TW209217B - - Google Patents
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- Publication number
- TW209217B TW209217B TW080106084A TW80106084A TW209217B TW 209217 B TW209217 B TW 209217B TW 080106084 A TW080106084 A TW 080106084A TW 80106084 A TW80106084 A TW 80106084A TW 209217 B TW209217 B TW 209217B
- Authority
- TW
- Taiwan
- Prior art keywords
- formula
- compound
- alkyl
- group
- ministry
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55432590A | 1990-07-19 | 1990-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW209217B true TW209217B (forum.php) | 1993-07-11 |
Family
ID=24212925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW080106084A TW209217B (forum.php) | 1990-07-19 | 1991-08-03 |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0539420B1 (forum.php) |
| JP (1) | JP3085707B2 (forum.php) |
| KR (1) | KR100206723B1 (forum.php) |
| CN (1) | CN1037770C (forum.php) |
| AT (1) | ATE188477T1 (forum.php) |
| AU (1) | AU646280B2 (forum.php) |
| CA (1) | CA2086546A1 (forum.php) |
| CZ (1) | CZ279903B6 (forum.php) |
| DE (1) | DE69131895T2 (forum.php) |
| DK (1) | DK0539420T3 (forum.php) |
| ES (1) | ES2142802T3 (forum.php) |
| FI (1) | FI102753B1 (forum.php) |
| GR (1) | GR3032999T3 (forum.php) |
| HU (1) | HU221298B1 (forum.php) |
| IE (1) | IE912533A1 (forum.php) |
| IL (1) | IL98865A (forum.php) |
| MX (1) | MX9100307A (forum.php) |
| NO (1) | NO304791B1 (forum.php) |
| NZ (1) | NZ238863A (forum.php) |
| PH (1) | PH31063A (forum.php) |
| PL (1) | PL170580B1 (forum.php) |
| PT (1) | PT98366B (forum.php) |
| RU (1) | RU2067978C1 (forum.php) |
| SK (1) | SK280690B6 (forum.php) |
| TW (1) | TW209217B (forum.php) |
| WO (1) | WO1992001697A1 (forum.php) |
| ZA (1) | ZA915654B (forum.php) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2048109B1 (es) * | 1992-07-20 | 1994-12-16 | Espanola Prod Quimicos | Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol. |
| US6211199B1 (en) | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
| US6194406B1 (en) | 1995-12-20 | 2001-02-27 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease |
| US6423704B2 (en) | 1995-12-20 | 2002-07-23 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases |
| US5922737A (en) * | 1996-02-21 | 1999-07-13 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases |
| US5932571A (en) * | 1996-02-21 | 1999-08-03 | Hoechst Marion Roussel, Inc. | Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases |
| US5998439A (en) | 1996-02-21 | 1999-12-07 | Hoescht Marion Roussel, Inc. | Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases |
| SK18942001A3 (sk) | 1999-06-28 | 2002-10-08 | Janssen Pharmaceutica N. V. | Inhibítory replikácie respiračného syncytiálneho vírusu |
| PT1196410E (pt) * | 1999-06-28 | 2004-07-30 | Janssen Pharmaceutica Nv | Inibidores da replicacao de virus sincicial respiratorio |
| CN1210275C (zh) * | 1999-06-28 | 2005-07-13 | 詹森药业有限公司 | 呼吸道合胞病毒复制抑制剂 |
| ES2213611T3 (es) * | 1999-10-08 | 2004-09-01 | Grunenthal Gmbh | Derivados biciclicos de imidazo-3-il-amina. |
| MXPA05007485A (es) | 2003-01-14 | 2006-01-30 | Arena Pharm Inc | Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia. |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| RU2239637C1 (ru) * | 2003-07-17 | 2004-11-10 | Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. | Улучшенный способ получения 5-[2-этокси-5-(4-метилпиперазин-1-илсульфонил)фенил]-1 метил-3-н-пропил-1,6-дигидро-7h-пиразол [4,3-d] пиримидин-7-она |
| RU2264814C2 (ru) * | 2003-12-29 | 2005-11-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Антигистаминная фармацевтическая композиция |
| EP1751113B1 (en) * | 2004-05-12 | 2010-03-10 | Brystol-Myers Squibb Company | Urea antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| DE102004044884A1 (de) * | 2004-09-14 | 2006-05-24 | Grünenthal GmbH | Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen |
| DOP2006000010A (es) | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
| JP5941916B2 (ja) | 2010-09-22 | 2016-06-29 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｇｐｒ１１９レセプターのモジュレーターおよびそれに関連する障害の処置 |
| EP3040334A1 (en) * | 2014-12-29 | 2016-07-06 | Faes Farma, S.A. | New benzimidazole derivatives as antihistamine agents |
| PT3242666T (pt) | 2015-01-06 | 2024-12-09 | Arena Pharm Inc | Composto para utilização no tratamento de patologias relacionadas com o recetor s1p1 |
| US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
| JP7397011B2 (ja) | 2018-06-06 | 2023-12-12 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4556660A (en) * | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
| US4634704A (en) * | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| US4695569A (en) * | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
| US4695575A (en) | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
| US4588722A (en) * | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
| GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
| US4835161A (en) * | 1986-02-03 | 1989-05-30 | Janssen Pharmaceutica N.V. | Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines |
| DE3701863A1 (de) * | 1987-01-23 | 1988-08-04 | Standard Elektrik Lorenz Ag | Sender zur kohaerent optischen nachrichtenuebertragung |
| US4897401A (en) * | 1987-06-19 | 1990-01-30 | Janssen Pharmaceutical N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases |
| CA1317939C (en) * | 1987-07-01 | 1993-05-18 | Janssen Pharmaceutica Naamloze Vennootschap | ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines |
| GB8900380D0 (en) * | 1989-01-09 | 1989-03-08 | Janssen Pharmaceutica Nv | 2-aminopyrimidinone derivatives |
-
1991
- 1991-07-05 NZ NZ238863A patent/NZ238863A/xx unknown
- 1991-07-09 CA CA002086546A patent/CA2086546A1/en not_active Abandoned
- 1991-07-09 EP EP91912667A patent/EP0539420B1/en not_active Expired - Lifetime
- 1991-07-09 HU HU9300096A patent/HU221298B1/hu not_active IP Right Cessation
- 1991-07-09 WO PCT/EP1991/001292 patent/WO1992001697A1/en active IP Right Grant
- 1991-07-09 DK DK91912667T patent/DK0539420T3/da active
- 1991-07-09 AT AT91912667T patent/ATE188477T1/de not_active IP Right Cessation
- 1991-07-09 AU AU82093/91A patent/AU646280B2/en not_active Ceased
- 1991-07-09 ES ES91912667T patent/ES2142802T3/es not_active Expired - Lifetime
- 1991-07-09 PL PL91297612A patent/PL170580B1/pl not_active IP Right Cessation
- 1991-07-09 DE DE69131895T patent/DE69131895T2/de not_active Expired - Fee Related
- 1991-07-09 RU RU9192016595A patent/RU2067978C1/ru not_active IP Right Cessation
- 1991-07-09 KR KR1019930700122A patent/KR100206723B1/ko not_active Expired - Fee Related
- 1991-07-09 JP JP03511645A patent/JP3085707B2/ja not_active Expired - Fee Related
- 1991-07-11 PH PH42771A patent/PH31063A/en unknown
- 1991-07-17 IL IL9886591A patent/IL98865A/en not_active IP Right Cessation
- 1991-07-18 ZA ZA915654A patent/ZA915654B/xx unknown
- 1991-07-18 SK SK2239-91A patent/SK280690B6/sk unknown
- 1991-07-18 IE IE253391A patent/IE912533A1/en not_active Application Discontinuation
- 1991-07-18 CZ CS912239A patent/CZ279903B6/cs not_active IP Right Cessation
- 1991-07-18 PT PT98366A patent/PT98366B/pt not_active IP Right Cessation
- 1991-07-19 MX MX9100307A patent/MX9100307A/es not_active IP Right Cessation
- 1991-07-19 CN CN91104906A patent/CN1037770C/zh not_active Expired - Fee Related
- 1991-08-03 TW TW080106084A patent/TW209217B/zh active
-
1993
- 1993-01-15 NO NO924313A patent/NO304791B1/no unknown
- 1993-01-18 FI FI930199A patent/FI102753B1/fi active
-
2000
- 2000-03-21 GR GR20000400699T patent/GR3032999T3/el not_active IP Right Cessation
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