TR201907655T4 - Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses. - Google Patents

Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses. Download PDF

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Publication number
TR201907655T4
TR201907655T4 TR2019/07655T TR201907655T TR201907655T4 TR 201907655 T4 TR201907655 T4 TR 201907655T4 TR 2019/07655 T TR2019/07655 T TR 2019/07655T TR 201907655 T TR201907655 T TR 201907655T TR 201907655 T4 TR201907655 T4 TR 201907655T4
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TR
Turkey
Prior art keywords
amino acid
improved
production
microorganisms
amino acids
Prior art date
Application number
TR2019/07655T
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English (en)
Inventor
Sung Koh Eun
Yon Kwon Su
Ho Lee Kwang
Sun Lee Ji
Jang Juno
Cheol Lee Keun
Pyo Hong Hyeong
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Cj Cheiljedang Corp
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Application filed by Cj Cheiljedang Corp filed Critical Cj Cheiljedang Corp
Publication of TR201907655T4 publication Critical patent/TR201907655T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C12P13/227—Tryptophan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/26—Processes using, or culture media containing, hydrocarbons
    • C12N1/28—Processes using, or culture media containing, hydrocarbons aliphatic
    • C12N1/30—Processes using, or culture media containing, hydrocarbons aliphatic having five or less carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2497—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing N- glycosyl compounds (3.2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/02—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
    • C12Y302/02004—AMP nucleosidase (3.2.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Geliştirilmiş L-amino asit verimliliğine sahip bir rekombinant mikroorganizma, burada rekombinant mikroorganizma, adenozin deaminaz ve AMP nükleosidazın en az birinin giderilmiş veya azaltılmış aktivitesine sahip olmak için dönüştürülmektedir, ve rekombinant mikroorganizma kullanılarak bir L-amino asit üretmek için bir yöntem açıklanmaktadır. Rekombinant mikroorganizmanın kullanılması, oldukça etkili bir şekilde L-amino asit üretimi sağlayabilmektedir.
TR2019/07655T 2014-03-21 2015-03-17 Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses. TR201907655T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020140033698A KR101599800B1 (ko) 2014-03-21 2014-03-21 Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법

Publications (1)

Publication Number Publication Date
TR201907655T4 true TR201907655T4 (tr) 2019-06-21

Family

ID=54144919

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/07655T TR201907655T4 (tr) 2014-03-21 2015-03-17 Geliştirilmiş l-amino asit verimliliğine sahip mikroorganizmalar ve bunları kullanarak l-amino asitlerin üretilmesine yönelik proses.

Country Status (16)

Country Link
US (1) US10113191B2 (tr)
EP (1) EP3119874B1 (tr)
JP (1) JP6494643B2 (tr)
KR (1) KR101599800B1 (tr)
CN (1) CN105980545B (tr)
AR (1) AR099811A1 (tr)
BR (1) BR112016017592B1 (tr)
DK (1) DK3119874T3 (tr)
ES (1) ES2728970T3 (tr)
HU (1) HUE045306T2 (tr)
MY (1) MY180267A (tr)
PL (1) PL3119874T3 (tr)
TR (1) TR201907655T4 (tr)
TW (2) TWI639698B (tr)
UA (1) UA118276C2 (tr)
WO (1) WO2015142021A1 (tr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116254242B (zh) * 2022-12-21 2024-01-30 江南大学 一种atp磷酸核苷转移酶突变体及产l-组氨酸的谷氨酸棒杆菌

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837041T2 (de) 1997-07-18 2007-11-08 Ajinomoto Co., Inc. Verfahren und Mikroorganismus zur Herstellung von Purin-Nukleosiden durch Fermentation
KR100270510B1 (ko) * 1998-08-14 2000-11-01 고두모 신규 미생물 및 이를 이용한 엘- 쓰레오닌의 제조방법
RU2175351C2 (ru) * 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Фрагмент днк из escherichia coli, определяющий повышенную продукцию l-аминокислот (варианты), и способ получения l-аминокислот
JPWO2002097086A1 (ja) * 2001-05-29 2005-04-07 協和醗酵工業株式会社 工業的生産に有用な微生物
KR100792095B1 (ko) * 2006-12-29 2008-01-04 씨제이 주식회사 Ｌ-페닐알라닌 생산능을 갖는 대장균 변이주로부터유전자조작된 ｌ-트립토판 생산능을 갖는 재조합 대장균균주 및 이를 이용한 트립토판 제조방법
KR100966324B1 (ko) 2008-01-08 2010-06-28 씨제이제일제당 (주) 향상된 ｌ－쓰레오닌 생산능을 갖는 대장균 및 이를 이용한ｌ－쓰레오닌의 생산 방법
WO2009107631A1 (ja) 2008-02-25 2009-09-03 味の素株式会社 ５’－グアニル酸の製造法
CA2753495C (en) * 2009-02-26 2018-05-15 Advanced Cooling Therapy, Llc Devices and methods for controlling patient temperature
KR101261147B1 (ko) * 2011-01-18 2013-05-06 씨제이제일제당 (주) Ｌ-아미노산의 생산능이 향상된 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법
KR101327093B1 (ko) * 2012-01-06 2013-11-07 씨제이제일제당 (주) Ｌ-아미노산을 생산할 수 있는 미생물 및 이를 이용하여 ｌ-아미노산을 생산하는 방법

Also Published As

Publication number Publication date
BR112016017592A2 (pt) 2017-10-03
TW201734199A (zh) 2017-10-01
US10113191B2 (en) 2018-10-30
JP2017504349A (ja) 2017-02-09
JP6494643B2 (ja) 2019-04-03
EP3119874A4 (en) 2017-11-15
CN105980545A (zh) 2016-09-28
EP3119874B1 (en) 2019-05-08
CN105980545B (zh) 2019-12-24
WO2015142021A1 (en) 2015-09-24
EP3119874A1 (en) 2017-01-25
DK3119874T3 (da) 2019-07-22
BR112016017592B1 (pt) 2023-11-14
MY180267A (en) 2020-11-26
ES2728970T3 (es) 2019-10-29
UA118276C2 (uk) 2018-12-26
HUE045306T2 (hu) 2019-12-30
US20170002388A1 (en) 2017-01-05
KR101599800B1 (ko) 2016-03-04
PL3119874T3 (pl) 2019-10-31
KR20150109990A (ko) 2015-10-02
TWI639698B (zh) 2018-11-01
AR099811A1 (es) 2016-08-17
TW201538725A (zh) 2015-10-16

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