US2940972A
(en)
|
1957-06-27 |
1960-06-14 |
Thomae Gmbh Dr K |
Tri-and tetra-substituted pteridine derivatives
|
GB1583753A
(en)
|
1976-07-14 |
1981-02-04 |
Science Union & Cie |
Piperidine derivatives processes for their preparation and pharmaceutical compositions containing them
|
US4666828A
(en)
|
1984-08-15 |
1987-05-19 |
The General Hospital Corporation |
Test for Huntington's disease
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
US4801531A
(en)
|
1985-04-17 |
1989-01-31 |
Biotechnology Research Partners, Ltd. |
Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
|
US5272057A
(en)
|
1988-10-14 |
1993-12-21 |
Georgetown University |
Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
|
US5192659A
(en)
|
1989-08-25 |
1993-03-09 |
Genetype Ag |
Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
|
GB9125001D0
(en)
|
1991-11-25 |
1992-01-22 |
Ici Plc |
Heterocyclic compounds
|
TW219935B
(zh)
|
1991-12-25 |
1994-02-01 |
Mitsubishi Chemicals Co Ltd |
|
WO1994026723A2
(en)
|
1993-05-14 |
1994-11-24 |
Genentech, Inc. |
ras FARNESYL TRANSFERASE INHIBITORS
|
US5700823A
(en)
|
1994-01-07 |
1997-12-23 |
Sugen, Inc. |
Treatment of platelet derived growth factor related disorders such as cancers
|
US6331555B1
(en)
|
1995-06-01 |
2001-12-18 |
University Of California |
Treatment of platelet derived growth factor related disorders such as cancers
|
US5882864A
(en)
|
1995-07-31 |
1999-03-16 |
Urocor Inc. |
Biomarkers and targets for diagnosis, prognosis and management of prostate disease
|
US6218529B1
(en)
|
1995-07-31 |
2001-04-17 |
Urocor, Inc. |
Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
|
TW472045B
(en)
|
1996-09-25 |
2002-01-11 |
Astra Ab |
Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
|
IL133009A0
(en)
|
1997-05-28 |
2001-03-19 |
Aventis Pharm Prod Inc |
Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases
|
US6235740B1
(en)
|
1997-08-25 |
2001-05-22 |
Bristol-Myers Squibb Co. |
Imidazoquinoxaline protein tyrosine kinase inhibitors
|
UA71555C2
(en)
|
1997-10-06 |
2004-12-15 |
Zentaris Gmbh |
Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
|
EP1147094A1
(en)
|
1999-01-15 |
2001-10-24 |
Novo Nordisk A/S |
Non-peptide glp-1 agonists
|
IL145357A0
(en)
|
1999-03-17 |
2002-06-30 |
Astrazeneca Ab |
Amide derivatives
|
SK3542002A3
(en)
|
1999-09-15 |
2003-04-01 |
Warner Lambert Co |
Pteridinones as kinase inhibitors
|
DE10013318A1
(de)
|
2000-03-17 |
2001-09-20 |
Merck Patent Gmbh |
Formulierung enthaltend Chinoxalinderivate
|
WO2002076985A1
(en)
|
2001-03-23 |
2002-10-03 |
Smithkline Beecham Corporation |
Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
|
US20030114448A1
(en)
|
2001-05-31 |
2003-06-19 |
Millennium Pharmaceuticals, Inc. |
Inhibitors of factor Xa
|
JP4286146B2
(ja)
|
2001-12-18 |
2009-06-24 |
メルク エンド カムパニー インコーポレーテッド |
メタボトロピックグルタミン酸受容体−5のヘテロアリール置換ピラゾール系調節剤
|
ATE446093T1
(de)
|
2001-12-24 |
2009-11-15 |
Astrazeneca Ab |
Substituierte chinazolin-derivate als aurora- kinase inhibitoren
|
JP2003213463A
(ja)
|
2002-01-17 |
2003-07-30 |
Sumitomo Chem Co Ltd |
金属腐食防止剤および洗浄液
|
WO2003076416A1
(en)
|
2002-03-08 |
2003-09-18 |
Warner-Lambert Company Llc |
Oxo azabicyclic compounds
|
AU2003223467B2
(en)
|
2002-04-08 |
2007-10-04 |
Merck Sharp & Dohme Corp. |
Inhibitors of Akt activity
|
US7074534B2
(en)
|
2002-07-10 |
2006-07-11 |
E. I. Du Pont De Nemours And Company |
Polymeric charge transport compositions and electronic devices made with such compositions
|
US7825132B2
(en)
|
2002-08-23 |
2010-11-02 |
Novartis Vaccines And Diagnostics, Inc. |
Inhibition of FGFR3 and treatment of multiple myeloma
|
AU2003282726B2
(en)
|
2002-10-03 |
2010-10-07 |
Targegen, Inc. |
Vasculostatic agents and methods of use thereof
|
AR043059A1
(es)
|
2002-11-12 |
2005-07-13 |
Bayer Pharmaceuticals Corp |
Derivados de indolil pirazinona utiles para el tratamiento de trastornos hiper-proliferativos
|
US7098332B2
(en)
|
2002-12-20 |
2006-08-29 |
Hoffmann-La Roche Inc. |
5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
|
BRPI0406809A
(pt)
|
2003-01-17 |
2005-12-27 |
Warner Lambert Co |
Heterociclos substituìdos de 2-aminopiridina como inibidores da proliferação celular
|
WO2004098494A2
(en)
|
2003-04-30 |
2004-11-18 |
Cytokinetics, Inc. |
Compounds, compositions, and methods
|
KR20060023529A
(ko)
|
2003-05-14 |
2006-03-14 |
토레이파인스 테라퓨틱스, 인코포레이티드 |
화합물 및 아밀로이드 베타를 변조하는데 있어서 그의 용도
|
DE10323345A1
(de)
|
2003-05-23 |
2004-12-16 |
Zentaris Gmbh |
Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren
|
EP1636228B1
(de)
|
2003-05-23 |
2008-10-22 |
AEterna Zentaris GmbH |
Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
|
WO2005007099A2
(en)
|
2003-07-10 |
2005-01-27 |
Imclone Systems Incorporated |
Pkb inhibitors as anti-tumor agents
|
US7339065B2
(en)
|
2003-07-21 |
2008-03-04 |
Bethesda Pharmaceuticals, Inc. |
Design and synthesis of optimized ligands for PPAR
|
KR20060054410A
(ko)
|
2003-08-01 |
2006-05-22 |
제네랩스 테크놀로지스, 인코포레이티드 |
플라비비리다에에 대한 2고리 이미다졸 유도체
|
PL1673092T3
(pl)
|
2003-10-17 |
2008-01-31 |
4 Aza Ip Nv |
Pochodne pterydyny podstawione heterocyklem i ich zastosowanie w leczeniu
|
CA2543820C
(en)
|
2003-11-07 |
2012-07-10 |
Chiron Corporation |
Methods for synthesizing quinolinone compounds
|
KR101118582B1
(ko)
|
2003-11-20 |
2012-02-27 |
얀센 파마슈티카 엔.브이. |
폴리(adp-리보스)폴리머라제 저해제로서의 6-알케닐 및6-페닐알킬 치환된 2-퀴놀리논 및 2-퀴녹살리논
|
MXPA06005735A
(es)
|
2003-11-24 |
2006-08-17 |
Hoffmann La Roche |
Pirazolil e imidazolil pirimidinas.
|
PL1706385T3
(pl)
|
2003-12-23 |
2011-03-31 |
Astex Therapeutics Ltd |
Pochodne pirazolu jako modulatory kinazy białkowej
|
US7098222B2
(en)
|
2004-05-12 |
2006-08-29 |
Abbott Laboratories |
Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
|
US7205316B2
(en)
|
2004-05-12 |
2007-04-17 |
Abbott Laboratories |
Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
|
KR20070048798A
(ko)
|
2004-08-31 |
2007-05-09 |
아스트라제네카 아베 |
퀴나졸리논 유도체 및 이것의 b-raf 억제제로서의 용도
|
JP2008516905A
(ja)
|
2004-10-14 |
2008-05-22 |
エフ.ホフマン−ラ ロシュ アーゲー |
Cdk1抗増殖活性を有する1,5−ナフチリジンアゾリジノン
|
US20080207616A1
(en)
|
2004-10-15 |
2008-08-28 |
Astrazeneca Ab |
Quinoxalines as B Baf Inhhibitors
|
NZ555334A
(en)
|
2004-12-24 |
2010-05-28 |
Spinifex Pharm Pty Ltd |
Method of treatment or prophylaxis of a neuropathic condition using AT2 receptor antagonist
|
CA2597447C
(en)
|
2005-02-14 |
2014-03-25 |
Bionomics Limited |
Novel tubulin polymerisation inhibitors
|
EP1853261B1
(de)
|
2005-03-03 |
2017-01-11 |
Universität des Saarlandes |
Selektive hemmstoffe humaner corticoidsynthasen
|
US20090156617A1
(en)
|
2005-05-12 |
2009-06-18 |
Northrup Alan B |
Tyrosine kinase inhibitors
|
JP2008540667A
(ja)
|
2005-05-18 |
2008-11-20 |
ワイス |
Tpl2キナーゼの4,6−ジアミノ−[1,7]ナフチリジン−3−カルボニトリル阻害物質ならびにそれを製造および使用する方法
|
GB0513692D0
(en)
|
2005-07-04 |
2005-08-10 |
Karobio Ab |
Novel pharmaceutical compositions
|
JP5226513B2
(ja)
|
2005-08-26 |
2013-07-03 |
メルク セローノ ソシエテ アノニム |
ピラジン誘導体及びその使用
|
EP1790342A1
(de)
|
2005-11-11 |
2007-05-30 |
Zentaris GmbH |
Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
|
WO2007054556A1
(de)
|
2005-11-11 |
2007-05-18 |
Æterna Zentaris Gmbh |
Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
|
US8217042B2
(en)
|
2005-11-11 |
2012-07-10 |
Zentaris Gmbh |
Pyridopyrazines and their use as modulators of kinases
|
DK1966214T3
(en)
|
2005-12-21 |
2017-02-13 |
Janssen Pharmaceutica Nv |
TRIAZOLPYRIDAZINES AS TYROSINKINASA MODULATORS
|
WO2007125405A2
(en)
|
2006-05-01 |
2007-11-08 |
Pfizer Products Inc. |
Substituted 2-amino-fused heterocyclic compounds
|
GB0609621D0
(en)
|
2006-05-16 |
2006-06-21 |
Astrazeneca Ab |
Novel co-crystal
|
EP2029600B1
(de)
|
2006-05-24 |
2012-03-14 |
Boehringer Ingelheim International GmbH |
Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind
|
JO3235B1
(ar)
|
2006-05-26 |
2018-03-08 |
Astex Therapeutics Ltd |
مركبات بيررولوبيريميدين و استعمالاتها
|
EP2044027A2
(en)
|
2006-07-03 |
2009-04-08 |
Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg |
Fused bicyclic compounds interacting with the histamine h4 receptor
|
JP2008127446A
(ja)
|
2006-11-20 |
2008-06-05 |
Canon Inc |
1,5−ナフチリジン化合物及び有機発光素子
|
AU2007334456A1
(en)
|
2006-12-13 |
2008-06-26 |
Merck Sharp & Dohme Corp. |
Methods of cancer treatment with IGF1R inhibitors
|
EP2094701A2
(en)
|
2006-12-21 |
2009-09-02 |
Plexxikon, Inc. |
Compounds and methods for kinase modulation, and indications therefor
|
JP5442448B2
(ja)
|
2006-12-22 |
2014-03-12 |
アステックス、セラピューティックス、リミテッド |
Fgfrインヒビターとしての二環式ヘテロ環式化合物
|
MX2009006627A
(es)
|
2006-12-22 |
2009-08-12 |
Novartis Ag |
Quinazolinas para la inhibicion de pdk1.
|
KR20080062876A
(ko)
|
2006-12-29 |
2008-07-03 |
주식회사 대웅제약 |
신규한 항진균성 트리아졸 유도체
|
EP1990342A1
(en)
|
2007-05-10 |
2008-11-12 |
AEterna Zentaris GmbH |
Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
|
TW200902008A
(en)
|
2007-05-10 |
2009-01-16 |
Smithkline Beecham Corp |
Quinoxaline derivatives as PI3 kinase inhibitors
|
US20100179143A1
(en)
|
2007-05-29 |
2010-07-15 |
Smithkline Beecham Corporation |
Naphthyridine, derivatives as p13 kinase inhibitors
|
AR066879A1
(es)
|
2007-06-08 |
2009-09-16 |
Novartis Ag |
Derivados de quinoxalina como inhibidores de la actividad de cinasa de tirosina de las cinasas janus
|
BRPI0813105A2
(pt)
|
2007-06-20 |
2015-08-04 |
Mitsubishi Tanabe Pharma Corp |
Derivado de sulfonamida de ácido malônico e uso faramacêutico do mesmo
|
EP2170894A1
(en)
|
2007-06-21 |
2010-04-07 |
Janssen Pharmaceutica N.V. |
Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline
|
EP2173338A1
(en)
|
2007-07-06 |
2010-04-14 |
OSI Pharmaceuticals, Inc. |
Combination anti-cancer therapy
|
EP2188292B1
(en)
|
2007-08-08 |
2013-05-29 |
GlaxoSmithKline Intellectual Property Development Limited |
2- [ (2-{phenylamino}-1h-pyrrolo [2, 3-d]pyrimidin-4-yl) amino]benzamide derivatives as igf-1r inhibitors for the treatment of cancer
|
EP2173354A4
(en)
|
2007-08-09 |
2011-10-05 |
Glaxosmithkline Llc |
CHINOXALIN DERIVATIVES AS PI3 KINASE INHIBITORS
|
WO2009019518A1
(en)
|
2007-08-09 |
2009-02-12 |
Astrazeneca Ab |
Pyrimidine compounds having a fgfr inhibitory effect
|
US20090054304A1
(en)
|
2007-08-23 |
2009-02-26 |
Kalypsys, Inc. |
Heterocyclic modulators of tgr5 for treatment of disease
|
CN101910152B
(zh)
|
2007-11-16 |
2014-08-06 |
因塞特公司 |
作为janus激酶抑制剂的4-吡唑基-n-芳基嘧啶-2-胺和4-吡唑基-n-杂芳基嘧啶-2-胺
|
MX2010012064A
(es)
|
2008-05-05 |
2010-12-06 |
Schering Corp |
Uso secuencial de agentes quimioterapeuticos citotoxicos para el tratamiento de cancer.
|
JP5351254B2
(ja)
|
2008-05-23 |
2013-11-27 |
ノバルティス アーゲー |
キノキサリン−およびキノリン−カルボキシアミド誘導体
|
JP2012509342A
(ja)
|
2008-11-20 |
2012-04-19 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
置換ピロロ[2,3−b]−ピリジンおよび−ピラジン
|
CA2750047A1
(en)
|
2009-01-21 |
2010-07-29 |
Basilea Pharmaceutica Ag |
Novel bicyclic antibiotics
|
CA2750051A1
(en)
|
2009-02-02 |
2010-08-05 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
TW201041888A
(en)
|
2009-05-06 |
2010-12-01 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
FI2440546T3
(fi)
|
2009-06-12 |
2023-03-30 |
Abivax |
Ennenaikaisen vanhenemisen ja erityisesti progerian hoitamiseen hyödyllisiä yhdisteitä
|
CA2772714C
(en)
|
2009-09-03 |
2017-09-26 |
Bioenergenix |
Heterocyclic compounds for the inhibition of pask
|
JP5728683B2
(ja)
|
2009-09-04 |
2015-06-03 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH |
チロシンスレオニンキナーゼ阻害剤としての置換アミノキノキサリン
|
US9095596B2
(en)
|
2009-10-15 |
2015-08-04 |
Southern Research Institute |
Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for such
|
US20110123545A1
(en)
|
2009-11-24 |
2011-05-26 |
Bristol-Myers Squibb Company |
Combination of vegfr2 and igf1r inhibitors for the treatment of proliferative diseases
|
EP2332939A1
(en)
|
2009-11-26 |
2011-06-15 |
Æterna Zentaris GmbH |
Novel Naphthyridine derivatives and the use thereof as kinase inhibitors
|
NZ700332A
(en)
|
2010-03-30 |
2017-06-30 |
Verseon Corp |
Multisubstituted aromatic compounds as inhibitors of thrombin
|
GB201007286D0
(en)
*
|
2010-04-30 |
2010-06-16 |
Astex Therapeutics Ltd |
New compounds
|
WO2011146591A1
(en)
|
2010-05-19 |
2011-11-24 |
Millennium Pharmaceuticals, Inc. |
Substituted hydroxamic acids and uses thereof
|
EP2575462B1
(en)
|
2010-05-24 |
2016-06-22 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
GB201020179D0
(en)
|
2010-11-29 |
2011-01-12 |
Astex Therapeutics Ltd |
New compounds
|
CN102532141A
(zh)
|
2010-12-08 |
2012-07-04 |
中国科学院上海药物研究所 |
[1,2,4]三唑并[4,3-b][1,2,4]三嗪类化合物、其制备方法和用途
|
PL2670753T3
(pl)
|
2011-01-31 |
2017-05-31 |
Novartis Ag |
Nowe pochodne heterocykliczne
|
CA2825894C
(en)
|
2011-02-02 |
2021-11-30 |
Amgen Inc. |
Prognosis of cancer using a circulating biomarker
|
JP6130305B2
(ja)
|
2011-02-23 |
2017-05-17 |
インテリカイン, エルエルシー |
キナーゼ阻害剤の組み合わせおよびそれらの使用
|
WO2012118492A1
(en)
|
2011-03-01 |
2012-09-07 |
Array Biopharma Inc. |
Heterocyclic sulfonamides as raf inhibitors
|
US9896730B2
(en)
|
2011-04-25 |
2018-02-20 |
OSI Pharmaceuticals, LLC |
Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
|
JP5934787B2
(ja)
|
2011-05-10 |
2016-06-15 |
ギリアード サイエンシーズ, インコーポレイテッド |
イオンチャネルモジュレーターとしての縮合複素環式化合物
|
CA2846574C
(en)
|
2011-08-26 |
2020-07-07 |
Neupharma, Inc. |
Quinoxaline sulfonamide derivates for use as kinase inhibitors
|
CA2848506C
(en)
|
2011-09-14 |
2020-07-21 |
Neupharma, Inc. |
Certain chemical entities, compositions, and methods
|
WO2013043935A1
(en)
|
2011-09-21 |
2013-03-28 |
Neupharma, Inc. |
Certain chemical entites, compositions, and methods
|
WO2013052699A2
(en)
|
2011-10-04 |
2013-04-11 |
Gilead Calistoga Llc |
Novel quinoxaline inhibitors of pi3k
|
GB201118654D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
GB201118675D0
(en)
|
2011-10-28 |
2011-12-14 |
Astex Therapeutics Ltd |
New compounds
|
GB201118652D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
GB201118656D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
MX340452B
(es)
|
2011-10-28 |
2016-07-08 |
Novartis Ag |
Novedosos derivados de purina y su uso en el tratamiento de enfermedades.
|
JO3210B1
(ar)
|
2011-10-28 |
2018-03-08 |
Merck Sharp & Dohme |
مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
|
EA029140B1
(ru)
|
2012-03-08 |
2018-02-28 |
Астеллас Фарма Инк. |
Новый слитый fgfr3
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
GB201209609D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
US20150203589A1
(en)
|
2012-07-24 |
2015-07-23 |
The Trustees Of Columbia University In The City Of New York |
Fusion proteins and methods thereof
|
EP3939614A1
(en)
|
2013-01-18 |
2022-01-19 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
GB201307577D0
(en)
|
2013-04-26 |
2013-06-12 |
Astex Therapeutics Ltd |
New compounds
|
JP2016527274A
(ja)
|
2013-08-02 |
2016-09-08 |
イグナイタ インコーポレイテッド |
AXL/cMET阻害剤を単独または他の薬剤と組み合わせて用いて各種がんを治療する方法
|
US9221804B2
(en)
|
2013-10-15 |
2015-12-29 |
Janssen Pharmaceutica Nv |
Secondary alcohol quinolinyl modulators of RORγt
|
AU2015238301B2
(en)
|
2014-03-26 |
2020-06-25 |
Astex Therapeutics Ltd |
Combinations
|
JO3512B1
(ar)
|
2014-03-26 |
2020-07-05 |
Astex Therapeutics Ltd |
مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
|
KR102479696B1
(ko)
|
2014-03-26 |
2022-12-22 |
아스텍스 테라퓨틱스 리미티드 |
Fgfr 억제제 및 igf1r 억제제의 조합물
|
JOP20200201A1
(ar)
|
2015-02-10 |
2017-06-16 |
Astex Therapeutics Ltd |
تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
|
JP6774421B2
(ja)
|
2015-02-19 |
2020-10-21 |
フュージョン ファーマシューティカルズ インク. |
がんの治療のための方法、組成物、及びキット
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|