TW201105674A - Novel JAK receptor and protein tyrosine kinase inhibitors and pharmaceutical use thereof - Google Patents
Novel JAK receptor and protein tyrosine kinase inhibitors and pharmaceutical use thereof Download PDFInfo
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- TW201105674A TW201105674A TW099122542A TW99122542A TW201105674A TW 201105674 A TW201105674 A TW 201105674A TW 099122542 A TW099122542 A TW 099122542A TW 99122542 A TW99122542 A TW 99122542A TW 201105674 A TW201105674 A TW 201105674A
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- diaza
- pyrrolo
- pyrimidin
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| PT1966202E (pt) | 2005-12-13 | 2012-01-03 | Incyte Corp | Pirrolo[2,3-b] pirimidinas e pirrolo[2,3-b]piridinas substituídas com heteroarilo como inibidores de janus quinase |
| TW201100429A (en) | 2009-05-22 | 2011-01-01 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| PL2432472T3 (pl) | 2009-05-22 | 2020-03-31 | Incyte Holdings Corporation | 3-[4-(7H-Pirolo[2,3-d]pirymidyn-4-ylo)-1H-pirazol-1-ilo]oktano- lub heptano-nitryle jako inhibitory JAK |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| WO2011029054A1 (en) | 2009-09-04 | 2011-03-10 | The Regents Of The University Of Michigan | Compositions and methods for treatment of leukemia |
| WO2011029043A1 (en) | 2009-09-04 | 2011-03-10 | Biogen Idec Ma Inc. | Heteroaryl btk inhibitors |
| MX354212B (es) | 2010-03-10 | 2018-02-19 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
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| US8993756B2 (en) * | 2011-12-06 | 2015-03-31 | Merck Sharp & Dohme Corp. | Pyrrolopyrimidines as janus kinase inhibitors |
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| CN104662015B (zh) * | 2012-06-20 | 2017-03-29 | 诺华股份有限公司 | 补体途径调节剂及其用途 |
| WO2014039714A2 (en) * | 2012-09-06 | 2014-03-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP2015529242A (ja) | 2012-09-21 | 2015-10-05 | アドヴィヌス セラピューティクス リミテッドＡｄｖｉｎｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | 置換された縮合三環式化合物、組成物およびその医薬用途 |
| BR112015009942A2 (pt) * | 2012-11-01 | 2017-07-11 | Incyte Corp | derivados de tiofeno fundidos tricíclicos como inibidores de jak |
| NZ708157A (en) | 2012-11-15 | 2019-07-26 | Incyte Holdings Corp | Sustained-release dosage forms of ruxolitinib |
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| WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
| BR112015023878A2 (pt) | 2013-03-19 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
| CN105189508B (zh) * | 2013-03-19 | 2018-11-23 | 默沙东公司 | 作为janus激酶抑制剂的环烷基腈吡唑并吡啶酮 |
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| US9233953B2 (en) * | 2013-10-16 | 2016-01-12 | Boehringer Ingelheim International Gmbh | Derivatives of 4-(piperazinylcarbonyl)thiane-1, 1-dione which inhibit GlyT1 |
| NZ720092A (en) * | 2013-12-05 | 2019-05-31 | Pfizer | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
| SG11201609016VA (en) | 2014-04-30 | 2016-11-29 | Incyte Corp | Processes of preparing a jak1 inhibitor and new forms thereto |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| NO2721710T3 (enExample) | 2014-08-21 | 2018-03-31 | ||
| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
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| CN114539284A (zh) | 2016-03-16 | 2022-05-27 | 库拉肿瘤学公司 | 经取代的menin-mll抑制剂及使用方法 |
| BR112018068702A2 (pt) | 2016-03-16 | 2019-01-15 | Kura Oncology Inc | inibidores bicíclicos em ponte de menin-mll e métodos de uso |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| RU2764980C2 (ru) * | 2017-01-20 | 2022-01-24 | Лео Фарма А/С | Бициклические амины в качестве новых ингибиторов jak-киназы |
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| CN108456212A (zh) * | 2018-05-30 | 2018-08-28 | 杨文思 | 一种化合物或其溶剂合物，或前体，或它们的药学上可接受的盐、药物及其用途 |
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| JP7629200B2 (ja) | 2018-11-20 | 2025-02-13 | ジョージタウン ユニバーシティ | 神経変性、筋変性及びリソソーム蓄積障害を治療するための組成物及び方法 |
| KR102112336B1 (ko) * | 2019-08-12 | 2020-05-18 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 헤테로고리 화합물 |
| MX2022002646A (es) | 2019-09-05 | 2022-04-26 | Incyte Corp | Formulacion de ruxolitinib para la reduccion de comezon en dermatitis atopica. |
| CA3167999A1 (en) * | 2020-03-17 | 2021-09-23 | Xin Li | Fused bicyclic derivative, preparation method therefor, and pharmaceutical use thereof |
| CN113698403B (zh) * | 2020-05-21 | 2022-06-28 | 南京亘泰医药技术有限公司 | (1r,4r,7r)-7-氨基-2-氮杂双环[2,2,1]庚烷衍生物及制备方法 |
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| CN114681461A (zh) * | 2020-12-28 | 2022-07-01 | 杭州邦顺制药有限公司 | 用于红斑狼疮治疗的化合物 |
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| CA3212256A1 (en) * | 2021-03-16 | 2022-09-22 | Juhyun Lee | Novel salts of heterocyclic compound as protein kinase inhibitor and uses thereof |
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| EP1087970B1 (en) | 1998-06-19 | 2004-04-28 | Pfizer Products Inc. | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS |
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| CN1195755C (zh) | 1999-12-10 | 2005-04-06 | 辉瑞产品公司 | 吡咯并[2,3－d]嘧啶化合物 |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| JP4768265B2 (ja) | 2002-10-15 | 2011-09-07 | シンタ ファーマシューティカルズ コーポレーション | 新規化合物 |
| SE0301372D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
| NZ547327A (en) | 2003-11-21 | 2009-08-28 | Array Biopharma Inc | AKT protein kinase inhibitors |
| MXPA06005882A (es) | 2003-11-25 | 2006-06-27 | Pfizer Prod Inc | Metodo de tratamiento de la aterosclerosis. |
| CN1893952A (zh) | 2003-12-17 | 2007-01-10 | 辉瑞产品公司 | 用于治疗移植排斥的吡咯并[2,3－d]嘧啶化合物 |
| TWI380816B (zh) | 2004-04-13 | 2013-01-01 | Synta Pharmaceuticals Corp | 抑制介白素-１２（ｉｌ-１２）生成之二鹽抑制劑 |
| AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| JP4652826B2 (ja) | 2005-01-14 | 2011-03-16 | タッチパネル・システムズ株式会社 | 情報入力装置 |
| KR20070104641A (ko) | 2005-02-03 | 2007-10-26 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제의 억제제로 유용한 피롤로피리미딘 |
| WO2006091450A1 (en) | 2005-02-18 | 2006-08-31 | Lexicon Genetics Incorporated | 4-piperidin-1-yl-7h-pyrrolo[2,3-d]pyrimidine compounds |
| NZ564065A (en) | 2005-05-20 | 2011-03-31 | Vertex Pharma | Pyrrolopyridines useful as inhibitors of protein kinase |
| CN102127078A (zh) | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
| ATE531718T1 (de) | 2006-03-11 | 2011-11-15 | Vernalis R&D Ltd | Als hsp90-inhibitoren verwendete pyrrolopyrimidinderivate |
| CA2648250A1 (en) | 2006-04-05 | 2007-10-18 | Vertex Pharmaceuticals Incorporated | Deazapurines useful as inhibitors of janus kinases |
| WO2008005368A2 (en) * | 2006-06-30 | 2008-01-10 | Abbott Laboratories | Piperazines as p2x7 antagonists |
| WO2008128072A2 (en) | 2007-04-13 | 2008-10-23 | Supergen, Inc. | Axl kinase inhibitors useful for the treatment of cancer or hyperproliferative disorders |
| WO2009021169A2 (en) | 2007-08-08 | 2009-02-12 | Lexicon Pharmaceuticals, Inc. | (7h-pyrr0l0 [2, 3-d] pyrimidin-4-yl) -piperazines as kinase inhibitors for the treatment of cancer and inflammation |
| WO2009089352A1 (en) * | 2008-01-08 | 2009-07-16 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
-
2010
- 2010-07-08 CA CA2767079A patent/CA2767079A1/en not_active Abandoned
- 2010-07-08 CN CN201080039685.0A patent/CN102574857B/zh not_active Expired - Fee Related
- 2010-07-08 EP EP10732839.5A patent/EP2451813B1/en active Active
- 2010-07-08 BR BR112012000422A patent/BR112012000422A2/pt not_active IP Right Cessation
- 2010-07-08 TW TW099122542A patent/TW201105674A/zh unknown
- 2010-07-08 JP JP2012518753A patent/JP5690823B2/ja not_active Expired - Fee Related
- 2010-07-08 US US13/382,665 patent/US9346809B2/en not_active Expired - Fee Related
- 2010-07-08 WO PCT/DK2010/000105 patent/WO2011003418A1/en not_active Ceased
- 2010-07-08 AR ARP100102482A patent/AR077465A1/es not_active Application Discontinuation
Also Published As
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|---|---|
| US9346809B2 (en) | 2016-05-24 |
| BR112012000422A2 (pt) | 2017-05-09 |
| EP2451813B1 (en) | 2014-10-01 |
| CA2767079A1 (en) | 2011-01-13 |
| EP2451813A1 (en) | 2012-05-16 |
| JP2012532152A (ja) | 2012-12-13 |
| CN102574857B (zh) | 2015-06-10 |
| CN102574857A (zh) | 2012-07-11 |
| WO2011003418A1 (en) | 2011-01-13 |
| AR077465A1 (es) | 2011-08-31 |
| US20120178740A1 (en) | 2012-07-12 |
| JP5690823B2 (ja) | 2015-03-25 |
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