leu Thr Arg 5045 5050 5055 Glu Leu Gly Leu Ser Ala Phe Val Leu Phe Ser Ser Val Ala Gly Leu 5060 5065 5070 Phe Gly Gly Ala Gly Gin Ser Asn Tyr Ala Ala Gly Asn Ala Phe Leu 5075 5080 5085
1237058 六 、申請專利範圍 Asp Ala Leu Ala His Cys Arg Gin Ala Gin Gly Leu Pro Ala Leu Ser 5090 5095 5100 Leu Ala Ser Gly Leu Trp Ala Ser lie Asp Gly Met Ala Gly Asp Leu 5105 5110 5115 5120 Ala Ala Ala Asp Val Glu Arg Leu Ser Arg Ala Gly lie Gly Pro Leu 5125 5130 5135 Ser Ala Pro Gly Gly Leu Ala Leu Phe Asp Ala Ala Val Gly Ser Asp 5140 5145 5150 Glu Pro Leu Leu Ala Pro Val Arg Leu Asp Val Glu Ala Leu Arg Val 5155 5160 5165 Gin Ala Arg Ser Val Gin Thr Arg lie Pro Glu Met Leu His Gly Met 5170 5175 5180 Ala Met Gly Pro Ser Arg Arg Thr Pro Phe Thr Ser Arg Val Glu Pro 5185 5190 5195 5200 Leu His Glu Arg Leu Ala Gly Leu Ser Glu Gly Glu Arg Arg Gin Gin 5205 5210 5215 Val Leu Gin Arg Val Arg Ala Asp lie Ala Val Val Leu Gly His Gly 5220 5225 5230 Arg Ser Ser Asp Val Asp lie Glu Lys Pro Leu Ala Glu Leu Gly Phe 5235 5240 5245 Asp Ser Leu Thr Ala lie Glu Leu Arg Asn Arg Leu Ala Thr Ala Thr 5250 5255 5260 Gly Leu Arg Leu Pro Ala Thr Leu Ala Phe Asp His Gly Thr Ala Ala 5265 5270 52 75 5280 Ala Leu Ala Gin His Val Cys Ala Gin Leu Gly Thr Ala Thr Ala Pro 5285 5290 5295 Ala Pro Arg Arg Thr Asp Asp Asn Asp Ala Thr Glu Pro Val Arg Ser 5300 5305 5310 Leu Phe Gin Gin Ala Tyr Ala Ala Gly Arg He Leu Asp Gly Met Asp 5315 5320 5325 Leu Val Lys Val Ala Ala Gin Leu Arg Pro Val Phe Gly Ser Pro Gly 5330 5335 5340 Glu Leu Glu Ser Leu Pro Lys Pro Val Gin Leu Ser Arg Gly Pro Glu 5345 5350 5355 5360 Glu Leu Ala Leu Val Cys Met Pro Ala Leu lie Gly Met Pro Pro Ala 5365 5370 53 75 Gin Gin Tyr Ala Arg lie Ala Ala Gly Phe Arg Asp Val Arg Asp Val 5380 5385 5390 Ser Val lie Pro Met Pro Gly Phe lie Ala Gly Glu Pro Leu Pro Ser 5395 5400 5405
124 1237058 六、申請專利範圍 Ala lie Glu Val Ala Val Arg Thr Gin Ala Glu Ala Val Leu Gin Glu 5410 5415 5420 Phe Ala Gly Gly Ser Phe Val Leu Val Gly His Ser Ser Gly Gly Trp 5425 5430 5435 5440 Leu Ala His Glu Val Ala Gly Glu Leu Glu Arg Arg Gly Val Val Pro 5445 5450 5455 Ala Gly Val Val Leu Leu Asp Thr Tyr lie Pro Gly Glu lie Thr Pro 5460 5465 5470 Arg Phe Ser Val Ala Met Ala His Arg Thr Tyr Glu Lys Leu Ala Thr 5475 5480 5485 Phe Thr Asp Met Gin Asp Val Gly lie Thr Ala Met Gly Gly Tyr Phe 5490 5495 5500 Arg Met Phe Thr Glu Trp Thr Pro Thr Pro lie Gly Ala Pro Thr Leu 5505 5510 5515 5520 Phe Val Arg Thr Glu Asp Cys Val Ala Asp Pro Glu Gly Arg Pro Trp 5525 5530 5535 Thr Asp Asp Ser Trp Arg Pro Gly Trp Thr Leu Ala Asp Ala Thr Val 5540 5545 5550 Gin Val Pro Gly Asp His Phe Ser Met Met Asp Glu His Ala Gly Ser 5555 5560 5565 Thr Ala Gin Ala Val Ala Ser Trp Leu Asp Lys Leu Asn Gin Arg Thr 5570 5575 5580 Ala Arg Gin Arg 5585 ° 12.如申請專利範圍第11項之分離DNA分子，其中該DNA序 列係擇自於由下列所構成之群組：如申請專利範圍第2項 中所示的序列辨識編號：1之鹼基59902-61 173、 61489-62445 > 62548-63111 > 64006-64557 > 64843-65079 ' 65146-66420 ^ 66760-67743 > 67819- 68301 - 69370-69924 > 70165-70401 - 70471- 71745 、 72079-73071 、 73138-73692 、 74599- 75135 、 75415-75660和75805-76566 。
125 1237058 六、申請專利範圍 13·種刀離的DNA分子，其由一個編碼史賓諾辛pKS模組 之DN A序列所組成，其中該模組係擇自於由下列所構成 之群組·如申请專利範圍第i項中所示的序列辨識編號： 2之胺基酸序列6-1413、如申請專利範圍第】項中所示的 序列辨識編號·· 2之胺基酸序列1525-25 13、如申請專利 範圍第1項中所示的序列辨識編號：3之胺基酸序列1 一 2034、如申請專利範圍第工項中所示的序列辨識編號：4 之胺基酸序列1-1506、如申請專利範圍第i項中所示的 序列辨識編號：4之胺基酸序列丨529-3053、如申請專利 範圍第1項中所示的序列辨識編號·· 5之胺基酸序列j _ 1 726、如申請專利範圍第1項中所示的序列辨識編號：5 之胺基酸序列1748-3 2 69、如申請專利範圍第}項中所示 的序列辨識編號：5之胺基酸序列329 1-4806、如申請專 利範圍第1項中所示的序列辨識編號：5之胺基酸序列h 1726、如申請專利範圍第^項中所示的序列辨識編號： 6之胺基酸序列1-1 7 2 6、如申請專利範圍第11項中所示 的序列辨識編號：6之胺基酸序列1749-3500和序列辨識 編號：6之胺基酸序列35434-5555。 14·如申請專利範圍第13項之分離DNA分子，其中該DNA序 列係擇自於由下列所構成之群組：如申請專利範圍第2項 中所示的序列辨識編號：1之鹼基21 126-2404 1、 24102-28649 、 29024-35125 、 35518-40035 、 40102-44676 、 45077-50254 ^ 50318-54883 > 54947-59494 、59902-65079 、65 146-70401 和 70471 -76566 ° 126 1237058 --------- 六、申請專利範圍 K -種增量地生產史賓諾辛之方法，其包含下面的步驟· 1)以-重組型DNA載體或其部份來轉形一微生物，古亥 j生物II由一生物合成途徑會生產史賓諾辛或史賓 諾辛前驅物，該載體或其部份包含有一如申請專利 範圍第1項之DNA序列，該DNA序列編碼一在該途 徑中係為速率限制的活性之表現；以及 2)在適合細胞生長和分裂、該DNA序列之表現以及生 產史賓諾辛之條件下，培養為該載體所轉形之該微 生物， 其中該步驟1)包含以-載體或其部份來轉形該微生物，該載 體或其部分包含一編碼史賓多泡酵母菌糾和史賓多泡酵母菌 幺以之DNA序列。 16.種&里地生產史賓語辛之方法，其包含下面的步驟： 1) 以一重組型DNA載體或其部份來轉形一微生物， 该微生物藉由一生物合成途徑會生產史賓諾辛或史賓諾 辛箣驅物，忒載體或其部份包含有一如申請專利範圍第1 項之DNA序列，該DNA序列編碼一在該途徑中係為速率 限制的活性之表現；以及 2) 在適合細胞生長和分裂、該DNA序列之表現以及 生產史賓諾辛之條件下，培養為該載體所轉形之該微生 物， 其中於該步驟1)中得到一經轉形的微生物，其中該經轉 形的微生物的基因組内至少有一擇自於、 SpnC、spnD、spnE、spnF、spnG、spnH、spnl、 spnJ、spnK、spnL、spnM、spnN、spn〇、spnp、 127 1237058 六、申請專利範圍 树、^、叫、史賓多泡酵母菌糾、史賓多泡酵 ::f、史賓多泡酵母菌㈣史賓多泡酵母菌〜的史 黄6右辛生物合成基因被複製。 i7.=申請專利範圍第16項之方法，其中於該步驟”中得到 -經轉形的微生物，其中該經轉形的微生物的基因组内 之史賓多泡酵母菌糾、史賓多泡酵母菌州和史賓多泡 酵母菌Are被複製。 !8·如申請專利範圍第16項之方法，其中於該步則）中得到 —經轉形的微生物，其中該經轉形的微生物的基因組内 之史賓多泡酵母菌糾和史賓多泡酵母菌㈣被複製。 種增量地來生產史賓諾辛之方法’其包含下面的步 驟： Ο，以一重組型DNA載體或其部份來轉形一微生物， 該微生物藉由一生物合成途徑會生產史賓諾辛或史賓諾 辛前驅物，該載體或其部份包含有一如申請專利範圍第工 項之DNA序列，該DNA序列編碼一在該途徑中係為速率 限制的活性之表現；以及 2) 在適合細胞生長和分裂、該DNA序列之表現以及 生產史賓諾辛之條件下，培養為該載體所轉形之該微生 物， 其中於該步驟1)中得到一經轉形的微生物，其中於該經 轉形的微生物的基因組内涉及該史賓諾辛生物合成途徑 之基因g中至少有一者藉由以該基因之一内部片段來重 組而被破壞，而其餘基因可作用而生產出一種史賓諾 128 1237058 申請專利範圍 辛，该史賓，右辛非為於假若該被破壞的基因有作用時被 生產出的史賓諾辛。 20. -種增量地生產史賓諾辛之方法，其包含下面的步驟： 1) 卩重組型DN A載體或其部份來轉形-微生物， 該微生物藉由-生物合成途徑會生產史賓諾辛或史㈣ 辛前驅物，該載體或其部份包含有一如申請專利範圍第】 項之DNA序列，該DNA序列編碼一在該途徑中係為速率 限制的活性之表現；以及 2) 在適合細胞生長和分裂、該DNA序列之表現以及 生產史賓料之條件下，培養為該載體所卿之該微生 物， 其中於該步驟1)中得到—經轉形的微生物，而該微生物 在其基因組内含有包括多個PKS模組之有作用的史賓諾 辛生物合成基因，其中該等基因：a)包含至少一個有作 用的PKS模組要比如申請專利範圍第2項中所示的序列辨 識編號：1中所存在者為多或者至少少一個；包含一 個PKS模組不同於申請專利範圍第2項中所*的序列辨識 、·扁號、1中所述之對應模組，而該不同係藉由、DH或 ER區域之刪除、去活化或加入或是藉由一會設定一不同 的羧酸之AT區域的取代所致。 21·—種分離大環内酯物生物合成基因之方法，其包含建立 一個生產大環内酯物的微生物之基因庫，以及使用申請專利 範圍第2項中所示的序觸識編號：1、序雜識編號：25、 序列辨識編號：28或序列辨識編號：32之一個至少有2〇個 129 1237058 六、申請專利範圍 鹼基長的標誌片段作為一雜交探針，其中該微生物係為一生 產史賓諾辛之微生物。
130
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