TR200103278T2 - Spiroimidazolidin türevleri, hazırlanışları, kullanışları ve bunları içeren farmasötik preparatlar. - Google Patents
Spiroimidazolidin türevleri, hazırlanışları, kullanışları ve bunları içeren farmasötik preparatlar.Info
- Publication number
- TR200103278T2 TR200103278T2 TR2001/03278T TR200103278T TR200103278T2 TR 200103278 T2 TR200103278 T2 TR 200103278T2 TR 2001/03278 T TR2001/03278 T TR 2001/03278T TR 200103278 T TR200103278 T TR 200103278T TR 200103278 T2 TR200103278 T2 TR 200103278T2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Mevcut bulus, E, V, W, X, R1 ve R2 nin istemlerde belirtilen anlamlara sahip oldugu formül I'in spiroimidazolidin türevleri ile ilgilidir. Formül (I)'in bilesikleri, örnegin; romatoid artrit ya da alerjik bozukluklar gibi enflamatuvar hastaliklarin tedavisi ya da profilaksisi için uygun olan, farmasötik açidan aktif olan degerli bilesiklerdir. Formül (I)'in bilesikleri, lökositlerin yapisma ve hücre göçü inhibitörleri ve/veya integrinler grubuna ait olan VLA-4 yapisma reseptörü antagonistleridir. Bunlar genellikle, lökosit yapismasi ve/veya lökosit göçünün istenmeyen sonuçlarinin neden oldugu ya da bunlar ile iliskili hastaliklarin ya da VLA-4 reseptörlerinin etkilesimlerine dayanan hücre-hücre veya hücre-matrisk etkilesimlerinin rol oynadigi durumlarinin tedavisi ve profilaksisi için uygundurlar.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19922462A DE19922462A1 (de) | 1999-05-17 | 1999-05-17 | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200103278T2 true TR200103278T2 (tr) | 2002-04-22 |
Family
ID=7908208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/03278T TR200103278T2 (tr) | 1999-05-17 | 2000-05-06 | Spiroimidazolidin türevleri, hazırlanışları, kullanışları ve bunları içeren farmasötik preparatlar. |
Country Status (28)
Country | Link |
---|---|
US (1) | US6399643B1 (tr) |
EP (1) | EP1183241B1 (tr) |
JP (1) | JP4686029B2 (tr) |
KR (1) | KR100658962B1 (tr) |
CN (1) | CN1221535C (tr) |
AR (1) | AR023989A1 (tr) |
AT (1) | ATE250038T1 (tr) |
AU (1) | AU778814B2 (tr) |
BR (1) | BR0011296B1 (tr) |
CA (1) | CA2373433C (tr) |
CZ (1) | CZ301467B6 (tr) |
DE (2) | DE19922462A1 (tr) |
DK (1) | DK1183241T3 (tr) |
ES (1) | ES2204595T3 (tr) |
HK (1) | HK1047104B (tr) |
HU (1) | HU228917B1 (tr) |
IL (2) | IL146276A0 (tr) |
MX (1) | MXPA01011611A (tr) |
NO (1) | NO320687B1 (tr) |
NZ (1) | NZ515496A (tr) |
PL (1) | PL201421B1 (tr) |
PT (1) | PT1183241E (tr) |
RU (1) | RU2245879C2 (tr) |
SI (1) | SI1183241T1 (tr) |
TR (1) | TR200103278T2 (tr) |
TW (1) | TWI256386B (tr) |
WO (1) | WO2000069831A1 (tr) |
ZA (1) | ZA200109370B (tr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10111877A1 (de) * | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE10134366A1 (de) * | 2001-07-14 | 2003-01-23 | Aventis Pharma Gmbh | Verfahren zur Herstellung der enantiomeren Formen von 2-substituierten 2-(2,5-Dioxoimidazolidin-l-yl)-essigsäure- Derivaten |
DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
SI3326645T1 (sl) | 2010-10-25 | 2020-09-30 | Biogen Ma Inc. | Metode za determinacijo razlik v alfa- 4 integrin aktivnosti s korelacijo razlik v SVCAM in/ali SMADCAM nivojih |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4009506A1 (de) | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
DE4126277A1 (de) | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
DE69309044T3 (de) | 1992-01-13 | 2004-12-23 | Biogen, Inc., Cambridge | Behandlung von asthma |
ATE151642T1 (de) | 1992-02-12 | 1997-05-15 | Biogen Inc | Behandlung für entzündungserkrankung des darmes |
DE4207254A1 (de) | 1992-03-07 | 1993-09-09 | Cassella Ag | 4-oxo-2-thioxoimidazolidin-derivate |
DE4213634A1 (de) | 1992-04-24 | 1993-10-28 | Cassella Ag | 2,4-Dioxo-imidazolidin-Derivate |
DE4224414A1 (de) | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
DE4228717A1 (de) | 1992-08-28 | 1994-03-03 | Cassella Ag | Imidazolidin-Derivate |
JPH08505628A (ja) | 1993-01-08 | 1996-06-18 | 田辺製薬株式会社 | ペプチド型細胞接着阻害薬 |
NZ261259A (en) | 1993-01-12 | 1996-12-20 | Biogen Inc | Humanised recombinant anti-vla4 antibody and diagnostic compositions and medicaments |
DK0682529T4 (da) | 1993-02-09 | 2006-05-15 | Biogen Idec Inc | Antistof til behandling af insulinkrævende diabetes |
DE4308034A1 (de) | 1993-03-13 | 1994-09-15 | Cassella Ag | Neue Heterocyclen, ihre Herstellung und ihre Verwendung |
DE4427979A1 (de) | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
AU693143B2 (en) | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
ES2424292T3 (es) | 1994-01-25 | 2013-09-30 | Biogen Idec Ma Inc. | Anticuerpos humanizados contra la molécula de adhesión leucocitaria VLA-4 |
EP0767674A4 (en) | 1994-06-29 | 1999-06-16 | Texas Biotechnology Corp | METHOD FOR INHIBITING THE BINDING OF INTEGRIN ALPHA 4 BETA 1 TO VCAM-1 OR FIBRONECTIN |
US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
ATE212990T1 (de) | 1996-03-20 | 2002-02-15 | Hoechst Ag | Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten |
KR20040084945A (ko) | 1996-07-25 | 2004-10-06 | 바이오겐 아이덱 엠에이 인코포레이티드 | 세포 유착 억제제 |
PL323130A1 (en) * | 1996-11-15 | 1998-05-25 | Hoechst Ag | Application of heterocyclic compounds in production of a pharmaceutic agent, novel heterocyclic compounds and pharmaceutic agent as such |
DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19647381A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
DE19648053C1 (de) | 1996-11-20 | 1998-03-12 | Siemens Ag | Elektromagnetisches Schaltgerät |
WO1998042656A1 (en) | 1997-03-21 | 1998-10-01 | Cytel Corporation | Novel compounds |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) * | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) * | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
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1999
- 1999-05-17 DE DE19922462A patent/DE19922462A1/de not_active Withdrawn
-
2000
- 2000-05-06 IL IL14627600A patent/IL146276A0/xx active IP Right Grant
- 2000-05-06 AT AT00929509T patent/ATE250038T1/de active
- 2000-05-06 CN CNB00809103XA patent/CN1221535C/zh not_active Expired - Fee Related
- 2000-05-06 NZ NZ515496A patent/NZ515496A/en not_active IP Right Cessation
- 2000-05-06 KR KR1020017014612A patent/KR100658962B1/ko not_active IP Right Cessation
- 2000-05-06 TR TR2001/03278T patent/TR200103278T2/tr unknown
- 2000-05-06 DE DE60005337T patent/DE60005337T2/de not_active Expired - Lifetime
- 2000-05-06 DK DK00929509T patent/DK1183241T3/da active
- 2000-05-06 WO PCT/EP2000/004090 patent/WO2000069831A1/en active IP Right Grant
- 2000-05-06 HU HU0202364A patent/HU228917B1/hu not_active IP Right Cessation
- 2000-05-06 RU RU2001133735/04A patent/RU2245879C2/ru not_active IP Right Cessation
- 2000-05-06 AU AU47560/00A patent/AU778814B2/en not_active Ceased
- 2000-05-06 SI SI200030244T patent/SI1183241T1/xx unknown
- 2000-05-06 BR BRPI0011296-8A patent/BR0011296B1/pt not_active IP Right Cessation
- 2000-05-06 PL PL351755A patent/PL201421B1/pl unknown
- 2000-05-06 CZ CZ20014089A patent/CZ301467B6/cs not_active IP Right Cessation
- 2000-05-06 CA CA2373433A patent/CA2373433C/en not_active Expired - Fee Related
- 2000-05-06 EP EP00929509A patent/EP1183241B1/en not_active Expired - Lifetime
- 2000-05-06 JP JP2000618248A patent/JP4686029B2/ja not_active Expired - Fee Related
- 2000-05-06 PT PT00929509T patent/PT1183241E/pt unknown
- 2000-05-06 MX MXPA01011611A patent/MXPA01011611A/es active IP Right Grant
- 2000-05-06 ES ES00929509T patent/ES2204595T3/es not_active Expired - Lifetime
- 2000-05-15 AR ARP000102331A patent/AR023989A1/es active IP Right Grant
- 2000-05-17 US US09/572,273 patent/US6399643B1/en not_active Expired - Lifetime
- 2000-06-22 TW TW089109207A patent/TWI256386B/zh not_active IP Right Cessation
-
2001
- 2001-11-01 IL IL146276A patent/IL146276A/en not_active IP Right Cessation
- 2001-11-14 ZA ZA200109370A patent/ZA200109370B/en unknown
- 2001-11-16 NO NO20015617A patent/NO320687B1/no not_active IP Right Cessation
-
2002
- 2002-11-29 HK HK02108687.9A patent/HK1047104B/zh not_active IP Right Cessation
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