TW201612316A - Porcine pseudorabies virus gene deletion strain, vaccine composition, and preparation method and application of vaccine composition - Google Patents

Porcine pseudorabies virus gene deletion strain, vaccine composition, and preparation method and application of vaccine composition

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Publication number
TW201612316A
TW201612316A TW104127275A TW104127275A TW201612316A TW 201612316 A TW201612316 A TW 201612316A TW 104127275 A TW104127275 A TW 104127275A TW 104127275 A TW104127275 A TW 104127275A TW 201612316 A TW201612316 A TW 201612316A
Authority
TW
Taiwan
Prior art keywords
vaccine composition
porcine pseudorabies
pseudorabies virus
preparation
application
Prior art date
Application number
TW104127275A
Other languages
English (en)
Inventor
ke-gong Tian
xu-ke Zhang
jin-zhong Sun
fei-fei Tan
Original Assignee
Pulike Biolog Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pulike Biolog Engineering Inc filed Critical Pulike Biolog Engineering Inc
Publication of TW201612316A publication Critical patent/TW201612316A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16721—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16762—Methods of inactivation or attenuation by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16771—Demonstrated in vivo effect
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect
TW104127275A 2014-08-22 2015-08-21 Porcine pseudorabies virus gene deletion strain, vaccine composition, and preparation method and application of vaccine composition TW201612316A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410418379.8A CN104250640A (zh) 2014-08-22 2014-08-22 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用

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TW201612316A true TW201612316A (en) 2016-04-01

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US (3) US10548972B2 (zh)
EP (1) EP3012322B1 (zh)
JP (1) JP6368725B2 (zh)
CN (2) CN104250640A (zh)
DK (1) DK3012322T3 (zh)
TW (1) TW201612316A (zh)
WO (1) WO2016026264A1 (zh)

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CN104250640A (zh) * 2014-08-22 2014-12-31 普莱柯生物工程股份有限公司 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用
CN111560355A (zh) * 2015-03-20 2020-08-21 普莱柯生物工程股份有限公司 一种猪伪狂犬病病毒致弱方法、及其致弱的病毒株、疫苗组合物和应用
CN106282132A (zh) * 2015-05-11 2017-01-04 中国农业科学院上海兽医研究所 伪狂犬病毒变异株的弱毒株及其应用
CN106310248B (zh) * 2015-06-18 2019-12-20 普莱柯生物工程股份有限公司 猪伪狂犬病病毒活疫苗组合物用于治疗猪伪狂犬病的用途
CN108251382B (zh) * 2016-12-29 2021-08-20 普莱柯生物工程股份有限公司 一种猪伪狂犬病病毒致弱方法、及其致弱的病毒株、疫苗组合物和应用
CN107828741B (zh) * 2017-11-07 2021-01-12 江苏省农业科学院 伪狂犬病病毒双基因缺失弱毒株及其应用
CN108553641A (zh) * 2018-05-15 2018-09-21 贵州都匀市黔昌畜牧发展有限责任公司 一种伪狂犬病免疫方法
CN109609468B (zh) * 2018-12-10 2020-06-30 畜科生物工程有限公司 一种六基因缺失的猪伪狂犬病毒、猪伪狂犬病疫苗以及制备方法
CN109337874B (zh) * 2018-12-10 2020-05-12 畜科生物工程有限公司 一种重组猪伪狂犬病毒及其应用和重组猪伪狂犬病活疫苗
CN109750005A (zh) * 2018-12-26 2019-05-14 河南农业大学 一种猪伪狂犬病重组病毒株及其构建方法
CN109750007A (zh) * 2019-02-01 2019-05-14 华南农业大学 双表达gC基因的伪狂犬病毒gE/gI缺失突变株及其构建和应用
CN110241090B (zh) * 2019-05-07 2023-10-13 江苏南农高科技股份有限公司 一种全悬浮细胞培养生产猪伪狂犬病毒抗原的方法
CN110257345B (zh) * 2019-07-18 2021-07-16 河南农业大学 一种猪伪狂犬病双基因缺失变异突变病毒毒株及其构建方法
CN110527669B (zh) * 2019-09-06 2021-07-06 中牧实业股份有限公司 一种猪伪狂犬病病毒基因缺失毒株及其构建方法和应用
CN112831477A (zh) * 2019-11-25 2021-05-25 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 表达猪瘟病毒E2蛋白和猪圆环病毒Cap蛋白的重组伪狂犬病病毒株及其构建方法和用途
CN111154733A (zh) * 2020-01-09 2020-05-15 天津瑞普生物技术股份有限公司 一种伪狂犬病毒弱毒株及应用
CN111748529B (zh) * 2020-06-19 2022-01-11 国药集团动物保健股份有限公司 猪伪狂犬病病毒毒株及其应用
CN112342201B (zh) * 2020-11-04 2023-01-03 武汉科前生物股份有限公司 一种通过CRISPR/Cas9制备的猪伪狂犬病弱毒株及其应用
CN112501133B (zh) * 2020-12-01 2022-05-24 山东信得科技股份有限公司 一种伪狂犬病毒qd株三基因缺失致弱株
CN115216451A (zh) * 2021-04-16 2022-10-21 硕腾服务有限责任公司 伪狂犬病病毒疫苗
CN113444697A (zh) * 2021-04-19 2021-09-28 温氏食品集团股份有限公司 重组猪伪狂犬病毒及其制备方法和应用
CN113957171A (zh) * 2021-10-26 2022-01-21 苏州药明检测检验有限责任公司 一种组织半数感染法染色测定伪狂犬病毒滴度的方法
CN116064557A (zh) * 2022-09-15 2023-05-05 华中农业大学 激活猪的ogfod2基因表达的制剂在制备猪抗伪狂犬病毒感染药物中的应用
CN116790509B (zh) * 2023-06-28 2024-02-02 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种分泌抗猪伪狂犬病病毒gB蛋白抗体的单克隆杂交瘤细胞株及其应用
CN117384863B (zh) * 2023-10-18 2024-04-05 武汉科前生物股份有限公司 猪伪狂犬病病毒自然传代弱毒变异株js18-150及其应用
CN117106736B (zh) * 2023-10-25 2024-02-20 江西农业大学 利用cbe构建三基因缺失prv毒株的方法和应用
CN117126818B (zh) * 2023-10-25 2024-02-02 江西农业大学 利用ABE构建gE基因缺失PRV毒株的方法和应用

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US10201605B2 (en) 2019-02-12
US20160317650A1 (en) 2016-11-03
CN104250640A (zh) 2014-12-31
US10548972B2 (en) 2020-02-04
US20160279232A1 (en) 2016-09-29
US20160281065A1 (en) 2016-09-29
WO2016026264A1 (zh) 2016-02-25
DK3012322T3 (da) 2019-10-07
EP3012322A1 (en) 2016-04-27
CN104862286A (zh) 2015-08-26
CN104862286B (zh) 2018-09-11
EP3012322B1 (en) 2019-08-28
JP6368725B2 (ja) 2018-08-01
EP3012322A4 (en) 2016-07-20
JP2016531545A (ja) 2016-10-13

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