|
US5912347A
(en)
*
|
1996-09-30 |
1999-06-15 |
Mallinckrodt Inc. |
Process for preparing a morphinan derivative
|
|
WO2000066588A1
(en)
*
|
1999-05-05 |
2000-11-09 |
The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services |
Direct c-14 oxidation of opioids
|
|
US6177567B1
(en)
|
1999-10-15 |
2001-01-23 |
Boehringer Ingelheim Chemicals, Inc. |
Method for preparing oxycodone
|
|
HUP0401600A3
(en)
*
|
2001-08-23 |
2008-05-28 |
Organon Nv |
Process for the preparation of 14-hydroxymorphine derivatives
|
|
JP3961796B2
(ja)
*
|
2001-08-27 |
2007-08-22 |
ソニー株式会社 |
情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
|
|
DE10161963A1
(de)
*
|
2001-12-17 |
2003-07-03 |
Johannes Schuetz |
6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
|
|
US20040001889A1
(en)
|
2002-06-25 |
2004-01-01 |
Guohua Chen |
Short duration depot formulations
|
|
US20040058946A1
(en)
*
|
2002-07-05 |
2004-03-25 |
Buchwald Stephen L. |
Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
|
|
RU2236412C2
(ru)
*
|
2002-07-18 |
2004-09-20 |
Власов Михаил Иванович |
Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
|
|
RU2215741C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
|
|
RU2215742C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
|
|
EP1562953B1
(en)
*
|
2002-11-08 |
2009-09-30 |
Mallinckrodt Inc. |
Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
|
|
CA2507522C
(en)
|
2002-12-13 |
2015-02-24 |
Durect Corporation |
Oral drug delivery system
|
|
US6864370B1
(en)
*
|
2003-06-05 |
2005-03-08 |
Zhaiwei Lin |
Process for manufacturing oxycodone
|
|
US6790959B1
(en)
|
2003-06-05 |
2004-09-14 |
Halsey Drug Company, Inc. |
Process for manufacturing thebaine
|
|
US7875718B2
(en)
*
|
2003-09-22 |
2011-01-25 |
Johnson Matthey Public Limited Company |
Process for the synthesis of morphinane compounds and intermediates thereof
|
|
JP4879740B2
(ja)
|
2003-09-22 |
2012-02-22 |
ジョンソン、マッセイ、パブリック、リミテッド、カンパニー |
モルヒナン化合物およびその中間体の合成法
|
|
EP2194059A3
(en)
|
2004-02-06 |
2010-09-22 |
Euro-Celtique S.A. |
Methods for making 3-O-protected morphinones and 3-O-protected morphinone dienol carboxylates
|
|
TWI365880B
(en)
|
2004-03-30 |
2012-06-11 |
Euro Celtique Sa |
Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
|
|
SK286047B6
(sk)
*
|
2004-04-13 |
2008-01-07 |
Zentiva, A. S. |
Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
|
|
US6946556B1
(en)
*
|
2004-05-21 |
2005-09-20 |
Acura Pharmaceuticals, Inc. |
Preparation of opioid analgesics by a one-pot process
|
|
EP1758908A1
(en)
*
|
2004-06-08 |
2007-03-07 |
Mallinckrodt, Inc. |
Extraction of alkaloids from opium
|
|
WO2005123039A1
(en)
|
2004-06-12 |
2005-12-29 |
Collegium Pharmaceutical, Inc. |
Abuse-deterrent drug formulations
|
|
EP2767292B1
(en)
|
2004-09-17 |
2016-08-24 |
Durect Corporation |
Sustained Local Anesthetic Composition Containing SAIB
|
|
GB0421149D0
(en)
*
|
2004-09-23 |
2004-10-27 |
Johnson Matthey Plc |
Preparation of oxycodone
|
|
GB0421687D0
(en)
*
|
2004-09-30 |
2004-11-03 |
Johnson Matthey Plc |
Preparation of opiate analgesics
|
|
WO2006084389A1
(de)
*
|
2005-02-11 |
2006-08-17 |
Cilag Ltd. |
Verfahren zur reinigung von noroxymorphon-verbindungen
|
|
HRP20090387T1
(hr)
*
|
2005-03-04 |
2009-08-31 |
Euro-Celtique S.A. |
Postupak reduciranja alfa, beta nezasićenih ketona u opioidnim sastavima
|
|
EP1873158B1
(en)
*
|
2005-04-06 |
2016-04-06 |
Toray Industries, Inc. |
Crystals of morphinan derivative and process for producing the same
|
|
US8071768B2
(en)
*
|
2005-06-10 |
2011-12-06 |
Janssen Pharmaceutica, N.V. |
Alkylquinoline and alkylquinazoline kinase modulators
|
|
JP2008546688A
(ja)
*
|
2005-06-16 |
2008-12-25 |
マリンクロッド・インコーポレイテッド |
１−ハロ−テバインまたは類似体を介する１４−ヒドロキシルオピエート類への合成経路
|
|
US20070027105A1
(en)
|
2005-07-26 |
2007-02-01 |
Alza Corporation |
Peroxide removal from drug delivery vehicle
|
|
US20070117826A1
(en)
*
|
2005-11-23 |
2007-05-24 |
Forest Laboratories, Inc. |
Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
|
|
DE602007003197D1
(de)
|
2006-03-02 |
2009-12-24 |
Mallinckrodt Inc |
Verfahren zur herstellung von morphinan-6-on-produkten mit geringen konzentrationen von alpha-, beta-ungesättigten ketonverbindungen
|
|
SA07280459B1
(ar)
|
2006-08-25 |
2011-07-20 |
بيورديو فارما إل. بي. |
أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
|
|
JP2010504325A
(ja)
*
|
2006-09-20 |
2010-02-12 |
マリンクロット インコーポレイテッド |
置換モルフィナン−６−オン、並びにその塩および中間体の調製
|
|
EP2073636B1
(en)
|
2006-10-17 |
2012-09-05 |
Penick Corporation |
Process for preparing oxymorphone
|
|
CA2674915C
(en)
*
|
2006-10-17 |
2015-06-30 |
Penick Corporation |
Process for preparing oxymorphone
|
|
AU2012216358B2
(en)
*
|
2006-10-17 |
2014-11-20 |
Penick Corporation |
Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
|
|
US20080125592A1
(en)
*
|
2006-10-17 |
2008-05-29 |
Penick Corporation |
Process for preparing oxymorphone, naltrexone, and buprenorphine
|
|
AU2007325918B2
(en)
|
2006-11-03 |
2013-10-17 |
Durect Corporation |
Transdermal delivery systems comprising bupivacaine
|
|
CA2671518C
(en)
*
|
2006-12-04 |
2016-06-07 |
Noramco, Inc. |
Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
|
|
ES2378710T3
(es)
*
|
2006-12-04 |
2012-04-17 |
Noramco, Inc. |
Procedimiento para reducir impurezas en la base de oxicodona
|
|
GB0624880D0
(en)
*
|
2006-12-14 |
2007-01-24 |
Johnson Matthey Plc |
Improved method for making analgesics
|
|
PL2137189T3
(pl)
*
|
2007-03-06 |
2015-12-31 |
SpecGx LLC |
Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
|
|
US9040726B2
(en)
*
|
2007-03-06 |
2015-05-26 |
Mallinckrodt Llc |
Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
|
|
JP2010522189A
(ja)
*
|
2007-03-23 |
2010-07-01 |
マリンクロッド・インコーポレイテッド |
オリパビンからのオキシモルホンの改善された調製
|
|
JP5373764B2
(ja)
*
|
2007-04-16 |
2013-12-18 |
マリンクロッド エルエルシー |
触媒性水素転移反応を使用する新規なオピエート還元
|
|
WO2008144320A2
(en)
*
|
2007-05-17 |
2008-11-27 |
Endo Pharmaceuticals, Inc. |
Opioid and methods of making and using the same
|
|
EP2219622A1
(en)
|
2007-12-06 |
2010-08-25 |
Durect Corporation |
Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
|
|
US8461337B2
(en)
|
2007-12-17 |
2013-06-11 |
Mallinckrodt Llc |
Sinomenine derivatives and processes for their synthesis
|
|
ES2569655T3
(es)
|
2007-12-17 |
2016-05-12 |
Mallinckrodt Llc |
Procedimientos para la producción de compuestos de (+)-'nal' morfinano
|
|
WO2009111162A1
(en)
|
2008-02-29 |
2009-09-11 |
Mallinckrodt Inc. |
Process for the preparation of 3-hydroxymorphinan derivatives
|
|
US8440686B2
(en)
*
|
2008-04-24 |
2013-05-14 |
Janssen Pharmaceutica Nv |
Nalmefene prodrugs
|
|
PL2285780T3
(pl)
*
|
2008-05-27 |
2016-02-29 |
SpecGx LLC |
Sposoby i związki do wytwarzania normorfinanów
|
|
EP2331508B1
(en)
|
2008-09-03 |
2014-11-12 |
Mallinckrodt LLC |
Substituted berbines and processes for their synthesis
|
|
US8080661B2
(en)
*
|
2008-09-30 |
2011-12-20 |
Mallinckrodt Llc |
Processes for the synthesis of tertiary amines
|
|
US20100260844A1
(en)
|
2008-11-03 |
2010-10-14 |
Scicinski Jan J |
Oral pharmaceutical dosage forms
|
|
UA102916C2
(uk)
|
2009-07-02 |
2013-08-27 |
Кемфарм, Інк. |
Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
|
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
|
ES2666404T3
(es)
|
2010-06-11 |
2018-05-04 |
Rhodes Technologies |
Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
|
|
EP2580218B1
(en)
|
2010-06-11 |
2015-02-25 |
Rhodes Technologies |
Process for n-dealkylation of tertiary amines
|
|
US8703950B2
(en)
|
2010-07-02 |
2014-04-22 |
Johnson Matthey Public Limited Co. |
Low ABUK oxycodone, its salts and methods of making same
|
|
RU2448709C1
(ru)
*
|
2011-02-01 |
2012-04-27 |
Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) |
Способ получения налтрексона
|
|
TWI560170B
(en)
*
|
2011-12-06 |
2016-12-01 |
Lundbeck & Co As H |
Process for recovery of nalmefene hydrochloride
|
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
|
JP6141444B2
(ja)
|
2012-12-14 |
2017-06-07 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
スピロ環式モルフィナンおよびこれらの使用
|
|
EP2931725B1
(en)
|
2012-12-14 |
2017-02-15 |
Purdue Pharma LP |
Nitrogen containing morphinan derivatives and the use thereof
|
|
TWI513697B
(zh)
|
2012-12-14 |
2015-12-21 |
Purdue Pharma Lp |
吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
|
|
TW201441199A
(zh)
|
2012-12-28 |
2014-11-01 |
Purdue Pharma Lp |
經取代之嗎啡喃類及其用途
|
|
JP6159416B2
(ja)
|
2012-12-28 |
2017-07-05 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
７，８−環式モルフィナン類似体
|
|
MX2015008624A
(es)
|
2012-12-31 |
2016-12-08 |
Rhodes Tech |
PROCESO PARA PREPARAR 6A, 14A-ETENOMORFINANOS 7ß SUSTITUIDOS Y 6A, 14A-ETANOMORFINANOS 7ß-SUSTITUIDOS.
|
|
US9555113B2
(en)
|
2013-03-15 |
2017-01-31 |
Durect Corporation |
Compositions with a rheological modifier to reduce dissolution variability
|
|
EP2829541A1
(en)
*
|
2013-07-26 |
2015-01-28 |
Siegfried AG |
Novel synthesis of noroxymorphone from morphine
|
|
US9120800B2
(en)
|
2013-08-02 |
2015-09-01 |
Johnson Matthey Public Limited Company |
Process for the preparation of oxymorphone alkaloid and oxymorphone salts
|
|
US9988392B2
(en)
|
2013-12-26 |
2018-06-05 |
Purdue Pharma L.P. |
7-beta-alkyl analogs of orvinols
|
|
EP3087079B1
(en)
|
2013-12-26 |
2019-04-03 |
Purdue Pharma LP |
Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
|
|
US9340542B2
(en)
|
2013-12-26 |
2016-05-17 |
Purdue Pharma L.P. |
Propellane-based compounds and the use thereof
|
|
WO2015097547A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
10-substituted morphinan hydantoins
|
|
US9902726B2
(en)
|
2013-12-30 |
2018-02-27 |
Purdue Pharma L.P. |
Pyridone-sulfone morphinan analogs as opioid receptor ligands
|
|
BR112017011069A2
(pt)
|
2014-11-25 |
2018-07-10 |
Kempharm Inc |
ácido benzóico, derivados e ácido benzóico e conjugados de ácido heteroaril carboxílico de oxicodona
|
|
EP3252055B1
(en)
|
2016-05-31 |
2018-09-19 |
Alcaliber Investigacion Desarrollo e Innovacion SLU |
Process for obtaining 3,14-diacetyloxymorphone from oripavine
|
|
US9737530B1
(en)
|
2016-06-23 |
2017-08-22 |
Collegium Pharmaceutical, Inc. |
Process of making stable abuse-deterrent oral formulations
|
|
SG11201811760VA
(en)
|
2016-07-06 |
2019-01-30 |
Durect Corp |
Oral dosage form with drug composition, barrier layer and drug layer
|
|
LT3559010T
(lt)
|
2016-12-23 |
2022-10-10 |
Minoryx Therapeutics S.L. |
5-[[4-[2-[5-(1-hidroksietil)-2-piridinil]etoksi]fenil]metil]-2,4-tiazolidindiono ir jo druskų gavimo būdas
|
|
SK592017A3
(sk)
|
2017-07-04 |
2019-01-08 |
Saneca Pharmaceuticals A. S. |
Spôsob prípravy morfínanových zlúčenín
|
|
WO2019165298A1
(en)
|
2018-02-23 |
2019-08-29 |
Rhodes Technologies |
Novel opioid compounds and uses thereof
|
|
CN110054656B
(zh)
*
|
2019-05-28 |
2021-02-02 |
宜昌人福药业有限责任公司 |
一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
|
|
US11613547B2
(en)
|
2019-07-08 |
2023-03-28 |
University Of Health Sciences & Pharmacy In St. Louis |
G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
|
|
KR20220140711A
(ko)
|
2020-01-13 |
2022-10-18 |
듀렉트 코퍼레이션 |
불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
|
|
CN114621239A
(zh)
*
|
2020-12-10 |
2022-06-14 |
鲁南制药集团股份有限公司 |
一种纳曲酮的制备方法
|
|
WO2022144911A1
(en)
*
|
2020-12-28 |
2022-07-07 |
Navin Saxena Research & Technology Pvt. Ltd. |
Novel process for the synthesis of noroxymorphone from morphine
|
|
EP4277702A1
(en)
|
2021-01-12 |
2023-11-22 |
Durect Corporation |
Sustained release drug delivery systems and related methods
|