TR200000033T2 - Oksimorfon, oksikodon ve türevlerinin hazırlanması - Google Patents

Oksimorfon, oksikodon ve türevlerinin hazırlanması

Info

Publication number
TR200000033T2
TR200000033T2 TR2000/00033T TR200000033T TR200000033T2 TR 200000033 T2 TR200000033 T2 TR 200000033T2 TR 2000/00033 T TR2000/00033 T TR 2000/00033T TR 200000033 T TR200000033 T TR 200000033T TR 200000033 T2 TR200000033 T2 TR 200000033T2
Authority
TR
Turkey
Prior art keywords
derivatives
oxymorphone
oxycodone
preparation
noroxymorphone
Prior art date
Application number
TR2000/00033T
Other languages
English (en)
Turkish (tr)
Inventor
Huang Bao-Shan
Christodoulou Aris
Lu Yansong
Ji Ben-Yi
Original Assignee
Penick Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200000033(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corporation filed Critical Penick Corporation
Publication of TR200000033T2 publication Critical patent/TR200000033T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
TR2000/00033T 1997-07-11 1998-07-10 Oksimorfon, oksikodon ve türevlerinin hazırlanması TR200000033T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates

Publications (1)

Publication Number Publication Date
TR200000033T2 true TR200000033T2 (tr) 2000-12-21

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00033T TR200000033T2 (tr) 1997-07-11 1998-07-10 Oksimorfon, oksikodon ve türevlerinin hazırlanması

Country Status (19)

Country Link
US (7) US5869669A (en:Method)
EP (1) EP1000065B1 (en:Method)
JP (1) JP2001518444A (en:Method)
KR (1) KR100363486B1 (en:Method)
CN (1) CN1152880C (en:Method)
AT (1) ATE291023T1 (en:Method)
AU (1) AU740822B2 (en:Method)
CA (1) CA2296035C (en:Method)
DE (1) DE69829379D1 (en:Method)
HU (1) HUP0003918A3 (en:Method)
IL (1) IL133792A0 (en:Method)
IN (1) IN1998KO01500A (en:Method)
NO (1) NO20000111L (en:Method)
RU (1) RU2183636C2 (en:Method)
SK (1) SK102000A3 (en:Method)
TR (1) TR200000033T2 (en:Method)
TW (1) TW505648B (en:Method)
WO (1) WO1999002529A1 (en:Method)
ZA (1) ZA986144B (en:Method)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912347A (en) * 1996-09-30 1999-06-15 Mallinckrodt Inc. Process for preparing a morphinan derivative
WO2000066588A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services Direct c-14 oxidation of opioids
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
HUP0401600A3 (en) * 2001-08-23 2008-05-28 Organon Nv Process for the preparation of 14-hydroxymorphine derivatives
JP3961796B2 (ja) * 2001-08-27 2007-08-22 ソニー株式会社 情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
RU2236412C2 (ru) * 2002-07-18 2004-09-20 Власов Михаил Иванович Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
EP1562953B1 (en) * 2002-11-08 2009-09-30 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
CA2507522C (en) 2002-12-13 2015-02-24 Durect Corporation Oral drug delivery system
US6864370B1 (en) * 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
US6790959B1 (en) 2003-06-05 2004-09-14 Halsey Drug Company, Inc. Process for manufacturing thebaine
US7875718B2 (en) * 2003-09-22 2011-01-25 Johnson Matthey Public Limited Company Process for the synthesis of morphinane compounds and intermediates thereof
JP4879740B2 (ja) 2003-09-22 2012-02-22 ジョンソン、マッセイ、パブリック、リミテッド、カンパニー モルヒナン化合物およびその中間体の合成法
EP2194059A3 (en) 2004-02-06 2010-09-22 Euro-Celtique S.A. Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
EP1758908A1 (en) * 2004-06-08 2007-03-07 Mallinckrodt, Inc. Extraction of alkaloids from opium
WO2005123039A1 (en) 2004-06-12 2005-12-29 Collegium Pharmaceutical, Inc. Abuse-deterrent drug formulations
EP2767292B1 (en) 2004-09-17 2016-08-24 Durect Corporation Sustained Local Anesthetic Composition Containing SAIB
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
GB0421687D0 (en) * 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
HRP20090387T1 (hr) * 2005-03-04 2009-08-31 Euro-Celtique S.A. Postupak reduciranja alfa, beta nezasićenih ketona u opioidnim sastavima
EP1873158B1 (en) * 2005-04-06 2016-04-06 Toray Industries, Inc. Crystals of morphinan derivative and process for producing the same
US8071768B2 (en) * 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
JP2008546688A (ja) * 2005-06-16 2008-12-25 マリンクロッド・インコーポレイテッド １−ハロ−テバインまたは類似体を介する１４−ヒドロキシルオピエート類への合成経路
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
DE602007003197D1 (de) 2006-03-02 2009-12-24 Mallinckrodt Inc Verfahren zur herstellung von morphinan-6-on-produkten mit geringen konzentrationen von alpha-, beta-ungesättigten ketonverbindungen
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
JP2010504325A (ja) * 2006-09-20 2010-02-12 マリンクロット インコーポレイテッド 置換モルフィナン−６−オン、並びにその塩および中間体の調製
EP2073636B1 (en) 2006-10-17 2012-09-05 Penick Corporation Process for preparing oxymorphone
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
CA2671518C (en) * 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
ES2378710T3 (es) * 2006-12-04 2012-04-17 Noramco, Inc. Procedimiento para reducir impurezas en la base de oxicodona
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
JP2010522189A (ja) * 2007-03-23 2010-07-01 マリンクロッド・インコーポレイテッド オリパビンからのオキシモルホンの改善された調製
JP5373764B2 (ja) * 2007-04-16 2013-12-18 マリンクロッド エルエルシー 触媒性水素転移反応を使用する新規なオピエート還元
WO2008144320A2 (en) * 2007-05-17 2008-11-27 Endo Pharmaceuticals, Inc. Opioid and methods of making and using the same
EP2219622A1 (en) 2007-12-06 2010-08-25 Durect Corporation Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
US8461337B2 (en) 2007-12-17 2013-06-11 Mallinckrodt Llc Sinomenine derivatives and processes for their synthesis
ES2569655T3 (es) 2007-12-17 2016-05-12 Mallinckrodt Llc Procedimientos para la producción de compuestos de (+)-'nal' morfinano
WO2009111162A1 (en) 2008-02-29 2009-09-11 Mallinckrodt Inc. Process for the preparation of 3-hydroxymorphinan derivatives
US8440686B2 (en) * 2008-04-24 2013-05-14 Janssen Pharmaceutica Nv Nalmefene prodrugs
PL2285780T3 (pl) * 2008-05-27 2016-02-29 SpecGx LLC Sposoby i związki do wytwarzania normorfinanów
EP2331508B1 (en) 2008-09-03 2014-11-12 Mallinckrodt LLC Substituted berbines and processes for their synthesis
US8080661B2 (en) * 2008-09-30 2011-12-20 Mallinckrodt Llc Processes for the synthesis of tertiary amines
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
ES2666404T3 (es) 2010-06-11 2018-05-04 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
US8703950B2 (en) 2010-07-02 2014-04-22 Johnson Matthey Public Limited Co. Low ABUK oxycodone, its salts and methods of making same
RU2448709C1 (ru) * 2011-02-01 2012-04-27 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения налтрексона
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
JP6141444B2 (ja) 2012-12-14 2017-06-07 パーデュー、ファーマ、リミテッド、パートナーシップ スピロ環式モルフィナンおよびこれらの使用
EP2931725B1 (en) 2012-12-14 2017-02-15 Purdue Pharma LP Nitrogen containing morphinan derivatives and the use thereof
TWI513697B (zh) 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
TW201441199A (zh) 2012-12-28 2014-11-01 Purdue Pharma Lp 經取代之嗎啡喃類及其用途
JP6159416B2 (ja) 2012-12-28 2017-07-05 パーデュー、ファーマ、リミテッド、パートナーシップ ７，８−環式モルフィナン類似体
MX2015008624A (es) 2012-12-31 2016-12-08 Rhodes Tech PROCESO PARA PREPARAR 6A, 14A-ETENOMORFINANOS 7ß SUSTITUIDOS Y 6A, 14A-ETANOMORFINANOS 7ß-SUSTITUIDOS.
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
EP2829541A1 (en) * 2013-07-26 2015-01-28 Siegfried AG Novel synthesis of noroxymorphone from morphine
US9120800B2 (en) 2013-08-02 2015-09-01 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone alkaloid and oxymorphone salts
US9988392B2 (en) 2013-12-26 2018-06-05 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
EP3087079B1 (en) 2013-12-26 2019-04-03 Purdue Pharma LP Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
US9902726B2 (en) 2013-12-30 2018-02-27 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
BR112017011069A2 (pt) 2014-11-25 2018-07-10 Kempharm Inc ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
SG11201811760VA (en) 2016-07-06 2019-01-30 Durect Corp Oral dosage form with drug composition, barrier layer and drug layer
LT3559010T (lt) 2016-12-23 2022-10-10 Minoryx Therapeutics S.L. 5-[[4-[2-[5-(1-hidroksietil)-2-piridinil]etoksi]fenil]metil]-2,4-tiazolidindiono ir jo druskų gavimo būdas
SK592017A3 (sk) 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
WO2019165298A1 (en) 2018-02-23 2019-08-29 Rhodes Technologies Novel opioid compounds and uses thereof
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
US11613547B2 (en) 2019-07-08 2023-03-28 University Of Health Sciences & Pharmacy In St. Louis G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
CN114621239A (zh) * 2020-12-10 2022-06-14 鲁南制药集团股份有限公司 一种纳曲酮的制备方法
WO2022144911A1 (en) * 2020-12-28 2022-07-07 Navin Saxena Research & Technology Pvt. Ltd. Novel process for the synthesis of noroxymorphone from morphine
EP4277702A1 (en) 2021-01-12 2023-11-22 Durect Corporation Sustained release drug delivery systems and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819636A (en) * 1970-09-15 1974-06-25 American Home Prod 4a,10-(methaniminomethano)phenanthrene derivatives
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4639520A (en) * 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
FR2562072B1 (fr) * 1984-03-27 1989-07-07 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives

Also Published As

Publication number Publication date
AU740822B2 (en) 2001-11-15
US5952495A (en) 1999-09-14
CA2296035A1 (en) 1999-01-21
CA2296035C (en) 2004-04-13
JP2001518444A (ja) 2001-10-16
TW505648B (en) 2002-10-11
NO20000111L (no) 2000-02-25
HK1028025A1 (en) 2001-02-02
US6013796A (en) 2000-01-11
CN1272845A (zh) 2000-11-08
EP1000065A4 (en) 2001-09-12
ZA986144B (en) 1999-05-19
DE69829379D1 (de) 2005-04-21
CN1152880C (zh) 2004-06-09
EP1000065B1 (en) 2005-03-16
IL133792A0 (en) 2001-04-30
US6008354A (en) 1999-12-28
EP1000065A1 (en) 2000-05-17
US5948788A (en) 1999-09-07
US5869669A (en) 1999-02-09
US5922876A (en) 1999-07-13
IN1998KO01500A (en:Method) 2005-03-11
HUP0003918A3 (en) 2003-04-28
HUP0003918A2 (hu) 2001-07-30
AU8379198A (en) 1999-02-08
KR100363486B1 (ko) 2002-12-16
ATE291023T1 (de) 2005-04-15
NO20000111D0 (no) 2000-01-10
US6008355A (en) 1999-12-28
KR20010021693A (ko) 2001-03-15
RU2183636C2 (ru) 2002-06-20
WO1999002529A1 (en) 1999-01-21
SK102000A3 (en) 2000-07-11

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