PT991658E - Derivados de dolastatina-15 - Google Patents

Derivados de dolastatina-15

Info

Publication number
PT991658E
PT991658E PT98935531T PT98935531T PT991658E PT 991658 E PT991658 E PT 991658E PT 98935531 T PT98935531 T PT 98935531T PT 98935531 T PT98935531 T PT 98935531T PT 991658 E PT991658 E PT 991658E
Authority
PT
Portugal
Prior art keywords
dolastatin
derivatives
Prior art date
Application number
PT98935531T
Other languages
English (en)
Portuguese (pt)
Inventor
Janssen Bernd
Barlozzari Teresa
Haupt Andreas
Thomas Zierke
Andreas Kling
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of PT991658E publication Critical patent/PT991658E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT98935531T 1997-07-18 1998-07-07 Derivados de dolastatina-15 PT991658E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
PT991658E true PT991658E (pt) 2006-05-31

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98935531T PT991658E (pt) 1997-07-18 1998-07-07 Derivados de dolastatina-15

Country Status (32)

Country Link
US (6) US6143721A (OSRAM)
EP (1) EP0991658B1 (OSRAM)
JP (4) JP4508413B2 (OSRAM)
KR (1) KR100579748B1 (OSRAM)
CN (1) CN1268636C (OSRAM)
AR (1) AR018501A1 (OSRAM)
AT (1) ATE314387T1 (OSRAM)
AU (1) AU750120B2 (OSRAM)
BG (1) BG65212B1 (OSRAM)
BR (1) BR9810911A (OSRAM)
CA (1) CA2296036C (OSRAM)
CO (1) CO4990967A1 (OSRAM)
CY (1) CY1107047T1 (OSRAM)
CZ (1) CZ303045B6 (OSRAM)
DE (1) DE69832982T2 (OSRAM)
DK (1) DK0991658T3 (OSRAM)
ES (1) ES2258819T3 (OSRAM)
HR (1) HRP980397A2 (OSRAM)
HU (1) HU228996B1 (OSRAM)
ID (1) ID24669A (OSRAM)
IL (1) IL133784A (OSRAM)
MY (1) MY135057A (OSRAM)
NO (1) NO326827B1 (OSRAM)
NZ (1) NZ502296A (OSRAM)
PL (1) PL197884B1 (OSRAM)
PT (1) PT991658E (OSRAM)
RU (1) RU2195462C2 (OSRAM)
SK (1) SK286581B6 (OSRAM)
TR (2) TR200000132T2 (OSRAM)
TW (1) TW533217B (OSRAM)
WO (1) WO1999003879A1 (OSRAM)
ZA (1) ZA986358B (OSRAM)

Families Citing this family (28)

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US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686336B2 (en) 2000-02-08 2004-02-03 Federal Government As Represented By The Department Of Veterans Affaires N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
KR101208266B1 (ko) 2002-03-22 2012-12-05 에자이 알앤드디 매니지먼트 가부시키가이샤 헤미아스텔린 유도체 및 이의 용도
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
SI1545613T1 (sl) 2002-07-31 2011-11-30 Seattle Genetics Inc Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
KR101438983B1 (ko) 2003-11-06 2014-09-05 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
US20060148014A1 (en) * 2004-12-09 2006-07-06 Sergei Agoulnik Tubulin isotype screening in cancer therapy using hemiasterlin analogs
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
SG171682A1 (en) 2006-05-16 2011-06-29 Aegera Therapeutics Inc Iap bir domain binding compounds
EP2176295B1 (en) 2007-07-16 2014-11-19 Genentech, Inc. Humanized anti-cd79b antibodies and immunoconjugates and methods of use
JP5469600B2 (ja) 2007-07-16 2014-04-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
ES2643239T3 (es) 2008-01-31 2017-11-21 Genentech, Inc. Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso
CA2784748A1 (en) 2009-12-18 2011-06-23 Idenix Pharmaceuticals, Inc. 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors
CN102933231B (zh) 2010-02-10 2015-07-29 伊缪诺金公司 Cd20抗体及其用途
WO2011098904A1 (en) 2010-02-12 2011-08-18 Aegera Therapeutics, Inc. Iap bir domain binding compounds
EP2922818B1 (en) 2012-11-24 2018-09-05 Hangzhou Dac Biotech Co., Ltd Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
EP3262071B8 (en) 2014-09-23 2022-05-18 F. Hoffmann-La Roche AG Method of using anti-cd79b immunoconjugates
CN108026123B (zh) 2015-06-15 2021-02-05 杭州多禧生物科技有限公司 用于偶联的亲水链接体
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR102345175B1 (ko) 2016-11-14 2021-12-31 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
AU2022338463A1 (en) 2021-09-03 2024-03-21 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
AU2021362997A1 (en) 2021-11-03 2024-05-16 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DE69230824T2 (de) * 1991-08-09 2000-07-27 Teikoku Hormone Mfg. Co., Ltd. Neue tetrapeptidderivate
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
WO1993017388A1 (en) 1992-02-26 1993-09-02 Clark Paul C System for protecting computers via intelligent tokens or smart cards
DK0642530T3 (da) * 1992-05-20 1998-10-26 Basf Ag Dolastatinderivater
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
ATE196296T1 (de) * 1992-12-16 2000-09-15 Basf Ag Dolastatin analog
US5554993A (en) 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
WO1998030297A1 (en) 1997-01-10 1998-07-16 Silicon Gaming, Inc. Method and apparatus for providing authenticated, secure on-line communication between remote locations
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
US7084110B2 (en) 2006-08-01
IL133784A (en) 2005-09-25
EP0991658A1 (en) 2000-04-12
US20100099843A1 (en) 2010-04-22
US20130046077A1 (en) 2013-02-21
JP2012211164A (ja) 2012-11-01
NO20000231L (no) 2000-01-17
CA2296036A1 (en) 1999-01-28
ID24669A (id) 2000-07-27
JP5047935B2 (ja) 2012-10-10
AU8475898A (en) 1999-02-10
CY1107047T1 (el) 2012-09-26
ATE314387T1 (de) 2006-01-15
EP0991658B1 (en) 2005-12-28
WO1999003879A1 (en) 1999-01-28
DE69832982T2 (de) 2006-08-24
HK1029125A1 (en) 2001-03-23
AR018501A1 (es) 2001-11-28
CZ303045B6 (cs) 2012-03-07
SK187999A3 (en) 2000-09-12
CN1268636C (zh) 2006-08-09
DE69832982D1 (de) 2006-02-02
ES2258819T3 (es) 2006-09-01
HRP980397A2 (en) 1999-04-30
CO4990967A1 (es) 2000-12-26
NO20000231D0 (no) 2000-01-17
KR20010021998A (ko) 2001-03-15
JP2009137968A (ja) 2009-06-25
BG104089A (en) 2000-12-29
CZ2000176A3 (en) 2001-06-13
IL133784A0 (en) 2001-04-30
US20060270606A1 (en) 2006-11-30
BG65212B1 (bg) 2007-07-31
US20030153505A1 (en) 2003-08-14
TR200103545T2 (tr) 2002-06-21
KR100579748B1 (ko) 2006-05-15
DK0991658T3 (da) 2006-05-15
US6458765B1 (en) 2002-10-01
RU2195462C2 (ru) 2002-12-27
JP4508413B2 (ja) 2010-07-21
SK286581B6 (sk) 2009-01-07
JP2001515010A (ja) 2001-09-18
CN1264388A (zh) 2000-08-23
CA2296036C (en) 2007-05-01
BR9810911A (pt) 2000-08-01
HUP0004234A3 (en) 2001-08-28
NO326827B1 (no) 2009-02-23
AU750120B2 (en) 2002-07-11
ZA986358B (en) 2000-01-17
US8163698B2 (en) 2012-04-24
US7662786B2 (en) 2010-02-16
MY135057A (en) 2008-01-31
PL338144A1 (en) 2000-09-25
TW533217B (en) 2003-05-21
HUP0004234A2 (hu) 2001-05-28
HU228996B1 (hu) 2013-07-29
TR200000132T2 (tr) 2000-05-22
PL197884B1 (pl) 2008-05-30
JP5122429B2 (ja) 2013-01-16
US6143721A (en) 2000-11-07
JP2009137967A (ja) 2009-06-25
NZ502296A (en) 2002-02-01

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