TR200103858T2 - Hücre yapışmasının önleyicileri olarak ikame edilmiş purin türevleri - Google Patents

Hücre yapışmasının önleyicileri olarak ikame edilmiş purin türevleri

Info

Publication number
TR200103858T2
TR200103858T2 TR2001/03858T TR200103858T TR200103858T2 TR 200103858 T2 TR200103858 T2 TR 200103858T2 TR 2001/03858 T TR2001/03858 T TR 2001/03858T TR 200103858 T TR200103858 T TR 200103858T TR 200103858 T2 TR200103858 T2 TR 200103858T2
Authority
TR
Turkey
Prior art keywords
inhibitors
cell
cell adhesion
purine derivatives
derivatives substituted
Prior art date
Application number
TR2001/03858T
Other languages
English (en)
Inventor
Peyman Anuschirwan
Knolle Jochen
R. Gadek Thomas
Gourvest Jean-Francois
Ruxer Jean-Marie
Original Assignee
Aventis Pharma Deutschland Gmbh
Genentech, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh, Genentech, Inc filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200103858T2 publication Critical patent/TR200103858T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Mevcut bulus, B, D, E, G, X, Y, Z, R1, R2, ve s' nin istemlerde belirtilen anlamlara geldigi formül (I)' e ait bilesiklerle, bunlarin fizyolojik açidan tolere edilebilir tuzlari ve ön ilaçlariyla ilgilidir. Formül (I)' e ait bilesikler, farmakolojik açidan aktif degerli bilesiklerdir. Bunlar, vitronektin alici antagonistleri ve hücre yapismasinin önleyicileridir ve bunlar, hücre-hücre veya hücre-matris etkilesim süreçlerinde vitonektin alicilari ile bunlarin ligantlari arasindaki etkilesime dayanan veya bu etkilesimlerin etkilenmesiyle önlenebilen, iyilestirilebilen veya tedavi edilebilen hastaliklarin terapisi ve profilaksisi için uygundur.
TR2001/03858T 1999-07-02 2000-06-26 Hücre yapışmasının önleyicileri olarak ikame edilmiş purin türevleri TR200103858T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99112637A EP1065208A1 (en) 1999-07-02 1999-07-02 Substituted purine derivatives as inhibitors of cell adhesion

Publications (1)

Publication Number Publication Date
TR200103858T2 true TR200103858T2 (tr) 2002-06-21

Family

ID=8238483

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03858T TR200103858T2 (tr) 1999-07-02 2000-06-26 Hücre yapışmasının önleyicileri olarak ikame edilmiş purin türevleri

Country Status (30)

Country Link
US (1) US6747016B1 (tr)
EP (2) EP1065208A1 (tr)
JP (1) JP2003503497A (tr)
KR (1) KR20020015997A (tr)
CN (1) CN1171888C (tr)
AR (1) AR034242A1 (tr)
AT (1) ATE262528T1 (tr)
AU (1) AU774382B2 (tr)
BG (1) BG106229A (tr)
BR (1) BR0012050A (tr)
CA (1) CA2376673A1 (tr)
CZ (1) CZ20014553A3 (tr)
DE (1) DE60009296T2 (tr)
EA (1) EA005372B1 (tr)
EE (1) EE200100713A (tr)
ES (1) ES2219353T3 (tr)
HU (1) HUP0300183A3 (tr)
IL (1) IL147245A0 (tr)
MX (1) MXPA01013241A (tr)
MY (1) MY122631A (tr)
NO (1) NO20016403L (tr)
NZ (1) NZ516095A (tr)
PL (1) PL352281A1 (tr)
SK (1) SK18792001A3 (tr)
TR (1) TR200103858T2 (tr)
TW (1) TWI229080B (tr)
UA (1) UA72923C2 (tr)
WO (1) WO2001002399A1 (tr)
YU (1) YU89701A (tr)
ZA (1) ZA200200017B (tr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10042655A1 (de) 2000-08-31 2002-03-14 Aventis Pharma Gmbh Verfahren zur Herstellung von Inhibitoren der Zell-Adhäsion
FR2847254B1 (fr) 2002-11-19 2005-01-28 Aventis Pharma Sa Nouveaux derives antagonistes du recepteur de la vitronectine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les refermant
FR2870541B1 (fr) 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
ES2684821T3 (es) * 2005-12-29 2018-10-04 Lexicon Pharmaceuticals, Inc. Derivados de aminoácidos multicíclicos y métodos de su uso
CL2007002994A1 (es) * 2006-10-19 2008-02-08 Wyeth Corp Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros.
CN107450106A (zh) * 2017-09-28 2017-12-08 北京小米移动软件有限公司 饮水安全提示方法、装置及智能水杯
AU2021267373A1 (en) 2020-05-06 2022-12-08 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
EP4430042A1 (en) 2021-11-09 2024-09-18 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2190870A1 (en) * 1994-05-27 1995-12-07 George D. Hartman Compounds for inhibiting osteoclast-mediated bone resorption
AU724191B2 (en) * 1996-08-29 2000-09-14 Merck & Co., Inc. Integrin antagonists
EP0946164A4 (en) * 1996-10-30 2000-08-23 Merck & Co Inc INTEGRIN ANTAGONISTS
DE19653646A1 (de) * 1996-12-20 1998-06-25 Hoechst Ag Substituierte Purinderivate, Verfahren zu deren Herstellung, sie enthaltende Mittel und deren Verwendung
CA2277273C (en) * 1997-01-17 2008-03-25 Merck & Co., Inc. Integrin antagonists
SK10632000A3 (sk) * 1998-01-23 2001-02-12 Aventis Pharma Deutschland Gmbh Sulfónamidové deriváty ako inhibítory resorpcie kostí a inhibítory bunkovej adhézie
WO1999038621A1 (en) 1998-01-28 1999-08-05 Danmist Aps Method of piezoelectrically atomising and pumping fluids and piezoelectric fluid atomising and pumping device

Also Published As

Publication number Publication date
BG106229A (bg) 2002-08-30
EA200200121A1 (ru) 2002-06-27
UA72923C2 (uk) 2005-05-16
CZ20014553A3 (cs) 2002-06-12
TWI229080B (en) 2005-03-11
HUP0300183A3 (en) 2005-12-28
IL147245A0 (en) 2002-08-14
EP1065208A1 (en) 2001-01-03
HUP0300183A2 (hu) 2003-06-28
NO20016403L (no) 2002-03-01
BR0012050A (pt) 2002-12-31
ES2219353T3 (es) 2004-12-01
MXPA01013241A (es) 2002-06-21
EP1196416A1 (en) 2002-04-17
AU5534900A (en) 2001-01-22
CN1371376A (zh) 2002-09-25
DE60009296D1 (de) 2004-04-29
EP1196416B1 (en) 2004-03-24
KR20020015997A (ko) 2002-03-02
ATE262528T1 (de) 2004-04-15
CA2376673A1 (en) 2001-01-11
NZ516095A (en) 2004-08-27
ZA200200017B (en) 2003-01-02
JP2003503497A (ja) 2003-01-28
CN1171888C (zh) 2004-10-20
NO20016403D0 (no) 2001-12-28
MY122631A (en) 2006-04-29
WO2001002399A1 (en) 2001-01-11
PL352281A1 (en) 2003-08-11
EE200100713A (et) 2003-04-15
US6747016B1 (en) 2004-06-08
YU89701A (sh) 2004-09-03
SK18792001A3 (sk) 2002-07-02
EA005372B1 (ru) 2005-02-24
AU774382B2 (en) 2004-06-24
DE60009296T2 (de) 2005-05-25
AR034242A1 (es) 2004-02-18

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