TR200103545T2 - Dolastatin 15-türevleri. - Google Patents

Dolastatin 15-türevleri.

Info

Publication number
TR200103545T2
TR200103545T2 TR2001/03545T TR200103545T TR200103545T2 TR 200103545 T2 TR200103545 T2 TR 200103545T2 TR 2001/03545 T TR2001/03545 T TR 2001/03545T TR 200103545 T TR200103545 T TR 200103545T TR 200103545 T2 TR200103545 T2 TR 200103545T2
Authority
TR
Turkey
Prior art keywords
group
monovalent
mammal
amino
formula
Prior art date
Application number
TR2001/03545T
Other languages
English (en)
Turkish (tr)
Inventor
Janssen Bernd
Barlozzari Teresa
Haupt Andreas
Zierke Thomas
Kling Andreas
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR200103545T2 publication Critical patent/TR200103545T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
TR2001/03545T 1997-07-18 1998-07-07 Dolastatin 15-türevleri. TR200103545T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
TR200103545T2 true TR200103545T2 (tr) 2002-06-21

Family

ID=25406130

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2001/03545T TR200103545T2 (tr) 1997-07-18 1998-07-07 Dolastatin 15-türevleri.
TR2000/00132T TR200000132T2 (tr) 1997-07-18 1998-07-07 Dolastatin 15 türevleri

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2000/00132T TR200000132T2 (tr) 1997-07-18 1998-07-07 Dolastatin 15 türevleri

Country Status (32)

Country Link
US (6) US6143721A (OSRAM)
EP (1) EP0991658B1 (OSRAM)
JP (4) JP4508413B2 (OSRAM)
KR (1) KR100579748B1 (OSRAM)
CN (1) CN1268636C (OSRAM)
AR (1) AR018501A1 (OSRAM)
AT (1) ATE314387T1 (OSRAM)
AU (1) AU750120B2 (OSRAM)
BG (1) BG65212B1 (OSRAM)
BR (1) BR9810911A (OSRAM)
CA (1) CA2296036C (OSRAM)
CO (1) CO4990967A1 (OSRAM)
CY (1) CY1107047T1 (OSRAM)
CZ (1) CZ303045B6 (OSRAM)
DE (1) DE69832982T2 (OSRAM)
DK (1) DK0991658T3 (OSRAM)
ES (1) ES2258819T3 (OSRAM)
HR (1) HRP980397A2 (OSRAM)
HU (1) HU228996B1 (OSRAM)
ID (1) ID24669A (OSRAM)
IL (1) IL133784A (OSRAM)
MY (1) MY135057A (OSRAM)
NO (1) NO326827B1 (OSRAM)
NZ (1) NZ502296A (OSRAM)
PL (1) PL197884B1 (OSRAM)
PT (1) PT991658E (OSRAM)
RU (1) RU2195462C2 (OSRAM)
SK (1) SK286581B6 (OSRAM)
TR (2) TR200103545T2 (OSRAM)
TW (1) TW533217B (OSRAM)
WO (1) WO1999003879A1 (OSRAM)
ZA (1) ZA986358B (OSRAM)

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US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686336B2 (en) 2000-02-08 2004-02-03 Federal Government As Represented By The Department Of Veterans Affaires N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
RU2342399C2 (ru) * 2002-03-22 2008-12-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные гемиастерлина и их применение при лечении рака
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
PT2357006E (pt) 2002-07-31 2016-01-22 Seattle Genetics Inc Conjugados de fármacos e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infeciosa
SG149815A1 (en) 2003-11-06 2009-02-27 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
US20060148014A1 (en) * 2004-12-09 2006-07-06 Sergei Agoulnik Tubulin isotype screening in cancer therapy using hemiasterlin analogs
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
MY159563A (en) 2006-05-16 2017-01-13 Pharmascience Inc Iap bir domain binding compounds
CN106432496B (zh) 2007-07-16 2020-02-07 健泰科生物技术公司 抗cd79b抗体和免疫偶联物及使用方法
AR067543A1 (es) 2007-07-16 2009-10-14 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
EP2247620B1 (en) 2008-01-31 2016-05-18 Genentech, Inc. Anti-cd79b antibodies and immunoconjugates and methods of use
AR079528A1 (es) * 2009-12-18 2012-02-01 Idenix Pharmaceuticals Inc Inhibidores de arileno o heteroarileno 5,5-fusionado del virus de la hepatitis c
AU2011215900A1 (en) 2010-02-10 2012-07-26 Immunogen, Inc. CD20 antibodies and uses thereof
KR20120140658A (ko) 2010-02-12 2012-12-31 파마사이언스 인크. Ｉａｐ ｂｉｒ 도메인 결합 화합물
JP6133431B2 (ja) 2012-11-24 2017-05-24 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用
PT3122757T (pt) 2014-02-28 2023-11-03 Hangzhou Dac Biotech Co Ltd Ligantes carregados e as suas utilizações em conjugação
SI3262071T1 (sl) 2014-09-23 2020-07-31 F. Hoffmann-La Roche Ag Način uporabe imunokonjugatov proti CD79b
CN112125929A (zh) 2015-06-15 2020-12-25 杭州多禧生物科技有限公司 用于偶联的亲水链接体
AU2015242213A1 (en) 2015-07-12 2018-03-08 Hangzhou Dac Biotech Co., Ltd Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR20220147720A (ko) 2016-11-14 2022-11-03 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
EP4400121A1 (en) 2021-09-03 2024-07-17 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer
EP4426727A2 (en) 2021-11-03 2024-09-11 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
ATE215962T1 (de) * 1991-08-09 2002-04-15 Teikoku Hormone Mfg Co Ltd Tetrapeptide derivat
US5448045A (en) * 1992-02-26 1995-09-05 Clark; Paul C. System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
DE69320339T2 (de) * 1992-05-20 1998-12-17 Basf Ag, 67063 Ludwigshafen Derivate des Dolastatin
RU2132334C1 (ru) * 1992-12-16 1999-06-27 Басф Акциенгезельшафт Аналог долостатина
US5554993A (en) * 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) * 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) * 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US6104815A (en) * 1997-01-10 2000-08-15 Silicon Gaming, Inc. Method and apparatus using geographical position and universal time determination means to provide authenticated, secure, on-line communication between remote gaming locations
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) * 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) * 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) * 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
US7084110B2 (en) 2006-08-01
TR200000132T2 (tr) 2000-05-22
EP0991658B1 (en) 2005-12-28
KR100579748B1 (ko) 2006-05-15
WO1999003879A1 (en) 1999-01-28
CZ303045B6 (cs) 2012-03-07
HU228996B1 (hu) 2013-07-29
HK1029125A1 (en) 2001-03-23
HUP0004234A3 (en) 2001-08-28
DE69832982D1 (de) 2006-02-02
ZA986358B (en) 2000-01-17
US6143721A (en) 2000-11-07
PL338144A1 (en) 2000-09-25
CN1268636C (zh) 2006-08-09
JP2009137968A (ja) 2009-06-25
PT991658E (pt) 2006-05-31
US20130046077A1 (en) 2013-02-21
ES2258819T3 (es) 2006-09-01
AU8475898A (en) 1999-02-10
SK286581B6 (sk) 2009-01-07
CA2296036C (en) 2007-05-01
BR9810911A (pt) 2000-08-01
MY135057A (en) 2008-01-31
EP0991658A1 (en) 2000-04-12
US20060270606A1 (en) 2006-11-30
JP4508413B2 (ja) 2010-07-21
US8163698B2 (en) 2012-04-24
CA2296036A1 (en) 1999-01-28
AU750120B2 (en) 2002-07-11
AR018501A1 (es) 2001-11-28
NO20000231D0 (no) 2000-01-17
NO326827B1 (no) 2009-02-23
NO20000231L (no) 2000-01-17
BG104089A (en) 2000-12-29
IL133784A (en) 2005-09-25
BG65212B1 (bg) 2007-07-31
SK187999A3 (en) 2000-09-12
RU2195462C2 (ru) 2002-12-27
US7662786B2 (en) 2010-02-16
CN1264388A (zh) 2000-08-23
IL133784A0 (en) 2001-04-30
HRP980397A2 (en) 1999-04-30
JP5047935B2 (ja) 2012-10-10
US6458765B1 (en) 2002-10-01
CY1107047T1 (el) 2012-09-26
US20100099843A1 (en) 2010-04-22
JP2012211164A (ja) 2012-11-01
CO4990967A1 (es) 2000-12-26
JP5122429B2 (ja) 2013-01-16
DE69832982T2 (de) 2006-08-24
PL197884B1 (pl) 2008-05-30
CZ2000176A3 (en) 2001-06-13
DK0991658T3 (da) 2006-05-15
ATE314387T1 (de) 2006-01-15
ID24669A (id) 2000-07-27
KR20010021998A (ko) 2001-03-15
JP2009137967A (ja) 2009-06-25
NZ502296A (en) 2002-02-01
TW533217B (en) 2003-05-21
HUP0004234A2 (hu) 2001-05-28
US20030153505A1 (en) 2003-08-14
JP2001515010A (ja) 2001-09-18

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