MX2023003934A - Antigenos de consenso de filovirus, construcciones de acido nucleico y vacunas realizadas a partir de estos, y metodos para utilizarlos. - Google Patents
Antigenos de consenso de filovirus, construcciones de acido nucleico y vacunas realizadas a partir de estos, y metodos para utilizarlos.Info
- Publication number
- MX2023003934A MX2023003934A MX2023003934A MX2023003934A MX2023003934A MX 2023003934 A MX2023003934 A MX 2023003934A MX 2023003934 A MX2023003934 A MX 2023003934A MX 2023003934 A MX2023003934 A MX 2023003934A MX 2023003934 A MX2023003934 A MX 2023003934A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- nucleic acid
- ebolavirus
- disclosed
- vacciens
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 241000711950 Filoviridae Species 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 241001115402 Ebolavirus Species 0.000 abstract 5
- 108091026890 Coding region Proteins 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/14011—Filoviridae
- C12N2760/14111—Ebolavirus, e.g. Zaire ebolavirus
- C12N2760/14134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen moléculas de ácido nucleico y composiciones que comprenden una o más secuencias de ácido nucleico que codifican inmunógenos de glicoproteína de virus del Ébola de consenso; las secuencias codificantes incluyen opcionalmente una secuencia codificante unida operativa que codifica un péptido señal; se describen métodos inmunomoduladores y métodos para inducir una respuesta inmunitaria contra el virus del Ébola; se describe un método para prevenir el virus del Ébola y métodos para tratar individuos infectados con el virus del Ébola; se describen proteínas de virus del Ébola de consenso.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662332372P | 2016-05-05 | 2016-05-05 | |
| US201662402519P | 2016-09-30 | 2016-09-30 | |
| US201762483979P | 2017-04-11 | 2017-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023003934A true MX2023003934A (es) | 2023-04-26 |
Family
ID=60203604
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018013524A MX2018013524A (es) | 2016-05-05 | 2017-05-05 | Antígenos de consenso de filovirus, construcciones de ácido nucleico y vacunas realizadas a partir de estos, y métodos para utilizarlos. |
| MX2023003934A MX2023003934A (es) | 2016-05-05 | 2018-11-05 | Antigenos de consenso de filovirus, construcciones de acido nucleico y vacunas realizadas a partir de estos, y metodos para utilizarlos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018013524A MX2018013524A (es) | 2016-05-05 | 2017-05-05 | Antígenos de consenso de filovirus, construcciones de ácido nucleico y vacunas realizadas a partir de estos, y métodos para utilizarlos. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11091518B2 (es) |
| EP (1) | EP3452068A4 (es) |
| JP (2) | JP7029756B2 (es) |
| KR (2) | KR20240099514A (es) |
| CN (2) | CN110072536B (es) |
| AU (2) | AU2017261306B2 (es) |
| BR (1) | BR112018072719A2 (es) |
| CA (1) | CA3023098A1 (es) |
| MX (2) | MX2018013524A (es) |
| SG (2) | SG10202011017RA (es) |
| WO (1) | WO2017192947A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017192947A1 (en) * | 2016-05-05 | 2017-11-09 | Weiner, David | Filovirus consensus antigens, nucleic acid constructs and vacciens made therefrom, and methods of using same |
| US20190290750A1 (en) * | 2016-12-02 | 2019-09-26 | The Trustees Of The University Of Pennsylvania | Dna antibody constructs for use against ebola virus |
| CN110655572B (zh) * | 2019-10-11 | 2022-08-16 | 中国科学院广州生物医药与健康研究院 | 一种抗丝状病毒gp蛋白的单克隆抗体及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| KR102146904B1 (ko) | 2012-04-12 | 2020-08-24 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 필로바이러스 공통 항원, 이로부터 제조된 핵산 구조체 및 백신, 및 이를 사용하는 방법 |
| CN114045295A (zh) | 2013-03-15 | 2022-02-15 | 宾夕法尼亚大学理事会 | 口蹄疫病毒(fmdv)共有蛋白、其编码序列以及由其制造的疫苗 |
| JP6462861B2 (ja) * | 2014-09-03 | 2019-01-30 | バヴァリアン ノルディック エー／エス | フィロウイルス感染に対する防御免疫の誘導を目的とする方法及び組成物 |
| KR102586707B1 (ko) * | 2014-10-01 | 2023-10-11 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 항원 및 어쥬번트로서 인터류킨-21을 갖는 백신 |
| WO2017192947A1 (en) * | 2016-05-05 | 2017-11-09 | Weiner, David | Filovirus consensus antigens, nucleic acid constructs and vacciens made therefrom, and methods of using same |
-
2017
- 2017-05-05 WO PCT/US2017/031215 patent/WO2017192947A1/en unknown
- 2017-05-05 CN CN201780042299.9A patent/CN110072536B/zh active Active
- 2017-05-05 US US16/098,912 patent/US11091518B2/en active Active
- 2017-05-05 JP JP2019510571A patent/JP7029756B2/ja active Active
- 2017-05-05 SG SG10202011017RA patent/SG10202011017RA/en unknown
- 2017-05-05 AU AU2017261306A patent/AU2017261306B2/en active Active
- 2017-05-05 KR KR1020247020713A patent/KR20240099514A/ko active Search and Examination
- 2017-05-05 BR BR112018072719-9A patent/BR112018072719A2/pt unknown
- 2017-05-05 EP EP17793414.8A patent/EP3452068A4/en active Pending
- 2017-05-05 KR KR1020187035164A patent/KR102678400B1/ko active IP Right Grant
- 2017-05-05 SG SG11201809780WA patent/SG11201809780WA/en unknown
- 2017-05-05 CN CN202410055051.8A patent/CN117887735A/zh active Pending
- 2017-05-05 CA CA3023098A patent/CA3023098A1/en active Pending
- 2017-05-05 MX MX2018013524A patent/MX2018013524A/es unknown
-
2018
- 2018-11-05 MX MX2023003934A patent/MX2023003934A/es unknown
-
2021
- 2021-08-17 US US17/404,143 patent/US20210388033A1/en active Pending
-
2022
- 2022-02-10 JP JP2022019743A patent/JP2022078067A/ja active Pending
-
2024
- 2024-05-27 AU AU2024203524A patent/AU2024203524A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019516400A (ja) | 2019-06-20 |
| EP3452068A1 (en) | 2019-03-13 |
| KR20240099514A (ko) | 2024-06-28 |
| US20210388033A1 (en) | 2021-12-16 |
| US20190153040A1 (en) | 2019-05-23 |
| CN117887735A (zh) | 2024-04-16 |
| KR102678400B1 (ko) | 2024-06-26 |
| CN110072536A (zh) | 2019-07-30 |
| CN110072536B (zh) | 2024-02-02 |
| JP2022078067A (ja) | 2022-05-24 |
| SG10202011017RA (en) | 2020-12-30 |
| SG11201809780WA (en) | 2018-12-28 |
| JP7029756B2 (ja) | 2022-03-04 |
| WO2017192947A1 (en) | 2017-11-09 |
| EP3452068A4 (en) | 2020-01-22 |
| AU2017261306B2 (en) | 2024-02-29 |
| BR112018072719A2 (pt) | 2019-02-19 |
| US11091518B2 (en) | 2021-08-17 |
| AU2017261306A1 (en) | 2018-12-20 |
| KR20190037200A (ko) | 2019-04-05 |
| CA3023098A1 (en) | 2017-11-09 |
| MX2018013524A (es) | 2019-06-10 |
| AU2024203524A1 (en) | 2024-06-20 |
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