TR199801443T2 - Insana ait HIV gerilmelerinin fenotipik ilaç duyarliligi temel alinarak HIV-pozitif olan hastalarin kemoterapisini idare metodu. - Google Patents

Insana ait HIV gerilmelerinin fenotipik ilaç duyarliligi temel alinarak HIV-pozitif olan hastalarin kemoterapisini idare metodu.

Info

Publication number
TR199801443T2
TR199801443T2 TR1998/01443T TR9801443T TR199801443T2 TR 199801443 T2 TR199801443 T2 TR 199801443T2 TR 1998/01443 T TR1998/01443 T TR 1998/01443T TR 9801443 T TR9801443 T TR 9801443T TR 199801443 T2 TR199801443 T2 TR 199801443T2
Authority
TR
Turkey
Prior art keywords
hiv
symmetric
wild
sequence
value
Prior art date
Application number
TR1998/01443T
Other languages
English (en)
Inventor
De B�Thune Marie-Pierre
Hertogs Kurt
Pauwels Rudi
Original Assignee
Virco N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virco N.V. filed Critical Virco N.V.
Publication of TR199801443T2 publication Critical patent/TR199801443T2/tr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Tercihen RT ve protazi kodlayan, bir hastadan elde edilen HIV pol geninden bir diziye sahip olan HIV enfeksiyonuna duyarli olan bir hücre hattini transfekte etmeyi ve dizinin yok edildigi bir HIV-DNA yapilanmasini; bir simerik virüs stogu yaratacak sekilde transfekte edilen hücreleri kültürlemeyi; simerik virüslerin HIV pol geniyle sifrelenen enzimin inhibitörüne fenotipik duyarliligini degerlendirmeyi ve oraya bir deger atamayi; simerik virüs duyarliligi için degeri ve HIV'nin yabani tipte bir simerik gerilmesi için karsilik gelen degeri içeren bir veri seti yapilandirmayi; en azindan ilave iki inhibitör için duyarlilik degerlendirmesini tekrarlamayi ve bu vasitayla toplam olarak en azindan böyle üç adet veri setini yapilandirmayi, simerik ile yabani tipteki duyarliliklar arasindaki fark her bir veri setinin olmasi durumunda bahis konusu inhibitörle tedaviye simerik stogun direncinin görsel bir ölçümünü saglayacak sekilde iki boyutlu veya üç boyutlu grafikteki veri (DEVAMI VAR)
TR1998/01443T 1996-01-26 1997-01-24 Insana ait HIV gerilmelerinin fenotipik ilaç duyarliligi temel alinarak HIV-pozitif olan hastalarin kemoterapisini idare metodu. TR199801443T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96200175 1996-01-26

Publications (1)

Publication Number Publication Date
TR199801443T2 true TR199801443T2 (tr) 1998-10-21

Family

ID=8223611

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01443T TR199801443T2 (tr) 1996-01-26 1997-01-24 Insana ait HIV gerilmelerinin fenotipik ilaç duyarliligi temel alinarak HIV-pozitif olan hastalarin kemoterapisini idare metodu.

Country Status (21)

Country Link
US (3) US6221578B1 (tr)
EP (1) EP0877937B1 (tr)
KR (1) KR100495690B1 (tr)
CN (2) CN1209875A (tr)
AT (1) ATE217971T1 (tr)
AU (1) AU717755B2 (tr)
BG (1) BG102710A (tr)
BR (1) BR9707204A (tr)
CZ (1) CZ292899B6 (tr)
DE (1) DE69712731T2 (tr)
ES (1) ES2177922T3 (tr)
HU (1) HU226203B1 (tr)
IL (1) IL125442A (tr)
IS (1) IS4799A (tr)
NO (1) NO321329B1 (tr)
NZ (1) NZ325912A (tr)
PL (1) PL186473B1 (tr)
SK (1) SK283878B6 (tr)
TR (1) TR199801443T2 (tr)
WO (1) WO1997027480A1 (tr)
ZA (1) ZA97669B (tr)

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Also Published As

Publication number Publication date
BG102710A (en) 1999-03-31
HU226203B1 (en) 2008-06-30
ATE217971T1 (de) 2002-06-15
SK100298A3 (en) 1999-02-11
EP0877937B1 (en) 2002-05-22
DE69712731D1 (de) 2002-06-27
IL125442A0 (en) 1999-03-12
EP0877937A1 (en) 1998-11-18
US6528251B2 (en) 2003-03-04
KR100495690B1 (ko) 2005-11-08
NO983300D0 (no) 1998-07-16
NO321329B1 (no) 2006-04-24
US20020042679A1 (en) 2002-04-11
IL125442A (en) 2002-03-10
HUP9902618A3 (en) 2001-04-28
US6221578B1 (en) 2001-04-24
BR9707204A (pt) 1999-12-28
US20030152917A1 (en) 2003-08-14
CZ292899B6 (cs) 2003-12-17
NZ325912A (en) 1999-01-28
SK283878B6 (sk) 2004-04-06
NO983300L (no) 1998-09-25
CN1991365A (zh) 2007-07-04
PL328069A1 (en) 1999-01-04
DE69712731T2 (de) 2003-02-06
HUP9902618A2 (hu) 1999-12-28
IS4799A (is) 1998-07-20
WO1997027480A1 (en) 1997-07-31
CZ233598A3 (cs) 1999-06-16
AU1316897A (en) 1997-08-20
AU717755B2 (en) 2000-03-30
ZA97669B (en) 1998-06-25
ES2177922T3 (es) 2002-12-16
KR19990082027A (ko) 1999-11-15
CN1209875A (zh) 1999-03-03
PL186473B1 (pl) 2004-01-30

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