TWI222441B - Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors - Google Patents

Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors Download PDF

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Publication number
TWI222441B
TWI222441B TW087119488A TW87119488A TWI222441B TW I222441 B TWI222441 B TW I222441B TW 087119488 A TW087119488 A TW 087119488A TW 87119488 A TW87119488 A TW 87119488A TW I222441 B TWI222441 B TW I222441B
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TW
Taiwan
Prior art keywords
methyl
amino
pyridone
aminocarbonylmethyl
ministry
Prior art date
Application number
TW087119488A
Other languages
English (en)
Chinese (zh)
Inventor
Tianbao Lu
Bruce E Tomczuk
Thomas P Markotan
Colleen Siedem
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
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Publication of TWI222441B publication Critical patent/TWI222441B/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
TW087119488A 1997-11-26 1998-11-25 Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors TWI222441B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6647597P 1997-11-26 1997-11-26
US6732497P 1997-12-05 1997-12-05
US7910798P 1998-03-23 1998-03-23

Publications (1)

Publication Number Publication Date
TWI222441B true TWI222441B (en) 2004-10-21

Family

ID=27370979

Family Applications (1)

Application Number Title Priority Date Filing Date
TW087119488A TWI222441B (en) 1997-11-26 1998-11-25 Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors

Country Status (14)

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US (8) US6037356A (US06566379-20030520-C00022.png)
EP (1) EP1036063B1 (US06566379-20030520-C00022.png)
JP (1) JP2001524467A (US06566379-20030520-C00022.png)
AR (1) AR016702A1 (US06566379-20030520-C00022.png)
AT (1) ATE344246T1 (US06566379-20030520-C00022.png)
AU (1) AU751412B2 (US06566379-20030520-C00022.png)
BR (1) BR9815325A (US06566379-20030520-C00022.png)
CA (1) CA2311969A1 (US06566379-20030520-C00022.png)
DE (1) DE69836346T2 (US06566379-20030520-C00022.png)
EA (1) EA004180B1 (US06566379-20030520-C00022.png)
ES (1) ES2274587T3 (US06566379-20030520-C00022.png)
PL (1) PL340560A1 (US06566379-20030520-C00022.png)
TW (1) TWI222441B (US06566379-20030520-C00022.png)
WO (1) WO1999026926A1 (US06566379-20030520-C00022.png)

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Also Published As

Publication number Publication date
US6350764B2 (en) 2002-02-26
EA004180B1 (ru) 2004-02-26
US20020086872A1 (en) 2002-07-04
EA200000578A1 (ru) 2001-02-26
AU751412B2 (en) 2002-08-15
US6245763B1 (en) 2001-06-12
JP2001524467A (ja) 2001-12-04
US20040106633A1 (en) 2004-06-03
EP1036063A1 (en) 2000-09-20
PL340560A1 (en) 2001-02-12
ATE344246T1 (de) 2006-11-15
DE69836346D1 (de) 2006-12-14
US20020007070A1 (en) 2002-01-17
US7402586B2 (en) 2008-07-22
US6566379B1 (en) 2003-05-20
AR016702A1 (es) 2001-07-25
EP1036063B1 (en) 2006-11-02
WO1999026926A1 (en) 1999-06-03
US20060211719A1 (en) 2006-09-21
US7029654B2 (en) 2006-04-18
CA2311969A1 (en) 1999-06-03
ES2274587T3 (es) 2007-05-16
US20030087921A1 (en) 2003-05-08
BR9815325A (pt) 2001-12-26
US6037356A (en) 2000-03-14
US6472399B2 (en) 2002-10-29
US20030225115A1 (en) 2003-12-04
AU1799199A (en) 1999-06-15
DE69836346T2 (de) 2007-05-24
US6706021B2 (en) 2004-03-16

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