TR199801408T2 - Toz halinde pulmoner sürfaktan preparatlarin üretimi için yöntem. - Google Patents

Toz halinde pulmoner sürfaktan preparatlarin üretimi için yöntem.

Info

Publication number
TR199801408T2
TR199801408T2 TR1998/01408T TR9801408T TR199801408T2 TR 199801408 T2 TR199801408 T2 TR 199801408T2 TR 1998/01408 T TR1998/01408 T TR 1998/01408T TR 9801408 T TR9801408 T TR 9801408T TR 199801408 T2 TR199801408 T2 TR 199801408T2
Authority
TR
Turkey
Prior art keywords
pulmonary surfactant
manufacture
powder form
surfactant preparations
hydrophobic protein
Prior art date
Application number
TR1998/01408T
Other languages
English (en)
Inventor
Eistetter Klaus
Original Assignee
Byk, Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19602332A external-priority patent/DE19602332A1/de
Application filed by Byk, Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk, Gulden Lomberg Chemische Fabrik Gmbh
Publication of TR199801408T2 publication Critical patent/TR199801408T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Burada, hidrofod pulmoner sürfaktan proteinleri içeren toz biçiminde bir pulmoner sürfaktan preparatin üretim yöntemi açiklanmaktadir. Bu yöntemin özelligi, hidrofob pulmoner sürfaktan proteinler içeren organik bir solüsyon veya süspansiyon ve istenirse baska ögelerin, püskürterek kurutmaya tabi tutulmasidir. Böylece depo edilebilir, inhalativ olarak da verilebilen kolayca hazirlanabilir toz seklinde preparatlar elde edilmektedir.
TR1998/01408T 1996-01-24 1997-01-18 Toz halinde pulmoner sürfaktan preparatlarin üretimi için yöntem. TR199801408T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602332A DE19602332A1 (de) 1996-01-24 1996-01-24 Verfahren zur Herstellung von pulverförmigen Lungensurfactant-Zubereitungen
EP96103442 1996-03-06

Publications (1)

Publication Number Publication Date
TR199801408T2 true TR199801408T2 (tr) 1998-10-21

Family

ID=26022286

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01408T TR199801408T2 (tr) 1996-01-24 1997-01-18 Toz halinde pulmoner sürfaktan preparatlarin üretimi için yöntem.

Country Status (15)

Country Link
US (1) US6315983B1 (tr)
EP (1) EP0877602B1 (tr)
JP (1) JP3725166B2 (tr)
KR (1) KR100449789B1 (tr)
AT (1) ATE212220T1 (tr)
CA (1) CA2244767C (tr)
CY (1) CY2366B1 (tr)
CZ (1) CZ292186B6 (tr)
DE (1) DE59706180D1 (tr)
DK (1) DK0877602T3 (tr)
ES (1) ES2171883T3 (tr)
PT (1) PT877602E (tr)
TR (1) TR199801408T2 (tr)
UA (1) UA59358C2 (tr)
WO (1) WO1997026863A1 (tr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
AU5719798A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems, Inc. Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
EP1767195A3 (en) * 1998-08-25 2007-04-04 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
AU758351B2 (en) * 1998-08-25 2003-03-20 Alkermes, Inc. Stable spray-dried protein formulations
AU1161300A (en) * 1998-11-10 2000-05-29 Byk Gulden Lomberg Chemische Fabrik Gmbh Treatment set containing lungsurfactant compositions
CA2372558A1 (en) * 1999-06-11 2000-12-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
EP1210069B1 (en) * 1999-08-25 2004-12-29 Advanced Inhalation Research, Inc. Large porous particles obtainable by spray-drying and suitable for pulmonary administration
US6749835B1 (en) * 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
EP1216052A1 (en) 1999-09-16 2002-06-26 Byk Gulden Lomberg Chemische Fabrik GmbH Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
MXPA02001323A (es) 2000-05-10 2004-07-16 Alliance Pharma Microgranulos con base fosfolipida para la liberacion de farmaco.
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) * 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
AU2002338882B2 (en) 2001-10-11 2008-04-03 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Novel use of pulmonary surfactant
AU2002346472A1 (en) * 2001-11-20 2003-06-10 Advanced Inhalation Research, Inc. Particulate compositions for improving solubility of poorly soluble agents
ATE508735T1 (de) 2001-12-19 2011-05-15 Novartis Ag Pulmonale verabreichung von aminoglykosiden
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
KR20040093155A (ko) * 2002-03-18 2004-11-04 야마노우치세이야쿠 가부시키가이샤 흡입용 분말 의약조성물 및 이의 제조방법
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
WO2005115520A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
WO2006013183A1 (en) 2004-08-06 2006-02-09 Altana Pharma Ag Composition comprising a pulmonary surfactant and a tnf-derived peptide
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
KR100770362B1 (ko) * 2004-12-30 2007-10-26 (주)두비엘 분무건조 고분자형 콜렉틴족 단백질 및 그의 제조방법
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
EP2009023A1 (en) * 2007-06-04 2008-12-31 Rentschler Beteiligungs GmbH Novel peptides and their use for the treatment of edema
ES2565219T3 (es) 2008-03-17 2016-04-01 Discovery Laboratories, Inc. Adaptador de circuito de ventilación y sistema proximal de administración de aerosol
CA2905402C (en) 2008-10-22 2017-02-28 Trudell Medical International Modular aerosol delivery system
US9289388B2 (en) 2008-12-10 2016-03-22 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
BRPI1011721B1 (pt) * 2009-03-26 2021-11-16 Pulmatrix, Inc Formulações em pó seco inaláveis compreendendo sal de cátion de metal divalente e métodos para tratar doenças pulmonares
DK2308489T3 (da) 2009-10-05 2014-03-24 Nutri Fit Gmbh & Co Kg Sammensætninger til anvendelse ved behandling eller forebyggelse af lungeskade, der fremkaldes af en stofskiftebelastning samt fremgangsmåder til forøgelse af pattedyrs fysiske kapacitet
EP2608769B1 (en) 2010-08-23 2019-11-06 Fraunhofer Gesellschaft zur Förderung der Angewand Humidified particles comprising a therapeutically active substance
HUE026363T2 (en) 2012-03-28 2016-06-28 Discovery Lab Inc Lyophilization of pulmonary synthetic liposomal surfactant
US10737088B2 (en) 2014-03-05 2020-08-11 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Device for providing a constant amount of aerosol
AU2015226287B2 (en) 2014-03-05 2019-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidifier for humidifying an aerosol
CA2940351A1 (en) * 2014-03-18 2015-09-24 Apeptico Forschung Und Entwicklung Gmbh Dry-powder peptide medicament
JP7240178B2 (ja) * 2016-06-24 2023-03-15 シヴィタス セラピューティクス、インコーポレイテッド 吸入用サーファクタント製剤
AU2018392461A1 (en) 2017-12-21 2020-07-02 Civitas Therapeutics, Inc. Surfactant formulations for inhalation
JP7419253B2 (ja) * 2017-12-21 2024-01-22 キウィタス セラピューティクス，インコーポレイテッド 吸入のための界面活性剤製剤

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183621A (ja) * 1982-04-22 1983-10-26 Teijin Ltd 肺表面活性物質を有効成分とする粉末剤の調製法
DE3229179C2 (de) 1982-08-05 1986-04-17 A. Nattermann & Cie GmbH, 5000 Köln Lungensurfactant
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US5164369A (en) 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
DK0482097T3 (da) 1989-07-11 2001-09-17 Genentech Inc Tensidpræparater og fremgangsmåder
IN172208B (tr) * 1990-04-02 1993-05-01 Sint Sa
CA2093133C (en) 1990-10-17 1999-03-30 Andrew S. Janoff Synthetic lung surfactant
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0655237A1 (de) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Medizinische Aerosolformulierung
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
AU706195B2 (en) * 1995-04-14 1999-06-10 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
US5780014A (en) 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
AU5719798A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems, Inc. Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
AU758351B2 (en) 1998-08-25 2003-03-20 Alkermes, Inc. Stable spray-dried protein formulations

Also Published As

Publication number Publication date
ATE212220T1 (de) 2002-02-15
EP0877602A1 (de) 1998-11-18
DE59706180D1 (de) 2002-03-14
US6315983B1 (en) 2001-11-13
CZ233898A3 (cs) 1999-02-17
WO1997026863A1 (de) 1997-07-31
CZ292186B6 (cs) 2003-08-13
ES2171883T3 (es) 2002-09-16
EP0877602B1 (de) 2002-01-23
UA59358C2 (uk) 2003-09-15
JP3725166B2 (ja) 2005-12-07
PT877602E (pt) 2002-07-31
KR100449789B1 (ko) 2005-02-03
CA2244767A1 (en) 1997-07-31
JP2000503976A (ja) 2000-04-04
CY2366B1 (en) 2004-06-04
DK0877602T3 (da) 2002-05-06
CA2244767C (en) 2005-11-22
KR19990081886A (ko) 1999-11-15

Similar Documents

Publication Publication Date Title
TR199801408T2 (tr) Toz halinde pulmoner sürfaktan preparatlarin üretimi için yöntem.
CY1107488T1 (el) Σταθερα ξηραμενα δια ψεκασμου πρωτεϊνικα σκευασματα
ATE268817T1 (de) Salz-stabilisierte enzymzubereitung
CA2027592A1 (en) Solid pharmaceutical preparations of active form of vitamin d_ of improved stability
SE8702907D0 (sv) Stable pharmaceutical preparation containing granulocyte colony stimulating factor and process for producing the same
ES477351A1 (es) Procedimiento de conservacion de composicion a base de dis- persiones acuosas de esferillas llamadas liposomas.
ATE230612T1 (de) Stabile pulverförmige vitamin- und carotinoid- zubereitungen und vefahren zu deren herstellung
ATE319329T1 (de) Stabile pulverförmige vitamin-und/oder carotinoid-präparate und verfahren zu deren herstellung
AR240872A1 (es) Novedosas composiciones tensioactivas con base de esteres fosforicos de derivados polioxialquenados, su procedimiento de preparacion y su aplicacion a la formulacion de materias activas.
FI940696A0 (fi) Uudet pyratsiinijohdannaiset, niiden valmistus ja käyttö
SE8603272L (sv) Forfarande for konservering av vexter
SG64693G (en) Nicorandil-containing preparation for injection
EP0402637A3 (en) Stable freeze dried polyhematoporphyrin ether/ester composition
SE8601457D0 (sv) Compositions of liposomes and b?712-receptor active substances for inhalation
EA199800649A1 (ru) Способ получения порошковых препаратов лёгочного поверхностно-активного вещества
DE60001096D1 (de) Lipidmembran zusammensetzungen
MY101266A (en) Pharmaceutical formulations
JPS5659707A (en) Lasting antibiotic pharmaceutical and its preparation
ES2033512T3 (es) Composicion antiastenica, su procedimiento de preparacion y su utilizacion.
JPS5492633A (en) Creamy or milky lotion cosmetics
JPS5696693A (en) Production of human standard enzyme sample from human placenta
KR870010793A (ko) 수혈과 인삼엑기스를 이용한 삼혈분말의 제조방법
SE9004076D0 (sv) Anvaendning av 10-acetyl-1,8,9-triacetoxi-antracen som antiinflammatoriskst medel vid framstaellning av farmaceutiska och kosmetiska kompositioner
ATE283341T1 (de) Teppichreinigungspulver mit einer aktivsauerstoffquelle
MX9700484A (es) Leche sin lactosa y leche en polvo sin lactosa, y alimentos que los contienen y proceso para fabricarlos.