SV2006002212A - Produccion de a-betaq ref.2004658-0076 - Google Patents
Produccion de a-betaq ref.2004658-0076Info
- Publication number
- SV2006002212A SV2006002212A SV2005002212A SV2005002212A SV2006002212A SV 2006002212 A SV2006002212 A SV 2006002212A SV 2005002212 A SV2005002212 A SV 2005002212A SV 2005002212 A SV2005002212 A SV 2005002212A SV 2006002212 A SV2006002212 A SV 2006002212A
- Authority
- SV
- El Salvador
- Prior art keywords
- cumulative
- culture
- accumulative
- glutamine
- amino acid
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000001186 cumulative effect Effects 0.000 abstract 6
- 235000001014 amino acid Nutrition 0.000 abstract 3
- 229940024606 amino acid Drugs 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 2
- 229960001230 asparagine Drugs 0.000 abstract 2
- 235000009582 asparagine Nutrition 0.000 abstract 2
- 238000009825 accumulation Methods 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 238000012136 culture method Methods 0.000 abstract 1
- 229910001410 inorganic ion Inorganic materials 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Botany (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN SISTEMA MEJORADO PARA LA PRODUCCIÓN A GRAN ESCALA DE PROTEÍNAS Y/O A-BETA EN CULTIVO CELULAR, PARTICULARMENTE EN MEDIOS CARACTERIZADOS POR UNO O MÁS DE : I) UNA CONCENTRACIÓN ACUMULATIVA DE AMINOÁCIDO MAYOR DE UNOS 70 MM; II) UNA GLUTAMINA MOLAR ACUMULATIVA A UNA PROPORCIÓN DE ASPARAGINA ACUMULATIVA MENOR DE UNOS 2; III) UNA GLUTAMINA MOLARA ACUMULATIVA A PROPORCIÓN TOTAL ACUMULATIVA DEL AMINOÁCIDO MENOR DE UNOS 0.2; IV) UN ION INORGÁNICO MOLAR ACUMULATIVO A LA PROPRCIÓN TOTAL ACUMULATIVA DE AMINOÁCIDO ENTRE UNOS 0.4 A 1; Ó SE PROPORICONA V) UNA CONCENTRACIÓN COMBINADA CUMULATIVA DE GLUTAMINA Y ACUMULATIVA DE ASPARAGINA ENTRE UNOS 16 Y36 MM. EL USO DE DICHO SISTEMA PERMITE LOS ALTOS NIVELES DE LA PRODUCCIÓN DE A-BETA Y AMINORA LA ACUMULACIÓN DE CIERTOS FACTORES INDESEABLES COMO AMONIO Y/O LACTATO. ADICIONALMENTE, SE PROPORCIONAN LOS MÉTODOS DE CULTIVO QUE INCLUYEN UN CAMBIO DE TEMPERATURA, TÍPICAMENTE INCLUYENDO UNA DISMINUCIÓN EN LA TEMPERATURA CUANDO EL CULTIVO HAYA ALCANZADO UN 20-80% DE SU MÁXIMA DENSIDAD CELULAR. ALTERNATIVA O ADICIONALMENTE, ESTE INVENTO BRINDA LOS MÉTODOS DE MOSO QUE, DESPUÉS DE ALCANZAR UN MÁXIMO, LOS NIVELES DE LACTATO Y/O AMONIO EN EL CULTIVO DISMINUYAN EN TIEMPO EXTRA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60493604P | 2004-08-27 | 2004-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2006002212A true SV2006002212A (es) | 2006-06-26 |
Family
ID=35500647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2005002212A SV2006002212A (es) | 2004-08-27 | 2005-08-26 | Produccion de a-betaq ref.2004658-0076 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7335491B2 (es) |
| EP (2) | EP2348126A3 (es) |
| JP (3) | JP2008511328A (es) |
| KR (1) | KR100998857B1 (es) |
| CN (1) | CN101048512B (es) |
| AR (1) | AR050471A1 (es) |
| AU (1) | AU2005280090A1 (es) |
| BR (1) | BRPI0514680A (es) |
| CA (1) | CA2578137C (es) |
| CR (1) | CR8996A (es) |
| EC (1) | ECSP077351A (es) |
| EG (1) | EG25848A (es) |
| ES (1) | ES2599103T3 (es) |
| HN (1) | HN2005000486A (es) |
| IL (1) | IL181587A (es) |
| MX (1) | MX2007002382A (es) |
| MY (1) | MY146097A (es) |
| NO (1) | NO20071571L (es) |
| NZ (1) | NZ591233A (es) |
| PE (2) | PE20100147A1 (es) |
| RU (1) | RU2418858C2 (es) |
| SG (1) | SG155250A1 (es) |
| SV (1) | SV2006002212A (es) |
| TW (1) | TWI374935B (es) |
| UA (1) | UA89644C2 (es) |
| WO (1) | WO2006026408A2 (es) |
| ZA (1) | ZA200702487B (es) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| TWI364458B (en) | 2004-08-27 | 2012-05-21 | Wyeth Res Ireland Ltd | Production of tnfr-lg |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| TWI374935B (en) | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
| AR058140A1 (es) * | 2005-10-24 | 2008-01-23 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
| US20070231895A1 (en) * | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
| DK1976877T4 (en) | 2005-11-30 | 2017-01-16 | Abbvie Inc | Monoclonal antibodies to amyloid beta protein and uses thereof |
| PL1954718T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał |
| CA2632822C (en) | 2005-12-12 | 2018-08-28 | Ruth Greferath | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| ES2668212T3 (es) | 2006-07-13 | 2018-05-17 | Wyeth Llc | Producción de factor de coagulación IX con patrón de glucosilación mejorado |
| AR062065A1 (es) | 2006-07-14 | 2008-10-15 | Ac Immune Sa | Anticuerpo humanizado |
| CA2666317C (en) * | 2006-11-03 | 2013-08-06 | Wyeth | Glycolysis-inhibiting substances in cell culture |
| CA2668771C (en) | 2006-11-08 | 2016-03-15 | Wyeth | Rationally designed media for cell culture |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US20100311767A1 (en) * | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| EP2481408A3 (en) | 2007-03-01 | 2013-01-09 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
| RU2009132986A (ru) * | 2007-03-02 | 2011-04-10 | Уайт (Us) | Применение меди и глутамата в культуре клеток для производства полипептидов |
| EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| DK2154244T3 (en) | 2007-04-26 | 2017-06-12 | Chugai Pharmaceutical Co Ltd | CELL CULTIVATION PROCEDURE WHEN AN ACID-ENRICHED MEDIUM IS USED |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| PT2170389E (pt) * | 2007-06-12 | 2015-02-10 | Genentech Inc | Anticorpos humanizados contra amilóide beta |
| US9403902B2 (en) * | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
| AU2009236187B2 (en) * | 2008-04-17 | 2012-08-02 | Wyeth Llc | Methods for enhanced production of bone morphogenetic proteins |
| CA2734922C (en) | 2008-09-15 | 2020-01-14 | Laetitia Malphettes | Compositions comprising polynucleotides comprising hybrid osmo-responsive transcriptional regulatory elements and methods for producing a protein under conditions of hyperosmolarity |
| LT2464725T (lt) | 2009-08-11 | 2020-06-10 | F. Hoffmann-La Roche Ag | Baltymų gamyba ląstelių mitybinėje terpėje, kurioje nėra glutamino |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| US8470552B2 (en) * | 2009-10-12 | 2013-06-25 | Keck Graduate Institute | Strategy to reduce lactic acid production and control PH in animal cell culture |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| EP2545047B9 (en) | 2010-03-10 | 2015-06-10 | Probiodrug AG | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP2013523182A (ja) | 2010-04-15 | 2013-06-17 | アボット・ラボラトリーズ | アミロイドベータ結合タンパク質 |
| EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| CN102858953B (zh) * | 2010-04-26 | 2015-09-09 | 诺瓦提斯公司 | 改进的细胞培养基 |
| CN107254499B (zh) | 2010-04-26 | 2021-09-17 | 诺华股份有限公司 | 改进的细胞培养方法 |
| PL2563904T3 (pl) | 2010-04-26 | 2015-06-30 | Novartis Ag | Udoskonalona pożywka do hodowli komórkowej |
| CA2806909C (en) | 2010-07-30 | 2019-12-17 | Ac Immune S.A. | Safe and functional humanized antibodies |
| EP2603524A1 (en) | 2010-08-14 | 2013-06-19 | AbbVie Inc. | Amyloid-beta binding proteins |
| CA2807607A1 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Cell culture of growth factor-free adapted cells |
| JP6050264B2 (ja) | 2011-03-16 | 2016-12-21 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| LT2837680T (lt) * | 2011-07-01 | 2020-07-10 | Amgen Inc. | Žinduolių ląstelių kultūra |
| FI20115704L (fi) | 2011-07-01 | 2013-01-02 | Teknologian Tutkimuskeskus Vtt Oy | Vierasproteiinien tuoton parantaminen |
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| MX2016004564A (es) * | 2013-10-11 | 2016-07-12 | Regeneron Pharma | Cultivo celular metabolicamente optimizado. |
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| DE102017203908B3 (de) * | 2017-03-09 | 2018-05-30 | Evonik Technochemie Gmbh | Kulturmedium, umfassend Oligopeptide |
| EP3638772B1 (en) * | 2017-06-16 | 2024-08-28 | Katholieke Universiteit Leuven | Cell culture media for differentiation of stem cells into hepatocytes |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
| PT3818078T (pt) * | 2018-07-03 | 2024-04-18 | Bristol Myers Squibb Co | Métodos de produção de proteínas recombinantes |
| IL302538A (en) | 2019-12-06 | 2023-07-01 | Regeneron Pharma | Anti-VEGF protein preparations and methods for their production |
| EP4107249A1 (en) * | 2020-02-18 | 2022-12-28 | Boehringer Ingelheim International GmbH | Mammalian cell culture processes |
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| MXPA04008150A (es) | 2002-02-21 | 2005-06-17 | Wyeth Corp | Gasp1: una proteina que contiene dominio de folistatina. |
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-
2005
- 2005-08-25 TW TW094129074A patent/TWI374935B/zh not_active IP Right Cessation
- 2005-08-25 US US11/213,317 patent/US7335491B2/en not_active Expired - Fee Related
- 2005-08-26 EP EP10184494A patent/EP2348126A3/en not_active Withdrawn
- 2005-08-26 SV SV2005002212A patent/SV2006002212A/es unknown
- 2005-08-26 BR BRPI0514680-1A patent/BRPI0514680A/pt not_active Application Discontinuation
- 2005-08-26 SG SG200905720-9A patent/SG155250A1/en unknown
- 2005-08-26 NZ NZ591233A patent/NZ591233A/xx not_active IP Right Cessation
- 2005-08-26 KR KR1020077004809A patent/KR100998857B1/ko not_active IP Right Cessation
- 2005-08-26 WO PCT/US2005/030364 patent/WO2006026408A2/en active Application Filing
- 2005-08-26 PE PE2009001268A patent/PE20100147A1/es not_active Application Discontinuation
- 2005-08-26 JP JP2007530148A patent/JP2008511328A/ja active Pending
- 2005-08-26 AR ARP050103595A patent/AR050471A1/es not_active Application Discontinuation
- 2005-08-26 MY MYPI20054022A patent/MY146097A/en unknown
- 2005-08-26 RU RU2007108718/10A patent/RU2418858C2/ru not_active IP Right Cessation
- 2005-08-26 AU AU2005280090A patent/AU2005280090A1/en not_active Abandoned
- 2005-08-26 PE PE2005000986A patent/PE20060715A1/es not_active Application Discontinuation
- 2005-08-26 EP EP05791655.3A patent/EP1781803B1/en active Active
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2007
- 2007-02-27 IL IL181587A patent/IL181587A/en not_active IP Right Cessation
- 2007-02-27 EG EGNA2007000224 patent/EG25848A/xx active
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