TWI231759B - Olopatadine formulations for topical administration - Google Patents

Olopatadine formulations for topical administration Download PDF

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Publication number
TWI231759B
TWI231759B TW091113234A TW91113234A TWI231759B TW I231759 B TWI231759 B TW I231759B TW 091113234 A TW091113234 A TW 091113234A TW 91113234 A TW91113234 A TW 91113234A TW I231759 B TWI231759 B TW I231759B
Authority
TW
Taiwan
Prior art keywords
solution
item
composition
acid
clarification
Prior art date
Application number
TW091113234A
Other languages
English (en)
Chinese (zh)
Inventor
Ernesto J Castillo
Wesley Wehsin Han
Huixiang Zhang
Hareshg Bhagat
Onkar N Singh
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23162841&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI231759(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Inc filed Critical Alcon Inc
Application granted granted Critical
Publication of TWI231759B publication Critical patent/TWI231759B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW091113234A 2001-06-27 2002-06-18 Olopatadine formulations for topical administration TWI231759B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30131501P 2001-06-27 2001-06-27

Publications (1)

Publication Number Publication Date
TWI231759B true TWI231759B (en) 2005-05-01

Family

ID=23162841

Family Applications (1)

Application Number Title Priority Date Filing Date
TW091113234A TWI231759B (en) 2001-06-27 2002-06-18 Olopatadine formulations for topical administration

Country Status (20)

Country Link
US (2) US6995186B2 (enExample)
EP (1) EP1399127B1 (enExample)
JP (5) JP4827374B2 (enExample)
KR (1) KR100884711B1 (enExample)
CN (1) CN1211125C (enExample)
AR (1) AR034619A1 (enExample)
AT (1) ATE295149T1 (enExample)
AU (1) AU2002310461B2 (enExample)
BR (1) BRPI0210707B8 (enExample)
CA (1) CA2447924C (enExample)
DE (1) DE60204142T2 (enExample)
DK (1) DK1399127T3 (enExample)
ES (1) ES2238574T3 (enExample)
GC (1) GC0000397A (enExample)
MX (1) MXPA03011947A (enExample)
PL (1) PL205565B1 (enExample)
PT (1) PT1399127E (enExample)
TW (1) TWI231759B (enExample)
WO (1) WO2003002093A1 (enExample)
ZA (1) ZA200308771B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI427052B (zh) * 2005-09-30 2014-02-21 Johnson & Johnson Vision Care 穩定眼科組成物之方法

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US7977376B2 (en) 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
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CN1942173B (zh) * 2004-04-08 2012-05-09 协和发酵麒麟株式会社 稳定性提高的固体制剂及其制造方法
US20070225356A1 (en) * 2004-04-21 2007-09-27 Kyowa Hakko Kogo Co., Ltd Preventive and/or Therapeutic Agent for Chronic Sinusitis
AU2005259911A1 (en) * 2004-06-28 2006-01-12 Alcon, Inc. Topical formulations for treating allergic diseases
AU2005309951B2 (en) * 2004-11-24 2011-07-07 Alcon, Inc. Method of delivering nasal spray
WO2006097458A1 (en) * 2005-03-15 2006-09-21 Nycomed Gmbh Novel combination
EP1901708B1 (en) 2005-07-08 2013-09-11 Senju Pharmaceutical Co., Ltd. Percutaneously absorptive ophthalmic preparation comprising olopatadine
US20080114076A1 (en) * 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
ZA200902587B (en) 2006-11-09 2010-06-30 Alcon Res Ltd Water insoluble polymer matrix for drug delivery
JP5323720B2 (ja) * 2006-12-18 2013-10-23 アルコン リサーチ， リミテッド 眼用薬物送達のためのデバイスおよび方法
WO2008093358A2 (en) * 2007-01-29 2008-08-07 Sun Pharmaceutical Industries Limited Aqueous topical solution containing olopatadine
HUE026162T2 (en) * 2007-02-07 2016-05-30 Novartis Ag Olopatadine preparation for topical nasal administration
WO2008120249A1 (en) * 2007-03-30 2008-10-09 Sifi S.P.A. Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use
US20080254029A1 (en) * 2007-04-11 2008-10-16 Alcon Research, Ltd. Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis
US20100227917A1 (en) * 2007-09-06 2010-09-09 Masashi Nakakura EYE DROP CONTAINING DIBENZ[b,e]OXEPIN DERIVATIVE
WO2009142950A1 (en) * 2008-05-19 2009-11-26 Alcon Research, Ltd. Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer
CN102089039B (zh) * 2008-08-26 2013-10-23 博磊科技股份有限公司 带静电荷口罩过滤产品和用于增加过滤效率的方法
JP2012509250A (ja) * 2008-08-28 2012-04-19 トルテック コーポレーション 抗ヒスタミン及び抗ヒスタミン様経鼻適用製品及び方法
US9458198B1 (en) 2009-06-26 2016-10-04 Shire Orphan Therapies Gmbh Cyclic peptide-based NPR-B agonists
PT2453872E (pt) * 2009-07-17 2013-10-30 Alcon Res Ltd Regime de pulverização nasal de olopatadina para crianças
WO2011027322A1 (en) 2009-09-03 2011-03-10 Ranbaxy Laboratories Limited Extended release dosage form containing olopatadine for oral administration
US8551938B2 (en) * 2009-09-25 2013-10-08 Alcon Research, Ltd. NPR-B agonists
UY32902A (es) 2009-09-25 2011-02-28 Alcon Res Ltd Nuevos agonistas de npr-b
CN102548536A (zh) * 2009-10-01 2012-07-04 爱尔康研究有限公司 奥洛他定组合物及其用途
AR078446A1 (es) 2009-12-18 2011-11-09 Alcon Res Ltd Agonistas de npr-b. uso.
WO2011075471A2 (en) 2009-12-18 2011-06-23 Alcon Research, Ltd. Novel npr-b agonists and methods of use for the treatment of c-type natriuretic peptide-mediated disorders
CN103140215A (zh) * 2010-07-21 2013-06-05 爱尔康研究有限公司 具有提高的溶解度特征的药物组合物
WO2012063237A2 (en) * 2010-11-08 2012-05-18 Healor Ltd. Buffered ophthalmic compositions and methods of use thereof
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
CN102885767A (zh) * 2012-11-02 2013-01-23 江苏吉贝尔药业有限公司 一种新的盐酸奥洛他定滴眼液及其制备方法
WO2018144742A1 (en) 2017-02-01 2018-08-09 Shire Human Genetic Therapies, Inc. Compounds and compositions for the treatment of ophthalmic disorders
WO2018235935A1 (ja) * 2017-06-23 2018-12-27 参天製薬株式会社 水溶性粘稠化剤を含有する医薬組成物
JP7037349B2 (ja) * 2017-06-23 2022-03-16 参天製薬株式会社 水溶性粘稠化剤を含有する医薬組成物
CN114980881A (zh) * 2019-12-06 2022-08-30 东兴药品工业株式会社 包含奥洛他定的鼻用组合物
KR102705675B1 (ko) * 2020-03-31 2024-09-11 산텐 세이야꾸 가부시키가이샤 수지제 용기에 충전된 은염 함유 안과용 수성 조성물
CN111700860A (zh) * 2020-07-09 2020-09-25 浙江尖峰药业有限公司 盐酸奥洛他定滴眼液及其制备方法
CN119318630B (zh) * 2024-10-16 2025-08-22 苏州欧康维视生物科技有限公司 一种阿托品药物组合物

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI427052B (zh) * 2005-09-30 2014-02-21 Johnson & Johnson Vision Care 穩定眼科組成物之方法

Also Published As

Publication number Publication date
WO2003002093A1 (en) 2003-01-09
KR20040025919A (ko) 2004-03-26
US6995186B2 (en) 2006-02-07
US20030055102A1 (en) 2003-03-20
US7402609B2 (en) 2008-07-22
CN1525849A (zh) 2004-09-01
CN1211125C (zh) 2005-07-20
ATE295149T1 (de) 2005-05-15
PL205565B1 (pl) 2010-05-31
AU2002310461B2 (en) 2006-05-18
PL367780A1 (en) 2005-03-07
JP2012107046A (ja) 2012-06-07
KR100884711B1 (ko) 2009-02-19
GC0000397A (en) 2007-03-31
ZA200308771B (en) 2005-01-26
DE60204142T2 (de) 2005-10-06
AR034619A1 (es) 2004-03-03
JP2009114213A (ja) 2009-05-28
EP1399127B1 (en) 2005-05-11
BR0210707A (pt) 2004-07-20
BRPI0210707B8 (pt) 2021-05-25
CA2447924C (en) 2009-11-03
HK1059573A1 (en) 2004-07-09
JP4827374B2 (ja) 2011-11-30
JP2004536096A (ja) 2004-12-02
ES2238574T3 (es) 2005-09-01
US20050158387A1 (en) 2005-07-21
CA2447924A1 (en) 2003-01-09
EP1399127A1 (en) 2004-03-24
PT1399127E (pt) 2005-07-29
DE60204142D1 (de) 2005-06-16
DK1399127T3 (da) 2005-06-13
MXPA03011947A (es) 2004-03-26
JP5328947B2 (ja) 2013-10-30
JP2013127005A (ja) 2013-06-27
BRPI0210707B1 (pt) 2015-08-04
JP2010150292A (ja) 2010-07-08

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