TR201901561T4 - Germanyumun kompleks bi̇leşi̇kleri̇, bunun üreti̇lmesi̇ne yöneli̇k yöntemler ve i̇laçlar. - Google Patents
Germanyumun kompleks bi̇leşi̇kleri̇, bunun üreti̇lmesi̇ne yöneli̇k yöntemler ve i̇laçlar. Download PDFInfo
- Publication number
- TR201901561T4 TR201901561T4 TR2019/01561T TR201901561T TR201901561T4 TR 201901561 T4 TR201901561 T4 TR 201901561T4 TR 2019/01561 T TR2019/01561 T TR 2019/01561T TR 201901561 T TR201901561 T TR 201901561T TR 201901561 T4 TR201901561 T4 TR 201901561T4
- Authority
- TR
- Turkey
- Prior art keywords
- acid
- germanium
- production
- produced
- derivative
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 229910052732 germanium Inorganic materials 0.000 abstract 3
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 abstract 1
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 abstract 1
- 229960004150 aciclovir Drugs 0.000 abstract 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960002963 ganciclovir Drugs 0.000 abstract 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1
- 229940119177 germanium dioxide Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229960001179 penciclovir Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
- 229940093257 valacyclovir Drugs 0.000 abstract 1
- 229960003636 vidarabine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/30—Germanium compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012120329/04A RU2487878C1 (ru) | 2012-05-16 | 2012-05-16 | Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201901561T4 true TR201901561T4 (tr) | 2019-02-21 |
Family
ID=48791166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/01561T TR201901561T4 (tr) | 2012-05-16 | 2012-11-01 | Germanyumun kompleks bi̇leşi̇kleri̇, bunun üreti̇lmesi̇ne yöneli̇k yöntemler ve i̇laçlar. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9745337B2 (https=) |
| EP (1) | EP2851368B1 (https=) |
| JP (1) | JP5993088B2 (https=) |
| KR (1) | KR101717280B1 (https=) |
| CN (1) | CN104302651B (https=) |
| AU (1) | AU2012380376B2 (https=) |
| BR (1) | BR112014027919B1 (https=) |
| CA (1) | CA2873390C (https=) |
| DK (1) | DK2851368T3 (https=) |
| ES (1) | ES2710915T3 (https=) |
| IN (1) | IN2014DN09234A (https=) |
| PL (1) | PL2851368T3 (https=) |
| PT (1) | PT2851368T (https=) |
| RU (1) | RU2487878C1 (https=) |
| TR (1) | TR201901561T4 (https=) |
| WO (1) | WO2013172732A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2626954C2 (ru) * | 2015-11-11 | 2017-08-02 | Общество С Ограниченной Ответственностью "Вдс Фарма" | Комплексные соединения германия с аминокислотами и липоевой кислотой |
| RU2752934C1 (ru) * | 2020-10-16 | 2021-08-11 | Александр Дмитриевич Исаев | Комплексные соединения германия с ациклическими полиолами и способ их получения |
| CN114133398B (zh) * | 2021-12-31 | 2022-11-22 | 中南民族大学 | 氨基酸取代的阿昔洛韦类三环核苷衍生物及其合成方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3616208A (en) * | 1967-09-29 | 1971-10-26 | Parke Davis & Co | Fermentation process for 9-(beta-d-arabinofuranosyl)adenine |
| JPS4924213B1 (https=) * | 1969-04-02 | 1974-06-21 | ||
| JPS4924213A (https=) | 1972-06-19 | 1974-03-04 | ||
| DE3212817A1 (de) * | 1982-04-06 | 1983-10-13 | Sanum-Kehlbeck GmbH & Co KG, 2812 Hoya | Pharmazeutisch wirksame organische germaniumverbindungen und verfahren zu deren herstellung |
| EP0477871A3 (en) | 1990-09-28 | 1992-12-02 | Nippon Kayaku Kabushiki Kaisha | Antiviral composition, containing guanine derivatives |
| CN1154359A (zh) * | 1996-01-12 | 1997-07-16 | 常达正 | 氨基酸锗的制备方法及其应用 |
| AU706703B2 (en) * | 1996-09-05 | 1999-06-24 | Primamedic Limited | 1,3-dicarboxylic germanium complex and its therapeutic use |
| RU2104032C1 (ru) * | 1997-03-11 | 1998-02-10 | Общество с ограниченной ответственностью "Снежный барс" | Способ усиления лечебного эффекта лекарственных средств |
| WO2000010561A1 (en) * | 1998-08-17 | 2000-03-02 | Evgeny Vladimirovich Soloviev | Bio-chemical germanium complexes with high therapeutic efficiency and wide application spectrum |
| ATE226441T1 (de) | 1999-02-22 | 2002-11-15 | Gernot Treusch | Therapeutisch wirksames stoffgemisch enthaltend s-acetylglutathion und aciclovir |
| RU2240792C2 (ru) | 2002-07-30 | 2004-11-27 | Государственное учреждение Научно-исследовательский институт вирусологии им. Д.И. Ивановского РАМН | Комбинации на основе нетропсина или его бис-производного, обладающие антигерпетической активностью |
| RU2233280C1 (ru) | 2003-03-25 | 2004-07-27 | Научно-исследовательский институт физической и органической химии Ростовского государственного университета | СОЛИ-10-ω-АРИЛОКСИАЛКИЛ-2,3,4,10-ТЕТРАГИДРОПИРИМИДО[1,2-A]БЕНЗИМИДАЗОЛА, ОБЛАДАЮЩИЕ МЕСТНОАНЕСТЕЗИРУЮЩИМ ДЕЙСТВИЕМ |
| DE10343365A1 (de) | 2003-09-17 | 2005-04-14 | Biosphings Ag | Pharmazeutische Formulierungen von Xanthogenaten und Hemmstoffen der viralen Nukleinsäurereplikation |
| RU2476436C1 (ru) * | 2012-01-25 | 2013-02-27 | Общество С Ограниченной Ответственностью "Вдс Фарма" | Комплексные соединения германия с аминокислотами и карбоновыми кислотами |
-
2012
- 2012-05-16 RU RU2012120329/04A patent/RU2487878C1/ru active
- 2012-11-01 AU AU2012380376A patent/AU2012380376B2/en not_active Ceased
- 2012-11-01 EP EP12876796.9A patent/EP2851368B1/en active Active
- 2012-11-01 JP JP2015512600A patent/JP5993088B2/ja active Active
- 2012-11-01 IN IN9234DEN2014 patent/IN2014DN09234A/en unknown
- 2012-11-01 PT PT12876796T patent/PT2851368T/pt unknown
- 2012-11-01 CN CN201280073187.7A patent/CN104302651B/zh active Active
- 2012-11-01 TR TR2019/01561T patent/TR201901561T4/tr unknown
- 2012-11-01 DK DK12876796.9T patent/DK2851368T3/en active
- 2012-11-01 ES ES12876796T patent/ES2710915T3/es active Active
- 2012-11-01 BR BR112014027919A patent/BR112014027919B1/pt active IP Right Grant
- 2012-11-01 CA CA2873390A patent/CA2873390C/en not_active Expired - Fee Related
- 2012-11-01 US US14/400,081 patent/US9745337B2/en active Active
- 2012-11-01 PL PL12876796T patent/PL2851368T3/pl unknown
- 2012-11-01 KR KR1020147035216A patent/KR101717280B1/ko active Active
- 2012-11-01 WO PCT/RU2012/000897 patent/WO2013172732A1/ru not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2851368A1 (en) | 2015-03-25 |
| JP5993088B2 (ja) | 2016-09-14 |
| WO2013172732A1 (ru) | 2013-11-21 |
| KR101717280B1 (ko) | 2017-03-17 |
| IN2014DN09234A (https=) | 2015-07-10 |
| US9745337B2 (en) | 2017-08-29 |
| ES2710915T3 (es) | 2019-04-29 |
| PT2851368T (pt) | 2019-02-11 |
| CN104302651B (zh) | 2017-04-12 |
| EP2851368B1 (en) | 2019-01-02 |
| CN104302651A (zh) | 2015-01-21 |
| BR112014027919A2 (pt) | 2017-06-27 |
| CA2873390C (en) | 2017-10-24 |
| PL2851368T3 (pl) | 2019-06-28 |
| DK2851368T3 (en) | 2019-02-25 |
| BR112014027919B1 (pt) | 2020-02-04 |
| EP2851368A4 (en) | 2016-02-10 |
| US20150126726A1 (en) | 2015-05-07 |
| AU2012380376B2 (en) | 2015-10-01 |
| RU2487878C1 (ru) | 2013-07-20 |
| JP2015518823A (ja) | 2015-07-06 |
| KR20150011386A (ko) | 2015-01-30 |
| CA2873390A1 (en) | 2013-11-21 |
| AU2012380376A1 (en) | 2014-12-04 |
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