TW200600506A - Substituted morpholine compounds for the treatment of central nervous system disorders - Google Patents
Substituted morpholine compounds for the treatment of central nervous system disordersInfo
- Publication number
- TW200600506A TW200600506A TW094113971A TW94113971A TW200600506A TW 200600506 A TW200600506 A TW 200600506A TW 094113971 A TW094113971 A TW 094113971A TW 94113971 A TW94113971 A TW 94113971A TW 200600506 A TW200600506 A TW 200600506A
- Authority
- TW
- Taiwan
- Prior art keywords
- treatment
- nervous system
- central nervous
- system disorders
- substituted morpholine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56724404P | 2004-04-30 | 2004-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200600506A true TW200600506A (en) | 2006-01-01 |
Family
ID=34965714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094113971A TW200600506A (en) | 2004-04-30 | 2005-04-29 | Substituted morpholine compounds for the treatment of central nervous system disorders |
Country Status (28)
Country | Link |
---|---|
US (1) | US7659394B2 (zh) |
EP (1) | EP1745029A1 (zh) |
JP (2) | JP4185154B2 (zh) |
KR (1) | KR100943555B1 (zh) |
CN (1) | CN1950348A (zh) |
AP (1) | AP2006003771A0 (zh) |
AR (1) | AR049335A1 (zh) |
AU (1) | AU2005238296A1 (zh) |
BR (1) | BRPI0510453A (zh) |
CA (1) | CA2564994A1 (zh) |
CR (1) | CR8718A (zh) |
EA (1) | EA200601798A1 (zh) |
EC (1) | ECSP066962A (zh) |
GE (1) | GEP20084550B (zh) |
GT (1) | GT200500097A (zh) |
IL (1) | IL178648A0 (zh) |
MA (1) | MA28555B1 (zh) |
MX (1) | MXPA06012505A (zh) |
NL (1) | NL1028924C2 (zh) |
NO (1) | NO20065456L (zh) |
PA (1) | PA8631301A1 (zh) |
PE (1) | PE20060680A1 (zh) |
SV (1) | SV2006002098A (zh) |
TN (1) | TNSN06348A1 (zh) |
TW (1) | TW200600506A (zh) |
UY (1) | UY28876A1 (zh) |
WO (1) | WO2005105763A1 (zh) |
ZA (1) | ZA200608628B (zh) |
Families Citing this family (32)
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CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物 |
US7704527B2 (en) * | 2002-10-25 | 2010-04-27 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
GEP20084550B (en) * | 2004-04-30 | 2008-11-25 | Warner Lambert Co | Substituted morpholine compounds for the treatment of central nervous system disorders |
GB0409744D0 (en) * | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
CA2641304A1 (en) * | 2006-02-01 | 2007-08-09 | Merck & Co., Inc. | Potassium channel inhibitors |
EP1854785A1 (en) * | 2006-05-12 | 2007-11-14 | Faes Farma, S.A. | 4-[(3-fluorophenoxy)phenylmethyl]piperidine methanesulfonate: uses, process of synthesis and pharmaceutical compositions |
US7531519B2 (en) * | 2006-09-21 | 2009-05-12 | Medical And Pharmaceutical Industry Technology And Development Center | Polygalatenosides and use thereof as an antidepressant agent |
TW200846003A (en) * | 2007-03-15 | 2008-12-01 | Astellas Pharma Inc | Novel prophylactic and/or therapeutic agent for diabetic neuropathy |
TW200846002A (en) * | 2007-03-15 | 2008-12-01 | Astellas Pharma Inc | Novel prophylactic and/or therapeutic agent for diabetic neuropathy |
EP2161998B1 (en) * | 2007-06-04 | 2015-09-02 | Intra-Cellular Therapies, Inc. | Pyridine derivatives as NET/SERT modulators |
JP5405571B2 (ja) * | 2008-07-24 | 2014-02-05 | セラヴァンス, インコーポレーテッド | 3−(フェノキシフェニルメチル)ピロリジン化合物 |
DK2358675T3 (da) | 2008-11-14 | 2013-01-14 | Theravance Inc | 4-[2-(2-Fluorphenoxymethyl)phenyl]piperidinforbindelser |
DK2385938T3 (en) | 2009-01-12 | 2015-04-27 | Pfizer Ltd | Sulfonamidderivater |
AR075988A1 (es) * | 2009-04-09 | 2011-05-11 | Lilly Co Eli | Compuesto de piridiloxi - pirrolidina inhibidor de recaptacion de serotonina y norepinefrina, composicion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de dolor cronico |
US8474529B2 (en) * | 2009-04-09 | 2013-07-02 | Regency Technologies Llc | Control of concentric tubing direction |
JP2012524098A (ja) * | 2009-04-15 | 2012-10-11 | セラヴァンス, インコーポレーテッド | 3−(フェノキシピロリジン−3−イル−メチル)ヘテロアリール、3−(フェニルピロリジン−3−イルメトキシ)ヘテロアリールおよび3−(ヘテロアリールピロリジン−3−イルメトキシ)ヘテロアリール化合物 |
MX2012000685A (es) * | 2009-07-13 | 2012-02-28 | Theravance Inc | Compuesto de 3-fenoximetilpirrolidina. |
WO2011011231A1 (en) | 2009-07-21 | 2011-01-27 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
UY32858A (es) | 2009-08-31 | 2011-03-31 | Abbott Healthcare Products Bv | Derivados de (tio)morfolina como moduladores de sip |
EP2523945A1 (en) * | 2010-01-11 | 2012-11-21 | Theravance, Inc. | 1 - (2 - phenoxymethylphenyl) piperazine compounds as serotonin and norepinephrine reuptake inhibitors |
JP5769348B2 (ja) * | 2010-03-22 | 2015-08-26 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | 1−(2−フェノキシメチルヘテロアリール)ピペリジン化合物および1−(2−フェノキシメチルヘテロアリール)ピペラジン化合物 |
JP2013526597A (ja) | 2010-05-24 | 2013-06-24 | ファエス・ファルマ・ソシエダッド・アノニマ | アミロイド病変の治療および予防のためのフルフェノキシン誘導体 |
EP2390248A1 (en) | 2010-05-24 | 2011-11-30 | Faes Farma, S.A. | Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies |
TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
WO2012051103A1 (en) | 2010-10-11 | 2012-04-19 | Theravance, Inc. | Serotonin reuptake inhibitors |
US8501964B2 (en) | 2010-12-03 | 2013-08-06 | Theravance, Inc. | Serotonin reuptake inhibitors |
JP2012207995A (ja) * | 2011-03-29 | 2012-10-25 | Univ Of Fukui | 脳内ノルエピネフリン・トランスポータを標的とする放射性臭素標識pet分子イメージングプローブ |
EP2745876A1 (en) * | 2012-12-21 | 2014-06-25 | Prous Institute for Biomedical Research, S.A. | Hydroxy aliphatic substituted phenyl aminoalkyl ether derivatives |
MY195528A (en) | 2016-03-17 | 2023-01-30 | Hoffmann La Roche | 5-Ethyl-4-Methyl-Pyrazole-3-Carboxamide Derivative Having Activity as Agonist of Taar |
BR112022008113A2 (pt) | 2019-10-31 | 2022-07-19 | Escape Bio Inc | Formas sólidas de um modulador de receptor s1p |
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BE758766A (fr) * | 1969-11-17 | 1971-05-10 | Ici Ltd | Nouveaux derives de la morpholine et de la |
BE759013R (fr) * | 1969-11-17 | 1971-05-17 | Ici Ltd | Derives de la |
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CA1215067A (en) | 1982-10-18 | 1986-12-09 | Sudarshan K. Malhotra | 2-(6-phenoxy-3-nitro-2-pyridinoxy)-propionate compounds |
GB8419683D0 (en) * | 1984-08-02 | 1984-09-05 | Erba Farmitalia | 3-substituted derivatives of 1-amino-2-hydroxy-propane |
GB2167407B (en) | 1984-11-22 | 1988-05-11 | Erba Farmitalia | Enantiomers of phenoxy derivatives of benzyl morpholine and salts thereof |
US4855143A (en) * | 1986-04-04 | 1989-08-08 | Hans Lowey | Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics |
US5272167A (en) * | 1986-12-10 | 1993-12-21 | Schering Corporation | Pharmaceutically active compounds |
US4851423A (en) | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
US5750532A (en) * | 1986-12-10 | 1998-05-12 | Schering Corporation | Pharmaceutically active compounds |
FR2612926B1 (fr) * | 1987-03-24 | 1989-06-09 | Adir | Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
FR2653999A1 (fr) | 1989-11-06 | 1991-05-10 | Adir | Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
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-
2005
- 2005-04-19 GE GEAP20059682A patent/GEP20084550B/en unknown
- 2005-04-19 CA CA002564994A patent/CA2564994A1/en not_active Abandoned
- 2005-04-19 KR KR1020067022767A patent/KR100943555B1/ko not_active IP Right Cessation
- 2005-04-19 CN CNA2005800137766A patent/CN1950348A/zh active Pending
- 2005-04-19 JP JP2007510153A patent/JP4185154B2/ja not_active Expired - Fee Related
- 2005-04-19 WO PCT/IB2005/001158 patent/WO2005105763A1/en active Application Filing
- 2005-04-19 BR BRPI0510453-0A patent/BRPI0510453A/pt not_active IP Right Cessation
- 2005-04-19 MX MXPA06012505A patent/MXPA06012505A/es unknown
- 2005-04-19 AP AP2006003771A patent/AP2006003771A0/xx unknown
- 2005-04-19 EA EA200601798A patent/EA200601798A1/ru unknown
- 2005-04-19 AU AU2005238296A patent/AU2005238296A1/en not_active Abandoned
- 2005-04-19 EP EP05733459A patent/EP1745029A1/en not_active Withdrawn
- 2005-04-27 PA PA20058631301A patent/PA8631301A1/es unknown
- 2005-04-28 PE PE2005000480A patent/PE20060680A1/es not_active Application Discontinuation
- 2005-04-28 AR ARP050101667A patent/AR049335A1/es unknown
- 2005-04-28 GT GT200500097A patent/GT200500097A/es unknown
- 2005-04-28 UY UY28876A patent/UY28876A1/es not_active Application Discontinuation
- 2005-04-29 TW TW094113971A patent/TW200600506A/zh unknown
- 2005-04-29 US US11/119,210 patent/US7659394B2/en not_active Expired - Fee Related
- 2005-04-29 NL NL1028924A patent/NL1028924C2/nl not_active IP Right Cessation
- 2005-04-29 SV SV2005002098A patent/SV2006002098A/es not_active Application Discontinuation
-
2006
- 2006-10-16 IL IL178648A patent/IL178648A0/en unknown
- 2006-10-16 ZA ZA200608628A patent/ZA200608628B/xx unknown
- 2006-10-27 CR CR8718A patent/CR8718A/es not_active Application Discontinuation
- 2006-10-27 TN TNP2006000348A patent/TNSN06348A1/fr unknown
- 2006-10-30 EC EC2006006962A patent/ECSP066962A/es unknown
- 2006-10-30 MA MA29418A patent/MA28555B1/fr unknown
- 2006-11-27 NO NO20065456A patent/NO20065456L/no not_active Application Discontinuation
-
2007
- 2007-09-07 JP JP2007233201A patent/JP2008019267A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ZA200608628B (en) | 2009-01-28 |
JP2007535530A (ja) | 2007-12-06 |
NL1028924A1 (nl) | 2005-11-01 |
WO2005105763A1 (en) | 2005-11-10 |
AU2005238296A1 (en) | 2005-11-10 |
CA2564994A1 (en) | 2005-11-10 |
KR20070006881A (ko) | 2007-01-11 |
MXPA06012505A (es) | 2006-12-15 |
CR8718A (es) | 2007-07-24 |
US20050245519A1 (en) | 2005-11-03 |
EP1745029A1 (en) | 2007-01-24 |
AR049335A1 (es) | 2006-07-19 |
MA28555B1 (fr) | 2007-04-03 |
PE20060680A1 (es) | 2006-08-11 |
AP2006003771A0 (en) | 2006-10-31 |
BRPI0510453A (pt) | 2007-10-30 |
JP4185154B2 (ja) | 2008-11-26 |
IL178648A0 (en) | 2007-02-11 |
NO20065456L (no) | 2007-01-04 |
UY28876A1 (es) | 2005-11-30 |
US7659394B2 (en) | 2010-02-09 |
SV2006002098A (es) | 2006-02-15 |
CN1950348A (zh) | 2007-04-18 |
KR100943555B1 (ko) | 2010-02-22 |
NL1028924C2 (nl) | 2006-04-27 |
ECSP066962A (es) | 2006-12-20 |
GT200500097A (es) | 2005-12-12 |
GEP20084550B (en) | 2008-11-25 |
TNSN06348A1 (fr) | 2008-02-22 |
EA200601798A1 (ru) | 2007-04-27 |
JP2008019267A (ja) | 2008-01-31 |
PA8631301A1 (es) | 2006-05-16 |
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