CN1211125C - 局部给药的盐酸奥洛他定制剂 - Google Patents

局部给药的盐酸奥洛他定制剂 Download PDF

Info

Publication number
CN1211125C
CN1211125C CNB028120434A CN02812043A CN1211125C CN 1211125 C CN1211125 C CN 1211125C CN B028120434 A CNB028120434 A CN B028120434A CN 02812043 A CN02812043 A CN 02812043A CN 1211125 C CN1211125 C CN 1211125C
Authority
CN
China
Prior art keywords
polyvinylpyrrolidone
solution
olopatadine
composition
clear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB028120434A
Other languages
English (en)
Chinese (zh)
Other versions
CN1525849A (zh
Inventor
E·J·卡斯蒂略
韩维新
H·张
H·G·巴加特
O·N·辛格
J·P·布洛克
S·C·迪克西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Pharmaceuticals Ltd
Novartis AG
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23162841&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1211125(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of CN1525849A publication Critical patent/CN1525849A/zh
Application granted granted Critical
Publication of CN1211125C publication Critical patent/CN1211125C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028120434A 2001-06-27 2002-06-19 局部给药的盐酸奥洛他定制剂 Expired - Lifetime CN1211125C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30131501P 2001-06-27 2001-06-27
US60/301,315 2001-06-27

Publications (2)

Publication Number Publication Date
CN1525849A CN1525849A (zh) 2004-09-01
CN1211125C true CN1211125C (zh) 2005-07-20

Family

ID=23162841

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028120434A Expired - Lifetime CN1211125C (zh) 2001-06-27 2002-06-19 局部给药的盐酸奥洛他定制剂

Country Status (20)

Country Link
US (2) US6995186B2 (enExample)
EP (1) EP1399127B1 (enExample)
JP (5) JP4827374B2 (enExample)
KR (1) KR100884711B1 (enExample)
CN (1) CN1211125C (enExample)
AR (1) AR034619A1 (enExample)
AT (1) ATE295149T1 (enExample)
AU (1) AU2002310461B2 (enExample)
BR (1) BRPI0210707B8 (enExample)
CA (1) CA2447924C (enExample)
DE (1) DE60204142T2 (enExample)
DK (1) DK1399127T3 (enExample)
ES (1) ES2238574T3 (enExample)
GC (1) GC0000397A (enExample)
MX (1) MXPA03011947A (enExample)
PL (1) PL205565B1 (enExample)
PT (1) PT1399127E (enExample)
TW (1) TWI231759B (enExample)
WO (1) WO2003002093A1 (enExample)
ZA (1) ZA200308771B (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100055152A1 (en) * 2008-08-26 2010-03-04 Trutek Corporation Antihistamine and antihistamine-like nasal application, products, and method
US7977376B2 (en) * 2001-06-27 2011-07-12 Novartis Ag Olopatadine formulations for topical nasal administration
TWI231759B (en) * 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
US20050209312A1 (en) * 2004-03-19 2005-09-22 Bausch & Lomb Incorporated Carboxylic acid derivatives of doxepin formulations preserved with low-irritation preservative
JP5121229B2 (ja) * 2004-04-08 2013-01-16 協和発酵キリン株式会社 安定性の向上した固形製剤およびその製造方法
JPWO2005102313A1 (ja) * 2004-04-21 2007-08-16 協和醗酵工業株式会社 慢性副鼻腔炎の予防および／または治療剤
KR20070024618A (ko) * 2004-06-28 2007-03-02 알콘, 인코퍼레이티드 알레르기성 질환 치료용 국소 제제
CA2586553C (en) * 2004-11-24 2015-02-10 Alcon, Inc. Nasal sprayer containing a formulation with olopatadine
WO2006097458A1 (en) * 2005-03-15 2006-09-21 Nycomed Gmbh Novel combination
JP5315051B2 (ja) * 2005-07-08 2013-10-16 千寿製薬株式会社 オロパタジンを含む眼科用経皮吸収型製剤
US20070077302A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for stabilizing ophthalmic compositions
WO2008067127A2 (en) 2006-11-09 2008-06-05 Alcon Research, Ltd. Water insoluble polymer matrix for drug delivery
US20080114076A1 (en) * 2006-11-09 2008-05-15 Alcon Manufacturing Ltd. Punctal plug comprising a water-insoluble polymeric matrix
CA2670944A1 (en) * 2006-12-18 2008-06-26 Alcon Research, Ltd. Devices and methods for ophthalmic drug delivery
WO2008093358A2 (en) * 2007-01-29 2008-08-07 Sun Pharmaceutical Industries Limited Aqueous topical solution containing olopatadine
CA2677631C (en) * 2007-02-07 2014-05-13 Alcon, Inc. Olopatadine formulations for topical nasal administration
WO2008120249A1 (en) * 2007-03-30 2008-10-09 Sifi S.P.A. Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use
CN101641094A (zh) * 2007-04-11 2010-02-03 爱尔康研究有限公司 TNFα抑制剂联合抗组胺药治疗变应性鼻炎和变应性结膜炎的用途
CA2698651A1 (en) 2007-09-06 2009-03-12 Kyowa Hakko Kirin Co., Ltd. Eye drop containing dibenz [b,e] oxepin derivative
US20090286826A1 (en) * 2008-05-19 2009-11-19 Francisco Javier Galan Pharmaceutical compositions having carboxyvinyl polymer and povidone polymer
EP2318101A1 (en) * 2008-08-26 2011-05-11 Trutek Corp. Electrostatically charged mask filter products and method for increased filtration efficiency
JP2012509250A (ja) * 2008-08-28 2012-04-19 トルテック コーポレーション 抗ヒスタミン及び抗ヒスタミン様経鼻適用製品及び方法
US9458198B1 (en) 2009-06-26 2016-10-04 Shire Orphan Therapies Gmbh Cyclic peptide-based NPR-B agonists
CN102470099A (zh) * 2009-07-17 2012-05-23 爱尔康研究有限公司 儿童用奥洛他定鼻腔喷雾方案
WO2011027322A1 (en) 2009-09-03 2011-03-10 Ranbaxy Laboratories Limited Extended release dosage form containing olopatadine for oral administration
WO2011038066A2 (en) * 2009-09-25 2011-03-31 Alcon Research, Ltd. Novel npr-b agonists
BR112012006579A2 (pt) * 2009-09-25 2016-11-22 Alcon Res Ltd agonistas de npr-b.
BR112012007091A2 (pt) * 2009-10-01 2016-04-19 Alcon Res Ltd composições de olopatadina e seus usos
WO2011075471A2 (en) 2009-12-18 2011-06-23 Alcon Research, Ltd. Novel npr-b agonists and methods of use for the treatment of c-type natriuretic peptide-mediated disorders
AR078446A1 (es) 2009-12-18 2011-11-09 Alcon Res Ltd Agonistas de npr-b. uso.
MX2013000578A (es) * 2010-07-21 2013-02-21 Alcon Res Ltd Composicion farmaceutica con caracteristicas de solubilidad incrementadas.
US20120264681A1 (en) * 2010-11-08 2012-10-18 Healor Ltd. Buffered ophthalmic compositions and methods of use thereof
TWI544922B (zh) * 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
CN102885767A (zh) * 2012-11-02 2013-01-23 江苏吉贝尔药业有限公司 一种新的盐酸奥洛他定滴眼液及其制备方法
JP2020505476A (ja) 2017-02-01 2020-02-20 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 眼科障害の治療のための化合物および組成物
WO2018235935A1 (ja) * 2017-06-23 2018-12-27 参天製薬株式会社 水溶性粘稠化剤を含有する医薬組成物
JP7037349B2 (ja) * 2017-06-23 2022-03-16 参天製薬株式会社 水溶性粘稠化剤を含有する医薬組成物
CN114980881A (zh) * 2019-12-06 2022-08-30 东兴药品工业株式会社 包含奥洛他定的鼻用组合物
TWI896607B (zh) * 2020-03-31 2025-09-11 日商參天製藥股份有限公司 填充於樹脂製容器之含銀鹽眼科用水性組合物
CN111700860A (zh) * 2020-07-09 2020-09-25 浙江尖峰药业有限公司 盐酸奥洛他定滴眼液及其制备方法
CN119318630B (zh) * 2024-10-16 2025-08-22 苏州欧康维视生物科技有限公司 一种阿托品药物组合物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370324A (en) 1980-09-17 1983-01-25 Bernstein Joel E Method and composition for treating and preventing irritation of the eyes
US4407791A (en) * 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
US4749700A (en) 1984-10-23 1988-06-07 Nastech Pharmaceutical Co, Inc. Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same
US4923892A (en) 1985-08-17 1990-05-08 Burroughs Wellcome Co. Tricyclic aromatic compounds
GB8520662D0 (en) 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds
JPS6310784A (ja) 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
ES2053678T3 (es) 1987-11-13 1994-08-01 Asta Medica Ag Procedimiento para preparar un medicamento con contenido de azelastina para la aplicacion nasal y/u ocular.
IT1250691B (it) 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
JP3662944B2 (ja) 1993-08-24 2005-06-22 協和醗酵工業株式会社 点鼻剤
US5897858A (en) 1994-02-03 1999-04-27 Schering-Plough Healthcare Products, Inc. Nasal spray compositions exhibiting increased retention in the nasal cavity
US5641805A (en) 1995-06-06 1997-06-24 Alcon Laboratories, Inc. Topical ophthalmic formulations for treating allergic eye diseases
US6207684B1 (en) 1997-06-09 2001-03-27 Bridge Pharma, Inc. Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use
WO2000003705A1 (en) 1998-07-14 2000-01-27 Alcon Laboratories, Inc. Use of 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid for the manufacture of a medicament for treating non-allergic ophthalmic inflammatory disorders and for the prevention of ocular neovascularization
EP1124535B1 (en) * 1998-10-27 2002-12-11 Alcon Laboratories, Inc. Preservative system for topically administrable pharmaceutical compositions containing a fatty acid/amino acid soap
US6146622A (en) 1998-10-27 2000-11-14 Alcon Laboratories, Inc. Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions
US6274626B1 (en) * 1998-12-22 2001-08-14 Bausch & Lomb Incorporated Pheniramine-containing compositions and method for treating allergic responses
US6174914B1 (en) 1999-06-15 2001-01-16 Alcon Laboratories, Inc. Method of inhibiting cytokine release from human ocular cells
TR200200724T2 (tr) 1999-09-21 2002-06-21 Alcon Laboratories, Inc. Cilde sürülebilen farmasötik bileşimlerin antimikrobik etkisinin arttırılması için yağlı asit/amino asit sabunlarının kullanımı
AU772406B2 (en) 1999-11-18 2004-04-29 Alcon Inc. Use of H1 antagonist and a safe steroid to treat eye conditions
CA2395866C (en) * 2000-01-25 2009-10-13 Alcon, Inc. Ophthalmic anti-allergy compositions suitable for use with contact lenses
AR031135A1 (es) 2000-10-10 2003-09-10 Upjohn Co Composiciones de antibiotico topico para el tratamiento de infecciones oculares
TWI231759B (en) * 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
PL376970A1 (pl) 2002-11-12 2006-01-23 Alcon, Inc. Zastosowanie środka przeciwalergicznego i steroidu do leczenia alergicznego nieżytu nosa

Also Published As

Publication number Publication date
PT1399127E (pt) 2005-07-29
CA2447924A1 (en) 2003-01-09
ZA200308771B (en) 2005-01-26
PL205565B1 (pl) 2010-05-31
JP2013127005A (ja) 2013-06-27
GC0000397A (en) 2007-03-31
BRPI0210707B1 (pt) 2015-08-04
BR0210707A (pt) 2004-07-20
KR100884711B1 (ko) 2009-02-19
JP2009114213A (ja) 2009-05-28
ES2238574T3 (es) 2005-09-01
DE60204142T2 (de) 2005-10-06
EP1399127B1 (en) 2005-05-11
CN1525849A (zh) 2004-09-01
WO2003002093A1 (en) 2003-01-09
CA2447924C (en) 2009-11-03
MXPA03011947A (es) 2004-03-26
US7402609B2 (en) 2008-07-22
JP2004536096A (ja) 2004-12-02
AU2002310461B2 (en) 2006-05-18
US20030055102A1 (en) 2003-03-20
PL367780A1 (en) 2005-03-07
US20050158387A1 (en) 2005-07-21
DK1399127T3 (da) 2005-06-13
EP1399127A1 (en) 2004-03-24
ATE295149T1 (de) 2005-05-15
US6995186B2 (en) 2006-02-07
JP4827374B2 (ja) 2011-11-30
KR20040025919A (ko) 2004-03-26
BRPI0210707B8 (pt) 2021-05-25
HK1059573A1 (en) 2004-07-09
JP2012107046A (ja) 2012-06-07
JP2010150292A (ja) 2010-07-08
AR034619A1 (es) 2004-03-03
DE60204142D1 (de) 2005-06-16
JP5328947B2 (ja) 2013-10-30
TWI231759B (en) 2005-05-01

Similar Documents

Publication Publication Date Title
CN1211125C (zh) 局部给药的盐酸奥洛他定制剂
AU2002310461A1 (en) Olopatadine formulations for topical administation
CN100350976C (zh) 用于眼部药物递送的可逆胶凝系统
CN1376054A (zh) 含环丙沙星和地塞米松的局部悬浮制剂
CN1514735A (zh) 含有透明质酸的眼药组合物
CN1144476A (zh) 含离子敏感的亲水聚合物和无机盐的低粘度的眼药组合物
JP2012516187A (ja) 貯蔵安定性プロスタグランジン製品
US9801813B2 (en) Preservative-free ophthalmic pharmaceutical formulation
BRPI0709985A2 (pt) composição de brimonidina e timolol
WO2014120293A1 (en) Ophthalmic formulations
HK1007503B (en) Ophthalmic composition containing timolol hemihydrate
EP0577913A1 (en) Pharmaceutical preparation
WO2013175285A1 (en) Process for preparing ophthalmic suspension of brinzolamde
JP7721498B2 (ja) 樹脂製容器に充填された銀塩含有眼科用水性組成物
CN1087169C (zh) 抗炎症点眼剂
WO2010120841A1 (en) Aqueous ophthalmic compositions containing anionic therapeutic agents
HK1059573B (en) Olopatadine formulations for topical administration

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20170428

Address after: Basel, Switzerland

Patentee after: NOVARTIS AG

Address before: The Swiss ha Nan Bogdan

Patentee before: ALCON, Inc.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20200214

Address after: Basel, Switzerland

Patentee after: NOVARTIS AG

Address before: Fribourg

Patentee before: Alcon Pharmaceuticals Ltd.

Effective date of registration: 20200214

Address after: Fribourg

Patentee after: ALCON PHARMACEUTICALS LTD.

Address before: Basel, Switzerland

Patentee before: NOVARTIS AG

TR01 Transfer of patent right
CX01 Expiry of patent term

Granted publication date: 20050720

CX01 Expiry of patent term