DE60327768D1 - Mutationsprofile bei mit phänotypischer medikamentenresistenz korrelierter hiv-1-protease - Google Patents
Mutationsprofile bei mit phänotypischer medikamentenresistenz korrelierter hiv-1-proteaseInfo
- Publication number
- DE60327768D1 DE60327768D1 DE60327768T DE60327768T DE60327768D1 DE 60327768 D1 DE60327768 D1 DE 60327768D1 DE 60327768 T DE60327768 T DE 60327768T DE 60327768 T DE60327768 T DE 60327768T DE 60327768 D1 DE60327768 D1 DE 60327768D1
- Authority
- DE
- Germany
- Prior art keywords
- drug
- hiv
- phenotypic
- mutational profiles
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/50—Mutagenesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39275302P | 2002-07-01 | 2002-07-01 | |
PCT/EP2003/050277 WO2004003817A1 (en) | 2002-07-01 | 2003-06-30 | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60327768D1 true DE60327768D1 (de) | 2009-07-09 |
Family
ID=30000930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60327768T Expired - Lifetime DE60327768D1 (de) | 2002-07-01 | 2003-06-30 | Mutationsprofile bei mit phänotypischer medikamentenresistenz korrelierter hiv-1-protease |
Country Status (7)
Country | Link |
---|---|
US (2) | US7217506B2 (de) |
EP (1) | EP1520247B1 (de) |
AT (1) | ATE432506T1 (de) |
AU (1) | AU2003254500B2 (de) |
CA (1) | CA2490862A1 (de) |
DE (1) | DE60327768D1 (de) |
WO (1) | WO2004003817A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0011555A (pt) * | 1999-05-28 | 2002-02-26 | Virco Nv | Perfis mutacionais em transcriptase reversa de hiv-1 correlacionada com resistência fenotìpica à droga |
WO2002033638A2 (en) * | 2000-10-20 | 2002-04-25 | Virco Bvba | Mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
WO2004003817A1 (en) | 2002-07-01 | 2004-01-08 | Tibotec Pharmaceuticals Ltd. | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
US7473524B2 (en) * | 2002-07-01 | 2009-01-06 | Hilde Azijn | Mutational profiles in HIV-1 protease correlated with phenotypic drug resistance |
US20050214744A1 (en) * | 2002-07-01 | 2005-09-29 | Hilde Azjin | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
US7372540B2 (en) * | 2004-10-12 | 2008-05-13 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method |
WO2006089942A1 (en) | 2005-02-25 | 2006-08-31 | Tibotec Pharmaceuticals Ltd. | Protease inhibitor precursor synthesis |
EP2458018A3 (de) * | 2005-05-27 | 2012-07-25 | Monogram BioSciences, Inc. | Verfahren und Zusammensetzungen zum Bestimmen der HIV-1-Beständigkeit gegenüber Proteasehemmern |
CA2637203A1 (en) * | 2006-01-19 | 2007-07-26 | Monogram Biosciences, Inc. | Method for determining resistance of hiv to protease inhibitor treatment |
EP1987458A1 (de) * | 2006-02-03 | 2008-11-05 | Virco BVBA | Quantitatives hiv-phänotyp- oder tropismus-assay |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US327742A (en) | 1885-10-06 | Machine for making nuts | ||
GB2229340B (en) | 1989-03-17 | 1994-02-09 | Technophone Ltd | Radio telephone system |
GB8918226D0 (en) | 1989-08-09 | 1989-09-20 | Wellcome Found | Dna assays |
EP0428000A1 (de) | 1989-11-03 | 1991-05-22 | Abbott Laboratories | Fluorogene Substrate zum Nachweis von proteolytischer Enzymaktivität |
US5235039A (en) | 1991-06-10 | 1993-08-10 | Eli Lilly And Company | Substrates for hiv protease |
WO1993023574A1 (en) | 1992-05-14 | 1993-11-25 | Kozal Michael J | Polymerase chain reaction assays for monitoring antiviral therapy |
US6063562A (en) | 1994-09-16 | 2000-05-16 | Sepracor, Inc. | In vitro method for predicting the evolutionary response of HIV protease to a drug targeted thereagainst |
US5685141A (en) | 1995-12-26 | 1997-11-11 | General Electric Company | Lock for nozzle control in the event of hydraulic failure |
ATE217971T1 (de) | 1996-01-26 | 2002-06-15 | Virco Nv | Verfahren zur überwachung der chemotherapie von hiv-positiven patienten basierend auf der phenotypischen medikamentempfindlichkeit vom hiv stamm des patienten |
JPH11502727A (ja) | 1996-01-26 | 1999-03-09 | イノジェネティックス・ナムローゼ・フェンノートシャップ | 逆転写酵素遺伝子における薬剤により誘発された変異の検出方法 |
AP9801360A0 (en) | 1996-01-29 | 1998-12-31 | Virologic Incorporated | Compositions and methods ofr determining anti-viral drug susceptibility and resistance and anti-viral drug screening. |
JP3062459B2 (ja) | 1996-08-14 | 2000-07-10 | 理化学研究所 | ポリエステル重合酵素遺伝子及びポリエステルの製造方法 |
MXPA00011623A (es) | 1998-05-26 | 2002-10-17 | Virologic Inc | Medios y metodos para verificar la terapia antirretroviral con inhibidor no nucleosidico de la transcriptasa inversa. |
WO1999061666A1 (en) | 1998-05-28 | 1999-12-02 | Visible Genetics Inc. | Use of polymorphisms as a predictor of drug-resistance mutations |
PT2336134T (pt) | 1998-06-23 | 2016-10-19 | The Board Of Trustees Of The Univ Of Illionis | Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia |
MXPA00012843A (es) | 1998-06-24 | 2002-04-24 | Virologic Inc | Medios y metodo para verificar la terapia antirretroviral con un inhibidor nucleosico de la transcriptasa inversa y guia de decisiones terapeuticas en el tratamiento del vih/sida. |
AU762811B2 (en) * | 1998-06-24 | 2003-07-03 | Innogenetics N.V. | Method for detection of drug-selected mutations in the HIV protease gene |
BR0011555A (pt) | 1999-05-28 | 2002-02-26 | Virco Nv | Perfis mutacionais em transcriptase reversa de hiv-1 correlacionada com resistência fenotìpica à droga |
WO2000078996A1 (en) | 1999-06-22 | 2000-12-28 | Virologic, Inc. | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of hiv/aids |
WO2000078994A1 (en) | 1999-06-23 | 2000-12-28 | The Penn State Research Foundation | Compositions and methods for the quantification of sterol biosynthetic flux |
WO2001079540A2 (en) * | 2000-04-18 | 2001-10-25 | Virco Bvba | Methods for measuring drug resistance |
CA2406830C (en) | 2000-04-20 | 2012-10-02 | Virco Bvba | Method for mutation detection in hiv using pol sequencing |
CA2415832C (en) | 2000-06-08 | 2012-07-24 | Brendan Larder | Method and system for predicting therapeutic agent resistance and for defining the genetic basis of drug resistance using neural networks |
US7058616B1 (en) | 2000-06-08 | 2006-06-06 | Virco Bvba | Method and system for predicting resistance of a disease to a therapeutic agent using a neural network |
CA2422815A1 (en) | 2000-09-15 | 2002-03-21 | Virologic, Inc. | Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of hiv/aids |
AU1234402A (en) | 2000-10-20 | 2002-04-29 | Virco Nv | Establishment of biological cut-off values for predicting resistance to therapy |
WO2002033638A2 (en) | 2000-10-20 | 2002-04-25 | Virco Bvba | Mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
JP2002199890A (ja) | 2000-10-23 | 2002-07-16 | Inst Of Physical & Chemical Res | 生分解性ポリエステル合成酵素の改変方法 |
EP1364071A2 (de) | 2000-11-10 | 2003-11-26 | Bioalliance Pharma (S.A.) | Neue methode zur analyse von phänotypischen eigenschaften des humanen immunschwächevirus (hiv) |
ES2275866T3 (es) | 2001-02-14 | 2007-06-16 | Tibotec Pharmaceuticals Ltd. | 2-(aminosustituido)-benzotiazol-sulfonamidas de amplio esprecto inhibidoras de la proteasa de vih. |
US7473524B2 (en) | 2002-07-01 | 2009-01-06 | Hilde Azijn | Mutational profiles in HIV-1 protease correlated with phenotypic drug resistance |
US20050214744A1 (en) | 2002-07-01 | 2005-09-29 | Hilde Azjin | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
WO2004003817A1 (en) | 2002-07-01 | 2004-01-08 | Tibotec Pharmaceuticals Ltd. | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
US7294642B2 (en) | 2002-09-06 | 2007-11-13 | Elan Pharmaceuticals, Inc. | 1,3-Diamino-2-hydroxypropane pro-drug derivatives |
EP1605064A1 (de) | 2004-06-07 | 2005-12-14 | UMC Utrecht Holding B.V. | HIV Varianten, welche einen neuen Resistenzmechanismus gegenüber Proteaseinhibitoren zeigen, diagnostische Assays zum Nachweis der Varianten, und Methoden zur Identifikation von Medikamenten, welche gegen die resistenten Varianten wirksam sind. |
-
2003
- 2003-06-30 WO PCT/EP2003/050277 patent/WO2004003817A1/en not_active Application Discontinuation
- 2003-06-30 US US10/519,035 patent/US7217506B2/en not_active Expired - Fee Related
- 2003-06-30 EP EP03761598A patent/EP1520247B1/de not_active Expired - Lifetime
- 2003-06-30 AU AU2003254500A patent/AU2003254500B2/en not_active Ceased
- 2003-06-30 DE DE60327768T patent/DE60327768D1/de not_active Expired - Lifetime
- 2003-06-30 AT AT03761598T patent/ATE432506T1/de not_active IP Right Cessation
- 2003-06-30 CA CA002490862A patent/CA2490862A1/en not_active Abandoned
-
2006
- 2006-12-20 US US11/613,584 patent/US8592161B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7217506B2 (en) | 2007-05-15 |
ATE432506T1 (de) | 2009-06-15 |
AU2003254500B2 (en) | 2009-11-19 |
US8592161B2 (en) | 2013-11-26 |
EP1520247B1 (de) | 2009-05-27 |
CA2490862A1 (en) | 2004-01-08 |
WO2004003817A1 (en) | 2004-01-08 |
EP1520247A1 (de) | 2005-04-06 |
AU2003254500A1 (en) | 2004-01-19 |
US20070269816A1 (en) | 2007-11-22 |
US20050233312A1 (en) | 2005-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |