TR199900920T2 - Nafthiridin türevleri. - Google Patents
Nafthiridin türevleri.Info
- Publication number
- TR199900920T2 TR199900920T2 TR1999/00920T TR9900920T TR199900920T2 TR 199900920 T2 TR199900920 T2 TR 199900920T2 TR 1999/00920 T TR1999/00920 T TR 1999/00920T TR 9900920 T TR9900920 T TR 9900920T TR 199900920 T2 TR199900920 T2 TR 199900920T2
- Authority
- TR
- Turkey
- Prior art keywords
- processes
- revleri
- naphthiridin
- compounds
- asylum
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Serbest veya tuz formunda olan yeni 8-aril-1,7-nafthiridinler PDE IV inhibitörleri olup bu nedenle örnegin aslim terapisi için farmakolojik olarak kullanislidirlar. Tercih edilen bilesikler içindeki R gruplari tanimlandigi gibi olan formül I ve II'nin bilesiklerini kapsar. Bilesikleri içeren farmakolojik kompozisyonlar bilesiklerin hazirlanmasi için olan islemler ve bu islemlerde kullanilacak olan ara islemler eklenmistir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9622386.2A GB9622386D0 (en) | 1996-10-28 | 1996-10-28 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
TR199900920T2 true TR199900920T2 (tr) | 1999-06-21 |
Family
ID=10802050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR1999/00920T TR199900920T2 (tr) | 1996-10-28 | 1997-10-24 | Nafthiridin türevleri. |
Country Status (32)
Country | Link |
---|---|
US (1) | US6136821A (tr) |
EP (1) | EP0934320B1 (tr) |
JP (1) | JP4451496B2 (tr) |
KR (1) | KR100524329B1 (tr) |
CN (1) | CN1103773C (tr) |
AR (1) | AR009128A1 (tr) |
AT (1) | ATE236155T1 (tr) |
AU (1) | AU724471B2 (tr) |
BR (1) | BR9713280B1 (tr) |
CA (1) | CA2269946C (tr) |
CO (1) | CO4910164A1 (tr) |
CZ (1) | CZ146699A3 (tr) |
DE (1) | DE69720493T2 (tr) |
DK (1) | DK0934320T3 (tr) |
ES (1) | ES2196377T3 (tr) |
GB (1) | GB9622386D0 (tr) |
HK (1) | HK1022305A1 (tr) |
HU (1) | HUP9904204A3 (tr) |
ID (1) | ID18623A (tr) |
IL (2) | IL129502A0 (tr) |
MY (1) | MY132642A (tr) |
NO (1) | NO312677B1 (tr) |
NZ (1) | NZ335363A (tr) |
PE (1) | PE10899A1 (tr) |
PL (1) | PL189280B1 (tr) |
PT (1) | PT934320E (tr) |
SI (1) | SI0934320T1 (tr) |
SK (1) | SK283562B6 (tr) |
TR (1) | TR199900920T2 (tr) |
TW (1) | TW399052B (tr) |
WO (1) | WO1998018796A1 (tr) |
ZA (1) | ZA979593B (tr) |
Families Citing this family (96)
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AU2107700A (en) | 1999-01-15 | 2000-08-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides with pde-iv inhibiting activity |
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US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
PL364910A1 (en) | 2001-01-31 | 2004-12-27 | Pfizer Products Inc. | Ether derivatives useful as inhibitors of pde4 isozymes |
IL156413A0 (en) | 2001-01-31 | 2004-01-04 | Pfizer Prod Inc | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
EE200300362A (et) | 2001-01-31 | 2003-12-15 | Pfizer Products Inc. | PDE4 isosüümide inhibiitoritena kasutatavad tiasolüül-, oksasolüül-, pürrolüül- ja imidasolüülhappeamiidi derivaadid |
JP4510383B2 (ja) * | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 軟骨疾患修復治療用組成物 |
NZ532288A (en) * | 2001-10-16 | 2005-12-23 | Memory Pharm Corp | 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as PDE-4 inhibitors for the treatment of neurological syndromes |
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US7087625B2 (en) | 2002-11-19 | 2006-08-08 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
GB0229281D0 (en) * | 2002-12-16 | 2003-01-22 | Novartis Ag | Organic compounds |
JP2006523710A (ja) * | 2003-04-16 | 2006-10-19 | メモリー・ファーマシューティカルズ・コーポレイション | ホスホジエステラーゼ4インヒビター |
RU2379292C2 (ru) * | 2003-04-18 | 2010-01-20 | Мемори Фармасьютиклз Корпорейшн | Производные пиразола в качестве ингибиторов фосфодиэстеразы 4 |
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MY141255A (en) | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
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US20050282818A1 (en) * | 2004-06-22 | 2005-12-22 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
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EP1799673A1 (en) * | 2004-10-15 | 2007-06-27 | Memory Pharmaceuticals Corporation | Pyrazole derivatives as phosphodiesterase 4 inhibitors |
CN101166737A (zh) * | 2004-10-20 | 2008-04-23 | 记忆药物公司 | 磷酸二酯酶4抑制剂 |
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EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
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JPS54138572A (en) * | 1978-04-17 | 1979-10-27 | Kyowa Hakko Kogyo Co Ltd | Novel isoquinoline derivative |
JPS57203068A (en) * | 1981-06-08 | 1982-12-13 | Teikoku Hormone Mfg Co Ltd | Novel 1-phenylisoquinoline derivative |
FR2567520B1 (fr) * | 1984-07-11 | 1987-01-02 | Carpibem | Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres |
JPS6230780A (ja) * | 1985-04-17 | 1987-02-09 | Ss Pharmaceut Co Ltd | 1,7−ナフチリジン誘導体及びこれを含有する薬剤 |
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JP2001511813A (ja) * | 1997-02-18 | 2001-08-14 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | Crfレセプターアンタゴニストおよびそれらに関連する方法 |
-
1996
- 1996-10-28 GB GBGB9622386.2A patent/GB9622386D0/en active Pending
-
1997
- 1997-10-16 TW TW086115176A patent/TW399052B/zh not_active IP Right Cessation
- 1997-10-24 IL IL12950297A patent/IL129502A0/xx not_active IP Right Cessation
- 1997-10-24 BR BRPI9713280-2A patent/BR9713280B1/pt not_active IP Right Cessation
- 1997-10-24 CN CN97199186A patent/CN1103773C/zh not_active Expired - Fee Related
- 1997-10-24 AU AU69084/98A patent/AU724471B2/en not_active Ceased
- 1997-10-24 JP JP52002898A patent/JP4451496B2/ja not_active Expired - Fee Related
- 1997-10-24 KR KR10-1999-7003661A patent/KR100524329B1/ko not_active IP Right Cessation
- 1997-10-24 AT AT97948803T patent/ATE236155T1/de not_active IP Right Cessation
- 1997-10-24 CA CA002269946A patent/CA2269946C/en not_active Expired - Fee Related
- 1997-10-24 DK DK97948803T patent/DK0934320T3/da active
- 1997-10-24 SK SK557-99A patent/SK283562B6/sk unknown
- 1997-10-24 ES ES97948803T patent/ES2196377T3/es not_active Expired - Lifetime
- 1997-10-24 EP EP97948803A patent/EP0934320B1/en not_active Expired - Lifetime
- 1997-10-24 TR TR1999/00920T patent/TR199900920T2/tr unknown
- 1997-10-24 NZ NZ335363A patent/NZ335363A/xx unknown
- 1997-10-24 PE PE1997000953A patent/PE10899A1/es not_active Application Discontinuation
- 1997-10-24 US US09/297,245 patent/US6136821A/en not_active Expired - Fee Related
- 1997-10-24 SI SI9730541T patent/SI0934320T1/xx unknown
- 1997-10-24 CZ CZ991466A patent/CZ146699A3/cs unknown
- 1997-10-24 PT PT97948803T patent/PT934320E/pt unknown
- 1997-10-24 PL PL97332738A patent/PL189280B1/pl not_active IP Right Cessation
- 1997-10-24 HU HU9904204A patent/HUP9904204A3/hu unknown
- 1997-10-24 WO PCT/EP1997/005898 patent/WO1998018796A1/en not_active Application Discontinuation
- 1997-10-24 DE DE69720493T patent/DE69720493T2/de not_active Expired - Lifetime
- 1997-10-24 AR ARP970104916A patent/AR009128A1/es unknown
- 1997-10-27 ID IDP973530A patent/ID18623A/id unknown
- 1997-10-27 MY MYPI97005054A patent/MY132642A/en unknown
- 1997-10-27 ZA ZA9709593A patent/ZA979593B/xx unknown
- 1997-10-28 CO CO97063263A patent/CO4910164A1/es unknown
-
1999
- 1999-04-19 IL IL129502A patent/IL129502A/en unknown
- 1999-04-21 NO NO19991903A patent/NO312677B1/no unknown
-
2000
- 2000-02-11 HK HK00100828A patent/HK1022305A1/xx not_active IP Right Cessation
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