DK3012322T3 - Gendeleteret stamme af porcint pseudorabiesvirus, vaccinesammensætning og fremgangsmåde til fremstilling deraf og anvendelse deraf - Google Patents

Gendeleteret stamme af porcint pseudorabiesvirus, vaccinesammensætning og fremgangsmåde til fremstilling deraf og anvendelse deraf Download PDF

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DK3012322T3
DK3012322T3 DK15808317.0T DK15808317T DK3012322T3 DK 3012322 T3 DK3012322 T3 DK 3012322T3 DK 15808317 T DK15808317 T DK 15808317T DK 3012322 T3 DK3012322 T3 DK 3012322T3
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porcint
treasures
released
preparing
procedure
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DK15808317.0T
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Kegong Tian
Xuke Zhang
Jinzhong Sun
Feifei Tan
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Pulike Biological Eng Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
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    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation
    • C12N2710/16762—Methods of inactivation or attenuation by genetic engineering
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16771—Demonstrated in vivo effect
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    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20071—Demonstrated in vivo effect

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DK15808317.0T 2014-08-22 2015-01-06 Gendeleteret stamme af porcint pseudorabiesvirus, vaccinesammensætning og fremgangsmåde til fremstilling deraf og anvendelse deraf DK3012322T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410418379.8A CN104250640A (zh) 2014-08-22 2014-08-22 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用
PCT/CN2015/070221 WO2016026264A1 (zh) 2014-08-22 2015-01-06 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用

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US (3) US10548972B2 (da)
EP (1) EP3012322B1 (da)
JP (1) JP6368725B2 (da)
CN (2) CN104250640A (da)
DK (1) DK3012322T3 (da)
TW (1) TW201612316A (da)
WO (1) WO2016026264A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104250640A (zh) 2014-08-22 2014-12-31 普莱柯生物工程股份有限公司 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用
CN111560355A (zh) * 2015-03-20 2020-08-21 普莱柯生物工程股份有限公司 一种猪伪狂犬病病毒致弱方法、及其致弱的病毒株、疫苗组合物和应用
CN106282132A (zh) * 2015-05-11 2017-01-04 中国农业科学院上海兽医研究所 伪狂犬病毒变异株的弱毒株及其应用
CN106310248B (zh) * 2015-06-18 2019-12-20 普莱柯生物工程股份有限公司 猪伪狂犬病病毒活疫苗组合物用于治疗猪伪狂犬病的用途
CN108251382B (zh) * 2016-12-29 2021-08-20 普莱柯生物工程股份有限公司 一种猪伪狂犬病病毒致弱方法、及其致弱的病毒株、疫苗组合物和应用
CN107828741B (zh) * 2017-11-07 2021-01-12 江苏省农业科学院 伪狂犬病病毒双基因缺失弱毒株及其应用
CN108553641A (zh) * 2018-05-15 2018-09-21 贵州都匀市黔昌畜牧发展有限责任公司 一种伪狂犬病免疫方法
CN109337874B (zh) * 2018-12-10 2020-05-12 畜科生物工程有限公司 一种重组猪伪狂犬病毒及其应用和重组猪伪狂犬病活疫苗
CN109609468B (zh) * 2018-12-10 2020-06-30 畜科生物工程有限公司 一种六基因缺失的猪伪狂犬病毒、猪伪狂犬病疫苗以及制备方法
CN109750005A (zh) * 2018-12-26 2019-05-14 河南农业大学 一种猪伪狂犬病重组病毒株及其构建方法
CN109750007A (zh) * 2019-02-01 2019-05-14 华南农业大学 双表达gC基因的伪狂犬病毒gE/gI缺失突变株及其构建和应用
CN110241090B (zh) * 2019-05-07 2023-10-13 江苏南农高科技股份有限公司 一种全悬浮细胞培养生产猪伪狂犬病毒抗原的方法
CN110257345B (zh) * 2019-07-18 2021-07-16 河南农业大学 一种猪伪狂犬病双基因缺失变异突变病毒毒株及其构建方法
CN110527669B (zh) * 2019-09-06 2021-07-06 中牧实业股份有限公司 一种猪伪狂犬病病毒基因缺失毒株及其构建方法和应用
CN112831477A (zh) * 2019-11-25 2021-05-25 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 表达猪瘟病毒E2蛋白和猪圆环病毒Cap蛋白的重组伪狂犬病病毒株及其构建方法和用途
CN111154733A (zh) * 2020-01-09 2020-05-15 天津瑞普生物技术股份有限公司 一种伪狂犬病毒弱毒株及应用
CN111748529B (zh) * 2020-06-19 2022-01-11 国药集团动物保健股份有限公司 猪伪狂犬病病毒毒株及其应用
CN112342201B (zh) * 2020-11-04 2023-01-03 武汉科前生物股份有限公司 一种通过CRISPR/Cas9制备的猪伪狂犬病弱毒株及其应用
CN112501133B (zh) * 2020-12-01 2022-05-24 山东信得科技股份有限公司 一种伪狂犬病毒qd株三基因缺失致弱株
CN115216451A (zh) * 2021-04-16 2022-10-21 硕腾服务有限责任公司 伪狂犬病病毒疫苗
CN113444697A (zh) * 2021-04-19 2021-09-28 温氏食品集团股份有限公司 重组猪伪狂犬病毒及其制备方法和应用
CN113957171A (zh) * 2021-10-26 2022-01-21 苏州药明检测检验有限责任公司 一种组织半数感染法染色测定伪狂犬病毒滴度的方法
CN116064557A (zh) * 2022-09-15 2023-05-05 华中农业大学 激活猪的ogfod2基因表达的制剂在制备猪抗伪狂犬病毒感染药物中的应用
CN116790509B (zh) * 2023-06-28 2024-02-02 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） 一种分泌抗猪伪狂犬病病毒gB蛋白抗体的单克隆杂交瘤细胞株及其应用
CN117384863B (zh) * 2023-10-18 2024-04-05 武汉科前生物股份有限公司 猪伪狂犬病病毒自然传代弱毒变异株js18-150及其应用
CN117126818B (zh) * 2023-10-25 2024-02-02 江西农业大学 利用ABE构建gE基因缺失PRV毒株的方法和应用
CN117106736B (zh) * 2023-10-25 2024-02-20 江西农业大学 利用cbe构建三基因缺失prv毒株的方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
US4514497B1 (en) * 1983-12-30 1998-02-24 Novagene Inc Modified live pseudorabies viruses
TW289731B (da) * 1992-07-09 1996-11-01 Akzo Nv
FR2781159B1 (fr) 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
CN100354414C (zh) * 2005-09-29 2007-12-12 华中农业大学 一种伪狂犬病gEˉ/gIˉ基因缺失毒株、含有该毒株的灭活疫苗及应用
EP2018182A4 (en) 2006-05-19 2010-10-06 Inst Medical W & E Hall IMMUNOGENIC COMPOSITIONS
CN101186902B (zh) * 2006-07-04 2010-11-10 四川农业大学 伪狂犬病病毒sa215和伪狂犬病毒多基因缺失疫苗及其制备方法
KR20100094587A (ko) 2007-12-21 2010-08-26 와이어쓰 엘엘씨 돼지 써코바이러스에 대해 돼지를 면역시키는 방법 및 조성물
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
CA2837125A1 (en) * 2011-05-27 2012-12-06 Sinovet (Beijing) Biotechnology Co.,Ltd Combined vaccines for prevention of porcine virus infections
CN102994458B (zh) 2012-11-26 2014-04-02 中国农业科学院哈尔滨兽医研究所 猪伪狂犬病病毒强毒株、其基因缺失疫苗株及其应用
CN103756977B (zh) 2013-12-11 2016-01-06 姜平 猪伪狂犬病变异株gE和gI基因缺失病毒株及其应用
CN103627678B (zh) 2013-12-19 2016-03-02 姜平 一种猪伪狂犬病病毒变异株prv-zj01及应用
CN103923884B (zh) 2014-02-21 2017-03-29 普莱柯生物工程股份有限公司 一种猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用
CN103981153B (zh) 2014-05-29 2017-07-07 中国兽医药品监察所 伪狂犬病病毒双荧光标记缺失病毒的构建
CN104250640A (zh) * 2014-08-22 2014-12-31 普莱柯生物工程股份有限公司 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用

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US10548972B2 (en) 2020-02-04
US20160317650A1 (en) 2016-11-03
CN104862286B (zh) 2018-09-11
US20160279232A1 (en) 2016-09-29
TW201612316A (en) 2016-04-01
JP2016531545A (ja) 2016-10-13
US20160281065A1 (en) 2016-09-29
EP3012322B1 (en) 2019-08-28
US10201605B2 (en) 2019-02-12
EP3012322A1 (en) 2016-04-27
WO2016026264A1 (zh) 2016-02-25
CN104250640A (zh) 2014-12-31
CN104862286A (zh) 2015-08-26
EP3012322A4 (en) 2016-07-20
JP6368725B2 (ja) 2018-08-01

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