ZA986144B - Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones - Google Patents

Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Info

Publication number
ZA986144B
ZA986144B ZA986144A ZA986144A ZA986144B ZA 986144 B ZA986144 B ZA 986144B ZA 986144 A ZA986144 A ZA 986144A ZA 986144 A ZA986144 A ZA 986144A ZA 986144 B ZA986144 B ZA 986144B
Authority
ZA
South Africa
Prior art keywords
noroxymorphone
naltrexone
hydroxynormorphinones
normorphinones
oxymorphone
Prior art date
Application number
ZA986144A
Other languages
English (en)
Inventor
Bao-Shan Huang
Yansong Lu
Ben-Yi Ji
Aris Christodoulou
Original Assignee
Penick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA986144(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corp filed Critical Penick Corp
Priority to ZA986144A priority Critical patent/ZA986144B/xx
Publication of ZA986144B publication Critical patent/ZA986144B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA986144A 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones ZA986144B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ZA986144A ZA986144B (en) 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ZA986144A ZA986144B (en) 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Publications (1)

Publication Number Publication Date
ZA986144B true ZA986144B (en) 1999-05-19

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA986144A ZA986144B (en) 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Country Status (19)

Country Link
US (7) US5869669A (en:Method)
EP (1) EP1000065B1 (en:Method)
JP (1) JP2001518444A (en:Method)
KR (1) KR100363486B1 (en:Method)
CN (1) CN1152880C (en:Method)
AT (1) ATE291023T1 (en:Method)
AU (1) AU740822B2 (en:Method)
CA (1) CA2296035C (en:Method)
DE (1) DE69829379D1 (en:Method)
HU (1) HUP0003918A3 (en:Method)
IL (1) IL133792A0 (en:Method)
IN (1) IN1998KO01500A (en:Method)
NO (1) NO20000111L (en:Method)
RU (1) RU2183636C2 (en:Method)
SK (1) SK102000A3 (en:Method)
TR (1) TR200000033T2 (en:Method)
TW (1) TW505648B (en:Method)
WO (1) WO1999002529A1 (en:Method)
ZA (1) ZA986144B (en:Method)

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RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
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Also Published As

Publication number Publication date
CN1152880C (zh) 2004-06-09
US6008355A (en) 1999-12-28
IN1998KO01500A (en:Method) 2005-03-11
US5948788A (en) 1999-09-07
RU2183636C2 (ru) 2002-06-20
NO20000111D0 (no) 2000-01-10
US6013796A (en) 2000-01-11
SK102000A3 (en) 2000-07-11
AU8379198A (en) 1999-02-08
JP2001518444A (ja) 2001-10-16
US6008354A (en) 1999-12-28
US5922876A (en) 1999-07-13
ATE291023T1 (de) 2005-04-15
CN1272845A (zh) 2000-11-08
CA2296035A1 (en) 1999-01-21
EP1000065A4 (en) 2001-09-12
KR20010021693A (ko) 2001-03-15
HUP0003918A3 (en) 2003-04-28
TW505648B (en) 2002-10-11
US5952495A (en) 1999-09-14
TR200000033T2 (tr) 2000-12-21
US5869669A (en) 1999-02-09
IL133792A0 (en) 2001-04-30
NO20000111L (no) 2000-02-25
WO1999002529A1 (en) 1999-01-21
HUP0003918A2 (hu) 2001-07-30
DE69829379D1 (de) 2005-04-21
EP1000065A1 (en) 2000-05-17
CA2296035C (en) 2004-04-13
EP1000065B1 (en) 2005-03-16
AU740822B2 (en) 2001-11-15
KR100363486B1 (ko) 2002-12-16
HK1028025A1 (en) 2001-02-02

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