TR201901561T4 - Germanyumun kompleks bi̇leşi̇kleri̇, bunun üreti̇lmesi̇ne yöneli̇k yöntemler ve i̇laçlar. - Google Patents
Germanyumun kompleks bi̇leşi̇kleri̇, bunun üreti̇lmesi̇ne yöneli̇k yöntemler ve i̇laçlar. Download PDFInfo
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- TR201901561T4 TR201901561T4 TR2019/01561T TR201901561T TR201901561T4 TR 201901561 T4 TR201901561 T4 TR 201901561T4 TR 2019/01561 T TR2019/01561 T TR 2019/01561T TR 201901561 T TR201901561 T TR 201901561T TR 201901561 T4 TR201901561 T4 TR 201901561T4
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- Prior art keywords
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- germanium
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- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 229910052732 germanium Inorganic materials 0.000 abstract 3
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- 239000004475 Arginine Substances 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 abstract 1
- OIRDTQYFTABQOQ-UHTZMRCNSA-N Vidarabine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O OIRDTQYFTABQOQ-UHTZMRCNSA-N 0.000 abstract 1
- 229960004150 aciclovir Drugs 0.000 abstract 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001371 alpha-amino acids Chemical class 0.000 abstract 1
- 235000008206 alpha-amino acids Nutrition 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960002963 ganciclovir Drugs 0.000 abstract 1
- IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 abstract 1
- 229940119177 germanium dioxide Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229960001179 penciclovir Drugs 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
- 229940093257 valacyclovir Drugs 0.000 abstract 1
- 229960003636 vidarabine Drugs 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/30—Germanium compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Buluş, özellikle herpes virüslerinin neden olduğu viral hastalıkların profilaksisi ve/veya tedavisi için hedeflenen ilaçların geliştirilmesi ile ilgilidir. Önerilenler, genel yapısal formüle sahip olan germanyumun kompleks bileşikleridir: Gex[AD][CA]y[AA]z (I), burada AD, antiviral aktiviteye sahip olan purin dizilerinin bir nitrojenli baz türevidir ve asiklovir, valasiklovir, gansiklovir ve pensiklovir gibi guanin türevlerinden veya vidarabin gibi adenin türevlerinden seçilebilir; CA, (bunlarla sınırlı olmamak üzere) sitrik asit, laktik asit ve malik asit gibi asitlerden seçilebilen bir hidroksikarboksilik asittir; AA, arjinin, glisin, lizin ve treonin gibi a-amino asitlerden seçilebilen bir amino asittir ve burada x = 1-2, y = 2-4 ve z = 0-2'dir. Germanyumun kompleks bileşikleri, yüksek seviyede bir antiviral ve immün stimüle edici aktiviteye sahiptir ve su içinde kolay bir şekilde çözünebilir. Yukarıda geçen bileşikler, germanyum dioksitin bir aköz süspansiyonun üretilmesi, bir hidrokarboksilik asit, purin dizilerinin bir nitrojen bazının bir türevi ve isteğe bağlı olarak ancak tercihen bir amino asidin buna eklenmesi, karıştırılırken ve solüsyondan su uzaklaştırılırken 3-14 saat 40-100°C sıcaklıkta üretilen karışımın ısıtılması, böylece germanyumun bir kompleks bileşiğinin üretilmesi aracılığıyla üretilir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012120329/04A RU2487878C1 (ru) | 2012-05-16 | 2012-05-16 | Комплексные соединения германия с производными азотистых оснований пуринового ряда, способы их получения и содержащие их лекарственные средства |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201901561T4 true TR201901561T4 (tr) | 2019-02-21 |
Family
ID=48791166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/01561T TR201901561T4 (tr) | 2012-05-16 | 2012-11-01 | Germanyumun kompleks bi̇leşi̇kleri̇, bunun üreti̇lmesi̇ne yöneli̇k yöntemler ve i̇laçlar. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9745337B2 (tr) |
| EP (1) | EP2851368B1 (tr) |
| JP (1) | JP5993088B2 (tr) |
| KR (1) | KR101717280B1 (tr) |
| CN (1) | CN104302651B (tr) |
| AU (1) | AU2012380376B2 (tr) |
| BR (1) | BR112014027919B1 (tr) |
| CA (1) | CA2873390C (tr) |
| DK (1) | DK2851368T3 (tr) |
| ES (1) | ES2710915T3 (tr) |
| IN (1) | IN2014DN09234A (tr) |
| PL (1) | PL2851368T3 (tr) |
| PT (1) | PT2851368T (tr) |
| RU (1) | RU2487878C1 (tr) |
| TR (1) | TR201901561T4 (tr) |
| WO (1) | WO2013172732A1 (tr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2626954C2 (ru) * | 2015-11-11 | 2017-08-02 | Общество С Ограниченной Ответственностью "Вдс Фарма" | Комплексные соединения германия с аминокислотами и липоевой кислотой |
| RU2752934C1 (ru) * | 2020-10-16 | 2021-08-11 | Александр Дмитриевич Исаев | Комплексные соединения германия с ациклическими полиолами и способ их получения |
| CN114133398B (zh) * | 2021-12-31 | 2022-11-22 | 中南民族大学 | 氨基酸取代的阿昔洛韦类三环核苷衍生物及其合成方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3616208A (en) * | 1967-09-29 | 1971-10-26 | Parke Davis & Co | Fermentation process for 9-(beta-d-arabinofuranosyl)adenine |
| JPS4924213B1 (tr) * | 1969-04-02 | 1974-06-21 | ||
| JPS4924213A (tr) | 1972-06-19 | 1974-03-04 | ||
| DE3212817A1 (de) * | 1982-04-06 | 1983-10-13 | Sanum-Kehlbeck GmbH & Co KG, 2812 Hoya | Pharmazeutisch wirksame organische germaniumverbindungen und verfahren zu deren herstellung |
| EP0477871A3 (en) | 1990-09-28 | 1992-12-02 | Nippon Kayaku Kabushiki Kaisha | Antiviral composition, containing guanine derivatives |
| CN1154359A (zh) * | 1996-01-12 | 1997-07-16 | 常达正 | 氨基酸锗的制备方法及其应用 |
| EP0931084B1 (en) * | 1996-09-05 | 2002-02-06 | Primamedic Limited | 1,3-dicarboxylic germanium complex and its therapeutic use |
| RU2104032C1 (ru) * | 1997-03-11 | 1998-02-10 | Общество с ограниченной ответственностью "Снежный барс" | Способ усиления лечебного эффекта лекарственных средств |
| WO2000010561A1 (en) * | 1998-08-17 | 2000-03-02 | Evgeny Vladimirovich Soloviev | Bio-chemical germanium complexes with high therapeutic efficiency and wide application spectrum |
| AU3424500A (en) | 1999-02-22 | 2000-09-14 | Gernot Treusch | Therapeutically active mixture of substances containing s-acetylglutathione and aciclovir |
| RU2240792C2 (ru) | 2002-07-30 | 2004-11-27 | Государственное учреждение Научно-исследовательский институт вирусологии им. Д.И. Ивановского РАМН | Комбинации на основе нетропсина или его бис-производного, обладающие антигерпетической активностью |
| RU2233280C1 (ru) | 2003-03-25 | 2004-07-27 | Научно-исследовательский институт физической и органической химии Ростовского государственного университета | СОЛИ-10-ω-АРИЛОКСИАЛКИЛ-2,3,4,10-ТЕТРАГИДРОПИРИМИДО[1,2-A]БЕНЗИМИДАЗОЛА, ОБЛАДАЮЩИЕ МЕСТНОАНЕСТЕЗИРУЮЩИМ ДЕЙСТВИЕМ |
| DE10343365A1 (de) | 2003-09-17 | 2005-04-14 | Biosphings Ag | Pharmazeutische Formulierungen von Xanthogenaten und Hemmstoffen der viralen Nukleinsäurereplikation |
| RU2476436C1 (ru) * | 2012-01-25 | 2013-02-27 | Общество С Ограниченной Ответственностью "Вдс Фарма" | Комплексные соединения германия с аминокислотами и карбоновыми кислотами |
-
2012
- 2012-05-16 RU RU2012120329/04A patent/RU2487878C1/ru active
- 2012-11-01 CA CA2873390A patent/CA2873390C/en not_active Expired - Fee Related
- 2012-11-01 TR TR2019/01561T patent/TR201901561T4/tr unknown
- 2012-11-01 IN IN9234DEN2014 patent/IN2014DN09234A/en unknown
- 2012-11-01 CN CN201280073187.7A patent/CN104302651B/zh active Active
- 2012-11-01 EP EP12876796.9A patent/EP2851368B1/en active Active
- 2012-11-01 DK DK12876796.9T patent/DK2851368T3/en active
- 2012-11-01 JP JP2015512600A patent/JP5993088B2/ja active Active
- 2012-11-01 PT PT12876796T patent/PT2851368T/pt unknown
- 2012-11-01 WO PCT/RU2012/000897 patent/WO2013172732A1/ru active Application Filing
- 2012-11-01 PL PL12876796T patent/PL2851368T3/pl unknown
- 2012-11-01 AU AU2012380376A patent/AU2012380376B2/en not_active Ceased
- 2012-11-01 ES ES12876796T patent/ES2710915T3/es active Active
- 2012-11-01 KR KR1020147035216A patent/KR101717280B1/ko active IP Right Grant
- 2012-11-01 US US14/400,081 patent/US9745337B2/en active Active
- 2012-11-01 BR BR112014027919A patent/BR112014027919B1/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PL2851368T3 (pl) | 2019-06-28 |
| CA2873390C (en) | 2017-10-24 |
| IN2014DN09234A (tr) | 2015-07-10 |
| CA2873390A1 (en) | 2013-11-21 |
| KR101717280B1 (ko) | 2017-03-17 |
| BR112014027919A2 (pt) | 2017-06-27 |
| BR112014027919B1 (pt) | 2020-02-04 |
| US20150126726A1 (en) | 2015-05-07 |
| ES2710915T3 (es) | 2019-04-29 |
| AU2012380376B2 (en) | 2015-10-01 |
| EP2851368A1 (en) | 2015-03-25 |
| AU2012380376A1 (en) | 2014-12-04 |
| DK2851368T3 (en) | 2019-02-25 |
| KR20150011386A (ko) | 2015-01-30 |
| CN104302651A (zh) | 2015-01-21 |
| RU2487878C1 (ru) | 2013-07-20 |
| EP2851368A4 (en) | 2016-02-10 |
| EP2851368B1 (en) | 2019-01-02 |
| PT2851368T (pt) | 2019-02-11 |
| WO2013172732A1 (ru) | 2013-11-21 |
| JP2015518823A (ja) | 2015-07-06 |
| US9745337B2 (en) | 2017-08-29 |
| JP5993088B2 (ja) | 2016-09-14 |
| CN104302651B (zh) | 2017-04-12 |
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