TR201910424T4 - DNA sekanslarını kodlayan poli(A) sekansının stabilizasyonu. - Google Patents
DNA sekanslarını kodlayan poli(A) sekansının stabilizasyonu. Download PDFInfo
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- TR201910424T4 TR201910424T4 TR2019/10424T TR201910424T TR201910424T4 TR 201910424 T4 TR201910424 T4 TR 201910424T4 TR 2019/10424 T TR2019/10424 T TR 2019/10424T TR 201910424 T TR201910424 T TR 201910424T TR 201910424 T4 TR201910424 T4 TR 201910424T4
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- poly
- stabilization
- nucleic acid
- sequence encoding
- dna sequences
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- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 108091034057 RNA (poly(A)) Proteins 0.000 title 1
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- C12N15/67—General methods for enhancing the expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
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- C12P21/00—Preparation of peptides or proteins
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Mevcut buluş, E.coli'de stabilize edilmiş poli(dA:dT) bölgelerini içeren nükleik asit molekülleri, E.coli'de bu tür nükleik asit moleküllerini yayılmasının yöntemleri, bu tür nükleik asit molekülleri kullanılarak RNA, peptidler veya proteinlerin elde edilmesi yöntemleri ile ve bu tür nükleik asit moleküllerinden elde edilen RNA ve bunun kullanımı ile ilgilidir. Özellikle, poli(dA:dT) bölgeleri, yalnızca A tortularından oluşan bir diziyi kodlamayan bir sekans tarafından en azından bir bozulma içerir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2014/064924 WO2016005004A1 (en) | 2014-07-11 | 2014-07-11 | Stabilization of poly(a) sequence encoding dna sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201910424T4 true TR201910424T4 (tr) | 2019-08-21 |
Family
ID=51220548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10424T TR201910424T4 (tr) | 2014-07-11 | 2015-07-06 | DNA sekanslarını kodlayan poli(A) sekansının stabilizasyonu. |
Country Status (14)
Country | Link |
---|---|
US (2) | US10717982B2 (tr) |
EP (2) | EP3167059B1 (tr) |
JP (2) | JP6759196B2 (tr) |
AU (2) | AU2015286820B2 (tr) |
CA (1) | CA2954706C (tr) |
DE (2) | DE202015010019U1 (tr) |
DK (1) | DK3167059T3 (tr) |
ES (1) | ES2735728T3 (tr) |
HU (1) | HUE046120T2 (tr) |
PL (1) | PL3167059T3 (tr) |
PT (1) | PT3167059T (tr) |
SI (1) | SI3167059T1 (tr) |
TR (1) | TR201910424T4 (tr) |
WO (2) | WO2016005004A1 (tr) |
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EP3167059A1 (en) | 2017-05-17 |
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SI3167059T1 (sl) | 2019-10-30 |
AU2021277776A1 (en) | 2021-12-23 |
PL3167059T3 (pl) | 2019-12-31 |
JP6759196B2 (ja) | 2020-09-23 |
EP3167059B1 (en) | 2019-06-26 |
EP3594337A1 (en) | 2020-01-15 |
AU2015286820A1 (en) | 2017-02-23 |
AU2015286820A8 (en) | 2017-03-30 |
WO2016005004A1 (en) | 2016-01-14 |
HUE046120T2 (hu) | 2020-02-28 |
DK3167059T3 (da) | 2019-08-05 |
CA2954706A1 (en) | 2016-01-14 |
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